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Urinary markers of Mycobacterium tuberculosis and dysbiosis in paediatric tuberculous meningitis cases undergoing treatment Gut Pathog. (IF 4.2) Pub Date : 2024-03-12 Simon Isaiah, Du Toit Loots, A. Marceline Tutu van Furth, Elmarie Davoren, Sabine van Elsland, Regan Solomons, Martijn van der Kuip, Shayne Mason
The pathogenesis of tuberculous meningitis (TBM) involves infection by Mycobacterium tuberculosis in the meninges and brain. However, recent studies have shown that the immune response and inflammatory processes triggered by TBM can have significant effects on gut microbiota. Disruptions in the gut microbiome have been linked to various systemic consequences, including altered immunity and metabolic
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A case–control study of the association between the gut microbiota and colorectal cancer: exploring the roles of diet, stress, and race Gut Pathog. (IF 4.2) Pub Date : 2024-03-11 Tiffany L. Carson, Doratha A. Byrd, Kristen S. Smith, Daniel Carter, Maria Gomez, Michael Abaskaron, Rebecca B. Little, Sh’Nese Townsend Holmes, William J. van Der Pol, Elliot J. Lefkowitz, Casey D. Morrow, Andrew D. Fruge
The gut microbiota is associated with risk for colorectal cancer (CRC), a chronic disease for which racial disparities persist with Black Americans having a higher risk of CRC incidence and mortality compared to other groups. Given documented racial differences, the gut microbiota may offer some insight into previously unexplained racial disparities in CRC incidence and mortality. A case–control analysis
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Identification of enterotype and its predictive value for patients with colorectal cancer Gut Pathog. (IF 4.2) Pub Date : 2024-02-27 Li Qingbo, Zhuang Jing, Qu Zhanbo, Chu Jian, Song Yifei, Wu Yinhang, Han Shuwen
Gut microbiota dysbiosis involved in the pathogenesis of colorectal cancer (CRC). The characteristics of enterotypes in CRC development have not been determined. To characterize the gut microbiota of healthy, adenoma, and CRC subjects based on enterotype. The 16 S rRNA sequencing data from 315 newly sequenced individuals and three previously published datasets were collected, providing total data for
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TRS-PCR profiles correlate with polymorphisms of the genomic o454-nlpD region, virulence factors repertoire, and phylogenetic groups among uropathogenic Escherichia coli strains isolated from patients from Lodz region, Poland Gut Pathog. (IF 4.2) Pub Date : 2024-02-23 Anna B. Kubiak-Szeligowska, Marta Majchrzak, Pawel Parniewski
Extraintestinal urinary tract infections are mainly caused by uropathogenic strains of E. coli. UPECs are a heterogeneous group of strains possessing various genes associated with virulence traits. It was demonstrated that changes in the composition of the o454-nlpD region and genetic variation in the mutS-rpoS chromosomal region in ExPEC strains are correlated with their virulence, particularly in
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Timing and clinical risk factors for early acquisition of gut pathogen colonization with multidrug resistant organisms in the intensive care unit Gut Pathog. (IF 4.2) Pub Date : 2024-02-21 Loren Shamalov, Madison Heath, Elissa Lynch, Daniel A. Green, Angela Gomez-Simmonds, Daniel E. Freedberg
Microbiome restitution therapies are being developed to prevent gut pathogen colonization among patients in the intensive care unit (ICU) and in other select populations. If preventive therapies are to be effective, they must be administered prior to pathogen acquisition. The timing and risk factors for early acquisition of gut pathogen colonization (within 72 h) are currently unknown and could be
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16S rRNA sequencing analysis of the oral and fecal microbiota in colorectal cancer positives versus colorectal cancer negatives in Iranian population Gut Pathog. (IF 4.2) Pub Date : 2024-02-20 Sama Rezasoltani, Mehdi Azizmohammad Looha, Hamid Asadzadeh Aghdaei, Seyedesomayeh Jasemi, Leonardo Antonio Sechi, Maria Gazouli, Amir Sadeghi, Shirin Torkashvand, Reyhaneh Baniali, Hartmut Schlüter, Mohammad Reza Zali, Mohammad Mehdi Feizabadi
Colorectal cancer (CRC) poses a significant healthcare challenge, accounting for nearly 6.1% of global cancer cases. Early detection, facilitated by population screening utilizing innovative biomarkers, is pivotal for mitigating CRC incidence. This study aims to scrutinize the fecal and salivary microbiomes of CRC-positive individuals (CPs) in comparison to CRC-negative counterparts (CNs) to enhance
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Intestinal metabolites predict treatment resistance of patients with depression and anxiety Gut Pathog. (IF 4.2) Pub Date : 2024-02-09 Juntaro Matsuzaki, Shunya Kurokawa, Chiaki Iwamoto, Katsuma Miyaho, Akihiro Takamiya, Chiharu Ishii, Akiyoshi Hirayama, Kenji Sanada, Shinji Fukuda, Masaru Mimura, Taishiro Kishimoto, Yoshimasa Saito
The impact of the gut microbiota on neuropsychiatric disorders has gained much attention in recent years; however, comprehensive data on the relationship between the gut microbiome and its metabolites and resistance to treatment for depression and anxiety is lacking. Here, we investigated intestinal metabolites in patients with depression and anxiety disorders, and their possible roles in treatment
