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Effect of Suboptimal Disease Control on Patient Quality of Life: Real-World Data from the Observational IBD-PODCAST Canada Trial Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-16 Jesse Siffledeen, Sunny Singh, Scott M. Shulman, John Igoe, Tobias Heatta-Speicher, Claudia Leitner, Chia Hui Chung, Laura Targownik
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Low-Dose Aspirin Use Does Not Increase Disease Activity in Pregnant Patients with Inflammatory Bowel Disease Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-16
Abstract Background The adverse effects of non-steroidal anti-inflammatory (NSAID) drugs on the gastrointestinal system are well recognized, but the effect of NSAID use on disease activity patients with inflammatory bowel disease (IBD) remains unresolved. Low-dose aspirin (LDA) is recommended for all pregnant patients with risk factors for developing preeclampsia, including autoimmune conditions. As
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Comparative Analysis of Enbloc or Piecemeal Removal After Enbloc Resection of Gastrointestinal Stromal Tumors Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-14 Jing-wen Zhang, Chang-qing Guo, Shan-shan Zhu, Ghulam Nabi, Nan Dai, Xiao-yu Wan, Ping Liu, Fang-bin Zhang, Yang Fu, Xin-gung Cao
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Impact of COVID-19 Treatment on Real-World Outcomes in Inflammatory Bowel Disease Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-11 Laura C. Sahyoun, Jonathan Fetene, Chandler McMillan, Petr Protiva, Badr Al Bawardy, Jill K. J. Gaidos, Deborah Proctor
Background While there are multiple safe and effective agents for COVID-19 treatment, their impact in inflammatory bowel disease (IBD) remains uncertain. Aims Our objective was to assess the effects of these therapies on both IBD and COVID outcomes. Methods A single-center retrospective study of adult patients with IBD who contracted COVID-19 between 12/2020 and 11/2022 was performed. Patients were
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Interleukin-22 Alleviates Caerulein-Induced Acute Pancreatitis by Activating AKT/mTOR Pathway Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-11 Xinjuan Fu, Zhigang Xiu, Qianqian Xu, Rui Yue, Hongwei Xu
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Like a Rolling (Gall)Stone: Optimal Treatment of Gallstone Obstruction of the Sigmoid Colon Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-11
Abstract Background Sigmoid gallstone ileus is a rare complication of cholelithiasis, accounting for 1–4% of all cases of large-bowel obstruction. This is a highly morbid, and often fatal, condition due to its challenging diagnosis and late presentation. Case presentation We report a case of a 90-year-old woman admitted to Emergency Department with abdominal pain and large-bowel obstruction due to
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Hospital-Level Care at Home for Patients with Cirrhosis Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-11 Olivia Kahn-Boesel, Henry Mitchell, Lucinda Li, Ennie Zhu, Areej El-Jawahri, David Levine, Nneka N. Ufere
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Assessment of the Learning Curve for a Single-Use Disposable Duodenoscope Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-11
Abstract Background and Aims In response to documented duodenoscope-related infectious outbreaks of multidrug-resistant organisms, the Food and Drug Administration has recommended a transition to duodenoscopes with innovative designs, including duodenoscopes with disposable components or fully disposable duodenoscopes. We aim to characterize the learning curve (LC) for a single-use disposable duodenoscope
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Successful Treatment of Recurrent Clostridioides difficile Infection Using a Novel, Drinkable, Oral Formulation of Fecal Microbiota Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-08 Michael J. Sadowsky, Michael Matson, Prince P. Mathai, Maradi Pho, Christopher Staley, Clayton Evert, Melissa Weldy, Alexander Khoruts
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Food-Related Quality of Life and Its Predictors in Inflammatory Bowel Disease Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-08 Raquel Oliveira, Viviana Martins, Helena Tavares de Sousa, Joana Roseira
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Bile Culture May Guide Antibiotic Stewardship in Acute Bacterial Cholangitis Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-08 John Titus George, Ajith Thomas, Rajeeb Jaleel, G. Jackwin Sam Paul, Anoop John, Reuben Thomas Kurien, Sudipta Dhar Chowdhury, Ebby George Simon, A. J. Joseph, Amit Kumar Dutta
