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Correction to: Timing of Cardiac Surgical Interventions and Postoperative Mortality in Children With Severe Congenital Heart Defects Across Europe: Data From the EUROlinkCAT Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-18
In the article by Mads Damkjær et al, “Timing of Cardiac Surgical Interventions and Postoperative Mortality in Children With Severe Congenital Heart Defects Across Europe: Data From the EUROlinkCAT Study,” which published online December 18, 2023 (J Am Heart Assoc. 2023;12:e029871. DOI: 10.1161/JAHA.122.029871) and was included in the December 19, 2023 issue of the journal, a correction was needed
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Adverse Effects of Aldosterone: Beyond Blood Pressure J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-18 Jenifer M. Brown
Aldosterone is a steroid hormone that primarily acts through activation of the mineralocorticoid receptor (MR), a nuclear receptor responsible for downstream genomic regulation. Classically, activation of the MR in the renal tubular epithelium is responsible for sodium retention and volume expansion, raising systemic blood pressure. However, activation of the MR across a wide distribution of tissue
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Circulating Branched Chain Amino Acids and Cardiometabolic Disease J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-18 Keenan S. Fine, John T. Wilkins, Konrad T. Sawicki
Branched chain amino acids (BCAAs) are essential for protein homeostasis, energy balance, and signaling pathways. Changes in BCAA homeostasis have emerged as pivotal contributors in the pathophysiology of several cardiometabolic diseases, including type 2 diabetes, obesity, hypertension, atherosclerotic cardiovascular disease, and heart failure. In this review, we provide a detailed overview of BCAA
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Predicting High‐Risk Fetal Cardiac Disease Anticipated to Need Immediate Postnatal Stabilization and Intervention with Planned Pediatric Cardiac Operating Room Delivery J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-18 Amol Moray, Proscovia M. Mugaba, Chloe Joynt, Angela McBrien, Luke G. Eckersley, Ernest Phillipos, Paula Holinski, Lindsay Ryerson, James Yashu Coe, Sujata Chandra, Billy Wong, Michele Derbyshire, Maria Lefebvre, Mohammed Al Aklabi, Lisa K. Hornberger
BackgroundDistances between delivery and cardiac services can make the care of fetuses with cardiac disease at risk of acute cardiorespiratory instability at birth a challenge. In 2013 we implemented a fetal echocardiography‐based algorithm targeting fetuses considered high risk for acute cardiorespiratory instability at ≤2 hours of birth for delivery in our pediatric cardiac operating room of our
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Long‐Term Survival After Single‐Ventricle Palliation: A Swedish Nationwide Cohort Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-18 Magnus Dalén, Michal Odermarsky, Petru Liuba, Jens Johansson Ramgren, Mats Synnergren, Jan Sunnegårdh
BackgroundLong‐term survival after single‐ventricle palliation and the effect of dominant ventricle morphology in large, unselected series of patients are scarcely reported.Methods and ResultsThis nationwide cohort study included all children undergoing operation with single‐ventricle palliation during their first year of life in Sweden between January 1994 and December 2019. Data were obtained from
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Iron Status and Risk of Heart Disease, Stroke, and Diabetes: A Mendelian Randomization Study in European Adults J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-18 Yunan Liu, Robert Clarke, Derrick A. Bennett, Geng Zong, Wei Gan
BackgroundThe relevance of iron status biomarkers for coronary artery disease (CAD), heart failure (HF), ischemic stroke (IS), and type 2 diabetes (T2D) is uncertain. We compared the observational and Mendelian randomization (MR) analyses of iron status biomarkers and hemoglobin with these diseases.Methods and ResultsObservational analyses of hemoglobin were compared with genetically predicted hemoglobin
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Accumulating Sedentary Time and Physical Activity From Childhood to Adolescence and Cardiac Function in Adolescence J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-18 Eero A. Haapala, Marja H. Leppänen, Earric Lee, Kai Savonen, Jari A. Laukkanen, Mika Kähönen, Soren Brage, Timo A. Lakka
BackgroundIncreased physical activity (PA) may mitigate the negative cardiovascular health effects of sedentary behavior in adolescents. However, the relationship of PA and sedentary time from childhood with cardiac function in adolescence remains underexplored. Therefore, we investigated the associations of cumulative sedentary time and PA from childhood to adolescence with cardiac function in adolescence
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CircALMS1 Alleviates Pulmonary Microvascular Endothelial Cell Dysfunction in Pulmonary Hypertension J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-18 Xiaoyi Hu, Yuanyuan Sun, Shang Wang, Hui Zhao, Yaqin Wei, Jiaqi Fu, Yuxia Huang, Wenhui Wu, Jinling Li, Jinming Liu, Sugang Gong, Qinhua Zhao, Lan Wang, Rong Jiang, Xiao Song, Ping Yuan
BackgroundCircular RNAs can serve as regulators influencing the development of pulmonary hypertension (PH). However, their function in pulmonary vascular intimal injury remains undefined. Thus, we aimed to identify specifically expressed circular RNAs in pulmonary microvascular endothelial cells (PMECs) under hypoxia and PH.Methods and ResultsDeep RNA sequencing and quantitative real‐time polymerase
