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  • Left atrial appendage thrombosis in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation
    Can. J. Cardiol. (IF 5.592) Pub Date : 2020-05-23
    Georg Stachel; Felix J. Woitek; Lisa Crusius; Stephan Haussig; Philipp Kiefer; Sergey Leontyev; Florian Schlotter; Aileen Spindler; Robert Höllriegel; Jennifer Hommel;; Michael A. Borger; Holger Thiele; David Holzhey; Axel Linke; Norman Mangner

    Background Data about the impact of left atrial appendage thrombosis (LAAT) on early safety and mortality in patients undergoing transfemoral transcatheter aortic valve implantation (TF-TAVI) are scarce. We aimed to investigate the incidence and predictors of LAAT and the outcome associated with this condition in patients treated by TF-TAVI. Methods Retrospective data analysis derived from a prospective

  • Colchicine Use and Incident Coronary Artery Disease in Male Patients with Gout
    Can. J. Cardiol. (IF 5.592) Pub Date : 2020-05-23
    Binita Shah; Michael Toprover; Daria B. Crittenden; Susanna Jeurling; V. Courtney Pike; Svetlana Krasnokutsky; Yuhe Xia; Mark C. Fisher; Anastasia Slobodnick; Craig T. Tenner; Stuart D. Katz; Michael H. Pillinger

    Background Inflammation is associated with coronary artery disease (CAD) and myocardial infarction (MI). Patients with gout are at increased risk of MI, and colchicine is associated with a reduced risk of MI. The objective of this study was to determine whether colchicine prevents incident development of CAD in patients with gout. Methods This retrospective study followed a cohort of male gout patients

  • Decrease and Delay in Hospitalization for Acute Coronary Syndromes during the 2020 SARS-CoV-2 Pandemic.
    Can. J. Cardiol. (IF 5.592) Pub Date : 2020-05-22
    Gioel Gabrio Secco,Chiara Zocchi,Rosario Parisi,Annalisa Roveta,Francesca Mirabella,Matteo Vercellino,Gianfranco Pistis,Maurizio Reale,Silvia Maggio,Andrea Audo,Daniela Kozel,Giacomo Centini,Antonio Maconi,Carlo Di Mario

    The diffusion of SARS-CoV-2 forced the Italian population to restrictive measures that modified the patients' response to non-SARS-CoV-2 medical conditions. We evaluated all ACS-patients admitted in three high-volume hospitals during the first month of SARS-CoV-2 Italian-outbreak and compared them to ACS-patients admitted during the same period 1-year before. Hospitalization for ACS decreased from

  • Identifying Guideline-Practice Gaps to Optimize Evaluation and Management for Patients with Syncope.
    Can. J. Cardiol. (IF 5.592) Pub Date : 2020-05-22
    Susan Smyth,Vedant Gupta,Mark Williams,Amy Cowley,Matthew Sirrine,Hilary Surratt,Romil Chadha,Seth Stearley,Vikas Bhalla,Jing Li

    Syncope is a common and complex symptom that requires efficient evaluation to determine the etiology. Recent guidelines focus on high-value testing, but a systematic evaluation of their implementation has not been performed. To this end, we used a mixed methods approach of surveys, chart reviews and focus groups to understand current practices relating to the diagnosis and management of patients with

  • Diagnostic CMR Imaging Criteria in Noncompaction Cardiomyopathy and the Yield of Genetic Testing.
    Can. J. Cardiol. (IF 5.592) Pub Date : 2020-05-21
    Jaap I van Waning,Kadir Caliskan,Raluca G Chelu,Nikki van der Velde,Andrea Pezzato,Michelle Michels,Marjon A van Slegtenhorst,Eric Boersma,Koen Nieman,Danielle Majoor-Krakauer,Alexander Hirsch

    BACKGROUND Noncompaction cardiomyopathy (NCCM) is characterized by a thickened myocardial wall with excessive trabeculations of the left ventricle and around 30% is explained by a (likely) pathogenic variant ((L)PV) in a cardiomyopathy gene. Diagnosing a (L)PV is important because it allows to identify accurately which relatives are at risk and helps predicting prognosis. The goal of the study was

  • The Use of Decision Modelling to Inform Timely Policy Decisions on Cardiac Resource Capacity during the COVID-19 Pandemic.
    Can. J. Cardiol. (IF 5.592) Pub Date : 2020-05-21
    Derrick Y Tam,David Naimark,Madhu K Natarajan,Graham Woodward,Garth Oakes,Mirna Rahal,Kali Barrett,Yasin A Khan,Raphael Ximenes,Stephen Mac MBiotech,Beate Sander,Harindra C Wijeysundera

    In Ontario, on March 16th, 2020, a directive was issued to all acute care hospitals to halt non-essential procedures in anticipation for a potential surge in COVID-19 patients. This included scheduled outpatient cardiac surgical and interventional procedures that required the use of intensive care units, ventilators, and skilled critical care personnel, given that these procedures would draw from the

  • Lung Ultrasound for Cardiologists in the Time of COVID-19.
    Can. J. Cardiol. (IF 5.592) Pub Date : 2020-05-13
    Omid Kiamanesh,Lea Harper,Katie Wiskar,Warren Luksun,Michael McDonald,Heather Ross,Anna Woo,John Granton

    Lung ultrasound (LUS) is a point-of-care ultrasound (POCUS) technique used for its portability, widespread availability, and ability to provide real-time diagnostic information procedural guidance. LUS outperforms lung auscultation and chest X-ray, and is an alternative to chest computed tomography in select cases. Cardiologists may enhance their physical and echocardiographic examination with the

  • SYNCOPE IN PATIENTS WITH SEVERE AORTIC STENOSIS: More than only an obstructive issue.
    Can. J. Cardiol. (IF 5.592) Pub Date : 2020-05-18
    Jaume Francisco-Pascual,Eduard Rodenas-Alesina,Yassin Belahnech-Pujol,Nuria Rivas-Gándara,Jordi Pérez-Rodon,Alba Santos-Ortega,Begoña Benito,Ivo Roca-Luque,Yolima Cossio-Gil,Vicens Serra Garcia,Sandra Llerena-Bruton,Julian Rodríguez-García,Angel Moya-Mitjans,David García-Dorado,Ignacio Ferreira-González

    BACKGROUND Severe aortic stenosis (AoS) is considered a primary cause of syncope. However, other mechanisms may be present in these patients and accurate diagnosis can have important clinical implications. The aim of this study is to assess the different etiologies of syncope in patients with severe AoS and the impact of attaining a certain or highly probable diagnosis for the syncope on prognosis

  • Cyclin dependent kinase inhibitor-2b controls fibrosis and functional changes in ischemia-induced heart failure via the BMI1-p15-Rb signaling pathway.
    Can. J. Cardiol. (IF 5.592) Pub Date : 2020-05-16
    Wenbo Yang,Andi Zhang,Yanxin Han,Xiuxiu Su,Yanjia Chen,Weilin Zhao,Ke Yang,Wei Jin

    BACKGROUND Cardiac fibrosis is an important cause of heart failure(HF) after myocardial infarction(MI). The cyclin dependent kinase inhibitor 2b(CDKN2b) regulates the cell cycle by encoding the p15 protein and participates in the development of various tumors. However, the role of CDKN2b/p15 in cardiac fibrosis and HF after MI remains unclear. METHODS Lentivirus was used to induce the silence and overexpression