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Real-World Outcomes of FLOT versus CROSS Regimens for Patients with Oesophagogastric Cancers. Gastrointest. Tumors Pub Date : 2023-08-03 Adel Shahnam,Udit Nindra,Nicholas McNamee,Robert Yoon,Ray Asghari,Weng Ng,Deme Karikios,Mark Wong
Introduction Treatment of oesophageal (OC), gastro-oesophageal junction (GOJ), and gastric cancer (GC) includes either neoadjuvant Chemoradiotherapy for Oesophageal Cancer Followed by Surgery Study (CROSS) for OC or GOJ or perioperative 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) for OC, GOJ, and GC adenocarcinomas. This study aims to describe the real-world outcomes of patients with
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Association between serum zinc levels and clinicopathological characteristics in patients with gastric cancer Gastrointest. Tumors Pub Date : 2023-02-27
Introduction: Although it was reported that serum zinc levels were lower in patients with various malignancies, serum zinc levels of patients with gastric cancer was not well documented. Objectives: This study aimed to evaluate the association between clinicopathologic features and serum zinc levels in preoperative patients with gastric cancer. Methods: The study enrolled 83 patients scheduled for
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Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer. Gastrointest. Tumors Pub Date : 2023-02-27 Tsutomu Namikawa,Masato Utsunomiya,Keiichiro Yokota,Masaya Munekage,Sunao Uemura,Hiromichi Maeda,Hiroyuki Kitagawa,Michiya Kobayashi,Kazuhiro Hanazaki
Introduction Although it was reported that serum zinc levels were lower in patients with various malignancies, serum zinc levels of patients with gastric cancer were not well documented. Objectives This study aimed to evaluate the association between clinicopathologic features and serum zinc levels in preoperative patients with gastric cancer. Methods The study enrolled 83 patients scheduled for gastric
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Association between serum zinc levels and clinicopathological characteristics in patients with gastric cancer Gastrointest. Tumors Pub Date : 2023-02-27
Introduction: Although it was reported that serum zinc levels were lower in patients with various malignancies, serum zinc levels of patients with gastric cancer was not well documented. Objectives: This study aimed to evaluate the association between clinicopathologic features and serum zinc levels in preoperative patients with gastric cancer. Methods: The study enrolled 83 patients scheduled for
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Mixed Neuroendocrine and Non-Neuroendocrine Neoplasm of Pancreas: What Do We Know, What Have We Learnt? Gastrointest. Tumors Pub Date : 2023-02-08
Pancreatic adeno- Mixed neuroendocrine non-endocrine (pMINEN) are extremely rare. [1] They are known to have distal metastasis at presentation and also have a comparatively lower survival rate as compared to similar staged neuroendocrine carcinoma, adenocarcinoma, and small cell lung tumor from which its treatment patterns are extrapolated. [2,3] Also, very less is known about its molecular structure
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Mixed Neuroendocrine and Non-Neuroendocrine Neoplasm of Pancreas: What Do We Know, What Have We Learnt? Gastrointest. Tumors Pub Date : 2023-02-08 Vijay W. Dhakre, Sneha Tukaram Galande, Varsha Gunvant Patil, Nikita C Shah, Chetan Rathod, Kaiumarz S. Sethna, Anjali D Amrapurkar
Pancreatic adeno- Mixed neuroendocrine non-endocrine (pMINEN) are extremely rare. [1] They are known to have distal metastasis at presentation and also have a comparatively lower survival rate as compared to similar staged neuroendocrine carcinoma, adenocarcinoma, and small cell lung tumor from which its treatment patterns are extrapolated. [2,3] Also, very less is known about its molecular structure
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Mast Cell Sarcoma of Small Intestine, Early Diagnosis and Good Prognosis: An extremely Rare Case Report and Review of the Literature Gastrointest. Tumors Pub Date : 2023-01-05 Bita Geramizadeh, Sara Nabavizadeh, Alireza Rezvani, Nadereh Shamsolvaezin, Alireza Zahedinassab, Neda Khodadadi, Pouya Iranpour
Background: Gastrointestinal mast cell sarcoma is a rare variant of mastocytosis. It is a unifocal tumor with high destructive capacity and metastatic potential. Diagnosis of mast cell sarcoma can be challenging and might be so delayed that unfavorable prognosis may be expected. In this case report, we will describe our experience with a case of mast cell sarcoma in the small intestine of an elderly
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Mast Cell Sarcoma of Small Intestine, Early Diagnosis, and Good Prognosis: An Extremely Rare Case Report and Review of the Literature Gastrointest. Tumors Pub Date : 2023-01-05
