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Pupil reflex as a marker of activity and prognosis in heart failure: a longitudinal and prospective study Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-17 Margarita Zamorano, Juan Manuel Monteagudo, Eduardo González, Isabel Rayo, Sara Fernández, Miguel Castillo, Qiheng Zhou, Pedro de la Villa, Jose Luis Zamorano
Compensatory mechanisms in heart failure (HF) are triggered to maintain adequate cardiac output. Among them, hyperactivation of the sympathetic nervous system (SNS) is one of the main ones and carries a worse prognosis. The pupillary reflex depends on the SNS, and we can evaluate it through pupillometry. The aim of the study was to compare the differences in pupillary reflex between patients with acute
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Obesity: the perfect storm for heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-16 Maria Lembo, Teresa Strisciuglio, Celeste Fonderico, Costantino Mancusi, Raffaele Izzo, Valentina Trimarco, Alessandro Bellis, Emanuele Barbato, Giovanni Esposito, Carmine Morisco, Speranza Rubattu
Obesity condition causes morphological and functional alterations involving the cardiovascular system. These can represent the substrates for different cardiovascular diseases, such as atrial fibrillation, coronary artery disease, sudden cardiac death, and heart failure (HF) with both preserved ejection fraction (EF) and reduced EF. Different pathogenetic mechanisms may help to explain the association
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Socio‐economic position, multimorbidity, and health care utilization among Danish left ventricular assist device patients Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-16 Inge Schjødt, Rikke E. Mols, István Bakos, Erzsébet Horváth‐Puhó, Finn Gustafsson, Søren L. Kristensen, Johan E. Larsson, Bo Christensen, Hans Eiskjær, Brian B. Løgstrup
AimsIncreasing numbers of patients with advanced heart failure and significant comorbidity and social barriers are considered for left ventricular assist devices (LVADs). We sought to examine health care utilization post‐LVAD implantation, including the influence of individual‐level socio‐economic position and multimorbidity.Methods and resultsWe conducted a Danish nationwide cohort study linking individual‐level
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Optimal combination of right ventricular functional parameters using echocardiography in pulmonary arterial hypertension Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-16 Qimou Li, Yu Zhang, Xiaopei Cui, Weida Lu, Qiushang Ji, Mei Zhang
AimsNovel echocardiographic parameters of right ventricular (RV) function, including speckle‐tracking‐derived, three‐dimensional, and RV–pulmonary artery coupling parameters, have emerged for the evaluation of pulmonary arterial hypertension (PAH). The relative role of these parameters in the risk stratification of PAH patients is unclear. We compared the performance of multiple RV parameters and sought
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Correction to “Impedance‐based remote monitoring in patients with heart failure and concomitant chronic kidney disease” Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-16
Wintrich, J, Pavlicek, V, Brachmann, J, Bosch, R, Butter, C, Oswald, H, Rybak, K, Mahfoud, F, Böhm, M, Ukena, C. Impedance-based remote monitoring in patients with heart failure and concomitant chronic kidney disease. ESC Heart Fail 2023; 10: 3011–3018.10.1002/ehf2.14387 The below funding statement for this article was missing: Open Access funding enabled and organized by Projekt DEAL.
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Impact of epicardial adipose tissue on cardiac function and morphology in patients with diastolic dysfunction Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-14 Alexander Schulz, Sören J. Backhaus, Torben Lange, Ruben Evertz, Shelby Kutty, Johannes T. Kowallick, Gerd Hasenfuß, Andreas Schuster
AimsThis study aimed to identify the impact of increased epicardial adipose tissue (EAT) and its regional distribution on cardiac function in patients with diastolic dysfunction.Methods and resultsSixty‐eight patients with exertional dyspnoea (New York Heart Association ≥II), preserved ejection fraction (≥50%), and diastolic dysfunction (E/e′ ≥ 8) underwent rest and stress right heart catheterization
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Systemic sclerosis is associated with increased in‐patient mortality in patients hospitalized for heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-13 Akil A. Sherif, Vinit J. Gilvaz, Sonu Abraham, Anu Mariam Saji, Don Mathew, Ameesh Isath, Aiswarya Rajendran, Johanna Contreras, Gregg M. Lanier, Anthony M. Reginato
AimsWe aimed to analyse the characteristics and in‐hospital outcomes of patients hospitalized for heart failure (HF) with co‐morbid systemic sclerosis (SSc) and compare them to those without SSc, using data from the National Inpatient Sample from years 2016 to 2019.Methods and resultsInternational Classification of Diseases, Tenth Revision diagnosis codes were used to identify hospitalized patients
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Renal ultrasonography predicts worsening renal function in patients with heart failure under tolvaptan administration Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-12 Nobukiyo Tanaka, Yoshio Furukawa, Takuya Maeda, Hiroki Ishihara, Kazuhiro Dan, Masanori Teramura, Kei Ichihashi, Tetsuro Takase, Yuya Takahashi, Daichi Tsuzura, Akira Shinoda, Masato Fujii, Hisashi Okada, Fumiharu Itabashi, Tomohiko Teramoto
AimsRenal dysfunction in patients with chronic heart failure predicts a poor prognosis. Tolvaptan has a diuretic effect in patients with chronic kidney disease and heart failure without adverse effects on renal function. We aimed to determine the effects of tolvaptan and predictors of worsening renal function in patients with heart failure.Methods and resultsThis post hoc analysis was a sub‐analysis
