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Translating myosin-binding protein C and titin abnormalities to whole-heart function using a novel calcium-contraction coupling model J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-03-08 Theo Arts, Aurore Lyon, Tammo Delhaas, Diederik W.D. Kuster, Jolanda van der Velden, Joost Lumens
Mutations in cardiac myosin-binding protein C (cMyBP-C) or titin may respectively lead to hypertrophic (HCM) or dilated (DCM) cardiomyopathies. The mechanisms leading to these phenotypes remain unclear because of the challenge of translating cellular abnormalities to whole-heart and system function.
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Cellular nucleic acid binding protein facilitates cardiac repair after myocardial infarction by activating β-catenin signaling J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-03-01 Chong Du, Shan Zhao, Tiankai Shan, Xudong Han, Qiqi Jiang, Jiawen Chen, Lingfeng Gu, Tianwen Wei, Tongtong Yang, Sibo Wang, Hao Wang, Xuejiang Guo, Liansheng Wang
The regenerative capacity of the adult mammalian heart is limited, while the neonatal heart is an organ with regenerative and proliferative ability. Activating adult cardiomyocytes (CMs) to re-enter the cell cycle is an effective therapeutic method for ischemic heart disease such as myocardial infarction (MI) and heart failure. Here, we aimed to reveal the role and potential mechanisms of cellular
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Modeling ionizing radiation-induced cardiovascular dysfunction with human iPSC-derived engineered heart tissues J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-02-29 Xu Cao, Dilip Thomas, Luke A. Whitcomb, Mingqiang Wang, Anushree Chatterjee, Adam J. Chicco, Michael M. Weil, Joseph C. Wu
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ATF6 protects against protein misfolding during cardiac hypertrophy J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-02-23 Christoph Hofmann, Marjan Aghajani, Cecily D. Alcock, Erik A. Blackwood, Clara Sandmann, Nicole Herzog, Julia Groß, Lars Plate, R. Luke Wiseman, Randal J. Kaufman, Hugo A. Katus, Tobias Jakobi, Mirko Völkers, Christopher C. Glembotski, Shirin Doroudgar
Cardiomyocytes activate the unfolded protein response (UPR) transcription factor ATF6 during pressure overload-induced hypertrophic growth. The UPR is thought to increase ER protein folding capacity and maintain proteostasis. ATF6 deficiency during pressure overload leads to heart failure, suggesting that ATF6 protects against myocardial dysfunction by preventing protein misfolding. However, conclusive
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Neutrophils are indispensable for adverse cardiac remodeling in heart failure J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-02-22 Sergey Antipenko, Nicolas Mayfield, Miki Jinno, Matthias Gunzer, Mohamed Ameen Ismahil, Tariq Hamid, Sumanth D. Prabhu, Gregg Rokosh
Persistent immune activation contributes significantly to left ventricular (LV) dysfunction and adverse remodeling in heart failure (HF). In contrast to their well-known essential role in acute myocardial infarction (MI) as first responders that clear dead cells and facilitate subsequent reparative macrophage polarization, the role of neutrophils in the pathobiology of chronic ischemic HF is poorly
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Gut microbial metabolite trimethylamine N-oxide induces aortic dissection J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-02-21 Shan Huang, Shijuan Gao, Yihui Shao, Ping Li, Jie Lu, Ke Xu, Zeyi Zhou, Yulin Li, Jie Du
Aortic dissection (AD) is the most catastrophic vascular disease with a high mortality rate. Trimethylamine N-oxide (TMAO), a gut microbial metabolite, has been implicated in the pathogenesis of cardiovascular diseases. However, the role of TMAO in AD and the underlying mechanisms remain unclear. This study aimed to explore the effects of TMAO on AD. Plasma and fecal samples from patients with AD and
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Novel roles of cardiac-derived erythropoietin in cardiac development and function J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-02-20 Melissa A. Allwood, Brittany A. Edgett, Mathew J. Platt, Jade P. Marrow, Bridget Coyle-Asbil, Emma J.B. Holjak, Victoria L. Nelson, Swara Bangali, Razan Alshamali, Kathy Jacyniak, Jorden M. Klein, Laura Farquharson, Nadya Romanova, Victoria Northrup, Leslie M. Ogilvie, Anmar Ayoub, Kjetil Ask, Matthew K. Vickaryous, Gregory M.T. Hare, Keith R. Brunt, Jeremy A. Simpson
The role of erythropoietin (EPO) has extended beyond hematopoiesis to include cytoprotection, inotropy, and neurogenesis. Extra-renal EPO has been reported for multiple tissue/cell types, but the physiological relevance remains unknown. Although the EPO receptor is expressed by multiple cardiac cell types and human recombinant EPO increases contractility and confers cytoprotection against injury, whether