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A systematic review and meta-analysis of protozoan parasite infections among patients with mental health disorders: an overlooked phenomenon Gut Pathog. (IF 4.2) Pub Date : 2024-01-28 Amir Abdoli, Meysam Olfatifar, Aida Vafae Eslahi, Zeinab Moghadamizad, Rasoul Samimi, Mohammad Amin Habibi, Amir Sam Kianimoghadam, Milad Badri, Panagiotis Karanis
Patients with mental disorders have a high risk of intestinal parasitic infection due to poor hygiene practices. Hence, to better clarify this overlooked phenomenon, the current study is conducted to determine the global prevalence of protozoan parasite infections in patients with mental disorders and investigate the associated risk factors. Several databases (PubMed, Scopus, Web of Science, ProQuest
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Cyclic-di-AMP confers an invasive phenotype on Escherichia coli through elongation of flagellin filaments Gut Pathog. (IF 4.2) Pub Date : 2024-01-24 Rika Tanaka, Jin Imai, Eiji Sugiyama, Shogo Tsubaki, Katsuto Hozumi, Hitoshi Tsugawa
Adherent-invasive Escherichia coli (AIEC) is isolated from patients with Crohn’s disease (CD). AIEC can invade the intestinal epithelium, suggesting that it is involved in the development and pathogenesis of CD. However, the mechanism by which AIEC acquired the invasive phenotype remains unknown. This study was designed to examine the mechanisms of AIEC invasiveness. We found that the flagellin (fliC)
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Gut microbial ecology and exposome of a healthy Pakistani cohort Gut Pathog. (IF 4.2) Pub Date : 2024-01-22 Farzana Gul, Hilde Herrema, Mark Davids, Ciara Keating, Arshan Nasir, Umer Zeeshan Ijaz, Sundus Javed
Pakistan is a multi-ethnic society where there is a disparity between dietary habits, genetic composition, and environmental exposures. The microbial ecology of healthy Pakistani gut in the context of anthropometric, sociodemographic, and dietary patterns holds interest by virtue of it being one of the most populous countries, and also being a Lower Middle Income Country (LMIC). 16S rRNA profiling
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A monoclonal antibody collection for C. difficile typing ? Gut Pathog. (IF 4.2) Pub Date : 2024-01-19 Lise Hunault, Patrick England, Frédéric Barbut, Bruno Iannascoli, Ophélie Godon, François Déjardin, Christophe Thomas, Bruno Dupuy, Chunguang Guo, Lynn Macdonald, Guy Gorochov, Delphine Sterlin, Pierre Bruhns
Clostridioides difficile is the leading cause of antibiotic-associated diarrhea and pseudomembranous colitis in adults. Various C. difficile strains circulate currently, associated with different outcomes and antibiotic resistance profiles. However, most studies still focus on the reference strain 630 that does not circulate anymore, partly due to the lack of immunological tools to study current clinically
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Comprehensive full genome analysis of norovirus strains from eastern India, 2017–2021 Gut Pathog. (IF 4.2) Pub Date : 2024-01-18 Mahadeb Lo, Yen Hai Doan, Suvrotoa Mitra, Ritubrita Saha, Shin-ichi Miyoshi, Kei Kitahara, Shanta Dutta, Tomoichiro Oka, Mamta Chawla-Sarkar
Worldwide, noroviruses are the leading cause of acute gastroenteritis (AGE) in people of all age groups. In India, norovirus rates between 1.4 to 44.4% have been reported. Only a very few complete norovirus genome sequences from India have been reported. To perform full genome sequencing of noroviruses circulating in India during 2017–2021, identify circulating genotypes, assess evolution including
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Temporal changes in the positivity rate of common enteric viruses among paediatric admissions in coastal Kenya, during the COVID-19 pandemic, 2019–2022 Gut Pathog. (IF 4.2) Pub Date : 2024-01-04 Arnold W. Lambisia, Nickson Murunga, Martin Mutunga, Robinson Cheruiyot, Grace Maina, Timothy O. Makori, D. James Nokes, Charles N. Agoti
The non-pharmaceutical interventions (NPIs) implemented to curb the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) early in the coronavirus disease 2019 (COVID-19) pandemic, substantially disrupted the activity of other respiratory viruses. However, there is limited data from low-and-middle income countries (LMICs) to determine whether these NPIs also impacted the transmission
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Bacteremia from streptococcus constellatus revealing a gastrointestinal stromal tumor Gut Pathog. (IF 4.2) Pub Date : 2024-01-04 Salvatore Chessa, Elena Belfiori, Giulia Mandis, Enrico Urru, Giovanna Manconi, Angelo Scuteri
Pyogenic Liver Abscesses (PLA) are the most common type of visceral abscess. They generally develop in a context of biliary disease or hematogenous seeding, but a complete diagnostic work-up is always required in order not to miss other important causes, including above all malignancies of the gastro-intestinal tract. Herein, we report a particular case of a 80 years-old immunocompetent woman hospitalized
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Gut microbiome dynamics and associations with mortality in critically ill patients Gut Pathog. (IF 4.2) Pub Date : 2023-12-19 Tarik J. Salameh, Katharine Roth, Lisa Schultz, Zhexi Ma, Anthony S. Bonavia, James R. Broach, Bin Hu, Judie A. Howrylak
Critical illness and care within the intensive care unit (ICU) leads to profound changes in the composition of the gut microbiome. The impact of such changes on the patients and their subsequent disease course remains uncertain. We hypothesized that specific changes in the gut microbiome would be more harmful than others, leading to increased mortality in critically ill patients. This was a prospective
