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CT pericoronary adipose tissue density predicts coronary allograft vasculopathy and adverse clinical outcomes after cardiac transplantation Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-03-17 Christopher Wall, Jonathan Weir-McCall, Katharine Tweed, Stephen P Hoole, Deepa Gopalan, Yuan Huang, Andrej Corovic, Marta Peverelli, Damini Dey, Martin R Bennett, James H F Rudd, Anna Kydd, Sai Bhagra, Jason M Tarkin
Aims To assess pericoronary adipose tissue (PCAT) density on Coronary Computed Tomography Angiography (CCTA) as a marker of inflammatory disease activity in coronary allograft vasculopathy (CAV). Methods and Results PCAT density, lesion volumes, and total vessel volume-to-myocardial mass ratio (V/M) were retrospectively measured in 126 CCTAs from 94 heart transplant patients (mean age 49 [SD 14.5]
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Comparative prognostic importance of measures of left atrial structure and function in non-ischaemic dilated cardiomyopathy Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-03-14 Daniel J Hammersley, Srinjay Mukhopadhyay, Xiuyu Chen, Leanne Cheng, Richard E Jones, Lukas Mach, Lara Curran, Momina Yazdani, Alma Iacob, Amrit S Lota, Zohya Khalique, Antonio De Marvao, Resham Baruah, Kaushik Guha, James S Ware, John Gregson, Shihua Zhao, Dudley J Pennell, Upasana Tayal, Sanjay K Prasad, Brian P Halliday
Aims To compare the association between measures of left atrial (LA) structure and function, derived from cardiovascular magnetic resonance (CMR), with cardiovascular (CV) death or non-fatal heart failure (HF) events in patients with non-ischaemic dilated cardiomyopathy (DCM). Methods and results CMR studies of 580 prospectively recruited patients with DCM in sinus rhythm (median age 54 [interquartile
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Left atrial shape as a marker of atrial myopathy in embolic stroke of undetermined source Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-03-14 Aaisha Ferkh, Kasun De Silva, Jennifer Pham, Luke Stefani, Karen Byth, Amy Clark, Siddharth J Trivedi, Sai Nagaratnam, Andrew Duggins, Eddy Kizana, Aravinda Thiagalingam, Liza Thomas
Aims Embolic Stroke of Undetermined Source (ESUS) results in significant morbidity. A left atrial (LA) myopathy is implicated in a proportion of these patients. We hypothesized that LA shape varies by cause of stroke (cardioembolic versus ESUS). Methods and results 236 ischemic stroke, atrial fibrillation (AF) patients and controls were recruited prospectively. AF was classified as paroxysmal (PAF)
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The Prognostic Impact of Follow-up Cardiac MIBG Imaging on LV trajectory After Acute Decompensation Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-03-14 Kiyomi Kayama, Takahisa Yamada, Masahiro Seo, Tetsuya Watanabe, Takashi Morita, Masato Kawasaki, Atsushi Kikuchi, Tsutomu Kawai, Jun Nakamura, Masatake Fukunami
Aims Cardiac metaiodobenzylguanidine (MIBG) imaging provides prognostic information in patients with heart failure. Recently, the trajectory of left ventricular ejection fraction (LVEF) has been a focus in patients with reduced LVEF admitted for acute decompensated heart failure (ADHF). We sought to investigate the prognostic value of follow-up cardiac MIBG imaging in ADHF patients with reduced LVEF
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Poor in-hospital congestion improvement in acute heart failure patients classified according to LVEF: prognostic implications Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-03-12 Gaetano Ruocco, Nicolas Girerd, Tripti Rastogi, Zohra Lamiral, Alberto Palazzuoli
Background Residual congestion in acute heart failure (AHF) is associated with poor prognosis. However, there is a lack of data on the prognostic value of changes in a combined assessment of in-hospital congestion. The present study sought to assess the association between in-hospital congestion changes and subsequent prognosis according to left ventricular ejection fraction (LVEF) classification.