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Cannabidiol protects against acute aortic dissection by inhibiting macrophage infiltration and PMAIP1-induced vascular smooth muscle cell apoptosis J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-02-20 Yilong Guo, Yang Che, Xuelin Zhang, Zongna Ren, Yinan Chen, Liliang Guo, Lin Mao, Ren Wei, Xiang Gao, Tao Zhang, Li Wang, Wei Guo
Acute aortic dissection (AAD) progresses rapidly and is associated with high mortality; therefore, there remains an urgent need for pharmacological agents that can protect against AAD. Herein, we examined the therapeutic effects of cannabidiol (CBD) in AAD by establishing a suitable mouse model. In addition, we performed human AAD single-cell RNA sequencing and mouse AAD bulk RNA sequencing to elucidate
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NCoR1 limits angiogenic capacity by altering Notch signaling J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-02-15 Tom Teichmann, Pedro Malacarne, Simonida Zehr, Stefan Günther, Beatrice Pflüger-Müller, Timothy Warwick, Ralf P. Brandes
Corepressors negatively regulate gene expression by chromatin compaction. Targeted regulation of gene expression could provide a means to control endothelial cell phenotype. We hypothesize that by targeting corepressor proteins, endothelial angiogenic function can be improved. To study this, the expression and function of nuclear corepressors in human umbilical vein endothelial cells (HUVEC) and in
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Exercise reduces pro-inflammatory lipids and preserves resolution mediators that calibrate macrophage-centric immune metabolism in spleen and heart following obesogenic diet in aging mice J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-02-15 Ganesh V. Halade, Gunjan Upadhyay, MathanKumar Marimuthu, Xuan Wanling, Vasundhara Kain
The study investigated the role of volunteer exercise and an obesogenic diet (OBD) in mice, focusing on the splenocardiac axis and inflammation-resolution signaling. Male C57BL/6J mice (2 months old) were assigned to control (CON) or OBD groups for ten months, then randomized into sedentary (Sed) or exercise (Exe) groups for two weeks. Leukocytes, heart function, structure, and spleen tissue examined
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Adipocyte-mediated electrophysiological remodeling of human stem cell - derived cardiomyocytes J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-02-10 Justin Morrissette-McAlmon, William R. Xu, Roald Teuben, Kenneth R. Boheler, Leslie Tung
Adipocytes normally accumulate in the epicardial and pericardial layers around the human heart, but their infiltration into the myocardium can be proarrhythmic. Human adipose derived stem/stromal cells and human induced pluripotent stem cells (hiPSC) were differentiated, respectively into predominantly white fat-like adipocytes (hAdip) and ventricular cardiomyocytes (CMs). Adipocytes cultured in CM
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Promoting cardiomyocyte proliferation for myocardial regeneration in large mammals J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-02-09 Thanh Nguyen, Manuel Rosa-Garrido, Hesham Sadek, Daniel J. Garry, Jianyi (Jay) Zhang
From molecular and cellular perspectives, heart failure is caused by the loss of cardiomyocytes—the fundamental contractile units of the heart. Because mammalian cardiomyocytes exit the cell cycle shortly after birth, the cardiomyocyte damage induced by myocardial infarction (MI) typically leads to dilatation of the left ventricle (LV) and often progresses to heart failure. However, recent findings
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Pluripotent stem cell-based cardiac regenerative therapy for heart failure J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-02-06 Yusuke Soma, Hidenori Tani, Yuika Morita-Umei, Yoshikazu Kishino, Keiichi Fukuda, Shugo Tohyama
Cardiac regenerative therapy using human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is expected to become an alternative to heart transplantation for severe heart failure. It is now possible to produce large numbers of human pluripotent stem cells (hPSCs) and eliminate non-cardiomyocytes, including residual undifferentiated hPSCs, which can cause teratoma formation after transplantation
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The alpha-1A adrenergic receptor regulates mitochondrial oxidative metabolism in the mouse heart J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-02-06 Peyton B. Sandroni, Melissa A. Schroder, Hunter T. Hawkins, Julian D. Bailon, Wei Huang, James T. Hagen, McLane Montgomery, Seok J. Hong, Andrew L. Chin, Jiandong Zhang, Manoj C. Rodrigo, Boa Kim, Paul C. Simpson, Jonathan C. Schisler, Jessica M. Ellis, Kelsey H. Fisher-Wellman, Brian C. Jensen
