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How to mange differential hypoxemia during veno-arterial extracorporeal membrane oxygenation Perfusion (IF 1.2) Pub Date : 2024-03-16 Xiaotong Hou
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Effect of blood conservation protocol on the utilisation of blood and outcome of patients undergoing open heart surgery Perfusion (IF 1.2) Pub Date : 2024-03-16 Vivek Bagaria, Lahari Badragiri, C S Hiremath
IntroductionCardiac surgery is fraught with increased consumption of blood and blood products. Various strategies for blood conservation have been described. Our aim was to study the impact of a structured blood conservation protocol (BCP) on the utilization of blood and patient outcome.MethodsRetrospective analysis of prospectively collected data comparing adult patients undergoing open heart surgery
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The association between cerebral blood flow variations during on-pump coronary artery bypass grafting surgery and postoperative delirium Perfusion (IF 1.2) Pub Date : 2024-03-15 Caterina Sampaolesi, Erika Casarotta, Giacomo Gresti, Giulia Mariotti, Leonardo Pisani, Diego Veccia, Marco Di Eusanio, Pietro Giorgio Malvindi, Abele Donati, Christopher Maria Münch
IntroductionPostoperative delirium (POD) has a major impact on patient recovery after cardiac surgery. Although its pathophysiology remains unclear, there could be a correlation between cerebral blood flow (CBF) variations during cardio-pulmonary bypass (CPB) and POD. Our study aimed to evaluate whether variations in on-pump CBF, compared to pre-anesthesia and pre-CPB values, are associated with POD
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Effect of oxygen delivery during cardiopulmonary bypass on postoperative neurological outcomes in patients undergoing cardiac surgery: A scoping review of the literature Perfusion (IF 1.2) Pub Date : 2024-03-15 Abdelrahman Elsebaie, Ayesha Shakeel, Shetuan Zhang, Marianne Alarie, Mohamed El Tahan, Mohammad El-Diasty
BackgroundReduced oxygen delivery (DO2) during cardiopulmonary bypass (CPB) was proposed as a risk factor for the development of postoperative neurological complications (PONCs), including cerebrovascular accidents (CVA), delirium, and postoperative cognitive dysfunction (POCD). We aimed to review the current evidence on the association between intraoperative DO2 and the incidence of PONCs.MethodsMEDLINE
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Extracorporeal cardio-pulmonary resuscitation in a patient with missed diagnosis of sodium nitrite intoxication Perfusion (IF 1.2) Pub Date : 2024-03-15 Francesco Gaiani, Marco Giani, Beatrice Vergnano, Jeff Sardella, Fabrizio Cappellini, Marco Casati, Matteo Pozzi, Giuseppe Foti
IntroductionCritical poisoning with sodium nitrite (NaNO2) can present challenges in promptly identifying and managing acute methemoglobinemia.Case reportWe report the case of an overt self-intoxication by an initially unknown agent, leading to cardiac arrest. Despite prodromal signs of cyanosis, coma, desaturation, and hypotension, methemoglobinemia went unrecognized during extracorporeal cardiopulmonary
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Utilizing cell salvage devices to return blood post extracorporeal membrane oxygenation circuit decannulation, A Letter to the Editor Perfusion (IF 1.2) Pub Date : 2024-03-14 Mazen F Odish, Samira Najmaii, Cassia Yi, Travis L Pollema
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Letter re: Loss of pioneer physician perfusionist Perfusion (IF 1.2) Pub Date : 2024-03-14 Dereck Wheeldon
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Meta-analysis of central and peripheral cannulation for type A aortic dissection Perfusion (IF 1.2) Pub Date : 2024-03-13 Noritsugu Naito, Hisato Takagi
BackgroundAcute type A aortic dissection necessitates rapid and effective arterial cannulation techniques for optimal outcomes. This meta-analysis compares the safety and effectiveness of direct aortic cannulation (AoC) with peripheral cannulation (PC) via the femoral or axillary arteries in aortic surgery for acute type A aortic dissection.MethodsA systematic review following PRISMA guidelines identified
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Comparing clinical outcomes of hybrid coronary revascularization with open coronary artery bypass in patients with multi-vessels lesions Perfusion (IF 1.2) Pub Date : 2024-03-08 Ji Lin, Guang Li, Yuan Ji, Yi Xu, Shuo Liu, Zheng Qu, Ping Li, Bin You
ObjectivesHybrid coronary revascularization (HCR) involves the use of minimally invasive direct coronary artery bypass grafting (CABG) to treat the left anterior descending artery (LAD), and percutaneous coronary intervention to treat non-LAD vessels. We reported the results of a comparative analysis between HCR and off-pump CABG via sternotomy (OPCABG).MethodsData were retrospectively collated from
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Endarterectomy may be an effective additional treatment for three diffuse coronary artery disease complicated with diabetes Perfusion (IF 1.2) Pub Date : 2024-03-06 Haiming Li, Chengxiong Gu, Bo Li