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U‐shaped association between serum calcium and in‐hospital mortality in patients with congestive heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-12 Kai Zhang, Yu Han, Tianyi Cai, Fangming Gu, Zhaoxuan Gu, JiaYu Zhao, Jianguo Chen, Bowen Chen, Min Gao, Zhengyan Hou, Xiaoqi Yu, Yafang Gao, Rui Hu, Jinyu Xie, Tianzhou Liu, MaoXun Huang
AimsSerum calcium level is widely used for evaluating disease severity, but its impact on clinical outcomes in patients with congestive heart failure (CHF) remains poorly understood. The aim of this study is to investigate the relationship between serum calcium levels and in‐hospital mortality in CHF patients.Methods and resultsWe conducted a retrospective analysis utilizing clinical data from the
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Immediate pharmacotherapy intensification after cardiac resynchronization therapy: incidence, characteristics, and impact Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-12 Kojiro Ogawa, Hiro Yamasaki, Kazutaka Aonuma, Masafumi Otani, Ai Hattori, Masako Baba, Kentaro Yoshida, Miyako Igarashi, Hidetaka Nishina, Kou Suzuki, Akihiko Nogami, Masaki Ieda
AimsCardiac resynchronization therapy (CRT) is an established treatment for drug‐refractory heart failure (HF) in patients with left bundle branch block (LBBB). Acute haemodynamic improvement after CRT implantation may enable the intensification of HF medication soon thereafter. Immediate pharmacotherapy intensification (IPI) after CRT implantation achieves a synergetic effect, possibly leading to
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Histopathology of congestive nephropathy: a case description and literature review Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-12 Faeq Husain‐Syed, Janani Rangaswami, Julio Núñez, Susanne Skrzypek, Christian Jux, Hermann‐Josef Gröne, Horst‐Walter Birk
Congestive nephropathy is an underappreciated manifestation of cardiorenal syndrome and is characterized by a potentially reversible kidney dysfunction caused by a reduced renal venous outflow secondary to right‐sided heart failure or intra‐abdominal hypertension. To date, the histological diagnostic criteria for congestive nephropathy have not been defined. We herein report a case of acute renal dysfunction
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Low-density lipoprotein cholesterol, erythrocyte, and platelet in heart failure with preserved ejection fraction Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-08 Masamichi Yano, Masami Nishino, Shodai Kawanami, Kohei Ukita, Akito Kawamura, Koji Yasumoto, Masaki Tsuda, Naotaka Okamoto, Yasuharu Matsunaga-Lee, Yasuyuki Egami, Takahisa Yamada, Yoshio Yasumura, Masahiro Seo, Takaharu Hayashi, Akito Nakagawa, Yusuke Nakagawa, Shunsuke Tamaki, Yohei Sotomi, Daisaku Nakatani, Shungo Hikoso, Yasushi Sakata
Low-density lipoprotein cholesterol (LDL-C), anaemia and low platelets have been associated with worse clinical outcomes in heart failure patients. We investigated the relationship between the combination of these three components and clinical outcome in patients with heart failure with preserved ejection fraction (HFpEF).
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Excess renin is attributed to the combination of forward and backward failure in HFrEF Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-09 Henrike Arfsten, Gregor Heitzinger, Suriya Prausmüller, Annika Weidenhammer, Georg Goliasch, Philipp E. Bartko, Georg Spinka, Martin Hülsmann, Noemi Pavo
AimsRegulation of the renin‐angiotensin system (RAS) in heart failure (HF) with reduced ejection fraction (HFrEF) still raises questions, as a large proportion of patients show normal renin levels despite manifest disease. Experimental venous congestion results in reduced renal perfusion pressure and stimulates renin secretion. We hypothesized that excess renin levels are mainly a result of right ventricular
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Translating the ‘shunt fraction’ method to derive native cardiac output during VA ECMO support Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-09 Hoong Sern Lim
I am grateful to Bachmann and colleagues for taking the time to read and comment on my work1, 2 Indeed, it was remiss of me not to have cited their contributions to this subject.3 I will address three points that Bachmann and colleagues have raised in their Letter. Firstly, the ‘generalized solution’ described by Bachmann and colleagues is a logical mathematical derivation of the Fick principle, which
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Identification of molecular signatures in epicardial adipose tissue in heart failure with preserved ejection fraction Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-08 Shan He, Lei Zhao, Jianjun Zhang, Xinchun Yang, Huagang Zhu
AimsThe molecular signatures in epicardial adipose tissue (EAT) that contribute to the pathogenesis of heart failure with preserved ejection fraction (HFpEF) are poorly characterized. In this study, we sought to elucidate molecular signatures including genetic transcripts and long non‐coding RNAs (lncRNAs) in EAT that might modulate HFpEF development.MethodsRNA sequencing (RNA‐seq) was performed to
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Loop diuretic down‐titration at discharge in patients hospitalized for acute heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-08 François Croset, Pau Llàcer, Julio Núñez, Jorge Campos, Marina García, Alberto Pérez, Cristina Fernández, Martín Fabregate, Genoveva López, Susana Tello, José María Fernández, Raúl Ruiz, Luis Manzano
AimsThe current literature provides limited guidance on the best diuretic strategy post‐hospitalization for acute heart failure (AHF). It is postulated that the efficacy and safety of the outpatient diuretic regimen may be significantly influenced by the degree of fluid overload (FO) encountered during hospitalization. We hypothesize that in patients with more pronounced FO, reducing their regular
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Effects of pharmacological interventions on mortality in patients with Takotsubo syndrome: a report from the SWEDEHEART registry Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-08 Petur Petursson, Eduard Oštarijaš, Björn Redfors, Truls Råmunddal, Oskar Angerås, Sebastian Völz, Araz Rawshani, Kristina Hambraeus, Sasha Koul, Joakim Alfredsson, Henrik Hagström, Henareh Loghman, Robin Hofmann, Ole Fröbert, Tomas Jernberg, Stefan James, David Erlinge, Elmir Omerovic