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Associations of Circulating Vascular Cell Adhesion Molecule‐1 and Intercellular Adhesion Molecule‐1 With Long‐Term Cardiac Function J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-18 Daniel T. Mathew, Graham Peigh, Joao A.C. Lima, Suzette J. Bielinski, Nicholas B. Larson, Matthew A. Allison, Sanjiv J. Shah, Ravi B. Patel
BackgroundAlthough VCAM‐1 (vascular cell adhesion molecule‐1) and ICAM‐1 (intercellular adhesion molecule‐1) have been associated with incident heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF), the associations of VCAM‐1 and ICAM‐1 with sensitive measures of cardiac structure/function are unclear. The objective of this study is to evaluate associations between VCAM‐1
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Impaired Relaxation in Induced Pluripotent Stem Cell‐Derived Cardiomyocytes with Pathogenic TNNI3 Mutation of Pediatric Restrictive Cardiomyopathy J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-18 Renjie Wang, Moyu Hasegawa, Hidehiro Suginobe, Chika Yoshihara, Yoichiro Ishii, Atsuko Ueyama, Kazutoshi Ueda, Kazuhisa Hashimoto, Masaki Hirose, Ryo Ishii, Jun Narita, Takuji Watanabe, Takuji Kawamura, Masaki Taira, Takayoshi Ueno, Shigeru Miyagawa, Hidekazu Ishida
BackgroundRestrictive cardiomyopathy (RCM) is characterized by impaired diastolic function with preserved ventricular contraction. Several pathogenic variants in sarcomere genes, including TNNI3, are reported to cause Ca2+ hypersensitivity in cardiomyocytes in overexpression models; however, the pathophysiology of induced pluripotent stem cell (iPSC)‐derived cardiomyocytes specific to a patient with
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Application of Dual‐Layer Spectral‐Detector Computed Tomography Angiography in Identifying Symptomatic Carotid Atherosclerosis: A Prospective Observational Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-18 Jia Zhang, Sijia Li, Lei Wu, Haoyuan Wang, Chuanying Wang, Yinan Zhou, Binbin Sui, Xingquan Zhao
BackgroundDual‐layer spectral‐detector dual‐energy computed tomography angiography (DLCTA) can distinguish components of carotid plaques. Data on identifying symptomatic carotid plaques in patients using DLCTA are not available.Methods and ResultsIn this prospective observational study, patients with carotid plaques were enrolled and received DLCTA. The attenuation for both polyenergetic image and
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Prognostic Implications of Left Atrial Strain in Bicuspid Aortic Valve With Chronic Aortic Regurgitation J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-18 YuTing Tan, YuMan Li, WenHui Deng, RuiZe Zhang, RuoHan Zhao, Abudukadier Abulipizi, Jing Zhang, Xiang Ji, QuanFei Hou, Tianshu Liu, Lingyun Fang, Li Zhang, MingXing Xie, Jing Wang
BackgroundLeft atrial reservoir strain (LARS) is a novel imaging biomarker of left ventricular diastolic dysfunction. This study aimed to examine the prognostic implications of LARS in patients with bicuspid aortic valve and significant (moderate‐severe to severe) aortic regurgitation.Methods and ResultsA total of 220 patients with bicuspid aortic valve and significant aortic regurgitation were prospectively
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Impact of Secondary Amenorrhea on Cardiovascular Disease Risk in Physically Active Women: A Systematic Review and Meta‐Analysis J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-18 Nicole L. Tegg, Caitlynd Myburgh, Emma O'Donnell, Megan Kennedy, Colleen M. Norris
BackgroundExercise‐associated secondary amenorrhea results in estrogen deficiency, which may lead to dysfunction in estrogen's normal cardioprotective pathways. Estrogen may be essential in a woman's endothelial adaptations to exercise. The objective of this review was to assess the association between secondary amenorrhea in physically active women and cardiovascular disease (CVD) risk.Methods and
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Exercise‐Dependent Modulation of Immunological Response Pathways in Endurance Athletes With and Without Atrial Fibrillation J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-18 David Dorian, Dakota Gustafson, Ryan Quinn, Robert F. Bentley, Paul Dorian, Jack M. Goodman, Jason E. Fish, Kim A. Connelly
BackgroundAtrial fibrillation (AF) is a common arrhythmia characterized by uncoordinated atrial electrical activity. Lone AF occurs in the absence of traditional risk factors and is frequently observed in male endurance athletes, who face a 2‐ to 5‐fold higher risk of AF compared with healthy, moderately active males. Our understanding of how endurance exercise contributes to the pathophysiology of
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Incidence of Immune Checkpoint Inhibitor–Induced Myocarditis During the COVID‐19 Pandemic J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-18 Alexi Vasbinder, Elizabeth Anderson, Tonimarie Catalan, Anis Ismail, Mousumi Banerjee, Ian Pizzo, Kristen Machado, Pennelope Blakely, Joe‐Elie Salem, Salim S. Hayek
Immune checkpoint inhibitors (ICIs) have improved the survival of patients with various malignancies; however, they are associated with the development of myocarditis, an increasingly recognized immune‐related adverse event.1 Myocarditis has also entered the clinical spotlight due to the recent COVID‐19 pandemic given the increase in myocarditis cases associated with both SARS‐CoV‐2 infection and mRNA
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Potential Multidisciplinary Use of Large Language Models for Addressing Queries in Cardio‐Oncology J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-18 Pengfei Li, Xuejuan Zhang, Erjia Zhu, Shijun Yu, Bin Sheng, Yih Chung Tham, Tien Yin Wong, Hongwei Ji
