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Tumour response following preoperative chemotherapy is affected by body mass index in patients with colorectal liver metastases. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Hua-Chuan Song, Hang-Cheng Zhou, Ping Gu, Bing Bao, Quan Sun, Tian-Ming Mei, Wei Cui, Kang Yao, Huan-Zhang Yao, Shen-Yu Zhang, Yong-Shuai Wang, Rui-Peng Song, Ji-Zhou Wang
Colorectal cancer is the third most prevalent malignancy globally and ranks second in cancer-related mortality, with the liver being the primary organ of metastasis. Preoperative chemotherapy is widely recommended for initially or potentially resectable colorectal liver metastases (CRLMs). Tumour pathological response serves as the most important and intuitive indicator for assessing the efficacy of
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Effect of different anesthetic modalities with multimodal analgesia on postoperative pain level in colorectal tumor patients. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Ji-Chun Tang, Jia-Wei Ma, Jin-Jin Jian, Jie Shen, Liang-Liang Cao
According to clinical data, a significant percentage of patients experience pain after surgery, highlighting the importance of alleviating postoperative pain. The current approach involves intravenous self-control analgesia, often utilizing opioid analgesics such as morphine, sufentanil, and fentanyl. Surgery for colorectal cancer typically involves general anesthesia. Therefore, optimizing anesthetic
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Hepatomegaly and jaundice as the presenting symptoms of systemic light-chain amyloidosis: A case report. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Xu Zhang, Fei Tang, Yan-Ying Gao, De-Zhao Song, Jing Liang
Light chain (AL) amyloidosis is a plasma cell dyscrasia characterized by the pathologic production and extracellular tissue deposition of fibrillar proteins derived from immunoglobulin AL fragments secreted by a clone of plasma cells, which leads to progressive dysfunction of the affected organs. The two most commonly affected organs are the heart and kidneys, and liver is rarely the dominant affected
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Comprehensive analysis of the potential pathogenesis of COVID-19 infection and liver cancer. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Yao Rong, Ming-Zheng Tang, Song-Hua Liu, Xiao-Feng Li, Hui Cai
A growing number of clinical examples suggest that coronavirus disease 2019 (COVID-19) appears to have an impact on the treatment of patients with liver cancer compared to the normal population, and the prevalence of COVID-19 is significantly higher in patients with liver cancer. However, this mechanism of action has not been clarified.
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Large isolated fibrous tumors in the upper esophagus: A case report. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Jia-Jia Yu, Huan-Shuang Pei, Yu Meng
Solitary fibrous tumors (SFT) are rare spindle cell tumors that are usually benign. A total of 10 cases of SFTs in the upper esophagus have ever been reported. Here, we report the anesthetic management of a patient with a large isolated fibrous tumor of the upper esophagus compressing the tracheal membrane. We also provide a literature review of the current research.
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Prognostic nutritional index in predicting survival of patients with gastric or gastroesophageal junction adenocarcinoma: A systematic review. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Stylianos Fiflis, Grigorios Christodoulidis, Menelaos Papakonstantinou, Alexandros Giakoustidis, Stergos Koukias, Paraskevi Roussos, Marina Nektaria Kouliou, Konstantinos Eleftherios Koumarelas, Dimitrios Giakoustidis
Gastric cancer is the third most common cause of cancer related death worldwide. Surgery with or without chemotherapy is the most common approach with curative intent; however, the prognosis is poor as mortality rates remain high. Several indexes have been proposed in the past few years in order to estimate the survival of patients undergoing gastrectomy. The preoperative nutritional status of gastric
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Biological factors driving colorectal cancer metastasis. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Shuai-Xing An, Zhao-Jin Yu, Chen Fu, Min-Jie Wei, Long-Hai Shen
Approximately 20% of colorectal cancer (CRC) patients present with metastasis at diagnosis. Among Stage I-III CRC patients who undergo surgical resection, 18% typically suffer from distal metastasis within the first three years following initial treatment. The median survival duration after the diagnosis of metastatic CRC (mCRC) is only 9 mo. mCRC is traditionally considered to be an advanced stage
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Identification of anti-gastric cancer effects and molecular mechanisms of resveratrol: From network pharmacology and bioinformatics to experimental validation. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Ying-Qian Ma, Ming Zhang, Zhen-Hua Sun, Hong-Yue Tang, Ying Wang, Jiang-Xue Liu, Zhan-Xue Zhang, Chao Wang
Gastric cancer (GC) is one of the most aggressive malignancies with limited therapeutic options and a poor prognosis. Resveratrol, a non-flavonoid polyphenolic compound found in a variety of Chinese medicinal materials, has shown excellent anti-GC effect. However, its exact mechanisms of action in GC have not been clarified.
