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Sweetened Beverages, Genetic Susceptibility, and Incident Atrial Fibrillation: A Prospective Cohort Study Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2024-03-05 Ying Sun, Bowei Yu, Yuefeng Yu, Bin Wang, Xiao Tan, Yingli Lu, Yu Wang, Kun Zhang, Ningjian Wang
BACKGROUND:An association between sweetened beverages and several cardiometabolic diseases has been reported, but their association with atrial fibrillation (AF) is unclear. We aimed to investigate the associations between consumption of sugar-sweetened beverages (SSB), artificially sweetened beverages (ASB), and pure fruit juice (PJ) and risk of consumption with AF risk and further evaluate whether
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Genetic Testing in Brugada Syndrome: A 30-Year Experience Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2024-03-01 Luigi Pannone, Antonio Bisignani, Randy Osei, Anaïs Gauthey, Antonio Sorgente, Cinzia Monaco, Domenico Giovanni Della Rocca, Alvise Del Monte, Antanas Strazdas, Joerelle Mojica, Maysam Al Housari, Vincenzo Miraglia, Sahar Mouram, Giampaolo Vetta, Gaetano Paparella, Robbert Ramak, Ingrid Overeinder, Gezim Bala, Alexandre Almorad, Erwin Ströker, Gudrun Pappaert, Juan Sieira, Thomy de Ravel, Mark La Meir
BACKGROUND:A pathogenic/likely pathogenic variant can be found in 20% to 25% of patients with Brugada syndrome (BrS) and a pathogenic/likely pathogenic variant in SCN5A is associated with a worse prognosis. The aim of this study is to define the diagnostic yield of a large gene panel with ACMG variant classification and to assess prognosis of SCN5A and non-SCN5A variants.METHODS:All patients with BrS
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HRAS-Mutant Cardiomyocyte Model of Multifocal Atrial Tachycardia Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2024-02-28 Nelson A. Rodríguez, Nihir Patel, Rafael Dariolli, Simon Ng, Angelika G. Aleman, Jingqi Q.X. Gong, Hung-Mo Lin, Matthew Rodríguez, Rebecca Josowitz, Katia Sol-Church, Karen W. Gripp, Xianming Lin, Soomin C. Song, Glenn I. Fishman, Eric A. Sobie, Bruce D. Gelb
BACKGROUND:Germline HRAS gain-of-function pathogenic variants cause Costello syndrome (CS). During early childhood, 50% of patients develop multifocal atrial tachycardia, a treatment-resistant tachyarrhythmia of unknown pathogenesis. This study investigated how overactive HRAS activity triggers arrhythmogenesis in atrial-like cardiomyocytes (ACMs) derived from human-induced pluripotent stem cells bearing
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Differential Pacing Maneuver From the Vein of Marshall Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2024-02-23 Naohiko Kawaguchi, Yasuaki Tanaka, Kenji Okubo, Shinichi Tachibana, Emiko Nakashima, Katsumasa Takagi, Hiroyuki Hikita, Tetsuo Sasano, Atsushi Takahashi
BACKGROUND:Bidirectional mitral isthmus (MI) block is conventionally verified by differential pacing from the coronary sinus (CS) and its sequence change. This study aimed to evaluating the ability of differential pacing from the vein of Marshall (VOM) to detect epicardial MI connections.METHODS:Radiofrequency and VOM ethanol MI ablation were performed with a VOM electrode catheter inserted to the
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Development of the NOCSAE Standard to Reduce the Risk of Commotio Cordis Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2024-02-23 Nathan Dau, Cynthia Bir, Elizabeth McCalley, David Halstead, Mark S. Link
BACKGROUND:Commotio cordis, sudden cardiac death (SCD) caused by relatively innocent impact to the chest, is one of the leading causes of SCD in sports. Commercial chest protectors have not been demonstrated to mitigate the risk of these SCDs.METHODS:To develop a standard to assess chest protectors, 4 phases occurred. A physiological commotio cordis model was utilized to assess variables that predicted
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Predicting Major Adverse Events in Patients Undergoing Transcatheter Left Atrial Appendage Occlusion Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2024-02-23 Kamil F. Faridi, Emily L. Ong, Sarah Zimmerman, Paul D. Varosy, Daniel J. Friedman, Jonathan C. Hsu, Fred Kusumoto, Bobak J. Mortazavi, Karl E. Minges, Lucy Pereira, Dhanunjaya Lakkireddy, Christina Koutras, Beth Denton, Julie Mobayed, Jeptha P. Curtis, James V. Freeman
BACKGROUND:The National Cardiovascular Data Registry and Left Atrial Appendage Occlusion (LAAO) registry includes the vast majority of transcatheter LAAO procedures performed in the United States. The objective of this study was to develop a model predicting adverse events among patients undergoing LAAO with Watchman FLX.METHODS:Data from 41 001 LAAO procedures with Watchman FLX from July 2020 to September