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Microbiota promotes recruitment and pro-inflammatory response of caecal macrophages during E. tenella infection Gut Pathog. (IF 4.2) Pub Date : 2023-12-14 F. Tomal, A. Sausset, Y. Le Vern, L. Sedano, C. Techer, S. Lacroix-Lamandé, F. Laurent, A. Silvestre, F. I. Bussière
Eimeria genus belongs to the apicomplexan parasite phylum and is responsible for coccidiosis, an intestinal disease with a major economic impact on poultry production. Eimeria tenella is one of the most virulent species in chickens. In a previous study, we showed a negative impact of caecal microbiota on the physiopathology of this infection. However, the mechanism by which microbiota leads to the
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Antimicrobial growth promoters approved in food-producing animals in South Africa induce shiga toxin-converting bacteriophages from Escherichia coli O157:H7. Gut Pathog. (IF 4.2) Pub Date : 2023-12-06 Nomonde F. N. Ngoma, Mogaugedi N. Malahlela, Munyaradzi C. Marufu, Beniamino T. Cenci-Goga, Luca Grispoldi, Eric Etter, Alan Kalake, Musafiri Karama
In this study, four antimicrobial growth promoters, including virginiamycin, josamycin, flavophospholipol, poly 2-propenal 2-propenoic acid and ultraviolet light, were tested for their capacity to induce stx-bacteriophages in 47 Shiga toxin-producing E. coli O157:H7 isolates. Induced bacteriophages were characterized for shiga toxin subtypes and structural genes by PCR, DNA restriction fragment length
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Antibiotic-Resistant Arcobacter spp. in commercial and smallholder farm animals in Asante Akim North Municipality, Ghana and Korogwe Town Council, Tanzania: a cross-sectional study Gut Pathog. (IF 4.2) Pub Date : 2023-12-02 Ellis Kobina Paintsil, Linda Aurelia Ofori, Charity Wiafe Akenten, Andreas E. Zautner, Joyce Mbwana, Neyaz Ahmed Khan, John P. A. Lusingu, Joseph Kaseka, Daniel T. R. Minja, Samwel Gesase, Anna Jaeger, Maike Lamshöft, Jürgen May, Kwasi Obiri-Danso, Ralf Krumkamp, Denise Dekker
Arcobacter species are considered emerging foodborne pathogens that can potentially cause serious infections in animals and humans. This cross-sectional study determined the frequency of potentially pathogenic Arcobacter spp. in both commercial and smallholder farm animals in Ghana and Tanzania. A total of 1585 and 1047 (poultry and livestock) samples were collected in Ghana and Tanzania, respectively
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Hypoxia exacerbates intestinal injury and inflammatory response mediated by myeloperoxidase during Salmonella Typhimurium infection in mice Gut Pathog. (IF 4.2) Pub Date : 2023-11-30 Qinfang Zhu, Ying Han, Xiaozhou Wang, Ruhan Jia, Jingxuan Zhang, Meiheng Liu, Wei Zhang
High-altitude exposure can cause oxidative stress damage in the intestine, which leads to increased intestinal permeability and bacterial translocation, resulting in local and systemic inflammation. Control of infection is critically dependent on the host’s ability to kill pathogens with reactive oxygen species (ROS). Myeloperoxidase (MPO) targets ROS in pathogens. This study aimed to investigate the
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Vertebral osteomyelitis caused by Campylobacter jejuni in an immunocompetent patient Gut Pathog. (IF 4.2) Pub Date : 2023-11-30 Karina Frahm Kirk, Jeppe Boel, Hans Linde Nielsen
Campylobacter jejuni is the leading cause of human bacterial gastroenteritis worldwide. However, systemic infection with C. jejuni is uncommon, and osteomyelitis caused by C. jejuni is extremely rare. Cultivation from spinal bone biopsies has not previously been reported in the literature. A 79-year-old immunocompetent male was admitted to the emergency department at Aalborg University Hospital in
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Correction: The beneficial effects of commensal E. coli for colon epithelial cell recovery are related with Formyl peptide receptor 2 (Fpr2) in epithelial cells Gut Pathog. (IF 4.2) Pub Date : 2023-11-30 Keqiang Chen, John McCulloch, Rodrigo Das Neves, Gisele Rodrigues, Wang-Ting Hsieh, Wanghua Gong, Teizo Yoshimura, Jiaqiang Huang, Colm O’hUigin, Simone Diflippantonio, Matthew McCollum, Georgette Jones, Scott K. Durum, Giorgio Trinchieri, Ji Ming Wang
Correction: Gut Pathogens (2023) 15:28 https://doi.org/10.1186/s13099-023-00557-w In this article [1] the author name Gisele Rodrigues was incorrectly written as Gisele Roderigues. The original article has been corrected. Chen K, McCulloch J, Neves RD, Rodrigues G, Hsieh W-T, Gong W, Yoshimura T, Huang J, O’hUigin C, Diflippantonio S, McCollum M, Jones G, Durum SK, Trinchieri G, Wang JM. The beneficial
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Elevated plasma and bile levels of corisin, a microbiota-derived proapoptotic peptide, in patients with severe acute cholangitis Gut Pathog. (IF 4.2) Pub Date : 2023-11-30 Ryo Nishiwaki, Ichiro Imoto, Satoko Oka, Taro Yasuma, Hajime Fujimoto, Corina N. D’Alessandro-Gabazza, Masaaki Toda, Tetsu Kobayashi, Hataji Osamu, Kodai Fujibe, Kenichiro Nishikawa, Tetsuya Hamaguchi, Natsuko Sugimasa, Midori Noji, Yoshiyuki Ito, Kenji Takeuchi, Isaac Cann, Yasuhiro Inoue, Toshio Kato, Esteban C. Gabazza
Acute cholangitis is a severe, life-threatening infection of the biliary system that requires early diagnosis and treatment. The Tokyo Guidelines recommend a combination of clinical, laboratory, and imaging findings for diagnosis and severity assessment, but there are still challenges in identifying severe cases that need immediate intervention. The microbiota and its derived products have been implicated