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Targeting oxidative stress with natural products: A novel strategy for esophageal cancer therapy. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Fang Cao, Han-Ling Zhang, Cui Guo, Xue-Liang Xu, Qiang Yuan
Esophageal cancer (ESC) is a malignant tumor that originates from the mucosal epithelium of the esophagus and is part of the digestive tract. Although the exact pathogenesis of ESC has not been fully elucidated, excessive oxidative stress is an important characteristic that leads to the development of many cancers. Abnormal expression of several proteins and transcription factors contributes to oxidative
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Preoperative controlling nutritional status as an optimal prognostic nutritional index to predict the outcome for colorectal cancer. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Li-Xiang Liu, Hao Wang, Bo Gao, Ting-Ting Xu, Qing-Gang Yuan, Shi-Zhen Zhou, Chao Ding, Ji Miao, Wen-Xian Guan
The controlling nutritional status (CONUT) score effectively reflects a patient's nutritional status, which is closely related to cancer prognosis. This study investigated the relationship between the CONUT score and prognosis after radical surgery for colorectal cancer, and compared the predictive ability of the CONUT score with other indexes.
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Effect of screening colonoscopy frequency on colorectal cancer mortality in patients with a family history of colorectal cancer. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Li Zheng, Bin Li, Ling Lei, Li-Jia Wang, Zhi-Ping Zeng, Jian-Dong Yang
Colorectal cancer is a common malignant tumor in China, and its incidence in the elderly is increasing annually. Inflammatory bowel disease is a group of chronic non-specific intestinal inflammatory diseases, including ulcerative colitis and Crohn's disease.
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Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOM trial. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Vilma Pacheco-Barcia, Sara Custodio-Cabello, Fatima Carrasco-Valero, Magda Palka-Kotlowska, Axel Mariño-Mendez, Alberto Carmona-Bayonas, Javier Gallego, A J Muñoz Martín, Paula Jimenez-Fonseca, Luis Cabezon-Gutierrez
The prognostic value of the Systemic Inflammation Response Index (SIRI) in advanced pancreatic cancer is recognized, but its correlation with patients´ nutritional status and outcomes remains unexplored.
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Does enhanced recovery after surgery programs improve clinical outcomes in liver cancer surgery? World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Belinda Sánchez-Pérez, José M Ramia
Enhanced recovery after surgery (ERAS) programs have been widely applied in liver surgery since the publication of the first ERAS guidelines in 2016 and the new recommendations in 2022. Liver surgery is usually performed in oncological patients (liver metastasis, hepatocellular carcinoma, cholangiocarcinoma, etc.), but the real impact of liver surgery ERAS programs in oncological outcomes is not clearly
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Cardiotoxicity induced by fluoropyrimidine drugs in the treatment of gastrointestinal tumors. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Mo-Wei Kong, Feng-Di Sun, Zhen-Ying Pei, Li Xu, Ze-Bi Wang, Yan Chen, Shu-Qing Tang, Ting-Fang Yang, Guo-Xiang He
In this editorial, we review the article published in World J Gastrointest Oncol 2019, 11: 1031-1042. We specifically focus on the occurrence, clinical characteristics, and risk factors of fluoropyrimidine drug-related cardiotoxicity in patients with gastrointestinal tumors. Despite significant advancements in diagnostic and therapeutic techniques that have reduced mortality rates associated with digestive
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Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 You-Wang Lu, Zhao-Li Ding, Rui Mao, Gui-Gang Zhao, Yu-Qi He, Xiao-Lu Li, Jiang Liu
Aberrant methylation is common during the initiation and progression of colorectal cancer (CRC), and detecting these changes that occur during early adenoma (ADE) formation and CRC progression has clinical value.