Gastrointestinal mast cell sarcoma is a rare variant of mastocytosis. It is a unifocal tumor with high destructive capacity and metastatic potential. Diagnosis of mast cell sarcoma can be challenging and might be so delayed that unfavorable prognosis may be expected. In this case report, we will describe our experience with a case of mast cell sarcoma in the small intestine of an elderly woman, which
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Usefulness of the Japan Esophageal Society classification of Barrett’s esophagus for diagnosing the lateral extent of superficial short-segment Barrett’s esophageal cancer Gastrointest. Tumors Pub Date : 2022-06-20 Yugo Suzuki, Takayuki Okamura, Akira Matsui, Junnosuke Hayasaka, Kosuke Nomura, Daisuke Kikuchi, Shu Hoteya
Introduction: The Japanese guidelines for endoscopic submucosal dissection (ESD) of Barrett’s esophageal adenocarcinoma (BEA) recommend image-enhanced magnifying endoscopic examination for diagnosing the lateral extent of superficial esophageal adenocarcinoma. The Japan Esophageal Society Barrett’s Esophagus (JES-BE) classification is proposed recently and useful in terms of diagnostic accuracy. In
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Usefulness of the Japan Esophageal Society Classification of Barrett’s Esophagus for Diagnosing the Lateral Extent of Superficial Short-Segment Barrett’s Esophageal Cancer Gastrointest. Tumors Pub Date : 2022-06-20
Introduction: The Japanese guidelines for endoscopic submucosal dissection (ESD) of Barrett’s esophageal adenocarcinoma (BEA) recommend image-enhanced magnifying endoscopic examination for diagnosing the lateral extent of superficial esophageal adenocarcinoma. The Japan Esophageal Society Barrett’s Esophagus (JES-BE) classification is proposed recently and is useful in terms of diagnostic accuracy
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Analyzing TCGA Data to Identify Gene Mutations Linked To Hepatocellular Carcinoma in Asians Gastrointest. Tumors Pub Date : 2022-04-20 Tane Kim, Danny Issa, Mykola Onyshchenko
Introduction Liver cancer is the sixth most common and second most fatal type of cancer worldwide. Few treatment options are available, as patients with liver cancer are often diagnosed in an advanced stage due to a lack of clinical symptoms. Effectively preventing and treating liver cancer relies heavily on early diagnosis; early diagnosis results from identifying and monitoring high-risk patients
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Analyzing TCGA Data to Identify Gene Mutations Linked to Hepatocellular Carcinoma in Asians Gastrointest. Tumors Pub Date : 2022-04-20
Introduction: Liver cancer is the sixth most common and second most fatal type of cancer worldwide. Few treatment options are available as patients with liver cancer are often diagnosed in an advanced stage due to a lack of clinical symptoms. Effectively preventing and treating liver cancer relies heavily on early diagnosis; early diagnosis results from identifying and monitoring high-risk patients
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Sequential treatment strategy using fluoropyrimidine plus bevacizumab followed by oxaliplatin for metastatic colorectal cancer: A phase II study (OGSG 1107) Gastrointest. Tumors Pub Date : 2022-02-15 Toshifumi Yamaguchi, Motoki Yoshida, Hisato Kawakami, Takayuki Kii, Hiroko Hasegawa, Takahiro Miyamoto, Tetsuji Terazawa, Fukutaro Shimamoto, Masayoshi Yasui, Daisuke Sakai, Toshio Shimokawa, Yukinori Kurokawa, Masahiro Goto, Taroh Satoh
Introduction: Previous prospective studies suggest that the sequential use of cytotoxic agents, such as oxaliplatin, in patients with metastatic colorectal cancer (mCRC) has the potential to improve prognosis and maintain quality of life than combination chemotherapy. The purpose of this study was to investigate the feasibility and effectiveness of a sequential treatment strategy consisting of an initial
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Sequential Treatment Strategy Using Fluoropyrimidine plus Bevacizumab Followed by Oxaliplatin for Metastatic Colorectal Cancer: A Phase II Study (OGSG 1107) Gastrointest. Tumors Pub Date : 2022-02-15
Introduction: Previous prospective studies suggest that the sequential use of cytotoxic agents, such as oxaliplatin, in patients with metastatic colorectal cancer (mCRC) has the potential to improve prognosis and maintain quality of life than combination chemotherapy. The purpose of this study was to investigate the feasibility and effectiveness of a sequential treatment strategy consisting of an initial
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Successful use of direct Splenic Vein anastomosis to the interposition Internal Jugular Vein graft after extended pancreatoduodenectomy to avoid sinistral portal hypertension. Gastrointest. Tumors Pub Date : 2022-02-14 Vijay W. Dhakre, Shrikant S. Suryawanshi, Vijay P. Shewale, Chetan Rathod, Sneha Tukaram Galande, Kaiumarz S. Sethna
