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Bedside Ultrasound in the Management of Cardiorenal Syndromes: An Updated Review. Cardiorenal Med. (IF 3.8) Pub Date : 2023-11-18 Eduardo R Argaiz,Gregorio Romero-Gonzalez,Philippe Rola,Rory Spiegel,Korbin H Haycock,Abhilash Koratala
BACKGROUND Cardiorenal syndromes constitute a spectrum of disorders involving heart and kidney dysfunction modulated by a complex interplay of neurohormonal, inflammatory and hemodynamic derangements. The management of such patients often poses a diagnostic and therapeutic challenge to physicians owing to gaps in understanding of pathophysiology, paucity of objective bedside diagnostic tools and individual
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QTc interval prolongation independently associates with FGF23 and predicts mortality in predialysis CKD. Cardiorenal Med. (IF 3.8) Pub Date : 2023-11-14 Tabo Sikaneta,Natalie Ho,Antonio Bellasi,Sara Mahdav,Hulya Taskapan,Anton Svendrovski,Bhavanesh Makanjee,Jason Roberts,George Wu,Bharat Nathoo,Paul Tam
INTRODUCTION QTc interval prolongation is increasingly frequent as CKD advances and predicts death in dialysis. However, predictors and mortality-risk in predialysis CKD are understudied. FGF23 induces left ventricular hypertrophy (LVH) which is associated with QTc interval prolongation and death, suggesting a possible pathway from FGF23 to death that entails LVH and QTc prolongation. We looked for
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Association of chronic kidney disease with cardiovascular disease in cancer patients: a cross-sectional study. Cardiorenal Med. (IF 3.8) Pub Date : 2023-10-14 An-Bang Liu,Dan Zhang,Ting-Ting Meng,Yu Zhang,Peng Tian,Jian-Lin Chen,Yan Zheng,Guo-Hai Su
INTRODUCTION Due to the cardiotoxicity of cancer treatment and traditional risk factors for cardiovascular disease (CVD) such as obesity, diabetes, dyslipidemia, and hypertension, cancer patients are at higher risk of developing CVD. However, limited research exists on the correlation between chronic kidney disease (CKD) and CVD risk in cancer patients. METHODS This cross-sectional study selected cancer
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Low lean tissue index and muscle strength combined with high fat tissue index are associated with cardiovascular disease-related hospitalisation in patients on haemodialysis. Cardiorenal Med. (IF 3.8) Pub Date : 2023-10-13 Maolu Tian,Qin Lan,Jing Yuan,Pinghong He,Fangfang Yu,Changzhu Long,Yan Zha
INTRODUCTION The combined clinical impact of muscle mass, muscle function and adipose mass on hospitalisation events, especially those that have exact causes, such as cardiovascular diseases (CVDs), had been rarely studied in patients on haemodialysis (HD). This study aimed to determine the influence of lean tissue index (LTI), fat tissue index (FTI) and hand grip strength (HGS) on the risk of CVD-related
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Mild renal function impairment and long-term outcomes in patients with three-vessel coronary artery disease: a cohort study. Cardiorenal Med. (IF 3.8) Pub Date : 2023-10-12 Guyu Zeng,Deshan Yuan,Peizhi Wang,Tianyu Li,Lin Jiang,Lianjun Xu,Jian Tian,Xueyan Zhao,Xinxing Feng,Dong Wang,Yin Zhang,Kai Sun,Jingjing Xu,Ru Liu,Bo Xu,Wei Zhao,Rutai Hui,Runlin Gao,Lei Song,Jinqing Yuan
BACKGROUND Limited data are available on the long-term impact of mild renal dysfunction (eGFR 60-89 ml/min/1.73m2) in patients with three-vessel coronary disease (3VD). METHODS A total of 5,272 patients with 3VD undergoing revascularization were included and were categorized into 3 groups: normal renal function (eGFR ≥90 ml/min/1.73m2, n=2352), mild renal dysfunction (eGFR 60-89, n=2501) and moderate
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Key considerations regarding the renal risks of iodinated contrast media: the nephrologist's role. Cardiorenal Med. (IF 3.8) Pub Date : 2023-09-27 Ravindra Mehta,David Sorbo,Federico Ronco,Claudio Ronco
BACKGROUND The administration of iodinated contrast medium during diagnostic and therapeutic procedures has always been associated with the fear of causing acute kidney injury (AKI) or an exacerbation of chronic kidney disease (CKD). This has led, on the one hand, to the deterrence, when possible, of the use of contrast medium (preferring other imaging methods with the risk of loss of diagnostic power)
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Etelcalcetide inhibits the progression of left atrial volume index compared to alfacalcidol in hemodialysis patients. Cardiorenal Med. (IF 3.8) Pub Date : 2023-09-20 Katharina Dörr,Roman Reindl-Schwaighofer,Matthias Lorenz,Rodrig Marculescu,Dietrich Beitzke,Sebastian Hödlmoser
INTRODUCTION Increased left atrial (LA) size is a risk factor for cardiovascular events and all-cause mortality. It is closely related to left ventricular hypertrophy and chronic volume overload, both of which are common in hemodialysis. Calcimimetic treatment with Etelcalcetide (ETL) previously showed an inhibitory effect on left ventricular mass index (LVMI) progression in this population. METHODS
