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Non-Pure Intestinal Phenotype as an Indicator of Progression in Sporadic Non-ampullary Duodenal Adenomas: A Multicenter Retrospective Cohort Study. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-11-22 Ryotaro Uema,Yoshito Hayashi,Masato Komori,Narihiro Shibukawa,Noriko Hayashi,Masayoshi Horimoto,Takuya Yamada,Masashi Yamamoto,Satoshi Hiyama,Kazuo Kinoshita,Hideharu Ogiyama,Shinjiro Yamaguchi,Satoshi Egawa,Takashi Kanesaka,Minoru Kato,Shunsuke Yoshii,Yoshiki Tsujii,Honma Keiichiro,Shinichiro Shinzaki,Hideki Iijima,Eiichi Morii,Tetsuo Takehara
INTRODUCTION We aimed to evaluate the natural course of sporadic non-ampullary duodenal adenomas (SNDAs) and determine the risk factors of progression. METHODS We retrospectively analyzed the follow-up outcomes of patients with biopsy-diagnosed SNDA between April 2010 and March 2016 at 13 institutions. All initial biopsy specimens were centrally evaluated. Only those diagnosed with adenomas were included
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Mucosa-associated microbiota dysbiosis in the terminal ileum correlates with bowel symptoms in diarrhea-predominant irritable bowel syndrome. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-11-08 Bi-Yu Wu,Ping Xu,Li Cheng,Qian-Qian Wang,Hong-Yi Qiu,Xiu-Juan Yan,Sheng-Liang Chen
BACKGROUND AND AIMS The mucosa-associated microbiota (MAM) is not as frequently studied in diarrhea-predominant irritable bowel syndrome (IBS-D) compared to the fecal microbiota. Here, we examined the MAM in the terminal ileum and its correlation with bowel symptoms in IBS-D. METHODS Mucosal biopsies of the terminal ileum from 25 IBS-D patients and 25 healthy controls (HCs) were collected for 16S ribosomal
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Proton Pump Inhibitor use and Complications of Cirrhosis Are Linked with Distinct Gut Microbial Bacteriophage and Eukaryotic Viral Like Particle Signatures in Cirrhosis. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-11-08 Marcela Peña Rodríguez,Andrew Fagan,Masoumeh Sikaroodi,Patrick M Gillevet,Jasmohan S Bajaj
INTRODUCTION Proton pump inhibitors (PPI) modulate the progression of cirrhosis to hepatic encephalopathy (HE) and can affect the bacterial microbiome. However, the impact of PPI on the virome in cirrhosis using viral-like particle analysis (VLP) is unclear. METHOD We determined the VLP in the stool microbiome in cirrhosis cross-sectionally (ascites, HE, PPI use analyzed) who were followed up for 6-month
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Risk of anxiety, depression, and ADHD in pediatric patients with inflammatory bowel disease: A population-based cohort study. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-11-07 Rebecca Kristine Kappel,Tania Hviid Bisgaard,Gry Poulsen,Tine Jess
INTRODUCTION Inflammatory bowel disease (IBD) is associated with depression and anxiety in adults, but data is scarce on risk of psychiatric diseases in children with IBD. We aimed to estimate the risk of anxiety, depression, or attention-deficit/hyperactivity disorder in patients with pediatric-onset IBD. METHODS We performed a nationwide, register-based cohort study including all patients with pediatric-onset
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Microbiome-Based Therapeutics in Digestive Diseases: What They Are and How Are They Regulated. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-11-01 Shrinivas Bishu,Brian Ginnebaugh,Jacqueline Chu,Benjamin H Levy,
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Determination of Optimal Eosinophil Thresholds for Diagnosis of Eosinophilic Gastritis and Duodenitis: A Pooled Analysis of 4 Prospective Studies. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-10-20 Evan S Dellon,Enoch Bortey,Alan T Chang,Craig A Paterson,Kevin Turner,Robert M Genta
OBJECTIVES Consensus is lacking regarding the number of eosinophils (eos) required for diagnosis of eosinophilic gastritis (EoG) and eosinophilic duodenitis (EoD). Additionally, thresholds that require multiple high-power fields (hpfs) may not be practical for clinical use, resulting in delayed or missed diagnoses. This pooled analysis of 4 prospective studies assessed thresholds for multiple and single
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The diagnostic yield of genetic testing in patients with multiple colorectal adenomas: a specialist centre cohort study. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-10-10 Sau Mak,James L Alexander,Susan K Clark,Menna Hawkins,Victoria Cuthill,Andrew Latchford,Kevin J Monahan
BACKGROUND AND AIMS Adenoma multiplicity is associated with increased colorectal cancer (CRC) risk. The utility of genetic testing in multiple colorectal adenoma (MCRA) patients remains uncertain. We evaluated the diagnostic yield of mutations in polyposis and CRC associated genes in patients with MCRA. METHODS We performed a cross-sectional review of adult patients with 10-99 cumulative adenomas from
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Association of glycated hemoglobin with risk of pancreatic cancer in high-risk individuals based on genetic and family history. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-10-06 Bechien U Wu,Qiaoling Chen,Becky H Moon,Eva Lustigova,Erin G Nielsen,Monica Alvarado,Syed A Ahmed
BACKGROUND Screening for pancreatic cancer (PC) is suggested for high-risk individuals (HRI). Additional risk factors may enhance early detection in this population. METHODS Retrospective cohort study among patients with germline variants and/or familial pancreatic cancer in an integrated healthcare system between 2003-2019. We calculated incidence rate (IR) by risk category and performed a nested