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Pulsed Field Ablation Index–Guided Ablation for Lesion Formation: Impact of Contact Force and Number of Applications in the Ventricular Model Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2024-02-23 Luigi Di Biase, Jacopo Marazzato, Assaf Govari, Andreas Altman, Christopher Beeckler, Joseph Keyes, Tushar Sharma, Vito Grupposo, Fengwei Zou, Masafumi Sugawara, Atsushi Ikeda, Farshad Raissi, Rahul Bhardwaj, Jonathan C. Hsu, Mark Lee, Rajesh Banker, Sanghamitra Mohanty, Andrea Natale, Qi Chen, Paras Parikh, Xiao-Dong Zhang, Hiroshi Nakagawa
BACKGROUND:The effect of contact force (CF) on lesion formation is not clear during pulsed field ablation (PFA). The aim of this study was to evaluate the impact of CF, PFA, and their interplay through the PFA index (PF index) formula on the ventricular lesion size in swine.METHODS:PFA was delivered through the CF-sensing OMNYPULSE catheter. Predefined PFA applications (×3, ×6, ×9, and ×12) were delivered
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Spatially Conserved Spiral Wave Activity During Human Atrial Fibrillation Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2024-02-13 Wouter-Jan Rappel, Tina Baykaner, Junaid Zaman, Prasanth Ganesan, Albert J. Rogers, Sanjiv M. Narayan
BACKGROUND:Atrial fibrillation is the most common cardiac arrhythmia in the world and increases the risk for stroke and morbidity. During atrial fibrillation, the electric activation fronts are no longer coherently propagating through the tissue and, instead, show rotational activity, consistent with spiral wave activation, focal activity, collision, or partial versions of these spatial patterns. An
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Utilizing Human-Induced Pluripotent Stem Cells to Study Cardiac Electroporation Pulsed-Field Ablation Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2024-02-12 Leonid Maizels, Eyal Heller, Michal Landesberg, Shany Glatstein, Irit Huber, Gil Arbel, Amira Gepstein, Doron Aronson, Shirley Sharabi, Roy Beinart, Amit Segev, Elad Maor, Lior Gepstein
BACKGROUND:Electroporation is a promising nonthermal ablation method for cardiac arrhythmia treatment. Although initial clinical studies found electroporation pulsed-field ablation (PFA) both safe and efficacious, there are significant knowledge gaps concerning the mechanistic nature and electrophysiological consequences of cardiomyocyte electroporation, contributed by the paucity of suitable human
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Cardiac Pulsed Field Ablation Lesion Durability Assessed by Polarization-Sensitive Optical Coherence Reflectometry Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2024-02-06 Maria Terricabras, Raphael P. Martins, Rafael Peinado, Pawel Derejko, Lluis Mont, Sabine Ernst, David Herranz, Christophe Bailleul, Atul Verma
BACKGROUND:Pulsed field ablation uses electrical fields to cause nonthermal cell death over several hours. Polarization-sensitive optical coherence reflectometry is an optical imaging technique that can detect changes in the tissue ultrastructure in real time, which occurs when muscular tissue is damaged. The objective of this study was to evaluate the ability of a polarization-sensitive optical coherence
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Incidence and Outcomes of New-Onset Right Bundle Branch Block Following Transcatheter Aortic Valve Replacement Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2024-01-30 Nicholas Y. Tan, Demilade Adedinsewo, Abdallah El Sabbagh, Ahmed F. Sayed Ahmed, Andrea Carolina Morales-Lara, Mikolaj Wieczorek, Malini Madhavan, Siva K. Mulpuru, Abhishek J. Deshmukh, Samuel J. Asirvatham, Mackram F. Eleid, Paul A. Friedman, Yong-Mei Cha, Ammar M. Killu
BACKGROUND:The incidence and prognosis of right bundle branch block (RBBB) following transcatheter aortic valve replacement (TAVR) are unknown. Hence, we sought to characterize the incidence of post-TAVR RBBB and determine associated risks of permanent pacemaker (PPM) implantation and mortality.METHODS:All patients 18 years and above without preexisting RBBB or PPM who underwent TAVR at US Mayo Clinic
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Artificial Intelligence Model Predicts Sudden Cardiac Arrest Manifesting With Pulseless Electric Activity Versus Ventricular Fibrillation Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2024-01-29 Lauri Holmstrom, Bryan Bednarski, Harpriya Chugh, Habiba Aziz, Hoang Nhat Pham, Arayik Sargsyan, Audrey Uy-Evanado, Damini Dey, Angelo Salvucci, Jonathan Jui, Kyndaron Reinier, Piotr J. Slomka, Sumeet S. Chugh
BACKGROUND:There is no specific treatment for sudden cardiac arrest (SCA) manifesting as pulseless electric activity (PEA) and survival rates are low; unlike ventricular fibrillation (VF), which is treatable by defibrillation. Development of novel treatments requires fundamental clinical studies, but access to the true initial rhythm has been a limiting factor.METHODS:Using demographics and detailed
