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Multichannel intraesophageal impedance with pH metry in Saudi children. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-11-24 Mohammad El Mouzan,Ahlam Al Naqeeb,Najla Al Otaibi,Jawaher Al Askar,Teema Joseph,Ahmed Al Sarkhy,Mona Al Asmi,Asaad Assiri
BACKGROUND Multichannel Intraesophageal Impedance with pH (MII-pH) provides complete characterization of gastroesophageal reflux (GER). The aim of this study was to report our experience in this relatively new technique, emphasizing the challenges in the performance and interpretation of the results. METHODS The study was conducted at King Khalid University Hospital at King Saud University in Riyadh
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Endohepatology: The endoscopic armamentarium in the hand of the hepatologist. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-11-18 Ahmed Alwassief,Said Al-Busafi,Qasim L Abbas,Khalid Al Shamusi,Sarto C Paquin,Anand V Sahai
Recent advances in the field of hepatology include new and effective treatments for viral hepatitis. Further effort is now being directed to other disease entities, such as non-alcoholic fatty liver disease, with an increased need for assessment of liver function and histology. In fact, with the evolving nomenclature of fat-associated liver disease and the emergence of the term "metabolic-associated
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Value of preoperative biliary drainage in pancreatic head cancer patients with severe obstructive jaundice: A multicenter retrospective study. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-11-18 Bin Lu,Yao Chen,Songyuan Qin,Jiansheng Chen
BACKGROUND Pancreatic head cancer accompanied by obstructive jaundice is a common clinical situation. The aim of this study was to assess the impact of preoperative biliary drainage (PBD) on clinical outcomes in patients with severe obstructive jaundice. METHODS Patients with a bilirubin level of ≥250 mmol/L at diagnosis who underwent PBD were included. The primary endpoints and secondary endpoints
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Using noninvasive clinical parameters to predict mortality and morbidity after cardiac interventions in patients with cirrhosis: A systematic review. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-11-18 Christo Mathew,Ankur Patel,George Cholankeril,Avegail Flores,Ruben Hernaez
BACKGROUND Cardiovascular disease commonly affects advanced liver disease patients. They undergo cardiac interventions to improve cardiac outcomes. Cirrhosis increases complication risk, including bleeding, renal and respiratory failure, and further decompensation, including death, posing a clinical dilemma to proceduralists. Predicting outcomes is crucial in managing patients with cirrhosis. Our aim
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Is IBD disk a reliable tool in Saudi Arabia? Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-11-08 Zahra A Al Saeed,Turki AlAmeel
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Real-life experiences and barriers to adjuvant chemotherapy in Saudi patients with advanced stage II and stage III colon cancer. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-11-07 Mesnad S Alyabsi,Anwar H Alqarni,Adel F Almutairi,Nahar A Alselaim,Mohammed A Algarni,Kanan M Alshammari
BACKGROUND Colorectal cancer is the most common malignancy in Saudi males and third most common in females. Patients with locally advanced colon cancer may eventually develop metastatic disease if not treated promptly and according to guidelines. The recent National Comprehensive Cancer Network guideline recommends tumor resection followed by adjuvant chemotherapy for stage III and high-risk stage
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Analysis of the risk of future gastrointestinal surgery in Crohn's disease with stricture. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-10-25 Wen Zeng,Yong Chen,Bolong Yin,Xue Wen,Jian Xiao,Lian Luo,Haiyuan Tang,He Zheng
BACKGROUND Stricture in patients with Crohn's disease (CD) carries a high risk of CD-related surgery in the course of the disease. The aim of this study was to assess the rate of occurrence of CD-related surgery and to determine baseline risk factors predicting subsequent surgery in this patient group. METHODS Patients registered with stricturing CD were included. All baseline and follow-up data were
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Gray zone of hepatitis B virus infection. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-10-09 Young-Suk Lim
A substantial proportion of patients with chronic hepatitis B (CHB) do not fall into any of the defined phases and are considered to be in the "gray zone" or "indeterminate phase." Most of the current clinical practice guidelines have no recommendations for antiviral treatment for them. However, the gray zone CHB patients with significant hepatitis B virus levels (>2000 IU/mL) and persistently normal