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Sex differences in left atrial volumes, mechanics and stiffness in primary mitral regurgitation- a combined 2D and 3D echocardiographic study Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-03-12 Christian E Berg-Hansen, Rasmus Bach Sindre, Lisa Grymyr, Barbara Rogge, Andreas Valeur, Stig Urheim, Judy Hung, Dana Cramariuc
Background Mitral regurgitation (MR) causes left atrial (LA) enlargement and impaired reservoir function. We assessed whether changes in LA size, strain and stiffness in significant (moderate or greater) primary MR are sex-specific. Methods and results In the 3D Echocardiography and Cardiovascular Prognosis in Mitral Regurgitation study (3D-PRIME), 111 patients with primary MR were prospectively investigated
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Sex-and age-related variations in myocardial tissue composition of the healthy heart: A native T1 mapping cohort study Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-03-12 Katrine Aagaard Myhr, Liv Andrés-Jensen, Bjørn Strøier Larsen, Joakim Bo Kunkel, Charlotte Burup Kristensen, Niels Vejlstrup, Lars Køber, Redi Pecini
Aims Cardiovascular diseases manifest differently in males and females, potentially influenced by inherent sex- and age-related differences in myocardial tissue composition. Such inherent differences are not well-established in the literature. With this study using cardiac magnetic resonance (CMR) native T1 mapping, we aim to determine the effect of sex and age on myocardial tissue composition in healthy
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Plasma lipidomics and coronary plaque changes: a substudy of the SMARTool clinical trial Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-03-06 Jeff M Smit, Silvia Rocchiccioli, Giovanni Signore, Elena Michelucci, Nicoletta Di Giorgi, Alexander R van Rosendael, Mohammed El Mahdiui, Danilo Neglia, Juhani Knuuti, Antti Saraste, Ronny R Buechel, Anna Teresinska, Maria N Pizzi, Albert Roque, Rosa Poddighe, Bart J Mertens, Chiara Caselli, Oberdan Parodi, Gualtiero Pelosi, Arthur J Scholte
Aims To date, no studies have investigated the association between lipid species and coronary plaque changes over time, quantitatively assessed by serial imaging. We aimed to prospectively determine the association between lipid species quantified by a plasma lipidomic analysis and coronary plaque changes according to composition assessed by a quantitative serial analysis of coronary computed tomography
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Impact of cardiac size on SPECT myocardial perfusion imaging performance: Insights from the REFINE-SPECT registry Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-03-05 Michael J Randazzo, Pierre Elias, Timothy J Poterucha, Tali Sharir, Matthews B Fish, Terrence D Ruddy, Philipp A Kaufmann, Albert J Sinusas, Edward J Miller, Timothy Bateman, Sharmila Dorbala, Marcelo Di Carli, Michelle Castillo, Joanna X Liang, Robert J H Miller, Damini Dey, Daniel S Berman, Piotr J Slomka, Andrew J Einstein
Aims Variation in diagnostic performance of SPECT myocardial perfusion imaging (MPI) has been observed, yet the impact of cardiac size has not been well characterized. We assessed whether low left ventricular volume influences SPECT MPI’s ability to detect obstructive coronary artery disease (CAD), and its interaction with age and sex. Methods and Results A total of 2,066 patients without known CAD
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Association between subclinical atherosclerosis burden and unrecognized myocardial infarction detected by cardiac magnetic resonance in middle-aged adults Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-02-29 Leticia Fernández-Friera, Ana García-Alvarez, Belen Oliva, Inés García-Lunar, Iris García, Andrea Moreno-Arciniegas, Sandra Gómez-Talavera, Cristina Pérez-Herreras, Javier Sánchez-González, Vicente Martínez de Vega, Xavier Rossello, Héctor Bueno, Antonio Fernández-Ortiz, Borja Ibañez, Javier Sanz, Valentín Fuster
Aims Evidence on the association between subclinical atherosclerosis (SA) and cardiovascular (CV) events in low-risk populations is scant. To study the association between SA burden and an ischemic scar (IS), identified by cardiac magnetic resonance (CMR), as a surrogate of CV endpoint, in a low-risk population. Methods A cohort of 712 asymptomatic middle-aged individuals from the Progression of Early
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Mitral Annular Disjunction in Idiopathic Ventricular Fibrillation Patients: Just a Bystander or a Potential Cause? Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-02-27 L M Verheul, M Guglielmo, S A Groeneveld, F P Kirkels, C Scrocco, M J Cramer, M Bootsma, G F L Kapel, M Alings, R Evertz, B A Mulder, N H J Prakken, J C Balt, P G A Volders, A Hirsch, S C Yap, P G Postema, R Nijveldt, B K Velthuis, E R Behr, A A M Wilde, R J Hassink
Aims Previously, we demonstrated that inferolateral mitral annular disjunction (MAD) is more prevalent in patients with idiopathic ventricular fibrillation (IVF) than in healthy controls. In the present study, we advanced the insights into the prevalence and ventricular arrhythmogenicity by inferolateral MAD in an even larger IVF cohort. Methods and results This retrospective multicentre study included
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EACVI survey on the evaluation of mitral regurgitation Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-02-22 Espen Holte, Tomaž Podlesnikar, Fontes Carvalho, Ahmet Demirkiran, Robert Manka, Gabriela Guzmán Martínez, Błażej Michalski J, Agnès Pasquet Separovic, Hatem Soliman-Aboumarie, Joshi Shruti S, Kristina H Haugaa, Marc R Dweck
Aims To evaluate the diagnosis and imaging of patients with mitral regurgitation and the management in routine clinical practice across Europe, the EACVI Scientific Initiatives Committee performed a survey across European centres. In particular, the routine use of echocardiography, advanced imaging modalities, heart valve clinics and heart valve teams was explored. Methods and results A total of 61
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Guiding early revascularization using [15O]H2O positron emission tomography myocardial perfusion imaging: impact of atrial fibrillation Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-02-20 Simon Madsen, Mette Louise Gram Kjaerulff, June Anita Ejlersen, Bent Roni Ranghøj Nielsen, Lars Jakobsen, Jens Sörensen, Lars Poulsen Tolbod, Lars Christian Gormsen
Aims Myocardial perfusion imaging (MPI) using [15O]H2O positron emission tomography (PET) is used to guide the selection of patients with angina for invasive angiography and possible revascularization. Our study evaluated (i) whether atrial fibrillation (AF) reduces global hyperaemic myocardial blood flow (MBF) and (ii) whether [15O]H2O PET MPI effectively guides revascularization procedures for patients
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Automated vessel specific coronary artery calcification quantification with deep learning in a large multi-center registry Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-02-20 Michelle C Williams, Aakash D Shanbhag, Jianhang Zhou, Anna M Michalowska, Mark Lemley, Robert JH Miller, Aditya Killekar, Parker Waechter, Heidi Gransar, Serge D Van Kriekinge, Valerie Builoff, Attila Feher, Edward J Miller, Timothy Bateman, Damini Dey, Daniel Berman, Piotr J Slomka
Aims Vessel specific coronary artery calcification (CAC) is additive to global CAC for prognostic assessment. We assessed accuracy and prognostic implications of vessel-specific automated deep learning (DL) CAC analysis on electrocardiogram gated and attenuation correction computed tomography (CT) in a large multicenter registry. Methods and results Vessel-specific CAC was assessed in the left main/left
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Assessment of Suitability for Percutaneous Mitral Commissurotomy: A Contemporary Review of Key Anatomical Criteria and Predictive Models Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-02-20 Mohammad Abdelghani, Maria Carmo P Nunes, Ashraf M Anwar, Bernard Prendergast
The immediate result of percutaneous balloon mitral commissurotomy (PMC) is largely determined by the anatomy of the mitral valve complex. Several scores and models have been developed to assess anatomical suitability for PMC. Although none has an optimal predictive power, these models look at the valvular apparatus from different perspectives bearing the potential for a complementary role.