Splenic vein ligation may be needed during Porto-mesenteric junction resection, in pancreatoduodenectomy. Sinistral portal hypertension is a concern if the splenic vein is not drained. Various techniques are described to reconstruct the splenic vein to avoid the variceal formation and sinistral portal hypertension which may lead to GI bleeding. We describe a case of a 19-year female who underwent
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Successful Use of Direct Splenic Vein Anastomosis to the Interposition Internal Jugular Vein Graft after Extended Pancreatoduodenectomy to Avoid Sinistral Portal Hypertension Gastrointest. Tumors Pub Date : 2022-02-14
Splenic vein (SV) ligation may be needed during portomesenteric junction resection, in pancreatoduodenectomy. Sinistral portal hypertension is a concern if the SV is not drained. Various techniques are described to reconstruct SV to avoid the variceal formation and sinistral portal hypertension which may lead to GI bleed. We describe a case of a 19-year-old female who underwent pancreatoduodenectomy
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Endobiliary Radiofrequency Ablation (ELRA) for Malignant Biliary Obstruction over 32 months follow-up Gastrointest. Tumors Pub Date : 2022-02-02 Davide Lanza, Adrian Casty, Stefan H. Schlosser
Hilar cholangiocellular carcinoma (CCC) is a malignant neoplasm of epithelial origin occurring at the confluence of the right and left hepatic bile ducts. Typically, these tumors are small, poorly differentiated, exhibit aggressive biologic behavior with non-specific symptoms and tend to obstruct the intrahepatic bile ducts. Surgery is the only available curative option. Unfortunately, in less than
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Endobiliary Radiofrequency Ablation for Malignant Biliary Obstruction over 32-Month Follow-Up Gastrointest. Tumors Pub Date : 2022-02-02
Hilar cholangiocellular carcinoma (CCC) is a malignant neoplasm of epithelial origin occurring at the confluence of the right and left hepatic bile ducts. Typically, these tumors are small, poorly differentiated, exhibit aggressive biologic behavior with non-specific symptoms and tend to obstruct the intrahepatic bile ducts. Surgery is the only available curative option. Unfortunately, in less than
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Trends of Clinical Outcomes of Patients with Advanced Hepatocellular Carcinoma Treated with First-line Sorafenib in Randomized Controlled Trials Gastrointest. Tumors Pub Date : 2021-12-22 Timothy J. Brown, Arjun Gupta, Ramy Sedhom, Muhammad S. Beg, Thomas B. Karasic, Mark Yarchoan
Background: Sorafenib has consistently served as the control arm in multiple RCTs evaluating novel therapies for advanced HCC for more than a decade. Analyzing trends in clinical outcomes of patients treated with sorafenib for the same indication over time offers the opportunity for unique insight into the evolution of clinical trial conduct and potential non-drug factors impacting outcomes. Methods:
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Trends of Clinical Outcomes of Patients with Advanced Hepatocellular Carcinoma Treated with First-Line Sorafenib in Randomized Controlled Trials Gastrointest. Tumors Pub Date : 2021-12-22
Background: Sorafenib has consistently served as the control arm in multiple randomized clinical trials (RCTs) evaluating novel therapies for advanced hepatocellular carcinoma (HCC) for more than a decade. Analyzing trends in clinical outcomes of patients treated with sorafenib for the same indication over time offers the opportunity for unique insight into the evolution of clinical trial conduct and
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Lower Extremity Varicose Veins: An Unusual Presentation of Small Bowel Leiomyosarcoma Gastrointest. Tumors Pub Date : 2021-11-18 Karim Abou El Joud, Misha Abbasi
Leiomyosarcomas are extremely rare and comprise only 1.2% of small bowel malignancies. Advancements in immunohistochemical techniques have allowed for the differentiation between leiomyosarcomas and gastrointestinal stromal tumors (GISTs). Leiomyosarcomas remain difficult to detect via endoscopy and require a more intricate diagnostic approach. The staging and sizing of these tumors are important prognostic
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Gallbladder Neuroendocrine Tumors (NETs): Is there a need for a specific approach? Gastrointest. Tumors Pub Date : 2021-11-18 Vijay Waman Dhakre, Govind Purushothaman, Nilesh Doctor
Neuroendocrine tumors (NETS) of the Gallbladder or the biliary tree are rare. Most of the current guidelines and protocols are derived from the experience of managing Lung small cell neuroendocrine carcinoma (SCNEC) or gastrointestinal (GI) NETS. But the overall outcome of Gallbladder NETS (GB NETS) seems worse than similarly staged lung NETS and adenocarcinoma of the gallbladder. This may be due to