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Retraction Note to: EV71 virus reduces Nrf2 activation to promote production of reactive oxygen species in infected cells Gut Pathog. (IF 4.2) Pub Date : 2023-11-28 Zhenzi Bai, Xiaonan Zhao, Chenghua Li, Chuanlun Sheng, Hongyan Li
Retraction to: Bai et al. Gut Pathog (2020) 12:22 https://doi.org/10.1186/s13099-020-00361-w. The editors have retracted this article. After publication, concerns were raised regarding similarities of western blots, fluorescence images and flow cytometry plots presented in Figs. 1, 2, 3, 4, 5, 6, 7 and 9 with other papers that were either published earlier or under consideration within a similar time
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Pathogenetic detection, retrospective and pathogenicity analysis of a fatal case of Vibrio vulnificus in Shenzhen, China Gut Pathog. (IF 4.2) Pub Date : 2023-11-25 Shiqin Xu, Jinsong Wu, Ying Jin, Liyin Ji, Xuan Zou, Qinghua Hu, Tiejian Feng, Shuang Wu, Yixiang Jiang, Qiongcheng Chen, Huiqun Lu, Shuxiang Qiu, Huaisheng Chen, Min Jiang, Rui Cai, Yaqun Qiu, Xiaolu Shi
We report a 36-year-old male patient died of V. vulnificus-induced septicaemia and multiple organ failure syndrome after oyster consumption at a restaurant. We isolated and identified V. vulnificus vv16015 from the patient’s blood sample and antibiotic susceptibility tests indicated sensitivity to all 21 antibiotics. Oyster samples were subsequently collected from the restaurant’s supplier and three
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1H-NMR based-metabolomics reveals alterations in the metabolite profiles of chickens infected with ascarids and concurrent histomonosis infection Gut Pathog. (IF 4.2) Pub Date : 2023-11-17 Oyekunle John Oladosu, Banny Silva Barbosa Correia, Beatrice Grafl, Dieter Liebhart, Cornelia C. Metges, Hanne Christine Bertram, Gürbüz Daş
Gut infections of chickens caused by Ascaridia galli and Heterakis gallinarum are associated with impaired host performance, particularly in high-performing genotypes. Heterakis gallinarum is also a vector of Histomonas meleagridis that is often co-involved with ascarid infections. Here, we provide a first insight into the alteration of the chicken plasma and liver metabolome as a result of gastrointestinal
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Strain-resolved metagenomic analysis of the gut as a reservoir for bloodstream infection pathogens among premature infants in Singapore Gut Pathog. (IF 4.2) Pub Date : 2023-11-16 Sarah M. Heston, Charis Shu En Lim, Chengsi Ong, Mei Chien Chua, Matthew S. Kelly, Kee Thai Yeo
Gut dysbiosis contributes to the high risk of bloodstream infection (BSI) among premature infants. Most prior studies of the premature infant gut microbiota were conducted in Western countries and prior to development of current tools for strain-resolved analysis. We performed metagenomic sequencing of weekly fecal samples from 75 premature infants at a single hospital in Singapore. We evaluated associations
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Correlation between gut microbiota composition, enteric infections and linear growth impairment: a case–control study in childhood stunting in Pidie, Aceh, Indonesia Gut Pathog. (IF 4.2) Pub Date : 2023-11-09 Tristia Rinanda, Catur Riani, Anita Artarini, Lucy Sasongko
Gut microbiota is pivotal in maintaining children's health and well-being. The ingestion of enteric pathogens and dysbiosis lead to Environmental Enteric Dysfunction (EED), which is essential in stunting pathogenesis. The roles of gut microbiome and enteric infections have not been explored comprehensively in relation to childhood stunting in Indonesia. This study aimed to determine the correlation
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The immune-adjunctive potential of recombinant LAB vector expressing murine IFNλ3 (MuIFNλ3) against Type A Influenza Virus (IAV) infection Gut Pathog. (IF 4.2) Pub Date : 2023-10-30 Sandeep Yadav, Aparna Varma, Aparna Odayil Muralidharan, Sucharita Bhowmick, Samiran Mondal, Amirul Islam Mallick
The conventional means of controlling the recurring pandemics of Type A Influenza Virus (IAV) infections remain challenging primarily because of its high mutability and increasing drug resistance. As an alternative to control IAV infections, the prophylactic use of cytokines to drive immune activation of multiple antiviral host factors has been progressively recognized. Among them, Type III Interferons
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Polymorphism of virulence genes and biofilm associated with in vitro induced resistance to clarithromycin in Helicobacter pylori Gut Pathog. (IF 4.2) Pub Date : 2023-10-28 Naim Asyraf Rosli, Anis Rageh Al-Maleki, Mun Fai Loke, Eng Guan Chua, Mohammed Abdelfatah Alhoot, Jamuna Vadivelu
Clarithromycin-containing triple therapy is commonly used to treat Helicobacter pylori infections. Clarithromycin resistance is the leading cause of H. pylori treatment failure. Understanding the specific mutations that occur in H. pylori strains that have evolved antibiotic resistance can help create a more effective and individualised antibiotic treatment plan. However, little is understood about
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Investigating the effect of the inhibitory peptide on L.monocytogenes cell invasion: an in silico and in vitro study Gut Pathog. (IF 4.2) Pub Date : 2023-10-25 Ali Shivaee, Sara Bahonar, Mehdi Goudarzi, Ali Hematian, Bahareh Hajikhani, Behrooz Sadeghi Kalani