AimsTakotsubo syndrome (TS) is a heart condition mimicking acute myocardial infarction. TS is characterized by a sudden weakening of the heart muscle, usually triggered by physical or emotional stress. In this study, we aimed to investigate the effect of pharmacological interventions on short‐ and long‐term mortality in patients with TS.Methods and resultsWe analysed data from the SWEDEHEART (the Swedish
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Prevalence and prognostic impact of bone disease in chronic heart failure with reduced ejection fraction Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-07 Nicolas Verheyen, Johannes Schmid, Ewald Kolesnik, Nora Schwegel, Johannes Späth, Lydia Kattnig, Hermann Riepl, David Zach, Viktoria Santner, Viktoria Höller, Stefan Pilz, Andreas Tomaschitz, Michael Fuchsjäger, Astrid Fahrleitner‐Pammer, Hans Peter Dimai, Barbara Obermayer‐Pietsch, Friedrich Fruhwald, Daniel Scherr, Andreas Zirlik, Dirk von Lewinski, Klemens Ablasser
AimsChronic heart failure is associated with a bone‐catabolic state and increases the risk of osteoporosis and fractures. Prospective studies investigating the clinical relevance of bone disease in heart failure are lacking. We aimed to assess the prevalence and prognostic impact of osteoporosis and vertebral fractures (VFs) in chronic heart failure with reduced ejection fraction (HFrEF).Methods and
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Prognostic mortality factors in advanced light chain cardiac amyloidosis: A prospective cohort study Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-06 Amira Zaroui, Mounira Kharoubi, Romain Gounot, Silvia Oghina, Charlotte Degoutte, Melanie Bezard, Arnault Galat, Soulef Guendouz, Louise Roulin, Vincent Audard, Vincent Leroy, Emmanuel Teiger, Elsa Poullot, Valérie Molinier‐Frenkel, Fabien Le Bras, Karim Belhadj, Jean‐Philippe Bastard, Soraya Fellahi, Jason Shourick, Francois Lemonier, Thibaud Damy
AimsPredicting mortality in severe AL cardiac amyloidosis is challenging due to elevated biomarker levels and limited thresholds for stratifying severe cardiac damage.Methods and resultsThis prospective, observational, cohort study included de novo, confirmed cardiac AL amyloidosis patients at the Henri Mondor National Reference Centre. The goal was to identify predictors of mortality to enhance prognostic
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Epicardial adipose tissue and pericardial constraint in heart failure with preserved ejection fraction Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-04 Yoran Crum, Elke S. Hoendermis, Dirk J. van Veldhuisen, Gijs van Woerden, Michelle Lobeek, Michael G. Dickinson, Laura M.G. Meems, Adriaan A. Voors, Michiel Rienstra, Thomas M. Gorter
Obesity and epicardial adiposity play a role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF), and both are associated with increased filling pressures and reduced exercise capacity. The haemodynamic basis for these observations remains inaccurately defined. We hypothesize that an abundance of epicardial adipose tissue (EAT) within the pericardial sac is associated with
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Epidemiology and risk factors for hyperkalaemia in heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-05 Diederick E. Grobbee, Gerasimos Filippatos, Nihar R. Desai, Andrew J. S. Coats, Fausto Pinto, Giuseppe M. C. Rosano, John G. F. Cleland, Jennifer Kammerer, Antonio Ramirez de Arellano
Patients with heart failure (HF), particularly those with impaired renal function receiving renin–angiotensin–aldosterone system inhibitors (RAASis), are at risk of hyperkalaemia; when hyperkalaemia is severe, this can have serious clinical consequences. The incidence, prevalence, and risk factors for hyperkalaemia reported in randomized trials of RAASis may not reflect clinical practice due to exclusion
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Adherence to heart failure treatment in patients with peripartum cardiomyopathy Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-05 Julian Hoevelmann, Karen Sliwa, Juel Maalouli Schaar, Olivia Briton, Michael Böhm, Markus R. Meyer, Charle Viljoen
AimsPeripartum cardiomyopathy (PPCM) is characterized by left ventricular (LV) dysfunction developing towards the end of pregnancy or in the first months postpartum. Although about 60% of women with PPCM (the majority of which are prescribed evidence based heart failure [HF] medications) show LV recovery within 6 to 12 months, others remain with persistently impaired LV function. Poor adherence to
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Development and validation of algorithms to predict left ventricular ejection fraction class from healthcare claims data Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-05 Damien Logeart, Maxime Doublet, Margaux Gouysse, Thibaud Damy, Richard Isnard, François Roubille
AimsThe use of large medical or healthcare claims databases is very useful for population‐based studies on the burden of heart failure (HF). Clinical characteristics and management of HF patients differ according to categories of left ventricular ejection fraction (LVEF), but this information is often missing in such databases. We aimed to develop and validate algorithms to identify LVEF in healthcare
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Prognostic significance of growth differentiation factor-15 across age in chronic heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-01 Kanako Teramoto, Kotaro Nochioka, Yasuhiko Sakata, Kunihiro Nishimura, Hiroaki Shimokawa, Satoshi Yasuda
Growth differentiation factor-15 (GDF15), a cytokine in the transforming growth factor family, is up-regulated in stress and inflammatory conditions and is elevated in patients with heart failure (HF). However, the age-specific attributes and prognostic significance of GDF15 across age remain unknown in chronic HF (CHF).