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Development and Validation of Case-Finding Algorithms to Identify Pancreatic Cancer in the Veterans Health Administration Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-07 Catherine Mezzacappa, Navid Rahimi Larki, Melissa Skanderson, Lesley S. Park, Cynthia Brandt, Ronald G. Hauser, Amy Justice, Yu-Xiao Yang, Louise Wang
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Healthcare Resource Utilization and Goals of Care Discussions in Patients with Cirrhosis and Acute Kidney Injury Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-07
Abstract Background Patients with cirrhosis and acute kidney injury (AKI) are critically ill and have high health care resource utilization (HCRU). The impact and timing of goals of care discussions on HCRU are not well described. Methods 221 patients enrolled in a prospective cohort study of patients admitted with AKI and cirrhosis were reviewed. Documentation and timing of a goals of care discussions
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Development of a Serum-Based MicroRNA Signature for Early Detection of Pancreatic Cancer: A Multicenter Cohort Study Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-07 Jing Huang, Ge Gao, Yang Ge, Jianzhou Liu, Hongtu Cui, Ren Zheng, Jialin Wang, Si Wang, Vay Liang Go, Shen Hu, Yefu Liu, Minwei Yang, Yongwei Sun, Dong Shang, Yantao Tian, Zhigang Zhang, Zhongyuan Xiang, Hongyang Wang, Junchao Guo, Gary Guishan Xiao
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Endoscopic Resection for Colonic Angiomas Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06 Wei Yang, Binbin Gu, Dan Li, Jiahui Wang, Jinshun Zhang
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Comet Tail Artifacts in Pseudocyst on Endoscopic Ultrasound Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06 Surinder Singh Rana, Rajesh Gupta
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The Future is Bright (Red) for Hemostasis of Peptic Ulcers Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06 Kenneth W. Hung
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Ulcer Bleeding in the United States: Epidemiology, Treatment Success, and Resource Utilization Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06 Hata Mujadzic, Shayan Noorani, Philip J. Riddle, Yichen Wang, Gracelyn Metts, Tania Yacu, Marwan S. Abougergi
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Intestinal Rehabilitation Program for Adult Patients with Intestinal Failure: A 20-Year Analysis of Outcomes in the Single-Center Experience at a Tertiary Hospital Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06
Abstract Background & Aims The intestinal rehabilitation program (IRP) is a specialized approach to managing patients with intestinal failure (IF). The goal of IRP is to reduce the patient’s dependence on parenteral nutrition by optimizing nutrition intake while minimizing the risk of complications and providing individualized medical and surgical treatment. We aimed to provide a thorough overview
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Gastrointestinal Characteristics of Constipation from the Perspectives of Microbiome and Metabolome Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06 Huimin Wang, Di Zhao, Senyan Wang, Huanle Liu, Sijun Zhao, Zhenyu Li, Xuemei Qin, Xiaojie Liu
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Kinesin Family Member-18A (KIF18A) Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06 Jihua Ren, Xinyan Yao, Minli Yang, Shengtao Cheng, Daiqing Wu, Kexin Xu, Ranran Li, Han Zhang, Dapeng Zhang
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Factors Underlying the Difference in Response to Fecal Microbiota Transplantation Between IBS Patients with Severe and Moderate Symptoms Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06
Abstract Background Previous studies showed that patients with Severe IBS respond better to fecal microbiota transplantation (FMT) than do those with Moderate IBS. Aims The present study aimed to determine the effects of the transplant dose, route of administering it and repeating FMT on this difference. Methods This study included 186 patients with IBS randomized 1:1:1 into groups with a 90-g transplant
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Cholecystokinin-Induced Duodenogastric Bile Reflux Increases the Severity of Indomethacin-Induced Gastric Antral Ulcers in Re-fed Mice Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-06 Hiroshi Satoh, Yasutada Akiba, Tetsuro Urushidani, Jonathan D. Kaunitz
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A Dedicated Celiac Disease Program Improves Celiac Quality Care Metrics and Short-Term Outcomes in Real Life Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-05