L.monocytogenes monocytogenes is an omnipresent bacterium that causes a fatal food-borne illness, listeriosis. The connection of this bacterium to E-cadherin through internalin A plays a significant role in the internalization of the bacteria. In this study, this interaction has been investigated for the design of an inhibitory peptide. The interaction of the proteins involved in the entry of bacteria
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Gut microbiota and autism spectrum disorders: where do we stand? Gut Pathog. (IF 4.2) Pub Date : 2023-10-25 Sa’ed H. Zyoud, Muna Shakhshir, Amani S. Abushanab, Amer Koni, Moyad Shahwan, Ammar A. Jairoun, Adham Abu Taha, Samah W. Al-Jabi
Children with autism spectrum disorder (ASD) often have digestive problems and microbial imbalances in their guts, suggesting that these conditions may play a role in the development of the disorder. Scopus-based research on the gut microbiota and ASD was examined in this bibliometric analysis to shed light on the current state of research and identify potential hotspots for future work in this area
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Severe asthma patient with secondary Citrobacter koseri abdominal infection: first case report and review of the literature Gut Pathog. (IF 4.2) Pub Date : 2023-10-25 Mo Xian, Xiaolong Ji, Mingyu Zhong, Danhong Su, Jing Guan, Ruchong Chen
Citrobacter koseri (C. koseri) is a Gram-negative, motile, non-spore-forming facultative anaerobic bacillus belonging to the Enterobacteriaceae family. C. koseri typically utilizes citrate as the sole carbon source and constitutes part of the normal gastrointestinal flora in humans and animals. As an opportunistic pathogen, C. koseri infections are mainly observed in neonates, elderly individuals,
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miR-125a-5p regulates the sialyltransferase ST3GAL1 in murine model of human intestinal campylobacteriosis Gut Pathog. (IF 4.2) Pub Date : 2023-10-17 Angelina Kraski, Soraya Mousavi, Markus M. Heimesaat, Stefan Bereswill, Ralf Einspanier, Thomas Alter, Greta Gölz, Soroush Sharbati
Zoonotic microorganisms are increasingly impacting human health worldwide. Due to the development of the global population, humans and animals live in shared and progressively crowded ecosystems, which enhances the risk of zoonoses. Although Campylobacter species are among the most important bacterial zoonotic agents worldwide, the molecular mechanisms of many host and pathogen factors involved in
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Molecular characterization of Clostridium perfringens isolates from a tertiary children’s hospital in Guangzhou, China, establishing an association between bacterial colonization and food allergies in infants Gut Pathog. (IF 4.2) Pub Date : 2023-10-08 Kun-yi Huang, Bing-shao Liang, Xiao-yan Zhang, Huan Chen, Ni Ma, Jiao-li Lan, Ding-You Li, Zhen-wen Zhou, Min Yang
Cow’s milk protein allergy (CMPA) is one of the most common types of food allergy in infants. Faecal pathogen cultures showed that the positive rate of Clostridium perfringens was more than 30%, which was significantly higher than that for other bacteria. Therefore, it is speculated that Clostridium perfringens colonization may be one of the pathogenetic factors for CMPA in infants. We conducted a
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Establishment of persistent enteric mycobacterial infection following streptomycin pre-treatment Gut Pathog. (IF 4.2) Pub Date : 2023-10-03 Shannon C. Duffy, Andréanne Lupien, Youssef Elhaji, Mina Farag, Victoria Marcus, Marcel A. Behr
Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of paratuberculosis, a chronic gastrointestinal disease affecting ruminants. This disease remains widespread in part due to the limitations of available diagnostics and vaccines. A representative small animal model of disease could act as a valuable tool for studying its pathogenesis and to develop new methods for paratuberculosis
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A multi-omics study to investigate the progression of the Correa pathway in gastric mucosa in the context of cirrhosis Gut Pathog. (IF 4.2) Pub Date : 2023-09-26 Ruiguang Ma, Qian Li, Guoxian Yu, Jun Wang, Yueyue Li, Xinyan Xu, Yiqing Zhu, Min Dong, Yanjing Gao, Lixiang Li, Zhen Li
Patients with liver cirrhosis (LC) are prone to gastric mucosa damage. We investigated the alterations of gastric mucosa in LC patients and their possible mechanisms through multi-omics. We observed significant gastric mucosa microbial dysbiosis in LC subjects. Gastric mucosal microbiomes of LC patients contained a higher relative abundance of Streptococcus, Neisseria, Prevotella, Veillonella, and
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Whole-genome characterization of common rotavirus strains circulating in Vellore, India from 2002 to 2017: emergence of non-classical genomic constellations Gut Pathog. (IF 4.2) Pub Date : 2023-09-20 Shainey Alokit Khakha, Tintu Varghese, Sidhartha Giri, Alan Durbin, Gene S. Tan, Maheswari Kalaivanan, Jasmin Helan Prasad, Gagandeep Kang
Rotaviruses (RVs) are the most common etiological agent of acute gastroenteritis among young children, even after vaccine introduction in low-income countries. A whole-genome classification representing the 11 RV genes, was introduced for surveillance and characterization of RVs. This study characterized the common circulating strains in Vellore, India from 2002 to 2017 to understand rotavirus strain