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Lactulose versus polyethylene glycol for bowel preparation: a single-center, prospective, randomized controlled study based on the BMI. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-10-05 Sun Wenqi,Zhao Bei,Wang Yunrong,Wu Xinrong,Li Yifan,Wang Weiwei,Ni Muhan,Yan Peng,Dou Xiaotan,Li Wen,Yang Hua,Wang Lei,Chen Min
OBJECTIVE Colonoscopy is currently considered as one of the principal techniques to diagnose the colorectal diseases. Admittedly, qualified bowel preparation before colonoscopy is a premise for high-quality examination. Lower quality bowel preparation might seriously impede the visualization of the intestinal mucosa, resulting in missed and misdiagnosed intestinal lesions. Therefore, it is necessary
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Performance of Endoscopic Sleeve Gastroplasty by Obesity Class in the Clinical United States Setting. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-10-03 Khushboo Gala,Vitor Brunaldi,Christopher McGowan,Reem Z Sharaiha,Daniel Maselli,Brandon Vanderwel,Prashant Kedia,Michael Ujiki,Eric Wilson,Eric J Vargas,Andrew C Storm,Barham K Abu Dayyeh
INTRODUCTION Endoscopic sleeve gastroplasty (ESG) has gained popularity over the past decade and has been adopted in both academic and private institutions globally. We present outcomes of the largest cohort of patients from the United States undergoing ESG and evaluate these according to obesity class. METHODS We performed a retrospective analysis of adult patients who underwent ESG. Medical information
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Development and validation of serum markers as noninvasive diagnostic methods for achalasia. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-10-03 Xingyu Jia,Songfeng Chen,Xun Hou,Qianjun Zhuang,Niandi Tan,Mengyu Zhang,Jinhui Wang,Xiangbin Xing,Yinglian Xiao
BACKGROUND Currently, the diagnosis of achalasia mainly relies on invasive or radioactive examinations. This study aimed to develop a noninvasive diagnostic method for achalasia based on specific serum markers. METHODS Serum levels of profilin-1, galectin-10, immunoglobulin heavy variable (IGHV) 3-9, vasodilator-stimulated phosphoprotein (VASP) and transgelin-2 were measured in achalasia patients and
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The Use of Artificial Intelligence in Gastroenterology: A Glimpse Into the Present. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-10-01 Brian C Jacobson
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Development of Electronic Health Record-Based Machine Learning Models to Predict Barrett's Esophagus and Esophageal Adenocarcinoma Risk. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-10-01 Prasad G Iyer,Karan Sachdeva,Cadman L Leggett,D Chamil Codipilly,Halim Abbas,Kevin Anderson,John B Kisiel,Shahir Asfahan,Samir Awasthi,Praveen Anand,Praveen Kumar M,Shiv Pratap Singh,Sharad Shukla,Sairam Bade,Chandan Mahto,Navjeet Singh,Saurav Yadav,Chinmay Padhye
INTRODUCTION Screening for Barrett's esophagus (BE) is suggested in those with risk factors, but remains underutilized. BE/esophageal adenocarcinoma (EAC) risk prediction tools integrating multiple risk factors have been described. However, accuracy remains modest (area under the receiver-operating curve [AUROC] ≤0.7), and clinical implementation has been challenging. We aimed to develop machine learning
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Real-Time Evaluation of Helicobacter pylori Infection by Convolution Neural Network During White-Light Endoscopy: A Prospective, Multicenter Study (With Video). Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-10-01 Yuqin Shen,Angli Chen,Xinsen Zhang,Xingwei Zhong,Ahuo Ma,Jianping Wang,Xinjie Wang,Wenfang Zheng,Yingchao Sun,Lei Yue,Zhe Zhang,Xiaoyan Zhang,Ne Lin,John J Kim,Qin Du,Jiquan Liu,Weiling Hu
INTRODUCTION Convolutional neural network during endoscopy may facilitate evaluation of Helicobacter pylori infection without obtaining gastric biopsies. The aim of the study was to evaluate the diagnosis accuracy of a computer-aided decision support system for H. pylori infection (CADSS-HP) based on convolutional neural network under white-light endoscopy. METHODS Archived video recordings of upper
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Artificial Intelligence-Assisted Optical Diagnosis: A Comprehensive Review of Its Role in Leave-In-Situ and Resect-and-Discard Strategies in Colonoscopy. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-10-01 Maysaa El Zoghbi,Aasma Shaukat,Cesare Hassan,Joseph C Anderson,Alessandro Repici,Seth A Gross
Colorectal cancer screening plays a vital role in early detection and removal of precancerous adenomas, contributing to decreased mortality rates. Most polyps found during colonoscopies are small and unlikely to harbor advanced neoplasia or invasive cancer, leading to the development of "leave-in-situ" and "resect-and-discard" approaches. These strategies could lead to significant cost savings and
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Development and Validation of a Machine Learning System to Identify Reflux Events in Esophageal 24-Hour pH/Impedance Studies. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-10-01 Margaret J Zhou,Thomas Zikos,Karan Goel,Kabir Goel,Albert Gu,Christopher Re,David Jose Florez Rodriguez,John O Clarke,Patricia Garcia,Nielsen Fernandez-Becker,Irene Sonu,Afrin Kamal,Sidhartha R Sinha