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Normal values of myocardial blood flow measured with dynamic myocardial CT perfusion Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-02-19 Mathias B Møller, Jesper J Linde, Andreas Fuchs, Lars V Køber, Børge G Nordestgaard, Klaus F Kofoed
Aims Dynamic myocardial CT perfusion (DM-CTP) can, in combination with coronary CT angiography (CCTA), provide anatomical and functional evaluation of coronary artery disease (CAD). However, normal values of myocardial blood flow (MBF) are needed to identify impaired myocardial blood supply in patients with suspected CAD. We aimed to establish normal values for MBF measured using DM-CTP, to assess
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Peak Atrial Longitudinal Strain and Risk Stratification in Moderate and Severe Aortic Stenosis Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-02-06 Paolo Springhetti, Michele Tomaselli, Giovanni Benfari, Salvatore Milazzo, Luca Ciceri, Marco Penso, Matteo Pilan, Alexandra Clement, Alessandra Rota, Paolo Alberto Del Sole, Stefano Nistri, Denisa Muraru, Flavio Ribichini, Luigi Badano
Aims We sought to investigate the association with outcome of left atrial strain in a large cohort of patients with at least moderate aortic stenosis (AS). Methods and Results we analyzed 467 patients (mean age 80.6 ± 8.2 years; 51% men) with at least moderate AS, and sinus rhythm. The primary study endpoint was the composite of all-cause mortality and hospitalizations for heart failure. After a median
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A Deep Patient-Similarity Learning Framework for the Assessment of Diastolic Dysfunction in Elderly Patients Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-02-02 Rohan Shah, Marton Tokodi, Ankush Jamthikar, Sabha Bhatti, Ehimare Akhabue, Grace Casaclang-Verzosa, Naveena Yanamala, Partho P Sengupta
Background and Aims Age-related changes in cardiac structure and function are well recognized and make the clinical determination of abnormal LV diastolic function (LVDD) particularly challenging in the elderly. We investigated whether a deep neural network (DeepNN) model[70] of LVDD, previously validated in a younger cohort, can be implemented in an older population to predict incident heart failure
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Assessment of paravalvular regurgitation after transcatheter aortic valve replacement using 2D multi-venc and 4D flow CMR Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-02-02 Maxim J P Rooijakkers, Saloua El Messaoudi, Niels A Stens, Marleen H van Wely, Jesse Habets, Monique Brink, Laura Rodwell, Daniel Giese, Rob J van der Geest, Niels van Royen, Robin Nijveldt
Aims To compare the novel 2D multi-venc and 4D flow acquisitions with the standard 2D flow acquisition for the assessment of paravalvular regurgitation (PVR) after TAVR using cardiac magnetic resonance (CMR)-derived regurgitant fraction (RF). Methods and results In this prospective study, patients underwent CMR one month after TAVR to assess PVR using 2D multi-venc and 4D flow, in addition to standard
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Mitral Valve Early Systolic Billowing Induces Following Annular Expansion and Leaflet Augmentation in Barlow’s Disease: Sequential Analysis using Three-dimensional Echocardiography Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-01-30 Masashi Amano, Chisato Izumi, Misako Toki, Yoshiki Yanagi, Akihiro Hayashida, Takahiro Kawamoto, Arudo Hiraoka, Satsuki Fukushima, Taichi Sakaguchi, Nozomi Watanabe, Kiyoshi Yoshida
Aims Although systolic expansion of the annulus has been recognized in Barlow’s disease, the mechanisms of the unique pathological movement of the annulus and its relation to the leaflet augmentation has not yet been clarified. We aimed to investigate the detailed mechanisms of the characteristic mitral apparatus dynamics in Barlow's disease by frame-by-frame sequential geometric analysis using real-time
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Impact of Atherosclerosis Imaging-Quantitative Computed Tomography on Diagnostic Certainty, Downstream Testing, Coronary Revascularization and Medical Therapy: The CERTAIN Study Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-01-25 Nick S Nurmohamed, Jason H Cole, Matthew Budoff, Ronald P Karlsberg, Himanshu Gupta, Lance E Sullenberger, Carlos G Quesada, Habib Rahban, Kevin M Woods, Jeffrey R Uzzilia, Scott L Purga, Melissa Aquino, Udo Hoffmann, James K Min, James P Earls, Andrew D Choi
Aims The incremental impact of Atherosclerosis Imaging-Quantitative Computed Tomography (AI-QCT) on diagnostic certainty and downstream patient management is not yet known. The aim of the present study was to compare the clinical utility of routine implementation of AI-QCT versus conventional visual coronary CT angiography (CCTA) interpretation. Methods and Results In this multicenter crossover study
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Radiographic complicated and uncomplicated descending aortic dissections: aortic morphological differences by CT angiography and risk factor analysis Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-01-25 Tim Berger, Annika Maier, Joseph Kletzer, Christopher L Schlett, Stoyan Kondov, Martin Czerny, Bartosz Rylski, Maximilian Kreibich
Objective To identify radiographic differences between patients with uncomplicated and complicated descending aortic dissections. Methods Between 04/2009 and 07/2021, 209 patients with acute descending aortic dissections were analyzed as complicated (malperfusion, rupture, diameter progress, and diameter ≥55mm) or uncomplicated. Detailed CTA measurements (slice thickness ≤ 3mm) were taken in multiplanar