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Efficacy of early biologic therapy versus late/conventional therapy in children and adolescents with Crohn's disease: A systematic review and meta-analysis. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-09-15 Lei Zhang,Zhixiao Jin,Jia Hao
Background The objective of this study was to estimate the effectiveness of early biologics compared to conventional treatment in the management of Crohn's disease among pediatric and adolescent patients. Methods A comprehensive literature search was conducted in four electronic databases to identify relevant studies published from inception to 2023. The inclusion criteria comprised randomized controlled
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Construction of an enteral nutrition evaluation system for critically ill patients based on the Delphi method. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-09-15 Yanrong Yao,Jingli Liu,Hongmei Xue,Xiaoyan Wang,Weijie Yao,Na Liu,Zuozheng Wang,Guangli Mi
Background This study aimed to construct an enteral nutrition evaluation system for critically ill patients using the Delphi method to direct the formulation of enteral nutrition support strategies and reduce interruption to enteral feeding. Methods We used domestic and foreign databases to obtain and analyze the literature and form "The Whole-Proceeding Enteral Nutrition Evaluation System for Critically
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Artificial intelligence in endoscopy: Overview, applications, and future directions. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-09-06 Arif A Arif,Shirley X Jiang,Michael F Byrne
Since the emergence of artificial intelligence (AI) in medicine, endoscopy applications in gastroenterology have been at the forefront of innovations. The ever-increasing number of studies necessitates the need to organize and classify applications in a useful way. Separating AI capabilities by computer aided detection (CADe), diagnosis (CADx), and quality assessment (CADq) allows for a systematic
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Clinical and laboratory features of biliary atresia and patterns of management practices: Saudi national study (2000-2018). Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-09-06 Homoud Alhebbi,Mohammed El-Edreesi,Mohammed Abanemai,Omar Saadah,Maher Alhatlani,Hana Halabi,Razan Bader,Ahmed Al Sarkhy,Ahmed Aladsani,Sami Wali,Talal Alguofi,Nawaf Alkhathran,Amira NasserAllah,Muhammed Salman Bashir,Abdulrahman Al-Hussaini
Background We utilized the data from the Saudi national biliary atresia (BA) study (2000-2018) to describe the clinical, biochemical, imaging, and histopathological features of BA and the perioperative clinical practices among local pediatric gastroenterologists. Methods This is a retrospective, multicenter, nationwide study that included 10 tertiary care governmental hospitals including the four liver
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The when, why and whom to biopsy of type 1 diabetes mellitus children with positive anti-tissue transglutaminase serology. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-08-09 Stefano Guandalini
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Association of esophageal motility disorder symptoms with Chicago classification versions 3.0 and 4.0 using high-resolution esophageal manometry: A single-center experience from Saudi Arabia. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-08-08 Mohammed A Alzahrani,Mohammed A Alfahadi,Meshref A Alshehri,Abdulaziz H Alamri,Eman A Almahjani,Aishah M Alahmari,Abdullah A Al-Shahrani,Abdulaziz S Alshahrani,Ibrahim M Almanjahi,Abdullah M Alqarni
Background Esophageal motility disorders (EMDs) can significantly impact patients' quality of life. The Chicago Classification (CC) was developed as a robust framework to enable clinicians to better understand and classify the nature of motility disorders. Previous studies have primarily focused on the CC version 3.0 (CCv3.0), and data regarding the correlation between symptoms and CC version 4.0 (CCv4
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An algorithm-based active cleansing protocol can reduce the bowel preparation time for screening colonoscopy: A propensity score matching study. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-07-19 Fumiaki Ishibashi,Sho Suzuki,Ryu Tanaka,Konomi Kobayashi,Tomohiro Kawakami,Mizuki Nagai,Kentaro Mochida,Tetsuo Morishita
Background Methods that minimize the time for on-site bowel preparation before colonoscopy are needed. We prospectively validated that a novel algorithm-based active cleansing (ABAC) protocol could reduce the time for preparation compared with the conventional method. Methods This was an open-label, multicenter, prospective comparative study from April to October 2021. The study compared the bowel
