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Impact of functional status on development of Clostridioides difficile infection and increase in in-hospital mortality among antibiotic users. Digestion (IF 3.2) Pub Date : 2023-11-23 Kenta Watanabe,Tsuyotoshi Tsuji,Yohei Saruta,Hisanori Matsuzawa,Yosuke Shimodaira,Katsunori Iijima
INTRODUCTION Functional status is one of the surrogates of advanced age, an established risk factor for Clostridioides difficile infection (CDI). We aimed to investigate the usefulness of functional status in the clinical management of CDI. METHODS We enrolled all hospitalized adult patients receiving antibiotics from a retrospective hospital-based cohort in Japan between 2016 and 2020. Using the Barthel
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Classification of colorectal cancer subtypes based on endoplasmic reticulum stress. Digestion (IF 3.2) Pub Date : 2023-11-23 Zhanbo Qu,Jian Chu,Yinhang Wu,Jing Zhuang,Jiang Liu,Shugao Han,Wei Wu,Shuwen Han
INTRODUCTION Endoplasmic reticulum stress (ERS) is associated with the occurrence and development of colorectal cancer (CRC). METHODS One thousand nine CRC samples and 3 ERS gene sets from GEO database were used to screen and validate genes related to stage and prognosis of CRC. Twenty thousand five hundred thirty samples from the TCGA database validated the ERS genes related to prognosis. PPI network
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Gut Frailty: Its Concept and Pathogenesis. Digestion (IF 3.2) Pub Date : 2023-11-15 Yuji Naito
BACKGROUND There is still a considerable gap between average life expectancy and healthy life expectancy in Japan. Recent research has revealed that gut frailty may be a worsening factor for various diseases, a cause of chronic inflammation, and a precursor to frailty. SUMMARY Among self-reported symptoms, constipation is particularly significant as one of the key symptoms of gut frailty. Studies have
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Modulation of Intestinal Motility in an Adolescent Rat Model of Irritable Bowel Syndrome. Digestion (IF 3.2) Pub Date : 2023-11-14 Reiko Kyodo,Takahiro Kudo,Natsuki Ito,Kazuhide Tokita,Nobuyasu Arai,Masamichi Sato,Tamaki Ikuse,Keisuke Jimbo,Yoshikazu Ohtsuka,Toshiaki Shimizu
INTRODUCTION The pathophysiology of irritable bowel syndrome (IBS) remains unknown. This study aimed to evaluate colonic motility and serotonin system response to restraint stress (RS) among adolescent rats who underwent neonatal maternal separation (NMS) to clarify the features of pathogenesis in adolescents with IBS. METHODS Male rats were exposed to NMS as chronic stress, and a normally handled
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Esophageal Dilation in Patients with Achalasia Is a Predictive Factor for the Inability to Traverse the Esophagogastric Junction with a Manometric Catheter. Digestion (IF 3.2) Pub Date : 2023-10-27 Yoshimasa Hoshikawa,Eri Momma,Noriyuki Kawami,Katsuhiko Iwakiri
INTRODUCTION The insertion of a high-resolution manometry (HRM) catheter into the stomach is essential for accurate manometric diagnoses; however, it is impossible in some cases due to the inability to traverse the esophagogastric junction (EGJ). Predictive factors for these patients have not been investigated in detail, necessitating time-consuming and burdensome procedures for investigators and patients
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Belching Disorders and Rumination Syndrome: A Literature Review. Digestion (IF 3.2) Pub Date : 2023-10-16 Akinari Sawada,Yasuhiro Fujiwara
BACKGROUND Belching disorders and rumination syndrome (RS) are disorders of gut-brain interaction (DGBIs) in Rome IV. Belching disorders are composed of excessive gastric belching (GB) and supragastric belching (SGB). Excessive GB is related to physiological phenomenon whereas excessive SGB and RS are behavioral disorders. SUMMARY A recent large internet survey found that prevalence of belching disorders
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Brain Neuropeptides, Neuroinflammation, and Irritable Bowel Syndrome. Digestion (IF 3.2) Pub Date : 2023-09-06 Masatomo Ishioh,Tsukasa Nozu,Toshikatsu Okumura
BACKGROUND Irritable bowel syndrome (IBS) is a functional bowel disorder characterized by chronic abdominal symptoms, but its pathogenesis is not fully understood. SUMMARY We have recently shown in rats that neuropeptides such as orexin, ghrelin, and oxytocin act in the brain to improve the intestinal barrier dysfunction, which is a major pathophysiology of IBS. We have additionally shown that the
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Usefulness and Educational Benefit of a Virtual Scale Endoscope in Measuring Colorectal Polyp Size. Digestion (IF 3.2) Pub Date : 2023-09-05 Yudai Takehara,Ken Yamashita,Shin Morimoto,Fumiaki Tanino,Noriko Yamamoto,Yuki Kamigaichi,Hidenori Tanaka,Hidehiko Takigawa,Ryo Yuge,Yuji Urabe,Shiro Oka
INTRODUCTION The virtual scale endoscope (VSE) is a newly introduced endoscope that helps endoscopists in measuring colorectal polyp size (CPS) during colonoscopy by displaying a virtual scale. This study aimed to determine the usefulness of the VSE for CPS measurement and the educational benefit of using VSE images to improve CPS estimation accuracy. METHODS This study included 42 colorectal polyps