In the crossroads of digital health and education, large language models (LLMs) emerge as tools with great potential.1 Trained on expansive textual data sets, these state‐of‐the‐art artificial intelligence models can generate multidisciplinary content, answer intricate queries, and accelerate information delivery.1 Particularly in the field of cardio‐oncology, which combines cardiac and oncological
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Recurrence After Atrial Fibrillation Ablation and Investigational Biomarkers of Cardiac Remodeling J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-12 Majd A. El‐Harasis, Joseph A. Quintana, J. Roberto Martinez‐Parachini, Gregory G. Jackson, Bibin T. Varghese, Zachary T. Yoneda, Brittany S. Murphy, Diane M. Crawford, Kelsey Tomasek, Yan Ru Su, Quinn S. Wells, Dan M. Roden, Gregory F. Michaud, Pablo Saavedra, Juan Carlos Estrada, Travis D. Richardson, Arvindh N. Kanagasundram, Sharon T. Shen, Jay A. Montgomery, Christopher R. Ellis, George H. Crossley
BackgroundRecurrence after atrial fibrillation (AF) ablation remains common. We evaluated the association between recurrence and levels of biomarkers of cardiac remodeling, and their ability to improve recurrence prediction when added to a clinical prediction model.Methods and ResultsBlood samples collected before de novo catheter ablation were analyzed. Levels of bone morphogenetic protein‐10, angiopoietin‐2
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Association of the Intensive Blood Pressure Target and Cardiovascular Outcomes in the Population With Chronic Kidney Disease: A Retrospective Study in Korea J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-12 Soo‐Young Yoon, Ji Yoon Kong, Su Jin Jeong, Jin Sug Kim, Hyeon Seok Hwang, Kyunghwan Jeong
BackgroundRecently, the target systolic blood pressure (BP) <120 mm Hg was suggested in the population with chronic kidney disease. We aimed to determine the applicability of intensified BP and to assess the incidence of cardiovascular disease (CVD) in the population with chronic kidney disease.Methods and ResultsParticipants who were >20 years old and had estimated glomerular filtration rate 15 to
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Tricuspid Regurgitation: A Review of Current Interventional Management J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-12 Maxwell Ambrosino, Matthew Sangoi, Nasser Monzer, Brett Irving, Paul Fiorilli, Benjamin Khazan, Sheldon Goldberg
ABSTRACTTricuspid regurgitation is a common yet clinically complex problem, traditionally managed with diuretic therapy with no observable mortality benefit. Older studies on surgical intervention observed poor outcomes; however, this clinical reasoning predates current surgical approaches and novel transcatheter technology. The tricuspid apparatus is a complex structure that poses a technical challenge
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Patient Risk–Benefit Preferences for Transcatheter Versus Surgical Mitral Valve Repair J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-12 Anna Hung, Jui‐Chen Yang, Matthew Wallace, Brittany A. Zwischenberger, Sreekanth Vemulapalli, Robert J. Mentz, Elizabeth Thoma, Scott Goates, John Lewis, Susan Strong, Shelby D. Reed
BackgroundTranscatheter edge‐to‐edge repair (TEER) of mitral regurgitation is less invasive than surgery but has greater 5‐year mortality and reintervention risks, and leads to smaller improvements in physical functioning. The study objective was to quantify patient preferences for risk–benefit trade‐offs associated with TEER and surgery.Methods and ResultsA discrete choice experiment survey was administered
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Technical Risk Stratification Nomogram Model for 90‐Day Mortality Prediction in Patients With Acute Basilar Artery Occlusion Undergoing Endovascular Thrombectomy: A Multicenter Cohort Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-12 Heng Ni, Linbo Zhao, Xinghua Ma, Penghua Lv, Yasuo Ding, Zhensheng Liu, Haibin Shi, Sheng Liu
BackgroundThis study aimed to establish and validate a nomogram model for predicting 90‐day mortality in patients with acute basilar artery occlusion receiving endovascular thrombectomy.Methods and ResultsA total of 242 patients with basilar artery occlusion undergoing endovascular thrombectomy were enrolled in our study, in which 172 patients from 3 stroke centers were assigned to the training cohort
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Influence of Preoperative COVID‐19 Vaccination on Outcomes After Coronary Artery Bypass Grafting—A Propensity Score–Matched Analysis J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-12 Hyoung Woo Chang, Soyeon Ahn, Jun Sung Kim, Hyun Jeong Han, You Kyeong Park, Kang Min Kim, Sang Yoon Kim, Joon Chul Jung, Jae Hang Lee, Dong Jung Kim, Cheong Lim, Kay‐Hyun Park
BackgroundReports of intravascular thrombosis and cardiac complications have raised concerns about the safety of COVID‐19 vaccinations, particularly in patients with high cardiovascular risk. Herein, we aimed to analyze the impact of preoperative COVID‐19 vaccination on outcomes after coronary artery bypass grafting (CABG).Methods and ResultsAmong 520 patients who underwent isolated CABG from 2020
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Sustained Pericarditis Recurrence Risk Reduction With Long‐Term Rilonacept J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-12 Massimo Imazio, Allan L. Klein, Antonio Brucato, Antonio Abbate, Michael Arad, Paul C. Cremer, Antonella Insalaco, Martin M. LeWinter, Basil S. Lewis, David Lin, Sushil A. Luis, Stephen J. Nicholls, Paul Sutej, Yishay Wasserstrum, JoAnn Clair, Indra Agarwal, Sheldon Wang, John F. Paolini, for the RHAPSODY Investigators
