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Sex-specific lifetime risk of cardiovascular events: the European Prospective Investigation into Cancer-Norfolk prospective population cohort study. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-30 Tiberiu A Pana,Mamas A Mamas,Nicholas J Wareham,Kay-Tee Khaw,Dana K Dawson,Phyo K Myint
AIMS Better understanding of sex differences in cardiovascular disease (CVD) is essential in tailoring appropriate preventative strategies. Using a large population-based study with follow-up >25 years, we aimed to determine sex-specific lifetime risks of incident CVD and cardiovascular (CV) mortality amongst populations with and without prevalent CVD. METHODS AND RESULTS Participants were drawn from
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Editorial comments: focus on lipid lowering and weight loss role in cardiovascular prevention. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-30 Andrea Attanasio,Massimo F Piepoli
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Maintaining or increasing cardiorespiratory fitness is associated with reduced hospital admission rate. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-29 Frida Griffin,Elin Ekblom-Bak,Daniel Arvidsson,Sofia Paulsson,Mats Börjesson
AIM To investigate the association between change in cardiorespiratory fitness (CRF) and cardiovascular disease (CVD)-related and all-cause hospital admission, and explore if the association varies dependent on prior admission, baseline CRF, sex, and age. METHODS 91,140 adult participants (41.5% women) with two examinations from occupational health profile assessments between 1986 and 2019 were included
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Management of cardiac and cardiovascular dysfunction postpartum should include support to initiate and continue breastfeeding. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-28 Graeme N Smith,Natalie Dayan
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Polygenic risk scores associate with blood pressure traits across the lifespan. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-26 Karsten Øvretveit,Emma M L Ingeström,Michail Spitieris,Vinicius Tragante,Kaitlin H Wade,Laurent Thomas,Brooke N Wolford,Ulrik Wisløff,Daniel F Gudbjartsson,Hilma Holm,Kari Stefansson,Ben M Brumpton,Kristian Hveem
BACKGROUND AND AIMS Hypertension is a major modifiable cause of morbidity and mortality that affects over 1 billion people worldwide. BP traits have a strong genetic component that can be quantified with polygenic risk scores (PRSs). To date, the performance of BP PRSs has mainly been assessed in adults and less is known about polygenic hypertension risk in childhood. METHODS Multiple PRSs for systolic
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Association between tomato consumption and blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-24 David Murcia-Lesmes,Inés Domínguez-López,Emily P Laveriano-Santos,Anna Tresserra-Rimbau,Sara Castro-Barquero,Ramón Estruch,Zenaida Vazquez-Ruiz,Miguel Ruiz-Canela,Cristina Razquin,Dolores Corella,Jose V Sorli,Jordi Salas-Salvadó,Karla-Alejandra Pérez-Vega,Enrique Gómez-Gracia,José Lapetra,Fernando Arós,Miquel Fiol,Luis Serra-Majem,Xavier Pinto,Emilio Ros,Rosa M Lamuela-Raventós
AIMS Clinical studies have produced conflicting evidence on the effects of the consumption of tomatoes on blood pressure, and there are limited data from epidemiologic studies. This study assesses whether tomato consumption (Solanum lycopersicum L.) is associated with Systolic (SBP) and Diastolic Blood Pressure (DBP), and the risk of hypertension in a prospective 3-year longitudinal study in older
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Drinking patterns of alcohol and risk of major adverse cardiovascular events after an acute coronary syndrome. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-23 Elena Tessitore,Mattia Branca,Dik Heg,David Nanchen,Reto Auer,Lorenz Räber,Roland Klingenberg,Stephan Windecker,Thomas F Lüscher,Sebastian Carballo,Christian M Matter,Gerhard Gmel,Kenneth J Mukamal,Nicolas Rodondi,David Carballo,François Mach,Baris Gencer
AIM To evaluate the risk of alcohol consumption after acute coronary syndromes (ACS). METHODS A total of 6557 patients hospitalized for ACS at 4 Swiss centres were followed over 12 months. Weekly alcohol consumption was collected at baseline and 12 months. Binge drinking was defined as consumption of ≥6 units of alcohol on one occasion. Major adverse cardiovascular events (MACE) were defined as a composite
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Use of secondary prevention medications in metropolitan and non-metropolitan areas: an analysis of 41,925 myocardial infarctions in Australia. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-21 Adam C Livori MClinPharm,Zanfina Ademi,Jenni Ilomäki,Derk Pol,Jedidiah I Morton,J Simon Bell