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Immune-related long noncoding RNA zinc finger protein 710-AS1-201 promotes the metastasis and invasion of gastric cancer cells. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Wei Ding, Wei-Wei Chen, Yi-Qin Wang, Xue-Zhong Xu, Yi-Bo Wang, Yong-Min Yan, Yu-Lin Tan
Gastric cancer (GC) is a prevalent malignant tumor of the gastrointestinal system. ZNF710 is a transcription factor (TF), and zinc finger protein 710 (ZNF710)-AS1-201 is an immune-related long noncoding RNA (lncRNA) that is upregulated in GC cells.
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Early adenocarcinoma mixed with a neuroendocrine carcinoma component arising in the gastroesophageal junction: A case report. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Yu-Qing Cheng, Geng-Fang Wang, Xiao-Li Zhou, Min Lin, Xin-Wen Zhang, Qin Huang
Early adenocarcinoma mixed with a neuroendocrine carcinoma (NEC) component arising in the gastroesophageal junctional (GEJ) region is rare and even rarer in young patients. Here, we report such a case in a 29-year-old Chinese man.
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Multifaceted role of microRNAs in gastric cancer stem cells: Mechanisms and potential biomarkers. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Qian-Hui Sun, Zi-Yu Kuang, Guang-Hui Zhu, Bao-Yi Ni, Jie Li
MicroRNAs (miRNAs) have received much attention in the past decade as potential key epigenomic regulators of tumors and cancer stem cells (CSCs). The abnormal expression of miRNAs is responsible for different phenotypes of gastric cancer stem cells (GCSCs). Some specific miRNAs could be used as promising biomarkers and therapeutic targets for the identification of GCSCs. This review summarizes the
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Prohibitin 1 inhibits cell proliferation and induces apoptosis via the p53-mediated mitochondrial pathway in vitro. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Juan-Juan Shi, Yi-Kai Wang, Mu-Qi Wang, Jiang Deng, Ning Gao, Mei Li, Ya-Ping Li, Xin Zhang, Xiao-Li Jia, Xiong-Tao Liu, Shuang-Suo Dang, Wen-Jun Wang
Prohibitin 1 (PHB1) has been identified as an antiproliferative protein that is highly conserved and ubiquitously expressed, and it participates in a variety of essential cellular functions, including apoptosis, cell cycle regulation, proliferation, and survival. Emerging evidence indicates that PHB1 may play an important role in the progression of hepatocellular carcinoma (HCC). However, the role
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Comprehensive analysis of the protein phosphatase 2A regulatory subunit B56ε in pan-cancer and its role and mechanism in hepatocellular carcinoma. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Hong-Mei Wu, Yuan-Yuan Huang, Yu-Qiu Xu, Wei-Lai Xiang, Chang Yang, Ru-Yuan Liu, Di Li, Xue-Feng Guo, Zheng-Bao Zhang, Chun-Hua Bei, Sheng-Kui Tan, Xiao-Nian Zhu
B56ε is a regulatory subunit of the serine/threonine protein phosphatase 2A, which is abnormally expressed in tumors and regulates various tumor cell functions. At present, the application of B56ε in pan-cancer lacks a comprehensive analysis, and its role and mechanism in hepatocellular carcinoma (HCC) are still unclear.
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Prognostic value of circulating tumor cells combined with neutrophil-lymphocyte ratio in patients with hepatocellular carcinoma. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Jia-Li Chen, Lu Guo, Zhen-Ying Wu, Kun He, Han Li, Chi Yang, Yun-Wei Han
Circulating tumor cell (CTC) count and neutrophil-to-lymphocyte ratio (NLR) are both closely associated with the prognosis of hepatocellular carcinoma (HCC).
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Anti-EGFR antibody monotherapy for colorectal cancer with severe hyperbilirubinemia: A case report. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Toshiaki Tsurui, Yuya Hirasawa, Yutaro Kubota, Kiyoshi Yoshimura, Takuya Tsunoda
Hyperbilirubinemia with hepatic metastases is a common complication and a poor prognostic factor for colorectal cancer (CRC). Effective drainage is often impossible before initiating systemic chemotherapy, owing to the liver's diffuse metastatic involvement. Moreover, an appropriate chemotherapeutic approach for the treatment of hyperbilirubinemia is currently unavailable.