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Endoscopic Resection with One-Port Placement: A Newly Developed Technique for the Safe Management of Advanced Endoscopic Resection for Gastric Gastrointestinal Stromal Tumors. Digestion (IF 3.2) Pub Date : 2023-08-30 Atsushi Sawada,Kingo Hirasawa,Chiko Sato,Sho Sato,Tsutomu Sato,Kazuya Sugimori,Chikara Kunisaki,Shin Maeda
INTRODUCTION Endoscopic full-thickness resection (EFTR) without laparoscopic assistance (pure EFTR) is an emerging, less invasive treatment for gastrointestinal stromal tumors (GISTs). However, the technique has seldom been performed outside China because of concerns regarding pneumoperitoneum, maintenance of endoscopic view, and endoscopic suturing. This study aimed to evaluate the efficacy and safety
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Esophageal Motility Disorders: Diagnosis and Treatment Strategies. Digestion (IF 3.2) Pub Date : 2023-08-25 Yoshimasa Hoshikawa,Katsuhiko Iwakiri
BACKGROUND Esophageal motility disorders (EMDs) are caused by the impaired relaxation of the upper/lower esophageal sphincter and/or defective esophageal peristaltic contractions, resulting in dysphagia and noncardiac chest pain. High-resolution manometry (HRM) is essential for the diagnosis of primary EMD; however, the recognition of EMD and HRM by general practitioners in Japan is limited. This review
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Gastrointestinal Angiodysplasia in Patients with Severe Aortic Stenosis: The Endoscopic Features of Heyde's Syndrome. Digestion (IF 3.2) Pub Date : 2023-08-24 Satoshi Sugino,Ken Inoue,Kan Zen,Masaki Yashige,Reo Kobayashi,Kazuaki Takamatsu,Nobuyasu Ito,Naoto Iwai,Ryohei Hirose,Toshifumi Doi,Osamu Dohi,Naohisa Yoshida,Kazuhiko Uchiyama,Tomohisa Takagi,Takeshi Ishikawa,Hideyuki Konishi,Satoaki Matoba,Yoshito Itoh
INTRODUCTION Aortic stenosis (AS) is sometimes associated with gastrointestinal bleeding, and this phenomenon is known as Heyde's syndrome. Such bleeding is most often considered to originate from gastrointestinal angiodysplasias, but the frequency and endoscopic features of such bleeding remain unclear. This study aimed to determine the frequency and endoscopic features of gastrointestinal angiodysplasia
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Reduced DEFA5 Expression and STAT3 Activation Underlie the Submucosal Invasion of Early Gastric Cancers. Digestion (IF 3.2) Pub Date : 2023-08-18 Sayaka Nagao,Yu Takahashi,Tamami Denda,Yukihisa Tanaka,Yuko Miura,Hiroya Mizutani,Daisuke Ohki,Yoshiki Sakaguchi,Seiichi Yakabi,Yosuke Tsuji,Keiko Niimi,Naomi Kakushima,Nobutake Yamamichi,Yasunori Ota,Kazuhiko Koike,Mitsuhiro Fujishiro
INTRODUCTION Submucosal invasion is a core hallmark of early gastric cancer (EGC) with poor prognosis. However, the molecular mechanism of the progression from intramucosal gastric cancer (IMGC) to early submucosal-invasive gastric cancer (SMGC) is not fully understood. The objective of this study was to identify genes and pathways involved in the submucosal invasion in EGC using comprehensive gene
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Functional Dyspepsia: Current Understanding and Future Perspective. Digestion (IF 3.2) Pub Date : 2023-08-18 Tadayuki Oshima
BACKGROUND Functional dyspepsia (FD) is a common disorder characterized by chronic or recurrent upper abdominal pain or discomfort without any structural abnormalities in the gastrointestinal tract. FD is categorized into two subgroups based on symptoms: postprandial distress syndrome (PDS) and epigastric pain syndrome. SUMMARY The pathophysiology of FD involves several mechanisms. Delayed gastric
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Frontiers in Endoscopic Treatment for Gastroesophageal Reflux Disease. Digestion (IF 3.2) Pub Date : 2023-08-17 Kazuhiro Ota,Toshihisa Takeuchi,Kazuhide Higuchi,Shun Sasaki,Yosuke Mori,Hironori Tanaka,Akitoshi Hakoda,Noriaki Sugawara,Taro Iwatsubo,Hiroki Nishikawa
BACKGROUND The 3rd edition of the evidence-based clinical practice guidelines for gastroesophageal reflux disease (GERD) 2021 from the Japanese Society of Gastroenterology states that the treatment strategy for potassium-competitive acid blocker (PCAB)-refractory GERD remains unclear. Furthermore, even if GERD improves with the administration of an acid secretion inhibitor, it is feared that GERD may
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LONG-HOSP Score: A Novel Predictive Score for Length of Hospital Stay in Acute Lower Gastrointestinal Bleeding - A Multicenter Nationwide Study. Digestion (IF 3.2) Pub Date : 2023-08-03 Minoru Fujita,Tomonori Aoki,Noriaki Manabe,Yoichiro Ito,Katsumasa Kobayashi,Atsushi Yamauchi,Atsuo Yamada,Jun Omori,Takashi Ikeya,Taiki Aoyama,Naoyuki Tominaga,Yoshinori Sato,Takaaki Kishino,Naoki Ishii,Tsunaki Sawada,Masaki Murata,Akinari Takao,Kazuhiro Mizukami,Ken Kinjo,Shunji Fujimori,Takahiro Uotani,Hiroki Sato,Sho Suzuki,Toshiaki Narasaka,Junnosuke Hayasaka,Tomohiro Funabiki,Yuzuru Kinjo,Akira