ObjectiveIn order to evaluate the clinical efficacy of coronary endarterectomy (CE) and coronary artery bypass grafting (CABG) in patients with diabetes complicated with three diffuse coronary artery stenosis.MethodsA retrospective analysis was conducted on 460 patients with diabetes mellitus and diffuse three-vessel coronary artery disease who underwent CABG in our department from September 2015 to
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Concomitant interventions in mitral valve surgery – A European perspective Perfusion (IF 1.2) Pub Date : 2024-03-02 Vinci Naruka, Arian Arjomandi Rad, Jacob Chacko, Guiqing Liu, Jonathan Afoke, Prakash P Punjabi
IntroductionIn recent years, major findings on concomitant procedures and anticoagulation management have occurred in Mitral Valve (MV) surgery. Therefore, we sought to evaluate the current practices in MV interventions across Europe.MethodsIn October 2021, all national cardio-thoracic societies in the European region were identified following an electronic search and sent an online survey of 14 questions
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The effect of air-free administration of intravenous drugs on microemboli during cardiopulmonary bypass Perfusion (IF 1.2) Pub Date : 2024-02-29 Amber den Ouden, Marco C Stehouwer, Bernd Geurts, Erik Hofman, Peter Bruins
ObjectiveDuring cardiopulmonary bypass (CPB), gaseous microemboli (GME) that originate from the extracorporeal circuit are released into the arterial blood stream of the patient. Gaseous microemboli may contribute to adverse outcome after cardiac surgery with CPB. Possibly, air may be collected in the right atrium during induction of anesthesia and released during CPB start. The aim of this study was
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The effects of prone position ventilation on patients with acute respiratory distress syndrome after cardiac surgery Perfusion (IF 1.2) Pub Date : 2024-02-27 Yujie Zhang, Wangtao Zhou, Jing Ma
BackgroundThis study aimed to investigate the effects of prone position ventilation treatment on patients with acute respiratory distress syndrome (ARDS) after cardiac surgery.MethodsClinical data were collected from 93 hospitalized patients with acute respiratory distress syndrome (ARDS) in the intensive care unit (ICU) of cardiology from February 2021 to February 2023. Patients were divided into
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Perfusion education and training in Europe anno 2023 Perfusion (IF 1.2) Pub Date : 2024-02-27 Gerdy Debeuckelaere
Background: In the absence of uniform European regulations, there have been many differences in the training of perfusionists across Europe. Furthermore, there has been no uniform or single European accreditation of the profession. One of the objectives of The European Board of Cardiovascular Perfusion (EBCP) is to standardise and monitor training of perfusionists across Europe whilst offering support
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Assessment of a goal-directed perfusion strategy through an oxygen delivery audit Perfusion (IF 1.2) Pub Date : 2024-02-27 Andrew Lahanas, Paul W Argerakis, Beatrice A Hayward, Peter W Grant
IntroductionEvidence supports the role of oxygen delivery (DO2) in ameliorating acute kidney injury (AKI). While instrumentation for continuous DO2 measurement exists, a simplified method has been reported for targeting a specific DO2 index (DO2i), commonly referred to as a goal-directed perfusion (GDP) strategy, by using a reference table and available data such as body surface area and continuous
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Negative pressure therapy for ECMO cannula stabilization Perfusion (IF 1.2) Pub Date : 2024-02-24 Jennifer Gauntt, Virginia Kathleen Cox, Vicky Duffy, Matt Deitemyer, Eric Lloyd, Amee Bigelow, Patrick McConnell, Janet Simsic
Cannula stabilization for extracorporeal membrane oxygenation (ECMO) is important for patient mobilization and rehabilitation. Limitations to mobilization on ECMO include staff discomfort and cannula instability. We utilized the technique of negative pressure therapy for ECMO cannula stabilization to improve mobilization. Negative pressure therapy for ECMO cannula stabilization can be utilized safely
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Comparison of different porcine models simulating myocardial cold ischemia of pediatric donor hearts Perfusion (IF 1.2) Pub Date : 2024-02-23 Yuriy Stukov, Mark S Bleiweis, Laura Wilson, Giles J Peek, Keith March, Elaine M Richards, Edward D Staples, Jeffrey P Jacobs
BackgroundOur team previously identified a stem cell-derived cardioprotective additive that can be added to standard cardioplegia to extend myocardial viability during prolonged myocardial cold ischemic time (CIT) in rodent models. The purpose of this study was to utilize a porcine model to compare in-vivo versus ex-vivo porcine simulation of CIT that accompanies cardiac transplantation in humans,