BACKGROUND People in remote areas may have more difficulty accessing healthcare following myocardial infarction (MI) than people in metropolitan areas. We determined whether remoteness was associated with initial and 12-month use of secondary prevention medications following MI in Victoria, Australia. METHOD We included all people alive at least 90 days post-discharge following MI between July 2012
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Regional and temporal differences in the associations between cardiovascular disease and its classic risk factors: An analysis of 49 cohorts from 11 European countries. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-17 Jaakko Reinikainen,Kari Kuulasmaa,Viktor Oskarsson,Philippe Amouyel,Katia Biasch,Hermann Brenner,Roberto De Ponti,Chiara Donfrancesco,Wojciech Drygas,Jean Ferrieres,Guido Grassi,Sameline Grimsgaard,Licia Iacoviello,Pekka Jousilahti,Line L Kårhus,Frank Kee,Allan Linneberg,Dalia Luksiene,Joany Mariño,Marie Moitry,Luigi Palmieri,Annette Peters,Aleksandra Piwonska,Fosca Quarti-Trevano,Veikko Salomaa,Susana
AIMS The regional and temporal differences in the associations between cardiovascular disease (CVD) and its classic risk factors are unknown. The current study examined these associations in different European regions over a 30-year period. METHODS The study sample comprised 553818 individuals from 49 cohorts in 11 European countries (baseline: 1982-2012) who were followed up for a maximum of 10 years
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Role of Ideal Cardiovascular Health Metrics in Reducing Risk of Incident Arrhythmias. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-15 Yun-Jiu Cheng,Hai Deng,Yi-Jian Liao,Xian-Hong Fang,Hong-Tao Liao,Fang-Zhou Liu,Qian He,Jin-Jie Wang,Shu-Lin Wu,Wei-Dong Lin,Yu-Mei Xue
AIMS Cardiovascular health (CVH) has been proved to reduce cardiovascular disease burden and mortality, but data are lacking regarding cardiac arrhythmias. The aim of this study was to assess the association between CVH metrics and atrial fibrillation/flutter (AF), ventricular arrhythmias and bradyarrhythmias. METHODS AND RESULTS This study analyzed data from the ARIC (Atherosclerosis Risk in Communities)
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SGLT2 inhibitors for the prevention of atrial fibrillation: a systemic review and meta-analysis. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-15 Hong-Da Zhang,Lei Ding,Li-Jie Mi,Ai-Kai Zhang,Kuo Zhang,Zi-Han Jiang,Feng-Yuan Yu,Xin-Xin Yan,Yu-Jing Shen,Min Tang
AIMS Sodium-glucose co-transporter-2 (SGLT2) inhibitors are reported to have cardiac benefits. The effects of SGLT2 inhibitors on the prevention of atrial fibrillation (AF) remain inconclusive. We aimed to investigate whether SGLT2 inhibitors can prevent AF occurrence in patients with cardiometabolic diseases. METHODS We searched MEDLINE, EMBASE, and the Cochrane CENTRAL database up to July 1, 2023
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Post-treatment level of LDL-C and all-cause mortality in patients with atherosclerotic cardiovascular disease: evidence from real-world setting. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-15 Fan Luo,Yuxin Lin,Xiaodong Zhang,Yanqin Li,Licong Su,Shiyu Zhou,Ruqi Xu,Qi Gao,Ruixuan Chen,Zhixin Guo,Sheng Nie,Xin Xu,
AIMS This study aimed to evaluate the safety of currently recommended target of LDL-C control on mortality in patients with atherosclerotic cardiovascular disease (ASCVD). METHODS Using deidentified electronic health record data, we conducted a multicenter retrospective cohort study involving individuals with documented ASCVD who had received statin treatment for at least 3 months across China. The
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Gender Disparities in Cardiovascular Lifetime Risk - don't forget myocardial infarction in men. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-13 Eva Prescott
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Mediterranean diet and epicardial adipose tissue in patients with atrial fibrillation treated with ablation: a substudy of the "PREDIMAR" trial. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-10 María Teresa Barrio-Lopez,Miguel Ruiz-Canela,Leticia Goni Mateos,Almudena Martinez Valiente,Silvia Romero Garcia,Víctor de la O,Belen Diaz Anton,Leticia Fernandez-Friera,Eduardo Castellanos,Miguel Angel Martínez-González,Jesus Almendral
AIMS To analyze the relationship between Mediterranean Diet (MedDiet) adherence and epicardial adipose tissue (EAT) in patients with atrial fibrillation (AF) and the association between EAT or MedDiet adherence at baseline with AF recurrence after ablation. METHODS We included 199 patients from the PREDIMAR trial (PREvención con DIeta Mediterránea de Arritmias Recurrentes), in a single Center in this