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Conduction System Stimulation to Avoid Left Ventricle Dysfunction Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2024-01-29 Carlos E. González-Matos, Oriol Rodríguez-Queralto, Fátima Záraket, Jesús Jiménez, Benjamín Casteigt, Ermengol Vallès
BACKGROUND:Right ventricular apical pacing (RVAP) can produce left ventricle dysfunction. Conduction system pacing (CSP) has been used successfully to reverse left ventricle dysfunction in patients with left bundle branch block. To date, data about CSP prevention of left ventricle dysfunction in patients with preserved left ventricular ejection fraction (LVEF) are scarce and limited mostly to nonrandomized
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Long-Term Durability of High- and Very High-Power Short-Duration PVI by Invasive Remapping: The HPSD Remap Study Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2024-01-29 Nándor Szegedi, Zoltán Salló, Vivien Klaudia Nagy, István Osztheimer, István Hizoh, Bálint Lakatos, Melinda Boussoussou, Gábor Orbán, Márton Boga, Arnold Béla Ferencz, Ferenc Komlósi, Patrik Tóth, Péter Perge, Attila Kovács, Béla Merkely, László Gellér
BACKGROUND:High-power short-duration ablation has shown impressive efficacy and safety for pulmonary vein isolation (PVI); however, initial efficacy results with very high power short-duration ablation were discouraging. This study compared the long-term durability of PVI performed with a 90- versus 50-W power setting.METHODS:Patients were randomized 1:1 to undergo PVI with the QDOT catheter using
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Unraveling Complexities in Genetically Elusive Long QT Syndrome Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2024-01-24 Babken Asatryan, Brittney Murray, Alessio Gasperetti, Rebecca McClellan, Andreas S. Barth
Genetic testing has become standard of care for patients with long QT syndrome (LQTS), providing diagnostic, prognostic, and therapeutic information for both probands and their family members. However, up to a quarter of patients with LQTS do not have identifiable Mendelian pathogenic variants in the currently known LQTS-associated genes. This absence of genetic confirmation, intriguingly, does not
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Blister Score: A Novel, Externally Validated Tool for Predicting Cardiac Implantable Electronic Device Infections, and Its Cost-Utility Implications for Antimicrobial Envelope Use Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2024-01-22 Edd Maclean, Karishma Mahtani, Shohreh Honarbakhsh, Charles Butcher, Nikhil Ahluwalia, Adam S.C. Dennis, Antonio Creta, Malcolm Finlay, Mark Elliott, Vishal Mehta, Nadeev Wijesuriya, Omar Shaikh, Yom Zaw, Chizute Ogbedeh, Vasu Gautam, Pier D. Lambiase, Richard J. Schilling, Mark J. Earley, Philip Moore, Amal Muthumala, Simon E.C. Sporton, Ross J. Hunter, Christopher A. Rinaldi, Jonathan Behar, Claire
BACKGROUND:Antimicrobial envelopes reduce the incidence of cardiac implantable electronic device infections, but their cost restricts routine use in the United Kingdom. Risk scoring could help to identify which patients would most benefit from this technology.METHODS:A novel risk score (BLISTER) was derived from multivariate analysis of factors associated with cardiac implantable electronic device
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Genetic Atrial Cardiomyopathies: Common Features, Specific Differences, and Broader Relevance to Understanding Atrial Cardiomyopathy. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-11-29 Edouard Marcoux,Deanna Sosnowski,Sandro Ninni,Martin Mackasey,Julia Cadrin-Tourigny,Jason D Roberts,Morten Salling Olesen,Diane Fatkin,Stanley Nattel
Atrial cardiomyopathy is a condition that causes electrical and contractile dysfunction of the atria, often along with structural and functional changes. Atrial cardiomyopathy most commonly occurs in conjunction with ventricular dysfunction, in which case it is difficult to discern the atrial features that are secondary to ventricular dysfunction from those that arise as a result of primary atrial
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Risk Factors for the Development of New-Onset Persistent Atrial Fibrillation: Subanalysis of the VITAL Study. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-11-29 Melissa E Middeldorp,Roopinder K Sandhu,Jessica Mao,Baris Gencer,Jacqueline S Danik,Vinayaga Moorthy,Nancy R Cook,Christine M Albert
BACKGROUND Sustained forms of atrial fibrillation (AF) are associated with lower treatment success rates and poorer prognosis compared with paroxysmal AF. Yet, little is known about risk factors that predispose to persistent AF on initial presentation. Our objective was to define risk factors associated with new-onset persistent AF. METHODS We prospectively examined the differential associations between