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Reply to: ‘Non‐invasively assessed hemodynamics in patients with high flow arteriovenous fistula and high output cardiac failure’ Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-01 Dan‐Ying Lee, Wei‐Chieh Huang, Cheng‐Hsueh Wu, Chih‐Yu Yang
In response: We would like to thank Dr Kristína Burýšková Salajová et al. for their comments on our article. We have carefully read through all suggestions and made necessary responses based on these comments. In the method section, high output cardiac failure (HOCF) hospitalization was defined as symptomatic HF (stage C or D) with a high output status [cardiac output (CO) value > 8 or cardiac index
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Comparison of cardiovascular outcomes of new antihyperglycemic agents in Type 2 Diabetes Mellitus: a meta‐analysis Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-29 Zijing Zhou, Min Zheng, Zhihong Zuo, Ting Wu
AimsThe study aims to provide comprehensive evidence for the selection of agents in type 2 diabetes mellitus (T2DM) patients with cardiovascular risk and summarize the lasted evidence for the cardiovascular effects of sodium glucose cotransporter‐2 inhibitor (SGLT2i) in patients with heart failure (HF).Methods and resultsSeveral online databases were searched. All studies that explored the cardiovascular
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Effect of levosimendan on ventricular remodelling in patients with left ventricular systolic dysfunction: a meta‐analysis Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-29 Xia Wang, Xiu‐Zhi Zhao, Xi‐Wen Wang, Lu‐Ying Cao, Bin Lu, Zhi‐Hao Wang, Wei Zhang, Yun Ti, Ming Zhong
Heart failure is the final stage of several cardiovascular diseases, and the key to effectively treating heart failure is to reverse or delay ventricular remodelling. Levosimendan is a novel inotropic and vasodilator agent used in heart failure, whereas the impact of levosimendan on ventricular remodelling is still unclear. This study aims to investigate the impact of levosimendan on ventricular remodelling
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Blood perfusion status is important in the prognosis of ventricular aneurysm complicated by ventricular septal rupture Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-28 Siyuan Huang, Shicheng Zhang, Yangwu Song, Wei Feng
AimsDue to its low incidence, poor prognosis, and high mortality in the acute phase, the long‐term prognosis of the left ventricular aneurysm (LVA) complicated by ventricular septal rupture (VSR) has received little attention. This study focus on the long‐term prognosis of patients with LVA complicated by relatively stable VSR.Methods and resultsOver a decade of retrospection, 68 patients with both
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Editors' highlight picks from 2023 in ESC heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-27 Magnus Bäck, Stephan von Haehling, Zoltán Papp, Massimo F. Piepoli
Heart failure is a devastating syndrome affecting an increasingly high number of patients worldwide. Its aetiology and pathogenesis are complex with the involvement of factors ranging from the genetic material through valvular dysfunctions to numerous organs beyond the entire cardiovascular system. Based on continuous efforts of the heart failure scientific community we have witnessed major advances
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Histological assessment of cardiac amyloidosis in patients undergoing transcatheter aortic valve replacement Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-26 Bo Eric Beuthner, Manar Elkenani, Katja Evert, Julian Mustroph, Christoph Friedemann Jacob, Niels Benjamin Paul, Tim Beißbarth, Elisabeth Maria Zeisberg, Moritz Schnelle, Miriam Puls, Gerd Hasenfuß, Karl Toischer
AimsStudies have reported a strongly varying co‐prevalence of aortic stenosis (AS) and cardiac amyloidosis (CA). We sought to histologically determine the co‐prevalence of AS and CA in patients undergoing transcatheter aortic valve replacement (TAVR). Consequently, we aimed to derive an algorithm to identify cases in which to suspect the co‐prevalence of AS and CA.Methods and resultsIn this prospective
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Iron Deficiency and Incident Heart Failure in Older Community‐Dwelling Individuals Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-26 Shilpa Sharma, Ronit Katz, Paulo H.M. Chaves, Andrew N. Hoofnagle, Jorge R. Kizer, Nisha Bansal, Tomas Ganz, Joachim H. Ix
AimsAmong persons with prevalent heart failure (HF), iron deficiency has been linked to HF admissions, and intravenous iron replacement improves HF outcomes. Recent studies in persons with chronic kidney disease (CKD) demonstrate that iron deficiency is associated with incident HF. This study aimed to determine the relationship of iron status with incident HF in community‐dwelling older adults irrespective
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Subarachnoid haemorrhage‐induced reversible cardiac dysfunction: time course and potential mechanisms Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-24 Yichao Xiao, Xin Lai, Zhuo Wang, Songyun Wang, Zhihong Wu, Qiming Liu, Mingxian Chen, Shenghua Zhou