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Histopathological Myocardial Changes in Patients with Severe Aortic Stenosis Referred for Surgical Valve Replacement: A CMR Correlation Study Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-01-22 João Abecasis, Pedro Lopes, Sergio Maltes, Rita Reis Santos, António Ferreira, Regina Ribeiras, Maria João Andrade, Miguel Sousa Uva, Victor Gil, Ana Félix, Sancia Ramos, Nuno Cardim
Myocardial fibrosis (MF) takes part in left ventricular (LV) remodeling in patients with aortic stenosis (AS), driving the transition from hypertrophy to heart failure. The structural changes that occur in this transition are not fully enlightened. Aim to describe histopathology changes at endomyocardial biopsy (EMB) in patients with severe AS referred to surgical aortic valve replacement (AVR); to
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Clinical and prognostic implications of left ventricular dilatation in heart failure Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-01-22 Gizem Kasa, Albert Teis, Gladys Juncà, Alberto Aimo, Josep Lupón, German Cediel, Evelyn Santiago-Vacas, Pau Codina, Elena Ferrer-Sistach, Nuria Vallejo-Camazón, Jorge López-Ayerbe, Antoni Bayés-Genis, Victoria Delgado
Aims To assess the agreement between left ventricular end-diastolic diameter index (LVEDDi) and volume index (LVEDVi) to define LV dilatation and to investigate the respective prognostic implications in patients with heart failure (HF). Methods and Results Patients with HF symptoms and LV ejection fraction (LVEF) < 50% undergoing cardiac magnetic resonance (CMR) were evaluated retrospectively. LV dilatation
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Normal values for left atrial strain, volume, and function derived from 3D echocardiography: the Copenhagen City Heart Study Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-01-20 Marat Yafasov, Flemming Javier Olsen, Kristoffer Grundtvig Skaarup, Mats Christian Højbjerg Lassen, Niklas Dyrby Johansen, Filip Lyng Lindgren, Gorm Boje Jensen, Peter Schnohr, Rasmus Møgelvang, Peter Søgaard, Tor Biering-Sørensen
Aims 3D echocardiographic (3DE) assessment of the left atrium (LA) is a new modality of potential clinical value. Age- and sex-based normative values are needed to benchmark these parameters for clinical use. Methods and results Of 4466 participants in the 5th Copenhagen City Heart Study, a prospective longitudinal cohort study on the general population, 2082 participants underwent 3DE of the LA. Healthy
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Deep Learning for Automatic Volumetric Segmentation of Left Ventricular Myocardium and Ischemic Scar from Multi-Slice LGE-CMR Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-01-20 Vivek P Jani, Mohammad Ostovaneh, Elzbieta Chamera, Yoko Kato, Joao A C Lima, Bharath Ambale-Venkatesh
Purpose This study details application of deep learning for automatic volumetric segmentation of left ventricular myocardium and scar and automated quantification of myocardial ischemic scar burden from late-gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR). Materials and Methods We included 501 images and manual segmentations of short-axis LGE-CMR from over 20 multinational sites
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Limitations of Apical Sparing Pattern in Cardiac Amyloidosis: A Multicenter Echocardiographic Study Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-01-18 Juan Cotella, Michael Randazzo, Mathew S Maurer, Stephen Helmke, Marielle Scherrer-Crosbie, Marwa Soltani, Akash Goyal, Karolina Zareba, Richard Cheng, James N Kirkpatrick, Vidhushei Yogeswaran, Tetsuji Kitano, Masaaki Takeuchi, Fábio Fernandes, Viviane Tiemi Hotta, Marcelo Luiz Campos Vieira, Pablo Elissamburu, Ricardo Ronderos, Aldo Prado, Efstratios Koutroumpakis, Anita Deswal, Amit Pursnani, Nitasha
Background Although impaired left ventricular (LV) global longitudinal strain (GLS) with apical sparing is a feature of cardiac amyloidosis (CA), its diagnostic accuracy has varied across studies. We aimed to determine the ability of apical sparing ratio (ASR) and most common echocardiographic parameters to differentiate patients with confirmed CA from those with clinical and/or echocardiographic suspicion
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Sex-based Differences in the Phenotypic Expression and Prognosis of Idiopathic Non-ischemic Cardiomyopathy: A Cardiovascular Magnetic Resonance Study Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-01-18 Maggie Mallabone, Dina Labib, Ahmed Abdelhaleem, Steven Dykstra, Richard B Thompson, D Ian Paterson, Sam K Thompson, Fereshteh Hasanzadeh, Yoko Mikami, Sandra Rivest, Jacqueline Flewitt, Yuanchao Feng, Matthew Macdonald, Melanie King, Michael Bristow, Louis Kolman, Andrew G Howarth, Carmen P Lydell, Robert JH Miller, Nowell M Fine, James A White
Aims We sought to characterize sex-related differences in CMR-based cardiovascular phenotypes and prognosis in patients with idiopathic non-ischemic cardiomyopathy (NICM). Methods and results Patients with NICM enrolled in the Cardiovascular Imaging Registry of Calgary (CIROC) between 2015 and 2021 were identified. Z-score values for chamber volumes and function were calculated as standard deviation