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Point-by-Point Pulsed Field Ablation Using a Multimodality Generator and a Contact Force-Sensing Ablation Catheter: Comparison With Radiofrequency Ablation in a Remapped Chronic Swine Heart. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-11-23 Luigi Di Biase,Jacopo Marazzato,Fengwei Zou,Aung Lin,Vito Grupposo,Nilarun Chowdhuri,Jennifer Maffre,Salman Farshchi-Heydari,Tushar Sharma,Christopher Beeckler,Assaf Govari,Rahul Bhardwaj,Sanghamitra Mohanty,Andrea Natale,Hiroshi Nakagawa,Xiaodong Zhang
BACKGROUND Pulsed field ablation (PFA) has emerged as an alternative to radiofrequency ablation. However, data on focal point-by-point PFA are scarce. The aim of this study was to compare lesion durability and collateral damage between focally delivered unipolar/biphasic PFA versus radiofrequency in swine. METHODS Eighteen swine were randomized to low-dose PFA, high-dose PFA, and radiofrequency using
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Effects of Intraluminal Content on Esophageal Lesion Formation During Radiofrequency Catheter Ablation: Preliminary Data. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-11-16 Fabrizio R Assis,Harikrishna Tandri,Rushil Shah,Christopher Batich,Parag Karmarkar,Akhilesh Gonuguntla,Michele Dill,Ekin C Uzunoglu,John Nicholas Catanzaro
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A Multicenter, Phase 2, Randomized, Controlled Study of the Efficacy and Safety of Etripamil Nasal Spray for the Acute Reduction of Rapid Ventricular Rate in Patients with Symptomatic Atrial Fibrillation (ReVeRA-201). Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-11-11 A John Camm,Jonathan P Piccini,Marco Alings,Paul Dorian,Gilbert Gosselin,Marie-Claude Guertin,James E Ip,Peter R Kowey,Blandine Mondésert,Fransisco J Prins,Jean-Francois Roux,Bruce S Stambler,J W Martijn van Eck,Nadea Al Windy,Nathalie Thermil,Silvia Shardonofsky,David B Bharucha,Denis Roy
Background: Despite chronic therapies, atrial fibrillation (AF) leads to rapid ventricular rates (RVR) often requiring intravenous treatments. Etripamil is a fast-acting, calcium-channel blocker administered intranasally affecting the atrioventricular-node within minutes. Methods: ReVeRA evaluated efficacy and safety of etripamil for the reduction of ventricular rate (VR) in patients presenting urgently
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Natriuretic Peptide Receptor B Protects Against Atrial Fibrillation by Controlling Atrial cAMP Via Phosphodiesterase 2. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-11-07 Tristan W Dorey,Yingjie Liu,Hailey J Jansen,Loryn J Bohne,Martin Mackasey,Logan Atkinson,Shuvam Prasai,Darrell D Belke,Ali Fatehi-Hassanabad,Paul W M Fedak,Robert A Rose
BACKGROUND β-AR (β-adrenergic receptor) stimulation regulates atrial electrophysiology and Ca2+ homeostasis via cAMP-dependent mechanisms; however, enhanced β-AR signaling can promote atrial fibrillation (AF). CNP (C-type natriuretic peptide) can also regulate atrial electrophysiology through the activation of NPR-B (natriuretic peptide receptor B) and cGMP-dependent signaling. Nevertheless, the role
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No Effect of Continued Antiarrhythmic Drug Treatment on Top of Optimized Pulmonary Vein Isolation in Patients With Persistent Atrial Fibrillation: Results From the POWDER-AF2 Trial. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-11-03 Anthony Demolder,Louisa O'Neill,Milad El Haddad,Daniel Scherr,Johan Vijgen,Michael Wolf,Benjamin Berte,Felipe Bisbal,Arne Johannessen,Maximo Rivero-Ayerza,Tom De Potter,Benjamin De Becker,Jean-Benoît le Polain de Waroux,Sebastien Knecht,Rene Tavernier,Mattias Duytschaever
BACKGROUND In patients with persistent atrial fibrillation (PersAF), catheter ablation aiming for pulmonary vein isolation (PVI) is associated with moderate clinical effectiveness. We investigated the benefit of continuing previously ineffective class 1C or 3 antiarrhythmic drug therapy (ADT) in the setting of a standardized PVI-only ablation strategy. METHODS In this multicenter, randomized controlled
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Nanosecond Pulsed Electric Field Ablation With a Bipolar Clamp Creates Durable Transmural Lesions in Cardiac Tissue. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-11-03 Federica Serra,Jonathan M Philpott,Johanna U Neuber,Emily Shih,James C Etheridge,Frency Varghese,Gregory D Rushing,Christian W Zemlin
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Ventricular Preexcitation in Hypertrophic Cardiomyopathy: Dove or a Hawk? Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-11-03 Henry Chubb,Anne M Dubin