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Thromboelastography versus thromboelastometry for unfractionated heparin monitoring in adult patients on extracorporeal membrane oxygenation Perfusion (IF 1.2) Pub Date : 2024-02-21 Ellen B Yin, Arthur W Bracey, Subhasis Chatterjee
Background: Monitoring the anticoagulant effect of unfractionated heparin (UFH) in extracorporeal membrane oxygenation (ECMO) patients is complex but critically important to balance the risks of treatment related bleeding and circuit thrombosis. While guidelines recommend using more than one method to monitor UFH activity, the use of thromboelastometry (ROTEM) to monitor UFH in ECMO patients has not
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Preserving flow, saving lives: Successful treatment of aortic valve failure in acute myocardial infarction without flow down-regulation using ECMO - a case report and mini review Perfusion (IF 1.2) Pub Date : 2024-02-07 Jing Yang, Xiao-Kang Zeng, Wei Hu, Ying Zhu
Direct percutaneous coronary intervention (PPCI) has significantly reduced cardiac mortality in patients with acute myocardial infarction (AMI), but the mortality rate remains high for those who develop cardiogenic shock (CS), reaching 40% to 50%. Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) provides robust hemodynamic support and oxygen delivery for AMI patients with refractory CS
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Hypobaric type oxygenators – physics and physiology Perfusion (IF 1.2) Pub Date : 2024-02-07 Phatiwat Chotimol, William Lansdowne, David Machin, Kressle Binas, Gianni D Angelini, Ben Gibbison
Brain injury is still a serious complication after cardiac surgery. Gaseous microemboli (GME) are known to contribute to both short and longer-term brain injury after cardiac surgery. Hypobaric and novel dual-chamber oxygenators use the physical behaviors and properties of gases to reduce GME. The aim of this review was to present the basic physics of the gases, the mechanism in which the hypobaric
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Improving the effectiveness of CPR during interventional procedures Perfusion (IF 1.2) Pub Date : 2024-02-02 Christopher Gaisendrees, Kaveh Eghbalzadeh, Matti Adam, Ilija Djordjevic, Oliver Mehler, Thorsten Wahlers, Elmar W Kuhn
IntroductionThe number of interventional procedures, such as transcatheter aortic valve replacements or thoracic endovascular aortic repairs, is on the rise. Intraprocedural cardiac arrest is a rare occurrence during high-risk procedures. Modern hybrid-operating tables may adversely affect chest compression quality due to their flexibility. To investigate this relationship, we analyzed the blood pressure
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Vacuum assisted and gravitational venous drainage in aortic valve surgery: A propensity-match study Perfusion (IF 1.2) Pub Date : 2024-01-26 Raffaele Silvano, Pietro Giorgio Malvindi, Francesca Mazzocca, Stefania Genova, Emanuele Di Campli, Francesca Paterna, Jacopo M. D’Este, Jacopo Alfonsi, Paolo Berretta, Christopher Munch, Marco Di Eusanio
IntroductionVacuum assisted venous drainage (VAVD) is widely adopted in minimally invasive cardiac surgery. VAVD enables the advantage of using smaller cannulae in a reduced surgical field while allowing satisfactory drainage and pump flow. The production of gaseous micro-emboli is a recognized risk associated with VAVD, however no difference in clinical endpoints have been reported between patients
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Liberal use of veno-arterial extracorporeal membrane oxygenation in combined sequential heart-liver transplantation Perfusion (IF 1.2) Pub Date : 2024-01-23 Alice V Vinogradsky, Stephanie N Nguyen, Abhishek Mathur, Koji Takeda
Combined heart-liver transplantation (CHLT) is a rarely though increasingly performed procedure with evolving indications. Despite CHLT being performed at only a handful of centers, the use of intraoperative mechanical circulatory support to optimize hemodynamics and facilitate dual-organ transplantation varies widely. At our center, we liberally utilize veno-arterial extracorporeal membrane oxygenation
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Long-term results of percutaneous coronary intervention in no-touch vein grafts are significantly better than in conventional vein grafts Perfusion (IF 1.2) Pub Date : 2024-01-23 Gabriele Ferrari, Håkan Geijer, Yang Cao, Ulf Graf, Leif Bojö, Roland Carlsson, Domingos Souza, Ninos Samano
IntroductionConventional vein grafts have a high risk of thrombosis and early atherosclerosis. Percutaneous coronary intervention (PCI) in conventional vein grafts is associated with a higher incidence of late adverse cardiac events. The aim of this study was to evaluate the long-term results after PCI in saphenous vein grafts (SVG) harvested with the no-touch technique compared to the conventional
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Multiple thromboses, including intracardiac thrombi, accompanied by HIT during ECMO successfully treated with NOACs: A case report Perfusion (IF 1.2) Pub Date : 2024-01-19 Won-Sik Yun, Sanghyo Kim, Lae-Young Jung
