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The reproducibility of breathing maneuvers as a vasoactive stimulus in the heart: an oxygenation-sensitive resonance imaging study J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-12-27 Elizabeth Hillier, Jason Covone, Matthias G. Friedrich
Endothelial dysfunction and impaired oxygenation of the heart is a hallmark of several diseases, including coronary artery disease, hypertension, diabetes, and sleep apnea. Recent studies indicate that oxygenation-sensitive cardiovascular magnetic resonance (OS-CMR) imaging combined with breathing maneuvers may allow for assessing coronary vascular responsiveness as a marker for coronary vascular function
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Combining generative modelling and semi-supervised domain adaptation for whole heart cardiovascular magnetic resonance angiography segmentation J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-12-20 Marica Muffoletto, Hao Xu, Karl P. Kunze, Radhouene Neji, René Botnar, Claudia Prieto, Daniel Rückert, Alistair A. Young
Quantification of three-dimensional (3D) cardiac anatomy is important for the evaluation of cardiovascular diseases. Changes in anatomy are indicative of remodeling processes as the heart tissue adapts to disease. Although robust segmentation methods exist for computed tomography angiography (CTA), few methods exist for whole-heart cardiovascular magnetic resonance angiograms (CMRA) which are more
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Cardiac magnetic resonance in histologically proven eosinophilic myocarditis J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-12-18 Pauli Pöyhönen, Johanna Rågback, Mikko I. Mäyränpää, Hanna-Kaisa Nordenswan, Jukka Lehtonen, Chetan Shenoy, Markku Kupari
Eosinophilic myocarditis (EM) is a life-threatening acute heart disease. Cardiac magnetic resonance (CMR) excels in the assessment of myocardial diseases but CMR studies of EM are limited. We aimed to describe CMR findings in histologically proven EM. Patients with histologically proven EM seen at an academic center from 2000 through 2020 were identified. Of the 28 patients ascertained, 15 had undergone
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Cardiac structure discontinuities revealed by ex-vivo microstructural characterization. A focus on the basal inferoseptal left ventricle region J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-12-14 Pierre Cabanis, Julie Magat, Jairo Rodriguez-Padilla, Girish Ramlugun, Maxime Yon, Yann Bihan-Poudec, Nestor Pallares-Lupon, Fanny Vaillant, Philippe Pasdois, Pierre Jais, Pierre Dos-Santos, Marion Constantin, David Benoist, Line Pourtau, Virginie Dubes, Julien Rogier, Louis Labrousse, Michel Haissaguerre, Olivier Bernus, Bruno Quesson, Richard Walton, Josselin Duchateau, Edward Vigmond, Valéry Ozenne
While the microstructure of the left ventricle (LV) has been largely described, only a few studies investigated the right ventricular insertion point (RVIP). It was accepted that the aggregate cardiomyocytes organization was much more complex due to the intersection of the ventricular cavities but a precise structural characterization in the human heart was lacking even if clinical phenotypes related
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Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate CMR evaluated in an oral glucose challenge J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-12-14 Peder E. Z. Larson, Shuyu Tang, Xiaoxi Liu, Avantika Sinha, Nicholas Dwork, Sanjay Sivalokanathan, Jing Liu, Robert Bok, Karen G. Ordovas, James Slater, Jeremy W. Gordon, M. Roselle Abraham
The heart has metabolic flexibility, which is influenced by fed/fasting states, and pathologies such as myocardial ischemia and hypertrophic cardiomyopathy (HCM). Hyperpolarized (HP) 13C-pyruvate MRI is a promising new tool for non-invasive quantification of myocardial glycolytic and Krebs cycle flux. However, human studies of HP 13C-MRI have yet to demonstrate regional quantification of metabolism
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Incremental prognostic value of left atrial and biventricular feature tracking in dilated cardiomyopathy: a long-term study J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-12-07 Xiaorui Xiang, Yanyan Song, Kankan Zhao, Shiqin Yu, Shujuan Yang, Jing Xu, Jiaxin Wang, Zhixiang Dong, Xuan Ma, Zhuxin Wei, Yun Tang, Minjie Lu, Shihua Zhao, Xiuyu Chen
Despite the use of cardiovascular magnetic resonance (CMR) feature tracking (FT) imaging to detect myocardial deformation, the optimal strain index in dilated cardiomyopathy (DCM) is unclear. This study aimed to determine whether atrial and biventricular strains can provide the greatest or joint incremental prognostic value in patients with DCM over a long follow-up period. Four hundred-twelve DCM
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Effect of concomitant atrial septal defect on left ventricular function in adult patients with unrepaired Ebstein’s anomaly: a cardiovascular magnetic resonance imaging study J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-12-07 Xi Liu, Yue Gao, Zhen Wang, Rui Shi, Wen-Lei Qian, Meng-Ting Shen, Ying-Shi Sun, Zhi-Gang Yang
Due to the heterogeneity of anatomic anomalies in Ebstein’s anomaly (EA), particularly in the subset of patients with atrial septal defect (ASD), hemodynamic changes, which ultimately cause left ventricular (LV) deterioration remain unclear. The current study aimed to investigate the effect of concomitant ASD on LV function using cardiovascular magnetic resonance (CMR) imaging in patients with EA.