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The Worsening Renal Perfusion Index predicts the prognoses of heart failure patients treated with sacubitril/valsartan. Cardiorenal Med. (IF 3.8) Pub Date : 2023-09-14 Wan-Tseng Hsu,Yu-Yang Cheng,Tsun-Yu Yang,Chao-Kai Chang,Yi-Hsuan Lin,Chii-Ming Lee,Tao-Min Huang
INTRODUCTION Sacubitril/valsartan (S/V) reduces all-cause mortality in patients with heart failure with reduced ejection fraction (HFrEF), but it may decline their estimated glomerular filtration rates (eGFR). In addition to eGFR, this clinical study aimed to develop a blood urea nitrogen (BUN)-based index to evaluate the status of renal perfusion and then identify predictors of all-cause death or
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Circulating metabolites and cardiovascular disease in Asians with chronic kidney disease. Cardiorenal Med. (IF 3.8) Pub Date : 2023-09-05 Jiashen Cai,Crystal Chun Yuen Chong,Ching Yu Cheng,Cynthia Ciwei Lim,Charumathi Sabanayagam
Introduction Chronic kidney disease (CKD) is a growing public health problem, with significant burden of cardiovascular disease and mortality. The risk of cardiovascular disease in CKD is elevated beyond that predicted by traditional cardiovascular risk factors, suggesting that other factors may account for this increased risk. Through metabolic profiling, this study aimed to investigate the associations
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Relation of Mechanical ventilation to Acute Kidney injury in Myocardial Infarction Patients. Cardiorenal Med. (IF 3.8) Pub Date : 2023-08-28 Shir Frydman,Ophir Freund,Lior Zornitzki,Shmuel Banai,Yacov Shacham
Introduction- Acute kidney injury (AKI) is a common and serious complication in critically ill patients, particularly those with ST elevation myocardial infarction (STEMI). Mechanical ventilation (MV) is often needed when respiratory deterioration occurs and was continuously associated with higher risk for AKI. Whether MV is an independent predictor for AKI in STEMI patients has not been evaluated
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The War of Attrition on Diuretic Resistance: We Need to Open a Third Front. Cardiorenal Med. (IF 3.8) Pub Date : 2023-08-28 Amir Kazory
n/a.
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Development and validation of a nomogram for predicting all-cause mortality in patients with hemodialysis having pulmonary hypertension. Cardiorenal Med. (IF 3.8) Pub Date : 2023-08-28 Huimin Wu,Chunyan Huan,Yue Hu,Shengjue Xiao,Tao Xu,Minjia Guo,Xiaotong Wang,Ailin Liu,Jiayi Sun,Chunqing Wang,Jia Wang,Hong Zhu,Defeng Pan
INTRODUCTION Patients with end-stage renal disease receiving hemodialysis (HD) have a high morbidity and mortality rate associated with pulmonary hypertension (PH). A nomogram was developed to predict all-cause mortality in HD patients with PH. In this study, we aimed to validate the usefulness of this nomogram. METHODS A total of 274 HD patients with PH were hospitalized at the Affiliated Hospital
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The additive effect of Left ventricular filling pressure and renal function on long term prognosis of high risk patients undergoing coronary angiography. Cardiorenal Med. (IF 3.8) Pub Date : 2023-08-21 Nicholay Teodorovich,Yakov Fabrikant,Gera Gandelman,Moshe Swissa,Michael Jonas,Jacob George,Sara Shimoni
BBACKGROUND Impaired relaxation is the earliest manifestation of ischemic cascade. Risk factors and renal function abnormalities are associated with coronary disease and diastolic dysfunction as well. We aimed to study the association of noninvasive assessment of LV filling pressures and renal function with mortality in high risk patients undergoing coronary angiography. PATIENTS AND METHODS An observational
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Left Ventricular Function in Patients on Maintenance Hemodialysis : A Three-Dimensional Speckle-Tracking Imaging Study. Cardiorenal Med. (IF 3.8) Pub Date : 2023-08-16 Meihua Chen,Xiaojuan Chen,Hanyin Huang,Yunpeng Wei,Lehua Wang,Xuning Huang
INTRODUCTION Although maintenance hemodialysis (MHD) in end-stage renal disease (ESRD) appears to induce some risk factors and strengthen cardiac function, the morbidity of ESRD patients receiving hemodialysis remains high. This study aimed to identify left ventricular (LV) structural and functional abnormalities in ESRD patients on MHD using three-dimensional speckle-tracking imaging (3D-STI). METHODS
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Peritoneal and Urinary Sodium Removal in Refractory Congestive Heart Failure Patients Included in an Ambulatory Peritoneal Dialysis Program: Valuable for Monitoring the Course of the Disease. Cardiorenal Med. (IF 3.8) Pub Date : 2023-08-16 Gema Miñana,Miguel González-Rico,Rafael de la Espriella,Daniel González-Sánchez,Marco Montomoli,Eduardo Núñez,Agustín Fernández-Cisnal,Sandra Villar,Jose Luis Górriz,Julio Núñez