BackgroundRilonacept, a once‐weekly interleukin‐1 alpha and beta cytokine trap, reduced pericarditis recurrence in the phase 3 study, RHAPSODY (Rilonacept Inhibition of Interleukin‐1 Alpha and Beta for Recurrent Pericarditis: A Pivotal Symptomatology and Outcomes Study). The RHAPSODY long‐term extension further explored recurrent pericarditis natural history and treatment duration decision‐making during
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Antithrombotic Therapy in Cerebral Cavernous Malformations: A Systematic Review, Meta‐Analysis, and Network Meta‐Analysis J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-12 Basel Musmar, Hamza Salim, Jihad Abdelgadir, Samantha Spellicy, Nimer Adeeb, Ali Zomorodi, Allan Friedman, Issam Awad, Pascal M. Jabbour, David M. Hasan
BackgroundCerebral cavernous malformations are complex vascular anomalies in the central nervous system associated with a risk of intracranial hemorrhage. Traditional guidelines have been cautious about the use of antithrombotic therapy in this patient group, citing concerns about potential bleeding risk. However, recent research posits that antithrombotic therapy may actually be beneficial. This study
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Prognostic Utility of Society for Cardiovascular Angiography and Interventions Shock Stage Approach for Classifying Cardiogenic Shock Severity in Takotsubo Syndrome J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-12 Andrea Camblor‐Blasco, Ivan J. Nuñez‐Gil, Albert Duran Cambra, Manuel Almendro‐Delia, Eduard Ródenas‐Alesina, Clara Fernández‐Cordon, Oscar Vedia, Miguel Corbí‐Pascual, Emilia Blanco‐Ponce, Sergio Raposeiras‐Roubin, Marta Guillén Marzo, Alejandro Sanchez Grande Flecha, Jose Maria Garcia Acuña, Jorge Salamanca, Juan M. Escudier‐Villa, Agustin C. Martin‐Garcia, Marco Tomasino, Ravi Vazirani, Alberto
BackgroundCardiogenic shock (CS) is a significant complication of Takotsubo syndrome (TTS), contributing to heightened mortality and morbidity. Despite this, the Society for Cardiovascular Angiography and Interventions (SCAI) staging system for CS severity lacks validation in patients with TTS and CS. This study aimed to characterize a patient cohort with TTS using the SCAI staging system and assess
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Pentaspline Pulsed Field Ablation Catheter Versus Cryoballoon for Atrial Fibrillation Ablation: Results From a Prospective Comparative Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-12 Corentin Chaumont, Camilia Hayoun, Arnaud Savoure, Raphael Al Hamoud, Nathanael Auquier, Emily McDonnell, Helene Eltchaninoff, Frederic Anselme
BackgroundCryoballoon ablation is currently the gold standard technique for single‐shot pulmonary vein isolation (PVI). Pulsed field ablation (PFA) has recently emerged as an interesting nonthermal alternative energy for PVI. The purpose of our study was to evaluate the safety and long‐term efficacy of PVI using the pentaspline PFA catheter in comparison to cryoballoon ablation.Methods and ResultsBetween
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Mendelian Randomization Study With Clinical Follow‐Up Links Metabolites to Risk and Severity of Pulmonary Arterial Hypertension J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Elham Alhathli, Thomas Julian, Zain Ul Abideen Girach, A. A. Roger Thompson, Christopher Rhodes, Stefan Gräf, Niamh Errington, Martin R. Wilkins, Allan Lawrie, Dennis Wang, Johnathan Cooper‐Knock
BackgroundPulmonary arterial hypertension (PAH) exhibits phenotypic heterogeneity and variable response to therapy. The metabolome has been implicated in the pathogenesis of PAH, but previous works have lacked power to implicate specific metabolites. Mendelian randomization (MR) is a method for causal inference between exposures and outcomes.Methods and ResultsUsing genome‐wide association study summary
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Feasibility Value of Right Ventricular Longitudinal Shortening Fraction and the Prognostic Implications in Patients With Heart Transplantation J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Xiang Ji, Yiwei Zhang, Yuji Xie, Wenyuan Wang, Yuting Tan, Mingxing Xie, Li Zhang
BackgroundRight ventricular longitudinal shortening fraction (RVLSF) is a 2‐dimensional speckle tracking echocardiography parameter based on tricuspid annular displacement analysis that could be used to assess right ventricular (RV) systolic function. The value of RVLSF in the assessment of RV systolic function in recipients of heart transplantation (HT) and whether RVLSF can replace strain parameters
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Association of Achievement of the American Heart Association's Life's Essential 8 Goals With Incident Cardiovascular Diseases in the SHFS J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Pyone Yadanar Paing, Alyson J. Littman, Jessica A. Reese, Colleen M. Sitlani, Jason G. Umans, Shelley A. Cole, Ying Zhang, Tauqeer Ali, Amanda M. Fretts
BackgroundCardiovascular disease (CVD) is a leading cause of morbidity and mortality in American Indian people. In 2022, the American Heart Association developed the Life's Essential 8 goals to promote cardiovascular health (CVH) for Americans, composed of diet, physical activity, nicotine exposure, sleep, body mass index, blood lipids, blood pressure, and blood glucose. We examined whether achievement
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Correction to: Comparison of Effectiveness Among Different Sodium‐Glucose Cotransporter‐2 Inhibitors According to Underlying Conditions: A Network Meta‐Analysis of Randomized Controlled Trials J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-12