INTRODUCTION Length of stay (LOS) in hospital affects cost, patient quality of life, and hospital management; however, existing gastrointestinal bleeding models applicable at hospital admission have not focused on LOS. We aimed to construct a predictive model for LOS in acute lower gastrointestinal bleeding (ALGIB). METHODS We retrospectively analyzed the records of 8,547 patients emergently hospitalized
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Current Status of Diagnosis and Treatment of Colorectal Cancer in Asian Countries: A Questionnaire Survey. Digestion (IF 3.2) Pub Date : 2023-07-27 Hidenori Tanaka,Shiro Oka,Akiko Shiotani,Mitsushige Sugimoto,Hidekazu Suzuki,Yuji Naito,Osamu Handa,Tadakazu Hisamatsu,Shin Fukudo,Mitsuhiro Fujishiro,Satoshi Motoya,Naohisa Yahagi,Satoru Yamaguchi,Francis K L Chan,Sun-Young Lee,Baiwen Li,Tiing Leong Ang,Murdani Abdullah,Maria Carla Tablante,Varayu Prachayakul,Shinji Tanaka,
INTRODUCTION Diagnostic and therapeutic methods for colorectal cancer (CRC) have advanced; however, they may be inaccessible worldwide, and their widespread use is challenging. This questionnaire survey investigates the current status of diagnosis and treatment of early-stage CRC in Asian countries. METHODS Responses to the questionnaire were obtained from 213 doctors at different institutions in 8
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Symptoms Contributing to the Diagnosis of Small Bowel Tumors. Digestion (IF 3.2) Pub Date : 2023-07-12 Kozo Tsuruta,Hidetoshi Takedatsu,Shinichiro Yoshioka,Masahiro Yoshikai,Kensuke Tomiyasu,Masaru Morita,Kotaro Kuwaki,Keiichi Mitsuyama,Takumi Kawaguchi
INTRODUCTION Small bowel tumors (SBTs) are difficult to diagnose because of limited opportunities and technical difficulties in evaluating the small bowel. Asymptomatic conditions or nonspecific symptoms make SBT diagnosis more challenging. In Asia, SBTs are reported to be more frequently malignant lymphoma (ML), adenocarcinoma, and gastrointestinal stromal tumor (GIST). In this study, we examined
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Lemborexant Attenuates Regurgitation without Worsening Objective Parameters on Reflux Monitoring in Patients with Gastroesophageal Reflux Disease and Insomnia: A Single-Arm Proof-of-Concept Study. Digestion (IF 3.2) Pub Date : 2023-07-10 Yoshimasa Hoshikawa,Eri Momma,Noriyuki Kawami,Katsuhiko Iwakiri
INTRODUCTION Esophageal hypersensitivity is associated with gastroesophageal reflux disease (GERD). Since sleep disturbance causes esophageal hypersensitivity, hypnotics may ameliorate GERD. However, zolpidem prolongs esophageal acid clearance. Lemborexant is a new hypnotic with higher efficacy and fewer adverse events than zolpidem. Therefore, the present study investigated the effects of lemborexant
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Current Status of Endoscopic Full-Thickness Resection for Gastric Subepithelial Tumors: A Literature Review Over Two Decades. Digestion (IF 3.2) Pub Date : 2023-07-07 Naoya Tada,Hideki Kobara,Noriko Nishiyama,Shintaro Fujihara,Tsutomu Masaki,Noriya Uedo
BACKGROUND With the development of endoscopic technology and devices, endoscopic full-thickness resection (EFTR) has been challengingly introduced for gastric subepithelial tumors (SETs). The resection and closure strategies are under investigation. This systematic review was performed to assess the current status and limitations of EFTR for gastric SETs. SUMMARY MEDLINE was searched using the keywords
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The Association between Diverticular Rebleeding and Early-Morning Blood Pressure and Surge: A Prospective Observational Trial. Digestion (IF 3.2) Pub Date : 2023-07-05 Junya Arai,Ryota Niikura,Atsuo Yamada,Tomonori Aoki,Nobumi Suzuki,Yosuke Tsuji,Yoku Hayakawa,Takashi Kawai,Mitsuhiro Fujishiro
INTRODUCTION Colonic diverticular bleeding is the major cause of lower gastrointestinal bleeding. Hypertension is a major risk factor for diverticular rebleeding. Direct evidence of an association between actual 24-h blood pressure (BP) and rebleeding is lacking. Therefore, we analyzed the association between 24-h BP and diverticular rebleeding. METHODS We performed a prospective observational cohort
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Efficacy and Safety of Cold Snare Polypectomy of Colorectal Polyps 10-15 mm with a Hybrid Snare: A Prospective Observational Pilot Study. Digestion (IF 3.2) Pub Date : 2023-06-16 Jörg D Ulrich,Paul Rechberger,Jeannine Bachmann,Alexander Herner,Guido V Figura,Tobias Lahmer,Veit Phillip,Ulrich Mayr,Bernhard Haller,Moritz Jesinghaus,Roland M Schmid,Mohamed Abdelhafez,Christoph Schlag
INTRODUCTION Cold snare polypectomy (CSP) is a safe and effective procedure for small colorectal polyps ≤9 mm. There are only limited data regarding CSP of larger neoplastic lesions. This study evaluated the efficacy and safety of CSP for polyps between 10 and 15 mm in size. METHODS In this prospective single-arm observational pilot study, patients with a least one polyp 10-15 mm were included. These