INTRODUCTION Spot urinary sodium emerged as a useful parameter for assessing decongestion in patients with congestive heart failure (CHF). Growing evidence endorses the therapeutic role of continuous ambulatory peritoneal dialysis (CAPD) in patients with refractory CHF and kidney disease. We aimed to examine the long-term trajectory of urinary, peritoneal, and total (urinary plus peritoneal) sodium
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Effects of Ulinastatin on Postoperative Renal Function in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass: A Prospective Cohort Study with 10-Year Follow-Up. Cardiorenal Med. (IF 3.8) Pub Date : 2023-06-14 Huanran Lv,Qian Li,Yuda Fei,Peng Zhang,Lihuan Li,Jia Shi,Hong Lv
INTRODUCTION The present study aimed to explore the potential effect of ulinastatin on renal function and long-term survival in patients receiving cardiac surgery with cardiopulmonary bypass (CPB). METHODS This prospective cohort study was conducted at Fuwai Hospital, Beijing, China. Ulinastatin was applied after induction anesthesia. The primary outcome was the rate of new-onset postoperative acute
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Serum IGFBP7 deriving from spleen and lung could be used for early recognition of cardiac surgery-associated acute kidney injury. Cardiorenal Med. (IF 3.8) Pub Date : 2023-06-13 Yimei Wang,Bo Shena,Xuesen Cao,Zhihui Lu,Yang Zhang,Bowen Zhu,Weidong Zhang,Yiqin Shi,Jialin Wang,Yi Fang,Nana Song,Yang Li,Xialian Xu,Ping Jia,Xiaoqiang Ding,Shuan Zhao
INTRODUCTION The utility of arithmetic product of urinary tissue metalloproteinase inhibitor 2 (TIMP2) and insulin-like growth factor-binding protein 7 (IGFBP7) concentrations has been widely accepted on early diagnosis of acute kidney injury (AKI). However, which organ is the main source of those two factors and how the concentration of IGFBP7 and TIMP2 changed in serum during AKI still remain to
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Prevalence, Clinical Characteristics, and Prognostic Impact of Kidney Disease on Heart Failure Patients: An Observational Study of the Colombian Heart Failure Registry. Cardiorenal Med. (IF 3.8) Pub Date : 2023-05-22 Juan David López-Ponce de León,Juan Esteban Gómez-Mesa,Clara Saldarriaga,Luis Eduardo Echeverría,Alejandro Posada-Bastidas,Juan Camilo García,Alejandro David Ochoa-Morón,Balkis Rolong,Fernando Manzur-Jatin,José Ignacio Mosquera-Jiménez,Oscar Alfredo Pacheco-Jiménez,Álvaro Hernán Rodríguez-Cerón,Patricia Rodríguez-Gómez,Fernando Rivera-Toquica,Alex Rivera-Toquica
INTRODUCTION Chronic kidney disease (CKD) represents one of the most frequent comorbidities observed in heart failure (HF) patients and has been observed to increase this population's risk of adverse outcomes. Nevertheless, evidence analyzing kidney dysfunction in HF is scarce in Latin American populations. We aimed to analyze the prevalence of kidney dysfunction and assess its association with mortality
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New Miniaturized System for Ultrafiltration: Rationale and Design of a Single-Center, Crossover, Randomized, Open-Label, Pilot Study Protocol. Cardiorenal Med. (IF 3.8) Pub Date : 2023-05-15 Thiago Reis,Luca Sgarabotto,Alessandra Brendolan,Anna Lorenzin,Valentina Corradi,Nicola Marchionna,Monica Zanella,Claudio Ronco
INTRODUCTION Fluid overload and congestion are common features in patients with heart failure and are associated with negative clinical outcomes. Therapies for these conditions are diuretic-centered but frequently fail to achieve patient-adequate hydration status, prompting the use of extracorporeal ultrafiltration. Artificial Diuresis 1 (AD1) is a miniaturized, portable, and wearable system designed
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Soluble CD14 and osteoprotegerin associate with ankle-brachial index as a measure of arterial stiffness in patients with mild to moderate chronic kidney disease in a five-year prospective study. Cardiorenal Med. (IF 3.8) Pub Date : 2023-05-15 Senka Sendic,Ladan Mansouri,Mun-Gwan Hong,Jochen M Schwenk,Maria J Eriksson,Britta Hylander,Joachim Lundahl,Stefan H Jacobson
Introduction Vascular lesions and arterial stiffness appear at early stages of chronic kidney disease (CKD) and follow an accelerated course with disease progression, contributing to high cardiovascular mortality. There are limited prospective data on mechanisms contributing to progression of arterial stiffness in mild to moderate CKD (stages 2-3). Methods We applied an affinity proteomics approach
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Artificial Diuresis: animal studies on efficacy and safety of a new miniaturized device for extracorporeal ultrafiltration Cardiorenal Med. (IF 3.8) Pub Date : 2023-03-28
Introduction. We have recently developed a new miniaturized device for extracorporeal ultrafiltration to be used in patients with fluid overload: Artificial Diuresis-1, or AD1 (Medica S.p.A., Medolla, Italy). The device has a reduced priming volume and operates at very low pressure and flow regimes and is designed to perform extracorporeal UF at bedside. After accurate experiments carried out in vitro