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Mixed aortic valve disease: Association with paravalvular leak and reduced survival after TAVR Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-01-18 Caglayan Demirel, Max Paul Winter, Christian Nitsche, Sophia Koschatko, Charlotte Jantsch, Katharina Mascherbauer, Kseniya Halavina, Gregor Heitzinger, Carolina Dona, Varius Dannenberg, Georg Spinka, Matthias Koschutnik, Martin Andreas, Christian Hengstenberg, Philipp E Bartko
Background Transcatheter aortic valve replacement (TAVR) revolutionized the therapy of severe aortic stenosis (AS) with rising numbers. Mixed aortic valve disease (MAVD) treated by TAVR is gaining more interest, as those patients represent a more complex cohort as compared to isolated AS. However, concerning long-term outcome for this cohort only limited data is available. Aims To assess the prevalence
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Transcatheter aortic valve implantation impact on left ventricular myocardial damage: long term follow-up Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-01-18 Frederic Myon, Benjamin Marut, Wojciech Kosmala, Vincent Auffret, Guillaume Leurent, Guillaume L’official, Elizabeth Curtis, Herve Le Breton, Emmanuel Oger, Erwan Donal
Introduction Aortic stenosis (AS) is causing myocardial damages and replacement is mainly indicated based on symptoms. Non-invasive estimation of myocardial work (MW) provide a less afterload dependent tool that, we sought to look at the impact of transcatheter aortic valve implantation (TAVI) on the myocardium at long-term follow-up and according to current indications. Methods We conducted an observational
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Frequency of Screening for Cardiac Allograft Vasculopathy: Warranty Period of Initial Low Risk Positron Emission Tomography Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-01-12 Bryan Abadie, Chonyang Albert, Pavan Bhat, Serge Harb, Miriam Jacob, Randall C Starling, W H Wilson Tang, Wael A Jaber
Aims The short-term risk of moderate-severe cardiac allograft vasculopathy (CAV) after a low-risk positron emission tomography/computed tomography (PET/CT) is unknown and therefore there is no guidance on how frequently to perform screening. The aim of this study was to assess the rate of progression to moderate-severe CAV as part of an annual screening program. Methods and Results Patients with no
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Cardiovascular multimodality imaging in women. A scientific statement of the European Association of Cardiovascular Imaging (EACVI) of the ESC Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-01-09 Ana G Almeida, Julia Grapsa, Alessia Gemelli, Chiara Bucciarelli-Ducci, Bernhard Gerber, Nina Ajmone-Marsan, Anne Bernard, Erwan Donal, Marc R Dweck, Kristina H Haugaa, Krassimira Hristova, Alicia Maceira, Giulia Elena Mandoli, Sharon Mulvagh, Doralisa Morrone, Edyta Plonska-Gosciniak, Leyla Elif Sade, Bharati Schivalkar, Jeanette Schulz-Menger, Leslee Shaw, Marta Sitges, Berlinde von Kemp, Fausto
Cardiovascular diseases (CVD) represent an important cause of mortality and morbidity in women. It is now recognized that there are sex differences regarding the prevalence and the clinical significance of the traditional cardiovascular (CV) risk factors as well as the pathology underlying a range of CVDs. Unfortunately, women have been underrepresented in most CVD imaging studies and trials regarding
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Annular Remodeling predicts Outcome in Isolated Severe Tricuspid Regurgitation: A Registry-based Echocardiographic Analysis Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-01-09 Henrike Arfsten, Andreas König, Welf Geller, Lorenz Bodner, Varius Dannenberg, Suriya Prausmüller, Philipp E Bartko, Thomas Binder, Christian Hengstenberg, Georg Goliasch, Matthias Schneider-Reigbert
Aims Depending on volume status, secondary tricuspid regurgitation (sTR) has a strong dynamic component. In contrast, associated structural dilatation of the tricuspid annulus and the right heart chambers may be less volume dependent. This study aimed to assess the prognostic value of right heart remodeling in isolated severe sTR (isoTR). Methods and Results A total of 36,000 patients from the longitudinal
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Quantification of Right Ventricular Amyloid Burden with 18F-florbetapir PET/CT and its Association with Right Ventricular Dysfunction and Outcomes in Light-Chain Amyloidosis Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-01-09 Yesh Datar, Olivier F Clerc, Sarah A M Cuddy, Sirwoo Kim, Alexandra Taylor, Jocelyn Canseco Neri, Dominik C Benz, Giada Bianchi, Andrew J Yee, Vaishali Sanchorawala, Frederick L Ruberg, Heather Landau, Ronglih Liao, Marie Foley Kijewski, Michael Jerosch-Herold, Raymond Y Kwong, Marcelo F Di Carli, Rodney H Falk, Sharmila Dorbala
Aims In systemic light-chain (AL) amyloidosis, quantification of right ventricular (RV) amyloid burden has been limited and the pathogenesis of RV dysfunction is poorly understood. Using 18F-florbetapir positron emission tomography/computed tomography (PET/CT), we aimed to quantify RV amyloid, correlate RV amyloid with RV structure and function, determine the independent contributions of RV, left ventricular
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Peripheral microvascular function is linked to cardiac involvement on CMR in systemic sclerosis-related pulmonary arterial hypertension Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2024-01-02 Jacqueline L Vos, Jacqueline M J Lemmers, Saloua El Messaoudi, Miranda Snoeren, Arie P J van Dijk, Anthonie L Duijnhouwer, Laura Rodwell, Sander I van Leuven, Martijn C Post, Madelon C Vonk, Robin Nijveldt