The sympathetic nervous system regulates numerous critical aspects of mitochondrial function in the heart through activation of adrenergic receptors (ARs) on cardiomyocytes. Mounting evidence suggests that α1-ARs, particularly the α1A subtype, are cardioprotective and may mitigate the deleterious effects of chronic β-AR activation by shared ligands. The mechanisms underlying these adaptive effects
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Lin28a cardiomyocyte-specific modified mRNA translation system induces cardiomyocyte cell division and cardiac repair J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-01-30 Ajit Magadum, Jiacheng Sun, Neha Singh, Ann Anu Kurian, Elena Chepurko, Anthony Fargnoli, Roger Hajjar, Jianyi Zhang, Lior Zangi
The mammalian heart has a limited regenerative capacity. Previous work suggested the heart can regenerate during development and immediately after birth by inducing cardiomyocyte (CM) proliferation; however, this capacity is lost seven days after birth. modRNA gene delivery, the same technology used successfully in the two mRNA vaccines against SARS-CoV-2, can prompt cardiac regeneration, cardiovascular
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Glutamate 139 of tropomyosin is critical for cardiac thin filament blocked-state stabilization J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-01-22 Meaghan E. Barry, Michael J. Rynkiewicz, Elumalai Pavadai, Alex Viana, William Lehman, Jeffrey R. Moore
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Stem cell-based therapy in cardiac repair after myocardial infarction: Promise, challenges, and future directions J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-01-20 Wenjun Yan, Yunlong Xia, Huishou Zhao, Xiaoming Xu, Xinliang Ma, Ling Tao
Stem cells represent an attractive resource for cardiac regeneration. However, the survival and function of transplanted stem cells is poor and remains a major challenge for the development of effective therapies. As two main cell types currently under investigation in heart repair, mesenchymal stromal cells (MSCs) indirectly support endogenous regenerative capacities after transplantation, while induced
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Dual effect of cardiac FKBP12.6 overexpression on excitation-contraction coupling and the incidence of ventricular arrhythmia depending on its expression level J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-01-14 Marine Gandon-Renard, Almudena Val-Blasco, Célia Oughlis, Pascale Gerbaud, Florence Lefebvre, Susana Gomez, Clément Journé, Delphine Courilleau, Françoise Mercier-Nomé, Laetitia Pereira, Jean-Pierre Benitah, Ana Maria Gómez, Jean-Jacques Mercadier
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Downregulation of Wtap causes dilated cardiomyopathy and heart failure J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-01-14 Lei Shi, Xinzhi Li, Meiwei Zhang, Cong Qin, Zhiguo Zhang, Zheng Chen
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Corrigendum to “Donor cell-type specific paracrine effects of cell transplantation for post-infarction heart failure” [J Mol Cell Cardiol 47 (2009) 288–295] J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-01-11 Yasunori Shintani, Satsuki Fukushima, Anabel Varela-Carver, Joon Lee, Steven R. Coppen, Kunihiko Takahashi, Scott W. Brouilette, Kenta Yashiro, Cesare M.N. Terracciano, Magdi H. Yacoub, Ken Suzuki
Abstract not available
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Substrate stiffness promotes vascular smooth muscle cell calcification by reducing the levels of nuclear actin monomers J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-01-05 M.C. McNeill, F. Li Mow Chee, R. Ebrahimighaei, G.B. Sala-Newby, A.C. Newby, T. Hathway, A.S. Annaiah, S. Joseph, M. Carrabba, M. Bond
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Cholesterol-induced HRD1 reduction accelerates vascular smooth muscle cell senescence via stimulation of endoplasmic reticulum stress-induced reactive oxygen species J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-01-03 Linli Wang, Min Wang, Haiming Niu, Yaping Zhi, Shasha Li, Xuemin He, Zhitao Ren, Shiyi Wen, Lin Wu, Siying Wen, Rui Zhang, Zheyao Wen, Jing Yang, Ximei Zhang, Yanming Chen, Xiaoxian Qian, Guojun Shi
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Impact of age and sex on myelopoiesis and inflammation during myocardial infarction J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2024-01-01 Babunageswararao Kanuri, Priosmita Biswas, Albert Dahdah, Andrew J. Murphy, Prabhakara R. Nagareddy
