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18F-FDG PET/CT and radiolabeled leukocyte SPECT/CT imaging for the evaluation of cardiovascular infection in the multimodality context: ASNC Imaging Indications (ASNC I2) Series Expert Consensus Recommendations from ASNC, AATS, ACC, AHA, ASE, EANM, HRS, IDSA, SCCT, SNMMI, and STS Heart Rhythm (IF 5.5) Pub Date : 2024-03-11 Jamieson M. Bourque, Ulrika Birgersdotter-Green, Paco E. Bravo, Ricardo P.J. Budde, Wengen Chen, Vivian H. Chu, Vasken Dilsizian, Paola Anna Erba, Cesia Gallegos Kattan, Gilbert Habib, Fabien Hyafil, Yiu Ming Khor, Jaimie Manlucu, Pamela Kay Mason, Edward J. Miller, Marc R. Moon, Matthew W. Parker, Gosta Pettersson, Robert D. Schaller, Riemer H.J.A. Slart, Jordan B. Strom, Bruce L. Wilkoff, Adam Williams
This document on cardiovascular infection, including infective endocarditis, is the first in the American Society of Nuclear Cardiology Imaging Indications (ASNC I) series to assess the role of radionuclide imaging in the multimodality context for the evaluation of complex systemic diseases with multi-societal involvement including pertinent disciplines. A rigorous modified Delphi approach was used
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Cardiac conduction disorders in young adults: clinical characteristics and genetic background of an underestimated population Heart Rhythm (IF 5.5) Pub Date : 2024-03-10 Cristina Balla MD-PhD, Alice Margutti, Beatrice De Carolis MD, Luca Canovi MD, Assunta Di Domenico MD, Ilaria Vivaldi MD, Francesco Vitali MD, Martina De Raffele MD, Michele Malagù MD, Biagio Sassone MD, Mauro Biffi MD, Rita Selvatici PhD, Alessandra Ferlini MD, Francesca Gualandi MD-PhD, Matteo Bertini MD-PhD
Cardiac conduction disorders (CCD) in patients <50 years are a rare and mostly unknown condition. We aimed to assess clinical characteristics and genetic background of patients < 50 years with CCD of unknown origin. We retrospectively review a consecutive series of patients with a diagnosis of CCD before the age of 50 referred to our Centre between January 2019 and December 2021. Patients underwent
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An unruly case of functional two-to-one atrioventricular block Heart Rhythm (IF 5.5) Pub Date : 2024-03-09 Muhammed Ali EKSI MD, Yasemin OZDEMIR SAHAN MD, Serhat KOCA MD, Ozcan OZEKE MD
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Systemic Infarcts Among Patients with Atrial Fibrillation Heart Rhythm (IF 5.5) Pub Date : 2024-03-09 Alexander P. Cabulong MPH, Janet J. Tang PhD, Justin T. Teraoka BS, Thomas A. Dewland MD, Gregory M. Marcus MD MAS FHRS
The epidemiology of atrial fibrillation (AF)-associated thromboembolic complications outside of ischemic strokes has not been thoroughly elucidated. To describe the epidemiology of AF-associated systemic infarcts and relevant interactions by sex and race/ ethnicity. Utilizing the Office of Statewide Health Planning and Development (OSHPD), we performed a longitudinal analysis of patients aged ≥ 18
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Interatrial Septal Pressure: A Novel Technique to Facilitate Safe Ablation of Periphrenic Right Atrial Tachycardias Heart Rhythm (IF 5.5) Pub Date : 2024-03-09 Muazzum M. Shah MD MS, Ryan T. Cunnane MD, Jackson J. Liang DO
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Comparisons of Long-Term Clinical Outcomes with Left Bundle Branch Pacing, Left Ventricular Septal Pacing and Biventricular Pacing for Cardiac Resynchronization Therapy Heart Rhythm (IF 5.5) Pub Date : 2024-03-09 Haojie Zhu MD PhD, Chaotong Qin MD, Anjie Du MD, Qian Wang MD, Chen He MD, Fengwei Zou MD, Xiaofei Li MD, Jin Tao MD, Chuangshi Wang PhD, Zhimin Liu MD, Siyuan Xue MD, Jiaxin Zeng MD, Zhiyong Qian MD PhD, Yao Wang MD PhD, Xiaofeng Hou MD, Kenneth A. Ellenbogen MD, Michael R. Gold MD PhD, Yan Yao MD PhD FHRS, Jiangang Zou MD PhD FHRS, Xiaohan Fan MD PhD
Left bundle branch pacing (LBBP) and left ventricular septal pacing (LVSP) are referred to as left bundle branch area pacing (LBBAP). This study investigated whether long-term clinical outcomes differ in patients undergoing LBBP, LVSP, and biventricular pacing (BiVP) for cardiac resynchronization therapy (CRT). Consecutive patients with reduced left ventricular ejection fraction (LVEF<50%) undergoing
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Supernormal Phase of Conduction Heart Rhythm (IF 5.5) Pub Date : 2024-03-08 Bernard Belhassen MD, Marcelo Elizari MD
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PULSED FIELD ABLATION PREVENTS LEFT ATRIAL RESTRICTIVE PHYSIOLOGY AFTER POSTERIOR WALL ISOLATION IN PATIENTS WITH PERSISTENT ATRIAL FIBRILLATION Heart Rhythm (IF 5.5) Pub Date : 2024-03-07 Ariel Banai MD, Ehud Chorin MD, Arie Lorin Schwartz MD, Yuval Levi MEng, Hend Sliman MD, Omri Feder MD, Dana Viskin MD, Sami Viskin MD, Shmuel Banai MD, Raphael Rosso MD.