Background Systemic sclerosis (SSc) is characterized by vasculopathy, inflammation and fibrosis, and carries one of the worst prognoses if patients also develop pulmonary arterial hypertension (PAH). Although PAH is a known prognosticator, SSc-PAH patients demonstrate disproportionately high mortality, presumably due to cardiac involvement. In this cross-sectional study, the relation between cardiac
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Left Ventricular Myocardial Work Improves in Response to Treatment and is Associated with Survival Among Patients with Light-Chain Cardiac Amyloidosis Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-12-24 Alexandros Briasoulis, Dimitrios Bampatsias, Ioannis Petropoulos, Athanasios Rempakos, Raphael Patras, Foteini Theodorakakou, Nikolaos Makris, Meletios Athanasios Dimopoulos, Kimon Stamatelopoulos, Efstathios Kastritis
Aims Complete hematologic response to treatment for light chain cardiac amyloidosis (AL-CA) may lead to improvement of myocardial function and better outcomes. We sought to evaluate the effect of response to treatment for AL-CA on echocardiographic indices of myocardial deformation and work, and their prognostic significance. Methods and Results Sixty-one patients treated for AL were enrolled and underwent
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Feasibility and Prognostic significance of ventricular-arterial coupling after myocardial infarction: the RIGID-MI cohort Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-12-22 Samy Aghezzaf, Augustin Coisne, Christophe Bauters, Francesco Favata, Pascal Delsart, Amandine Coppin, Claire Seunes, Guillaume Schurtz, Basile Verdier, Nicolas Lamblin, Amine Tazibet, Justine Le Taillandier de Gabory, Sandro Ninni, Erwan Donal, Gilles Lemesle, David Montaigne
Background The clinical significance and feasibility of the recently described non-invasive parameters exploring ventricular-arterial coupling (VAC) remain uncertain. Objectives To assess VAC parameters for prognostic stratification in stable patients with LVEF ≥40% following myocardial infarction (MI). Methods Between 2018 and 2021, patients with LVEF ≥40% were evaluated 1-month following MI using
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Effects of tafamidis on the left ventricular and left atrial strain in patients with wild-type transthyretin cardiac amyloidosis Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-12-18 Rosy Haruna Nishizawa, Hiroaki Kawano, Tsuyoshi Yoshimuta, Chisa Eguchi, Sanae Kojima, Takako Minami, Daisuke Sato, Masamichi Eguchi, Shinji Okano, Satoshi Ikeda, Mitsuharu Ueda, Koji Maemura
Aims Although tafamidis is used in patients with wild-type transthyretin cardiac amyloidosis (ATTRwt-CA), its specific effect on cardiac function is unclear. Thus, this study aimed to investigate the effect of tafamidis on left atrial and ventricular function using speckle-tracking echocardiography for 1 year of treatment in patients with ATTRwt-CA. Methods and results We included 23 patients (mean
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Left Ventricular Fibrosis as a Main Determinant of Filling Pressures and Left Atrial Function in Advanced Heart Failure Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-12-15 Giulia Elena Mandoli, Matteo Cameli, Maria Concetta Pastore, Ferdinando Loiacono, Francesca Maria Righini, Flavio D’Ascenzi, Marta Focardi, Luna Cavigli, Matteo Lisi, Gianluigi Bisleri, Aleksander Dokollari, Sonia Bernazzali, Massimo Maccherini, Serafina Valente, Michael Henein
Background Advanced heart failure (AdHF) is characterized by variable degrees of left ventricular (LV) dysfunction, myocardial fibrosis and raised filling pressures which lead to left atrial (LA) dilatation and cavity dysfunction. This study investigated the relationship between peak atrial longitudinal strain (PALS), assessed by speckle tracking echocardiography (STE), and invasive measures of LV
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Prognostic Value of a Novel Artificial Intelligence-Based Coronary Computed Tomography Angiography-Derived Ischemia Algorithm for Patients with Suspected Coronary Artery Disease Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-12-12 Sarah Bär, Takeru Nabeta, Teemu Maaniitty, Antti Saraste, Jeroen J Bax, James P Earls, James K Min, Juhani Knuuti
Aims Coronary computed tomography angiography (CTA) imaging is used to diagnose patients with suspected coronary artery disease (CAD). A novel artificial-intelligence-guided quantitative computed tomography ischemia algorithm (AI-QCTischemia) aims to identify myocardial ischemia directly from CTA images and may be helpful to improve risk stratification. The aims were 1) the prognostic value of AI-QCTischemia
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Even Mild Mitral Regurgitation is Associated with Incident Atrial Fibrillation in the General Population Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-12-12 Marat Yafasov, Flemming Javier Olsen, Ali Shabib, Kristoffer Grundtvig Skaarup, Mats Christian Højbjerg Lassen, Niklas Dyrby Johansen, Magnus T Jensen, Gorm Boje Jensen, Peter Schnohr, Rasmus Møgelvang, Tor Biering-Sørensen