INTRODUCTION Esophageal 24-hour pH/impedance testing is routinely performed to diagnose gastroesophageal reflux disease. Interpretation of these studies is time-intensive for expert physicians and has high inter-reader variability. There are no commercially available machine learning tools to assist with automated identification of reflux events in these studies. METHODS A machine learning system to
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A Randomized Controlled Study on Clinical Adherence to Evidence-Based Guidelines in the Management of Simulated Patients with Barrett's Esophagus and the Clinical Utility of a Tissue Systems Pathology Test: Results from Q-TAB. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-09-28 John W Peabody,Jamielyn D C Cruz,Divya Ganesan,David Paculdo,Rebecca J Critchley-Thorne,Sachin Wani,Nicholas J Shaheen
INTRODUCTION Barrett's esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Physicians infrequently adhere to guidelines for managing BE, leading to either reduced detection of dysplasia or inappropriate re-evaluation. METHODS We conducted a three-arm randomized controlled trial with two intervention arms to determine the impact of a tissue systems pathology (TSP-9) test on the adherence
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Serological Investigation of Persistent Villous Atrophy in Celiac Disease. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-09-27 Changlin Gong,Claudia Saborit,Xin Long,Ao Wang,Beishi Zheng,Howard Chung,Suzanne K Lewis,Suneeta Krishnareddy,Govind Bhagat,Peter H R Green,Xiao-Fei Kong
INTRODUCTION Persistent villous atrophy (VA) is not uncommon in celiac disease (CeD) while patients take a gluten-free diet (GFD). METHODS We conducted a retrospective study with 122 serum samples collected from controls and CeD patients either at the initial diagnosis or follow-up during endoscopy. These samples were assigned to three groups: non-celiac control, non-VA CeD (Marsh score 0-2), and VA
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TRAV26-2 T CELL RECEPTOR EXPRESSION IS ASSOCIATED WITH MUCOSAL LYMPHOCYTE RESPONSE TO WHEAT PROTEINS IN FUNCTIONAL DYSPEPSIA PATIENTS. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-09-27 Grace L Burns,Michael Potter,Andrea Mathe,Jessica Bruce,Kyra Minahan,Jessica L Barnes,Jennifer Pryor,Cheenie Nieva,Simonne Sherwin,Annalisa Cuskelly,Thomas Fairlie,Raquel Cameron,Steven Bollipo,Mudar Zand Irani,Robert Foster,Lay T Gan,Ayesha Shah,Natasha Koloski,Paul S Foster,Jay C Horvat,Marjorie M Walker,Nick Powell,Martin Veysey,Kerith Duncanson,Gerald Holtmann,Nicholas J Talley,Simon Keely
INTRODUCTION An association between functional dyspepsia (FD) and wheat-containing foods has been reported in observational studies, however, an adaptive response has not been demonstrated. We examined whether antigens present in wheat could provoke a response from FD duodenal lymphocytes. METHODS Lamina propria mononuclear cells (LPMCs) were isolated from duodenal biopsies from 50 FD patients and
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Dupilumab Can Induce Remission of Eosinophilic Gastritis and Duodenitis: A Retrospective Case Series. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-09-27 Twan Sia,Leeon Bacchus,Riki Tanaka,Raisa Khuda,Shibani Mallik,John Leung
INTRODUCTION Non-eosinophilic esophagitis eosinophilic gastrointestinal disorders (non-EoE-EGIDs) have limited treatment options to induce histologic and clinical remission. Dupilumab is a human monoclonal antibody against the interleukin-4 receptor ɑ subunit, which has been reported to induce improvement in pediatric patients with non-EoE-EGIDs. METHODS We conducted a retrospective chart review to
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Comparative effectiveness of tacrolimus and infliximab in hospitalized patients with ulcerative colitis. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-09-27 Takahiro Takahashi,Hisashi Shiga,Kunio Tarasawa,Yusuke Shimoyama,Takeo Naito,Rintaro Moroi,Masatake Kuroha,Yoichi Kakuta,Kiyohide Fushimi,Kenji Fujimori,Yoshitaka Kinouchi,Atsushi Masamune
INTRODUCTION Cyclosporine or infliximab (IFX) have been used to avoid surgery in patients with severe refractory ulcerative colitis (UC). Tacrolimus (Tac) is occasionally used as an alternative to cyclosporine; however, the comparative efficacy of Tac and IFX has not been reported. We aimed to compare the effectiveness of Tac and IFX in hospitalized UC patients. METHODS In a propensity score (PS)-matched
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Esophageal Function and Reflux Evaluations in Lung Transplantation: A Nationwide Survey of UNOS Accredited Transplant Centers in the US. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-09-25 Ryan Leung,Wai-Kit Lo,Nirmal S Sharma,Hilary J Goldberg,Walter W Chan
BACKGROUND Gastroesophageal reflux disease has been associated with worse lung transplant outcomes. We aimed to assess local practices for esophageal function testing (EFT) across transplant centers. METHODS Survey study of all UNOS-accredited adult lung transplant centers regarding local EFT practice. RESULTS Among 39/63 (60%) responded centers, 38.5% required any EFT (35.9% esophageal manometry,
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Engineering an Accurate Model of Portal Hypertension: Simulation With a Goal of Clinical Impact. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-09-01 Arun B Jesudian
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Baseline peripheral blood mononuclear cell (PBMC) transcriptomics before ustekinumab treatment is linked with Crohn Disease clinical response at 1 year. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-09-01 Maya Granot,Tzipi Braun,Gilat Efroni,Orit Picard,Ella Fudim,Miri Yavzori,Ola Haj,Batia Weiss,Shomron Ben-Horin,Uri Kopylov,Yael Haberman