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Post-COVID-19 vaccination myocarditis: a prospective cohort study pre and post vaccination using cardiovascular magnetic resonance J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-12-07 Ming-Yen Ng, Cheuk Hang Tam, Yung Pok Lee, Ho Tung Ambrose Fong, Chun-Ka Wong, Wing Kei Carol Ng, Maegan Hon Yan Yeung, Wood-Hay Ian Ling, Sabrina Tsao, Eric Yuk Fai Wan, Vanessa Ferreira, Andrew T. Yan, Chung Wah Siu, Kai-Hang Yiu, Ivan Fan-Ngai Hung
Concerns about COVID-19 vaccination induced myocarditis or subclinical myocarditis persists in some populations. Cardiac magnetic resonance imaging (CMR) has been used to detect signs of COVID-19 vaccination induced myocarditis. This study aims to: (i) characterise myocardial tissue, function, size before and after COVID-19 vaccination, (ii) determine if there is imaging evidence of subclinical myocardial
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Technical development and feasibility of a reusable vest to integrate cardiovascular magnetic resonance with electrocardiographic imaging J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-12-04 Matthew Webber, George Joy, Jonathan Bennett, Fiona Chan, Debbie Falconer, Hunain Shiwani, Rhodri H. Davies, Gunther Krausz, Slobodan Tanackovic, Christoph Guger, Pablo Gonzalez, Emma Martin, Andrew Wong, Alicja Rapala, Kenan Direk, Peter Kellman, Iain Pierce, Yoram Rudy, Ramya Vijayakumar, Nishi Chaturvedi, Alun D. Hughes, James C. Moon, Pier D. Lambiase, Xuyuan Tao, Vladan Koncar, Michele Orini,
Electrocardiographic imaging (ECGI) generates electrophysiological (EP) biomarkers while cardiovascular magnetic resonance (CMR) imaging provides data about myocardial structure, function and tissue substrate. Combining this information in one examination is desirable but requires an affordable, reusable, and high-throughput solution. We therefore developed the CMR-ECGI vest and carried out this technical
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Ringlike late gadolinium enhancement provides incremental prognostic value in non-classical arrhythmogenic cardiomyopathy J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-11-30 Yuelong Yang, Xiaoyu Wei, Guanyu Lu, Jiajun Xie, Zekun Tan, Zhicheng Du, Weitao Ye, Huanwen Xu, Xiaodan Li, Entao Liu, Qianhuan Zhang, Yang Liu, Jinglei Li, Hui Liu
The 2019 arrhythmogenic right ventricular cardiomyopathy (ARVC) risk model has proved insufficient in the capability of predicting ventricular arrhythmia (VA) risk in non-classical arrhythmogenic cardiomyopathy (ACM). Furthermore, the prognostic value of ringlike late gadolinium enhancement (LGE) of the left ventricle in non-classical ACM remains unknown. We aimed to assess the incremental value of
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Left atrial expansion index measured with cardiovascular magnetic resonance estimates pulmonary capillary wedge pressure in dilated cardiomyopathy J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-11-30 Davide Genovese, Laura De Michieli, Giacomo Prete, Manuel De Lazzari, Marco Previtero, Donato Mele, Carlo Cernetti, Giuseppe Tarantini, Sabino Iliceto, Martina Perazzolo Marra
Pulmonary capillary wedge pressure (PCWP) assessment is fundamental for managing dilated cardiomyopathy (DCM) patients. Although cardiovascular magnetic resonance (CMR) has become the gold-standard imaging technique for evaluating cardiac chamber volume and function, PCWP is not routinely assessed with CMR. Therefore, this study aimed to validate the left atrial expansion index (LAEI), a LA reservoir
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Early reverse remodeling of left heart morphology and function evaluated by cardiac magnetic resonance in hypertrophic obstructive cardiomyopathy after transapical beating-heart septal myectomy J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-11-27 Yun Zhao, Chenhe Li, Dazhong Tang, Yi Luo, Chunlin Xiang, Lu Huang, Xiaoyue Zhou, Jing Fang, Xiang Wei, Liming Xia
This study aimed to evaluate the early morphology and function of the left heart in hypertrophic obstructive cardiomyopathy (HOCM) after transapical beating-heart septal myectomy (TA-BSM) using cardiovascular magnetic resonance (CMR). Between April 2022 and January 2023, HOCM patients who underwent CMR before and 3 months after TA-BSM were prospectively and consecutively enrolled in the study. Preoperative
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The Nottingham Ischaemic Cardiovascular Magnetic Resonance resource (NotIs CMR): a prospective paired clinical and imaging scar database—protocol J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-11-27 Nikesh Jathanna, Kevin Strachan, Bara Erhayiem, Hazlyna Kamaruddin, Peter Swoboda, Dorothee Auer, Xin Chen, Shahnaz Jamil-Copley
Research utilising artificial intelligence (AI) and cardiovascular magnetic resonance (CMR) is rapidly evolving with various objectives, however AI model development, generalisation and performance may be hindered by availability of robust training datasets including contrast enhanced images. NotIs CMR is a large UK, prospective, multicentre, observational cohort study to guide the development of a
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A dual-stage partially interpretable neural network for joint suppression of bSSFP banding and flow artifacts in non-phase-cycled cine imaging J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-11-23 Zhuo Chen, Sha Hua, Juan Gao, Yanjia Chen, Yiwen Gong, Yiwen Shen, Xin Tang, Yixin Emu, Wei Jin, Chenxi Hu
To develop a partially interpretable neural network for joint suppression of banding and flow artifacts in non-phase-cycled bSSFP cine imaging. A dual-stage neural network consisting of a voxel-identification (VI) sub-network and artifact-suppression (AS) sub-network is proposed. The VI sub-network provides identification of artifacts, which guides artifact suppression and improves interpretability
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A clinical strategy to improve the diagnostic performance of 3T non-contrast coronary MRA and noninvasively evaluate coronary distensibility: combination of diastole and systole imaging J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-11-23 Hongfei Lu, Shihai Zhao, Di Tian, Yinyin Chen, Jianying Ma, Meiying Ge, Mengsu Zeng, Hang Jin