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Lower Extremity Varicose Veins: An Unusual Presentation of Small Bowel Leiomyosarcoma Gastrointest. Tumors Pub Date : 2021-11-18
Leiomyosarcomas (LMSs) are extremely rare and comprise only 1.2% of small bowel malignancies. Advancements in immunohistochemical techniques have allowed for the differentiation between LMSs and gastrointestinal stromal tumors. LMSs remain difficult to detect via endoscopy and require a more intricate diagnostic approach. The staging and sizing of these tumors are important prognostic indicators. We
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Gallbladder Neuroendocrine Tumors: Is There a Need for a Specific Approach? Gastrointest. Tumors Pub Date : 2021-11-18
Neuroendocrine tumors (NETs) of the gallbladder or the biliary tree are rare. Most of the current guidelines and protocols are derived from the experience of managing lung small cell neuroendocrine carcinoma or gastrointestinal NETs. But, the overall outcome of gallbladder NETs (GB-NETs) seems worse than similarly staged lung NETs and adenocarcinoma of the gallbladder. This may be due to its rarity
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Thyroid disease and hepatocellular carcinoma survival. A Danish nationwide cohort study Gastrointest. Tumors Pub Date : 2021-11-04 Linda Skibsted Kornerup, Frederik Kraglund, Ulla Feldt-Rasmussen, Peter Jepsen, Hendrik Vilstrup
Introduction Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer mortality worldwide. Recent animal studies suggest that thyroid hormone treatment improves HCC prognosis. The aim of this study was to describe the association between thyroid disease and HCC prognosis in humans. Methods We performed a nationwide cohort study including all persons with an HCC diagnosis from 2000-2018
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Acknowledgement to Reviewers Gastrointest. Tumors Pub Date : 2021-10-05
Gastrointest Tumors 2021;8:193
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Abdominal Viscera Migration Performing Hemodynamic Instability after Esophagectomy: A Case Report Gastrointest. Tumors Pub Date : 2021-09-08 Ian Torres de Lima, Edno Tales Bianchi, Gabriel Lunardi Aranha, Beatriz Camargo Azevedo, Guilherme Naccache Namur, Jaime Arthur Pirola Kruger
Hiatal hernia is a rare postoperative complication of esophagectomy in the treatment of esophageal cancer. Although rare, its incidence increased after the establishment of minimally invasive surgical techniques. The patient is usually oligosymptomatic, and the diagnosis is made in the late postoperative period, during outpatient follow-up. The initial presentation of hiatus hernia with hemodynamic
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Prognostic and Clinicopathologic Significance of Discoidin Domain Receptors in Different Human Malignancies: A Meta-Analysis Gastrointest. Tumors Pub Date : 2021-08-05 Gordon A. Ferns, Sheida Shabanian, Milad Shahini Shams Abadi, Ahmadshah Farhat, Mohammad-Hassan Arjmand
Background: Discoidin domain receptors (DDRs) belong to the receptor tyrosine kinases family and are activated by different types of collagens, which play roles in various physiological processes. An abnormal expression of DDRs is reported in different types of cancers. Despite many reports about the association and roles of high DDR expression levels in cancers, the prognostic values of DDRs are still
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The Potential Role of Changes in the Glucose and Lipid Metabolic Pathways in Gastrointestinal Cancer Progression: Strategy in Cancer Therapy Gastrointest. Tumors Pub Date : 2021-08-05 Gordon A. Ferns, Milad Shahini Shams Abadi, Ahmad Raeisi, Mohammad-Hassan Arjmand
Background: Changes in cell metabolism are a well-known feature of some cancers, and this may be involved in the etiology of tumor formation and progression, as well as tumor heterogeneity. These changes may affect fatty acid metabolism and glycolysis and are required to provide the increase in energy necessary for the high rate of proliferation of cancer cells. Gastrointestinal cancers remain a difficult-to-treat
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Cholangiocarcinoma: An Emerging Target for Molecular Therapy Gastrointest. Tumors Pub Date : 2021-07-21 Ilya Tsimafeyeu, Mark Temper
Background: Cholangiocarcinoma has been traditionally considered a tumor with poor prognosis. Until now, surgical treatment has been the only more or less effective approach. Summary: Over 10 years, chemotherapy with a combination of gemcitabine and cisplatin remains the standard first-line therapy for patients with locally advanced or metastatic cholangiocarcinoma, which leads to a median overall
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CircRNAs: Insights into Gastric Cancer Gastrointest. Tumors Pub Date : 2021-07-16 Sanjana Rajgopal, Sherine Joanna Fredrick, Venkatachalam Deepa Parvathi