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Hypertrophic Cardiomyopathy and Ventricular Preexcitation in the Young: Cause and Accessory Pathway Characteristics. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-10-25 Robert Przybylski,Sakethram Saravu Vijayashankar,Edward T O'Leary,Robyn J Hylind,Jennifer Noon,Audrey Dionne,Elizabeth S DeWitt,Vassilios J Bezzerides,Dominic J Abrams
BACKGROUND The cause of hypertrophic cardiomyopathy (HCM) in the young is highly varied. Ventricular preexcitation (preexcitation) is well recognized, yet little is known about the specificity for any cause and the characteristics of the responsible accessory pathways (AP). METHODS Retrospective cohort study of patients <21 years of age with HCM/preexcitation from 2000 to 2022. The cause of HCM was
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Retrieval of Chronically Implanted Dual-chamber Leadless Pacemakers in an Ovine Model. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-09-28 Rajesh S Banker,Marian K Rippy,Nicole Cooper,Petr Neužil,Derek V Exner,Devi G Nair,Daniel F Booth,David Ligon,Nima Badie,Mark Krans,Kenji Ando,Reinoud E Knops,James E Ip,Rahul N Doshi,Mayer Rashtian,Vivek Y Reddy
BACKGROUND The clinical utilization of leadless pacemakers (LPs) as an alternative to traditional transvenous pacemakers is likely to increase with the advent of dual-chamber LP systems. Since device retrieval to allow LP upgrade or replacement will become an important capability, the first such dual-chamber, helix-fixation LP system (Aveir DR; Abbott, Abbott Park, IL) was specifically designed to
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Implantable Cardioverter-defibrillator Deactivation at Distance for the Dignity of Dying (the 4D Project). Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-09-27 Bryce Alexander,Melanie Foisy,Tereza Florica,Sanoj Chacko,Hoshiar Abdollah,Victor Neira,Andres Enriquez,Annie Hung,Damian P Redfearn,Christopher S Simpson,Adrian Baranchuk
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Comparison of Ablation Strategies for Persistent Atrial Fibrillation: A Post Hoc Analysis of the DECAAF II Study. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-09-26 Charbel Noujaim,Botao Shan,Jitae A Kim,Mario Mekhael,Han Feng,Ala Assaf,Hadi Younes,Nour Chouman,Chanho Lim,Tarek Ayyoub,Chao Huang,Nassir F Marrouche,Mihail G Chelu
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Abnormal Atrial Potentials Recorded During Sinus Rhythm or Pacing Represent Substrates for Reentrant Atrial Tachycardia. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-09-20 Yosuke Nakatani,F Daniel Ramirez,Masateru Takigawa,Takashi Nakashima,Clémentine André,Cyril Goujeau,Philipp Krisai,Takamitsu Takagi,Tsukasa Kamakura,Konstantinos Vlachos,Aline Carapezzi,Ghassen Cheniti,Romain Tixier,Nicolas Welte,Remi Chauvel,Josselin Duchateau,Thomas Pambrun,Nicolas Derval,Frédéric Sacher,Meleze Hocini,Michel Haïssaguerre,Pierre Jaïs
BACKGROUND Abnormal atrial potentials (AAPs) recorded during sinus rhythm/atrial pacing may indicate areas of slow conduction capable of supporting reentrant atrial tachycardia (AT). Therefore, we sought to examine the relationship between AAPs and AT circuits. METHODS One hundred twenty-three reentrant ATs in 104 patients were analyzed. AAPs, consisting of fragmented potentials and split potentials
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Reversible Pulsed Electrical Fields as an In Vivo Tool to Study Cardiac Electrophysiology: The Advent of Pulsed Field Mapping. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-09-20 Jacob S Koruth,Petr Neuzil,Iwanari Kawamura,Kenji Kuroki,Jan Petru,Gediminas Rackauskas,Moritoshi Funasako,Audrius Aidietis,Vivek Y Reddy
BACKGROUND During electrophysiological mapping of tachycardias, putative target sites are often only truly confirmed to be vital after observing the effect of ablation. This lack of mapping specificity potentiates inadvertent ablation of innocent cardiac tissue not relevant to the arrhythmia. But if myocardial excitability could be transiently suppressed at critical regions, their suitability as targets
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Hypoxia Promotes Atrial Tachyarrhythmias via Opening of ATP-Sensitive Potassium Channels. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-08-30 Mark J Specterman,Qadeer Aziz,Yiwen Li,Naomi A Anderson,Leona Ojake,Keat-Eng Ng,Alison M Thomas,Malcolm C Finlay,Richard J Schilling,Pier D Lambiase,Andrew Tinker
BACKGROUND Hypoxia-ischemia predisposes to atrial arrhythmia. Atrial ATP-sensitive potassium channel (KATP) modulation during hypoxia has not been explored. We investigated the effects of hypoxia on atrial electrophysiology in mice with global deletion of KATP pore-forming subunits. METHODS Whole heart KATP RNA expression was probed. Whole-cell KATP current and action potentials were recorded in isolated