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Clinical and pathological characteristics of early-onset colorectal cancer in South Korea. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Su Bee Park,Jin Young Yoon,Min Seob Kwak,Jae Myung Cha
Background Early-onset colorectal cancer (EOCRC) may differ by race and ethnicity, and recently South Korea has witnessed a surge in cases. We aimed to evaluate the clinical and pathological features of patients with EOCRC, and to determine the predictors of overall survival. Methods In this retrospective study, EOCRC was defined as CRC diagnosed in patients aged < 50 years, and late-onset CRC was
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Association between smoking and colorectal cancer in Eastern Mediterranean Regional Office (EMRO): A systematic review and meta-analysis. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Mohammad-Hossein Keivanlou,Ehsan Amini-Salehi,Soheil Hassanipour,Abinash Mahapatro,Nakka Raghuma,Farahnaz Joukar,Negin Letafatkar,Arman Habibi,Naeim Norouzi,Maryam Sadat Aleali,Mona Javid,Arian Mirdamadi,Fariborz Mansour-Ghanaei
Background Smoking poses a significant risk for colorectal cancer (CRC), considered the third leading reason for cancer-related deaths worldwide. However, there has been limited research on the relationship between smoking and CRC in the Eastern Mediterranean Regional Office (EMRO). Therefore, a meta-analysis was conducted to combine available data and gain a comprehensive understanding of the relationship
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Long-term health and economic benefits of switching to tenofovir alafenamide versus continuing on entecavir in chronic hepatitis B patients with low-level viremia in Saudi Arabia. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-06-30 Faisal M Sanai,Mohammed Aljawad,Abdullah Saeed Alghamdi,Alon Yehoshua,Abdullah Khathlan,Mohammed Alghamdi,Sam Kozma,Nathaniel Smith,Fadoua El-Moustaid,Sushanth Jeyakumar,Nandita Kachru
Background Despite the success of current treatments, many chronic hepatitis B (CHB) patients still live with low-level viremia [LLV] resulting in liver disease progression. This study evaluated the long-term health and economic impact of switching to tenofovir alafenamide (TAF) from entecavir (ETV) in Saudi Arabia (SA) in chronic hepatitis B (CHB) LLV patients. Methods A hybrid decision tree Markov
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Does percutaneous cholecystostomy affect prognosis of patients with acute cholecystitis that are unresponsive to conservative treatment? Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Danny Hazan,Eyal Leibovitz,Muhamad Jazmawi,Mordechai Shimonov
Background Percutaneous cholecystostomy (PC) can be used as bridging or definitive therapy in some cases of acute cholecystitis. We aimed to compare hospital stay and survival of patients that underwent PC insertion because of acute calculus cholecystitis (ACC) compared to those who did not. Methods This is a retrospective study in which patients with gangrenous cholecystitis and perforation were excluded
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Effects of irritable bowel syndrome on the health-related quality of life among the Saudi population. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-06-22 Emad S Aljahdli,Ftoon Badroun,Hanan H Mushaeb,Raghad Aljohani,Sara Albisher,Leena Basalaim,Salma Baeisa
Background Irritable bowel syndrome (IBS) is a digestive system disorder. Patients with IBS have a significantly lower quality of life (QoL). In this study, we aimed to assess how IBS affects the Saudi Arabian population's health-related (HR)-QoL. Methods A cross-sectional Web-based survey was conducted with a representative sample (n = 1346) of patients who met the Rome IV criteria for IBS from all
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Clinicopathological and prognostic features of Borrmann type IV gastric cancer versus other Borrmann types: A unique role of signet ring cell carcinoma. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Chengcai Liang,Yao Liang,Biyi Ou,Lei Yuan,Shuqiang Yuan
Background Evidence specifically comparing the clinicopathology of Borrmann type IV (B-IV) gastric cancer with that of other Borrmann types is insufficient. Methods A total of 3130 patients with advanced gastric cancer who underwent gastrectomy from January 2001 to September 2017 were enrolled in the analysis. Logistic regression and survival analysis methodology were used to investigate factors associated
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IBD in the elderly - beware of pitfalls! Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Mohmmed T Sharip,Sreedhar Subramanian
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IBD-Disk as a tool estimating the prevalence of inflammatory bowel disease-related disability and associated influencing factors in Saudi Arabia: A cross-sectional study. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-06-08 Yaser Meeralam,Adnan B Al-Zanbagi,Mona Al Saedi,Walaa Alharthi,Hanadi A Sabbahi,Talal Alhejaili,Mohammed K Shariff