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Prognosis of Patients with Acute Kidney Injury due to Type 1 Cardiorenal Syndrome Receiving Continuous Renal Replacement Therapy Cardiorenal Med. (IF 3.8) Pub Date : 2023-03-24 Yusuke Watanabe, Tsutomu Inoue, Shintaro Nakano, Hirokazu Okada
Introduction The prognosis of patients with acute kidney injury (AKI) caused by type 1 cardiorenal syndrome (CRS) requiring continuous renal replacement therapy (CRRT) is unclear. We investigated the in-hospital mortality and prognostic factors in these patients. Methods We retrospectively identified 154 consecutive adult patients who received CRRT for AKI caused by type 1 CRS between January 1, 2013
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Usefulness of a Novel Vascular Access Management Method Using a Laser Blood Flowmeter Cardiorenal Med. (IF 3.8) Pub Date : 2023-03-23 Moe Kojima, Naoya Tanabe, Yu Kojima, Koichi Tamura, Hiroo Takahashi, Jun Ito
Introduction: Various methods for vascular access (VA) management have been studied. We investigated the usefulness a new, simple, and quantitative VA management method using the Pocket LDF® laser blood flowmeter (hereinafter “LDF”) that non-invasively measures peripheral circulation flow. Methods: Peripheral circulation flow was measured in 82 patients (43 men) on maintenance hemodialysis with an
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The relationship between vascular aging phenotypes and renal damage among individuals with type 2 diabetes Cardiorenal Med. (IF 3.8) Pub Date : 2023-02-24
Objective: To investigate the relationship between vascular aging (VA) phenotypes and renal damage in type 2 diabetic population. Methods: In this cross-sectional study, we included 8,141 individuals with type 2 diabetes who participated in the Kailuan Study during 2010 to 2018 and completed the brachial-ankle pulse wave velocity (baPWV) assessment for arterial stiffness, an indicator for VA. The age-
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Aortic Stenosis and Aortic Valve Replacement Among Patients with Chronic Kidney Disease: A Narrative Review Cardiorenal Med. (IF 3.8) Pub Date : 2023-02-22 Frederick Berro Rivera, Maria Victoria Valenzona Cu, Sharmaine Jesselyn Cua, Deogracias Villa De Luna, Edgar V. Lerma, Peter A. McCullough, Amir Kazory, Fareed Moses S. Collado
Background: Aortic stenosis (AS) can present with dyspnea, angina, syncope, and palpitations and this presents a diagnostic challenge as chronic kidney disease (CKD) and other commonly found comorbid conditions may present similarly. While medical optimization is an important aspect in management, aortic valve replacement (AVR) by surgical aortic valve replacement (SAVR) or transcatheter aortic valve
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Impact of dapagliflozin treatment on serum sodium concentrations in acute heart failure Cardiorenal Med. (IF 3.8) Pub Date : 2023-02-20
Introduction The dynamics of serum sodium are important in acute heart failure (AHF), and hyponatremia is associated with a poor prognosis. The effect of sodium-glucose cotransporter type 2 inhibitors (SGLT2i) on serum sodium concentrations in AHF is unknown. Methods In a single-centre, controlled, randomized study, patients were prescribed dapagliflozin in addition to standard treatment during the
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One heartbeat away from a prediction model for cardiovascular diseases in patients with chronic kidney disease: a systematic review Cardiorenal Med. (IF 3.8) Pub Date : 2023-02-20
Background: Patients with chronic kidney disease (CKD) have a high risk of cardiovascular disease (CVD). Prediction models, combining clinical and laboratory characteristics, are commonly used to estimate an individual’s CVD risk. However, these models are not specifically developed for patients with CKD and may therefore be less accurate. In this review we aim to give an overview of CVD prognostic
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Transcatheter Aortic Valve Replacement (TAVR)-associated Acute Kidney Injury: An Update Cardiorenal Med. (IF 3.8) Pub Date : 2023-02-17 Frederick Berro Rivera, Abdullah Al-Abcha, Marie Francesca Mapua Ansay, John Vincent Usita Magalong, Vincent Anthony Songheng Tang, Hannah May Ona, Karissa Alyanna Miralles, Rausche Sausa, Rodie Abram Florendo Uy, Edgar V. Lerma, Fareed Moses S. Collado, Peter A. McCullough, Annabelle Santos Volgman
Background: Transcatheter Aortic Valve Replacement (TAVR) is a relatively novel minimally invasive procedure for the treatment of symptomatic patients with severe aortic stenosis. Although it has been proven effective in improving mortality and quality of life, TAVR is associated with serious complications, such as acute kidney injury (AKI). Summary: TAVR-associated AKI is likely due to several factors
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The Science of Extracorporeal Ultrafiltration: Introducing a Novel Miniaturized Device Cardiorenal Med. (IF 3.8) Pub Date : 2023-02-14 Luca Sgarabotto, Amir Kazory, Alessandra Brendolan, Luca Di Lullo, Monica Zanella, Claudio Ronco