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Arrhythmia detection using an implantable loop recorder after a negative electrophysiology study in Brugada syndrome: observations from a multicenter international registry Heart Rhythm (IF 5.5) Pub Date : 2024-03-07 Eusebio García-Izquierdo MD PhD, Chiara Scrocco MD, Julián Palacios-Rubio MD PhD, Amira Assaf MD, Tomás Ripoll-Vera MD PhD, Iván Hernandez-Betancor MD PhD, Pablo Ramos-Ruiz MD, Antonio Melero-Pita MD, Melodie Segura-Domínguez RN, Diego Jiménez-Sánchez MD, Victor Castro-Urda MD, Jorge Toquero-Ramos MD PhD, Sing-Chien Yap MD PhD, Elijah R. Behr MA MBBS MD, Ignacio Fernández-Lozano MD PhD
Risk stratification in Brugada syndrome (BrS) remains controversial. In this respect, the role of electrophysiology study (EPS) has been subject of debate. In some centers, it is common practice to use an implantable loop recorder (ILR) after a negative EPS to help risk stratification. However, the diagnostic value of this approach has never been specifically addressed. To describe the baseline characteristics
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Effect of Reference Electrode on Intracardiac Electrograms: Close Indifferent Electrode vs. Wilson Central Terminal Heart Rhythm (IF 5.5) Pub Date : 2024-03-07 Tasuku Yamamoto MD PhD, Masateru Takigawa MD PhD, Takatoshi Shigeta MD PhD, Claire A. Martin MD PhD, Junji Yamaguchi MD PhD, Miki Amemiya MD, Takashi Ikenouchi MD PhD, Miho Negishi MD, Iwanari Kawamura MD, Kentaro Goto MD PhD, Takuro Nishimura MD PhD, Tomomasa Takamiya MD PhD, Susumu Tao MD PhD, Shinsuke Miyazaki MD PhD FHRS, Masahiko Goya MD PhD, Tetsuo Sasano MD PhD
Unipolar electrograms (Uni-EGM) are an essential part of intracardiac mapping. Although Wilson Central Terminal (WCT) is conventionally used as a reference for signals, avoiding contamination by far-field and non-physiological signals is challenging. To explore the impact of an intracardiac indifferent reference electrode close to the recording electrodes, in lieu of WCT, on electrograms. Sinus node
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Characteristics of Contemporary Atrial Fibrillation Clinical Trials and Their Association With Industry Sponsorship Heart Rhythm (IF 5.5) Pub Date : 2024-03-06 Roy H. Lan MD, Ishan Paranjpe MD, Mohammad Saeed MD, Marco V. Perez MD
Industry sponsorship is an important source of funding for atrial fibrillation (AF) clinical trials, the implications of which have not been analyzed. The purpose of this study is to describe the characteristics of contemporary AF clinical trials and to evaluate their association with funding source. We systematically assessed all completed AF trials registered in the ClinicalTrials.gov database between
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Collateral Coronary Flow in the Interventricular Septum Detected on Intracardiac Echocardiography Imaging Heart Rhythm (IF 5.5) Pub Date : 2024-03-06 Fatima M. Ezzeddine MD, William R. Miranda MD, Jeremy D. Collins MD, Ammar M. Killu MBBS
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Evaluation of the in-vivo Chemical Reactivity of a Novel Co-polymer Insulation on Cardiac Leads in a Single-Center Study Heart Rhythm (IF 5.5) Pub Date : 2024-03-02 Rand Ibrahim, Kimberly Chaffin, Anand Shah, Stacy Westerman, Michael Lloyd, Neal Bhatia, Faisal M. Merchant, Mikhael El-Chami
Human data on the chemical stability of different transvenous lead materials and in particular Optim leads are lacking. We sought to study the chemical reactivity of insulation materials by analyzing the Molar mass of extracted pacing and defibrillator leads We collected extracted leads at Emory University Hospitals and sent leads with thermoplastic outer insulation material for molar mass analysis
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Optimal Cardiac Rhythm during Substrate Mapping in Scar-Related Ventricular Tachycardia: Significance of Wavefront Direction on Identifying Critical Sites Heart Rhythm (IF 5.5) Pub Date : 2024-03-01 Yasutoshi Shinoda, Yuki Komatsu, Masayuki Hattori, Yuka Oda, Yuto Iioka, Yuichi Hanaki, Hiro Yamasaki, Miyako Igarashi, Tomoko Ishizu, Akihiko Nogami
A rotational activation pattern (RAP) around the localized line of a conduction block often correlates with sites specific to the critical zones of ventricular tachycardia (VT). The wavefront direction during substrate mapping affects the manifestation of the RAP and line of block. This study aimed to investigate the most optimal cardiac rhythm for identifying RAP and line of block in substrate mapping