The clinical application of coronary MR angiography (MRA) combining diastole and systole imaging has never been described comprehensively in coronary artery disease (CAD) patients. We aimed to design an optimal non-contrast coronary MRA scan protocol combining diastolic and systolic imaging and to (1) evaluate its diagnostic performance for detecting significant coronary stenosis; (2) evaluate the
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Ventricular dyssynchrony late after the Fontan operation is associated with decreased survival J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-11-20 Addison Gearhart, Sunakshi Bassi, Rahul H. Rathod, Rebecca S. Beroukhim, Stuart Lipsitz, Maxwell P. Gold, David M. Harrild, Audrey Dionne, Sunil J. Ghelani
Ventricular dyssynchrony and its relationship to clinical outcomes is not well characterized in patients following Fontan palliation. Single-center retrospective analysis of cardiac magnetic resonance (CMR) imaging of patients with a Fontan circulation and an age-matched healthy comparison cohort as controls. Feature tracking was performed on all slices of a ventricular short-axis cine stack. Circumferential
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Challenges and opportunities for early career medical professionals in cardiovascular magnetic resonance (CMR) imaging: a white paper from the Society for Cardiovascular Magnetic Resonance J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-11-16 Purvi Parwani, Tiffany Chen, Bradley Allen, Kimberly Kallianos, Ming-Yen Ng, Rebecca Kozor, Olukayode O. Aremu, Kanwal M. Farooqi, Aurelio Secinaro, Fabrizio Ricci, Sarah Moharem-Elgamal, Gabriela Liberato, Akhil Narang, Vineeta Ojha, Chiara Bucciarelli Ducci, Sven Plein, Karen G. Ordovas
The early career professionals in the field of Cardiovascular Magnetic Resonance (CMR) face unique challenges and hurdles while establishing their careers in the field. The Society for Cardiovascular Magnetic Resonance (SCMR) has expanded the role of the early career section within the society to foster the careers of future CMR leaders. This paper aims to describe the obstacles and available opportunities
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Reference ranges of myocardial T1 and T2 mapping in healthy Chinese adults: a multicenter 3T cardiovascular magnetic resonance study J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-11-16 Ziqian Xu, Weihao Li, Jiaqi Wang, Fei Wang, Bin Sun, Shifeng Xiang, Xiao Luo, Yanfeng Meng, Xiang Wang, Ximing Wang, Jianxun Song, Min Zhang, Dinghu Xu, Xiaoyue Zhou, Zhiguo Ju, Jiayu Sun, Yuchi Han, Yucheng Chen
Although reference ranges of T1 and T2 mapping are well established for cardiovascular magnetic resonance (CMR) at 1.5T, data for 3T are still lacking. The objective of this study is to establish reference ranges of myocardial T1 and T2 based on a large multicenter cohort of healthy Chinese adults at 3T CMR. A total of 1015 healthy Chinese adults (515 men, age range: 19–87 years) from 11 medical centers
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Free-breathing simultaneous native myocardial T1, T2 and T1ρ mapping with Cartesian acquisition and dictionary matching J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-11-09 Zhenfeng Lyu, Sha Hua, Jian Xu, Yiwen Shen, Rui Guo, Peng Hu, Haikun Qi
T1, T2 and T1ρ are well-recognized parameters for quantitative cardiac MRI. Simultaneous estimation of these parameters allows for comprehensive myocardial tissue characterization, such as myocardial fibrosis and edema. However, conventional techniques either quantify the parameters individually with separate breath-hold acquisitions, which may result in unregistered parameter maps, or estimate multiple
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Effect of etelcalcetide versus alfacalcidol on left ventricular function and feature-tracking cardiac magnetic resonance imaging in hemodialysis—a post-hoc analysis of a randomized, controlled trial J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-11-06 Katharina Dörr, Andreas Kammerlander, Francesco Lauriero, Matthias Lorenz, Rodrig Marculescu, Dietrich Beitzke
Calcimimetic therapy with etelcalcetide (ETEL) has been shown to attenuate the advancement of left ventricular (LV) hypertrophy in hemodialysis patients measured by cardiac magnetic resonance (CMR). The aim of the study was to evaluate whether this effect is accompanied by alterations in LV function and myocardial composition. This was a post-hoc analysis of a randomized-controlled trial of ETEL versus
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Late-gadolinium enhancement is common in older pediatric heart transplant recipients and is associated with lower ejection fraction J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-11-06 Andrew A. Lawson, Kae Watanabe, Lindsay Griffin, Christina Laternser, Michael Markl, Cynthia K. Rigsby, Melanie Sojka, Joshua D. Robinson, Nazia Husain
Chronic graft failure and cumulative rejection history in pediatric heart transplant recipients (PHTR) are associated with myocardial fibrosis on endomyocardial biopsy (EMB). Cardiovascular magnetic resonance imaging (CMR) is a validated, non-invasive method to detect myocardial fibrosis via the presence of late gadolinium enhancement (LGE). In adult heart transplant recipients, LGE is associated with
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Differences in blood flow dynamics between balloon- and self-expandable valves in patients with aortic stenosis undergoing transcatheter aortic valve replacement J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-10-26 Yuki Takahashi, Kiwamu Kamiya, Toshiyuki Nagai, Satonori Tsuneta, Noriko Oyama-Manabe, Takeshi Hamaya, Sho Kazui, Yutaro Yasui, Kohei Saiin, Seiichiro Naito, Yoshifumi Mizuguchi, Sakae Takenaka, Atsushi Tada, Suguru Ishizaka, Yuta Kobayashi, Kazunori Omote, Takuma Sato, Yasushige Shingu, Kohsuke Kudo, Satoru Wakasa, Toshihisa Anzai
The differences in pre- and early post-procedural blood flow dynamics between the two major types of bioprosthetic valves, the balloon-expandable valve (BEV) and self-expandable valve (SEV), in patients with aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR), have not been investigated. We aimed to investigate the differences in blood flow dynamics between the BEV and SEV