BACKGROUND/OBJECTIVES Ustekinumab (Stelara), a monoclonal antibody to the p40 subunit of interleukin-12 and interleukin-23, is used for Crohn Disease (CD), and the documented clinical remission rate after one year was observed in about 50% of patients. We aimed to identify predictors for a clinical response using peripheral blood obtained from CD patients just before ustekinumab treatment initiation
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Maternal Vitamin A Status as a Risk Factor of Hirschsprung Disease in the Child. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-09-01 Shalini G Hegde,Sarita Devi,Ambily Sivadas,Attibele Mahadevaiah Shubha,Annamma Thomas,Arpita Mukhopadhyay,Anura V Kurpad
INTRODUCTION The gene-environment interaction of the REarranged during Transfection ( RET ) gene with vitamin A in the etiopathogenesis of Hirschsprung disease (HSCR) has been suggested in rodents. The aim of this study was to evaluate vitamin A status in mothers of children with HSCR and to assess its association with pathogenic variants of the RET gene in affected children. METHODS This was a case-control
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A Tissue Systems Pathology Test Outperforms the Standard-of-Care Variables in Predicting Progression in Patients With Barrett's Esophagus. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-11-01 Jon M Davison,John R Goldblum,Lucas C Duits,Amir M Khoshiwal,Jacques J Bergman,Gary W Falk,David L Diehl,Harshit S Khara,Christian Smolko,Meenakshi Arora,Jennifer J Siegel,Rebecca J Critchley-Thorne,Prashanthi N Thota
INTRODUCTION Objective risk stratification is needed for patients with Barrett's esophagus (BE) to enable risk-aligned management to improve health outcomes. This study evaluated the predictive performance of a tissue systems pathology [TSP-9] test (TissueCypher) vs current clinicopathologic variables in a multicenter cohort of patients with BE. METHODS Data from 699 patients with BE from 5 published
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Terlipressin versus Midodrine plus Octreotide for Hepatorenal Syndrome-Acute Kidney Injury: A Propensity Score-Matched Comparison. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-08-25 Stevan A Gonzalez,Viktor V Chirikov,Wei-Jhih Wang,Xingyue Huang,Khurram Jamil,Douglas A Simonetto
OBJECTIVES Evidence on the comparison of treatments for hepatorenal syndrome-acute kidney injury (HRS-AKI) in a US population is limited. An indirect comparison of terlipressin plus albumin versus midodrine and octreotide plus albumin (MO) may provide further insight into treatment efficacy. METHODS Cohorts of patients treated for HRS-AKI characterized by serum creatinine [SCr] < 5 mg/dL, baseline
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Bile acid sequestrant use and gastric cancer: A national retrospective cohort analysis. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-08-22 Andrew Canakis,Amy Lee,Alese E Halvorson,Jennifer M Noto,Richard M Peek,Otis Wilson,Adriana Hung,Christianne L Roumie,Robert Greevy,Shailja C Shah
INTRODUCTION Bile acids have been implicated in gastric carcinogenesis. We hypothesized that bile acid sequestrant medication (BAM) use is associated with a lower gastric cancer (GC) incidence. METHODS We assembled a cohort of Veterans receiving longitudinal care within the Veterans Health Administration (VHA) between 2000-2020 who completed testing for H. pylori. The index date was the date of completed
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Mirikizumab-Induced Transcriptome Changes in Ulcerative Colitis Patient Biopsies at Week 12 Are Maintained Through Week 52. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-11-01 Travis Johnson,Boyd Steere,Pengyue Zhang,Yong Zang,Richard Higgs,Catherine Milch,Walter Reinisch,Julian Panés,Kun Huang,Geert D'Haens,Venkatesh Krishnan
INTRODUCTION Mirikizumab, an anti-interleukin-23p19 monoclonal antibody, demonstrated efficacy in phase 2 and 3 randomized clinical trials of patients with moderate-to-severe ulcerative colitis (UC). Previous results have shown that 12 weeks of mirikizumab treatment downregulated transcripts associated with UC disease activity and tumor necrosis factor inhibitor resistance. We assessed week-52 gene
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Gastric Alimetry in the Management of Chronic Gastroduodenal Disorders: Impact to Diagnosis and Health Care Utilization. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-11-01 Chris Varghese,Charlotte Daker,Alexandria Lim,Gabrielle Sebaratnam,William Xu,Bernard Kean,Chris Cederwall
INTRODUCTION Chronic gastroduodenal symptoms are frequently overlapping within existing diagnostic paradigms, and current diagnostic tests are insensitive to underlying pathophysiologies. Gastric Alimetry has emerged as a new diagnostic test of gastric neuromuscular function with time-of-test symptom profiling. This study aimed to assess the impact to diagnosis and health care utilization after the
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The effect of using Premedication of simethicone/pronase with or without Postural Change on Visualization of the Mucosa before Endoscopy: A prospective, double blinded, randomized controlled trial. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-08-15 Li Cao,Fangqin Zheng,Deqiong Wang,Li Chen,Xinxia Feng,Zhenzhen Zhou,Jingmei Liu,Mi Wang,Qiaozhen Guo,Mei Liu
INTRODUCTION To investigate the efficacy and safety of preprocedural simethicone (S) and pronase (P) for optimal mucosal visualization during esophagogastroduodenoscopy (EGD) with sedation. The effect of postural change combined with premedication on mucosal visibility was also examined. METHODS The study randomized 496 patients into 8 groups based on the type of premedication provided and whether