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Progress in the treatment of advanced hepatocellular carcinoma with immune combination therapy. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Di Pan, Hao-Nan Liu, Peng-Fei Qu, Xiao Ma, Lu-Yao Ma, Xiao-Xiao Chen, Yu-Qin Wang, Xiao-Bing Qin, Zheng-Xiang Han
Advanced hepatocellular carcinoma (HCC) is a severe malignancy that poses a serious threat to human health. Owing to challenges in early diagnosis, most patients lose the opportunity for radical treatment when diagnosed. Nonetheless, recent advancements in cancer immunotherapy provide new directions for the treatment of HCC. For instance, monoclonal antibodies against immune checkpoint inhibitors (ICIs)
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Expression of cyclin-dependent kinase 9 is positively correlated with the autophagy level in colon cancer. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Lei Zheng, Jia Lu, Da-Lu Kong
Cyclin-dependent kinase 9 (CDK9) expression and autophagy in colorectal cancer (CRC) tissues has not been widely studied. CDK9, a key regulator of transcription, may influence the occurrence and progression of CRC. The expression of autophagy-related genes BECN1 and drug resistance factor ABCG2 may also play a role in CRC. Under normal physiological conditions, autophagy can inhibit tumorigenesis,
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Global research trends and prospects of cellular metabolism in colorectal cancer. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-3-1 Yan-Chen Liu, Zhi-Cheng Gong, Chao-Qun Li, Peng Teng, Yan-Yan Chen, Zhao-Hui Huang
An increasing number of studies have focused on the role of cellular metabolism in the development of colorectal cancer (CRC). However, no work is currently available to synthesize the field through bibliometrics.
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Prognostic significance and relationship of SMAD3 phospho-isoforms and VEGFR-1 in gastric cancer: A clinicopathological study. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 Shi-Lin Lv, Pei Guo, Jun-Rong Zou, Ren-Sheng Chen, Ling-Yu Luo, De-Qiang Huang
The TGF-β/SMAD3 and VEGFR-1 signaling pathways play important roles in gastric cancer metastasis. SMAD3 phosphorylation is a crucial prognostic marker in gastric cancer.
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Present situation and prospect of immunotherapy for unresectable locally advanced esophageal cancer during peri-radiotherapy. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 Feng-Mei Wang, Peng Mo, Xue Yan, Xin-Yue Lin, Zhi-Chao Fu
Four major studies (Checkmate577, Keynote-590, Checkmate649 and Attraction-4) of locally advanced esophageal cancer published in 2020 have established the importance of immunotherapy, represented by anti-programmed death protein (PD)-1 in postoperative adjuvant treatment and advanced first-line treatment of locally advanced or advanced esophageal cancer and esophagogastric junction cancer, from the
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Trends in colorectal cancer incidence according to an increase in the number of colonoscopy cases in Korea. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 Ga Hee Kim, Yeong Chan Lee, Tae Jun Kim, Sung Noh Hong, Dong Kyung Chang, Young-Ho Kim, Dong-Hoon Yang, Chang Mo Moon, Kyunga Kim, Hyun Gun Kim, Eun-Ran Kim
The incidence of colorectal cancer (CRC) and preinvasive CRC (e.g., early colon cancer and advanced adenoma) is gradually increasing in several countries.
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Analysis of the potential biological value of pyruvate dehydrogenase E1 subunit β in human cancer. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 Yao Rong, Song-Hua Liu, Ming-Zheng Tang, Zhi-Hang Wu, Guo-Rong Ma, Xiao-Feng Li, Hui Cai
The pyruvate dehydrogenase E1 subunit β (PDHB) gene which regulates energy metabolism is located in mitochondria. However, few studies have elucidated the role and mechanism of PDHB in different cancers.