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Society for Cardiovascular Magnetic Resonance perspective on the ACC/AHA/ASE/ASNC/ASPC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2023 multi-modality appropriate use criteria for the detection and risk assessment of chronic coronary disease J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-10-19 W. Patricia Bandettini, Raymond Y. Kwong, Amit R. Patel, Sven Plein
The American College of Cardiology, together with other specialty and subspecialty societies, has recently published Appropriate Use Criteria (AUC) for the Detection and Risk Assessment of Chronic Coronary Disease (CCD) [1]. The document updates the 2013 AUC for the management of Stable Ischemic Heart Disease (SIHD) [2] and covers the use of radionuclide imaging, stress echocardiography (echo), coronary
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ACC/AHA/ASE/ASNC/ASPC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2023 Multimodality Appropriate Use Criteria for the Detection and Risk Assessment of Chronic Coronary Disease J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-10-19 David E. Winchester, David J. Maron, Ron Blankstein, Ian C. Chang, Ajay J. Kirtane, Raymond Y. Kwong, Patricia A. Pellikka, Jordan M. Prutkin, Raymond Russell, Alexander T. Sandhu
The American College of Cardiology (ACC) Foundation, along with key specialty and subspecialty societies, conducted an appropriate use review of stress testing and anatomic diagnostic procedures for risk assessment and evaluation of known or suspected chronic coronary disease (CCD), formerly referred to as stable ischemic heart disease (SIHD). This document reflects an updating of the prior Appropriate
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Association of pulmonary transit time by cardiac magnetic resonance with heart failure hospitalization in a large prospective cohort with diverse cardiac conditions J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-10-12 J. Jane Cao, Niloofar Fouladi Nashta, Jonathan Weber, Ruqiyya Bano, Michael Passick, Y. Joshua Cheng, William Schapiro, Marie Grgas, Kathleen Gliganic
Longer pulmonary transit time (PTT) is closely associated with hemodynamic abnormalities. However, the implications on heart failure (HF) risk have not been investigated broadly in patients with diverse cardiac conditions. In this study we examined the long-term risk of HF hospitalization associated with longer PTT in a large prospective cohort with a broad spectrum of cardiac conditions. All subjects
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Quantitative assessment of angioplasty-induced vascular inflammation with 19F cardiovascular magnetic resonance imaging J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-10-03 Fabian Nienhaus, Moritz Walz, Maik Rothe, Annika Jahn, Susanne Pfeiler, Lucas Busch, Manuel Stern, Christian Heiss, Lilian Vornholz, Sandra Cames, Mareike Cramer, Vera Schrauwen-Hinderling, Norbert Gerdes, Sebastian Temme, Michael Roden, Ulrich Flögel, Malte Kelm, Florian Bönner
Macrophages play a pivotal role in vascular inflammation and predict cardiovascular complications. Fluorine-19 magnetic resonance imaging (19F MRI) with intravenously applied perfluorocarbon allows a background-free direct quantification of macrophage abundance in experimental vascular disease models in mice. Recently, perfluorooctyl bromide-nanoemulsion (PFOB-NE) was applied to effectively image macrophage
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Highly accelerated free-breathing real-time myocardial tagging for exercise cardiovascular magnetic resonance J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-10-02 Manuel A. Morales, Siyeop Yoon, Ahmed Fahmy, Fahime Ghanbari, Shiro Nakamori, Jennifer Rodriguez, Jennifer Yue, Jordan A. Street, Daniel A. Herzka, Warren J. Manning, Reza Nezafat
Exercise cardiovascular magnetic resonance (Ex-CMR) myocardial tagging would enable quantification of myocardial deformation after exercise. However, current electrocardiogram (ECG)-segmented sequences are limited for Ex-CMR. We developed a highly accelerated balanced steady-state free-precession real-time tagging technique for 3 T. A 12-fold acceleration was achieved using incoherent sixfold random
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Integration of longitudinal and circumferential strain predicts volumetric change across the cardiac cycle and differentiates patients along the heart failure continuum J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-10-02 T. Jake Samuel, Andrew P. Oneglia, Daisha J. Cipher, Justin A. Ezekowitz, Jason R. B. Dyck, Todd Anderson, Jonathan G. Howlett, D. Ian Paterson, Richard B. Thompson, Michael D. Nelson
Left ventricular (LV) circumferential and longitudinal strain provide important insight into LV mechanics and function, each contributing to volumetric changes throughout the cardiac cycle. We sought to explore this strain-volume relationship in more detail, by mathematically integrating circumferential and longitudinal strain and strain rate to predict LV volume and volumetric rates of change. Cardiac
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Automated detection of cardiac rest period for trigger delay calculation for image-based navigator coronary magnetic resonance angiography J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-10-02 Gregory Wood, Alexandra Uglebjerg Pedersen, Karl P. Kunze, Radhouene Neji, Reza Hajhosseiny, Jens Wetzl, Seung Su Yoon, Michaela Schmidt, Bjarne Linde Nørgaard, Claudia Prieto, René M. Botnar, Won Yong Kim
Coronary magnetic resonance angiography (coronary MRA) is increasingly being considered as a clinically viable method to investigate coronary artery disease (CAD). Accurate determination of the trigger delay to place the acquisition window within the quiescent part of the cardiac cycle is critical for coronary MRA in order to reduce cardiac motion. This is currently reliant on operator-led decision