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A Comparison of Treatment Effect Sizes in Matched Phase 2 and Phase 3 Trials of Advanced Therapeutics in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-11-01 Jurij Hanzel,Virginia Solitano,Lily Zou,G Y Zou,Laurent Peyrin-Biroulet,Silvio Danese,Siddharth Singh,Christopher Ma,Pauline Wils,Vipul Jairath
INTRODUCTION Phase 2 trials are fundamental to the rational and efficient design of phase 3 trials. We aimed to determine the relationship of treatment effect size estimates from phase 2 and phase 3 clinical trials on advanced therapeutics in inflammatory bowel disease. METHODS MEDLINE, EMBASE, CENTRAL, and the Cochrane library were searched from inception to December 19, 2022, to identify paired phase
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Gastrointestinal sensory neuropathy and dysmotility in Fabry disease: Presentations and effect on patient's quality of life. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-08-14 Nir Bar,Amel Karaa,Katheryn Kiser,Claire Zar-Kessler,Braden Kuo
INTRODUCTION Fabry disease is a rare multisystemic lysosomal disease resulting in variable manifestations of the gastrointestinal (GI), neurologic, cardiac, and renal systems. Whether GI manifestations are a result of gut dysmotility is undetermined. We aimed to explore GI manifestations in depth, their effect on patients with Fabry disease, and to characterize gut motility. METHODS We recruited adult
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Comparative Efficacy of Tegoprazan vs Esomeprazole/Sodium Bicarbonate for the Treatment of Helicobacter pylori Infection. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-11-01 Chan Hyuk Park,Jung Ho Park,Yoon Suk Jung
INTRODUCTION Potassium-competitive acid blockers and proton pump inhibitors/sodium bicarbonate can rapidly increase intragastric pH. In this study, we aimed to compare the clinical outcomes of tegoprazan-based and esomeprazole/sodium bicarbonate-based triple therapies in the treatment of Helicobacter pylori infection. METHODS We retrospectively reviewed the data of patients with H. pylori infection
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Temporal Analysis of Inflammatory Bowel Disease and Pancreatitis Co-Occurrence in Children and Adults in the United States. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-11-01 Ke-You Zhang,Ismaeel Siddiqi,Michelle Saad,Tatiana Balabanis,Melody S Dehghan,Alexander Nasr,Vania Tolj,Aida Habtezion,K T Park,Maisam Abu-El-Haija,Zachary M Sellers
INTRODUCTION Pancreatitis in inflammatory bowel disease has been attributed to peripancreatic intestinal disease and/or drug-induced pancreatic toxicity. We used large cohort analyses to define inflammatory bowel disease and pancreatitis temporal co-occurrence with a detailed descriptive analysis to gain greater insight into the pathophysiological relationship between these 2 diseases. METHODS Truven
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Fecal Biomarkers of Neutrophil and Eosinophil Origin Reflect the Response to Biological Therapy and Corticosteroids in Patients With Inflammatory Bowel Disease. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-08-01 Maria Ling Lundström,Christer Peterson,Maria Lampinen,Charlotte R H Hedin,Åsa V Keita,Robert Kruse,Maria K Magnusson,Carl Mårten Lindqvist,Dirk Repsilber,Mauro D'Amato,Henrik Hjortswang,Hans Strid,Anders Rönnblom,Johan D Söderholm,Lena Öhman,Per Venge,Jonas Halfvarson,Marie Carlson,
INTRODUCTION Fecal calprotectin (FC) is a noninvasive tool for examining response to biologics in inflammatory bowel disease (IBD), but its performance in relation to other novel fecal markers of various cellular origins is unknown. METHODS We performed a prospective multicenter cohort study and included patients with active IBD who provided a fecal sample at initiation of biological therapy. Levels
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IL-6-Dependent STAT3 Activation and Induction of Proinflammatory Cytokines in Primary Sclerosing Cholangitis. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-08-01 Leona Dold,Leonie Frank,Philipp Lutz,Dominik J Kaczmarek,Benjamin Krämer,Jacob Nattermann,Tobias J Weismüller,Vittorio Branchi,Marieta Toma,Maria Gonzalez-Carmona,Christian P Strassburg,Ulrich Spengler,Bettina Langhans
INTRODUCTION Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease with periductal inflammation and fibrosis. Genetic studies suggest inflammatory cytokines and IL-6-dependent activation of transcription factor STAT3 as pivotal steps in PSC pathogenesis. However, details of inflammatory regulation remain unclear. METHODS We recruited 50 patients with PSC (36 with inflammatory bowel
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Prevalence of and factors associated with extraintestinal manifestations and their remission in inflammatory bowel disease: the EXTRA prospective study from the GETAID. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-08-01 Lucas Guillo,Guillaume Savoye,Aurélien Amiot,Cyrielle Gilletta,Maria Nachury,Nina Dib,Arnaud Bourreille,Xavier Roblin,Ludovic Caillo,Matthieu Allez,Laurence Picon,Xavier Hébuterne,Philippe Seksik,Antoine Chupin,Anthony Buisson,Hédia Brixi,Romain Altwegg,Marion Simon,Morgane Amil,David Laharie,Guillaume Bouguen,Mélanie Serrero,Yasmine Elgharabawy,Laurent Peyrin-Biroulet