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Predicting Lesion Durability With PFA: One Step Closer. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-08-30 Jacob S Koruth,Iwanari Kawamura
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Nonthermal Point-by-Point Pulmonary Vein Isolation Using a Novel Pulsed Field Ablation System. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-08-28 Jan-Per Wenzel,Marc D Lemoine,Laura Rottner,Ilaria My,Fabian Moser,Julius Obergassel,Moritz Nies,Jan Rieß,Djemail Ismaili,Julius Nikorowitsch,Feifan Ouyang,Paulus Kirchhof,Andreas Rillig,Andreas Metzner,Bruno Reissmann
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Payer-Negotiated Prices for Cardiac Electrophysiology Procedures at 2022-2023 Top 100 US News & World Report for Cardiology and Heart Surgery Hospitals. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-08-25 Kunal Gupta,Ravi Gupta,Roy Xiao,Vinay K Rathi,P Elliott Miller,Joseph S Ross,Sanket S Dhruva
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Temporal Trends and Lesion Sets for Persistent Atrial Fibrillation Ablation: A Meta-Analysis With Trial Sequential Analysis and Meta-Regression. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-08-17 Arunashis Sau,Sharan Kapadia,Sayed Al-Aidarous,James Howard,Afzal Sohaib,Markus B Sikkel,Ahran Arnold,Jonathan W Waks,Daniel B Kramer,Nicholas S Peters,Fu Siong Ng
BACKGROUND Ablation for persistent atrial fibrillation (PsAF) has been performed for over 20 years, although success rates have remained modest. Several adjunctive lesion sets have been studied but none have become standard of practice. We sought to describe how the efficacy of ablation for PsAF has evolved in this time period with a focus on the effect of adjunctive ablation strategies. METHODS Databases
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Sex and Gene Influence Arrhythmia Susceptibility in Murine Models of Calmodulinopathy. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-08-17 Lisa M Wren,Jean-Marc DeKeyser,David Y Barefield,Nicole A Hawkins,Elizabeth M McNally,Jennifer A Kearney,J Andrew Wasserstrom,Alfred L George
BACKGROUND Pathogenic variants in genes encoding CaM (calmodulin) are associated with a life-threatening ventricular arrhythmia syndrome (calmodulinopathy). The in vivo consequences of CaM variants have not been studied extensively and there is incomplete understanding of the genotype-phenotype relationship for recurrent variants. We investigated effects of different factors on calmodulinopathy phenotypes
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Correction to: Orthostatic Hypotension: Management of a Complex, But Common, Medical Problem. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-08-15
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Electrical Resynchronization and Clinical Outcomes During Long-Term Follow-Up in Intraventricular Conduction Delay Patients Applied Left Bundle Branch Pacing-Optimized Cardiac Resynchronization Therapy. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-08-14 Xueying Chen,Xiao Li,Yingnan Bai,Jingfeng Wang,Shengmei Qin,Jin Bai,Wei Wang,Yixiu Liang,Haiyan Chen,Yangang Su,Junbo Ge
BACKGROUND Left bundle branch-optimized cardiac resynchronization therapy (LOT-CRT) has shown encouraging results for QRS duration reduction and heart function improvement. However, the feasibility and efficacy of LOT-CRT have not been well established in intraventricular conduction delay patients. This study aims to assess and compare the efficacy and clinical outcome of CRT based on left bundle branch
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Dynamics of High-Density Unipolar Epicardial Electrograms During PFA. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-08-14 Gerard Amorós-Figueras,Sergi Casabella-Ramon,Zoraida Moreno-Weidmann,Antoni Ivorra,Jose M Guerra,Tomás García-Sánchez
BACKGROUND Pulsed field ablation (PFA) is a novel nonthermal cardiac ablation technology based on irreversible electroporation (IRE). While areas of IRE lead to durable lesions, the surrounding regions, where reversible electroporation occurs, recover. The behavior of local electrograms in areas of different electroporation levels remains unknown. The goal of this study is to characterize electrogram
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Myocarditis and Sudden Cardiac Death in the Community: Clinical and Pathological Insights From a National Registry in the United Kingdom. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-08-11 Raghav T Bhatia,Gherardo Finocchiaro,Joseph Westaby,Nikhil Chatrath,Elijah R Behr,Michael Papadakis,Sanjay Sharma,Mary N Sheppard