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Comparative genomic analysis of Fusobacterium nucleatum reveals high intra-species diversity and cgmlst marker construction Gut Pathog. (IF 4.2) Pub Date : 2023-09-14 Qianhui Zhu, Arslan Dovletgeldiyev, Chen Shen, Kexin Li, Songnian Hu, Zilong He
Fusobacterium nucleatum is a one of the most important anaerobic opportunistic pathogens in the oral and intestinal tracts of human and animals. It can cause various diseases such as infections, Lemierre's syndrome, oral cancer and colorectal cancer. The comparative genomic studies on the population genome level, have not been reported. We analyzed all publicly available Fusobacterium nucleatums’ genomic
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The changing relationship between Cholera and interannual climate variables in Kolkata over the past century Gut Pathog. (IF 4.2) Pub Date : 2023-09-13 Debbie Shackleton, Fayyaz Ali Memon, Albert Chen, Shanta Dutta, Suman Kanungo, Alok Deb
In the Bengal Delta, research has shown that climate and cholera are linked. One demonstration of this is the relationship between interannual ocean-atmospheric oscillations such as the El Niño Southern Oscillation (ENSO) and the Indian Ocean Dipole (IOD). What remains unclear in the present literature is the nature of this relationship in the specific context of Kolkata, and how this relationship
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Production of highly immunogenic and safe Triton X-100 produced bacterial ghost vaccine against Shigella flexneri 2b serotype Gut Pathog. (IF 4.2) Pub Date : 2023-09-07 Amany Abdelfattah, Reham Samir, Heba M. Amin
Bacterial ghost cells (BGCs) are cells were drained of their genetic and cytoplasmic components. This work aimed to develop vaccine candidates against the Shigella flexneri (S. flexneri) 2b serotype using the BGCs approach. For the first time, (S. flexneri) 2b serotype BGCs vaccine was prepared by incubation with Triton X-100 (TX100) for only 12 h. Its safety and immunogenicity were compared to another
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Dysbiosis of gut microbiota during fecal stream diversion in patients with colorectal cancer Gut Pathog. (IF 4.2) Pub Date : 2023-08-18 Soo Young Lee, Hyeung-Min Park, Chang Hyun Kim, Hyeong Rok Kim
The effect of fecal stream diversion on the gut microbiota is still uncertain. The present study was designed to assess the effect of fecal stream diversion on the composition of the gut microbiota in patients with colorectal cancer. We included patients undergoing left-sided colorectal cancer surgery with (ileostomy group) or without (control group) diverting ileostomy. Fecal samples were collected
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Metagenomics revealed a correlation of gut phageome with autism spectrum disorder Gut Pathog. (IF 4.2) Pub Date : 2023-08-04 Khashayar Shahin, Abbas Soleimani-Delfan, Zihan He, Philippe Sansonetti, Jean-Marc Collard
The human gut bacteriome is believed to have pivotal influences on human health and disease while the particular roles associated with the gut phageome have not been fully characterized yet with few exceptions. It is argued that gut microbiota can have a potential role in autism spectrum disorders (ASD). The public microbiota database of ASD and typically developing (TD) Chinese individuals were analyzed
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A day-to-day management model improves patient compliance to treatment for Helicobacter pylori infection: a prospective, randomized controlled study Gut Pathog. (IF 4.2) Pub Date : 2023-07-31 Zhen Yang, Wenjie Xiong, Ruoyun Yang, Haisheng Qian, Zhi He, Meihong Chen, Jiajia Yang, Huaiming Sang, Jin Yan, Xiaobing Xu, Yun Wang, Guoxin Zhang, Feng Ye
The day-to-day (DTD) management model encourages patients to actively participate in their healthcare by setting goals. We determined the effectiveness of the DTD model in the treatment of Helicobacter pylori (H. pylori) infection, as compared with conventional outpatient education (OE). We randomized 254 H. pylori-positive patients into a DTD group (127 patients) and an OE group (127 patients) prior
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Risk factors for gut colonization with vancomycin-resistant enterococci among Bulgarian critically ill patients Gut Pathog. (IF 4.2) Pub Date : 2023-07-26 Preslava M. Hristova, Teodora V. Marinova-Bulgaranova, Tanya V. Strateva, Stefan V. Trifonov, Hristina Y. Hitkova
Vancomycin-resistant enterococci (VRЕ) are recognized as important hospital pathogens which have become common in patients admitted to the intensive care units (ICUs). The purpose of this study was to evaluate the incidence of and the risk factors for colonization with VRE among ICU patients. A total of 91 patients who had duration of hospitalization more than 48 h and without infection caused by VRE
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Effects of synbiotic supplementation on intestinal microbiota composition in children and adolescents with exogenous obesity: (Probesity-2 trial) Gut Pathog. (IF 4.2) Pub Date : 2023-07-21 Gonca Kilic Yildirim, Meltem Dinleyici, Yvan Vandenplas, Ener Cagri Dinleyici
Gut microbiota manipulation may be a potential therapeutic target to reduce host energy storage. There is limited information about the effects of probiotics/synbiotics on intestinal microbiota composition in children and adolescents with obesity. The objective of this randomized double-blind placebo-controlled trial was to test the effects of a multispecies synbiotic on intestinal microbiota composition
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Gut microbes involvement in gastrointestinal cancers through redox regulation Gut Pathog. (IF 4.2) Pub Date : 2023-07-13 Wang Yangyanqiu, Chu Jian, Yang Yuqing, Qu Zhanbo, Han Shuwen