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Long-Term Outcomes of Endoscopic Submucosal Dissection for Early Remnant Gastric Cancer: A Retrospective Multicenter Study. Digestion (IF 3.2) Pub Date : 2023-06-01 Kazunori Tsuda,Shinwa Tanaka,Tetsuya Yoshizaki,Yoshinobu Yamamoto,Takayuki Ose,Tsukasa Ishida,Yasuaki Kitamura,Daisuke Obata,Mineo Iwatate,Atsushi Ikeda,Ryusuke Ariyoshi,Fumiaki Kawara,Hiroshi Takihara,Hirofumi Abe,Toshitatsu Takao,Yoshinori Morita,Yasushi Sano,Eiji Umegaki,Hogara Nishisaki,Takashi Toyonaga,Yuzo Kodama
INTRODUCTION Favorable long-term outcomes of endoscopic submucosal dissection (ESD) for early remnant gastric cancer (ERGC) have been reported in single-center studies from advanced institutions. However, no studies have examined the long-term outcomes using a multicenter database. This study aimed to investigate the long-term outcomes of the aforementioned approach using a large multicenter database
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Cx43-Delivered miR-181b Negatively Regulates Sirt1/FOXO3a Signalling Pathway-Mediated Apoptosis on Intestinal Injury in Sepsis. Digestion (IF 3.2) Pub Date : 2023-05-25 Zhaowei Zou,Jianyang Yu,Renli Huang,Jinlong Yu
INTRODUCTION Gap junctions can transmit signals between cells, including miRNAs, leading to the amplification of adjacent cell damage. No previous study has addressed gap junctions and miRNAs in sepsis because the internal mechanism of sepsis-induced intestinal injury is complex. Therefore, we studied the relationship between connexin43 (Cx43) and miR-181b and provided a research direction for further
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Relationship between Chemotherapy-Induced Diarrhea and Intestinal Microbiome Composition. Digestion (IF 3.2) Pub Date : 2023-05-11 Yuka Kawasaki,Kazuki Kakimoto,Yasuyoshi Tanaka,Hikaru Shimizu,Koji Nishida,Keijiro Numa,Naohiko Kinoshita,Yoshihiro Tatsumi,Kei Nakazawa,Ryoji Koshiba,Yuki Hirata,Kazuhiro Ota,Naokuni Sakiyama,Tetsuji Terazawa,Toshihisa Takeuchi,Takako Miyazaki,Masahiro Goto,Haruka Yokota,Yutaka Makizaki,Yoshiki Tanaka,Shunji Nakajima,Hiroshi Ohno,Kazuhide Higuchi,Shiro Nakamura,Hiroki Nishikawa
BACKGROUND AND AIM Fluoropyrimidines (FPs) are key drugs in many chemotherapy regimens; however, recipients are often prone to diarrhea due to gastrointestinal toxicity. Disruption of the intestinal epithelial barrier function by FPs leads to dysbiosis, which may exacerbate intestinal epithelial cell damage as a secondary effect and trigger diarrhea. However, despite studies on chemotherapy-induced
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A Marked Eosinophilic Infiltration in Mucosa Could Be a Better Predictive Factor for Intractable Non-Esophageal Eosinophilic Gastrointestinal Disorders Digestion (IF 3.2) Pub Date : 2023-04-21 Shingo Ishihara, Shiko Kuribayashi, Keigo Sato, Tomohiro Kudo, Setsuo Yamazaki, Teruki Inoue, Yoichi Hazama, Kensuke Furuya, Tetsuo Nakayama, Yoko Hachisu, Kyoko Marubashi, Toshio Uraoka, Gunma Gastrointestinal Research Group
Introduction: Non-esophageal eosinophilic gastrointestinal disorders (non-EoE EGIDs) are rare, but their prevalence has recently increased. Although it has been reported that one-half of patients with non-EoE EGIDs have intractable clinical courses, their clinical features are not fully understood. Methods: This is a multicenter retrospective study in which 10 institutions in Japan participated. Clinical
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Efficacy of the Castor Oil-Filled Capsule Method as Preparation for Colon Capsule Endoscopy Digestion (IF 3.2) Pub Date : 2023-04-18 Kazuhiro Mizukami, Yoshito Inumaru, Hidetoshi Akiyama, Kensuke Fukuda, Kazuhisa Okamoto, Toshio Fujioka, Tadayoshi Okimoto, Kazunari Murakami
Background: Colon capsule endoscopy (CCE) is useful as an alternative examination for patients in whom colonoscopy is difficult. The Japanese Association for Capsule Endoscopy has published a recommended regimen for CCE using castor oil, which is becoming a standard examination method for CCE in Japan. However, castor oil has an unpleasant flavor. Therefore, patient acceptance is not good. Objectives:
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Clinical Guidelines for Diagnosis and Management of Peutz-Jeghers Syndrome in Children and Adults Digestion (IF 3.2) Pub Date : 2023-04-13 Hironori Yamamoto, Hirotsugu Sakamoto, Hideki Kumagai, Takashi Abe, Shingo Ishiguro, Keiichi Uchida, Yuko Kawasaki, Yoshihisa Saida, Yasushi Sano, Yoji Takeuchi, Masahiro Tajika, Takeshi Nakajima, Kouji Banno, Yoko Funasaka, Shinichiro Hori, Tatsuro Yamaguchi, Teruhiko Yoshida, Hideki Ishikawa, Takeo Iwama, Yasushi Okazaki, Yutaka Saito, Nariaki Matsuura, Michihiro Mutoh, Naohiro Tomita, Takashi Akiyama
Background: Peutz-Jeghers syndrome (PJS) is a rare disease characterized by the presence of hamartomatous polyposis throughout the gastrointestinal tract, except for the esophagus, along with characteristic mucocutaneous pigmentation. It is caused by germline pathogenic variants of the STK11 gene, which exhibit an autosomal dominant mode of inheritance. Some patients with PJS develop gastrointestinal
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Efficacy and Safety of Vonoprazan and Amoxicillin Dual Therapy for Helicobacter pylori Eradication: A Systematic Review and Meta-Analysis Digestion (IF 3.2) Pub Date : 2023-04-04 Wen-Lin Zhang, Bo-Shen Lin, Yue-Yue Li, Yu-Ming Ding, Zhong-Xue Han, Rui Ji