Introduction. Fluid overload has been associated with untoward outcomes in a variety of clinical settings. Isolated extracorporeal ultrafiltration (UF) allows for mechanical extraction of excess fluid and optimization of volume status without the established risks associated with use of high dose diuretics. Conventional machines for renal replacement therapy can be used to perform isolated UF. However
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Tackling Congestion in Acute Heart Failure; Is It the Primetime for “Combo Diuretic Therapy”? Cardiorenal Med. (IF 3.8) Pub Date : 2023-02-14 Amir Kazory, Claudio Ronco
Symptoms and signs of congestion are the primary reason for hospitalization of patients with acute heart failure. Efficient fluid and sodium removal remains the main goal of therapy and loop diuretics are the recommended agents in this setting. However, the therapeutic response to these medications is known to be variable and a significant subset of patients are discharged from the hospital with residual
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Vascular calcification exacerbates abnormal blood pressure variability in chronic kidney disease: a “two-step” study in rats Cardiorenal Med. (IF 3.8) Pub Date : 2023-02-10
Introduction Vascular calcification (VC) is a common complication of chronic kidney disease (CKD) with poor cardiovascular prognosis. The aim of this study is to explore the impact of VC on blood pressure variability (BPV) in animal models of CKD. Methods Two optimal modelling methods, adenine high-phosphorus (HP) diet + calcitriol and 5/6 nephrectomy (Nx) + HP diet + calcitriol, for CKD-VC were chosen
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Vascular calcification exacerbates abnormal blood pressure variability in chronic kidney disease: a "two-step" study in rats. Cardiorenal Med. (IF 3.8) Pub Date : 2023-02-10 Yuqin Xiong,Yang Yu,Ke Huang,Ruoxi Liao,Liya Wang,Zhuyun Zhang,Jiameng Li,Zheng Qin,Si Sun,Yupei Li,Baihai Su
Introduction Vascular calcification (VC) is a common complication of chronic kidney disease (CKD) with poor cardiovascular prognosis. The aim of this study is to explore the impact of VC on blood pressure variability (BPV) in animal models of CKD. Methods Two optimal modelling methods, adenine high-phosphorus (HP) diet + calcitriol and 5/6 nephrectomy (Nx) + HP diet + calcitriol, for CKD-VC were chosen
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Prognosis of heart valve calcification on cardiovascular events in hemodialysis patients without central venous catheters Cardiorenal Med. (IF 3.8) Pub Date : 2023-02-01 Xiao-mei Huang, Yi Zhang, Min Du, Lian-qing Gu, Hui-ling Fu, Fen Yu, Li Xu, Jing-jing Li, Yin Wang, Xiao-feng Sun
Introduction: Heart valvular calcification (HVC) is an important predictor of cardiovascular events (CEs) and all-cause mortality in dialysis patients. Patients in the early stage of dialysis or those with central venous catheters (CVCs) are also at high risk of cardiovascular and all-cause mortality. It could be a confounding factor for the prognosis of HVC on CE. Methods: From March 2017 to April
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Acknowledgement to Reviewers Cardiorenal Med. (IF 3.8) Pub Date : 2023-01-26
Cardiorenal Med 2023;13:1–
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Diuretics and ultrafiltration in heart failure Cardiorenal Med. (IF 3.8) Pub Date : 2023-01-11 Thiago Reis, Federico Ronco, Marlies Ostermann
Fluid overload is a risk factor for increased morbidity and mortality, especially in patients with heart disease. The treatment options for decongestion are limited to diuretics and mechanical fluid removal using ultrafiltration or renal replacement therapy. This paper provides an overview of the challenges of managing fluid overload, outlines the risks and benefits of different pharmacological options
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Rationale and need for simpler and effective miniaturized bedside ultrafiltration devices Cardiorenal Med. (IF 3.8) Pub Date : 2022-12-15 Claudio Ronco, Alessandra Brendolan, Luca Sgarabotto
Fluid overload in different acute or chronic clinical settings results in unfavorable outcomes. The use of restrictive strategies for fluid control or the use of diuretics is frequently ineffective and requires extracorporeal ultrafiltration for the removal of excess volume. These extracorporeal treatments are performed with bulky machinery and require highly specialized personnel. The creation of
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Acute and chronic cardiovascular consequences of acute kidney injury: a systematic review and meta-analysis. Cardiorenal Med. (IF 3.8) Pub Date : 2022-11-18 Lorenz De Clercq, Tim Ailliet, Hannah Schaubroeck, Eric A. J. Hoste
INTRODUCTIONː We examined whether patients with acute kidney injury (AKI) have a higher risk of developing atrial fibrillation (AF), heart failure (HF), acute coronary syndrome (ACS) and major adverse cardiac events (MACE) in the short- and long-term compared to patients without AKI, and if that risk is related to the severity of AKI. Furthermore, we investigated the influence of a cardiac event following