Abstract Background and Aims Dedicated multidisciplinary programs in gastroenterology are emerging with the goal to improve care. There is little information about the effects of a celiac disease program on disease-related quality care metrics and outcomes. We aimed to compare quality care metrics, symptom resolution, and serological response among patients diagnosed and treated in a celiac disease
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Ameliorative Effects of Larazotide Acetate on Intestinal Permeability and Bacterial Translocation in Acute Pancreatitis Model in Rats Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-05 Doğu Karahan, Muhsin Murat Muhip Harputluoglu, Mehmet Gul, Ayten Gunduz, Fatma Ozyalin, Feyza İnceoğlu, Deniz Tikici, İsmet Yılmaz, Basri Satilmis
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Insulin Resistance/Sensitivity Measures as Screening Indicators of Metabolic-Associated Fatty Liver Disease and Liver Fibrosis Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-04 Mohammad E. Khamseh, Mojtaba Malek, Soodeh Jahangiri, Sohrab Nobarani, Azita Hekmatdoost, Marieh Salavatizadeh, Samira Soltanieh, Haleh Chehrehgosha, Hoda Taheri, Zeinab Montazeri, Fereshteh Attaran, Faramarz Ismail-Beigi, Fariba Alaei-Shahmiri
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Single Versus Second Observer vs Artificial Intelligence to Increase the ADENOMA Detection Rate of Colonoscopy—A Network Analysis Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-04 Manesh Kumar Gangwani, Hossein Haghbin, Rizwan Ishtiaq, Fariha Hasan, Julia Dillard, Fouad Jabbar, Dushyant Singh Dahiya, Hassam Ali, Shaharyar Salim, Wade Lee-Smith, Amir Sohail, Sumant Inamdar, Muhammad Aziz, Benjamin Hart
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Contribution of High Body Mass Index to the Global Burden of Esophageal Cancer: A Population-Based Study from 1990 to 2019 Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-03 Wenjie Li, Wei Wang
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Successful Removal of Gallbladder Stones Under Direct Visualization of Single-Operator Peroral Cholangioscopy (with Video) Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-02 Hai Yun Shi, Min Si Zhou, Chun Tao Liu, Ming Ji, Jing Wu
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Relationship of Age and Gender to Motility Test Results and Symptoms in Patients with Chronic Constipation Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-03-02 George Triadafilopoulos, Jerry D. Gardner
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Electroacupuncture Improving Intestinal Barrier Function in Rats with Irritable Bowel Syndrome Through Regulating Aquaporins Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-29 Xueling Kang, Honglin Zhang, Xiaying Li, Kai Zhang, Zhansheng Huang, Yuanyuan Li, Xiaoxuan Ren, Yemao Chai
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Cold Snare Polypectomy With or Without Submucosal Injection for Endoscopic Resection of Colorectal Polyps: A Meta-Analysis of Randomized Controlled Trials Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-28 Xiu-He Lv, Tong Liu, Zi-Jing Wang, Tao Gan, Jin-Lin Yang
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Pediatric ERCP: Evolving into an Outpatient Procedure Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-28 Monique T. Barakat, Andrew Yong-Jueen Liman, Roberto Gugig
Background While most adult ERCPs are performed on an outpatient basis, pediatric ERCPs are typically performed on an inpatient basis, or with ERCP followed by at least one night inpatient admission. We have begun performing a substantial proportion of our pediatric ERCPs on an outpatient basis, using our clinical judgment to guide the decision process. In the present study, we compare patient characteristics
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Upadacitinib as Rescue Therapy for the Treatment of Acute Severe Colitis in an Acute Care Setting Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-28
Abstract Background Inflammatory bowel disease is a chronic, relapsing, and remitting inflammatory disorder that despite advances in medical therapy often requires hospitalization for treatment of acute flares with intravenous corticosteroids. Many patients will not respond to corticosteroids and require infliximab or cyclosporine as rescue therapy. If medical therapy fails, definitive surgical management
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Endoscopic Ultrasound-Guided Pancreatic Pseudocyst Drainage Using a Novel Dilation Device with Double Guidewire Insertion Function (with Video) Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-28 Takeshi Ogura, Saori Ueno, Nobu Nishioka, Atsushi Okuda, Hiroki Nishikawa