IntroductionUnfractionated heparin remains the mainstay of anticoagulation therapy during extracorporeal membrane oxygenation (ECMO) maintenance. However, its continued use in clinical practice exposes patients to the risk of developing heparin-induced thrombocytopenia (HIT).Case ReportA 50-year-old male was diagnosed with multiple thromboses, including an intracardiac thrombi, accompanied by HIT during
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The use of protective mechanical ventilation during extracorporeal membrane oxygenation for the treatment of acute respiratory failure Perfusion (IF 1.2) Pub Date : 2024-01-19 Julian Kingsley, Omneya Kandil, Joshua Satalin, Akram Abdel Bary, Sierra Coyle, Mahmoud Saad Nawar, Robert Groom, Amr Farrag, Jaffer Shah, Ben R Robedee, Edward Darling, Ahmed Shawkat, Debanik Chaudhuri, Gary F Nieman, Hani Aiash
Acute respiratory failure (ARF) strikes an estimated two million people in the United States each year, with care exceeding US$50 billion. The hallmark of ARF is a heterogeneous injury, with normal tissue intermingled with a large volume of low compliance and collapsed tissue. Mechanical ventilation is necessary to oxygenate and ventilate patients with ARF, but if set inappropriately, it can cause
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Severe COVID-19 post pregnancy complicated by acute thromboemboli resulting in ST-elevation myocardial infarction – A case report Perfusion (IF 1.2) Pub Date : 2024-01-18 Danni Fu, Byung Joon Park, Gaurav Rao, John Makaryus
Introduction: It has been shown that pregnancy can cause alterations in the severity of COVID-19 infection. We demonstrate an immediate post-partum patient diagnosed with severe COVID-19 and subsequently developed acute thrombosis of coronary artery.Case Summary: 35-year-old female unvaccinated for COVID-19 presented in labor and delivered on the same day. Several hours later, she was found to be in
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The correlation of non-invasive hemoglobin testing and lab hemoglobin in surgical patients: A systematic review and meta-analysis Perfusion (IF 1.2) Pub Date : 2024-01-17 Jamil Kazma, Megan Ebner, James Slota, Jeffery S. Berger, Fouzia Farooq, Emily Smith, Homa K. Ahmadzia
BackgroundThe decision regarding intraoperative transfusion has traditionally been based on hemodynamic instability and estimated blood loss. We performed a systematic review to determine the validity of the oximetry method compared to standard of care for hemoglobin measurement.MethodsA systematic literature review was conducted, and several libraries were searched from inception to March 31,2023
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The biological role and future therapeutic uses of nitric oxide in extracorporeal membrane oxygenation, a narrative review Perfusion (IF 1.2) Pub Date : 2024-01-16 Lindsey Brinkley, Michael A Brock, Griffin Stinson, Ahmet Bilgili, Jeffrey Jacobs, Mark Bleiweis, Giles J Peek
BackgroundNitric oxide (NO) is a gas naturally produced by the human body that plays an important physiological role. Specifically, it binds guanylyl cyclase to induce smooth muscle relaxation. NO’s other protective functions have been well documented, particularly its protective endothelial functions, effects on decreasing pulmonary vascular resistance, antiplatelet, and anticoagulation properties
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Impact of pulmonary hypertension on short-term outcomes in patients undergoing surgical aortic valve replacement for severe aortic valve stenosis Perfusion (IF 1.2) Pub Date : 2024-01-12 Borko Ivanov, Ihor Krasivskyi, Friedrich Förster, Christopher Gaisendrees, Ahmed Elderia, Clara Großmann, Mariya Mihaylova, Ilija Djordjevic, Kaveh Eghbalzadeh, Anton Sabashnikov, Elmar Kuhn, Antje-Christin Deppe, Parwis Baradaran Rahmanian, Navid Mader, Stephen Gerfer, Thorsten Wahlers
ObjectivesIn patients with left heart disease and severe aortic stenosis (AS), pulmonary hypertension (PH) is a common comorbidity and predictor of poor prognosis. Untreated AS aggravates PH leading to an increased right ventricular afterload and, in line to right ventricular dysfunction. The surgical benefit of aortic valve replacement (AVR) in elderly patients with severe AS and PH could be limited
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Relationship between difference of preoperative and cardiopulmonary bypass mean arterial pressure, and acute kidney injury in cardiac surgical patients undergoing valve surgery Perfusion (IF 1.2) Pub Date : 2024-01-06 Anity Singh Dhanyee, Satyen Parida, Chitra Rajeswari Thangaswamy, Ajay Kumar Jha, Medha Rajappa, Hemachandren Munuswamy, Sandeep Kumar Mishra
BackgroundModifiable and non-modifiable factors contribute to development and progression of acute kidney injury (AKI) during cardiac surgery. We hypothesized that, the difference between preoperative mean arterial pressure (MAP) and the average mean arterial pressure maintained on cardiopulmonary bypass (CPB) would be strongly predictive of AKI. We also measured plasma Neutrophil gelatinase-associated