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Potential of non-contrast stress T1 mapping for the assessment of myocardial injury in hypertrophic cardiomyopathy J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-09-28 Hisanori Kosuge, Shoko Hachiya, Yasuhiro Fujita, Satoshi Hida, Taishiro Chikamori
Ischemia of the hypertrophied myocardium due to microvascular dysfunction is related to a worse prognosis in hypertrophic cardiomyopathy (HCM). Stress and rest T1 mapping without contrast agents can be used to assess myocardial blood flow. Herein, we evaluated the potential of non-contrast stress T1 mapping in assessing myocardial injury in patients with HCM. Forty-five consecutive subjects (31 HCM
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Cardiac magnetic resonance parameters associated with successful conversion from a single ventricular to a one-and-a-half or biventricular circulation in patients with a hypoplastic right ventricle J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-09-28 Deepa Prasad, Jennifer Romanowicz, Puja Banka, Rebecca Beroukhim, Sunil J. Ghelani, Sitaram Emani, Andrew J. Powell
Some patients with pulmonary atresia with an intact ventricular septum (PA/IVS) or a left ventricle dominant atrioventricular canal defect (LDAVC) with a hypoplastic right ventricle (RV) and univentricular (1 V) circulation may be candidates for conversion to either a complete biventricular (2 V) repair or a one-and-a-half ventricle repair (1.5 V). We sought to identify pre-operative cardiovascular
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Age- and sex-specific reference values of biventricular flow components and kinetic energy by 4D flow cardiovascular magnetic resonance in healthy subjects J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-09-18 Xiaodan Zhao, Ru-San Tan, Pankaj Garg, Ping Chai, Shuang Leng, Jennifer Ann Bryant, Lynette L. S. Teo, Tee Joo Yeo, Marielle V. Fortier, Ting Ting Low, Ching Ching Ong, Shuo Zhang, Rob J. Van der Geest, John C. Allen, Teng Hong Tan, James W. Yip, Ju Le Tan, Marina Hughes, Sven Plein, Jos J. M. Westenberg, Liang Zhong
Advances in four-dimensional flow cardiovascular magnetic resonance (4D flow CMR) have allowed quantification of left ventricular (LV) and right ventricular (RV) blood flow. We aimed to (1) investigate age and sex differences of 4D flow CMR-derived LV and RV relative flow components and kinetic energy (KE) parameters indexed to end-diastolic volume (KEiEDV) in healthy subjects; and (2) assess the effects
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Hemodynamic forces from 4D flow magnetic resonance imaging predict left ventricular remodeling following cardiac resynchronization therapy J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-08-25 Karin Pola, Anders Roijer, Rasmus Borgquist, Ellen Ostenfeld, Marcus Carlsson, Zoltan Bakos, Håkan Arheden, Per M. Arvidsson
Patients with heart failure and left bundle branch block (LBBB) may receive cardiac resynchronization therapy (CRT), but current selection criteria are imprecise, and many patients have limited treatment response. Hemodynamic forces (HDF) have been suggested as a marker for CRT response. The aim of this study was therefore to investigate left ventricular (LV) HDF as a predictive marker for LV remodeling
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Predictive value of cardiac magnetic resonance right ventricular longitudinal strain in patients with suspected myocarditis J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-08-17 Benedikt Bernhard, Giulin Tanner, Davide Garachemani, Aaron Schnyder, Kady Fischer, Adrian T. Huber, Yasaman Safarkhanlo, Anselm W. Stark, Dominik P. Guensch, Jonathan Schütze, Simon Greulich, Jessica A. M. Bastiaansen, Maryam Pavlicek-Bahlo, Dominik C. Benz, Raymond Y. Kwong, Christoph Gräni
Recent evidence underlined the importance of right (RV) involvement in suspected myocarditis. We aim to analyze the possible incremental prognostic value from RV global longitudinal strain (GLS) by CMR. Patients referred for CMR, meeting clinical criteria for suspected myocarditis and no other cardiomyopathy were enrolled in a dual-center register cohort study. Ejection fraction (EF), GLS and tissue
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Interventional cardiovascular magnetic resonance: state-of-the-art J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-08-14 Toby Rogers, Adrienne E. Campbell-Washburn, Rajiv Ramasawmy, D. Korel Yildirim, Christopher G. Bruce, Laurie P. Grant, Annette M. Stine, Aravindan Kolandaivelu, Daniel A. Herzka, Kanishka Ratnayaka, Robert J. Lederman
Transcatheter cardiovascular interventions increasingly rely on advanced imaging. X-ray fluoroscopy provides excellent visualization of catheters and devices, but poor visualization of anatomy. In contrast, magnetic resonance imaging (MRI) provides excellent visualization of anatomy and can generate real-time imaging with frame rates similar to X-ray fluoroscopy. Realization of MRI as a primary imaging
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Multi-site comparison of parametric T1 and T2 mapping: healthy travelling volunteers in the Berlin research network for cardiovascular magnetic resonance (BER-CMR) J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-08-14 Jan Gröschel, Ralf-Felix Trauzeddel, Maximilian Müller, Florian von Knobelsdorff-Brenkenhoff, Darian Viezzer, Thomas Hadler, Edyta Blaszczyk, Elias Daud, Jeanette Schulz-Menger
Parametric mapping sequences in cardiovascular magnetic resonance (CMR) allow for non-invasive myocardial tissue characterization. However quantitative myocardial mapping is still limited by the need for local reference values. Confounders, such as field strength, vendors and sequences, make intersite comparisons challenging. This exploratory study aims to assess whether multi-site studies that control
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Modeling of factors affecting late gadolinium enhancement kinetics in MRI of cardiac amyloid J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-08-10 Leon Axel
Late gadolinium enhancement (LGE) is a valuable part of cardiac magnetic resonance imaging (CMR). In particular, inversion-recovery imaging of LGE, with nulling of the signal from reference areas of myocardium, can have a distinctive pattern in some patients with cardiac amyloid, including both diffuse (relatively faint) subendocardial LGE and a relatively dark appearance of the blood. However, the