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Acute and chronic cardiovascular consequences of acute kidney injury: a systematic review and meta-analysis. Cardiorenal Med. (IF 3.8) Pub Date : 2022-11-18
INTRODUCTIONː We examined whether patients with acute kidney injury (AKI) have a higher risk of developing atrial fibrillation (AF), heart failure (HF), acute coronary syndrome (ACS) and major adverse cardiac events (MACE) in the short- and long-term compared to patients without AKI, and if that risk is related to the severity of AKI. Furthermore, we investigated the influence of a cardiac event following
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Extracorporeal Ultrafiltration for Acute Heart Failure Cardiorenal Med. (IF 3.8) Pub Date : 2022-11-02 Amir Kazory, Luca Sgarabotto, Claudio Ronco
Acute decompensated heart failure (ADHF) has the highest rate of hospital re-admission among all medical conditions and portends a significant financial burden on healthcare systems worldwide. Hospitalization for ADHF is primarily driven by congestion, with intravenous loop diuretics representing the cornerstone of therapy. However, it is well described that a significant subset of patients are discharged
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Extracorporeal Ultrafiltration for Acute Heart Failure Cardiorenal Med. (IF 3.8) Pub Date : 2022-11-02
Acute decompensated heart failure (ADHF) has the highest rate of hospital re-admission among all medical conditions and portends a significant financial burden on healthcare systems worldwide. Hospitalization for ADHF is primarily driven by congestion, with intravenous loop diuretics representing the cornerstone of therapy. However, it is well described that a significant subset of patients are discharged
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APOL1 G3 Variant Is Associated with Cardiovascular Mortality and Sudden Cardiac Death in Patients Receiving Maintenance Hemodialysis of European Ancestry Cardiorenal Med. (IF 3.8) Pub Date : 2022-10-28 Tae-Hwi Schwantes-An, Cassianne Robinson-Cohen, Sai Liu, Neil Zheng, Margaret Stedman, Leah Wetherill, Howard J. Edenberg, Matteo Vatta, Tatiana M. Foroud, Glenn M. Chertow, Sharon M. Moe
Introduction: The G1 and G2 variants in the APOL1 gene convey high risk for the progression of chronic kidney disease in African Americans. The G3 variant in APOL1 is more common in patients of European ancestry (EA); outcomes associated with this variant have not been explored previously in EA patients receiving dialysis. Methods: DNA was collected from approximately half of the patients enrolled
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APOL1 G3 Variant Is Associated with Cardiovascular Mortality and Sudden Cardiac Death in Patients Receiving Maintenance Hemodialysis of European Ancestry Cardiorenal Med. (IF 3.8) Pub Date : 2022-10-28
Introduction: The G1 and G2 variants in the APOL1 gene convey high risk for the progression of chronic kidney disease in African Americans. The G3 variant in APOL1 is more common in patients of European ancestry (EA); outcomes associated with this variant have not been explored previously in EA patients receiving dialysis. Methods: DNA was collected from approximately half of the patients enrolled
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Long-Term Prognostic Impact of Estimated Glomerular Filtration Rate on Admission in Patients Hospitalized for Acute Heart Failure Cardiorenal Med. (IF 3.8) Pub Date : 2022-10-25 Rafael de la Espriella, Jorge Navarro, Anna Mollar, Luis D’Marco, Patricia Palau, Gema Miñana, Pau Llácer, Enrique Santas, Raquel Heredia, Miguel González, José Luis Górriz, Pau Codina, Javier Díez, Antoni Bayés-Genís, Julio Núñez
Introduction: Although small-sample size studies have shown that basal alterations of estimated glomerular filtration rate (eGFR) are related to short- and mid-term higher mortality in acute heart failure (AHF), there is scarce information on the influence of an altered eGFR on long-term mortality and readmissions. Therefore, this multicenter study sought to investigate the relationship between eGFR
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Long-Term Prognostic Impact of Estimated Glomerular Filtration Rate on Admission in Patients Hospitalized for Acute Heart Failure Cardiorenal Med. (IF 3.8) Pub Date : 2022-10-25
Introduction: Although small-sample size studies have shown that basal alterations of estimated glomerular filtration rate (eGFR) are related to short- and mid-term higher mortality in acute heart failure (AHF), there is scarce information on the influence of an altered eGFR on long-term mortality and readmissions. Therefore, this multicenter study sought to investigate the relationship between eGFR
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The vascular disease of diabetic kidney disease Cardiorenal Med. (IF 3.8) Pub Date : 2022-10-24 Paolo Lentini, Luca Zanoli, Claudio Ronco, Claudia Benedetti, Antonino Previti, Giorgio Laudadio, Federica Vienna, Sofia Andrighetto, Valeria Fuso, Giovanni Gambaro