AimsCardiac dysfunction is commonly observed in patients with subarachnoid haemorrhage (SAH). However, the specific timeline of cardiac remodelling and the underlying mechanisms responsible for this effect following SAH remain unknown. This study aims to explore the impact of SAH on cardiac dysfunction and its potential mechanisms over time.Methods and resultsIn Protocol 1, we investigated cardiac
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A new staging system using right atrial strain in patients with immunoglobulin light‐chain cardiac amyloidosis Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-24 Hiroki Usuku, Eiichiro Yamamoto, Daisuke Sueta, Rumi Shinriki, Fumi Oike, Noriaki Tabata, Masanobu Ishii, Shinsuke Hanatani, Tadashi Hoshiyama, Hisanori Kanazawa, Yuichiro Arima, Seiji Takashio, Yawara Kawano, Seitaro Oda, Hiroaki Kawano, Mitsuharu Ueda, Kenichi Tsujita
AimsThere are minimal data on the prognostic impact of right atrial strain during the reservoir phase (RASr) in patients with immunoglobulin light‐chain (AL) cardiac amyloidosis.Methods and resultsAmong 78 patients who were diagnosed with AL cardiac amyloidosis at Kumamoto University Hospital from 2007 to 2022, 72 patients with sufficient two‐dimensional speckle tracking imaging data without chemotherapy
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Impact of the operative technique on mid- and long-term results following paediatric heart transplantation Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-20 L. Lily Rosenthal, Carola Grinninger, Robert Dalla Pozza, Marcus Fischer, Linda Zimmerling, Sarah M. Ulrich, Fabian A. Kari, Nikolaus A. Haas, Sebastian Michel, Jürgen Hörer, Christian Hagl
The aim of this study is to evaluate and compare the impact of the bicaval technique versus the biatrial technique (by Lower and Shumway) in paediatric heart transplant patients. Only a few studies investigate this matter regarding the long-term outcome after paediatric heart transplantation. We compared the two surgical methods regarding survival, the necessity of pacemaker implantation.
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Cardiac magnetic resonance imaging in heart transplant recipients with biopsy-negative graft dysfunction Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-20 Senthil Anand, Hilmi Alnsasra, Lisa M. LeMond, Sanskriti Shrivastava, Rabea Asleh, Andrew Rosenbaum, Semaan Kobrossi, Akanksha Mohananey, Katie Murphy, Byron H. Smith, Sudhir Kushwaha, David E. Steidley, Alfredo Clavell, Phillip Young, Naveen L. Pereira
Graft dysfunction (GD) after heart transplantation (HTx) can develop without evidence of cell- or antibody-mediated rejection. Cardiac magnetic resonance imaging (CMR) has an evolving role in detecting rejection; however, its role in biopsy-negative GD has not been described. This study examines CMR findings, evaluates outcomes based on CMR results, and seeks to identify the possibility of rejection
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Design and baseline characteristics of SALT‐HF trial: hypertonic saline therapy in ambulatory heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-21 M. Cobo Marcos, J. Comín‐Colet, R. de la Espriella, J. Rubio Gracia, J. L. Morales‐Rull, I. Zegrí, P. Llacer, P. Diez‐Villanueva, S. Jiménez‐Marrero, J. de Juan Bagudá, C. Ortiz Cortés, J. Goirigolzarri‐Artaza, J. M. García‐Pinilla, E. Barrios, S. del Prado Díaz, E. Montero Hernández, M. Sanchez‐Marteles, J. Nuñez
AimsHypertonic saline solution (HSS) plus intravenous (IV) loop diuretic appears to enhance the diuretic response in patients hospitalized for heart failure (HF). The efficacy and safety of this therapy in the ambulatory setting have not been evaluated. We aimed to describe the design and baseline characteristics of the SALT‐HF trial participants.Methods and results‘Efficacy of Saline Hypertonic Therapy
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Distinct myocardial triglyceride lipolysis pathways in primary and idiopathic triglyceride deposit cardiomyovasculopathy Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-18 Yoshihiko Ikeda, Mikio Shiba, Hiroyuki Yamamoto, Tomonori Itoh, Takahiro Okumura, Yusuke Nakano, Hideyuki Miyauchi, Tomomi Ide, Sohsuke Yamada, Hiroyuki Hao, Seiya Kato, Ken-ichi Hirano
Triglyceride (TG) is a major energy source for a normal heart. Myocardial lipolysis is a crucial step to hydrolyse TG and release long-chain fatty acid (LCFA) for mitochondrial β-oxidation to produce ATP. Therefore, it is of significance to elucidate its regulatory pathway(s) in order to understand pathophysiology of heart failure (HF). Triglyceride deposit cardiomyovasculopathy (TGCV) is a rare, emerging
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Heart failure during acute coronary syndrome and the long‐term cancer risk: the ABC‐9† Study on heart disease Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-20 Heba T. Mahmoud, Giuseppe Berton, Rocco Cordiano, Rosa Palmieri, David Merotto, Francesco Menegon