Gastrointestinal (GI) cancers are among the most common and lethal cancers worldwide. GI microbes play an important role in the occurrence and development of GI cancers. The common mechanisms by which GI microbes may lead to the occurrence and development of cancer include the instability of the microbial internal environment, secretion of cancer-related metabolites, and destabilization of the GI mucosal
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Correction: Recent five-year progress in the impact of gut microbiota on vaccination and possible mechanisms Gut Pathog. (IF 4.2) Pub Date : 2023-07-10 Biqing Huang, Jianwei Wang, Lanjuan Li
Correction: Gut Pathogens (2023) 15:27 https://doi.org/10.1186/s13099-023-00547-y Following publication of the original article [1], it was noted that corrections to the corresponding author, affiliation information, and funding note were missed in the published version of the article. It has been corrected in this correction. 1. The corresponding author should be Dr. Lanjuan Li only. 2. The correct
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Gut microbiota signatures and fecal metabolites in postmenopausal women with osteoporosis Gut Pathog. (IF 4.2) Pub Date : 2023-07-06 Han Wang, Jing Liu, Zuoxing Wu, Yangyang Zhao, Man Cao, Baohong Shi, Baolong Chen, Ning Chen, Hao Guo, Na Li, Jian Chen, Ren Xu
Women suffer from various distress and disturbances after menopause, including osteoporosis, a risk factor associated with multiple diseases. Altered gut microbiota has been implicated in postmenopausal osteoporosis. In this study, to understand gut microbiota signatures and fecal metabolite changes in postmenopausal women with osteoporosis, 108 postmenopausal women were recruited for intestinal microbiota
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TRIM32 reduced the recruitment of innate immune cells and the killing capacity of Listeria monocytogenes by inhibiting secretion of chemokines Gut Pathog. (IF 4.2) Pub Date : 2023-07-06 Xuan OuYang, Peng Liu, Yuling Zheng, Hua Jiang, Qingyu Lv, Wenhua Huang, Huaijie Hao, Yaya Pian, Decong Kong, Yongqiang Jiang
Listeria monocytogenes (Lm) is a facultative, intracellular Gram-positive pathogenic bacterium that causes sepsis, a condition characterized by persistent excessive inflammation and organ dysfunction. However, the pathogenesis of Lm-induced sepsis is unknown. In this research, we discovered that TRIM32 is required for innate immune regulation during Lm infection. Trim32 deficiency remarkably reduced
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Clostridioides difficile infection in infants: a case report and literature review Gut Pathog. (IF 4.2) Pub Date : 2023-06-29 Zhirong Li, Ning Dong, Jihong Hao, Zirou Ouyang, Cuixin Qiang, Ying Yang, Chaoyi Mi, Yanan Niu, Jing Yang, Baojiang Wen, Liwei Wang, Shaodan Zhang, Jianhong Zhao
Clostridioides difficile (C. difficile) is the major pathogen causing antibiotic-associated diarrhea. There are a variety of symptoms associated with C. difficile infection (CDI) in adults, including self-limiting diarrhea, pseudomembranous colitis, toxic megacolon, septic shock, and even death from the infection. However, the infant’s intestine appears to be completely resistant to the effects of
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The interactions of Candida albicans with gut bacteria: a new strategy to prevent and treat invasive intestinal candidiasis Gut Pathog. (IF 4.2) Pub Date : 2023-06-27 Fei Wang, Zetian Wang, Jianguo Tang
The gut microbiota plays an important role in human health, as it can affect host immunity and susceptibility to infectious diseases. Invasive intestinal candidiasis is strongly associated with gut microbiota homeostasis. However, the nature of the interaction between Candida albicans and gut bacteria remains unclear. This review aimed to determine the nature of interaction and the effects of gut bacteria
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Correction: Diversity and composition of gut microbiota in healthy individuals and patients at different stages of hepatitis B virus-related liver disease Gut Pathog. (IF 4.2) Pub Date : 2023-06-17 Meng-Ju Lin, Tung-Hung Su, Chieh-Chang Chen, Wei-Kai Wu, Shih-Jer Hsu, Tai-Chung Tseng, Sih-Han Liao, Chun-Ming Hong, Hung-Chih Yang, Chun-Jen Liu, Ming-Shiang Wu, Jia-Horng Kao
Correction: Gut Pathogens (2023) 15:24 https://doi.org/10.1186/s13099-023-00549-w Following publication of the original article [1], it was noted that due to a typesetting mistake, errors were introduced in the caption of Additional files 5–7 in the Supplementary information. The publisher apologises to the authors and readers for the inconvenience caused by the error. That is, “HBeAgchronic HBV infection”
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The beneficial effects of commensal E. coli for colon epithelial cell recovery are related with Formyl peptide receptor 2 (Fpr2) in epithelial cells Gut Pathog. (IF 4.2) Pub Date : 2023-06-15 Keqiang Chen, John McCulloch, Rodrigo Das Neves, Gisele Roderigues, Wang-Ting Hsieh, Wanghua Gong, Teizo Yoshimura, Jiaqiang Huang, Colm O’hUigin, Simone Difilippantonio, Matthew McCollum, Georgette Jones, Scott K. Durum, Giorgio Trinchieri, Ji Ming Wang
Formyl peptide receptor 2 (Fpr2) plays a crucial role in colon homeostasis and microbiota balance. Commensal E. coli is known to promote the regeneration of damaged colon epithelial cells. The aim of the study was to investigate the connection between E. coli and Fpr2 in the recovery of colon epithelial cells. The deficiency of Fpr2 was associated with impaired integrity of the colon mucosa and an