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Electrocardiographic predictors of atrial mechanical sensing in leadless pacemakers Heart Rhythm (IF 5.5) Pub Date : 2024-03-01 Daniel Hofer, Fabrizio Perucchini, Hermann Blessberger, Clemens Steinwender, Samantha Zehetleitner, Nadine Molitor, Ardan M. Saguner, Mikhael F. El-Chami, George Black, Marco Schiavone, Giovanni Forleo, Alessio Gasperetti, Jan Steffel, Fabian Noti, Andreas Haeberlin, Alexander Breitenstein
Leadless pacemakers (LP) capable of VDD pacing allow for atrioventricular synchrony through mechanical sensing of atrial contraction. Unfortunately, mechanical sensing is less reliable and less predictable than electrical sensing. We evaluated the P wave amplitude during sinus rhythm from pre-operative 12-lead ECGs as a predictor for atrial mechanical sensing in patients undergoing VDD LP implantation
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Symptomatic bradyarrhythmias in the athlete - underlying mechanisms and treatments Heart Rhythm (IF 5.5) Pub Date : 2024-02-28 Sami Al-Othman, Mark R. Boyett, Gwilym M. Morris, Aneil Malhotra, Pietro Mesirca, Matteo E. Mangoni, Alicia D’Souza
Bradyarrhythmias including sinus bradycardia and atrioventricular (AV) block are frequently encountered in endurance athletes especially at night. While these are well tolerated by the young athlete, there is evidence that generally from the fifth decade of life onwards, such arrhythmias can degenerate into pathological symptomatic bradycardia requiring pacemaker therapy. For many years, athletic bradycardia
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Complications of left bundle branch area pacing compared with biventricular pacing in candidates for resynchronization therapy: Results of a propensity score-matched analysis from a multicenter registry Heart Rhythm (IF 5.5) Pub Date : 2024-02-28 Pietro Palmisano, Gabriele Dell’Era, Federico Guerra, Ernesto Ammendola, Matteo Ziacchi, Mattia Laffi, Paolo Donateo, Alessandro Guido, Chiara Ghiglieno, Antonio Parlavecchio, Antonio Dello Russo, Gerardo Nigro, Mauro Biffi, Germano Gaggioli, Jacopo Senes, Giuseppe Patti, Michele Accogli, Giovanni Coluccia
Cardiac resynchronization therapy (CRT) with biventricular pacing (BVP) is a well-established therapy in patients with reduced left ventricular ejection fraction (LVEF), heart failure, and left bundle branch (LBB) block. LBB area pacing (LBBAP) has recently been shown to be a feasible and effective alternative to BVP. Comparative data on the risk of complications between LBBAP and BVP among patients
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Both HFpEF and HFmrEF Should be Included in Calculating CHA2DS2–VASc score: a Taiwanese Longitudinal Cohort Heart Rhythm (IF 5.5) Pub Date : 2024-02-27 Chien-Chien Cheng, Pang-Shuo Huang, Jien-Jiun Chen, Fu-Chun Chiu, Sheng-Nan Chang, Yi-Chih Wang, Cho-Kai Wu, Juey-Jen Hwang, Chia-Ti Tsai
Congestive heart failure (CHF) as a risk of stroke in AF patients mainly referred to patients with left ventricular systolic dysfunction (HFrEF). Whether this should include patients with preserved ejection fraction (HFpEF) is debatable. To investigate the variation in stroke risk between atrial fibrillation (AF) patients with HFpEF, HFmrEF, and HFrEF for enhancing risk assessment and subsequent management
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Feasibility of carbon dioxide insufflation and impact on epicardial approach utilization for ventricular tachycardia ablation in a mid-volume referral center Heart Rhythm (IF 5.5) Pub Date : 2024-02-23 Giulio Zucchelli, Matteo Parollo, Andrea Di Cori, Lorenzo Mazzocchetti, Luca Segreti, Gino Grifoni, Marco Torre, Sara Sbragi, Raffaele De Lucia, Valentina Barletta, Antonio Canu, Stefano Viani, Maria Grazia Bongiorni
Epicardial access is often crucial for successful ventricular tachycardia (VT) ablation, but it's often burdened by significant procedural risk. Intentional coronary vein exit and intrapericardial CO insufflation (EpiCO) can facilitate subxiphoid pericardial access. This prospective study aims at assessing procedural feasibility, safety and impact of the introduction of intrapericardial CO insufflation