Introduction: Vonoprazan, a novel potassium-competitive acid blocker, has a strong acid suppression effect and potent efficacy in acid-associated diseases, including Helicobacter pylori eradication. We performed a systematic review and meta-analysis to investigate the efficacy and safety of vonoprazan/amoxicillin dual therapy for H. pylori eradication. Methods: We conducted a systematic literature
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Characteristics of Gastric Stasis due to Deformation after Endoscopic Submucosal Dissection in the Lower Part of the Stomach Digestion (IF 3.2) Pub Date : 2023-03-22 Hiroshi Takayama, Takashi Toyonaga, Tetsuya Yoshizaki, Hirofumi Abe, Tatsuya Nakai, Chise Ueda, Satoshi Urakami, Hidetoshi Kaku, Yusaku Shimamoto, Kei Matsumoto, Kazunori Tsuda, Hiroya Sakaguchi, Shinichi Baba, Hiroshi Takihara, Nobuaki Ikezawa, Shinwa Tanaka, Madoka Takao, Toshitatsu Takao, Yoshinori Morita, Yuzo Kodama
Introduction: Gastric stasis due to deformation occurs after endoscopic submucosal dissection in the lower part of the stomach. Endoscopic balloon dilation can improve gastric stasis due to stenosis; however, endoscopic balloon dilation cannot improve gastric stasis due to deformation. Furthermore, the characteristics of gastric stasis due to deformation are unknown. This study aimed to evaluate the
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Risk Factors for Ceftriaxone-Associated Pseudolithiasis in Adults Digestion (IF 3.2) Pub Date : 2023-03-10 Akihiro Matsumi, Takeshi Tomoda, Hiroyuki Terasawa, Yuki Fujii, Tatsuhiro Yamazaki, Daisuke Uchida, Kazuyuki Matsumoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hironari Kato
Introduction: Ceftriaxone (CTRX) is known to occasionally cause pseudolithiasis. This condition is often observed in children; however, few studies have reported the incidence and risk factors for CTRX-associated pseudolithiasis. Methods: In this single-center retrospective study, we investigated the incidence of and risk factors for CTRX-associated pseudolithiasis in adults. All patients underwent
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Clinical Features Focusing on Extraintestinal Manifestations in Japanese Patients with Inflammatory Bowel Diseases: Far East 1000 Digestion (IF 3.2) Pub Date : 2023-03-09 Yuki Ohta, Takashi Taida, Jun Kato, Sadahisa Ogasawara, Yuhei Oyama, Yukiyo Mamiya, Hayato Nakazawa, Ryosuke Horio, Chihiro Goto, Satsuki Takahashi, Akane Kurosugi, Michiko Sonoda, Wataru Shiratori, Tatsuya Kaneko, Yuya Yokoyama, Naoki Akizue, Hideaki Ishigami, Hirotaka Koseki, Kenichiro Okimoto, Keiko Saito, Masaya Saito, Tomoaki Matsumura, Tomoo Nakagawa, Yoshio Masuya, Yoshihiro Fukuda, Yoshio Kitsukawa
Background: Patients with inflammatory bowel diseases (IBD) can develop extraintestinal manifestations (EIMs) during the disease course, which sometimes impact their quality of life. Objectives: This study aimed to clarify the prevalence and types of EIMs using a hospital-based IBD cohort in Japan. Methods: A patient cohort with IBD was established in 2019, as participated by 15 hospitals in Chiba
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Secondary Sclerosing Cholangitis due to Severe COVID-19: An Emerging Disease Entity? Digestion (IF 3.2) Pub Date : 2023-03-08 Michael Seifert, Guntje Kneiseler, Alexander Dechene
Introduction: Coronavirus disease 2019 (COVID-19) can lead to many extrapulmonary manifestations. In this case series, we report on 7 patients developing secondary sclerosing cholangitis (SSC) after severe COVID-19 with intensive care treatment. Methods: Between March 2020 and November 2021, 544 patient cases with cholangitis treated at a German tertiary care centre were screened for SSC. Patients
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Saliva Secretion Is Significantly Lower in Female Patients with Mild Reflux Esophagitis than in Female Healthy Controls Digestion (IF 3.2) Pub Date : 2023-02-07 Eri Momma, Mai Koeda, Yoshimasa Hoshikawa, Tomohide Tanabe, Shintaro Hoshino, Yuichi Kitasako, Noriyuki Kawami, Katsuhiko Iwakiri
Introduction: Saliva secretion is significantly lower in patients with mild reflux esophagitis than in healthy controls. A previous study on healthy controls showed that stimulated saliva secretion was lower in females than in males. Saliva secretion may be lower in female patients with mild reflux esophagitis than in male patients. Therefore, the present study investigated sex differences in saliva
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Impact of Transarterial Chemoembolization or Hepatic Artery Infusion Chemotherapy on Liver Function after Hepatocellular Carcinoma Resection: An Observational Study Digestion (IF 3.2) Pub Date : 2023-02-06
Introduction: Liver surgery leads to a high degree of heterogeneity in the prognosis of hepatocellular carcinoma (HCC) patients. However, most previous studies focused on the postoperative therapeutic effects of other treatments, with relatively few studies on the impacts on liver function. This study investigated the impact of transarterial chemoembolization (TACE) and hepatic artery infusion chemotherapy