Of all the different risk factors known to cause cardiovascular disease (CVD), age and sex are considered to play a crucial role. Aging follows a continuum from birth to death, and therefore it inevitably acts as a risk for CVD. Along with age, sex differences have also been shown to demonstrate variations in immune system responses to pathological insults. It has been widely perceived that females
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Cardiac maturation J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-12-30 Tomoya Sakamoto, Daniel P. Kelly
The heart undergoes a dynamic maturation process following birth, in response to a wide range of stimuli, including both physiological and pathological cues. This process entails substantial re-programming of mitochondrial energy metabolism coincident with the emergence of specialized structural and contractile machinery to meet the demands of the adult heart. Many components of this program revert
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The novel antibody fusion protein rhNRG1-HER3i promotes heart regeneration by enhancing NRG1-ERBB4 signaling pathway J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-12-26 Xuemei Wang, Hao Wu, Luxun Tang, Wenbin Fu, Yanji He, Chunyu Zeng, Wei Eric Wang
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mTORC1 regulates the metabolic switch of postnatal cardiomyocytes during regeneration J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-12-23 Wyatt G. Paltzer, Timothy J. Aballo, Jiyoung Bae, Corey G.K. Flynn, Kayla N. Wanless, Katharine A. Hubert, Dakota J. Nuttall, Cassidy Perry, Raya Nahlawi, Ying Ge, Ahmed I. Mahmoud
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Age-related structural and functional changes of the intracardiac nervous system J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-12-14 Eliza Sassu, Gavin Tumlinson, Dragana Stefanovska, Marbely C. Fernández, Pia Iaconianni, Josef Madl, Tomás A. Brennan, Manuel Koch, Breanne A. Cameron, Sebastian Preissl, Ursula Ravens, Franziska Schneider-Warme, Peter Kohl, Callum M. Zgierski-Johnston, Luis Hortells
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Mechanistic target of rapamycin in regulating macrophage function in inflammatory cardiovascular diseases J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-11-30 MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
The mechanistic target of rapamycin (mTOR) is evolutionarily conserved from yeast to humans and is one of the most fundamental pathways of living organisms. Since its discovery three decades ago, mTOR has been recognized as the center of nutrient sensing and growth, homeostasis, metabolism, life span, and aging. The role of dysregulated mTOR in common diseases, especially cancer, has been extensively
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Classification of regulatory T cells and their role in myocardial ischemia-reperfusion injury J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-11-23 Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Myocardial ischemia-reperfusion injury (MIRI) is closely related to the final infarct size in acute myocardial infarction (AMI). Therefore, reducing MIRI can effectively improve the prognosis of AMI patients. At the same time, the healing process after AMI is closely related to the local inflammatory microenvironment. Regulatory T cells (Tregs) can regulate various physiological and pathological immune
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Dual mode of action of IP3-dependent SR-Ca2+ release on local and global SR-Ca2+ release in ventricular cardiomyocytes J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-11-20 Caroline Egger, Miguel Fernandez-Tenorio, Joaquim Blanch, Radoslav Janicek, Marcel Egger
In heart muscle, the physiological function of IP3-induced Ca2+ release (IP3ICR) from the sarcoplasmic reticulum (SR) is still the subject of intense study. A role of IP3ICR may reside in modulating Ca2+-dependent cardiac arrhythmogenicity. Here we observe the propensity of spontaneous intracellular Ca2+ waves (SCaW) driven by Ca2+-induced Ca2+ release (CICR) in ventricular myocytes as a correlate
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Cardiac myosin-binding protein C N-terminal interactions with myosin and actin filaments: Opposite effects of phosphorylation and M-domain mutations J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-11-24 Fiona L. Wong, Thomas A. Bunch, Victoria C. Lepak, Allison L. Steedman, Brett A. Colson
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Corrigendum to “Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy” [Journal: Molecular of and Cellular Cardiology (2019) May 130;160–169] J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-11-23 Bereketeab Haileselassie, Riddhita Mukherjee, Amit U. Joshi, Brooke A. Napier, Liliana M. Massis, Nicolai Patrick Ostberg, Bruno B. Queliconi, Denise Monack, Daniel Bernstein, Daria Mochly-Rosen