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Prevalence of frequent premature ventricular contractions and nonsustained ventricular tachycardia in older women screened for atrial fibrillation in the Women’s Health Initiative Heart Rhythm (IF 5.5) Pub Date : 2024-02-23 Sofia E. Gomez, Joseph Larson, Mark A. Hlatky, Fatima Rodriguez, Matthew Wheeler, Philip Greenland, Michael LaMonte, Victor Froelicher, Marcia L. Stefanick, Robert Wallace, Charles Kooperberg, Lesley F. Tinker, Jenny Schoenberg, Elsayed Z. Soliman, Mara Z. Vitolins, Nazmus Saquib, Tomas Nuño, Bernhard Haring, Marco V. Perez
Frequent premature ventricular contractions (PVCs) and nonsustained ventricular tachycardia (NSVT) have been associated with cardiovascular disease and mortality. Their prevalence, especially in ambulatory populations, is under-studied and limited by few female participants and the use of short-duration (24-48 hour) monitoring. Report the prevalence of frequent PVCs and NSVT in a community-based population
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What Electrophysiologists Should Know about Cardiac Implantable Electronic Device Recalls Heart Rhythm (IF 5.5) Pub Date : 2024-02-23 Robert G. Hauser, Charles D. Swerdlow
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Diagnostic approach to the Pediatric Brugada Syndrome: A survey of international common practice Heart Rhythm (IF 5.5) Pub Date : 2024-02-23 Christine Stratmann, Maria Cecilia Gonzalez Corcia
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ECG-only Explainable Deep Learning Algorithm Predicts the Risk for Malignant Ventricular Arrhythmia in Phospholamban Cardiomyopathy Heart Rhythm (IF 5.5) Pub Date : 2024-02-23 Rutger R. van de Leur, Remco de Brouwer, Hidde Bleijendaal, Tom E. Verstraelen, Belend Mahmoud, Ana Perez-Matos, Cathelijne Dickhoff, Bas A. Schoonderwoerd, Tjeerd Germans, Arjan Houweling, Paul A. van der Zwaag, Moniek GPJ. Cox, J. Peter van Tintelen, Anneline SJM. te Riele, Maarten P. van den Berg, Arthur AM. Wilde, Pieter A. Doevendans, Rudolf A. de Boer, René van Es
Phospholamban () p.(Arg14del) variant carriers are at risk of developing malignant ventricular arrhythmias (MVA). Accurate risk stratification allows for timely implantation of intracardiac defibrillators (ICD) and is currently performed using a multimodality prediction model. This study aims to investigate whether an explainable deep learning-based approach allows for risk prediction using only electrocardiogram
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CLINICAL OUTCOMES OF PATIENTS REFERRED FOR LEFT ATRIAL APPENDAGE EXCLUSION WHO DID AND DID NOT UNDERGO THE PROCEDURE Heart Rhythm (IF 5.5) Pub Date : 2024-02-23 Trisha Gupte, Mohammed Al-Sadawi, Tiffany Luke, Eryn K. Smith, Nimita Mehta, Jackson J. Liang, Aman Chugh, Fred Morady, Matthew A. Romano, Hakan Oral, Michael Ghannam
Left arial appendage exclusion (LAAE) is an effective alternative to long-term anticoagulation in patients with atrial fibrillation (AF). Not all patients considered for LAAE undergo the procedure due to ineligibility, anatomical or medical constraints, and patient preference. To report on the management strategies and long-term clinical outcomes of patients referred to a dedicated multidisciplinary
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Calpain inhibition protects against atrial fibrillation by mitigating diabetes-associated atrial fibrosis and calcium handling dysfunction in type 2 diabetes mice Heart Rhythm (IF 5.5) Pub Date : 2024-02-21 Qing Wang, Jinxiang Yuan, Hua Shen, Qi Zhu, Biyi Chen, Jinxi Wang, Weizhong Zhu, Mark A. Yorek, Duane D. Hall, Zhinong Wang, Long-Sheng Song
Diabetes mellitus (DM) is a major risk factor for atrial structural remodeling and atrial fibrillation (AF). Calpain activity is hypothesized to promote atrial remodeling and AF. To investigate the role of calpain in diabetes-associated atrial fibrillation, fibrosis, and calcium handling dysfunction. DM-associated AF was induced in wildtype mice and in mice overexpressing the calpain inhibitor calpastatin
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Ventricular Arrhythmia Inducibility in Porcine Infarct Model after Stereotactic Body Radiation Therapy Heart Rhythm (IF 5.5) Pub Date : 2024-02-21 Krishna Kancharla, Adam Olson, Siamak Salavatian, Yuki Kuwabara, Yuriy Martynyuk, Partha Dutta, Sathish Vasamsetti, Aman Mahajan, Kimberley Howard-Quijano, Samir Saba
Ventricular arrhythmia (VA) is the primary mechanism of sudden death in patients with structural heart disease. Cardiac stereotactic body radiation therapy (SBRT) delivered to the scar in the left ventricle (LV) significantly reduces the burden of VA To investigate the impact of SBRT on scar morphology and VA inducibility in a porcine infarct model Myocardial infarction (MI) was created in 10 Yorkshire