Background: Gastric cancer (GC) is recorded as the fifth most common cancer globally. The classic resemblance of early symptoms of chronic gastritis including nausea, dysphagia, and dyspepsia with GC is the current challenge limiting the early diagnosis of GC. The current diagnostic procedures of GC are limited due to their invasive nature. This directs the research question toward alternative approaches
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Hepatic Arterial Infusion Chemotherapy Is a Feasible Treatment Option for Hepatocellular Carcinoma: A New Update Gastrointest. Tumors Pub Date : 2021-07-15 Maher Hendi, Yiping Mou, Jiemin Lv, Bin Zhang, Xiujun Cai
Background: Hepatic arterial infusion chemotherapy (HAIC) is one option for treating massive tumors and unresectable hepatocellular carcinoma (HCC). However, there is a lack of remedial treatment after these treatments are ineffective or failed. Summary: Some studies have discovered that HAIC has greater survival in patients with advanced HCC. A previous study has shown that HAIC is effective in the
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Perforated High-Grade Mixed Neuroendocrine Nonneuroendocrine Neoplasm of Cecum: Unusual Presentation of Rare Disease Gastrointest. Tumors Pub Date : 2021-04-20 Gunasekaran Gopalakrishnan, Bheemanathi Hanuman Srinivas, Biju Pottakkat, Senthil Gnanasekaran, Raja Kalayarasan
Mixed neuroendocrine nonneuroendocrine neoplasms (MiNENs) are rare neoplasms of the gastrointestinal tract, where the neuroendocrine as well as the nonneuroendocrine components each comprise at least 30% of the tumor. Of all cases of colorectal malignancies, MiNENs constitute around 3–9.6%, with only a few cases reported to be arising in the cecum. Since majority present with nonspecific clinical and
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Etiological Analysis of Reactive Gastropathy in an Urban Population Gastrointest. Tumors Pub Date : 2021-04-14
Background: Reactive gastropathy (RG) is an adaptive response to assaults of the gastric mucosa. Demographic information regarding RG as well as the coincidence of RG and gastrointestinal cancer are poorly characterized entities. Objective: Herein, we aim to investigate relationships of RG to both modifiable and nonmodifiable risk factors, as well as conduct a stratified analysis by race in an ethnically
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Etiological Analysis of Reactive Gastropathy in an Urban Population. Gastrointest. Tumors Pub Date : 2021-04-14 Sindhura Kolli,Amit Mori,Simcha Weissman,Tej I Mehta,Khoi Paul Dang-Ho,Jamil Shah,Manpreet Singh,Madhavi Reddy,Anand Suryanarayan
BACKGROUND Reactive gastropathy (RG) is an adaptive response to assaults of the gastric mucosa. Demographic information regarding RG as well as the coincidence of RG and gastrointestinal cancer are poorly characterized entities. OBJECTIVE Herein, we aim to investigate relationships of RG to both modifiable and nonmodifiable risk factors, as well as conduct a stratified analysis by race in an ethnically
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Inferior Vena Cava Syndrome as a Manifestation of Metastatic Carcinoid Tumor Gastrointest. Tumors Pub Date : 2021-04-13 Matthew Stankard, Erik Soule, Jerry Matteo
Small bowel-origin carcinoid tumor is indolent but may metastasize relentlessly to various sites, including the liver. Over the past 9 years, we have treated a 69-year-old woman who has undergone 5 percutaneous liver ablations, 5 hepatic intra-arterial chemoembolizations, an ovarian cryoablation, and a trans-ventral hernia mesenteric cryoablation. These interventions are all related to her inoperable
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The Potential Association between the Risk of Post-Surgical Adhesion and the Activated Local Angiotensin II Type 1 Receptors: Need for Novel Treatment Strategies Gastrointest. Tumors Pub Date : 2021-03-31 Mahmood Tavakkoli, Saeed Aali, Borzoo Khaledifar, Gordon A. Ferns, Majid Khazaei, Kiavash Fekri, Mohammad-Hassan Arjmand
Background: Post-surgical adhesion bands (PSABs) are a common complication after abdominal or pelvic surgeries for different reasons like cancer treatment. Despite improvements in surgical techniques and the administration of drugs or the use of physical barriers, there has only been limited improvement in the frequency of postoperative adhesions. Complications of PSAB are pain, infertility, intestinal
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Gastrointestinal Stromal Tumor of the Ampulla of Vater: A Narrative Review Gastrointest. Tumors Pub Date : 2021-03-31 Bita Geramizadeh, Alireza Shojazadeh
Background: Gastrointestinal stromal tumor (GIST) of the ampulla of Vater is a rare occurrence. To the best of our knowledge, there has been no published review on this rare tumor in the English literature so far. Summary: In this review, we will discuss all the reported details of the published cases, including demography, clinical presentation, imaging, gross pathology and histopathology, immunohistochemical