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Catheter Ablation of Atrial Fibrillation in Adult Congenital Heart Disease: Procedural Characteristics and Outcomes. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-07-24 Tiffany Y Hu,Chaitra Janga,Mustapha Amin,Nicholas Y Tan,David O Hodge,Ramila A Mehta,Christopher J McLeod,Anca Chiriac,William R Miranda,Heidi M Connolly,Samuel J Asirvatham,Abhishek J Deshmukh,Alexander C Egbe,Malini Madhavan
BACKGROUND The outcomes of catheter ablation for atrial fibrillation in adults with congenital heart disease are not well described. METHODS In a retrospective study of adult patients with congenital heart disease who underwent catheter ablation for atrial fibrillation between 2000 and 2020 at Mayo Clinic, procedural characteristics and outcomes were collected. The primary outcomes were atrial arrhythmia
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Dronedarone Versus Sotalol in Antiarrhythmic Drug-Naive Veterans With Atrial Fibrillation. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-07-24 Krishna Pundi,Jun Fan,Shaum Kabadi,Natasha Din,Carina Blomström-Lundqvist,A John Camm,Peter Kowey,Jagmeet P Singh,Jason Rashkin,Mattias Wieloch,Mintu P Turakhia,Alexander T Sandhu
BACKGROUND Sotalol and dronedarone are both used for maintenance of sinus rhythm for patients with atrial fibrillation. However, while sotalol requires initial monitoring for QT prolongation and proarrhythmia, dronedarone does not. These treatments can be used in comparable patients, but their safety and effectiveness have not been compared head to head. Therefore, we retrospectively evaluated the
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Ventricular Electrograms Duration Map to Detect Ventricular Arrhythmia Substrate: the VEDUM Project Study. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-07-24 Pietro Rossi,Filippo Maria Cauti,Marta Niscola,Michele Magnocavallo,Marco Polselli,Silvia Capone,Domenico Giovanni Della Rocca,Jorge Rodriguez-Garrido,Gianfranco Piccirillo,Ignasi Anguera,Paolo Dallaglio,Stefano Bianchi
BACKGROUND The analysis of the wave-front activation patterns is crucial for the comprehension and treatment of ventricular tachycardia (VT). The ventricular electrograms duration map (VEDUM) is a potential method to identify areas (VEDUM area) with slow and inhomogeneous activation. There is no available data on the characteristics and the arrhythmogenic role of VEDUM areas identified during sinus/paced
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Impact of Median Sternotomy on Safety and Efficacy of the Subcutaneous Implantable Cardioverter Defibrillator. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-07-24 Alan Sugrue,Rand Ibrahim,Marvin Lu,Neal K Bhatia,Laith Alkukhun,Joseph Adewumi,Robert D Schaller,Francis E Marchlinski,Benjamin D'Souza,Babak Nazer,Wendy Tzou,Faisal M Merchant,David S Frankel
BACKGROUND Subcutaneous implantable cardioverter defibrillators (S-ICDs) are an attractive alternative to transvenous ICDs among those not requiring pacing. However, the risks of damage to the S-ICD electrode during sternotomy and adverse interactions with sternal wires remain unclear. We sought to determine the rates of damage to the S-ICD lead during sternotomy, inappropriate shocks from electrical
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Novel Intercostal Extravascular ICD Lead Compatible With Standard Pulse Generators: Another Step Forward in ICD Evolution? Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-07-24 Edoardo Bressi,Kenneth A Ellenbogen,Jordana Kron
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Impact of Diastolic Dysfunction on the Risk of Sudden Cardiac Arrest. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-07-24 Samir Saba,Suresh Mulukutla,Floyd Thoma,Konstantinos N Aronis,Aditya Bhonsale,Krishna Kancharla,Andrew Voigt,Alaa A Shalaby,N A Mark Estes,Sandeep Jain
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Physiologic Effects of Right-Sided Intravascular Cervical Sympathetic Nerve Stimulation. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-06-26 Timothy M Markman,Francis E Marchlinski,Andrew E Epstein,Saman Nazarian
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Microvasular Dysfunction and Reduced Cardiac Stress Reactivity in Postural Orthostatic Tachycardia Associated With Postacute COVID-19. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-06-19 Ali Mahdi,Klara Lodin,Ulrika Reistam,Artur Fedorowski,Malin Nygren-Bonnier,Michael Runold,Judith Bruchfeld,Liyew Desta,John Pernow,Jannike Nickander,Marcus Ståhlberg
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Evaluating Recommendations About Atrial Fibrillation for Patients and Clinicians Obtained From Chat-Based Artificial Intelligence Algorithms. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-06-19 Zahra Azizi,Pouria Alipour,Sofia Gomez,Cassandra Broadwin,Sumaiya Islam,Ashish Sarraju,A J Rogers,Alexander T Sandhu,Fatima Rodriguez