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The role of Atrioventricular Delay in Determining Right Ventricle Function with Left Bundle Pacing Heart Rhythm (IF 5.5) Pub Date : 2024-02-20 Marina Strocchi, Steven A. Niederer, Christopher A. Rinaldi
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Association between Neighborhood Household Income and Inpatient Atrial Fibrillation Outcomes Heart Rhythm (IF 5.5) Pub Date : 2024-02-19 Prasanti A. Kotta, Vijay Nambi, Arunima Misra, Hamid Afshar, Mihail G. Chelu, Khurram Nasir, Dmitry Abramov, Abdul Mannan Khan
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Predictor of A4-amplitude using preprocedural electrocardiography in patients with leadless pacemakers Heart Rhythm (IF 5.5) Pub Date : 2024-02-19 Shunsuke Kawatani, Yasuhito Kotake, Aiko Takami, Kensuke Nakamura, Takuya Tomomori, Akihiro Okamura, Masaru Kato, Kazuhiro Yamamoto
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Conduction System Pacing versus Biventricular Pacing in Heart Failure with Reduced Ejection Fraction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Heart Rhythm (IF 5.5) Pub Date : 2024-02-19 Iuri Ferreira Felix, Michelle Collini, Rafaela Fonseca, Camila Guida, Luciana Armaganijan, Jeffrey Sean Healey, Guilherme Carvalho
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Tropomyosin-troponin complex in inherited cardiomyopathies Heart Rhythm (IF 5.5) Pub Date : 2024-02-19 Christian Krijger Juárez, Vasco Sequeira, Malou van den Boogaard, Christiaan C. Veerman, Nicola J. Hoetjes, Edwin Poel, Michael W.T. Tanck, Ronald H. Lekanne Deprez, Alexa M.C. Vermeer, Jolanda van der Velden, Ahmad S. Amin
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Validation of the PRAETORIAN Score in a large S-ICD collective – usefulness in clinical routine Heart Rhythm (IF 5.5) Pub Date : 2024-02-19 Florian Doldi, Gerrit Frommeyer, Andreas Löher, Christian Ellermann, Julian Wolfes, Fatih Güner, Mathis Zerbst, Hauke Engelke, Dennis Korthals, Florian Reinke, Lars Eckardt, Kevin Willy
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Author's reply to The role of Atrioventricular Delay in Determining Right Ventricle Function with Left Bundle Pacing Heart Rhythm (IF 5.5) Pub Date : 2024-02-19 Fangyan Tian, Ao Liu, Haiyan Chen, Xianhong Shu
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Personalized Cardiac Resynchronization Therapy Guided by Real-time Electrocardiographic Imaging for Non-Left Bundle Branch Block patients Heart Rhythm (IF 5.5) Pub Date : 2024-02-16 Tsz-Kin Tam, Alex C.K. Au, Joseph Y.S. Chan, Chin-Pang Chan, Li-Li Cheung, Yuet-Wong Cheng, Fiona S.M. Yuen, Bryan P. Yan
Heart failure patients with non-left bundle branch block (non-LBBB) QRS pattern have limited response rate to biventricular pacing (BVP). A personalized cardiac resynchronization therapy (CRT) implantation approach guided by real-time electrocardiographic imaging (ECGi) was studied. Twenty patients with left ventricular ejection fraction (LVEF) ≤35%, QRS duration ≥120ms and non-LBBB (13 right bundle
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Is Left Atrial Appendage Occlusion “Better” Than Direct Oral Anticoagulants in Very High-Risk Patients with Atrial Fibrillation? Heart Rhythm (IF 5.5) Pub Date : 2024-02-16 Andrea M. Russo
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Managing Vagal Responses Induced By Pulsed Field Ablation:Go Right First? Heart Rhythm (IF 5.5) Pub Date : 2024-02-16 Pasquale Santangeli, Raphael Rosso, Jose Carlos Pachon
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Association of Transcatheter Left Atrial Appendage Occlusion with Acute Changes in Left Atrial Pressure: An Invasive Hemodynamic Study Heart Rhythm (IF 5.5) Pub Date : 2024-02-15 Hasan S. Alarouri, Gerardo V. Lo Russo, Alejandra Chavez Ponce, Abdul-Rahman Akkawi, Abdulah Mahayni, Agata Sularz, Ammar M. Killu, Trevor Simard, Gurpreet Singh, William R. Miranda, Mohamad Alkhouli
The hemodynamic effects of transcatheter left atrial appendage occlusion (LAAO) remain unclear. We sought to assess the effect of LAAO on invasive hemodynamics and their correlation with clinical outcomes. We recorded mean left atrial pressure (mLAP) before and after device deployment. We assessed: (a) the prevalence and predictors of mLAP increase post-deployment; (b) the association between significant