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Comprehensive cardiac magnetic resonance T1, T2, and extracellular volume mapping to define Duchenne cardiomyopathy J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-07-31 Sudeep D. Sunthankar, Kristen George-Durrett, Kimberly Crum, James C. Slaughter, Jennifer Kasten, Frank J. Raucci, Larry W. Markham, Jonathan H. Soslow
Cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD). Cardiac magnetic resonance (CMR) parametric mapping sequences offer insights into disease pathophysiology. We propose a novel approach by leveraging T2 mapping in conjunction with T1 and extracellular volume (ECV) mapping to perform a virtual myocardial biopsy. While previous work has attempted to describe myocardial
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Cardiac reverse remodeling in primary mitral regurgitation: mitral valve replacement vs. mitral valve repair J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-07-27 Thomas P. Craven, Pei G. Chew, Laura E. Dobson, Miroslawa Gorecka, Martine Parent, Louise A. E. Brown, Christopher E. D. Saunderson, Arka Das, Amrit Chowdhary, Nicholas Jex, David M. Higgins, Erica Dall’Armellina, Eylem Levelt, Dominik Schlosshan, Peter P. Swoboda, Sven Plein, John P. Greenwood
When feasible, guidelines recommend mitral valve repair (MVr) over mitral valve replacement (MVR) to treat primary mitral regurgitation (MR), based upon historic outcome studies and transthoracic echocardiography (TTE) reverse remodeling studies. Cardiovascular magnetic resonance (CMR) offers reference standard biventricular assessment with superior MR quantification compared to TTE. Using serial CMR
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Cardiovascular magnetic resonance in the guidelines of the European Society of Cardiology: a comprehensive summary and update J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-07-24 Florian von Knobelsdorff-Brenkenhoff, Jeanette Schulz-Menger
Cardiovascular magnetic resonance (CMR) has been established as a valuable tool in clinical and scientific cardiology. This study summarizes the current evidence and role of CMR in the guidelines of the European Society of Cardiology (ESC) and is an update of a former guideline analysis. Since the last guideline analysis performed in 2015, 28 new ESC guideline documents have been published. Twenty-seven
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Subtractionless compressed-sensing-accelerated whole-body MR angiography using two-point Dixon fat suppression with single-pass half-reduced contrast dose: feasibility study and initial experience J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-07-20 Qing Fu, Zi-qiao Lei, Jing-yang Li, Jia-wei Wu, Xiao-ming Liu, Wen-liang Fan, Peng Sun, Jia-zheng Wang, Ding-xi Liu, Fan Yang, Chuan-sheng Zheng, Xiang-chuang Kong
To investigate the feasibility and clinical utility of a compressed-sensing-accelerated subtractionless whole-body MRA (CS-WBMRA) protocol with only contrast injection for suspected arterial diseases, by comparison to conventional dual-pass subtraction-based whole-body MRA (conventional-WBMRA) and available computed tomography angiography (CTA). This prospective study assessed 86 patients (mean age
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4D Flow cardiovascular magnetic resonance consensus statement: 2023 update J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-07-20 Malenka M. Bissell, Francesca Raimondi, Lamia Ait Ali, Bradley D. Allen, Alex J. Barker, Ann Bolger, Nicholas Burris, Carl-Johan Carhäll, Jeremy D. Collins, Tino Ebbers, Christopher J. Francois, Alex Frydrychowicz, Pankaj Garg, Julia Geiger, Hojin Ha, Anja Hennemuth, Michael D. Hope, Albert Hsiao, Kevin Johnson, Sebastian Kozerke, Liliana E. Ma, Michael Markl, Duarte Martins, Marci Messina, Thekla
Hemodynamic assessment is an integral part of the diagnosis and management of cardiovascular disease. Four-dimensional cardiovascular magnetic resonance flow imaging (4D Flow CMR) allows comprehensive and accurate assessment of flow in a single acquisition. This consensus paper is an update from the 2015 ‘4D Flow CMR Consensus Statement’. We elaborate on 4D Flow CMR sequence options and imaging considerations
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Ventricular global function index is associated with clinical outcomes in pediatric pulmonary hypertension J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-07-03 Hieu T. Ta, Paul J. Critser, Michal Schäfer, Nicholas J. Ollberding, Michael D. Taylor, Michael V. Di Maria, Russel Hirsch, D. Dunbar Ivy, Benjamin S. Frank
Multiple right ventricular (RV) metrics have prognostic value in pulmonary hypertension (PH). A cardiac magnetic resonance imaging (CMR) derived global ventricular function index (GFI) provided improved prediction of composite adverse outcome (CAO) in adults with atherosclerosis. GFI has not yet been explored in a PH population. We explored the feasibility of GFI as a predictor of CAO in a pediatric
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Worldwide variation in cardiovascular magnetic resonance practice models J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-07-03 Lilia M. Sierra-Galan, Edgar E. S. Estrada-Lopez, Victor A. Ferrari, Subha V. Raman, Vanessa M. Ferreira, Vimaj Raj, Elizabeth Joseph, Jeanette Schulz-Menger, Carmen W. S. Chan, Sylvia S. M. Chen, Yuchen Cheng, Juliano De Lara Fernandez, Masahiro Terashima, Timothy S. E. Albert
The use of cardiovascular magnetic resonance (CMR) for diagnosis and management of a broad range of cardiac and vascular conditions has quickly expanded worldwide. It is essential to understand how CMR is utilized in different regions around the world and the potential practice differences between high-volume and low-volume centers. CMR practitioners and developers from around the world were electronically
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Diagnostic accuracy of whole heart coronary magnetic resonance angiography: a systematic review and meta-analysis J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-06-26 Shingo Kato, Mai Azuma, Naoki Nakayama, Kazuki Fukui, Masanori Ito, Naka Saito, Nobuyuki Horita, Daisuke Utsunomiya