AimsA higher risk of cancer among patients with heart failure (HF) has been suggested in recent community‐based studies. This study aimed to investigate the impact of HF during hospitalization with acute coronary syndrome (ACS) on the long‐term cancer risk.Methods and resultsThe study included 572 patients admitted with ACS to three Italian hospitals, discharged cancer‐free, and prospectively followed
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Chlorogenic acid attenuates cardiac hypertrophy via up‐regulating Sphingosine‐1‐phosphate receptor1 to inhibit endoplasmic reticulum stress Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-19 Ping Ping, Ting Yang, Chaoxue Ning, Qingkai Zhao, Yali Zhao, Tao Yang, Zhitao Gao, Shihui Fu
AimsCardiac hypertrophy, an adaptive response of the heart to stress overload, is closely associated with heart failure and sudden cardiac death. This study aimed to investigate the therapeutic effects of chlorogenic acid (CGA) on cardiac hypertrophy and elucidate the underlying mechanisms.Methods and resultsTo simulate cardiac hypertrophy, myocardial cells were exposed to isoproterenol (ISO, 10 μM)
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Pregnancy and cardiac maternal outcomes in women with inherited cardiomyopathy: interest of the CARPREG II risk score Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-15 Thomas Wallet, Lise Legrand, Richard Isnard, Estelle Gandjbakhch, Françoise Pousset, Julie Proukhnitzky, Marc Dommergues, Jacky Nizard, Philippe Charron
Inherited cardiomyopathies are relatively rare but carry a high risk of cardiac maternal morbidity and mortality during pregnancy and postpartum. However, data for risk stratification are scarce. The new CARPREG II score improves prediction of prognosis in pregnancies associated with heart disease, though its role in inherited cardiomyopathies is unclear. We aim to describe characteristics and cardiac
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Tyrosine to threonine ratio was related to heart failure with reduced or mildly reduced ejection fraction Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-15 Qing Fen Zhou, Fan Yang, Yang Dai, Shuai Chen, Feng Ru Zhang, Lin Lu, Qiu Ya Lu
We aim to explore the associations between serum tyrosine (Tyr) to threonine (Thr) ratio and chronic heart failure (HF) with reduced or mildly reduced ejection fraction (EF) (HFrEF or HFmrEF).
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Prognostic impact of residual pulmonary congestion assessed by remote dielectric sensing system in patients admitted for heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-14 Toshihide Izumida, Teruhiko Imamura, Takatoshi Koi, Masaki Nakagaito, Hiroshi Onoda, Shuhei Tanaka, Ryuichi Ushijima, Naoya Kataoka, Makiko Nakamura, Mitsuo Sobajima, Nobuyuki Fukuda, Hiroshi Ueno, Koichiro Kinugawa
Remote dielectric sensing (ReDS) represents a contemporary non-invasive technique reliant on electromagnetic energy to quantify pulmonary congestion. Its prognostic significance within the context of heart failure (HF) patients remains elusive. This study aimed to assess the prognostic implications of residual pulmonary congestion, as gauged by the ReDS system, among patients admitted due to congestive
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Guideline-directed medical therapy assessment in heart failure patients undergoing percutaneous mitral valve repair Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-13 Karl-Patrik Kresoja, Marianna Adamo, Karl-Phillipp Rommel, Lukas Stolz, Nicole Karam, Cristina Giannini, Bruno Melica, Ralph Stephan von Bardeleben, Christian Butter, Patrick Horn, Fabien Praz, Daniel Kalbacher, Christos Iliadis, Holger Thiele, Jörg Hausleiter, Marco Metra, Philipp Lurz
Achieving optimized guideline-directed medical therapy (GDMT) is recommended prior to transcatheter mitral valve edge-to-edge repair (M-TEER) for secondary mitral regurgitation (SMR). We aimed to propose and validate an easy-to-use score for assessing the quality of GDMT in patients with heart failure with reduced ejection fraction (HFrEF) undergoing M-TEER.
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Tricuspid annular disjunction with varying degrees of tricuspid regurgitation in the setting of Takotsubo syndrome Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-13 Benjamin Gaylard, Angela Montaño-Krawczuk, Kristina Haugaa, Magnus Bäck
Tricuspid annular disjunction (TAD) is concomitant in approximately half of mitral annular disjunction (MAD) cases. Here we report a case of echocardiographically isolated TAD detected during Takotsubo syndrome (TTS) complicated by a transient aggravation of tricuspid regurgitation. An 87-year-old female was admitted at the emergency department with ST segment elevation. Coronary angiography findings
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Takotsubo syndrome and vaccines: a systematic review Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-12 Chenlin Li, Pengyang Li, Bharath Peddibhotla, Catherine Teng, Ao Shi, Xiaojia Lu, Peng Cai, Qiying Dai, Bin Wang
Takotsubo syndrome (TTS) is a rare complication of vaccination. In this study, we sought to provide insight into the characteristics of reported TTS induced by vaccination.