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“Extracorporeal membrane oxygenation outcomes in multisystem inflammatory syndrome of childhood – An extracorporeal life support organization registry study”, Perfusion (IF 1.2) Pub Date : 2024-01-05 Noah Miller, Hitesh S Sandhu, Pilar Anton-Martin
Multisystem inflammatory disease in childhood (MIS-C) is a novel pediatric syndrome after a COVID-19 infection that causes systemic injury, with potential life-threatening hemodynamic compromise requiring Extracorporeal Membrane Oxygenation (ECMO) support. We performed an observational retrospective cohort study in children aged 0-18 years with MIS-C and non-MIS-C myocarditis on ECMO between January
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Perioperative oxygenation impairment related to type a aortic dissection Perfusion (IF 1.2) Pub Date : 2024-01-04 Qindong Liu, Yulong Guan, Xiaofang Yang, Yu Jiang, Feilong Hei
Type A aortic dissection (TAAD) is a life-threatening disease with high mortality and poor prognosis, usually treated by surgery. There are many complications in its perioperative period, one of which is oxygenation impairment (OI). As a common complication of TAAD, OI usually occurs throughout the perioperative period of TAAD and requires prolonged mechanical ventilation (MV) and other supportive
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Dabigatran pharmacokinetic-pharmacodynamic in sheep: Informing dose for anticoagulation during cardiopulmonary bypass Perfusion (IF 1.2) Pub Date : 2024-01-04 Michael P Eaton, Sergiy M Nadtochiy, Tatsiana Stefanos, Brian J Anderson
BackgroundThe effect of the anticoagulant, dabigatran, and its antagonist, idarucizumab, on coagulation remains poorly quantified. There are few pharmacokinetic-pharmacodynamic data available to determine dabigatran dose in humans or animals undergoing cardiopulmonary bypass.MethodsFive sheep were given intravenous dabigatran 4 mg/kg. Blood samples were collected for thromboelastometric reaction time
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Carbon dioxide production index (VCO2i) predicts hyperlactatemia during cardiopulmonary bypass in pediatric carDiac surGery (pGDP- VCO2i): Study protocol for a nested case-control trial Perfusion (IF 1.2) Pub Date : 2024-01-03 Yan Zhang, Hui Xiong, Bo Wang, Ming Luo, Ting Liu, Zhen Qin, Jin-Ge Fan, Rong-Hua Zhou
BackgroundHyperlactatemia (HL) during cardiopulmonary bypass (CPB) is relatively frequent in infants and associates with increased morbidity and mortality. Studies on adults have shown that carbon dioxide production index (VCO2i) during CPB is linked to the occurrence of HL, with ‘critical thresholds’ for VCO2i reported to be 60 mL/min/m2. However, considering infants have a higher metabolic rate and
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"Let's play a different game" - virtual reality in extracorporeal membrane oxygenation simulation. Perfusion (IF 1.2) Pub Date : 2023-11-18 Justyna Swol,John M Toomasian
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Influence of minimal invasive extracorporeal circuits on dialysis dependent patients undergoing cardiac surgery. Perfusion (IF 1.2) Pub Date : 2023-11-17 Thai Duy Nguyen,Mohammed Morjan,Khaldoun Ali,Ingo Breitenbach,Wolfgang Harringer,Aschraf El-Essawi
INTRODUCTION Cardiac surgery in patients on chronic renal dialysis is associated with significant morbidity and mortality. Minimally invasive extracorporeal circuits (MiECC) have shown a positive impact on patient outcome in different high-risk populations. This retrospective study compares the outcome of these high-risk patients undergoing heart surgery either with a MiECC or a conventional extracorporeal
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Lower extremity complications in children following femoral cannulation for extracorporeal membrane oxygenation. Perfusion (IF 1.2) Pub Date : 2023-11-17 Nikhil R Shah,Brianna L Spencer,Kathryn M Maselli,Keyonna M Williams,Vikram Sood,Samir K Gadepalli,Arul S Thirumoorthi
INTRODUCTION Extracorporeal membrane oxygenation cannulation strategies vary between adults and children. Femoral approach is common in adults and extremity morbidity is well-documented. Aside from limb ischemia, complications in children are theorized and have yet to be studied. This study aims to comprehensively evaluate implications of pediatric femoral cannulation. METHODS This is a single-center
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Outcomes associated with prolonged ECMO in COVID-19 associated ARDS: A single center experience. Perfusion (IF 1.2) Pub Date : 2023-11-16 Purav Shah,Casey Miller,Gustavo Parilla,Mani Daneshmand,Christina Creel-Bulos
PURPOSE OF STUDY The COVID-19 pandemic has led to a significant increase in the use of veno-venous extracorporeal membrane oxygenation (V-V ECMO) as a bridge to transplantation versus recovery. Unlike other etiologies of acute respiratory distress syndrome (ARDS), utilization of V-V ECMO in COVID-19 has been associated with longer duration of ECMO support requirements. Our team sought to evaluate outcomes