Background Mitral regurgitation (MR) can be difficult to quantify. We sought to investigate whether the MR jet area to left atrial (LA) area ratio (MR/LA-ratio) method for quantifying MRs can be used to predict incident AF in the general population. Methods The study included 4,466 participants from the 5th Copenhagen City Heart Study, a prospective general population study, who underwent transthoracic
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Prevalence and prognostic impact of dynamic atrial functional mitral regurgitation assessed by isometric handgrip exercise Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-12-08 Maximilian Spieker, Sidabras Jonas, Hannah Lagarden, Lucas Christian, Stephan Angendohr, Elric Zweck, Alex Bejinariu, Verena Veulemanns, Christian Schulze, Amin Polzin, Obaida Rana, Ralf Westenfeld, Malte Kelm, Patrick Horn
Aims In atrial functional mitral regurgitation (aFMR), a considerable proportion of patients displays a discrepancy between symptoms and echocardiographic findings at rest. Exercise testing plays a substantial role in assessing the haemodynamic relevance of mitral regurgitation (MR) and is recommended by current guidelines. Here, we aimed to assess the prevalence, extent, and prognostic impact of exercise-induced
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Regurgitant Volume to LA Volume Ratio in Patients with Secondary MR: The COAPT Trial Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-12-07 Augustin Coisne, Andrea Scotti, Juan F Granada, Paul A Grayburn, Michael J Mack, David J Cohen, Saibal Kar, D Scott Lim, JoAnn Lindenfeld, Jeroen Bax, Lak N Kotinkaduwa, Björn Redfors, Neil J Weissman, Federico M Asch, Gregg W Stone
Aims The conceptual framework of proportionate versus disproportionate mitral regurgitation (MR) translates poorly to individual patients with heart failure (HF) and secondary MR. A novel index, the ratio of MR severity to left atrial volume (LAV), may identify patients with “disproportionate” MR and a higher risk of events. The objectives, therefore, were to investigate the prognostic impact of MR
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Arrhythmic mitral valve prolapse: a practical approach for asymptomatic patients. Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-12-07 Alessandro Malagoli, Alessandro Albini, Giovanni Benfari, Federica Ilardi, Matteo Lisi, Giulia Elena Mandoli, Maria Concetta Pastore, Simona Sperlongano, Matteo Cameli, Antonello D’Andrea
Mitral valve prolapse (MVP) is usually regarded as a benign condition though the proportion of patients with a life-threatening arrhythmic MVP form remains undefined. Recently, an experts’ consensus statement on arrhythmic MVP has proposed approaches for risk stratification across the spectrum of clinical manifestation. However, sudden cardiac death may be the first presentation, making clinicians
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Myocardial work indices in bileaflet mitral valve prolapse patients Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-12-07 Lakshmi Muthukumar, Arshad Jahangir, Muddasir Ashraf, McKenzie Schweitzer, Kelly Pesek, Patrycja Galazka, Matt Umland, Bijoy K Khandheria, A Jamil Tajik
Aims Mechanisms underlying left ventricular dysfunction and arrhythmogenesis in bileaflet mitral valve prolapse (BMVP) patients are not well defined. Myocardial work index (MWI) is a noninvasive assessment that correlates with myocardial oxygen consumption. We aimed to compare global and regional MWI in BMVP patients with normal controls. Methods and results In this retrospective study, we calculated
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Sharp foreign body causing hemopericardium: Bone cement fragment. Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-11-24 Kang-Un Choi,Jong Il Park,Jong-Ho Nam,Chan-Hee Lee,Jang-Won Son
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"Is It The Same Patient?" Evidence of Significant Cardiac Amyloid Regression. Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-11-24 Solomon W Bienstock,Marcos Ferrández-Escarabajal,Michael Hadley,Javier Sanz,Gina LaRocca
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“Artificial Intelligence-Enabled Assessment of Right Ventricular to Pulmonary Artery Coupling in Patients Undergoing Transcatheter Tricuspid Valve Intervention” Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-11-23 Vera Fortmeier, Mark Lachmann, Lukas Stolz, Jennifer von Stein, Matthias Unterhuber, Mohammad Kassar, Muhammed Gerçek, Anne R Schöber, Thomas J Stocker, Hazem Omran, Maria I Körber, Amelie Hesse, Gerhard Harmsen, Kai Peter Friedrichs, Shinsuke Yuasa, Tanja K Rudolph, Michael Joner, Roman Pfister, Stephan Baldus, Karl-Ludwig Laugwitz, Stephan Windecker, Fabien Praz, Philipp Lurz, Jörg Hausleiter, Volker
Background Right ventricular to pulmonary artery (RV-PA) coupling has been established as a prognostic marker in patients with severe tricuspid regurgitation (TR) undergoing transcatheter tricuspid valve interventions (TTVI). RV-PA coupling assesses right ventricular systolic function related to pulmonary artery pressure levels, which are ideally measured by right heart catheterization. This study
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Coronary disorder is not necessarily caused exclusively by coronary microvascular dysfunction in hypertrophic cardiomyopathy. Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-11-22 Estelle Usseglio-Polatera,Laurent Riou,Gilles Barone-Rochette
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Recurrent strokes in a 64-year-old woman caused by left ventricular diverticulum. Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-11-22 Xue-Chen Qiao,Meng-Yun Yan,Zhen-Gang Zhao