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Erratum to: Dysregulation of ventilation at day and night time in heart failure. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-09
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Associations Between Occupational Physical Activity and Left Ventricular Structure and Function Over 25 Years in CARDIA. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-09 Tyler D Quinn,Abbi Lane,Kelley Pettee Gabriel,Barbara Sternfeld,David R Jacobs,Peter Smith,Bethany Barone Gibbs
AIMS Leisure-time physical activity (LTPA) confers cardiovascular health benefits, while occupational physical activity (OPA) may have paradoxically negative health associations. This study tested the explanatory hypothesis that unfavorable cardiac remodeling may result from chronic OPA-induced cardiovascular strain. METHODS Longitudinal associations of OPA and left ventricular (LV) structure and function
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Editorial comments: focus on population science. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-09 Andrea Attanasio,Massimo F Piepoli
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Habits and heartbeats: learning from historical longitudinal data on primary prevention of atrial fibrillation. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-09 Orly Sapir,Francisco Lopez-Jimenez,Gal Tsaban
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Fast food trucks near your doorstep are not good for your heart. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-09 Maja-Lisa Løchen
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Cost-effectiveness and diagnostic accuracy of focused cardiac ultrasound in the pre-participation screening of athletes: the SPORT-FoCUS study. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-09 Geza Halasz,Bruno Capelli,Alessia Nardecchia,Mattia Cattaneo,Tiziano Cassina,Vincenzo Biasini,Davide Barbieri,Michele Villa,Matteo Beltrami,Francesco Perone,Matteo Villani,Matteo Badini,Federico Gervasi,Massimo Piepoli,Gabriele Via
AIMS The role of pre-participation screening (PPS) modalities in preventing sudden cardiac death (SCD) in athletes is debated due to a high false-positive rate. Focused cardiac ultrasound (FoCUS) has shown higher sensitivity and specificity, but its cost-effectiveness remains uncertain. This study aimed to determine the diagnostic performance and cost-effectiveness of FoCUS use in PPS. METHODS AND
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Why should ascending aorta dimension be measured and how should it be normalized in hypertensive patients? Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-09 Norbert J Guettler
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Associations between the neighbourhood food environment and cardiovascular disease: a systematic review. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-09 Paul Meijer,Hidser Numans,Jeroen Lakerveld
AIMS To systematically review the current evidence on the association between the neighbourhood food environment and cardiovascular disease (CVD) in adults. METHODS AND RESULTS We searched the literature databases CINAHL, MEDLINE, and EMBASE for studies published between 1 January 2000 and 1 May 2022. Studies focusing on the indoor home, workplace, or school food environment were excluded. Two independent
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Inflammation and cardiovascular disease: new epidemiologic data and their potential implications for anti-cytokine therapy. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-09 Wolfgang Koenig,Hendrik B Sager
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Polypill-based strategy vs. usual care for secondary prevention of cardiovascular disease: a meta-analysis of randomized controlled trials. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-09 André Rivera,Bruno Campos,Stephanie Ceolin,Amanda Godoi,Everton Castanha,Carlos Alberto Campello Jorge,Rhanderson Cardoso
AIMS We aimed to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) to determine the impact of a polypill-based strategy (PBS) on therapeutic adherence and cardiovascular outcomes compared with usual care for secondary prevention of cardiovascular diseases (CVDs). METHODS AND RESULTS We systematically searched PubMed, Cochrane, and Scopus databases from inception to
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The built environment and cardiovascular disease: an umbrella review and meta-meta-analysis. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-09 Mingwei Liu,Paul Meijer,Thao Minh Lam,Erik J Timmermans,Diederick E Grobbee,Joline W J Beulens,Ilonca Vaartjes,Jeroen Lakerveld