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Nomogram for Predicting the Risk of Complications after Endoscopic Foreign Body Removal from the Adult Upper Gastrointestinal Tract Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-28 Zhe Chen, Minhao Yin, Peichen Xia, Xu Han, Hong Zhu
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Amiodarone and Dronedarone Causes Liver Injury with Distinctly Different Clinical Presentations Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-28
Abstract Objective To describe hepatotoxicity due to amiodarone and dronedarone from the DILIN and the US FDA’s surveillance database. Methods Hepatotoxicity due to amiodarone and dronedarone enrolled in the U.S. Drug Induced Liver Injury Network (DILIN) from 2004 to 2020 are described. Dronedarone hepatotoxicity cases associated with liver biopsy results were obtained from the FDA Adverse Event Reporting
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Bariatric Nutritional Intervention in Obese Patients with Compensated Liver Cirrhosis: A Four-Year Prospective Study Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-27
Abstract Background Obesity and liver cirrhosis represent significant health challenges, often leading to various complications. Aims This prospective study aimed to investigate the impact of a four-year bariatric intervention, focusing on adherence to the Mediterranean Diet, on anthropometric, hematologic, and biochemical parameters in obese patients with compensated liver cirrhosis. Additionally
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Intestinal Microbiota Modulates the Antitumor Effect of Oncolytic Virus Vaccines in Colorectal Cancer Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-24 Xia Chen, Guanjun Wang, Ling Qin, Bing Hu, Jun Li
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Healthcare Utilization Patterns: Irritable Bowel Syndrome, Inflammatory Bowel Disease, and Gastroesophageal Reflux Disease Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-24 Natasha Koloski, Ayesha Shah, Iain Kaan, Ronen Ben Jacob, Nicholas J. Talley, Michael P. Jones, Gerald Holtmann
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Circular RNA CircSLC22A23 Promotes Gastric Cancer Progression by Activating HNRNPU Expression Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-24 Xinxin Wu, Chunli Cao, Zhe Li, Yaoyao Xie, Shuangshuang Zhang, Weiliang Sun, Junming Guo
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Epidemiology and Socioeconomic Impact of Pancreatic Cancer: An Analysis of the Global Burden of Disease Study 1990–2019 Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-21 Daryl Ramai, Eric R. Smith, Yichen Wang, Yuting Huang, Itegbemie Obaitan, Saurabh Chandan, Banreet Dhindsa, Apostolis Papaefthymiou, John D. Morris
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Gastrointestinal Bleeding Was Diagnosed as Small Intestinal Metastasis of Hepatocellular Carcinoma by Double-Balloon Enteroscopy Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-21 Xiaohan Zhao, Xinrui Guo, Ying Zhao, Yanbo Yu
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Early Graft Failure After Living-Donor Liver Transplant Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-21 Ahmad Anouti, Moustafa Al Hariri, Lisa B. VanWagner, William M. Lee, Arjmand Mufti, Mark Pedersen, Jigesh Shah, Steven Hanish, Parsia A. Vagefi, Thomas G. Cotter, Madhukar S. Patel
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Concurrent Arterial and Venous Thromboses in Ulcerative Colitis: A Complex Case of Multiorgan Involvement Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-20 Wenyu Su, Xiao Liang, Hong Lu, Jin Zhang, Jing-Yuan Fang
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HSK3486 Inhibits Colorectal Cancer Growth by Promoting Oxidative Stress and ATPase Inhibitory Factor 1 Activation Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-20
Abstract Background HSK3486 (ciprofol), a new candidate drug similar to propofol, exerts sedative and hypnotic effects through gamma-aminobutyric acid type A receptors; however, its potential role in colorectal cancer is currently unknown. Aims This study aimed to evaluate the effects of HSK3486 on colorectal cancer cell proliferation. Methods Imaging was performed to detect reactive oxygen species
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Effect of Concurrent Metabolic Dysfunction-Associated Steatotic Liver Disease on Serial Non-invasive Fibrosis Markers in Chronic Hepatitis B Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-20 Danny Con, Steven Tu, Daniel Clayton-Chubb, John S. Lubel, Amanda J. Nicoll, Rohit Sawhney, Stephen Bloom