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Does Radiation Dose to Gastric Fundus during Neoadjuvant Chemoradiotherapy for Esophageal Carcinoma Have an Impact on Postoperative Anastomotic Leak? Gastrointest. Tumors Pub Date : 2021-03-17 Nikhila Radhakrishna, Shyama Prem Sudha, Raja Kalayarasan, Prasanth Penumadu
Background: Radiation dose received by the gastric fundus (GF) in neoadjuvant chemoradiotherapy (NACRT) may influence the development of postoperative anastomotic leak (AL) in the management of resectable esophageal carcinoma (EC) by trimodality therapy. The present study aims to evaluate dose-volume parameters of the GF and their association with occurrence of AL in EC. Materials and Methods: A retrospective
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Perioperative Predictive Markers for Recurrence of Esophageal Cancer after Esophagectomy Gastrointest. Tumors Pub Date : 2021-03-17 Yoshinori Fujiwara, Masaharu Higashida, Hisako Kubota, Yuko Okamoto, Shumei Mineta, Shunji Endo, Tomio Ueno
Introduction: We studied whether perioperative nutritional, immunological factors or postoperative inflammatory responses predicted esophageal cancer (EC) progression and prognosis in patients who received esophagectomies. Methods: We evaluated preoperative prognostic nutritional index (PNI), BMI, neutrophil-to-lymphocyte ratio (NLR), intraoperative blood loss, postoperative C-reactive protein (CRP)
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Hepatocellular Malignant Neoplasm, Not Otherwise Specified: A New Name in Liver Tumors: A Brief Narrative Review of Published Cases Gastrointest. Tumors Pub Date : 2021-03-11 Bita Geramizadeh, Razieh Foroughi, Alireza Shojazadeh
Background: Hepatocellular malignant neoplasm, not otherwise specified (HEM, NOS), is a rare liver tumor that is most commonly seen in adolescents. To the best of our knowledge, there has been no published review on this rare tumor in the English literature so far. Summary: In this review, we will discuss all reported details, including demographic findings, clinical presentations, molecular histogenesis
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Capecitabine as Maintenance Therapy for High-Risk, Resected Colorectal Cancer Gastrointest. Tumors Pub Date : 2021-03-10 Miklos L. Auber, Sijin Wen, Gerald Hobbs, Gerald M. Higa
Introduction: In 2020, colorectal cancer will be the fourth most frequently diagnosed malignant neoplasm and the second leading cause of site-specific, cancer-related deaths in the USA. Notably, 80% of the new cases are, by staging criteria, potentially curable even those with completely resected stage 4 disease. If slightly more than half the losses can be attributed to metastatic disease at presentation
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Anal Cancer with Mediastinal Lymph Node Metastasis Gastrointest. Tumors Pub Date : 2021-03-08 Mangalore Amith Shenoy, Lydia Winnicka, Leili Mirsadraei, Douglas Marks
Squamous cell carcinoma of the anal canal remains rare, with metastatic disease even less commonly reported. We present a case of a patient with both a prior history of squamous cell carcinoma of the anal canal as well as breast cancer, who was without evidence of disease for 1 year. She was subsequently found to have FDG-avid mediastinal lymphadenopathy, initially assumed to be related to her more
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Screening Status as a Determinant of Choice of Colorectal Cancer Screening Method: A Population-Based Informed Survey Gastrointest. Tumors Pub Date : 2021-03-05
Objectives: Fecal blood testing is a noninvasive alternative to colonoscopy for colorectal cancer (CRC) screening and is preferred by a substantial proportion of individuals. However, participant-related determinants of the choice of screening method, particularly up-to-date screening status, remain less studied. We aimed to determine if up-to-date screening status was related to choosing a fecal blood
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Metastatic Hepatic Epitheloid Hemangioendothelioma in a Young Male: A Rare Presentation Gastrointest. Tumors Pub Date : 2021-02-18 Tanweerul Huda, Mohammad Masoom Parwez, Bharati Pandya
Hepatic EHE (epithelioid hemangioendothelioma) is an uncommon entity of vascular origin and a low-grade malignant tumor. Primary hepatic EHE is rare. These tumors can be multifocal at presentation like in the soft tissues, bones, brain, liver, and small intestine. First described by Weiss and Enzinger in 1982 as a malignant vascular neoplasm with indolent behavior. We report the case of a 23-year-old
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Common Presentation of an Uncommon Small Intestinal Lymphoma: A Rare Case Entity Gastrointest. Tumors Pub Date : 2021-02-17 Sushma Bharti, Jyotsna Naresh Bharti, Mahendra Lodha