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Recent five-year progress in the impact of gut microbiota on vaccination and possible mechanisms Gut Pathog. (IF 4.2) Pub Date : 2023-06-12 Biqing Huang, Jianwei Wang, Lanjuan Li
Vaccine is the most effective way to prevent the spread of communicable diseases, but the immune response induced by it varies greatly between individuals and populations in different regions of the world. Current studies have identified the composition and function of the gut microbiota as key factors in modulating the immune response to vaccination. This article mainly reviews the differences in
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Single-cell RNA sequencing reveals the mediatory role of cancer-associated fibroblast PTN in hepatitis B virus cirrhosis-HCC progression Gut Pathog. (IF 4.2) Pub Date : 2023-05-31 Chenhong Lin, Yeda Chen, Feng Zhang, Peng Zhu, Liangliang Yu, Wenbiao Chen
Cancer-associated fibroblasts (CAFs) are essential stromal components in the tumor microenvironment of hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) infection induces pathological changes such as liver fibrosis/cirrhosis and HCC. The aim of this research was to explore the novel mediators of CAFs to modulate HBV cirrhosis-HCC progression. The single-cell transcriptome data of HCC were divided
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Management of dyspepsia and Helicobacter pylori infection: the 2022 Indonesian Consensus Report Gut Pathog. (IF 4.2) Pub Date : 2023-05-22 Ari Fahrial Syam, Muhammad Miftahussurur, Dadang Makmun, Murdani Abdullah, Abdul Aziz Rani, Gontar Alamsyah Siregar, Marcellus Simadibrata, Nasrul Zubir, I. Dewa Nyoman Wibawa, Hery Djagat Purnomo, Chudahman Manan, Dharmika Djojoningrat, Achmad Fauzi, Kaka Renaldi, Hasan Maulahela, Amanda Pitarini Utari, Rabbinu Rangga Pribadi, Virly Nanda Muzellina, Saskia Aziza Nursyirwan, Muhammad Firhat Idrus,
Dyspepsia still becomes a major challenge in upper gastrointestinal disease in Indonesia. This disease often correlated with Helicobacter pylori infection. However, the prevalence of this bacterium is generally low in Indonesia. Therefore, several considerations should be taken into consideration during the management of dyspepsia and H. pylori infection. “Management of dyspepsia and H. pylori infection
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Diversity and composition of gut microbiota in healthy individuals and patients at different stages of hepatitis B virus-related liver disease Gut Pathog. (IF 4.2) Pub Date : 2023-05-22 Meng-Ju Lin, Tung-Hung Su, Chieh-Chang Chen, Wei-Kai Wu, Shih-Jer Hsu, Tai-Chung Tseng, Sih-Han Liao, Chun-Ming Hong, Hung-Chih Yang, Chun-Jen Liu, Ming-Shiang Wu, Jia-Horng Kao
Hepatitis B virus (HBV) causes chronic hepatitis B (CHB), liver cirrhosis, and hepatocellular carcinoma. The evolution of human gut microbiota during the progression of HBV-related liver diseases remains unclear. Therefore, we prospectively enrolled patients with HBV-related liver diseases and healthy individuals. Through 16S ribosomal RNA amplicon sequencing, we characterized the gut microbiota of
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Therapeutic and prophylactic effects of oral administration of probiotic Enterococcus faecium Smr18 in Salmonella enterica-infected mice Gut Pathog. (IF 4.2) Pub Date : 2023-05-18 Muzamil Rashid, Anmol Narang, Shubham Thakur, Subheet Kumar Jain, Sukhraj Kaur
Salmonella enterica serotype Typhi causes chronic enteric fever known as typhoid. Prolonged treatment regimen used for the treatment of typhoid and indiscriminate use of antibiotics has led to the emergence of resistant strains of S. enterica that has further increased the severity of the disease. Therefore, alternative therapeutic agents are urgently required. In this study, probiotic and enterocin-producing
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Association of gut microbial dysbiosis with disease severity, response to therapy and disease outcomes in Indian patients with COVID-19 Gut Pathog. (IF 4.2) Pub Date : 2023-05-10 Daizee Talukdar, Purbita Bandopadhyay, Yogiraj Ray, Shekhar Ranjan Paul, Jafar Sarif, Ranit D’Rozario, Abhishake Lahiri, Santanu Das, Debaleena Bhowmick, Shilpak Chatterjee, Bhabatosh Das, Dipyaman Ganguly
Severe coronavirus disease 2019 (COVID-19) is associated with systemic hyper-inflammation. An adaptive interaction between gut microbiota and host immune systems is important for intestinal homeostasis and systemic immune regulation. The association of gut microbial composition and functions with COVID-19 disease severity is sparse, especially in India. We analysed faecal microbial diversity and abundances
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Emerging applications of phage therapy and fecal virome transplantation for treatment of Clostridioides difficile infection: challenges and perspectives Gut Pathog. (IF 4.2) Pub Date : 2023-05-09 Hamideh Raeisi, Maryam Noori, Masoumeh Azimirad, Seyed Reza Mohebbi, Hamid Asadzadeh Aghdaei, Abbas Yadegar, Mohammad Reza Zali
Clostridioides difficile, which causes life-threatening diarrheal disease, is considered an urgent threat to healthcare setting worldwide. The current standards of care solely rely on conventional antibiotic treatment, however, there is a risk of promoting recurrent C. difficile infection (rCDI) because of the emergence of antibiotic-resistant strains. Globally, the alarming spread of antibiotic-resistant