In the article by Ryoma Kani et al, “Comparison of Effectiveness Among Different Sodium‐Glucose Cotransporter‐2 Inhibitors According to Underlying Conditions: A Network Meta‐Analysis of Randomized Controlled Trials,” which published online January 31, 2024 (J Am Heart Assoc. 2024;13:e031805. DOI: 10.1161/JAHA.123.031805) and was included in the February 6, 2024 issue of the journal, a correction was
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Galectin‐3, Metabolic Risk, and Incident Heart Failure: The ARIC Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-12 Justin B. Echouffo‐Tcheugui, Sui Zhang, Roberta Florido, James S. Pankow, Erin D. Michos, Ronald B. Goldberg, Vijay Nambi, Gary Gerstenblith, Wendy S. Post, Roger S. Blumenthal, Christie M. Ballantyne, Josef Coresh, Elizabeth Selvin, Chiadi E. Ndumele
BackgroundIt is unclear how metabolic syndrome (MetS) and diabetes affect Gal‐3 (galectin 3) levels and the resulting implications for heart failure (HF) risk. We assessed relationships of MetS and diabetes with Gal‐3, and their joint associations with incident HF.Methods and ResultsWe included 8445 participants without HF (mean age, 63 years; 59% men; 16% Black race) at ARIC (Atherosclerosis Risk
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Integrative Assessment of Cardiopulmonary Fitness Using Cardiopulmonary Exercise Test With Supine Bicycle Echocardiography in Patients Presenting Dyspnea J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-12 Jiesuck Park, Houng‐Beom Ahn, Hyejung Choi, Hong‐Mi Choi, In‐Chang Hwang, Yeonyee E. Yoon, Goo‐Yeong Cho
BackgroundCardiopulmonary exercise test (CPET) with supine bicycle echocardiography (SBE) enables comprehensive physiologic assessment during exercise. We characterized cardiopulmonary fitness by integrating CPET‐SBE parameters and evaluated its prognostic value in patients presenting with dyspnea.Methods and ResultsWe retrospectively reviewed 473 consecutive patients who underwent CPET‐SBE for dyspnea
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Ankle–Brachial Index and Risk of Sudden Cardiac Death in the Community: The ARIC Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Takeki Suzuki, Xiaoqian Zhu, Selcuk Adabag, Kunihiro Matsushita, Kenneth R. Butler, Michael E. Griswold, Alvaro Alonso, Wayne Rosamond, Nona Sotoodehnia, Thomas H. Mosley
BackgroundSudden cardiac death (SCD) is a significant global public health problem accounting for 15% to 20% of all deaths. A great majority of SCD is associated with coronary heart disease, which may first be detected at autopsy. The ankle–brachial index (ABI) is a simple, noninvasive measure of subclinical atherosclerosis. The purpose of this study was to examine the relationship between ABI and
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National Trends of Vascular Risk Factor Control Among Stroke Survivors: From the National Health and Nutrition Examination Survey 2009 to 2020 J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Hend Mansoor, Daniel Manion, Kara J. Swafford, Gregory Jicha, Daniela Moga
BackgroundContemporary data describing the national trends on vascular risk factor control among stroke survivors are limited.Methods and ResultsThis is a cross‐sectional analysis of the National Health and Nutrition Examination Survey cycles 2009 to 2010 to 2017 to March 2020. Adults (≥18 years of age) with a self‐reported diagnosis of stroke were identified. Age‐adjusted trends in hypertension, diabetes
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Patient Screening for Self‐Expanding Percutaneous Pulmonary Valves Using Virtual Reality J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Jenny E. Zablah, Jeannie Than, Lorna P. Browne, Salvador Rodriguez, Gareth J. Morgan
BackgroundIn recent years, self‐expanding technology to treat pulmonary regurgitation in the native right ventricular outflow tract became Food and Drug Administration approved in the United States and is now routinely used. The current practice for selection of patients who are candidates for these devices includes screening for “anatomic fit,” performed by each of the manufacturing companies. Our
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High‐Sensitivity Cardiac Troponin T and Cognitive Function Over 12 Months After Stroke—Results of the DEMDAS Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Regina von Rennenberg, Christian H. Nolte, Thomas G. Liman, Simon Hellwig, Christoph Riegler, Jan F. Scheitz, Marios K. Georgakis, Rong Fang, Felix J. Bode, Gabor C. Petzold, Peter Hermann, Inga Zerr, Michael Goertler, Kathleen Bernkopf, Silke Wunderlich, Martin Dichgans, Matthias Endres
BackgroundSubclinical myocardial injury in form of hs‐cTn (high‐sensitivity cardiac troponin) levels has been associated with cognitive impairment and imaging markers of cerebral small vessel disease (SVD) in population‐based and cardiovascular cohorts. Whether hs‐cTn is associated with domain‐specific cognitive decline and SVD burden in patients with stroke remains unknown.Methods and ResultsWe analyzed
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Need for a Cardiogenic Shock Team Collaborative—Promoting a Team‐Based Model of Care to Improve Outcomes and Identify Best Practices J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Balimkiz Senman, Jacob C. Jentzer, Christopher F. Barnett, Jason A. Bartos, David D. Berg, Sharon Chih, Stavros G. Drakos, David M. Dudzinski, Andrea Elliott, Ann Gage, James M. Horowitz, P. Elliott Miller, Shashank S. Sinha, Behnam N. Tehrani, Eugene Yuriditsky, Saraschandra Vallabhajosyula, Jason N. Katz
Cardiogenic shock continues to carry a high mortality rate despite contemporary care, with no breakthrough therapies shown to improve survival over the past few decades. It is a time‐sensitive condition that commonly results in cardiovascular complications and multisystem organ failure, necessitating multidisciplinary expertise. Managing patients with cardiogenic shock remains challenging even in well‐resourced