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Long-Term Clinical Course after Successful Initial Treatment in Patients with Mild Erosive Esophagitis: A Prospective Follow-Up Study Digestion (IF 3.2) Pub Date : 2023-01-30 Hideharu Okanobu, Tomohiko Kohno, Kazuki Boda, Hidenori Ochi, Yoshinari Furukawa
Introduction: This study aimed to investigate the clinical course of patients with healed mild erosive esophagitis and clarify the predictive factors for continuous treatment. Method: Fifty-one patients with mild erosive esophagitis who confirmed mucosal healing by endoscopy after initial treatment with vonoprazan (VPZ) were enrolled. The patients continued subsequent treatment of their choice: maintenance
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Erratum Digestion (IF 3.2) Pub Date : 2023-01-25 V. Ellenrieder, A. Andoh, Volker Ellenrieder, Silke Cameron, Ute König, Yasuhisa Shinomura, Christoph Beglinger, Toshiro Sugiyama, Gerhard Rogler, Michel Delvaux, Roland M. Schmid, Thomas Seufferlein, Nisar Malek, Alexander Otto König, Arndt Vogel, Masao Tanaka, Atsushi Nakajima, Kazuhide Higuchi, Patrick Johannes Michl, A. Andoh, Yoshikazu Kinoshita, Y. Sasaki, T. Takayama, Jochen Gaedcke, Andreas
Digestion
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Examination on Factors Affecting Symptom Change after Drug Withdrawal in Patients with Mild Erosive Gastroesophageal Reflux Disease Undergoing Symptom-Controlled Maintenance Therapy with Acid-Secretion Inhibition Drugs Digestion (IF 3.2) Pub Date : 2023-01-17
Introduction: In patients with gastroesophageal reflux disease (GERD) on maintenance therapy with acid-suppressive drugs, it is not clear what background factors allow patients to discontinue the drugs. The aims of this study were to examine the relationship of the changes in the frequency and severity of gastrointestinal symptoms after discontinuation of acid-secretion inhibitors for erosive GERD
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A Multicenter Prospective Validation Study on Selective Endoscopic Resection of Sessile Serrated Lesions Using Magnifying Colonoscopy in Clinical Practice Digestion (IF 3.2) Pub Date : 2023-01-17 Daizen Hirata, Hiroshi Kashida, Tsuguhiro Matsumoto, Chikara Ebisutani, Akira Teramoto, Mineo Iwatate, Santa Hattori, Mikio Fujita, Wataru Sano, Yoriaki Komeda, Yasushi Sano, Yoshitaka Murakami, Masatoshi Kudo
Introduction: Sessile serrated lesions (SSLs) have malignant potential for colorectal cancer in the serrated pathway. Selective endoscopic resection of SSLs would reduce medical costs and procedure-related accidents, but the accurate endoscopic differentiation of SSLs from hyperplastic polyps (HPs) is challenging. To explore the differential diagnostic performance of magnifying colonoscopy in distinguishing
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Examination on Factors Affecting Symptom Change after Drug Withdrawal in Patients with Mild Erosive Gastroesophageal Reflux Disease Undergoing Symptom-Controlled Maintenance Therapy with Acid-Secretion Inhibition Drugs. Digestion (IF 3.2) Pub Date : 2023-01-17 Hironori Tanaka,Toshihisa Takeuchi,Shinya Nishida,Hitosi Hongo,Michiaki Takii,Takeshi Higashino,Makoto Sanomura,Hirota Miyazaki,Masahiro Hoshimoto,Tsuguhiro Kimura,Masahiro Sakaguchi,Takashi Abe,Akitoshi Hakoda,Noriaki Sugawara,Taro Iwatsubo,Shinpei Kawaguchi,Kazuhiro Ota,Yuichi Kojima,Kazuhide Higuchi
INTRODUCTION In patients with gastroesophageal reflux disease (GERD) on maintenance therapy with acid-suppressive drugs, it is not clear what background factors allow patients to discontinue the drugs. The aims of this study were to examine the relationship of the changes in the frequency and severity of gastrointestinal symptoms after discontinuation of acid-secretion inhibitors for erosive GERD (eGERD)
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Analysis of Circulating DNA to Assess Prognoses for Metastatic Colorectal Cancer Patients Treated with Regorafenib Dose-Escalation Therapy: A Retrospective, Exploratory Analysis of the RECC Trial Digestion (IF 3.2) Pub Date : 2023-01-16 Ryo Ohta, Takeshi Yamada, Masato Nakamura, Masanobu Enomoto, Makoto Takahashi, Hajime Yokomizo, Chihiro Kosugi, Kei Ishimaru, Hiromichi Sonoda, Hidekazu Kuramochi, Yoichiro Yoshida, Shinji Furuya, Keiji Hirata, Hiroshi Yoshida, Keijiro Nozawa, Yojiro Hashiguchi, Hideyuki Ishida, Keiji Koda, Kenji Katsumata, Kazuhiro Sakamoto
Introduction: Regorafenib is a multi-kinase inhibitor approved for patients with metastatic colorectal cancer (mCRC) who were previously treated with standard therapies. A few reports showed the impact of KRAS mutation on therapeutic efficacy of regorafenib. Only one study reported poor prognoses for patients treated with regorafenib who had large amounts of circulating cell-free DNA (cfDNA). In the
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The Single Nucleotide Polymorphisms rs4143370 and rs34904192 in MIR155HG Were Associated with Esophageal Cancer Risk in the Chinese Han Population Digestion (IF 3.2) Pub Date : 2023-01-16 Zhuoqi Jia, Weiru Zhou, Jing Liang, Guangjian Zhang, Junke Fu, Xuejun Sun