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Carbohydrate antigen 125: a useful marker of congestion, fibrosis, and prognosis in heart failure with preserved ejection fraction Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-09 Nassiba Menghoum, Maria Chiara Badii, Matthieu Deltombe, Sibille Lejeune, Clotilde Roy, David Vancraeynest, Agnes Pasquet, Bernhard L. Gerber, Sandrine Horman, Damien Gruson, Christophe Beauloye, Anne-Catherine Pouleur
Heart failure (HF) with preserved ejection fraction (HFpEF) is a disease associated with high morbidity and mortality, for which it is difficult to identify patients with the poorest prognosis in routine clinical practice. Carbohydrate antigen 125 (CA 125) has been shown to be a potential marker of congestion and prognosis in HF. We sought to better characterize HFpEF patients with high CA 125 levels
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Left ventricular unloading and venting in veno-arterial extracorporeal membrane oxygenation: the importance of cardiogenic shock aetiology in guiding treatment strategies Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-08 Luca Baldetti, Guglielmo Gallone
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) offers cardiorespiratory support to cardiogenic shock (CS) patients. However, VA-ECMO, especially in the most common peripheral configuration, comes with the drawback of heightened afterload on the left ventricle (LV), primarily attributable to retrograde aortic flow that pressurizes the systemic arterial circulation. When the failing LV is
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A novel likely pathogenic homozygous RBCK1 variant in dilated cardiomyopathy with muscle weakness Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-08 MohammadHossein MozafaryBazargany, Shiva Esmaeili, Mahshid Hesami, Golnaz Houshmand, Mohamad Mahdavi, Majid Maleki, Samira Kalayinia
Polyglucosan body myopathy 1 (PGBM1) is a type of glycogen storage disease where polyglucosan accumulation leads to cardiomyopathy and skeletal muscle myopathy. Variants of RBCK1 is related with PGBM1. We present a newly discovered pathogenic RBCK1 variant resulting in dilated cardiomyopathy (DCM) and a comprehensive literature review.
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S2I2N0–3 score predicts short- and long-term mortality and morbidity in HFrEF: a post-hoc analysis of the GUIDE-IT trial Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-07 Junyi Sun, Zhengshuo Xie, Min Ye, He Xu, Yugang Dong, Chen Liu, Wengen Zhu
This study investigated the S2I2N0–3 score, a simple tool comprising stroke history, insulin-treated diabetes, and N-terminal pro-brain natriuretic peptide, for forecasting mortality and morbidity in heart failure (HF) with reduced ejection fraction (HFrEF).
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Persistent convex ST-segment elevation in a patient with a history of prior intracerebral haemorrhage Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-06 Jian Jiang, Chengjiang Jin, Shuo Yu, Yunxian Cheng, Yinggang Wu, Hong Ma
Management of patients with acute chest pain poses a significant challenge in identifying those requiring urgent coronary reperfusion. Electrocardiogram (ECG) constitutes the cornerstone in making prompt clinical decisions by identifying ST-segment elevation, commonly associated with ST-segment elevation myocardial infarction. It is important to note that ST-segment elevation can also be a manifestation
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Investigating the relationship between FRailty And Quality of LIfe in patients with heart faiLure and CKD (FRAIL study) Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-06 Thomas McNally, Ella Tumelty, Isaac Chung, Sabba Hussain, Souradip Mookerjee, Mahrukh Ayesha Ali, Lisa Anderson, Giuseppe Rosano, Debasish Banerjee
Patients with chronic kidney disease (CKD) or heart failure (HF) are disproportionally affected by frailty, an independent predictor of morbidity. The prevalence of frailty and its impact on quality of life (QoL) in a unique population of patients with both CKD and HF (CKD-HF) is unclear. The aim of this study was to investigate the association between frailty and QoL in patients with CKD-HF.