Primary gastrointestinal NHL accounts for 30–40% of all extranodal NHL. Primary gastrointestinal lymphomas constitute 5% of total gut neoplasms. Bowel perforation is a severe life-threatening complication and sometimes initial presentation of gastrointestinal lymphoma. A 60-year-old man presented with complaints of abdominal pain, distension, nausea and vomiting. There was clinical suspicion of acute
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Trends and In-Hospital Outcomes of Splanchnic Vein Thrombosis Associated with Gastrointestinal Malignancies: A Nationwide Analysis Gastrointest. Tumors Pub Date : 2021-02-09 Shivani Handa, Kamesh Gupta, Michelle Sterpi, Ahmad Khan, Abhinav Hoskote, Anup Kasi
Introduction: Gastrointestinal cancers have a strong association with splanchnic vein thrombosis (SVT), yet the hospitalization data is unknown. Objective and Methods: We analyzed around 78 million discharges from the 2007–2017 Nationwide Inpatient Sample with an inclusion criterion of adult patients admitted for portal or hepatic vein thrombosis as a primary diagnosis with a gastrointestinal or hepatobiliary
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Common and Rare Histological Variants of Hepatoblastoma in Children: A Pathological Diagnosis and Review of the Literature Gastrointest. Tumors Pub Date : 2021-02-04 Sushma Bharti, Jyotsna Naresh Bharti, Arvind Sinha, Taruna Yadav
Hepatoblastoma (HB) is a rare tumor, but it is the most common primary liver malignancy in children and comprised of approximately 1% of all pediatric malignancies. Mostly, this tumor is sporadic in nature but can show a syndrome association. Upregulation in Wnt/β-catenin pathway can be there in 70–80% cases of HB. Most often present as abdominal mass and has a raised alpha-fetoprotein levels. Distant
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Clear-Cell Adenocarcinoma of the Gallbladder with Alpha-Fetoprotein Production: A Case Report and Review of the Literature Gastrointest. Tumors Pub Date : 2021-01-27 Nutan Dixit, Shalini Trivedi, Vikas Kumar Bansal
Gallbladder tumors are the fifth most common cancers of the gastrointestinal tract with poor prognosis and low survival. The most common type is adenocarcinoma of which the clear cell type is an unusual histologic variant with alpha-fetoprotein (AFP)-producing gallbladder carcinoma, reported extremely rarely, which makes the index case an uncommon entity. AFP secretion by gallbladder carcinomas may
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Screening Status as a Determinant of Choice of Colorectal Cancer Screening Method: A Population-Based Informed Survey Gastrointest. Tumors Pub Date : 2021-01-01 José Luis Sandoval,Allan Relecom,Cyril Ducros,Jean-Luc Bulliard,Beatrice Arzel,Idris Guessous
Objectives: Fecal blood testing is a noninvasive alternative to colonoscopy for colorectal cancer (CRC) screening and is preferred by a substantial proportion of individuals. However, participant-related determinants of the choice of screening method, particularly up-to-date screening status, remain less studied. We aimed to determine if up-to-date screening status was related to choosing a fecal blood
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The Effect of Laparoscopic Technique on the Surgical Outcome of Colorectal Cancer in a Small-Volume Rural Finnish Lapland Central Hospital Gastrointest. Tumors Pub Date : 2020-11-18 Jukka M. Rintala, Pirita R. Tahvonen, Saija T. Vuolio, Ilpo T. Typpö, Kai A. Suokanerva, Heikki I. Huhta
Introduction: Laparoscopic colorectal surgery has become widely used in treating colorectal cancer. Multicenter studies have shown that laparoscopy decreases postoperative complications and provides equivalent long-term oncological results compared to open surgery. Previous studies were conducted in high-volume institutions, with selected patients, which may influence the reported outcome of laparoscopy
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Lysyl Oxidase Mechanisms to Mediate Gastrointestinal Cancer Progression Gastrointest. Tumors Pub Date : 2020-11-10 Ahmadshah Farhat, Gordon A. Ferns, Korosh Ashrafi, Mohammad-Hassan Arjmand
Background: Malignancy is a complex process resulting from different changes such as extracellular matrix (ECM) remodeling and stiffness. One of the important enzymes that contribute to ECM remodeling is lysyl oxidase (Lox) that is overexpressed in different types of human cancers. Because of the high prevalence and poor survival of gastrointestinal (GI) malignancies in this review, we discuss the
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Short- and Long-Term Outcomes of Simultaneous Hepatic Artery Resection and Reconstruction for Perihilar Cholangiocarcinoma Gastrointest. Tumors Pub Date : 2020-11-10 Yoshitaro Shindo, Shogo Kobayashi, Hiroshi Wada, Yukio Tokumitsu, Satoshi Matsukuma, Hiroto Matsui, Masao Nakajima, Shin Yoshida, Michihisa Iida, Nobuaki Suzuki, Shigeru Takeda, Yoshinobu Hoshii, Hidetoshi Eguchi, Hiroaki Nagano