Introduction: MIR155HG has been found to play an important role in malignant tumors, but little research has been done on its association with esophageal cancer (ESCC). The aim of this study was to investigate the relationship between MIR155HG polymorphisms and ESCC susceptibility in the Chinese Han population. Methods: 511 ESCC patients and 487 healthy controls were selected for this study. All subjects
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Endoscopic Ligation with O-Ring Closure for Mucosal Defects after Rectal Endoscopic Submucosal Dissection: A Feasibility Study (with Video) Digestion (IF 3.2) Pub Date : 2023-01-11 Naoya Tada, Hideki Kobara, Noriko Nishiyama, Kazuhiro Kozuka, Takanori Matsui, Taiga Chiyo, Nobuya Kobayashi, Tatsuo Yachida, Shintaro Fujihara, Tsutomu Masaki
Introduction: Mucosal defect closure after colorectal endoscopic submucosal dissection (ESD) may prevent post-ESD adverse events. Delayed bleeding is a particular concern in the rectum due to the presence of numerous blood vessels. However, rectal defect closure often fails due to the thick rectal wall. This study aimed to examine the feasibility of our newly developed endoscopic ligation with O-ring
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Comparison of Efficacy and Safety between Endoscopic Retrograde Cholangiopancreatography and Percutaneous Transhepatic Cholangial Drainage for the Treatment of Malignant Obstructive Jaundice: A Systematic Review and Meta-Analysis Digestion (IF 3.2) Pub Date : 2023-01-06 Liwei Pang, Shuodong Wu, Jing Kong
Background: At present, endoscopic retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic cholangial drainage (PTCD) are frequently used for reducing malignant obstructive jaundice (MOJ). However, it is controversial as to which method is superior in terms of efficacy and safety. Objectives: The aim of this study was to compare the safety, feasibility, and clinical benefits of ERCP
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Diagnostic Performance of Endocytoscopy for Esophageal Eosinophilia Digestion (IF 3.2) Pub Date : 2023-01-05 Emiko Hida, Koichi Muroi, Naomi Kakushima, Satoshi Furune, Eri Ishikawa, Yasuyuki Mizutani, Tsunaki Sawada, Maeda Keiko, Takeshi Yamamura, Takuya Ishikawa, Kazuhiro Furukawa, Eizaburo Ohno, Masanao Nakamura, Kazuki Nishida, Mitsuhiro Fujishiro, Hiroki Kawashima
Introduction: Eosinophils in the esophageal epithelium are unevenly distributed in eosinophilic esophagitis (EoE). Esophageal eosinophilia (EE) may be observable by endocytoscopy (EC). This study aimed to evaluate the diagnostic performance of EC for the diagnosis of EE. Methods: A total of 33 EoE patients underwent EC with methylene blue staining from March 2020 to April 2021. A total of 194 EC images
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Relapse and Need for Extended Immunosuppression: Novel Features of Drug-Induced Autoimmune Hepatitis Digestion (IF 3.2) Pub Date : 2023-01-05 Sabine Weber, Alexander L. Gerbes
Background: Drug-induced autoimmune hepatitis (DI-AIH) has been proposed as a distinct phenotype of drug-induced liver injury (DILI), and frequently has been associated with specific drugs, such as minocycline and nitrofurantoin. However, no clear definition of DI-AIH has been established thus far. Objectives: We aimed to identify features distinguishing DI-AIH from DILI and idiopathic autoimmune hepatitis
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Clinical Evaluation of Computer-Aided Colorectal Neoplasia Detection Using a Novel Endoscopic Artificial Intelligence: A Single-Center Randomized Controlled Trial Digestion (IF 3.2) Pub Date : 2023-01-04 Hirotaka Nakashima, Naoko Kitazawa, Chika Fukuyama, Hiroshi Kawachi, Hiroshi Kawahira, Kumiko Momma, Nobuhiro Sakaki
Introduction: Computer-aided diagnostic systems are emerging in the field of gastrointestinal endoscopy. In this study, we assessed the clinical performance of the computer-aided detection (CADe) of colonic adenomas using a new endoscopic artificial intelligence system. Methods: This was a single-center prospective randomized study including 415 participants allocated into the CADe group (n = 207)
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Proton Pump Inhibitor Treatment Has Little Effects on Secretion of Saliva in Patients with Proton Pump Inhibitor-Responsive Mild Reflux Esophagitis and Non-Erosive Reflux Disease Digestion (IF 3.2) Pub Date : 2022-12-29
Introduction: The secretion of saliva, which is triggered by acid reflux into the esophagus via the esophagosalivary reflex, plays a crucial role in the defensive mechanisms of the esophagus. The volume of saliva secreted in patients with gastroesophageal reflux disease (GERD) is reduced. However, the effects of proton pump inhibitors (PPI) on the secretion of saliva have rarely been reported. Therefore
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Proton Pump Inhibitor Treatment Has Little Effects on Secretion of Saliva in Patients with Proton Pump Inhibitor-Responsive Mild Reflux Esophagitis and Non-Erosive Reflux Disease. Digestion (IF 3.2) Pub Date : 2022-12-29 Yoshimasa Hoshikawa,Eri Momma,Shintaro Hoshino,Noriyuki Kawami,Yuichi Kitasako,Masaomi Ikeda,Katsuhiko Iwakiri