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Clinical value of oral contrast-enhanced ultrasonography in diagnosis of gastric tumors. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 Chuan-Yu Wang, Xiao-Jing Fan, Fei-Liang Wang, Yue-Yue Ge, Zhao Cai, Wei Wang, Xin-Ping Zhou, Jun Du, De-Wei Dai
The incidence of gastric cancer remains high, and it is the sixth most common cancer and the fourth leading cause of cancer deaths worldwide. Oral contrast-enhanced ultrasonography is a simple, non-invasive, and painless method for the diagnosis of gastric tumors.
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Comparative study between Embosphere® and Marine gel® as embolic agents for chemoembolization of hepatocellular carcinoma. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 Hyo-Cheol Kim, Jin Woo Choi
While gelatin sponge particles and calibrated microspheres are commonly used as embolic materials in conventional transarterial chemoembolization (cTACE), direct comparisons between these embolic agents are rare.
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New trends in diagnosis and management of gallbladder carcinoma. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 Efstathios T Pavlidis, Ioannis N Galanis, Theodoros E Pavlidis
Gallbladder (GB) carcinoma, although relatively rare, is the most common biliary tree cholangiocarcinoma with aggressiveness and poor prognosis. It is closely associated with cholelithiasis and long-standing large (> 3 cm) gallstones in up to 90% of cases. The other main predisposing factors for GB carcinoma include molecular factors such as mutated genes, GB wall calcification (porcelain) or mainly
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Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer: A systematic review. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 Eman Al-Balushi, Amina Al Marzouqi, Shima Tavoosi, Amir Hossein Baghsheikhi, Arash Sadri, Leyla Sharifi Aliabadi, Mohammad-Mahdi Salarabedi, Syed Azizur Rahman, Nabeel Al-Yateem, Alireza Mosavi Jarrahi, Aram Halimi, Mohammad Ahmadvand, Wael M Abdel-Rahman
Colorectal cancer (CRC) is the third most frequent and the second most fatal cancer. The search for more effective drugs to treat this disease is ongoing. A better understanding of the mechanisms of CRC development and progression may reveal new therapeutic strategies. Ubiquitin-specific peptidases (USPs), the largest group of the deubiquitinase protein family, have long been implicated in various
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Development and validation of a machine learning-based early prediction model for massive intraoperative bleeding in patients with primary hepatic malignancies. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 Jin Li, Yu-Ming Jia, Zhi-Lei Zhang, Cheng-Yu Liu, Zhan-Wu Jiang, Zhi-Wei Hao, Li Peng
Surgical resection remains the primary treatment for hepatic malignancies, and intraoperative bleeding is associated with a significantly increased risk of death. Therefore, accurate prediction of intraoperative bleeding risk in patients with hepatic malignancies is essential to preventing bleeding in advance and providing safer and more effective treatment.
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Application of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy in curative surgery for esophageal cancer: A meta-analysis. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 Mao-Xiu Yuan, Qi-Gui Cai, Zhen-Yang Zhang, Jian-Zhong Zhou, Cai-Yun Lan, Jiang-Bo Lin
The effectiveness of neoadjuvant therapy in esophageal cancer (EC) treatment is still a subject of debate.
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C-reactive protein to albumin ratio predict responses to programmed cell death-1 inhibitors in hepatocellular carcinoma patients. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 Bai-Bei Li, Lei-Jie Chen, Shi-Liu Lu, Biao Lei, Gui-Lin Yu, Shui-Ping Yu
Over the years, programmed cell death-1 (PD-1) inhibitors have been routinely used for hepatocellular carcinoma (HCC) treatment and yielded improved survival outcomes. Nonetheless, significant heterogeneity surrounds the outcomes of most studies. Therefore, it is critical to search for biomarkers that predict the efficacy of PD-1 inhibitors in patients with HCC.