Abstract not available
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Targeting heat shock protein 47 alleviated doxorubicin-induced cardiotoxicity and remodeling in mice through suppression of the NLRP3 inflammasome J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-11-22 Wenke Shi, Jiaojiao Chen, Nan Zhao, Yun Xing, Shiqiang Liu, Mengya Chen, Wenxi Fang, Tong Zhang, Lanlan Li, Heng Zhang, Min Zhang, Xiaofeng Zeng, Si Chen, Shasha Wang, Saiyang Xie, Wei Deng
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Macrophage KLF15 prevents foam cell formation and atherosclerosis via transcriptional suppression of OLR-1 J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-11-18 Zheng-Kun Song, Li Zhao, De-Shen Liu, Ling-Na Zhao, Qin-Bao Peng, Zi-Yao Li, Jia-Yong Wu, Si-Kai Chen, Fang-Ze Huang, Xing Chen, Tian-Xiao Lin, Li Guan, Wei-Peng Meng, Jia-Wei Guo, Yue-Nian Su, Xiao-Xia He, Si-Jia Liang, Peng Zhu, Shao-Yi Zheng, Song-Lin Du, Xiu Liu
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β-hydroxybutyrate administered at reperfusion reduces infarct size and preserves cardiac function by improving mitochondrial function through autophagy in male mice J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-11-16 Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
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Profiling cardiomyocytes at single cell resolution reveals COX7B could be a potential target for attenuating heart failure in cardiac hypertrophy J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-11-17 Shi Chen, Kui Wang, Jingyu Wang, Xiao Chen, Menghao Tao, Dan Shan, Xiumeng Hua, Shengshou Hu, Jiangping Song
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Automated spatially targeted optical micro proteomics identifies fibroblast- and macrophage-specific regulation of myocardial infarction scar maturation in rats J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-11-09 Venkatesh Mallikarjun, Bocheng Yin, Laura R. Caggiano, Sydney Blimbaum, Caitlin M. Pavelec, Jeffrey W. Holmes, Sarah E. Ewald
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Determinants of electrical propagation and propagation block in Arrhythmogenic Cardiomyopathy J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-11-11 Qianru Jin, Keel Yong Lee, Zoja Selimi, Daisuke Shimura, Ethan Wang, John F. Zimmerman, Robin M. Shaw, Jan P. Kucera, Kevin Kit Parker, Jeffrey E. Saffitz, Andre G. Kleber
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Visualization of cardiac thick filament dynamics in ex vivo heart preparations J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-11-02 Colleen M. Kelly, Jody L. Martin, Molly Coseno, Michael J. Previs
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Epicardial deletion of Sox9 leads to myxomatous valve degeneration and identifies Cd109 as a novel gene associated with valve development J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-11-05 Andrew B. Harvey, Renélyn A. Wolters, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
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The characteristics of proliferative cardiomyocytes in mammals J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-11-01 Xinyue Yang, Liangpeng Li, Chunyu Zeng, Wei Eric Wang
Better understanding of the mechanisms regulating the proliferation of pre-existing cardiomyocyte (CM) should lead to better options for regenerating injured myocardium. The absence of a perfect research model to definitively identify newly formed mammalian CMs is lacking. However, methodologies are being developed to identify and enrich proliferative CMs. These methods take advantages of the different
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Clustering properties of the cardiac ryanodine receptor in health and heart failure J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-10-27 Helen M.M. Waddell, Valeria Mereacre, Francisco J. Alvarado, Michelle L. Munro
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Retraction notice to “Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction” [Journal of Molecular and Cellular Cardiology 50 (2011) 107-116] J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-10-28 Asli F. Ceylan-Isik, Nair Sreejayan, Jun Ren
Abstract not available
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Glimepiride, a novel soluble epoxide hydrolase inhibitor, protects against heart failure via increasing epoxyeicosatrienoic acids J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-10-21 Chengcheng Zhao, Xiangrui Jiang, Liyuan Peng, Yan Zhang, Huihui Li, Qiumeng Zhang, Yinhui Wang, Feipu Yang, Junfang Wu, Zheng Wen, Zuowen He, Jingshan Shen, Chen Chen, Dao Wen Wang