Background Inflammatory bowel disease (IBD) disk is an easy tool to use in clinical practice to measure IBD-related disability, with a score >40 correlating with high daily-life burden. Its use has been limited mainly to the western world. We aimed to estimate the prevalence of IBD-related disability and evaluate the associated risk factors in Saudi Arabia. Methods In this cross sectional study conducted
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The prevalence and clinical characteristics of Clostridium difficile infection in Saudi patients admitted with inflammatory bowel disease: A case-control study. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Abdulrahman AlKhormi,Abdullah M Altheyabi,Saud A AlGhamdi,Osama Alshahrani,Abdulwahed A Alotay,Ahmad Deeb
Background Inflammatory bowel disease (IBD) patients are at increased risk of Clostridium difficile infection (CDI), causing significant morbidity and mortality. This study examined CDI's prevalence, predisposing factors, and clinical outcomes in Saudi hospitalized IBD patients. Methods : A retrospective case-control study was conducted at a tertiary medical city in Riyadh, Saudi Arabia. All Saudi
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Frequency and predictive factors for spontaneous normalization of anti-tissue transglutaminase-IgA serology among Saudi children with type 1 diabetes mellitus: A cohort study. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Ahmed Al Sarkhy,Ali Al Hassan,Heba Assiri,Hayfa Alabdulkarim,Noor AlAnazi,Nawaf Alshammari,Najla AlOtaibi,Mona Al Asmi,Asaad Assiri,Reem Al-Khalifah,Shaik Shaffi Ahamed,Mohammad El Mouzan
Background Celiac serology can be transiently elevated in patients with type 1 diabetes mellitus (T1DM) and normalized despite gluten consumption. This study aimed to identify the frequency and predictive factors of spontaneous normalization of anti-tissue transglutaminase (anti-TTG-IgA) antibodies in these patients. Methods The charts of all patients (≤18 years) with T1DM were retrospectively reviewed
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Peroral endoscopic myotomy (POEM) for achalasia in the Middle East: The type of myotomy matters. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Bahtiyar Muhammedoğlu
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Complementary and alternative medicine use and its association with medication adherence in inflammatory bowel disease and other gastrointestinal diseases. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Abdul Hakim Almakadma,Abdelkarim De Vol,Mohamad S Alabdaljabar,Sarah Aldosari,Ibrahim Muhsen,Omar AlFreihi,Amr Kurdi,Majid Almadi,Fahad Alsohaibani
Background The use of complementary and alternative medicines (CAMs) has been embedded in populations for decades. In this study, we aimed to determine the rate of their usage among inflammatory bowel disease (IBD) patients and their association with adherence to conventional therapies. Methods In this cross sectional, survey-based study, IBD patients' (n=226) adherence and compliance were evaluated
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Technique, sedation, and clinical outcome of endoscopic submucosal dissection for rectal tumor with involvement of dentate line: A retrospective cohort study. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Yoon Kyoo Noh,Jun Lee,Seong Jung Kim
Background Endoscopic submucosal dissection (ESD) of rectal tumors involving the dentate line (RT-DL) is challenging because of the anatomical features of the anal canal. This study aimed to identify optimal techniques and sedation and to determine the clinical outcomes of ESD for RT-DL. Methods We retrospectively collected medical records and endoscopic results of patients who underwent ESD for rectal
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Performance of artificial intelligence in the characterization of colorectal lesions. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Carlos E O Dos Santos,Daniele Malaman,Ivan D Arciniegas Sanmartin,Ari B S Leão,Gabriel S Leão,Júlio C Pereira-Lima
Background Image-enhanced endoscopy (IEE) has been used in the differentiation between neoplastic and non-neoplastic colorectal lesions through microvasculature analysis. This study aimed to evaluate the computer-aided diagnosis (CADx) mode of the CAD EYE system for the optical diagnosis of colorectal lesions and compare it with the performance of an expert, in addition to evaluating the computer-aided
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CRAB score for prediction of colectomy within 2 years following admission for acute severe ulcerative colitis. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Krishnadas Devadas,Suprabhat Giri,Jijo Varghese,Antony George
Background The Oxford and Swedish indexes were developed to predict in-hospital colectomy in acute severe ulcerative colitis (ASUC), but not long-term prediction, and all these indexes were based on Western data. Our study aimed to analyze the predictors of colectomy within 3 years of ASUC in an Indian cohort and derive a simple predictive score. Methods A prospective observational study was conducted