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Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer: A case report. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 João Gramaça, Isabel Gomes Fernandes, Carolina Trabulo, Joana Gonçalves, Rita Gameiro Dos Santos, Adriano Baptista, Idília Pina
In patients with metastatic colorectal cancer (mCRC), the treatment options are limited and have been proved to be affected by rat sarcoma virus (RAS) mutational status. In RAS wild-type (wt) patients, the combination of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies with chemotherapy (CT) is more effective than CT alone. On the other hand, RAS-mutated patients are not eligible
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Early gastric cancer recurrence after endoscopic submucosal dissection: Not to be ignored! World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 Yan Zeng, Jian Yang, Jun-Wen Zhang
This editorial comments on the article "Efficacy of multi-slice spiral computed tomography in evaluating gastric cancer recurrence after endoscopic submucosal dissection". We focus on the importance of paying more attention to post-endoscopic submucosal dissection (ESD) gastric cancer recurrence in patients with early gastric cancer (EGC) and how to manage it effectively. ESD has been a well-known
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Colorectal cancer's burden attributable to a diet high in processed meat in the Belt and Road Initiative countries. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 Gu Liu, Chang-Min Li, Fei Xie, Qi-Lai Li, Liang-Yan Liao, Wen-Jun Jiang, Xiao-Pan Li, Guan-Ming Lu
Colorectal cancer (CRC) plays a significant role in morbidity, mortality, and economic cost in the Belt and Road Initiative ("B and R") countries. In addition, these countries have a substantial consumption of processed meat. However, the burden and trend of CRC in relation to the consumption of a diet high in processed meat (DHPM-CRC) in these "B and R" countries remain unknown.
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Comprehensive evaluation of rare case: From diagnosis to treatment of a sigmoid Schwannoma: A case report. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 Jing-Yi Li, Xi-Zhuang Gao, Jian Zhang, Xiang-Zheng Meng, Yi-Xian Cao, Kun Zhao
Schwannomas are uncommon tumors originating from Schwann cells, forming the neural sheath. They account for approximately 2%-6% of all mesenchymal tumors and are most commonly identified in peripheral nerve trunks, with rarity in the gastrointestinal tract. Among gastrointestinal locations, the stomach harbors the majority of nerve sheath tumors, while such occurrences in the sigmoid colon are exceptionally
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Colonoscopy plays an important role in detecting colorectal neoplasms in patients with gastric neoplasms. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 Xu-Rui Liu, Ze-Lin Wen, Fei Liu, Zi-Wei Li, Xiao-Yu Liu, Wei Zhang, Dong Peng
Gastric cancer (GC) and colorectal cancer (CRC) are the fifth and third most common cancer worldwide, respectively. Nowadays, GC is reported to have a potential predictive value for CRC, especially for advanced CRC.
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Impact of propofol and sevoflurane anesthesia on cognition and emotion in gastric cancer patients undergoing radical resection. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 Ao-Han Li, Su Bu, Ling Wang, Ai-Min Liang, Hui-Yu Luo
Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric cancer. However, there is a debate concerning their differential effects on cognitive function, anxiety, and depression in patients undergoing this procedure.
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Mechanism of pachymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-31 Yu-Hua Du, Jian-Jun Zhao, Xia Li, Shi-Cong Huang, Na Ning, Guo-Qing Chen, Yi Yang, Yi Nan, Ling Yuan
Pachymic acid (PA) is derived from Poria cocos. PA has a variety of pharmacological and inhibitory effects on various tumors. However, the mechanism of action of PA in gastric cancer (GC) remains unclear.
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Hsa_circ_0136666 mediates the antitumor effect of curcumin in colorectal carcinoma by regulating CXCL1 via miR-1301-3p. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-4 Shi Chen, Wei Li, Chen-Gong Ning, Feng Wang, Li-Xing Wang, Chen Liao, Feng Sun
This study investigate the anti-tumor effect of curcumin and whether its mediated by hsa_circ_0136666 through miR-1301-3p/CXCL1 in colorectal carcinoma (CRC). Through multiple experiments, we have drawn the conclusion that curcumin inhibited CRC development through the hsa_circ_0136666/miR-1301-3p/CXCL1 axis, hinting at a novel treatment option for curcumin to prevent CRC development.