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Action Potential Morphology Accurately Predicts Proarrhythmic Risk for Drugs With Potential to Prolong Cardiac Repolarization. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-06-19 William Lee,Ben Ng,Melissa M Mangala,Matthew D Perry,Rajesh N Subbiah,Jamie I Vandenberg,Adam P Hill
BACKGROUND Drug-induced or acquired long QT syndrome occurs as a result of the unintended disruption of cardiac repolarization due to drugs that block cardiac ion channels. These side effects have been responsible for the withdrawal of a range of drugs from market and are a common reason for termination of the development of new drugs in the preclinical stage. Existing approaches to risk prediction
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Real-World Performance of Conduction System Pacing Compared With Traditional Pacing. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-06-19 Jordana Kron,Matthew Bernabei,Daniel Kaiser,Sudip Nanda,Faiz Ali Subzposh,Patrick Zimmerman,Rachael Rose,Kiah Butler,Kenneth A Ellenbogen
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Efficacy and Safety of Adjunctive and Primary Use of the TightRail Mechanical Cutting Sheath for Lead Extraction. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-06-02 James R Sampognaro,Maham Karatela,Robert K Lewis,Eric Black-Maier,Sean D Pokorney,Donald D Hegland,Jonathan P Piccini
BACKGROUND Rotational cutting tools are increasingly used in transvenous lead extraction. There are limited data on their safety and efficacy, particularly when used adjunctively for stalled progression. The aim of this study was to evaluate the utilization, safety, and effectiveness of mechanical rotational cutting tools for transvenous lead extraction. METHODS Patients undergoing transvenous lead
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Tetralogy of Fallot: A Long Journey but Getting Closer to Perfection. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-05-31 Benjamin H Hammond,Susan P Etheridge,Elizabeth Vickers Saarel
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Impact of CIED Field Advisories: Unreimbursed Costs to Medical Systems. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-05-31 William Mai,Linda Schwartz,Christine Kneeland,Tamara Meyers-Laplace,Denise Brusa,Megan Davis,James Ryan,Christine Nelson,Vaibhov Vaidya,Dan Sorajja,Kevin Cragun,Freddy Del Carpio Munoz,Yong-Mei Cha,Nikita Jhawar,Fred Kusumoto
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Procedural Trends in Catheter Ablation of Persistent Atrial Fibrillation: Insights From the Real-AF Registry. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-05-31 Esseim Sharma,Allyson Varley,Jose Osorio,Christopher Thorne,Paul Varosy,Mark Metzl,Anil Rajendra,Saumil Oza,Gustavo Morales,Anthony Magnano,Benjamin D'Souza,Matthew Sackett,Matthew Sellers,Jose Silva,Joshua Silverstein,Jeffrey Ho,Michael Hoskins,Richard Kuk,Jorge Romero,Paul C Zei
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Pulsed Field Versus Cryoballoon Pulmonary Vein Isolation for Atrial Fibrillation: Efficacy, Safety, and Long-Term Follow-Up in a 400-Patient Cohort. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-05-31 Lukas Urbanek,Stefano Bordignon,David Schaack,Shaojie Chen,Shota Tohoku,Tolga Han Efe,Ramin Ebrahimi,Francesco Pansera,Jun Hirokami,Karin Plank,Alexander Koch,Britta Schulte-Hahn,Boris Schmidt,Kyoung-Ryul Julian Chun
BACKGROUND The cryoballoon (CB) represents the gold standard single-shot device for pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF). Single-shot pulsed field PVI ablation (nonthermal, cardiac tissue selective) has recently entered the arena. We sought to compare procedural data and long-term outcome of both techniques. METHODS Consecutive AF patients who underwent pulsed field
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Outcomes After Development of Ventricular Arrhythmias in Single Ventricular Heart Disease Patients With Fontan Palliation. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-05-31 Heather M Giacone,Henry Chubb,Anne M Dubin,Kara S Motonaga,Scott R Ceresnak,William R Goodyer,Debra Hanisch,Anthony V Trela,Nicole Boramanand,Erin Lencioni,Derek Boothroyd,Anna Graber-Naidich,Gail Wright,Christiane Haeffele,Seth A Hollander,Doff B McElhinney,Michael Ma,Frank L Hanley,Sharon Chen
BACKGROUND With the advent of more intensive rhythm monitoring strategies, ventricular arrhythmias (VAs) are increasingly detected in Fontan patients. However, the prognostic implications of VA are poorly understood. We assessed the incidence of VA in Fontan patients and the implications on transplant-free survival. METHODS Medical records of Fontan patients seen at a single center between 2002 and
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Far From Simple: The Search for a Universal Cardiac Resynchronization Programming Algorithm. Circ. Arrhythmia Electrophys. (IF 8.4) Pub Date : 2023-05-29 Rohit Malhotra,Pamela K Mason