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Addressing Knowledge Gaps in the Primary Prevention of Atherosclerotic Heart Disease J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Samuel S. Gidding
In the past 30 years, the introduction of new lipid‐lowering drugs, beginning with statins, has dramatically altered the outlook for atherosclerotic cardiovascular disease (ASCVD), a pathologic process, which after decades of exposure to elevated low‐density lipoprotein cholesterol (LDL‐C) and other established risk factors culminates in myocardial infarction, stroke, or peripheral artery disease.1
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Relationship of Mild to Moderate Impairment of Left Ventricular Ejection Fraction With Fatal Ventricular Arrhythmic Events in Cardiac Sarcoidosis J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Yuka Akama, Yudai Fujimoto, Yuya Matsue, Daichi Maeda, Kenji Yoshioka, Taishi Dotare, Tsutomu Sunayama, Takeru Nabeta, Yoshihisa Naruse, Takeshi Kitai, Tatsunori Taniguchi, Shuntaro Sato, Hidekazu Tanaka, Takahiro Okumura, Yuichi Baba, Tohru Minamino
BackgroundCurrent guidelines recommend placing an implantable cardiac defibrillator for patients with cardiac sarcoidosis and a severely impaired left ventricular ejection fraction (LVEF) of ≤35%. In this study, we determined the association between mild or moderate LVEF impairment and fatal ventricular arrhythmic event (FVAE).Methods and ResultsWe retrospectively analyzed 401 patients with cardiac
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Harnessing RNA Interference for Cholesterol Lowering: The Bench‐to‐Bedside Story of Inclisiran J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Michael J. Wilkinson, Archna Bajaj, Margaret E. Brousseau, Pam R. Taub
Lowering low‐density lipoprotein cholesterol (LDL‐C) is a cornerstone of reducing risk for atherosclerotic cardiovascular disease. Despite the approval of nonstatin therapies for LDL‐C lowering over the past 2 decades, these medications are underused, and most patients are still not at guideline‐recommended LDL‐C goals. Barriers include poor adherence, clinical inertia, concern for side effects, cost
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Stroke Causes DNA Methylation at Ncx1 Heart Promoter in the Brain Via DNMT1/MeCP2/REST Epigenetic Complex J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Natascia Guida, Angelo Serani, Luca Sanguigno, Luigi Mascolo, Ornella Cuomo, Salvatore Fioriniello, Domenico Marano, Floriana Della Ragione, Serenella Anzilotti, Paola Brancaccio, Pasquale Molinaro, Giuseppe Pignataro, Lucio Annunziato, Luigi Formisano
BackgroundREST (Repressor‐Element 1 [RE1]‐silencing transcription factor) inhibits Na+/Ca2+exchanger‐1 (Ncx1) transcription in neurons through the binding of RE1 site on brain promoter (Br) after stroke. We identified a new putative RE1 site in Ncx1 heart promoter (Ht) sequence (Ht‐RE1) that participates in neuronal Ncx1 transcription. Because REST recruits DNA‐methyltransferase‐1 (DNMT1) and MeCP2
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Epidermal Growth Factor‐Like Repeats and Discoidin I‐Like Domains 3 Deficiency Attenuates Dilated Cardiomyopathy by Inhibiting Ubiquitin Specific Peptidase 10 Dependent Smad4 Deubiquitination J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Mengmeng Zhao, Zihui Zheng, Shanshan Peng, Yao Xu, Jishou Zhang, Jianfang Liu, Wei Pan, Zheng Yin, Shuwan Xu, Cheng Wei, Menglong Wang, Jun Wan, Juan‐Juan Qin
BackgroundDilated cardiomyopathy (DCM) is the leading cause of heart failure with a poor prognosis. Recent studies suggest that endothelial to mesenchymal transition (EndMT) may be involved in the pathogenesis and cardiac remodeling during DCM development. EDIL3 (epidermal growth factor‐like repeats and discoidin I‐like domains 3) is an extracellular matrix glycoprotein that has been reported to promote
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Use of Sodium‐Glucose Cotransporter‐2 Inhibitors and Angiotensin Receptor‐Neprilysin Inhibitors in Patients With Atrial Fibrillation and Heart Failure From 2021 to 2022: An Analysis of Real‐World Data J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Alvaro Alonso, Alanna A. Morris, Ashley I. Naimi, Aniqa B. Alam, Linzi Li, Vinita Subramanya, Lin Yee Chen, Pamela L. Lutsey
BackgroundContemporary use of sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) and angiotensin receptor‐neprilysin inhibitors (ARNi) in patients with atrial fibrillation (AF) and heart failure (HF) has not been described.Methods and ResultsWe analyzed the MarketScan databases for the period January 1, 2021 to July 30, 2022. Validated algorithms were used to identify patients with AF and HF, and to
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Disparities in Race and Ethnicity Reporting and Representation for Clinical Trials in Stroke: 2010 to 2020 J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Hely D. Nanavati, Mudasir Andrabi, Yurany A. Arevalo, Evan Liu, Jeffrey Shen, Chen Lin
BackgroundRacial and ethnic minority groups are at a higher stroke risk and have poor poststroke outcomes. The aim of this study was to assess the frequency of race reporting and proportions of race and ethnicity representation in stroke‐related clinical trials.Methods and ResultsThis is a descriptive study of stroke‐related clinical trials completed between January 1, 2010 and December 31, 2020, and
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Work Status, Functional Recovery, and Quality of Life of Cardiac Arrest Survivors After Hospital Discharge J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Yi‐Wen Wu, Tai‐Yuan Chen, Chien‐Hua Huang, Yu‐Jen Chu, Wei‐Ting Chen, Kuan‐Ting Lu, Wei‐Tien Chang, Hooi‐Nee Ong, Wen‐Jone Chen, Min‐Shan Tsai