The incidence of cardiovascular disease (CVD) is increased in patients with diabetic kidney disease (DKD). Aortic stiffness is a well-accepted biomarker for cardiovascular (CV) events in all stages of CKD. The worldwide prevalence of diabetes continues to grow, as does the prevalence of DKD. Insulin resistance, hyperglycaemia, hypertension and the metabolic abnormalities of type-2 diabetes are all
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The vascular disease of diabetic kidney disease Cardiorenal Med. (IF 3.8) Pub Date : 2022-10-24
The incidence of cardiovascular disease (CVD) is increased in patients with diabetic kidney disease (DKD). Aortic stiffness is a well-accepted biomarker for cardiovascular (CV) events in all stages of CKD. The worldwide prevalence of diabetes continues to grow, as does the prevalence of DKD. Insulin resistance, hyperglycaemia, hypertension and the metabolic abnormalities of type-2 diabetes are all
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Estimation of Plasma Renin Activity on the Basis of Serum and Urinary Chloride Concentrations versus Sodium Concentrations Cardiorenal Med. (IF 3.8) Pub Date : 2022-10-10 Hajime Kataoka
Introduction: The present study examined the possible estimation of plasma renin activity (PRA) by serum and urinary concentrations of chloride vs. sodium in acute and chronic heart failure (HF). Methods: Data from 29 patients with acute HF (48% men;80.3±12 years-old) and 26 patients with recovery of HF after decongestive therapy (50% men;81.2±12 years-old) were analyzed. Blood and urine samples were
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Stanniocalcin 2 is upregulated by calcium-sensing receptor and protects human vascular smooth muscle cells from high phosphate-induced apoptosis Cardiorenal Med. (IF 3.8) Pub Date : 2022-10-10 Fen-fen Liu, Ai-hua Zhang, Hong-dong Huang, Xu Liu, Zong-li Diao, Dai Deng, Wen-hu Liu
Introduction Apoptosis of vascular smooth muscle cells induced by hyperphosphatemia is a critical mechanism of chronic kidney disease-related vascular disorders. The present study investigated whether extracellular calcium-sensing receptor (CaSR) regulates stanniocalcin 2 (STC2) expression in HAoSMCs in vitro and whether induced STC2 protects HAoSMCs from high phosphate-induced apoptosis. Methods and
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Association of cancer antigen 125 with long-term prognosis in light-chain cardiorenal amyloidosis Cardiorenal Med. (IF 3.8) Pub Date : 2022-10-10 Bifeng Wu, Jiaran Shi, Fangcong Yu, Yakui Wu, Xinran Tao, Tianming Xuan, Jinxiu Yang, Xingxiang Wang
Background: Light-chain (AL) cardiorenal amyloidosis has been characterized as type 5 cardiorenal syndrome with fluid overload and poor prognosis. Cancer antigen 125 (CA125) has the potential for use in evaluating fluid load and prognosis for heart failure. However, less details for CA125 in AL cardiorenal amyloidosis have been reported. Methods: Sixty patients diagnosed with AL cardiorenal amyloidosis
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Estimation of Plasma Renin Activity on the Basis of Serum and Urinary Chloride Concentrations versus Sodium Concentrations Cardiorenal Med. (IF 3.8) Pub Date : 2022-10-10
Introduction: The present study examined the possible estimation of plasma renin activity (PRA) by serum and urinary concentrations of chloride versus sodium in acute and chronic heart failure (HF). Methods: Data from 29 patients with acute HF (48% men; 80.3 ± 12 years) and 26 patients with recovery of HF after decongestive therapy (50% men; 81.2 ± 12 years) were analyzed. Blood and urine samples were
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Stanniocalcin 2 Is Upregulated by Calcium-Sensing Receptor and Protects Human Vascular Smooth Muscle Cells from High-Phosphate-Induced Apoptosis Cardiorenal Med. (IF 3.8) Pub Date : 2022-10-10
Introduction: Apoptosis of vascular smooth muscle cells induced by hyperphosphatemia is a critical mechanism of chronic kidney disease-related vascular disorders. The present study investigated whether extracellular calcium-sensing receptor (CaSR) regulates stanniocalcin 2 (STC2) expression in HAoSMCs and subsequently protects HAoSMCs from high-phosphate-induced apoptosis. Methods: HAoSMCs were cultured
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Association of Cancer Antigen 125 with Long-Term Prognosis in Light-Chain Cardiorenal Amyloidosis Cardiorenal Med. (IF 3.8) Pub Date : 2022-10-10
Introduction: Light-chain (AL) cardiorenal amyloidosis has been characterized as type 5 cardiorenal syndrome with fluid overload and poor prognosis. Cancer antigen 125 (CA125) has the potential for its use in evaluating fluid load and prognosis for heart failure. However, less details for CA125 in AL cardiorenal amyloidosis have been reported. Methods: Sixty patients diagnosed with AL cardiorenal amyloidosis
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Fluid Overload and Precision Net Ultrafiltration in Critically Ill Patients Cardiorenal Med. (IF 3.8) Pub Date : 2022-10-06 Raghavan Murugan, Amir Kazory, Luca Sgarabotto, Claudio Ronco