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Diagnostic procedure for localized constrictive pericarditis leading to bilateral pleural effusion: two case reports Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-06 Shaowei Liu, Zhi Li, Naijian Li, Weifeng Wei, Xinyin Liang, Jinlin Wang
Constrictive pericarditis is a rare disease. Localized constrictive pericarditis leading to bilateral pleural effusion is more difficult to recognize, and the diagnostic procedure can be ambiguous. Here, we report two patients diagnosed with localized constrictive pericarditis who presented with bilateral pleural effusion. A thorough work-up showed that the pleural effusion was nonspecific, as was
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Survival outcomes of TAVR and self-expanding versus balloon-expandable valves in patients with advanced cardiac dysfunction Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-06 Anthony Matta, Thibault Lhermusier, Patrick Ohlmann, Levai Laszlo, Vanessa Nader, Francisco Campelo Parada, Meyer Elbaz, Jerome Roncalli, Didier Carrié
There is a growing body of literature on long-term outcomes post-transcatheter aortic valve replacement (TAVR), but to our knowledge, few research have focused on patients with advanced cardiac dysfunction. This challenging category of patients was excluded from the Partner 3 clinical trial. There are no data to guide the choice of valve type in patients with severely depressed ejection fraction. This
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Non-dilated left ventricular cardiomyopathy vs. dilated cardiomyopathy: clinical background and outcomes Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-06 Yuko Eda, Takeru Nabeta, Saeko Iikura, Yu Takigami, Teppei Fujita, Yuichiro Iida, Yuki Ikeda, Shunsuke Ishii, Junya Ako
Non-dilated left ventricular cardiomyopathy (NDLVC) was proposed as a new category of cardiomyopathy that included patients with non-left ventricular (LV) dilatation, LV wall motion abnormality, or LV scar. However, the clinical background and event rates of NDLVC were unclear. The aim of this study was to examine the characteristics and event rates of patients with NDLVC and reduced LV ejection fraction
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Narrative synthesis of the effectiveness and characteristics of heart failure disease self-management support programmes Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-04 Apinya Koontalay, Mari Botti, Anastasia Hutchinson
A deeper understanding of the key elements that should be included in heart failure (HF) disease self-management support (DSMS) programmes is crucial to enhance programme effectiveness and applicability to diverse settings. We investigated the characteristics and effectiveness of DSMS programmes designed to improve survival and decrease acute care readmissions for people with HF and determine the generalizability
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Heart failure outcomes by left ventricular ejection fraction in a contemporary region-wide patient cohort Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-04 Johan Sundström, Johan Ärnlöv, Stelios Karayiannides, Johan Bodegard, Karolina Ersmark, Stefan Gustafsson, Thomas Cars, Maria K. Svensson, Anna Norhammar
This study aimed to characterize a contemporary population with subtypes of incident or prevalent heart failure (HF) based on reduced (HFrEF), mildly reduced, or preserved (HFpEF) left ventricular ejection fraction (LVEF) and to assess how outcomes, healthcare, treatments, and healthcare costs vary between each subtype of incident HF.
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A prediction model for estimating NT-proBNP in a general Japanese population: the Toon Health Study Esc Heart Fail. (IF 3.8) Pub Date : 2024-02-01 Katsuji Inoue, Kazumichi Yamamoto, Haruhiko Higashi, Yasunori Takata, Shinji Inaba, Shigehiro Miyazaki, Akinori Higaki, Makoto Saito, Haruhiko Osawa, Osamu Yamaguchi
As part of the Toon Health Study, which is an ongoing population-based cohort study, we aimed to develop a prediction model for N-terminal pro-brain natriuretic peptide (NT-proBNP) in a general Japanese population. We sought to explore the influence of various demographic and clinical factors on NT-proBNP levels and assess the model's performance. In addition, our objectives included internal validation
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CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia–reperfusion injury via autophagic status Esc Heart Fail. (IF 3.8) Pub Date : 2024-01-30 Qin Liu, Guorong Lai, Yanhui Hu, Fan Yang, Chao Zhang, Dongsheng Le, Fumou Deng, Xianliang Xing, Binquan Tang, Huanhuan Jie, Yingping Liang, Enjun Lei
Acute myocardial infarction (MI) is a significant contributor to death in individuals diagnosed with coronary heart disease on a worldwide level. The specific mechanism by which circRbms1 contributes to the damage caused by myocardial ischaemia–reperfusion (I/R) is not well understood. The primary aim of this study was to examine the role of circRbms1 and its associated mechanisms in the setting of
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Prognostic effect of systematic geriatric assessment on patients with acute heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-01-29 Lara Aguilar-Iglesias, Ana Merino-Merino, Ester Sanchez-Corral, Maria-Jesus Garcia-Sanchez, Isabel Santos-Sanchez, Jesus Dominguez-Calvo, Ruth Saez-Maleta, Jose-Angel Perez-Rivera
Frailty and dependence are frequent in patients admitted for acute heart failure (AHF), but their prognostic significance is unknown, especially in young adults. We aimed to study in adults admitted for AHF, regardless of age, the effect of frailty and dependence on the incidence of mortality and a combined event of mortality, readmissions for AHF, and visits to the emergency room (ER) for AHF at 1
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Taking a walk on the heart failure side: comparison of metabolic variables during walking and maximal exertion Esc Heart Fail. (IF 3.8) Pub Date : 2024-01-29 Massimo Mapelli, Elisabetta Salvioni, Alice Bonomi, Mara Paneroni, Rosa Raimondo, Paola Gugliandolo, Irene Mattavelli, Jacopo Bidoglio, Kiran K. Mirza, Maria Teresa La Rovere, Finn Gustafsson, Piergiuseppe Agostoni
Although cardiopulmonary exercise testing (CPET) is the gold standard to assess exercise capacity, simpler tests (i.e., 6-min walk test, 6MWT) are also commonly used. The aim of this study was to evaluate the relationship between cardiorespiratory parameters during CPET and 6MWT in a large, multicentre, heterogeneous population.