The purpose of this meta-analysis was to comprehensively investigate the diagnostic ability of 1.5 T and 3.0 T whole heart coronary angiography (WHCA) to detect significant coronary artery disease (CAD) on X-ray coronary angiography. A literature search of electronic databases, including PubMed, Web of Science Core Collection, Cochrane advanced search, and EMBASE, was performed to retrieve and integrate
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Multiparametric mapping by cardiovascular magnetic resonance imaging in cardiac tumors J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-06-22 Pengfei Yue, Ziqian Xu, Ke Wan, Yinxi Tan, Yuanwei Xu, Xiaotong Xie, David Mui, Cheng Yi, Yuchi Han, Yucheng Chen
There is a paucity of quantitative measurements of cardiac tumors and myocardium using parametric mapping techniques. This study aims to explore quantitative characteristics and diagnostic performance of native T1, T2, and extracellular volume (ECV) values of cardiac tumors and left ventricular (LV) myocardium. Patients with suspected cardiac tumors who underwent cardiovascular magnetic resonance (CMR)
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A simplified method to correct saturation of arterial input function for cardiac magnetic resonance first-pass perfusion imaging: validation with simultaneously acquired PET J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-06-22 Ran Li, Masoud Edalati, David Muccigrosso, Jeffrey M. C. Lau, Richard Laforest, Pamela K. Woodard, Jie Zheng
First-pass perfusion imaging in magnetic resonance imaging (MRI) is an established method to measure myocardial blood flow (MBF). An obstacle for accurate quantification of MBF is the saturation of blood pool signal intensity used for arterial input function (AIF). The objective of this project was to validate a new simplified method for AIF estimation obtained from single-bolus and single sequence
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Magnetic resonance myocardial T1ρ mapping J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-06-19 Aurelien Bustin, Walter R. T. Witschey, Ruud B. van Heeswijk, Hubert Cochet, Matthias Stuber
The potential of cardiac magnetic resonance to improve cardiovascular care and patient management is considerable. Myocardial T1-rho (T1ρ) mapping, in particular, has emerged as a promising biomarker for quantifying myocardial injuries without exogenous contrast agents. Its potential as a contrast-agent-free (“needle-free”) and cost-effective diagnostic marker promises high impact both in terms of
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Cardiac MRI-based right-to-left ventricular blood pool T2 relaxation times ratio correlates with exercise capacity in patients with chronic heart failure J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-06-19 Moritz C. Halfmann, Lukas Müller, Urs von Henning, Roman Kloeckner, Theresia Schöler, Karl-Friedrich Kreitner, Christoph Düber, Philip Wenzel, Akos Varga-Szemes, Sebastian Göbel, Tilman Emrich
MRI T2 mapping has been proven to be sensitive to the level of blood oxygenation. We hypothesized that impaired exercise capacity in chronic heart failure is associated with a greater difference between right (RV) to left ventricular (LV) blood pool T2 relaxation times due to a higher level of peripheral blood desaturation, compared to patients with preserved exercise capacity and to healthy controls
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Additional value of cardiac magnetic resonance feature tracking parameters for the evaluation of the arrhythmic risk in patients with mitral valve prolapse J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-06-15 Marco Guglielmo, Dimitri Arangalage, Marco Augusto Bonino, Gianmarco Angelini, Michela Bonanni, Gianluca Pontone, Patrizio Pascale, Laura Anna Leo, Francesco Faletra, Jurg Schwitter, Giovanni Pedrazzini, Pierre Monney, Anna Giulia Pavon
The identification of patients with mitral valve prolapse (MVP) presenting high arrhythmic risk remains challenging. Cardiovascular Magnetic Resonance (CMR) feature tracking (FT) may improve risk stratification. We analyzed the role of CMR-FT parameters in relation to the incidence of complex ventricular arrhythmias (cVA) in patients with MVP and mitral annular disjunction (MAD). 42 patients with MVP
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Comparison of aortic stiffness and hypertension in repaired coarctation patients with a bicuspid versus a tricuspid aortic valve J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-06-15 Kwannapas Saengsin, Kimberlee Gauvreau, Ashwin Prakash
Coarctation of the aorta (COA) is associated with reduced aortic distensibility and systemic hypertension (HTN). 60–85% of COA patients have a bicuspid aortic valve (BAV). It is not known if the presence of a BAV accentuates the aortopathy and HTN in CoA patients. We examined whether patients with COA and a BAV had lower aortic distensibility by CMR, and a higher prevalence of systemic HTN compared
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Reference data for left ventricular filling and atrial function in children using cardiovascular magnetic resonance J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-06-12 Christopher C. Henderson, Kristen George-Durrett, Sandra Kikano, James C. Slaughter, Joshua D. Chew, David Parra, Jeffrey Weiner, Jonathan Soslow
Diastolic dysfunction is associated with morbidity and mortality in multiple pediatric disease processes. Cardiovascular magnetic resonance (CMR) provides a non-invasive method of studying left ventricular (LV) diastolic dysfunction through the assessment of LV filling curves and left atrial (LA) volume and function. However, there are no normative data for LV filling curves and the standard method
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Safety and incremental prognostic value of stress cardiovascular magnetic resonance in patients with known chronic kidney disease J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-06-12 Théo Pezel, Thierry Unterseeh, Thomas Hovasse, Francesca Sanguineti, Philippe Garot, Stéphane Champagne, Solenn Toupin, Tania Ah-Sing, Alyssa Faradji, Martin Nicol, Lounis Hamzi, Jean Guillaume Dillinger, Patrick Henry, Valérie Bousson, Jérôme Garot