With advances in resuscitation science and post–cardiac arrest care, an increasing number of individuals who experience cardiac arrest are surviving hospital discharge. Optimizing the quality of life and functional outcomes for these survivors after discharge becomes essential. There is a lack of data concerning the medical service requirement, work status, and quality of life of cardiac arrest survivors
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Mendelian Randomization in Pulmonary Arterial Hypertension: Unveiling Early Insights With Promise for Future Discoveries J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Steeve Provencher, Benoit J. Arsenault, Sebastien Bonnet
Pulmonary arterial hypertension (PAH) is a complex condition characterized by the gradual restructuring of the distal pulmonary arteries, culminating in right ventricular failure and premature mortality.1 Substantial progress has been achieved in unraveling the risk factors and mechanisms underpinning the onset and progression of this disease. The landmark discovery of germline mutations associated
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Beyond the Beaten Path of Right Ventricular Assessment: Using Right Ventricular Fractional Shortening in Patients With Heart Transplants J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-08 Noura Alturaif, Sula Mazimba
Right ventricular (RV) dysfunction is associated with increased mortality and morbidity after heart transplantation.1 Despite advances in cardiac surgery and perioperative care, RV failure remains a common clinical problem. It is responsible for about half of the early cardiac complications posttransplantation, including 20% of mortalities.2, 3 Recovery from RV dysfunction in the early postoperative
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JAHA Go Red for Women Spotlight on Women and Cardiovascular Disease and Stroke J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-07 Mahasin S. Mujahid, Pamela N. Peterson
For many years, the American Heart Association has emphasized the importance of understanding sex‐related differences in cardiovascular disease and stroke. During Go Red for Women month, the goal is to increase public awareness and knowledge of the impact of cardiovascular disease among women as well as highlight important scientific findings regarding sex‐specific epidemiology, risk factors, and outcomes
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Dyslipidemia in American Indian Adolescents and Young Adults: Strong Heart Family Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-03-06 Jessica A. Reese, Mary J. Roman, Jason F. Deen, Tauqeer Ali, Shelley A. Cole, Richard B. Devereux, Amanda M. Fretts, Wm. James Howard, Elisa T. Lee, Kimberly Malloy, Jason G. Umans, Ying Zhang
BackgroundAlthough many studies on the association between dyslipidemia and cardiovascular disease (CVD) exist in older adults, data on the association among adolescents and young adults living with disproportionate burden of cardiometabolic disorders are scarce.Methods and ResultsThe SHFS (Strong Heart Family Study) is a multicenter, family‐based, prospective cohort study of CVD in an American Indian
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Placenta‐Heart‐Brain Connection in Congenital Heart Disease J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-02-29 Cynthia M. Ortinau, Jane W. Newburger
Increasing recognition of the critical role of the placenta in the long‐term health of the fetus and mother has generated two important and evolving areas of research: the developmental origins of health and disease (DOHaD) and cardiovascular health after maternal placental syndromes (CHAMPS).1 Yet, the human placenta remains a poorly understood organ. The Human Placenta Project (HPP) was launched
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Inverted U‐Shaped Association of Plasma Resolvin D2 With Atherosclerotic Cardiovascular Disease and the Mediation Effects of Serum Cholesterol: A Chinese Community‐Based Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-02-29 Bingyue Liu, Jin Zhang, Kexin Zhang, Mengyuan Li, Yang Jing, Shujun Gu, Hongzhan Ding, Yanyu Liang, Hui Zhou, Chen Dong
BackgroundResolvin D2 (RvD2) has been reported to protect against the development of atherosclerosis in animal models. The objective of this study was to examine the prospective association between plasma RvD2 and the risk of atherosclerotic cardiovascular disease (ASCVD) at the population level.Methods and ResultsA cohort of 2633 community‐dwelling individuals aged 35–60 years was followed for 8 years
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Myosin Light Chain Phosphatase Plays an Important Role in Cardiac Fibrosis in a Model of Mineralocorticoid Receptor‐Associated Hypertension J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-02-29 Zhe Ye, Ryuji Okamoto, Hiromasa Ito, Rie Ito, Keishi Moriwaki, Mizuki Ichikawa, Lupiya Kimena, Yusuf Ali, Masaaki Ito, Celso E. Gomez‐Sanchez, Kaoru Dohi
BackgroundMyosin phosphatase targeting subunit 2 (MYPT2) is an important subunit of cardiac MLC (myosin light chain) phosphatase, which plays a crucial role in regulating the phosphorylation of MLC to phospho‐MLC (p‐MLC). A recent study demonstrated mineralocorticoid receptor‐related hypertension is associated with RhoA/Rho‐associated kinase/MYPT1 signaling upregulation in smooth muscle cells. Our
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Emergency Department Use and Hospital Mortality Among Heart Transplant Recipients in the United States J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-02-29 Luise Holzhauser, Nosheen Reza, Jonathan J. Edwards, Edo Y. Birati, Anjali T. Owens, Rhondalyn McLean, Katsuhide Maeda, Matthew J. O'Connor, Joseph W. Rossano, Antara Mondal, Hannah Katcoff, Jonathan B. Edelson