BACKGROUND AND AIMS Extraintestinal manifestations (EIM) of inflammatory bowel disease (IBD) are challenging clinical situation. No prospective study assessed remission risk factors for EIMs. Study aimed to prospectively investigate the epidemiology, risk factors for EIM occurrence and EIM remission in a large IBD cohort. METHODS We conducted a cross-sectional study in 30 French referral centers. Between
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Prevalence of Osteopathy in Chronic Pancreatitis: A Systematic Review and Meta-Analysis. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-08-01 Daryl Ramai,Antonio Facciorusso,Marcello Maida,Gabriele Capurso,Saurabh Chandan,Marco Spadaccini,Roberta Elisa Rossi,Cesare Hassan,Alessandro Repici,Sinead Duggan,Darwin L Conwell,Phil A Hart
INTRODUCTION Individuals with chronic pancreatitis (CP) are at increased risk for nutritional complications during their clinical course. We appraised the literature to provide updated estimates of the prevalence and predictors of osteoporosis, osteopenia, and osteopathy in CP using a systematic review and meta-analysis. METHODS Search strategies were developed for major databases from inception through
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Use of a Mobile-Assisted Telehealth Regimen to Increase Exercise in Transplant Candidates: A Home-Based Prehabilitation Pilot and Feasibility Trial. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-11-01 Andres Duarte-Rojo,Pamela M Bloomer,Rachel K Grubbs,Jonathan G Stine,Daniela Ladner,Christopher B Hughes,Michael A Dunn,John M Jakicic
INTRODUCTION Physical fitness assessed by the Liver Frailty Index (LFI) and 6-minute walk test (6MWT) informs the prognosis of liver transplant candidates, although there are limited data on its reversibility after prehabilitation. On a home-based exercise trial, we aimed to improve LFI and 6MWT and to investigate trial feasibility and intervention adherence. METHODS Liver transplant candidates with
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The Clinical Characteristics and Related Factors of Centrally Mediated Abdominal Pain Syndrome. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-11-01 Tang Yuming,Song Jiani,Chen Hefeng,Zhu Ying,Yao Weiyan,Zou Duowu
INTRODUCTION The aim of this study was to explore the clinical characteristics and related factors of centrally mediated abdominal pain syndrome (CAPS). METHODS Our study included 73 patients with CAPS and 132 age-matched and gender-matched healthy controls. The general information of the participants was collected, and the questionnaires were completed including the 7-item Generalized Anxiety Disorder
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Prevalence of Immunomodulator Use as Combination Therapy With Vedolizumab or Ustekinumab in Inflammatory Bowel Disease. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-11-01 Megan Lutz,Freddy Caldera,Katie Schroeder,Derek Gazis,Julie M Crawford,Millie D Long,Edward L Barnes
INTRODUCTION The benefit of adding an immunomodulator to vedolizumab and ustekinumab remains unclear and may compromise the safety of these biologics. We evaluated the prevalence and predictors of immunomodulator use with vedolizumab or ustekinumab in patients with inflammatory bowel disease in a large longitudinal cohort. METHODS Clinical information was ascertained from electronic medical records
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Landscape of Psychological Profiles in Patients With Esophageal Achalasia. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-11-01 Jia-Qi Xu,Zi-Han Geng,Zu-Qiang Liu,Lu Yao,Zhao-Chao Zhang,Yun-Shi Zhong,Yi-Qun Zhang,Jian-Wei Hu,Ming-Yan Cai,Li-Qing Yao,Quan-Lin Li,Ping-Hong Zhou
INTRODUCTION Esophageal achalasia (EA) is a chronic esophageal dysmotility disease, of which psychological distress was poorly understood. This study aims to assess the status of psychosocial characteristics in EA and to determine the relationship between psychological distress and EA. METHODS Seventy pairs of age and gender-matched patients with EA and healthy control individuals were prospectively
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Novel Genetic Risk Variants and Clinical Predictors Associated With Primary Sclerosing Cholangitis in Patients With Ulcerative Colitis. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-09-01 Ming-Hsi Wang,Jessica J Friton,Nancy Rebert,Kelly Monroe,Billy D Nix,Claudio Fiocchi,Laura E Raffals,Jonathan A Leighton,Shabana F Pasha,Michael F Picco,Rodney D Newberry,Jean-Paul Achkar,William A Faubion
INTRODUCTION Patients with ulcerative colitis (UC) who are likely to have primary sclerosing cholangitis (PSC) should be identified because PSC can influence UC clinical behavior and outcomes.The aim of this study was to establish a model incorporating clinical and genetic risk predictors that identifies patients with UC at risk of developing PSC. METHODS We conducted a retrospective case-control study
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Fecal Calprotectin for the Diagnosis and Management of Inflammatory Bowel Diseases. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-09-01 Nathalie Kapel,Hamza Ouni,Nacer Adam Benahmed,Laurence Barbot-Trystram
Calprotectin is a heterodimeric calcium- and zinc-binding protein mainly derived from the cytoplasm of neutrophils that has direct antimicrobial functions and a role in the regulation of the innate immune response. It can be found in various biological compartments, in particular, the stool, with concentrations related to the level of mucosal inflammation. The measurement of fecal calprotectin has
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Drug-Induced Acute Pancreatitis: An Evidence-Based Classification (Revised). Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-08-01 Jasmine Saini,Daniel Marino,Nison Badalov,Melanie Vugelman,Scott Tenner