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Clinical characterization of type 1 long QT syndrome caused by C-terminus Kv7.1 variants Heart Rhythm (IF 5.5) Pub Date : 2024-02-15 Asami Kashiwa, Hideki Itoh, Takeru Makiyama, Yuko Wada, Junichi Ozawa, Koichi Kato, Megumi Fukuyama, Tadashi Nakajima, Seiko Ohno, Minoru Horie
Variants in the gene, encoding the α-subunit of the slow component of delayed rectifier K channel, Kv7.1, cause long-QT syndrome type 1 (LQT1). The location of variants may be one of factors in determining prognosis. However, detailed genotype-phenotype relationships associated with C-terminus variants remain unelucidated. We investigated the clinical characteristics and variant-specific arrhythmic
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A step forward towards conduction system pacing–based cardiac resynchronization therapy, albeit a small one. Heart Rhythm (IF 5.5) Pub Date : 2024-02-15 Marek Jastrzębski, Pugazhendhi Vijayaraman
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Efficacy of Left Bundle Branch Area Pacing Versus Biventricular Pacing in Cardiac Resynchronization Therapy Patients: Select Site - Cohort Study Heart Rhythm (IF 5.5) Pub Date : 2024-02-15 Jenish P. Shroff, Deep Chandh Raja, Lukah Q. Tuan, Sreevilasam P. Abhilash, Abhinav Mehta, Walter P. Abhayaratna, Prashanthan Sanders, Rajeev K. Pathak
Cardiac resynchronization therapy (CRT) is typically attempted with biventricular pacing. One-third of patients are non-responders. Left bundle branch area pacing (LBBAP) has been evaluated as an alternative means. To assess the feasibility and clinical response of permanent LBBAP as an alternative to biventricular pacing. Of 479 consecutive patients referred with heart failure (HF), 50 with biventricular
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Sex difference in atrial scar prevalence: What can we learn from STABLE-SR-III Trial? Heart Rhythm (IF 5.5) Pub Date : 2024-02-15 Nan Wu, Wenjie Liu, Gang Yang, Hongwu Chen, Weizhu Ju, Mingfang Li, Kai Gu, Hailei Liu, Chang Cui, Cheng Cai, Xingxing Sun, Shaojie Chen, Minglong Chen
Female sex has long been recognized to present higher risk of stroke and atrial fibrillation (AF) recurrence after circumferential pulmonary vein isolation (CPVI) than male. However, the underlying mechanisms and benefits of additional low-voltage area (LVA) modification in women remain unknown. To investigate differences in atrial substrate and efficacy of additive LVA ablation between sex subgroups
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Electrocardiography deep-learning models to predict high-risk Imaging features in Patients with Hypertrophic Cardiomyopathy: Can It Change Clinical Practice? Heart Rhythm (IF 5.5) Pub Date : 2024-02-15 Ghassan Bidaoui, Hadi Younes, Nassir Marrouche
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Clinical Utility of QRS Duration Normalized to Left Ventricular Volume for Predicting Cardiac Resynchronization Therapy Efficacy in Patients with "Mid-Range" QRS Duration Heart Rhythm (IF 5.5) Pub Date : 2024-02-15 Nobuhiko Yamamoto, Takashi Noda, Makoto Nakano, Tomohiro Ito, Hiroyuki Sato, Hideka Hayashi, Takahiko Chiba, Yuhi Hasebe, Nobuhiko Ueda, Tsukasa Kamakura, Kohei Ishibashi, Satoshi Miyata, Kengo Kusano, Satoshi Yasuda
Cardiac resynchronization therapy (CRT) is effective for patients with heart failure with a QRS duration (QRSd) 150 milliseconds (ms). However, its beneficial effect appears to be limited for those with a "mid-range" QRSd (120–149 ms). Recent studies have demonstrated that modifying the QRSd to left ventricular end-diastolic volume (LVEDV), modified QRSd, improves the prediction of clinical outcomes
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Relationship between sex, body size, and cardiac resynchronization therapy benefit: A patient-level meta-analysis of randomized controlled trials Heart Rhythm (IF 5.5) Pub Date : 2024-02-14 Daniel J. Friedman MD, Antonio Olivas-Martinez MD, Frederik Dalgaard MD PhD, Marat Fudim MD MHS, William T. Abraham MD, John G.F. Cleland MD PhD, Anne B. Curtis MD, Michael R. Gold MD PhD, Valentina Kutyifa MD PhD, Cecilia Linde MD PhD, Anthony S. Tang MD, Fatima Ali-Ahmed MD, Lurdes Y.T. Inoue PhD, Gillian D. Sanders PhD, Sana M. Al-Khatib MD MHS
Women might benefit more than men from cardiac resynchronization therapy (CRT) and do so at shorter QRS durations. This meta-analysis was performed to determine whether sex-based differences in CRT effects are better accounted for by height, body surface area (BSA), or left ventricular end-diastolic dimension (LVEDD). We analyzed patient-level data from CRT trials (MIRACLE, MIRACLE ICD, MIRACLE ICD