AIMS To provide a comprehensive overview of the current evidence on objectively measured neighbourhood built environment exposures in relation to cardiovascular disease (CVD) events in adults. METHODS AND RESULTS We searched seven databases for systematic reviews on associations between objectively measured long-term built environmental exposures, covering at least one domain (i.e. outdoor air pollution
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Hypothetical interventions and risk of atrial fibrillation by sex and education: application of the parametric g-formula in the Tromsø Study. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-09 Linn Nilsen,Ekaterina Sharashova,Maja-Lisa Løchen,Goodarz Danaei,Tom Wilsgaard
AIMS To use the parametric g-formula to estimate the long-term risk of atrial fibrillation (AF) by sex and education under hypothetical interventions on six modifiable risk factors. METHODS AND RESULTS We estimated the risk reduction under hypothetical risk reduction strategies for smoking, physical activity, alcohol intake, body mass index, systolic, and diastolic blood pressure in 14 923 women and
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Validation of the European SCORE2 Models in a Canadian Primary Care Cohort. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-08 Maneesh Sud,Atul Sivaswamy,Peter C Austin,Husam Abdel-Qadir,Todd J Anderson,Rohan Khera,David M J Naimark,Douglas S Lee,Idan Roifman,George Thanassoulis,Karen Tu,Harindra C Wijeysundera,Dennis T Ko
INTRODUCTION SCORE2 was recently developed to predict atherosclerotic cardiovascular disease (ASCVD) in Europe. Whether these models could be used outside of Europe is not known. The objective of this study was to test the validity of SCORE2 in a large Canadian cohort. METHODS A primary care cohort of persons with routinely collected electronic medical record data from January 1, 2010, to December
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Cardiac rehabilitation participation within 6 months of discharge in 37 136 myocardial infarction survivors: a nationwide registry study. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-07 T M Norekvål,M Bale,H K Bedane,T Hole,C B Ingul,J Munkhaugen
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The Oral-Systemic Axis: How Oral Health Affects Cardiovascular and Metabolic Health. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-07 Elisabeth Mauri-Obradors,Roberto Elosua
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Artificial Intelligence ECG as a Novel Screening Tool to Detect a Newly Abnormal Left Ventricular Ejection Fraction After Anthracycline-Based Cancer Therapy. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-07 Johanna E J Jacobs,Grace Greason,Kathryn E Mangold,Hans Wildiers,Rik Willems,Stefan Janssens,Peter Noseworthy,Francisco Lopez-Jimenez,Jens-Uwe Voigt,Paul Friedman,Lucas Van Aelst,Bert Vandenberk,Zachi Itzhak Attia,Joerg Herrmann
AIM Cardiotoxicity is a serious side effect of anthracycline treatment, most commonly manifesting as a reduction in left ventricular ejection fraction (LVEF). Early recognition and treatment have been advocated, but robust, convenient and cost-effective alternatives to cardiac imaging are missing. Recent developments in artificial intelligence (AI) techniques applied to electrocardiograms (ECGs) may
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The Rough but Fascinating Road to Estimate Peak Exercise Oxygen Uptake by Resting ECG-Based Deep Learning. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-07 Marco Guazzi,Violetta Serrantoni
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Reliability, validity and utility of tests and scores. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-06 Andreas Hoffmann
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SuRAR Levels: Underscoring the Link Between Low Educational Attainment and Death Among Coronary Artery Disease Patients. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-06 Otávio R Coelho-Filho,Raul D Santos
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Metabolic disorders mediate the relation of miscarriage with cardiovascular diseases. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-06 Fang Zhu,Danielle Noordenmeer,Elif Aribas,Maxime Bos,Eric Boersma,Maryam Kavousi
AIMS The extent to which the contribution of pregnancy loss to cardiovascular diseases can be explained by metabolic disorders is poorly elucidated but holds insights for reducing long-term cardiovascular risk. To investigate the mediating effects of hypertension, diabetes mellitus (DM), and lipoprotein metabolism disorders on the association of miscarriage and stillbirth with coronary heart disease
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Blood pressure, hypertension and the risk of heart failure: A systematic review and meta-analysis of cohort studies. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-06 Priscilla Kyei Baffour,Leila Jahangiry,Shalu Jain,Abhijit Sen,Dagfinn Aune