BackgroundAnnual heart transplant (HT) volumes have increased, as have post‐HT outpatient care needs. Data on HT‐related emergency department (ED) visits are limited.Methods and ResultsA retrospective analysis of 177 450 HT patient ED visits from the 2009 to 2018 Nationwide Emergency Department Sample was conducted. HT recipients, primary diagnoses, and comorbidities associated with ED visits were
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Potential Protein Signatures for Recurrence Prediction of Ischemic Stroke J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-02-29 Chengyi Zhang, Yang Liu, Huimin Zhu, Xinying Huang, Cang Guo, Si Cheng, Meng Yuan, Yong Jiang, Xia Meng, S. Claiborne Johnston, Yongjun Wang, Wei‐Na Jin, Fu‐Dong Shi
BackgroundAcute ischemic stroke is a major cause of mortality and disability worldwide, with approximately 7.4% to 7.7% recurrence within the first 3 months. This study aimed to identify potential biomarkers for predicting stroke recurrence.Methods and ResultsWe conducted a nested case–control study using a hospital‐based cohort from the Third China National Stroke Registry selecting 214 age‐ and sex‐matched
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Placental Pathology Contributes to Impaired Volumetric Brain Development in Neonates With Congenital Heart Disease J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-02-29 Maaike Nijman, Lotte E. van der Meeren, Peter G. J. Nikkels, Raymond Stegeman, Johannes M. P. J. Breur, Nicolaas J. G. Jansen, Henriette ter Heide, Trinette J. Steenhuis, Roel de Heus, Mireille N. Bekker, Nathalie H. P. Claessens, Manon J. N. L. Benders
BackgroundNeonates with congenital heart disease are at risk for impaired brain development in utero, predisposing children to postnatal brain injury and adverse long‐term neurodevelopmental outcomes. Given the vital role of the placenta in fetal growth, we assessed the incidence of placental pathology in fetal congenital heart disease and explored its association with total and regional brain volumes
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Kidney Function Trajectories and Right Heart Failure Following LVAD Implantation J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-02-29 Carl P. Walther, Andrew B. Civitello, Harveen K. Lamba, Nandan K. Mondal, Sankar D. Navaneethan
BackgroundPreoperative kidney dysfunction is a risk factor for right heart failure (RHF) after implantation of a left ventricular assist device (LVAD). However, characteristic kidney function trajectories before and after post‐LVAD RHF are uncertain, so we investigated this.Methods and ResultsWe identified individuals who received primary continuous‐flow LVAD implantation from July 1, 2014 to December
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Association Between ECG Abnormalities and Mortality in a Low‐Risk Population J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-02-29 Sung Ho Lee, Mi Yeon Lee, Jeonggyu Kang, Hyo‐In Choi, Seung‐Jae Lee, Jong‐Young Lee, Byung Jin Kim, Ki‐Chul Sung, Kyoung‐Min Park
BackgroundThe ECG is a simple, noninvasive screening method for cardiovascular disease and arrhythmia. The impact of ECG abnormality on mortality is not certain in low‐risk populations. To address this, we evaluated the association between ECG abnormality and mortality.Methods and ResultsWe retrospectively assessed baseline ECG and all‐cause mortality and cardiovascular mortality in 660 383 patients
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Correction to: Inference of Causal Relationships Between Genetic Risk Factors for Cardiometabolic Phenotypes and Female‐Specific Health Conditions J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-02-29
In the article by Brenda Xiao et al, “Inference of Causal Relationships Between Genetic Risk Factors for Cardiometabolic Phenotypes and Female‐Specific Health Conditions,” which published online on February 27, 2023 (J Am Heart Assoc. 2023;12:e026561) and appeared in the March 7, 2023 issue of the journal, acknowledgments and a funding source were omitted. The following has been added to the Acknowledgments
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Proteomic Associations of Adverse Outcomes in Human Heart Failure J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-02-29 Marie‐Joe Dib, Michael G. Levin, Lei Zhao, Ahmed Diab, Zhaoqing Wang, Christina Ebert, Oday Salman, Joe David Azzo, Sushrima Gan, Payman Zamani, Jordana B. Cohen, Dipender Gill, Stephen Burgess, Loukas Zagkos, Vanessa van Empel, A. Mark Richards, Rob Doughty, Ernst R. Rietzschel, Karl Kammerhoff, Erika Kvikstad, Joseph Maranville, Peter Schafer, Dietmar A. Seiffert, Francisco Ramirez‐Valle, David A
BackgroundIdentifying novel molecular drivers of disease progression in heart failure (HF) is a high‐priority goal that may provide new therapeutic targets to improve patient outcomes. The authors investigated the relationship between plasma proteins and adverse outcomes in HF and their putative causal role using Mendelian randomization.Methods and ResultsThe authors measured 4776 plasma proteins among
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Schizophrenia and Types of Stroke: A Mendelian Randomization Study J. Am. Heart Assoc. (IF 5.4) Pub Date : 2024-02-29 Shinya Nakada, Frederick K. Ho, Carlos Celis‐Morales, Jill P. Pell
BackgroundPrevious studies suggest an association between schizophrenia and stroke, but no studies have investigated stroke subtypes. We examined potential causal associations between schizophrenia and a range of atherosclerotic, embolic, and hemorrhagic stroke outcomes.Methods and ResultsTwo‐sample Mendelian randomization analyses were conducted. The summary‐level data (restricted to European ancestry)