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Computational insight into energy control balance by Ca2+ and cAMP-PKA signaling in pacemaker cells J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-10-21 Savyon Mazgaoker, Yael Yaniv
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Loss of TIMP3, but not TIMP4, exacerbates thoracic and abdominal aortic aneurysm J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-10-14 Mei Hu, Ilamaran Meganathan, Jiechun Zhu, Rodrick MacArthur, Zamaneh Kassiri
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Characterization of heterozygous and homozygous mouse models with the most common hypertrophic cardiomyopathy mutation MYBPC3c.2373InsG in the Netherlands J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-10-14 Sarah Hilderink, Maike Schuldt, Max Goebel, Valentijn J. Jansen, Emmy Manders, Stan Moorman, Larissa M. Dorsch, Frank G. van Steenbeek, Jolanda van der Velden, Diederik W.D. Kuster
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Profibrotic COVID-19 subphenotype exhibits enhanced localized ER-dependent HSP47+ expression in cardiac myofibroblasts in situ J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-10-14 Elizabeth R. Jacobs, Gracious R. Ross, Nathan Padilla, Amy Y. Pan, Melodee Liegl, Andrii Puzyrenko, Shuping Lai, Qiang Dai, Nnamdi Uche, Jason C. Rubenstein, Paula E. North, El-Sayed H. Ibrahim, Yunguang Sun, Juan C. Felix, Hallgeir Rui, Ivor J. Benjamin
We recently described a subgroup of autopsied COVID-19 subjects (∼40%), termed ‘profibrotic phenotype,’ who exhibited clusters of myofibroblasts (Mfbs), which were positive for the collagen-specific chaperone heat shock protein 47 (HSP47+) in situ. This report identifies increased, localized (hot spot restricted) expression of αSMA, COLα1, POSTN and FAP supporting the identity of HSP47+ cells as myofibroblasts
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CaMKII, ‘jack of all trades’ in inflammation during cardiac ischemia/reperfusion injury J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-10-07 Wenjia Zhang, Erdan Dong, Junxia Zhang, Yan Zhang
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Current optimized strategies for stem cell-derived extracellular vesicle/exosomes in cardiac repair J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-10-04 Rongrong Wu, Xinyang Hu, Jian’an Wang
Ischemic heart diseases remain the leading cause of death globally, and stem cell-based therapy has been investigated as a potential approach for cardiac repair. Due to poor survival and engraftment in the cardiac ischemic milieu post transplantation, the predominant therapeutic effects of stem cells act via paracrine actions, by secreting extracellular vesicles (EVs) and/or other factors. Exosomes
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Activation of neurokinin-III receptors modulates human atrial TASK-1 currents J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-10-02 Felix Wiedmann, Amelie Paasche, Jendrik Nietfeld, Manuel Kraft, Anna L. Meyer, Gregor Warnecke, Matthias Karck, Norbert Frey, Constanze Schmidt
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Role of ventrolateral part of ventromedial hypothalamus in post-myocardial infarction cardiac dysfunction induced by sympathetic nervous system J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-10-01 Zihan Liu, Zhihao Liu, Xiao Xu, Yuyang Zhou, Hu Chen, Huixin Zhou, Zeyan Li, Fuding Guo, Zhen Zhou, Yuhong Wang, Meng Wang, Yueyi Wang, Liping Zhou, Hong Jiang, Lilei Yu
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Caveolae-associated cAMP/Ca2+-mediated mechano-chemical signal transduction in mouse atrial myocytes J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-10-05 Roman Y. Medvedev, Daniel G.P. Turner, Frank C. DeGuire, Vladislav Leonov, Di Lang, Julia Gorelik, Francisco J. Alvarado, Vladimir E. Bondarenko, Alexey V. Glukhov
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Nonsense mediated decay factor UPF3B is associated with cMyBP-C haploinsufficiency in hypertrophic cardiomyopathy patients J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-10-04 Valentin Burkart, Kathrin Kowalski, Alina Disch, Denise Hilfiker-Kleiner, Sean Lal, Cristobal dos Remedios, Andreas Perrot, Andre Zeug, Evgeni Ponimaskin, Maike Kosanke, Oliver Dittrich-Breiholz, Theresia Kraft, Judith Montag
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An improved method reveals the dual role of Tnni3k in promoting S-phase entry while suppressing cell division in cardiomyocytes J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-09-26 Lin Liu, Rich Gang Li, James F. Martin
Abstract not available
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To block or not to block: Targeting SK channels in diseased hearts J. Mol. Cell. Cardiol. (IF 5.0) Pub Date : 2023-09-23 Dmitry Terentyev, Andriy E. Belevych, Bum-Rak Choi, Shanna Hamilton
Abstract not available