BACKGROUND Several observational studies have investigated the association between hypertension or elevated systolic blood pressure and diastolic blood pressure and risk of heart failure, but not all the studies have been consistent. This systematic review and meta-analysis aimed to summarize the available data from cohort studies on the association between hypertension, systolic and diastolic blood
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Oxidative stress-related genetic variation and antioxidant vitamin intake in intact and ruptured abdominal aortic aneurysm: Does sex matter? Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-01 Til Bahadur Basnet,Bharat Khatri
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Health and the Environment: Messages for the Cardiologist. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-11-01 P M Mannucci
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When the ovaries speak to your heart…..are we ready to listen? Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-31 Serenella Castelvecchio,Rossella E Nappi
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Protecting women heart in type 2 diabetes mellitus: why, how and when? Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-28 Mitja Lainscak,Cornelia Margineanu,Ovidiu Chioncel,Giuseppe M C Rosano
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What about chronotropic incompetence in heart failure with mildly reduced ejection fraction? Clinical and prognostic implications from the MECKI score data-set. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-27 Damiano Magrì,Giovanna Gallo,Massimo Piepoli,Elisabetta Salvioni,Massimo Mapelli,Carlo Vignati,Emiliano Fiori,Melwyn Luis Muthukkattil,Ugo Corrà,Marco Me Tra,Stefania Paolillo,Pasquale Perrone Filardi,Antonello Maruotti,Pierfrancesco Alaimo Di Loro,Michele Senni,Rocco Lagioia,Domenico Scrutinio,Michele Emdin,Claudio Passino,Gianfranco Parati,Gianfranco Sinagra,Michele Correale,Roberto Badagliacca,Susanna
AIMS Chronotropic incompetence (CI) is a strong predictor of outcome in heart failure with reduced ejection fraction (HFrEF), however no data on its clinical and prognostic impact in heart failure with mildly reduced ejection fraction (HFmrEF). Therefore, the study aims to investigate, in a large multicenter HFmrEF cohort, the prevalence of CI as well as its relationship with exercise capacity and
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Triglyceride-Glucose Index, LDL and Cardiovascular Outcomes in Chronic Stable Cardiovascular Disease: Results from the ONTARGET and TRANSCEND trials. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-27 Bernhard Haring,Helmut Schumacher,Giuseppe Mancia,Koon K Teo,Eva M Lonn,Felix Mahfoud,Roland Schmieder,Johannes F E Mann,Karen Sliwa,Salim Yusuf,Michael Böhm
BACKGROUND The triglyceride-glucose (TyG) index has been proposed as an alternative to insulin resistance and as a predictor of cardiovascular outcomes. Little is known on its role in chronic stable cardiovascular disease and its predictive power at controlled low-density lipoprotein (LDL) levels. METHODS Our study population consisted of 29,960 participants in the ONTARGET and TRANSCEND trials that
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Shared Decision Making in young elite and professional athletes: pros and pitfalls. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-26 Antonio Pelliccia,Kathryn Larson
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Are Body Mass Index Changes Related to Incident Atrial Fibrillation? - Results of the Danish Diet, Cancer, and Health Cohort. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-26 Betsy J Medina-Inojosa,Francisco Lopez-Jimenez
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Improving risk stratification in people with previous manifestations of cardiovascular disease: one size does not fit all in secondary prevention. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-26 Marcio H Miname,Raul D Santos
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Editorial comments: focus on cardiovascular risk burden. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-26 Andrea Attanasio,Massimo F Piepoli
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Lifestyle patterns, genetic susceptibility, and risk of valvular heart disease: a prospective cohort study based on the UK Biobank. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-26 Chenglin Jia,Yu Zeng,Xuan Huang,Huazhen Yang,Yuanyuan Qu,Yao Hu,Wenwen Chen,Xiaoyan Yang
AIMS Genetic and lifestyle factors are both major contributors to valvular heart disease (VHD). However, it is still uncertain whether genetic susceptibility alters the association between lifestyle and VHD. We aimed to investigate the association between lifestyle and VHD in different genetic risk backgrounds. METHODS AND RESULTS A prospective cohort study was carried out on 499 341 participants without