INTRODUCTION Drug induced acute pancreatitis is a difficult diagnosis for clinicians. We previously published an "Evidence-Based Classification System" on Drug-Induced Acute Pancreatitis widely used by clinicians to assist in the identification of drugs. Unfortunately, this prior analysis based only on published case reports has been misunderstood. The prior review did not include studies with higher
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Validation of Epigenetic Markers for the Prediction of Response to Topical Corticosteroid Treatment in Eosinophilic Esophagitis. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-09-01 Elizabeth T Jensen,Carl D Langefeld,Timothy D Howard,Evan S Dellon
INTRODUCTION We previously identified 18 CpG methylation biomarkers associated with treatment response to topical corticosteroids (tCS) in eosinophilic esophagitis (EoE). In this study, in an independent cohort, we assessed the validity of these CpG sites as treatment response biomarkers. METHODS DNA was extracted from prospectively biobanked esophageal biopsies from patients with newly diagnosed EoE
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Using Artificial Intelligence to Predict Cirrhosis From Computed Tomography Scans. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-10-01 Nikhilesh R Mazumder,Binu Enchakalody,Peng Zhang,Grace L Su
INTRODUCTION Undiagnosed cirrhosis remains a significant problem. In this study, we developed and tested an automated liver segmentation tool to predict the presence of cirrhosis in a population of patients with paired liver biopsy and computed tomography (CT) scans. METHODS We used a cohort of 1,590 CT scans within the Morphomics database to train an automated liver segmentation model using 3D-U-Net
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Long-Term Follow-Up of Colonoscopy Quality Monitoring. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-09-01 Feenalie Patel,Christen Dilly,Nabil Fayad,Smitha Marri,George J Eckert,Charles Kahi
INTRODUCTION High-quality colonoscopy is paramount for colorectal cancer prevention. Since 2009, endoscopists at our institution have received quarterly report cards summarizing individual colonoscopy quality indicators. We have previously shown that implementing this intervention was associated with short-term improvement in adenoma detection rate (ADR). However, the long-term effect of continued
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Clinical Significance of Ascitic Fluid Polymorphonuclear Leukocyte Percentage in Patients With Cirrhosis Without Spontaneous Bacterial Peritonitis. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-09-01 Lillian Dawit,Vivian Lee,David Lehoang,Cameron Furey,Aneesa Chowdhury,Thu Anne Mai,Varun Angajala,Joo Hye Park,Kevork Khadarian,Rosemary She,Maria Vergara-Lluri,Jeffrey Kahn,Jennifer L Dodge,Takeshi Saito
INTRODUCTION Absolute polymorphonuclear leukocyte (PMN) count (PMN-C) ≥250 cells/mm 3 in ascites is the diagnostic hallmark of spontaneous bacterial peritonitis (SBP) and is associated with high morbidity and mortality. However, the clinical significance of ascitic PMN percentage (PMN-%) and PMN-C in the absence of SBP as additional biomarkers for mortality and future incidence of SBP has not been
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Deep Learning and Minimally Invasive Endoscopy: Automatic Classification of Pleomorphic Gastric Lesions in Capsule Endoscopy. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-10-01 Miguel Mascarenhas,Francisco Mendes,Tiago Ribeiro,João Afonso,Pedro Cardoso,Miguel Martins,Hélder Cardoso,Patrícia Andrade,João Ferreira,Miguel Mascarenhas Saraiva,Guilherme Macedo
INTRODUCTION Capsule endoscopy (CE) is a minimally invasive examination for evaluating the gastrointestinal tract. However, its diagnostic yield for detecting gastric lesions is suboptimal. Convolutional neural networks (CNNs) are artificial intelligence models with great performance for image analysis. Nonetheless, their role in gastric evaluation by wireless CE (WCE) has not been explored. METHODS
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Association of Helicobacter pylori Positivity With Risk of Disease and Mortality. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-09-01 Jonas Wizenty,Paul-Henry Koop,Jan Clusmann,Frank Tacke,Christian Trautwein,Kai Markus Schneider,Michael Sigal,Carolin V Schneider
INTRODUCTION Helicobacter pylori colonizes the human stomach. Infection causes chronic gastritis and increases the risk of gastroduodenal ulcer and gastric cancer. Its chronic colonization in the stomach triggers aberrant epithelial and inflammatory signals that are also associated with systemic alterations. METHODS Using a PheWAS analysis in more than 8,000 participants in the community-based UK Biobank
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Polyps and Colorectal Cancer in Serrated Polyposis Syndrome: Contribution of the Classical Adenoma-Carcinoma and Serrated Neoplasia Pathways. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-08-01 David E F W M van Toledo,Joep E G IJspeert,Hannah Boersma,Alex R Musler,Arne G C Bleijenberg,Evelien Dekker,Carel J M van Noesel
INTRODUCTION Patients with serrated polyposis syndrome (SPS) have an increased risk to develop colorectal cancer (CRC). Due to an abundance of serrated polyps, these CRCs are assumed to arise mainly through the serrated neoplasia pathway rather than through the classical adenoma-carcinoma pathway. We aimed to evaluate the pathogenetic routes of CRCs in patients with SPS. METHODS We collected endoscopy