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Catheter thrombectomy for basilar artery stroke immediately after insertion of durable left ventricular assist device. Perfusion (IF 1.2) Pub Date : 2023-11-15 Vasiliki Gregory,Ameesh Isath,Atul D Bali,Fawaz Al-Mufti,Avi Levine,Masashi Kai,Suguru Ohira
Background: Acute ischemic stroke (AIS) following left ventricular assist device (LVAD) implantation is a serious complication associated with device morbidity. AIS development following LVAD placement typically presents between 6- and 24-months post implantation.Case/Results: We report a case of a 67-year-old male who initially presented with reduced ejection fraction and severe coronary vessel disease
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Redosing of long acting cardioplegic solutions in adult cardiac surgery: A comparative study. Perfusion (IF 1.2) Pub Date : 2023-11-15 Serdar Gunaydin,Kevin McCusker,William Nicotra
INTRODUCTION Despite promising results regarding using long-acting cardioplegia in the adult population, little data exists specifically for operations requiring prolonged aortic cross-clamp needing additional doses. In this pilot study, we evaluated the outcomes of patients undergoing surgery with prolonged cross-clamp time based on four different redosing compositions. METHODS During the period from
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Perioperative changes in coagulation and platelet contribution to clot strength after transcatheter aortic valve implantation: A study using thromboelastography and conventional markers. Perfusion (IF 1.2) Pub Date : 2023-11-14 Takeyuki Sajima,Mae Harada,Taichi Onimaru,Takahiro Honjo,Taisuke Mizuguchi,Atsushi Yasuda,Shigehito Swamura,Hirofumi Hioki,Yusuke Watanabe
INTRODUCTION Thrombotic and haemorrhagic complications have been reported following transcatheter aortic valve implantation (TAVI). However, few reports have studied perioperative changes in coagulation and platelet function after TAVI. Furthermore, there are no clear guidelines for antithrombotic therapy. This study aimed to examine the perioperative changes in coagulation and platelet contribution
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Angiotensin-II for vasoplegia following cardiac surgery. Perfusion (IF 1.2) Pub Date : 2023-11-13 Andrew J Johnson,William Tidwell,Andrew McRae,C Patrick Henson,Antonio Hernandez
INTRODUCTION The objective of this study was to describe the implementation and outcomes of a protocol outlining angiotensin-II utilization for vasoplegia following cardiac surgery. METHODS This was a retrospective chart review at a single-center university hospital. Included patients received angiotensin-II for vasoplegia refractory to standard interventions, including norepinephrine 20 mcg/min and
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Intracranial hemorrhage in a large cohort of patients supported with veno-venous ECMO. A retrospective single-center analysis. Perfusion (IF 1.2) Pub Date : 2023-11-10 Clemens Wiest,Thomas Müller,Matthias Lubnow,Christoph Fisser,Alois Philipp,Maik Foltan,Roland Schneckenpointner,Maximilian V Malfertheiner
BACKGROUND Intracranial bleeding (ICB) is a serious complication during veno-venous extracorporeal membrane oxygenation (V-V ECMO), with potentially fatal consequences. PURPOSE This study aimed to evaluate the incidence, time of detection of ICB among patients treated with V-V ECMO and potential risk factors for developing ICB during V-V ECMO. METHODS Five hundred fifty six patients were included in
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Del Nido cardioplegia in adult cardiac surgery: Clinical outcomes in a single center all-comer study. Perfusion (IF 1.2) Pub Date : 2023-11-09 Lorenzo Di Bacco,Fabrizio Rosati,Alberto Repossini,Massimo Baudo,Mauro Renghini,Debora Maddinelli,Francesca Boldini,Francesca Zanin,Cesare Tomasi,Claudio Muneretto,Stefano Benussi
INTRODUCTION The use of Del Nido Cardioplegia (DNC) has been extended in the latest years from pediatrics to adult cardiac surgery with encouraging results. We sought to investigate clinical and biochemical outcomes in adult patients who underwent cardiac surgery with different degrees of complexity who received DNC for myocardial protection. METHODS Data on one-thousand patients were retrospectively
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Heparin consumption and inflammatory response according to the coating of cardiopulmonary bypass circuits in cardiac surgery: A retrospective analysis. Perfusion (IF 1.2) Pub Date : 2023-11-09 Laurent Mathieu,Antoine Beurton,Nicolas Rougier,Maude Flambard,Christine Germain,Mathieu Pernot,Alexandre Ouattara
INTRODUCTION There are several types of surface treatments (coatings) aimed at improving the biocompatibility of cardiopulmonary bypass (CPB) circuit. Some coatings appear to require higher doses of heparin to maintain anticoagulation goals, and some of them might induce postoperative coagulopathy. In this study, we compared the amount of heparin required, postoperative bleeding, and inflammatory response