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Reply to the Editor—Postural Orthostatic Tachycardia Syndrome After COVID-19 Vaccination Heart Rhythm (IF 5.5) Pub Date : 2024-02-14 Debbie Lin Teodorescu MD MEng, Peng-Sheng Chen MD
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To the Editor—Small Fiber Neuropathy Is Responsible for POTS in SARS-CoV-2 Vaccines Heart Rhythm (IF 5.5) Pub Date : 2024-02-13 J, o, s, e, f, , F, i, n, s, t, e, r, e, r, , M, D, , P, h, D
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A novel computational platform to analyze left atrial voltage acquired from electroanatomic mapping Heart Rhythm (IF 5.5) Pub Date : 2024-02-13 Julia H. Indik MD PhD, Alvaro Altamirano Ufion MD, Bradford Whitaker BA, Travis Geyer BS, Mahesh Balakrishnan MBBS, Khurram Butt MD, Jacob Klewer MD, Robert A. Indik PhD, Mathew D. Hutchinson MD
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To the Editor—COVID-19 Vaccine and Postural Orthostatic Tachycardia Syndrome Heart Rhythm (IF 5.5) Pub Date : 2024-02-13 Hinpetch Daungsupawong PhD, Viroj Wiwanitkit MD
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Enhancing Transvenous Lead Extraction Risk Prediction: Integrating Imaging Biomarkers into Machine Learning Models Heart Rhythm (IF 5.5) Pub Date : 2024-02-12 Vishal S. Mehta, YingLiang Ma, Nadeev Wijesuriya, Felicity DeVere, Sandra Howell, Mark K. Elliott, Nilanka N. Mannkakara, Tatiana Hamakarim, Tom Wong, Hugh O’Brien, Steven Niederer, Reza Razavi, Christopher A. Rinaldi
Machine learning (ML) models have been proposed to predict risk related to transvenous lead extraction (TLE). We tested if integrating imaging data into an existing ML model increases its ability to predict major adverse events (MAE: procedure-related major complications and procedure-related deaths) and lengthy procedures (≥100 minutes). We hypothesised certain features: i) lead angulation ii) coil
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Defining the blanking period, using continuous ECG monitoring, after cryoballoon pulmonary vein isolation Heart Rhythm (IF 5.5) Pub Date : 2024-02-11 Dan L. Musat MD, Nicolle S. Milstein MS, Matthew Saberito MS, Advay Bhatt MD, Mohammadali Habibi MD, Tina C. Sichrovsky MD, Mark W. Preminger MD, Richard E. Shaw PhD, Suneet Mittal MD
Pulmonary vein isolation (PVI) is the cornerstone of atrial fibrillation (AF) ablation. A blanking period (BP) of 3 months is used in clinical trials and practice. However, the optimal BP duration after PVI remains undefined. The aim of this study was to objectively define, using continuous monitoring by an implantable loop recorder, the optimal BP duration after cryoballoon PVI. We enrolled consecutive
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Caudal tilt ultrasound: Are things looking up for axillary vein access? Heart Rhythm (IF 5.5) Pub Date : 2024-02-09 Anand Thiyagarajah MBBS, Dennis H. Lau MBBS PhD FHRS
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Electrocardiographic features that militate against early hospital discharge after transcatheter aortic valve replacement Heart Rhythm (IF 5.5) Pub Date : 2024-02-09 Oren Yagel MD, Jeremy Ben-Shoshan MD, Bernard Belhassen MD
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Sex-specific outcomes after catheter ablation in persistent AF Heart Rhythm (IF 5.5) Pub Date : 2024-02-08 Louise Segan MBBS, David Chieng MBBS PhD, Rose Crowley MBBS, Jeremy William MBBS, Hariharan Sugumar MBBS PhD, Liang-Han Ling MBBS PhD, Joshua Hawson MBBS, Sandeep Prabhu MBBS PhD, Aleksandr Voskoboinik MBBS PhD, Joseph B. Morton MBBS PhD, Geoffrey Lee MBChD PhD, Laurence D. Sterns MD, Matthew Ginks BSc MBBS MD, Prashanthan Sanders MBBS PhD, Jonathan M. Kalman MBBS PhD, Peter M. Kistler MBBS PhD
Sex-specific outcomes after catheter ablation (CA) for atrial fibrillation (AF) have reported conflicting findings. We examined the impact of female sex on outcomes in patients with persistent AF (PsAF) from the CAPLA randomized trial. A total of 338 patients with PsAF were randomized to pulmonary vein isolation (PVI) or PVI with posterior wall isolation (PWI). The primary outcome was arrhythmia recurrence