Cardiovascular disease (CVD) is the main cause of mortality in patients with chronic kidney disease (CKD). Although several studies have demonstrated the consistently high prognostic value of stress cardiovascular magnetic resonance (CMR), its prognostic value in patients with CKD is not well established. We aimed to assess the safety and the incremental prognostic value of vasodilator stress perfusion
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Magnetic resonance three-dimensional steady-state free precession imaging of the thoracic duct in patients with Fontan circulation and its relationship to outcomes J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-06-12 Daniel A. Castellanos, Sidra Ahmad, Nicole St. Clair, Lynn A. Sleeper, Minmin Lu, David N. Schidlow, Rahul H. Rathod, Suellen M. Yin, Jesse J. Esch, David Annese, Andrew J. Powell, Luis Quiñonez, Raja Shaikh, Sunil J. Ghelani
Lymphatic complications are common in patients with Fontan circulation. Three-dimensional balanced steady-state free precession (3D bSSFP) angiography by cardiovascular magnetic resonance (CMR) is widely used for cardiovascular anatomical assessment. We sought to determine the frequency of thoracic duct (TD) visualization using 3D bSSFP images and assess whether TD characteristics are associated with
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Editorial Expression of Concern: Splenic T1-mapping: a novel quantitative method for assessing adenosine stress adequacy for cardiovascular magnetic resonance J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-05-25 Alexander Liu, Rohan S. Wijesurendra, Rina Ariga, Masliza Mahmod, Eylem Levelt, Andreas Greiser, Mario Petrou, George Krasopoulos, John C. Forfar, Rajesh K. Kharbanda, Keith M. Channon, Stefan Neubauer, Stefan K. Piechnik, Vanessa M. Ferreira
Editorial Expression of Concern: Journal of Cardiovascular Magnetic Resonance (2017) 19:1 https://doi.org/10.1186/s12968-016-0318-2 The Editor-in-Chief would like to alert readers that concerns have been raised regarding the data in this article. Authors Vanessa M. Ferreira, Stefan K. Piechnik and Stefan Neubauer reached out to the Journal of Cardiovascular Magnetic Resonance in MO YEAR to report that
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Normative ranges of biventricular volumes and function in healthy term newborns J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-04-24 Simone Jhaveri, Ellie Battersby, Kenan W. D. Stern, Jennifer Cohen, Yang Yang, Anthony Price, Emer Hughes, Lucilla Poston, Dharmintra Pasupathy, Paul Taylor, Matias C. Vieira, Alan Groves
Cardiovascular magnetic resonance (CMR) is increasingly used in newborns with congenital heart disease. However, reporting on ventricular volumes and mass is hindered by an absence of normative data in this population. Healthy term (37–41 weeks gestation) newborns underwent non-sedated, free-breathing CMR within the first week of life using the ‘feed and wrap’ technique. End-diastolic volume (EDV)
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MRXCAT2.0: Synthesis of realistic numerical phantoms by combining left-ventricular shape learning, biophysical simulations and tissue texture generation J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-04-20 Stefano Buoso, Thomas Joyce, Nico Schulthess, Sebastian Kozerke
Standardised performance assessment of image acquisition, reconstruction and processing methods is limited by the absence of images paired with ground truth reference values. To this end, we propose MRXCAT2.0 to generate synthetic data, covering healthy and pathological function, using a biophysical model. We exemplify the approach by generating cardiovascular magnetic resonance (CMR) images of healthy
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Cardiovascular magnetic resonance-derived left atrioventricular coupling index and major adverse cardiac events in patients following acute myocardial infarction J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-04-13 Torben Lange, Sören J. Backhaus, Alexander Schulz, Ruben Evertz, Johannes T. Kowallick, Boris Bigalke, Gerd Hasenfuß, Holger Thiele, Thomas Stiermaier, Ingo Eitel, Andreas Schuster
Recently, a novel left atrioventricular coupling index (LACI) has been introduced providing prognostic value to predict cardiovascular events beyond common risk factors in patients without cardiovascular disease. Since data on cardiovascular magnetic resonance (CMR)-derived LACI in patients following acute myocardial infarction (AMI) are scarce, we aimed to assess the diagnostic and prognostic implications
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The incomplete circle of Willis is associated with vulnerable intracranial plaque features and acute ischemic stroke J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-04-06 Huiying Wang, Lianfang Shen, Chenxi Zhao, Song Liu, Gemuer Wu, Huapeng Wang, Beini Wang, Jinxia Zhu, Jixiang Du, Zhongying Gong, Chao Chai, Shuang Xia
The circle of Willis (CoW) plays a significant role in intracranial atherosclerosis (ICAS). This study investigated the relationship between different types of CoW, atherosclerosis plaque features, and acute ischemic stroke (AIS). We investigated 97 participants with AIS or transient ischemic attacks (TIA) underwent pre- and post-contrast 3T vessel wall cardiovascular magnetic resonance within 7 days
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Automated segmentation of long and short axis DENSE cardiovascular magnetic resonance for myocardial strain analysis using spatio-temporal convolutional neural networks J. Cardiovasc. Magn. Reson. (IF 6.4) Pub Date : 2023-03-30 Hugo Barbaroux, Karl P. Kunze, Radhouene Neji, Muhummad Sohaib Nazir, Dudley J. Pennell, Sonia Nielles-Vallespin, Andrew D. Scott, Alistair A. Young
Cine Displacement Encoding with Stimulated Echoes (DENSE) facilitates the quantification of myocardial deformation, by encoding tissue displacements in the cardiovascular magnetic resonance (CMR) image phase, from which myocardial strain can be estimated with high accuracy and reproducibility. Current methods for analyzing DENSE images still heavily rely on user input, making this process time-consuming