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Cardiovascular Magnetic Resonance Imaging Characteristics of a Myocardial Metastatic Melanoma. Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-11-22 Luuk H G A Hopman,Irene M Frenaij,Josephine F Heidendael,Jasper L Selder,Lourens F H J Robbers
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"Three-dimensional transillumination imaging for understanding Unroofed Coronary Sinus Defect". Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-11-21 Javier Cruz-Zarrabal,Jose A Arias-Godinez,Juan F Fritche-Salazar,Edith L Posada-Martinez
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Mammography-Based Deep Learning Model for Coronary Artery Calcification Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-11-21 Sangil Ahn, Yoosoo Chang, Ria Kwon, Jeonggyu Kang, JunHyeok Choi, Ga-Young Lim, Mi-ri Kwon, Seungho Ryu, Jitae Shin
Aims Mammography, commonly used for breast cancer screening in women, can also predict cardiovascular disease. We developed mammography-based deep learning models for predicting coronary artery calcium (CAC) scores, an established predictor of coronary events. Methods and results We evaluated a subset of Korean adults who underwent image mammography and CAC computed tomography and randomly selected
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Evolution and prognostic value of left ventricular deformation and myocardial work parameters in Transthyretin Amyloid Cardiomyopathy Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-11-21 Jerome Antonelli, Antoine Neveu, Wojciech Kosmala, Guillaume L’Official, Elizabeth Curtis, Emmanuel Oger, Erwan Donal
Background Wild-type transthyretin amyloid cardiomyopathy (ATTR-CM) is an increasingly recognized condition. It remains challenging to estimate the extent of disease and the prognosis for most patients. Myocardial work is a sensitive echocardiographic approach that improves the characterization of myocardial damage. Objective We sought to investigate myocardial work parameters in ATTR-CM patients and
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Literature review: Assessing heterogeneity on cardiovascular magnetic resonance imaging– a novel approach to diagnosis and risk stratification in cardiac diseases Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-11-20 Kerrick Hesse, Mohammed Y Khanji, Nay Aung, Ghaith S Dabbagh, Steffen E Petersen, C Anwar A Chahal
Cardiac disease affects the heart non-uniformly. Examples include focal septal or apical hypertrophy with reduced strain in hypertrophic cardiomyopathy (HCM), replacement fibrosis with akinesia in an infarct-related coronary artery territory and pattern of scarring in dilated cardiomyopathy. The detail and versatility of cardiovascular magnetic resonance imaging (CMR) mean it contains a wealth of information
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Temporal Patterns of Left Ventricular Systolic and Diastolic Metrics Changes in Adult Patients with Hematological Malignancies Treated With Chimeric Antigen Receptor (CAR)-T Cells: Results from the CARdio-Tox Prospective Study. Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-11-19 Massimiliano Camilli,Antonella Lombardo,Filippo Crea,Giorgio Minotti
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Assessment of myocardial injuries in ischemic and non-ischemic cardiomyopathies using magnetic resonance T1-rho mapping Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-11-18 Aurélien Bustin, Xavier Pineau, Soumaya Sridi, Ruud B van Heeswijk, Pierre Jaïs, Matthias Stuber, Hubert Cochet
Aims To identify clinical correlates of myocardial T1ρ and to examine how myocardial T1ρ values change under various clinical scenarios. Methods and results A total of 66 patients (26% female, median age 57 years [Q1-Q3, 44-65 years]) with known structural heart disease and 44 controls (50% female, median age 47 years [28-57 years]) underwent cardiac magnetic resonance imaging at 1.5-T, including T1ρ
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Left Ventricular Mechanical Dispersion as a Predictor of need for Pacemaker implantation after TAVI Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-11-17 E Kaya, K Andresen, Ø H Lie, L Aaberge, K Haugaa, T Edvardsen, H Skulstad
Aims Permanent pacemaker (PM) implantation is common after TAVI. Left ventricular mechanical dispersion (MeDi) by speckle tracking echocardiography is a marker of fibrosis that causes alterations in the conduction system. We hypothesized that MeDi can be a predictor of need for PM implantation after TAVI. Methods and Results Consecutively, 200 TAVI patients were enrolled. Transthoracic echocardiography
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Exercise Pulmonary Hypertension by the mPAP/CO slope in Primary Mitral Regurgitation Eur. Heart J. Cardiovasc. Imaging (IF 6.2) Pub Date : 2023-11-16 Sebastiaan Dhont, Jan Stassen, Lieven Herbots, Sarah Hoedemakers, Youri Bekhuis, Ruta Jasaityte, Sarah Stroobants, Thibault Petit, Elise Bakelants, Maarten Falter, Sara Moura Ferreira, Guido Claessen, Petra Nijst, Pieter M Vandervoort, Philippe B Bertrand, Jan Verwerft
Aims Exercise-induced pulmonary hypertension (PH), defined by a mean pulmonary arterial pressure over cardiac output (mPAP/CO) slope >3 mmHg/L/min has important diagnostic and prognostic implications. The aim of this study is to investigate the value of the mPAP/CO slope in patients with more than moderate primary MR with preserved ejection fraction and no or discordant symptoms. Methods and Results