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Oncological outcomes of elective versus emergency surgery for colon cancer: A tertiary academic center experience. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Thamer A Bin Traiki,Sulaiman A AlShammari,Razan N AlRabah,Amirah M AlZahrani,Saud T Alshenaifi,Noura S Alhassan,Maha-Hamadien Abdulla,Ahmad M Zubaidi,Omar A Al-Obeed,Khayal A Alkhayal
Background In this study, we aimed to identify the oncological outcomes in colon cancer patients who underwent elective versus emergency curative resection. Methods All patients who underwent curative resection for colon cancer between July 2015 and December 2019 were retrospectively reviewed and analyzed. Patients were divided into two groups based on the presentation into elective and emergency groups
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High-dose dual therapy versus bismuth-containing quadruple therapy for the treatment of helicobacter pylori infection: A meta-analysis of randomized controlled trials. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Chong Zhang,Jun Zhang,Yu-Jie Cheng
Background Helicobacter pylori (H. pylori) infection is one of the most important public health issues, and bismuth-containing quadruple therapy (BQT) is the first-line therapeutic option. This study aimed to compare the efficacy and safety of high-dose dual therapy (HDDT) and BQT in eradicating H. pylori. Methods Randomized controlled trials (RCTs) were retrieved from Pubmed, Embase, and Cochrane
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Predictors of biliary atresia outcome: Saudi National Study (2000 - 2018). Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-03-20 Mohammed Abanemai,Mohammed AlEdreesi,Ahmed Al Sarkhy,Omar I Saadah,Homoud Alhebbi,Razan Bader,Maher Alhatlani,Hana Halabi,Ahmed Aladsani,Sami Wali,Talal Alguofi,Fahad Alsayed,Amira NasserAllah,Ahmed Almehmadi,Afnan Qurban,Muhammed Salman Bashir,Aisha Alamri,Abdulrahman Al-Hussaini
Background Outcomes in biliary atresia (BA) have been well-documented in large national cohorts from Europe, North America, and East Asia. Understanding the challenges that preclude success of the Kasai portoenterostomy (KPE) is the key to improve the overall outcomes of BA and implementing intervention strategies. Here, we analyzed the data from the Saudi national BA study (204 BA cases diagnosed
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Doing things right and doing the right things: Colorectal cancer screening in Saudi Arabia. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Majid A Almadi,Partha Basu
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The Saudi Gastroenterology Association guidelines for quality indicators in gastrointestinal endoscopic procedures. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Fahad Alsohaibani,Hesham Aljohany,Abdul Hakim Almakadma,Ahmed Hamed,Resheed Alkhiari,Emad Aljahdli,Majid Almadi
The quality and safety of gastrointestinal endoscopy varies considerably across regions and facilities worldwide. In this field, quality management has traditionally focused on individual performance of endoscopists, with most indicators addressing process measures and limited evidence of improvement in health outcomes. Indicators of quality can be classified according to their nature and sequence
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Combining serum uric acid and fatty liver index to improve prediction quality of nonalcoholic fatty liver disease. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Yajie Ding,Zongzhe Tang,Minxian Wang,Min Wang,Ru Zhang,Liuxin Zhang,Mengting Zhang,Qing Guan,Jie Wang
Background The significant association between serum uric acid (SUA) and nonalcoholic fatty liver disease (NAFLD) is well documented. In this report, we tested the hypothesis that SUA might improve the widely studied fatty liver index (FLI) to predict NAFLD. Methods A cross-sectional study was performed in a community of Nanjing, China. The population data on sociodemographics, physical examinations
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Evaluation of intestinal ultrasound for disease activity assessment in patients with inflammatory bowel disease: A cross-sectional study at a tertiary centre in Malaysia. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Kuan Yee Lim,Raja Affendi Raja Ali,Zhiqin Wong,Faizah Mohd Zaki,Juliana Fairuz Maktar,Khairul Najmi Muhammad Nawawi
Background The use of intestinal ultrasound (IUS) in the management of inflammatory bowel disease (IBD) is emerging. We aim to determine the performance of IUS in the assessment of disease activity in IBD. Methods This is a prospective cross-sectional study of IUS performed on IBD patients in a tertiary centre. IUS parameters including intestinal wall thickness, loss of wall stratification, mesenteric