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Application of remimazolam transversus abdominis plane block in gastrointestinal tumor surgery. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-4 Jun Liu, Jian-Min Tian, Guo-Ze Liu, Jun-Na Sun, Peng-Fei Gao, Yong-Qiang Zhang, Xiu-Qin Yue
Transversus abdominis plane block (TAPB) is a block of the abdominal afferent nerve fibers between the internal oblique muscle and the transverse abdominal muscle achieved with local anesthetics. It can effectively block the conduction of the anterior nerve of the abdominal wall and exert a good analgesic effect. However, the effect of combining the block with remimazolam on anesthesia in patients
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Identification of genes associated with gall bladder cell carcinogenesis: Implications in targeted therapy of gall bladder cancer. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-4 Ishita Ghosh, Ruma Dey Ghosh, Soma Mukhopadhyay
Gall bladder cancer (GBC) is becoming a very devastating form of hepatobiliary cancer in India. Every year new cases of GBC are quite high in India. Despite recent advanced multimodality treatment options, the survival of GBC patients is very low. If the disease is diagnosed at the advanced stage (with local nodal metastasis or distant metastasis) or surgical resection is inoperable, the prognosis
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The efficacy of full-thickness endoscopic resection of subepithelial tumors in the gastric cardia. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-4 En-Pan Xu, Zhi-Peng Qi, Bing Li, Zhong Ren, Ming-Yan Cai, Shi-Lun Cai, Zhen-Tao Lyv, Zhang-Han Chen, Jing-Yi Liu, Qiang Shi, Yun-Shi Zhong
Gastric subepithelial tumors (SETs) may harbor potential malignancy. Although it is well recognized that large SETs should be resected, the precise treatment strategy remains controversial. Compared to surgical resection, endoscopic resection (ER) has many advantages; however, ER of SETs in the cardia is challenging.
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Paired-related homeobox 1 induces epithelial-mesenchymal transition in oesophageal squamous cancer. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-4 Jin-Bao Guo, Ming Du, Bin Wang, Li Zhong, Zhong-Xue Fu, Jin-Lai Wei
It is unclear that paired-related homeobox 1 (PRRX1) induces epithelial-mesenchymal transition (EMT) in oesophageal cancer and the specific function of PRRX1 in oesophageal cancer metastasis.
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Association of MBOAT7 rs641738 polymorphism with hepatocellular carcinoma susceptibility: A systematic review and meta-analysis. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-4 Min Lai, Ya-Lu Qin, Qiong-Yu Jin, Wen-Jing Chen, Jia Hu
The MBOAT7 rs641738 single-nucleotide polymorphism (SNP) has been proven to influence various liver diseases, but its association with hepatocellular carcinoma (HCC) susceptibility has been debated. To address this discrepancy, we conducted the current systematic review and meta-analysis.
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Intensive follow-up vs conventional follow-up for patients with non-metastatic colorectal cancer treated with curative intent: A meta-analysis. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-4 Li-Li Cui, Shi-Qi Cui, Zhong Qu, Zhen-Qing Ren
The frequency and content of follow-up strategies remain controversial for colorectal cancer (CRC), and scheduled follow-ups have limited value.
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Dual primary gastric and colorectal cancer: A complex challenge in surgical oncology. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-4 Luigi Marano
The intricate interplay of colorectal cancer (CRC) and gastric cancer (GC) as dual primary malignancies presents a significant challenge in surgical oncology. CRC is the most common secondary malignancy in GC patients, and vice versa, evidence highlighted by advances in diagnostic procedures and therapy modalities that impact patient survival. A recent study titled "Features of synchronous and metachronous
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Evaluating the causal relationship between human blood metabolites and gastroesophageal reflux disease. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-4 Jia-Yan Hu, Mi Lv, Kun-Li Zhang, Xi-Yun Qiao, Yu-Xi Wang, Feng-Yun Wang
Gastroesophageal reflux disease (GERD) affects approximately 13% of the global population. However, the pathogenesis of GERD has not been fully elucidated. The development of metabolomics as a branch of systems biology in recent years has opened up new avenues for the investigation of disease processes. As a powerful statistical tool, Mendelian randomization (MR) is widely used to explore the causal
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Conversion immunotherapy for deficient mismatch repair locally unresectable colon cancer: A case report. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-4 Zhen Sun, He Liu, Guan-Nan Zhang, Yi Xiao
Owing to the special features of biologics, deficient mismatch repair (dMMR) in patients with colon cancer has achieved little treatment efficacy from chemoradiotherapy. Immunotherapy has shown promising results for the treatment of colon cancer. The high response rate observed suggests a great option for patients presenting with unresectable tumors, as it allows for better oncological resection. Here
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Effect of ultrasound-guided lumbar square muscle block on stress response in patients undergoing radical gastric cancer surgery. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-4 Xin-Ran Wang, Dan-Dan Xu, Meng-Jiao Guo, Yi-Xin Wang, Meng Zhang, Dong-Xiao Zhu
Radical surgery is a common treatment for patients with gastric cancer; however, it can lead to postoperative complications and intestinal barrier dysfunction. Ultrasound-guided quadratus lumborum block is often used for postoperative analgesia, but its effects on stress response and intestinal barrier function are not well understood.