Introduction: Because surgical resection with simultaneous hepatic artery (HA) resection and reconstruction for perihilar cholangiocarcinoma (PHC) is technically demanding, the surgical indication for this challenging procedure is controversial. Thus, this study aimed to evaluate the efficacy of simultaneous HA resection and reconstruction for PHC. Methods: Between January 2002 and January 2018, 13
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Gastrointestinal Luminal Stenting: The Early US Experience with the Duodenal HANAROSTENT Gastrointest. Tumors Pub Date : 2020-10-09 Brian M. Fung, Brian E. Kadera, James H. Tabibian
Self-expandable metal stents (SEMSs) are frequently utilized for palliation of malignant gastric and/or duodenal outlet obstruction (GDOO). Re-establishing luminal patency with accurate SEMS positioning while limiting migration and adjacent tissue injury is an important technical consideration and aim. The duodenal HANAROSTENT® was introduced in the USA in 2019 and developed with these challenges in
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Colonic Carcinosarcoma: Report of a Rare Colorectal Malignancy and Review of Literature Gastrointest. Tumors Pub Date : 2020-10-06 Melissa Kyriakos Saad, Fatme Ghandour, Fatmeh Ghandour El Hajj, Imad El Hajj, Elias Saikaly
Colonic carcinosarcoma is an extremely rare tumor composed of mixed malignant epithelial and mesenchymal cells. Due to its rarity, its pathogenesis is poorly understood, and there are no specific guidelines for its treatment. Gastrointest Tumors
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Expression of AdipoR1 and AdipoR2 and Serum Level of Adiponectin in Gastric Cancer Gastrointest. Tumors Pub Date : 2020-09-16 Morteza Kordafshari, Mahyar Nourian, Narjes Mehrvar, Hassan Jalaeikhoo, Aida Etemadi, Ali Reza Khoshdel, Mohammad Ghaznavi Idris, Shahrokh Iravani, Azim Mehrvar
Background: Cancer is one of the major causes of death worldwide and the third leading cause of death in Iran. One of the proteins that are considered having anticancer effects is the adiponectin hormone. Adiponectin leads to programmed cell death, prevents cell growth and proliferation, and increases the expression levels of BCL2. Aim: The aim of this study was to assay the expression of adiponectin
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Recurrence of Hepatocellular Carcinoma in Hepatitis C Virus (HCV) Liver Transplant Recipients Treated with Pretransplant Direct-Acting Antiviral (DAA) Therapy Gastrointest. Tumors Pub Date : 2020-09-14 Nicholas Lim, Dupinder Singh, Scott Jackson, John R. Lake
Background: Direct-acting antivirals (DAAs) have revolutionized the treatment of hepatitis C virus (HCV). The impact of DAAs on recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) remains uncertain. Objective: We aimed to evaluate the risk of HCC recurrence in LT recipients cleared of HCV with DAAs at the time of LT compared to a control group of LT recipients who were viremic
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Long-Term Survival under Arterial Chemoembolization and Sorafenib of a Patient with Hepatocellular Carcinoma and Tumor Atrial Thrombus: A Case Report and Literature Review Gastrointest. Tumors Pub Date : 2020-08-18 Andreas Mavroudis, Evangelos Cholongitas
Hepatocellular carcinoma (HCC) is considered to be the fourth most frequent cause of cancer-associated death globally. HCC might be associated, especially in advanced stages, with the formation of tumor thrombus (TT), which can be located in the portal vein, as well as in hepatic and/or inferior vena cava (IVC) veins. Nevertheless, the extension of TT to the right atrium (RA) is infrequent with an
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Why Cannot BCLC 0- or A-Stage Patients Receive Curative Treatment? Gastrointest. Tumors Pub Date : 2020-08-13 Tse-Ming Kuo, Kai-Ming Chang, Kuo-Jang Kao
Introduction: Barcelona Clinic Liver Cancer (BCLC) staging has been an important clinical guideline for the management of hepatocellular carcinoma (HCC). BCLC 0 and A stages (BCLC 0/A) have been designated as the early-stage HCC, and the curative treatment is recommended as the primary therapeutic modality. However, a recent study indicated that a significant number of BCLC 0/A patients were not initially
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The Safety and Efficacy of Primary Duct Closure without Endoscopic Nasobiliary Drainage after Laparoscopic Common Bile Duct Exploration Gastrointest. Tumors Pub Date : 2020-08-12 Yan Yang, Lin Han, Da-Ning Lin, Zeng-Ji Hu, Wei Tu, Feng Chen, Yong-Qiang Li
Background: Primary duct closure (PDC) after laparoscopic common bile duct exploration (LCBDE) has been widely applied for choledocholithiasis. However, there has been controversy over the placement of endoscopic nasobiliary drainage (ENBD) during operation. To date, few studies compare the clinical effect of PDC without and with ENBD. The aim of this study was to assess the safety and efficacy of