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Incidence and clinical characteristics of pediatric inflammatory bowel disease in Oman. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Tawfiq Taki Al Lawati,Yusriya Al Rawahi,Al Qasim Al Bahlani,Adawiya Al Jamei,Dafalla Ramatalla,Omar I Saadah
Background Pediatric inflammatory bowel disease (PIBD) has been documented all over the world, and there is now a large body of clinical, pathological, and treatment knowledge and protocols in place in many countries. There is currently limited knowledge on the prevalence and pathology of PIBD in Omani population. The aim of this study is to report the incidence and clinical features of PIBD in Oman
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Gut virome profile in healthy Saudi children. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Mohammad I El Mouzan,Asaad A Assiri,Ahmed A Al Sarkhy,Mona M Alasmi
Background The role of viruses is well known in health and disease. The aim of this report was to describe the profile of viruses in the gut of healthy Saudi children. Methods In 20 randomly selected school age children from Riyadh, stool samples were collected in cryovials and stored at -80° C. At the time of analysis, the samples were sent by express mail in a temperature-controlled container to
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Urinary coproporphyrins as a diagnostic biomarker of Dubin-Johnson syndrome in neonates: A diagnostic pathway is proposed. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Abdulrahman Al-Hussaini,Ali Asery,Omar Alharbi
Background Dubin-Johnson syndrome (DJS) presents during the neonatal period with a phenotype that overlaps with a broad list of causes of neonatal cholestasis (NC), which makes the identification of DJS challenging for clinicians. We conducted a case-controlled study to investigate the utility of urinary coproporphyrins (UCP) I% as a potential diagnostic biomarker. Methods We reviewed our database
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Exploring treatment of inflammatory bowel disease with infliximab in the Middle East and Northern Africa: An analysis of the HARIR observational cohort study. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Othman Alharbi,Waleed Hamed,Osama Salem,Catherine Taylor,Ahmed Besar,Mohamed Sharaf
Background In 2017, inflammatory bowel disease, including Crohn's disease (CD) and ulcerative colitis (UC) affected more than 6.8 million people worldwide, with increased incidence in newly industrialized countries. Although treatment options were previously limited to symptom reduction, current approaches benefit from disease-modifying biologics. In this study, we aimed to explore disease characteristics
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Inflammatory bowel disease in the elderly: A focus on disease characteristics and treatment patterns. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Mahmoud H Mosli,Maha K Alghamdi,Omar A Bokhary,Maria A Alzahrani,Siba Z Takieddin,Tala A Galai,Majid A Alsahafi,Omar I Saadah
Background As the population ages, the number of elderly inflammatory bowel disease (IBD) patients is expected to increase. The clinical features and therapeutic options for young and old patients may differ, as elderly IBD patients are likely to have different comorbidities and disease characteristics. The goal of this study was to examine the clinical aspects and therapeutic choices for elderly Saudi
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Composition of the gut microbiota in patients with inflammatory bowel disease in Saudi Arabia: A pilot study. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Hadba Al-Amrah,Omar I Saadah,Mahmoud Mosli,Vito Annese,Rashad Al-Hindi,Sherif Edris,Dikhnah Alshehri,Hanan Alatawi,Marfat Alatawy,Ahmad Bahieldin
Conclusions The results of this study provide an overview of the variations in microbiota diversity present in Saudi IBD patients compared to healthy controls. Results The key finding was three negative bacterial biomarkers, Paraprevotellaceae, the Muribaculaceae families of Bacteroidetes phylum, and the Leuconostocaceae family of Firmicutes phylum, which had a higher relative abundance in healthy
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Periampullary diverticulum in endoscopic retrograde cholangiopancreatography: A paper tiger? Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-18 Tarek Z Arabi,Aymen Almuhaidb
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Unlocking the path to efficient H. pylori eradication: Embracing potassium-competitive acid blockers (P-CABs). Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Thomas J Borody,John Ng,Sibasish Dolai
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Disease patterns among Saudi children undergoing colonoscopy for lower gastrointestinal bleeding: Single tertiary care center experience. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Sami Alrashidi,Tarig AlAmery,Abdullah Alshanbary,Eman Aljohani,Salman M Bashir,Bader Alsaleem,Ali Asery,Abdulrahman Al-Hussaini