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Predictive value of the PRAETORIAN score for defibrillation test success in patients with subcutaneous ICD: A subanalysis of the PRAETORIAN-DFT trial Heart Rhythm (IF 5.5) Pub Date : 2024-02-08 Reinoud E. Knops MD PhD, Mikhael F. El-Chami MD, Christelle Marquie MD, Peter Nordbeck MD, Anne-Floor B.E. Quast MD PhD, Roland.R. Tilz MD PhD, Tom F. Brouwer MD PhD, Pier D. Lambiase MD PhD, Christopher J. Cassidy MD, Lucas V.A. Boersma MD PhD, Martin C. Burke DO, Shari Pepplinkhuizen MD, Jolien A. de Veld MD, Anouk de Weger MSc, Frank A.L.E. Bracke MD PhD, Harish Manyam MD, Vincent Probst MD PhD
The PRAETORIAN score estimates the risk of failure of subcutaneous implantable cardioverter-defibrillator (S-ICD) therapy by using generator and lead positioning on bidirectional chest radiographs. The PRAETORIAN-DFT trial investigates whether PRAETORIAN score calculation is noninferior to defibrillation testing (DFT) with regard to first shock efficacy in spontaneous events. This prespecified subanalysis
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Duration of atrial fibrillation: How much is too much? Heart Rhythm (IF 5.5) Pub Date : 2024-02-08 Peter Calvert MBChB, Mark T. Mills MBChB, Dhiraj Gupta MD
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Pulsed field ablation for atrial fibrillation in real-life settings: Efficacy, safety, and lesion durability in patients with recurrences Heart Rhythm (IF 5.5) Pub Date : 2024-02-08 Karim Benali MD, Konstantinos Vlachos MD, Vivek Y. Reddy MD PhD, Atul Verma MD PhD, Julian Chun MD PhD, Jason Andrade MD PhD, Laurent Macle MD PhD, Antoine Da Costa MD PhD, Pierre Jaïs MD PhD, Mélèze Hocini MD PhD
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Bipolar endo-epicardial RF ablation: Animal feasibility study Heart Rhythm (IF 5.5) Pub Date : 2024-02-08 Paweł Derejko MD PhD, Izabela Janus DVM PhD, Piotr Kułakowski MD PhD, Jacek Kuśnierz MD, Jakub Baran MD PhD, Urszula Hangiel MSc MPH, Joanna Proszek MSc, Piotr Frydrychowski DVM, Marcin Michałek DVM PhD, Agnieszka Noszczyk-Nowak DVM PhD
Bipolar radiofrequency ablation (B-RFA) is a method used to treat the arrhythmia substrate resistant to unipolar ablation. Few studies have addressed endo-epicardial B-RFA. The aim of the study was to evaluate chronic lesions resulting from endo-epicardial B-RFA and to determine optimal settings for such procedures in an animal model. In 7 pigs, up to 5 radiofrequency applications per animal were performed
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Association between daytime napping and incident arrhythmias: A prospective cohort study and mendelian randomization analysis Heart Rhythm (IF 5.5) Pub Date : 2024-02-08 Qing-Yuan Gao PhD, Hai-Feng Zhang PhD, Jing-Wei Gao PhD, Jie-Wen Cai BA, Qian Chen PhD, Si You BA, Zhi-Teng Chen MD, Da-Chuan Guo BA, Shu-Tai Li BA, Qing-Yun Hao MSc, Pin-Ming Liu PhD, Jing-Feng Wang PhD, Yang-Xin Chen PhD
Emerging evidence has linked daytime napping with the risk of cardiovascular events. Cardiac arrhythmias are considered an early clinical stage for cardiovascular diseases. However, whether napping frequency is associated with incident arrhythmias remains unknown. This study aimed to prospectively investigate the association between napping frequency and cardiac arrhythmias. Daytime napping frequency
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Adeno-associated virus–mediated gene therapy for cardiac tachyarrhythmia: A systematic review and meta-analysis Heart Rhythm (IF 5.5) Pub Date : 2024-02-07 Juan Mundisugih MBBS, Saurabh Kumar MBBS PhD, Eddy Kizana MBBS PhD
Cardiac tachyarrhythmia presents a significant health care challenge, causing notable morbidity and mortality. Conventional treatments have limitations and potential risks, resulting in an elevated disease burden. Adeno-associated virus (AAV)–mediated gene therapy holds promise as a potential future treatment option. Therefore, we aimed to provide a measured overview of the latest developments in this
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Polygenic risk scores in atrial fibrillation: Associations and clinical utility in disease prediction Heart Rhythm (IF 5.5) Pub Date : 2024-02-07 Joel T. Gibson BSc (Hons) MPhil, James H.F. Rudd MB BCh PhD FRCP FESC
Atrial fibrillation (AF) is a common heart arrhythmia and a major cause of cardioembolic stroke. Therefore, accurate prediction is desirable to allow high-risk individuals to be identified early and their risk lowered before complications arise. Polygenic risk scores (PRSs) have become a popular method of quantifying aggregated genetic risk from common variants, but their clinical value in AF remains