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Setting 6-Minute Minimal Examination Time Improves the Detection of Focal Upper Gastrointestinal Tract Lesions During Endoscopy: A Multicenter Prospective Study. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-08-01 Ye Gao,Meng-Xi Cai,Bo Tian,Han Lin,Zhen-Yu Jiang,Xiao-Cui Yang,Lin Lu,Li Li,Li-Hong Shi,Xiao-Yu Liu,Yi-Lin Wang,Zhao-Shen Li,Lei Xin,Luo-Wei Wang
INTRODUCTION Positive correlation between examination time and neoplasm detection using esophagogastroduodenoscopy (EGD) has been described by observational studies, but the effect of setting minimal examination time still requires investigation. METHODS This prospective, 2-stage, interventional study was conducted in 7 tertiary hospitals in China, enrolling consecutive patients undergoing intravenously
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Human-Like Artificial Intelligent System for Predicting Invasion Depth of Esophageal Squamous Cell Carcinoma Using Magnifying Narrow-Band Imaging Endoscopy: A Retrospective Multicenter Study. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-10-01 Lihui Zhang,Renquan Luo,Dehua Tang,Jie Zhang,Yuchen Su,Xinli Mao,Liping Ye,Liwen Yao,Wei Zhou,Jie Zhou,Zihua Lu,Mengjiao Zhang,Youming Xu,Yunchao Deng,Xu Huang,Chunping He,Yong Xiao,Junxiao Wang,Lianlian Wu,Jia Li,Xiaoping Zou,Honggang Yu
INTRODUCTION Endoscopic evaluation is crucial for predicting the invasion depth of esophagus squamous cell carcinoma (ESCC) and selecting appropriate treatment strategies. Our study aimed to develop and validate an interpretable artificial intelligence-based invasion depth prediction system (AI-IDPS) for ESCC. METHODS We reviewed the PubMed for eligible studies and collected potential visual feature
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Postnatal Dynamics and Clinical Associations of Fecal Calprotectin in Very Preterm Infants: Implications for Necrotizing Enterocolitis and Feeding Intolerance. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-08-01 Luyang Hong,Yihuang Huang,Siyuan Jiang,Junyan Han,Shujuan Li,Lan Zhang,Qi Zhou,Xincheng Cao,Weiyin Yu,Yi Yang,Yun Cao
INTRODUCTION To elucidate the postnatal dynamics and clinical associations of fecal calprotectin (FC) in very preterm infants, with a focus on necrotizing enterocolitis (NEC) and feeding intolerance (FI). METHODS We performed a prospective observational cohort study in infants with a gestational age of <32 weeks or birth weight <1,500 g with weekly feces collection. The relationships between FC, NEC
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Dietary Calcium and Risk of Microscopic Colitis. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-06-01 Robert S Sandler,Shan Sun,Temitope O Keku,John T Woosley,Chelsea Anderson,Anne F Peery,Anthony Fodor
BACKGROUND Microscopic colitis (MC) is an increasingly common cause of watery diarrhea particularly in older individuals. The role of diet in MC has received little study. METHODS We conducted a case-control study at a single institution enrolling patients referred for elective outpatient colonoscopy for diarrhea. Patients were classified as cases with MC or non-MC controls after a review of colon
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Efficacy and Safety of Keverprazan Compared With Lansoprazole in the Treatment of Duodenal Ulcer: A Phase III, Randomized, Double-Blind, Multicenter Trial. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-07-01 Nian-di Tan,Xin-Pu Miao,Ai-Jun Liao,Cheng-Xia Liu,Hao Wu,Hong-Hui Chen,Fang-Fang Li,Qing-Hong Guo,Sheng-Bao Li,Yan-Ping Tang,Min Xia,You-Li Liu,Xing Li,Hui-Xin Chen,Xiao-Wei Liu,Yan Zhang,Zhen-Yu Zhang,Min-Hu Chen,Ying-Lian Xiao
INTRODUCTION Keverprazan is a novel potassium-competitive acid blocker for the treatment of acid-related disorders requiring potent acid inhibition. This study aimed to establish the noninferiority of keverprazan to lansoprazole in the treatment of patients with duodenal ulcer (DU). METHODS In this phase III, double-blind, multicenter study, 360 Chinese patients with endoscopically confirmed active
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Association Between Patient-Level, Clinic-Level, and Geographical-Level Factors and 1-Year Surveillance Colonoscopy Adherence. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-07-01 Talicia Savage,Qin Sun,Ari Bell-Brown,Anjali Katta,Veena Shankaran,Catherine Fedorenko,Scott D Ramsey,Rachel B Issaka
INTRODUCTION Surveillance colonoscopy 1 year after surgical resection for patients with stages I-III colorectal cancer (CRC) is suboptimal, and data on factors associated with lack of adherence are limited. Using surveillance colonoscopy data from Washington state, we aimed to determine the patient, clinic, and geographical factors associated with adherence. METHODS Using administrative insurance claims
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Diet, Gut Microbiome, and Their End Metabolites Associate With Acute Pancreatitis Risk. Clin. Transl. Gastroen. (IF 3.6) Pub Date : 2023-07-01 Cemal Yazici,Sarang Thaker,Karla K Castellanos,Haya Al Rashdan,Yongchao Huang,Paya Sarraf,Brian Boulay,Paul Grippo,H Rex Gaskins,Kirstie K Danielson,Georgios I Papachristou,Lisa Tussing-Humphreys,Yang Dai,Ece R Mutlu,Brian T Layden
INTRODUCTION Diet and decreased gut microbiome diversity has been associated with acute pancreatitis (AP) risk. However, differences in dietary intake, gut microbiome, and their impact on microbial end metabolites have not been studied in AP. We aimed to determine differences in (i) dietary intake (ii) gut microbiome diversity and sulfidogenic bacterial abundance, and (iii) serum short-chain fatty