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A patient with acute myocardial infarction with acute lower extremity arterial embolization underwent amputation under general anesthesia. Perfusion (IF 1.2) Pub Date : 2023-11-08 Yanjun Lin,Yanyan Xue,Yalei Han,Tongxin Bao,Jing Xue,Liangyuan Lu
INTRODUCTION Acute peripheral and coronary artery embolism are common complications of diabetes mellitus and greatly affect the clinical outcome of patients with diabetes; however, there are few reports about the symptoms and prognosis of patients with acute myocardial infarction (AMI) and concurrent acute lower extremity arterial embolism (ALEAE). CASE PRESENTATION A 44-year-old man with a history
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Health-related quality of life assessment instruments for extracorporeal membrane oxygenation survivors: A scoping review. Perfusion (IF 1.2) Pub Date : 2023-11-07 Anqi Yu,Meng Zhang,Yi Wang,Li Yan,Chunling Guo,Juan Deng,Jie Xiong
BACKGROUND AND OBJECTIVE Extracorporeal membrane oxygenation (ECMO) has been successfully and widely used in adult patients for the past 5 years. About 50% of these patients can survive and are discharged from hospitals. Health-related quality of life (HRQOL) is crucial for evaluating survived ECMO patients. This scoping review aims to identify instruments commonly used to measure HRQOL of ECMO survivors
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Mortality on extracorporeal membrane oxygenation: Evaluation of independent risk factors and causes of death during venoarterial and venovenous support. Perfusion (IF 1.2) Pub Date : 2023-11-07 Johannes Deinzer,Alois Philipp,Lukasz Kmiec,Jing Li,Sigrid Wiesner,Sebastian Blecha,Walter Petermichl,Matthias Lubnow,Daniele Camboni,Christof Schmid,Andrea Stadlbauer
INTRODUCTION Most patients on extracorporeal membrane oxygenation (ECMO) decease during therapy on the system. However, the actual causes of death have not been studied sufficiently. This study analyses the etiology, prevalence, and risk factors for the outcome variable death during ongoing ECMO for all patients and divided according to venoarterial (VA) or venovenous (VV) support. METHODS We retrospectively
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A prospective feasibility trial exploring novel biomarkers for neurotoxicity after isolated limb perfusion. Perfusion (IF 1.2) Pub Date : 2023-11-07 Anna Corderfeldt Keiller,Markus Axelsson,Gudrun Bragadottir,Kaj Blennow,Henrik Zetterberg,Roger Olofsson Bagge
BACKGROUND Isolated limb perfusion (ILP) is a regional cancer treatment in which high-dose chemotherapy is administered in an isolated extremity. The main side effect is regional toxicity, which occasionally leads to nerve damage. Measuring neuroaxonal biomarkers, might be a method predicting such complications. Therefore, the primary aim of the study is to investigate if neuronal biomarkers are measurable
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Standardized nomenclature for peripheral percutaneous cannulation of the pulmonary artery in extracorporeal membrane oxygenation: Current uptake and recommendations for improvement. Perfusion (IF 1.2) Pub Date : 2023-11-06 J Michael Brewer,L Mikael Broman,Justyna Swol,Roberto Lorusso,Steven A Conrad,Marc O Maybauer
The rising application of extracorporeal membrane oxygenation (ECMO) has emphasized the need for consistent and standardized terminology, especially concerning peripheral percutaneous cannulation of the pulmonary artery (PPC-PA). The Extracorporeal Life Support Organization (ELSO) Nomenclature Task Force produced the ELSO Maastricht Treaty for extracorporeal life support (ECLS) Nomenclature to address
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The rare case of double valve surgery in a patient with factor VII deficiency. Perfusion (IF 1.2) Pub Date : 2023-10-31 Friederike I Schoettler,Ali Fatehi Hassanabad,Michael H Chiu,Andre Ferland,Corey Adams
Performing cardiac surgery on patients with bleeding diatheses poses significant challenges since these patients are at an increased risk for complications secondary to excessive bleeding. Despite its rarity, patients with factor VII (FVII) deficiency may require invasive procedures such as cardiac surgery. However, we lack guidelines on their pre-, peri-, and post-operative management. As FVII deficiency
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Cardiac surgery-Associated acute kidney injury - A narrative review. Perfusion (IF 1.2) Pub Date : 2023-10-31 Sebastian Buhl Rasmussen,Yuliya Boyko,Marco Ranucci,Filip de Somer,Hanne Berg Ravn
Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) is a serious complication seen in approximately 20-30% of cardiac surgery patients. The underlying pathophysiology is complex, often involving both patient- and procedure related risk factors. In contrast to AKI occurring after other types of major surgery, the use of cardiopulmonary bypass comprises both additional advantages and challenges