Background: Fluid overload is present in two-thirds of critically ill patients with acute kidney injury and is associated with morbidity, mortality, and increased healthcare resource utilization. Kidney replacement therapy is frequently used for net fluid removal (i.e., net ultrafiltration) in patients with severe oliguric acute kidney injury. However, ultrafiltration has considerable risks associated
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Fluid Overload and Precision Net Ultrafiltration in Critically Ill Patients Cardiorenal Med. (IF 3.8) Pub Date : 2022-10-06
Background: Fluid overload is present in two-thirds of critically ill patients with acute kidney injury and is associated with morbidity, mortality, and increased healthcare resource utilization. Kidney replacement therapy (KRT) is frequently used for net fluid removal (i.e., net ultrafiltration [UFNET]) in patients with severe oliguric acute kidney injury. However, ultrafiltration has considerable
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Diagnosis of Fluid Overload: from Conventional to Contemporary Concepts Cardiorenal Med. (IF 3.8) Pub Date : 2022-09-12 Abhilash Koratala, Claudio Ronco, Amir Kazory
Fluid overload has been associated with morbidity and mortality in various clinical scenarios including heart failure and critical illness. It exerts pathologic sequelae in almost all the organ systems. Proper management of patients with fluid overload requires knowledge of the underlying pathophysiology, objective evaluation of volume status, selection of appropriate therapeutic options, and maintenance
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Diagnosis of Fluid Overload: From Conventional to Contemporary Concepts Cardiorenal Med. (IF 3.8) Pub Date : 2022-09-12
Fluid overload has been associated with morbidity and mortality in various clinical scenarios including heart failure and critical illness. It exerts pathologic sequelae in almost all the organ systems. Proper management of patients with fluid overload requires knowledge of the underlying pathophysiology, objective evaluation of volume status, selection of appropriate therapeutic options, and maintenance
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Experience of a bespoke hyperkalaemia clinic to facilitate prescribing of renin-angiotensin-aldosterone system inhibitors in patients with heart failure with reduced ejection fraction Cardiorenal Med. (IF 3.8) Pub Date : 2022-08-31 Ibrahim Ali, Darren Green, Paul Kalra, Philip A. Kalra
Background Renin-angiotensin-aldosterone system inhibitors (RAASi) improve prognosis in patients with heart failure with reduced ejection fraction (HFrEF), but suboptimal dosing or discontinuation of these medications often occurs due to RAASi-associated hyperkalaemia. We established a nephrology-led hyperkalaemia clinic to oversee prescribing of patiromer, an oral potassium-binder, to facilitate RAASi
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Interaction between hyperuricemia and admission lactate increases the risk of acute kidney injury in patients with ST-segment elevation myocardial infarction Cardiorenal Med. (IF 3.8) Pub Date : 2022-08-02 Yanlei He, Dingzhou Wang, Xi Zhou, Qianli Zhu, Qingcheng Lin, Xia Hong, Weijian Huang, Peiren Shan, Dongjie Liang
Abstract Background and Objective: Acute kidney injury (AKI) is a common complication associated with adverse outcomes among patients with ST-segment elevation myocardial infarction (STEMI). This is conflicting information about the relationship between hyperuricemia and AKI in STEMI. This work aims to investigate the effect of the interaction between hyperuricemia and lactate on the risk of AKI. Methods:
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Roles for SGLT2 Inhibitors in Cardiorenal Disease Cardiorenal Med. (IF 3.8) Pub Date : 2022-07-14 Jennifer B. Green, Peter A. McCullough
Cardiovascular disease (CVD) and chronic kidney disease (CKD) share common risk factors, including type 2 diabetes mellitus (T2DM). In cardiovascular outcome studies of patients with T2DM, sodium-glucose cotransporter 2 inhibitor (SGLT2i) therapy was associated with risk reductions in cardiorenal endpoints. This article aims to provide a comprehensive overview of the efficacy of SGLT2i therapy in patients
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Catheter ablation for atrial fibrillation in patients with chronic kidney disease and on dialysis – a meta-analysis and review Cardiorenal Med. (IF 3.8) Pub Date : 2022-07-12 Isaac Chung, Yasir Khan, Hilary Warrens, Rao Kondapally Seshasai, Manav Sohal, Debasish Banerjee
Background: Atrial fibrillation (AF) is common in chronic kidney disease (CKD) patients and is difficult to treat with antiarrhythmics and anticoagulants due to abnormal metabolism and increased side effects. Catheter ablation, if successful, may be a safer alternative. This review aims to analyse the effect of CKD or haemodialysis (HD) on recurrence of AF after catheter ablation . This review evaluates