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Cohort study to assess geographical variation in cholangiocarcinoma treatment in England. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-4 Sophie Jose, Amy Zalin-Miller, Craig Knott, Lizz Paley, Daniela Tataru, Helen Morement, Mireille B Toledano, Shahid A Khan
Outcomes for cholangiocarcinoma (CCA) are extremely poor owing to the complexities in diagnosing and managing a rare disease with heterogenous sub-types. Beyond curative surgery, which is only an option for a minority of patients diagnosed at an early stage, few systemic therapy options are currently recommended to relieve symptoms and prolong life. Stent insertion to manage disease complications requires
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Association between heat shock factor protein 4 methylation and colorectal cancer risk and potential molecular mechanisms: A bioinformatics study. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-4 Wen-Jing Zhang, Ke-Lin Yue, Jing-Zhai Wang, Yu Zhang
We previously demonstrated that heat shock factor protein 4 (HSF4) facilitates colorectal cancer (CRC) progression. DNA methylation, a major modifier of gene expression and stability, is involved in CRC development and outcome.
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Transient receptor potential-related risk model predicts prognosis of hepatocellular carcinoma patients. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-4 Xiao-Cai Mei, Qian Chen, Shi Zuo
Members of the transient receptor potential (TRP) protein family shape oncogenic development, but the specific relevance of TRP-related genes in hepatocellular carcinoma (HCC) has yet to be defined.
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Prognostic value of T cell immunoglobulin and mucin-domain containing-3 expression in upper gastrointestinal tract tumors: A meta-analysis. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-4 Jing-Jing Yan, Bing-Bing Liu, Yan Yang, Meng-Ru Liu, Han Wang, Zhen-Quan Deng, Zhi-Wei Zhang
There is a lack of robust prognostic markers for upper gastrointestinal (GI) tract cancers, including esophageal, gastric, and esophagogastric junction cancers. T cell immunoglobulin and mucin-domain containing-3 (TIM3) plays a key immunomodulatory role and is linked to the prognosis of various cancers. However, the significance of TIM3 in upper GI tract tumors is still uncertain.
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Combined TIM-3 and PD-1 blockade restrains hepatocellular carcinoma development by facilitating CD4+ and CD8+ T cell-mediated antitumor immune responses. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2024-1-4 Xu-Sheng Zhang, Hong-Cai Zhou, Peng Wei, Long Chen, Wei-Hu Ma, Lin Ding, Shi-Cai Liang, Ben-Dong Chen
Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1) and T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) are beneficial to the resumption of anti-tumor immunity response and hold extreme potential as efficient therapies for certain malignancies. However, ICIs with a single target exhibit poor overall response rate in hepatocellular carcinoma (HCC)
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Association between the Khorana risk score and all-cause mortality in Japanese patients with gastric and colorectal cancer: A retrospective cohort study. World J. Gastrointest. Oncol. (IF 3.0) Pub Date : 2023-10-15 Yu-Feng Zhang,Guo-Dong Wang,Min-Guang Huang,Zhao-Qi Qiu,Jia Si,Mao-Yi Xu
BACKGROUND The Khorana risk score (KRS) has poor predictive value for cancer-associated thrombosis in a single tumor type but is associated with early all-cause mortality from cancer. Evidence for the association between KRS and all-cause mortality in Japanese patients with gastric and colorectal cancer is limited. AIM To investigate whether KRS was independently related to all-cause mortality in Japanese