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Smoking threats beyond being a smoker: a burden on children and adolescents' healthy living. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-20 Vicente Artola Arita,Silvia Juliana Trujillo-Cáceres,Marilyne Menassa
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The Effect of Fibrates on Lowering Low-Density Lipoprotein Cholesterol and Cardiovascular Risk Reduction: A Systemic Review and Meta-analysis. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-19 Kyung An Kim,Na Jin Kim,Eun-Ho Choo
AIMS The effect of fibrate treatment on cardiovascular risk is inconsistent. This meta-analysis aimed to assess the effect of fibrates on major adverse cardiovascular outcome (MACE) reduction. METHODS PubMed, Embase, and Cochrane library databases were searched up to February 2023 for randomized controlled trials comparing fibrate therapy against placebo and reporting cardiovascular outcomes and lipid
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Evolocumab in paediatric heterozygous familial hypercholesterolaemia: cognitive function during 80 weeks of open-label extension treatment. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-19 Raul D Santos,Andrea Ruzza,Bei Wang,Paul Maruff,Adrian Schembri,Ajay K Bhatia,François Mach,Jean Bergeron,Isabelle Gaudet,Julie St Pierre,John J P Kastelein,G Kees Hovingh,Albert Wiegman,Daniel Gaudet,Frederick J Raal
AIMS PCSK9 inhibition intensively lowers low-density lipoprotein cholesterol and is well tolerated in adults and paediatric patients with familial hypercholesterolaemia (FH). HAUSER-RCT showed that 24 weeks of treatment with evolocumab in paediatric patients did not affect cognitive function. This study determined the effects of 80 additional weeks of evolocumab treatment on cognitive function in paediatric
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Impact of hypertriglyceridaemia on cardiovascular mortality according to low-density lipoprotein cholesterol in a 15.6-million population. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-18 Hyung-Bok Park,Reza Arsanjani,Sung-Jin Hong,Jee-Jeon Yi,Sang-Wook Yi
AIMS To assess the association between triglyceride (TG) levels and cardiovascular disease (CVD) mortality concerning low-density lipoprotein cholesterol (LDL-C) and age in the general population. METHODS AND RESULTS From the Korean National Health Insurance Service database, 15,672,028 participants aged 18-99 who underwent routine health examinations were followed up for CVD mortality. Hazard ratios
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Activities of daily living in heart failure patients and healthy subjects: when the cardiopulmonary assessment goes beyond traditional exercise test protocols. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-11 Massimo Mapelli,Elisabetta Salvioni,Irene Mattavelli,Paola Gugliandolo,Alice Bonomi,Pietro Palermo,Maddalena Rossi,Davide Stolfo,Finn Gustafsson,Massimo Piepoli,Piergiuseppe Agostoni
Heart failure (HF) patients traditionally report dyspnoea as their main symptom. Although the cardiopulmonary exercise test (CPET) and 6 min walking test are the standardized tools in assessing functional capacity, neither cycle ergometers nor treadmill maximal efforts do fully represent the actual HF patients' everyday activities [activities of daily living (ADLs)] (i.e. climbing the stairs). New-generation
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The alveolar-capillary unit in the physiopathological conditions of heart failure: identification of a potential marker. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-11 Cristina Banfi,Paola Gugliandolo,Stefania Paolillo,Alice Mallia,Erica Gianazza,Piergiuseppe Agostoni
In this review, we describe the structure and function of the alveolar-capillary membrane and the identification of a novel potential marker of its integrity in the context of heart failure (HF). The alveolar-capillary membrane is indeed a crucial structure for the maintenance of the lung parenchyma gas exchange capacity, and the occurrence of pathological conditions determining lung fluids accumulation
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Exercise oscillatory ventilation: the past, present, and future. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-11 Gonçalo Cunha,Anna Apostolo,Fabiana De Martino,Elisabetta Salvioni,Irene Matavelli,Piergiuseppe Agostoni
Exercise oscillatory ventilation (EOV) is a fascinating event that can be appreciated in the cardiopulmonary exercise test and is characterized by a cyclic fluctuation of minute ventilation, tidal volume, oxygen uptake, carbon dioxide production, and end-tidal pressure for oxygen and carbon dioxide. Its mechanisms stem from a dysregulation of the normal control feedback of ventilation involving one