INTRODUCTION The secretion of saliva, which is triggered by acid reflux into the esophagus via the esophagosalivary reflex, plays a crucial role in the defensive mechanisms of the esophagus. The volume of saliva secreted in patients with gastroesophageal reflux disease (GERD) is reduced. However, the effects of proton pump inhibitors (PPI) on the secretion of saliva have rarely been reported. Therefore
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Identification of Biomarkers Associated with the Prognoses of Colorectal Cancer Patients Digestion (IF 3.2) Pub Date : 2022-12-28
Introduction: Colorectal cancer (CRC) is a common cancer. As metastasis and recurrence are main causes of CRC death, it is of great significance to find prognostic biomarkers. Methods: Data related to CRC were collected from GEO database. The patients were grouped based on clinical information, and the differentially expressed genes (DEGs) were obtained by differential analysis. GO and KEGG pathway
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Erratum Digestion (IF 3.2) Pub Date : 2022-12-23 V. Ellenrieder, A. Andoh, Volker Ellenrieder, Silke Cameron, Ute König, Yasuhisa Shinomura, Christoph Beglinger, Toshiro Sugiyama, Gerhard Rogler, Michel Delvaux, Roland M. Schmid, Thomas Seufferlein, Nisar Malek, Alexander Otto König, Arndt Vogel, Masao Tanaka, Atsushi Nakajima, Kazuhide Higuchi, Patrick Johannes Michl, A. Andoh, Yoshikazu Kinoshita, Y. Sasaki, T. Takayama, Jochen Gaedcke, Andreas
Digestion
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Association between Mucosal Healing and Lipid Profiles in Patients with Ulcerative Colitis: A Cross-Sectional Study Digestion (IF 3.2) Pub Date : 2022-12-09 Sen Yagi, Shinya Furukawa, Teruki Miyake, Kana Shiraishi, Kazuhiro Tange, Yu Hashimoto, Shogo Kitahata, Tomoyuki Ninomiya, Seiyuu Suzuki, Naozumi Shibata, Hidehiro Murakami, Katsuhisa Ohashi, Hideomi Tomida, Yasunori Yamamoto, Eiji Takeshita, Yoshio Ikeda, Yoichi Hiasa
Introduction: Recent meta-analysis showed that ulcerative colitis (UC) is a risk factor for cardiovascular disease (CVD). Dyslipidemia is a well-established risk factor for CVD. However, evidence regarding inflammatory bowel disease (IBD), including UC and lipid profiles, is limited. Additionally, no study has assessed the association between endoscopic activity and lipid profiles in patients with
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Chronological Changes in Mucosal Deformity by Endoscopic Suturing after Gastric Endoscopic Submucosal Dissection: A Multicenter Retrospective Analysis Digestion (IF 3.2) Pub Date : 2022-12-07 Kazutoshi Higuchi, Osamu Goto, Akiko Takahashi, Teppei Akimoto, Tsugumi Habu, Yumiko Ishikawa, Kumiko Kirita, Eriko Koizumi, Hiroto Noda, Takeshi Onda, Jun Omori, Naohiko Akimoto, Mitsuru Kaise, Naohisa Yahagi, Tsuneo Oyama, Katsuhiko Iwakiri
Introduction: Endoscopic suturing of a mucosal defect is expected to prevent postoperative bleeding after endoscopic submucosal dissection (ESD). Endoscopic suturing causes mucosal deformity, which may interfere with endoscopic surveillance thereafter. We retrospectively investigated long-term chronological changes in mucosal suturing by endoscopic suturing. Methods: Forty-three patients who underwent
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Effects of Sprayable, Highly Adhesive Hydrophobized Gelatin Microparticles on Endoscopic Submucosal Dissection: A Swine Model Digestion (IF 3.2) Pub Date : 2022-12-05 Masayuki Kabayama, Fumisato Sasaki, Maeda Hidehito, Yusuke Fujino, Hiroki Yano, Akihito Tanaka, Shiho Arima, Shiroh Tanoue, Shinichi Hashimoto, Shuji Kanmura, Hiromi Hirade, Akihiro Nishiguchi, Tetsushi Taguchi, Akio Ido
Introduction: Sprayable wound dressings containing hydrophobized microparticles (hMPs) are characterized by strong adhesiveness. We examined the effect of hMPs derived from Alaska pollock gelatin on endoscopic submucosal dissection (ESD) ulcers. Methods: (1) In an in vivo model of miniature swine gastric ESD, gastric ulcers were created by ESD and then sprayed with hMPs or untreated followed by microscopic
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Natural History of Small Gastric Subepithelial Lesions Less than 20 mm: A Multicenter Retrospective Observational Study (NUTSHELL20 Study) Digestion (IF 3.2) Pub Date : 2022-12-05 Keiichiro Abe, Keiichi Tominaga, Akira Yamamiya, Yasunori Inaba, Akira Kanamori, Masayuki Kondo, Tsunehiro Suzuki, Hidetaka Watanabe, Masaki Kawano, Takashi Sato, Naoto Yoshitake, Tsuneo Ohwada, Maki Konno, Kazunobu Hanatsuka, Hironori Masuyama, Kenichi Goda, Yasuo Haruyama, Atsushi Irisawa, NUTSHELL20 Study group
Background and Aim: Small gastric subepithelial lesions (SELs) are sometimes encountered in daily esophagogastroduodenoscopy (EGD) practice, but whether once-annual or twice-annual endoscopy can provide sufficient follow-up remains unclear. Because follow-up based on small-SEL characteristics is important, this study clarified the natural history of gastric SELs less than 20 mm. Methods: This retrospective
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