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A comparison of the efficacy and safety between anticoagulation alone and combined with catheter-directed thrombolysis for treatment of pulmonary embolism on outcome: A systematic review and meta-analysis. Perfusion (IF 1.2) Pub Date : 2023-10-30 Bing Sun,Rui Rui Chen
BACKGROUND Catheter-directed thrombolysis (CDT) is one of the newest treatment options for submassive pulmonary embolism (sPE). This study will compare the efficacy and safety of catheter-directed thrombolysis (CDT) combine with anticoagulation versus anticoagulation alone (AC) in patients with PE. METHODS A database search was conducted using PubMed, EMBASE, Cochrane Library, and Clinicaltrials.gov
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"Drum Tower Hospital" strategy for acute type A aortic dissection with coma. Perfusion (IF 1.2) Pub Date : 2023-10-26 Ya-Peng Wang,Li-Chong Lu,Shu-Chun Li,Li Li,Yi Jiang,Yong-Qing Cheng,Min Ge,Yang Chen,Dong-Jin Wang
OVERVIEW Acute type A aortic dissection (ATAAD) with persistent coma is a life-threatening condition associated with high mortality and poor neurological outcomes. The optimal timing for surgical intervention in these patients remains uncertain, and many patients are not eligible for surgery due to their poor prognosis. DESCRIPTION In this case, a 53-year-old man with hypertension presented to the
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Pediatric extracorporeal cardiopulmonary resuscitation for yew cardiotoxicity. Perfusion (IF 1.2) Pub Date : 2023-10-24 Zachary Daniels,Hannah Hays,Sergio Carrillo,Anna Kamp,Jennifer Gauntt
INTRODUCTION English yew is an evergreen conifer frequently planted in household gardens and, when ingested in large doses, results in severe cardiotoxicity characterized by difficult to control ventricular arrhythmias with high rates of mortality. CASE REPORT A previously healthy teenage female presented as an out-of-hospital cardiac arrest with refractory ventricular arrhythmias and severe biventricular
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Is cardioplegia system pressure the optimal measure of coronary perfusion during antegrade cardioplegia delivery? A critical review of pressure measurements for optimal antegrade delivery. Perfusion (IF 1.2) Pub Date : 2023-10-19 Allison Hacker,Peter Maggs,Patrick Treanor,Kevin Lilly,Vladimir Birjiniuk
Antegrade cardioplegia is routinely given during cardiac surgery. The delivery of antegrade cardioplegia from the cardiopulmonary bypass machine has many variables. Many perfusionists rely exclusively on cardioplegia system pressure to ensure safe antegrade delivery. Our group reviewed antegrade cardioplegia delivery in 50 patients undergoing coronary artery bypass graft. The data collected included
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Cardiopulmonary exercise testing augments watchful waiting in asymptomatic severe primary mitral regurgitation. Perfusion (IF 1.2) Pub Date : 2023-10-18 Jonathan Afoke,Jagdeep Mohal,Gajen Sunthar Kanaganayagam,Roberto Casula,Vito Bruno,Luke Howard,Simon Gibbs,Prakash Punjabi
INTRODUCTION Our aim is to describe the use of cardiopulmonary exercise testing in watchful waiting for asymptomatic severe primary mitral regurgitation. METHODS Between October 2016 and October 2017, ten patients with asymptomatic severe primary mitral regurgitation underwent watchful waiting in a single centre. Baseline assessment included history, physical examination, transthoracic echocardiogram
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Use of prone position ventilation in patients with COVID-19 induced severe ARDS supported with V-V ECMO: A danish cohort study with focus on adverse events. Perfusion (IF 1.2) Pub Date : 2023-10-03 Janne Adelsten,Lars Grønlykke,Finn Møller Pedersen,Søren Aalbæk Madsen,Marc Sørensen,Camilla Tofte Eschen,Peter Hasse Møller Sørensen,Jakob Gjedsted,Dorthe Viemose Nielsen,Steffen Christensen,Jonas Nielsen,Vibeke Lind Jørgensen
INTRODUCTION Prone position ventilation (PPV) of patients with adult respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (V-V ECMO) may improve oxygenation and alveolar recruitment and is recommended when extensive dorsal consolidations are present, but only few data regarding adverse events (AE) related to PPV in this group of patients have been published
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Effect of glucocorticoid for patients with type A aortic dissection undergoing surgical repair with deep hypothermic circulatory arrest: A single-center, retrospective study. Perfusion (IF 1.2) Pub Date : 2023-09-30 Ming-Hao Luo,Jia-Qi Chen,Jing-Chao Luo,Jia-Kun Li,Yi-Jie Zhang,Xin Xu,Ying Su,Chun-Sheng Wang,Hao Lai,Yong-Xin Sun,Jun Li,Guo-Wei Tu,Zhe Luo
BACKGROUND Postoperative patients with Type A aortic dissection (TAAD) often experience severe inflammatory responses caused by multiple factors perioperatively. However, the effect of postoperative glucocorticoid (GC) use, which is a potent anti-inflammatory agent, on complications or all-cause mortality is unclear. METHODS Patients with TAAD who underwent surgical repair requiring deep hypothermic