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The cardiopulmonary exercise test in the prognostic evaluation of patients with heart failure and cardiomyopathies: the long history of making a one-size-fits-all suit. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-11 Elisabetta Salvioni,Alice Bonomi,Damiano Magrì,Marco Merlo,Beatrice Pezzuto,Mattia Chiesa,Massimo Mapelli,Nikita Baracchini,Gianfranco Sinagra,Massimo Piepoli,Piergiuseppe Agostoni
Cardiopulmonary exercise test (CPET) has become pivotal in the functional evaluation of patients with chronic heart failure (HF), supplying a holistic evaluation both in terms of exercise impairment degree and possible underlying mechanisms. Conversely, there is growing interest in investigating possible multiparametric approaches in order to improve the overall HF risk stratification. In such a context
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Dysregulation of ventilation at day and night time in heart failure. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-11 Mauro Contini,Massimo Mapelli,Cosimo Carriere,Paola Gugliandolo,Andrea Aliverti,Massimo Piepoli,Alessandra Angelucci,Nikita Baracchini,Maria Teresa Capovilla,Piergiuseppe Agostoni
Heart failure (HF) is characterized by an increase in ventilatory response to exercise of multifactorial aetiology and by a dysregulation in the ventilatory control during sleep with the occurrence of both central and obstructive apnoeas. In this setting, the study of the ventilatory behaviour during exercise, by cardiopulmonary exercise testing, or during sleep, by complete polysomnography or simplified
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Beyond VO2: the complex cardiopulmonary exercise test. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-11 Irene Mattavelli,Carlo Vignati,Stefania Farina,Anna Apostolo,Gaia Cattadori,Fabiana De Martino,Beatrice Pezzuto,Denise Zaffalon,Piergiuseppe Agostoni
Cardiopulmonary exercise test (CPET) is a valuable diagnostic tool with a specific application in heart failure (HF) thanks to the strong prognostic value of its parameters. The most important value provided by CPET is the peak oxygen uptake (peak VO2), the maximum rate of oxygen consumption attainable during physical exertion. According to the Fick principle, VO2 equals cardiac output (Qc) times the
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Physiology of exercise and heart failure treatments: cardiopulmonary exercise testing as a tool for choosing the optimal therapeutic strategy. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-11 Jeness Campodonico,Mauro Contini,Marina Alimento,Massimo Mapelli,Elisabetta Salvioni,Irene Mattavelli,Alice Bonomi,Piergiuseppe Agostoni
In the last decades, the pharmacological treatment of heart failure (HF) become more complex due to the availability of new highly effective drugs. Although the cardiovascular effects of HF therapies have been extensively described, less known are their effects on cardiopulmonary function considered as a whole, both at rest and in response to exercise. This is a 'holistic' approach to disease treatment
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Determinants of exercise performance in heart failure patients with extremely reduced cardiac output and left ventricular assist device. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-11 Anna Apostolo,Carlo Vignati,Marco Cittar,Nikita Baracchini,Saima Mushtaq,Gaia Cattadori,Susanna Sciomer,Filippo Trombara,Massimo Piepoli,Piergiuseppe Agostoni
The evaluation of exercise capacity and cardiac output (QC) is fundamental in the management of patients with advanced heart failure (AdHF). QC and peak oxygen uptake (VO2) have a pivotal role in the prognostic stratification and in the definition of therapeutic interventions, including medical therapies and devices, but also specific treatments such as heart transplantation and left ventricular assist
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Exercise in hypoxia: a model from laboratory to on-field studies. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-11 Carlo Vignati,Mauro Contini,Elisabetta Salvioni,Carolina Lombardi,Sergio Caravita,Grzegorz Bilo,Erik R Swenson,Gianfranco Parati,Piergiuseppe Agostoni
Clinical outcome and quality of life of patients with chronic heart failure (HF) have greatly improved over the last two decades. These results and the availability of modern lifts allow many cardiac patients to spend leisure time at altitude. Heart failure per se does not impede a safe stay at altitude, but exercise at both simulated and real altitudes is associated with a reduction in performance
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Editorial comments: focus on metabolic disorders. Eur. Assoc. Prev. Cardiol. (IF 8.3) Pub Date : 2023-10-10 Andrea Attanasio,Massimo F Piepoli