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Long Non-coding RNA X-Inactive Specific Transcript Promotes Esophageal Squamous Cell Carcinoma Progression via the MicroRNA 34a/Zinc Finger E-box–Binding Homeobox 1 Pathway Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-16 Bin Guo, Ming He, Minting Ma, Ziqiang Tian, Jing Jin, Guo Tian
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Easy and Feasible Closure for a Large Perforation After Gastric Full-Thickness Resection: Clipping Method with Symmetrical Anchors Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-16 Jianan Mao, Guangxin Wu, Dan Liu
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The Association of Metabolic Risk Factors with Advanced Adenomas in Hispanic Patients Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-16 Robert Tamai, Lillian Dawit, Patrick Lee, Okeefe L. Simmons, Li Ding, Liyun Yuan
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Influence of Helicobacter pylori Infection and Eradication on Small Intestinal Bacterial Overgrowth and Abdominal Symptoms Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-15 Xiaolei Wang, Die Zhu, Siyu Li, Yun Dai, Guigen Teng, Weihong Wang
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Exosomes from Intrahepatic Cholestasis of Pregnancy Induce Cell Apoptosis Through the miRNA-6891-5p/YWHAE Pathway Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-15 Ningzhen Ye, Xinrui Shi, Jianyi Gao, Ruirui Dong, Gaoying Wang, Jing Wang, Liang Luo, Ting Zhang
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Effectiveness of Tofacitinib in Ulcerative Proctitis Compared to Left Sided Colitis and Pancolitis Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-15 Arshdeep Singh, Ramit Mahajan, Vandana Midha, Kirandeep Kaur, Dharmatma Singh, Ramandeep Kaur, Shreya Garg, Kirti Arora, Namita Bansal, Ajit Sood
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Bovine Colostrum Increases Intestinal Permeability in Healthy Athletes and Patients: A Meta-Analysis of Randomized Clinical Trials Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-15 Parisa Hajihashemi, Fahimeh Haghighatdoost, Nazila Kassaian, Laleh Hoveida, Babak Tamizifar, Hassan Nili, Marzieh Rahim Khorasani, Peyman Adibi
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Homeobox Protein BarH-like 1 Promotes Gastric Cancer Progression by Activating Coiled-Coil Domain-Containing Protein 178 Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-15 Yue Gu, Gang Chen, Xinwei Ning
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BEST-J Score: Validation of a Predicting Model for Delayed Bleeding After Gastric Endoscopic Submucosal Dissection on a European Sample Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-14
Abstract Background Delayed bleeding (DB) is a possible adverse event following gastric endoscopic submucosal dissection (ESD). The BEST-J score was created as a risk prediction model for DB following gastric ESD, but is yet to be validated in Western populations. Aims We aimed to validate the BEST-J score on a European sample and to perform a subgroup analysis according to histological classification
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Primary Sclerosing Cholangitis Limited to Intrahepatic Bile Ducts Has Distinctly Better Prognosis Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-12 Vijay S. Are, Mark A. Gromski, Fatih Akisik, Eduardo Vilar-Gomez, Craig Lammert, Marwan Ghabril, Raj Vuppalanchi, Naga Chalasani
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Predictors and Outcomes of Post-transjugular Intrahepatic Portosystemic Shunt Liver Failure in Patients with Cirrhosis Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-10 Amar Mukund, Ashish Aravind, Ankur Jindal, Harsh Vardhan Tevethia, Yashwant Patidar, Shiv K. Sarin
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Effectiveness and Safety of Tenofovir Alafenamide Fumarate in the Prevention of Perinatal Hepatitis B Transmission: A Meta-Analysis Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-10
Abstract Aim This study aimed to assess the effectiveness and safety of tenofovir alafenamide fumarate (TAF) in the prevention of mother-to-child transmission (MTCT) of hepatitis B virus (HBV). Methods We performed a meta-analysis of studies from the Cochrane Library, PubMed, ClinicalTrials.gov, Web of Science, EMBASE, China National Knowledge Infrastructure (CNKI), China Medical Information Network
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The Management of Direct Oral Anticoagulants for Colorectal Endoscopic Submucosal Dissection: A Multicenter Observational Study Digest. Dis. Sci. (IF 3.1) Pub Date : 2024-02-10 Jun Arimoto, Ken Ohata, Jun Tachikawa, Shungo Goto, Akimichi Hayashi, Yu Ebisawa, Mikio Kobayashi, Naoya Okada, Hiroki Kuwabara, Michiko Nakaoka, Eiji Sakai, Yuki Kano, Yohei Minato, Hitoshi Kuriyama, Hideyuki Chiba