Background : The yield of colonoscopy in cases presenting with lower gastrointestinal bleeding (LGIB) in previously published studies varies according to several factors, including endoscopic skills, histopathological experience, and pattern of colonic pathology in different countries. The local literature is limited to a single small 20-year-old study. Our objective was to provide updated data on
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Correlation between physician- and patient-directed disease assessments in ulcerative colitis patients from Saudi Arabia and Kuwait: Data from ICONIC. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Othman Al Harbi,Salem Owayed,Yousif Qari,Mahmoud Mosli,Ali Anwar,Alaa Masri,Mohamed Gouda,Ahmed Alfadhli
Background The aim of the observational, prospective study was to validate a novel, nonverbal assessment tool for perceived disease burden-Pictorial Representation of Illness and Self-Measure (PRISM)-in ulcerative colitis (UC) against established patient health questionnaires. The cumulative burden of patients recently diagnosed (<3 years) with UC was also evaluated. Methods "ICONIC" - Understanding
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Comparison of KRAS gene in circulating tumor DNA levels vs histological grading of colorectal cancer patients through liquid biopsy. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Hafiz Syed Mohammad Osama Jafri,Shamim Mushtaq,Saeeda Baig,Afreen Bhatty,Sabra Siraj
Background To determine KRAS gene in circulating tumor DNA in comparison with histological grading through liquid biopsy in colorectal cancer patients. Methods This dual-centered cross-sectional study included 73 diagnosed patients of colorectal cancer at different grading levels [Grade I, well differentiated (n = 7, 9.5%); Grade II, moderately differentiated (n = 14,18.9%); and Grade III, poorly differentiated
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Vonoprazan-amoxicillin dual therapy for Helicobacter pylori eradication: A systematic review and meta-analysis of randomized controlled trials. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Ben-Gang Zhou,Yu-Zhou Mei,Xin Jiang,Ai-Jing Zheng,Yan-Bing Ding
Background Vonoprazan-amoxicillin (VA) dual therapy has recently been proposed to eradicate Helicobacter pylori (H. pylori) with controversial results. We, therefore, conducted a meta-analysis to assess the effect of this therapy for H. pylori eradication. Methods We searched PubMed, Embase, Cochrane Library, and Web of Science database from inception until November 2022, collecting randomized controlled
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Acute peripancreatic fluid collection in acute pancreatitis: Incidence, outcome, and association with inflammatory markers. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Tevfik Solakoglu,Nurten Turkel Kucukmetin,Mustafa Akar,Hüseyin Koseoglu
Background The hospital outcomes and predictors of acute peripancreatic fluid collection (APFC) have not been well-characterized. In this study, we aimed to investigate the clinical outcomes of APFC in patients with acute pancreatitis (AP) and the role of the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and C-reactive protein (CRP) level in predicting the occurrence
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Analysis of high risk factors for chronic atrophic gastritis. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Xian-Ke Lin,Wei-Lin Wang
Background Screening for chronic atrophic gastritis (CAG) is crucial for the prevention and early detection of gastric cancer. Endoscopy is the main method of CAG diagnosis, with high training requirements and limited accuracy, making it difficult to popularize. The study attempts to improve the positive rate and accuracy of CAG screening through non-invasive testing. Methods A total of 2564 patients
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The impact of preoperative total parenteral nutrition on the surgical complications of Crohn's disease: A retrospective cohort study. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Thamer A Bin Traiki,Sulaiman A Alshammari,Nadia A Aljomah,Monirah M Alsalouli,Esraa S Altawil,Maha-Hamadien Abdulla,Noura S Alhassan,Khayal A Alkhayal
Background Crohn's disease (CD) is associated with malnutrition, an independent risk factor for surgical morbidity and mortality in more than 65% of patients, with a significant impact on disease outcomes. In this single-center retrospective cohort study, we aimed to investigate the impact of total parenteral nutrition (TPN) on the surgical outcomes of patients with CD. Methods This study included
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Radiomics signature for prediction of long-term survival and recurrence patterns in patients with gastric cancer after radical gastrectomy: A multicenter study. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-03 Jing-Min Huang,Lv-Ping Zhuang,Hua-Gen Wang,Li-Ying Zhong,Sheng-Jin Xue,Fang-Xi Tian,Hua-Yang Lin
Background This study aimed to develop and validate a radiomics score to predict the long-term survival and patterns of recurrence of gastric cancer (GC). Methods A total of 513 patients who underwent radical gastrectomy for GC after curative resection between 2008 and 2016 at two institutions were analyzed. A radiomics score was generated using the least absolute shrinkage and selection operator Cox
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Conventional versus hybrid knife endoscopic submucosal dissection in large colorectal laterally spreading tumors: A propensity score analysis. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Bin Yang,Jianhong Shen,Wuxue Zhong,Huazhong Han,Pinxiang Lu,Fei Jiang
Background Colorectal endoscopic submucosal dissection (CR-ESD) has become a promising treatment for laterally spreading tumors (LSTs), but is accompanied by great challenges. . This study aimed to evaluate the efficacy and safety of CR-ESD with a hybrid knife, versus the conventional technique for LSTs ≥30 mm in diameter, and analyze the risk factors for piecemeal resection and perforation. Methods
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In vitro and in vivo phototoxicity on gastric mucosa induced by methylene blue. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2022-12-27 Hui Yeong Oh,Hyun Ho Choi,Eui Jin Kim,Ji Hye Choi,Sung Sook Choi,Hae Kyung Lee,Hyung-Keun Kim,Sang Woo Kim,Won Sang H Park,Hiun Suk Chae
Background Methylene blue (MB) is used endoscopically to demarcate tumors and as a photosensitizer in photodynamic therapy (PDT). However, there are few in vivo studies about its toxicity in healthy stomach tissue. We performed sequential in vitro and in vivo analyses of MB-induced phototoxicity. Methods We performed in vitro experiments using the AGS human gastric cancer cell line treated with light-emitting
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Diagnostic performances of celiac disease serological tests among Saudi patients. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2022-12-27 Rim Sghiri,Hana Ben Hassine,Adel Almogren,Zahid Shakoor,Mohammed Alswayyed
Background : The prevalence of celiac disease (CD) is relatively high in Saudi Arabia, and little is known about the accuracy of serological markers in the local population. This study aimed to assess the diagnostic performance of various serological markers for detecting CD in Saudi children and adults. Methods We conducted a retrospective study of 148 CD patients and 512 controls to assess the diagnostic
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Saudi Arabia consensus guidance for the diagnosis and management of adults with inflammatory bowel disease. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2022-11-21 Mahmoud H Mosli,Hajer Y Almudaiheem,Turki AlAmeel,Shakir A Bakkari,Othman R Alharbi,Khalidah A Alenzi,Amr M Khardaly,Maha A AlMolaiki,Bedor A Al-Omari,Rayan G Albarakati,Ahmed H Al-Jedai,Omar I Saadah,Majid A Almadi,Badr Al-Bawardy
Optimal management of inflammatory bowel disease (IBD) relies on a clear understanding and tailoring evidence-based interventions by clinicians in partnership with patients. This article provides concise guidelines for the management of IBD in adults, based on the most up-to-date information at the time of writing and will be regularly updated. These guidelines were developed by the Saudi Ministry
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The CONUT score is prognostic in esophageal cancer treated with chemoradiotherapy. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2023-01-01 Metin Demir,Nazim Can Demircan
Background Malnutrition is a frequent issue in esophageal cancer (EC). The Controlling Nutritional Status (CONUT) Score has been established as a prognostic indicator in EC patients who underwent surgery. We aimed to investigate the role of the CONUT Score in EC patients treated with chemoradiotherapy (CRT). Methods The trial included 101 non-metastatic EC patients. Receiver operating characteristic
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Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review. Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2022-11-23 Hassan Mahmoudi,Hadi Hossainpour
Fecal microbiota transplantation (FMT) restores a balanced intestinal flora, which helps to cure recurrent Clostridium difficile infections (RCDI). FMT has also been used to treat other gastrointestinal diseases, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and chronic constipation, as well as a variety of non-GI disorders. The purpose of this review is to discuss gut
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Cholecystectomy for idiopathic acute pancreatitis: Not yet there! Saudi J. Gastroenterol. (IF 2.7) Pub Date : 2022-10-19 Nitin Jagtap,Sundeep Lakhtakia