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Lipid Metabolism-Related Gene Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Advanced Gastric Cancer Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2024-2-26 Lijian He, Qiange Ye, Yanmei Zhu, Wenqi Zhong, Guifang Xu, Lei Wang, Zhangding Wang, Xiaoping Zou
Objective. Abnormal lipid metabolism is known to influence the malignant behavior of gastric cancer. However, the underlying mechanism remains elusive. In this study, we comprehensively analyzed the biological significance of genes involved in lipid metabolism in advanced gastric cancer (AGC). Methods. We obtained gene expression profiles from The Cancer Genome Atlas (TCGA) database for early and advanced
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Efficacy of the Enteroadsorbent Silicol®gel in Adults with Irritable Bowel Syndrome Subtypes IBS-D or Mixed: Observational Open-Label Study Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-12-16 Gordon Crawford, Rory Taylor, David Young, Chris G. Hatton
Background. Irritable bowel syndrome (IBS) is a common chronic gut-brain interaction disorder with limited effective treatment options. Intestinal adsorbents have a high adsorption capacity for gut irritants and may provide nonpharmacological alternatives. Objectives. This post marketing study is aimed at providing up-to-date evidence to support the safety and efficacy in normal use of an established
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The Diagnostic Accuracy of a Fecal Immunochemical Test in Detecting Colorectal Cancer and Advanced Precancerous Colorectal Neoplasia in Patients with Iron Deficiency: A Protocol for Systematic Review and Meta-Analysis Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-12-8 Jennifer Pham, Geraldine Laven-Law, Jean M. Winter, Molla M. Wassie, Charles Cock, Erin L. Symonds
Background. Iron deficiency (ID) is a common micronutrient deficiency and the leading cause of anemia worldwide. ID can be caused by chronic occult blood loss from colorectal neoplasia including colorectal cancer (CRC) and advanced precancerous colorectal lesions. Current guidelines recommend colonoscopy in both men and postmenopausal women presenting with ID anemia (IDA). However, there is controversy
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Colonic Endoscopic Tubing Is Safe and Effective Approach for Washed Microbiota Transplantation in Autistic Children Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-11-22 Qing-Fen Yuan, Hui-Yi Wu, Xian-Yun Chen, Ya-Mei Zheng, Song-Lin Fu, Xing-He Wang, Jian-Wei Zhu, Jian-Dong Guo, Xing-Xiang He, Li-Hao Wu
Background. Washed microbiota transplantation (WMT) as the improved methods of fecal microbiota transplantation has been employed as a therapeutic approach for ameliorating symptoms associated with autism spectrum disorder (ASD). In this context, colonic transendoscopic enteral tubing (TET) has been utilized as a novel procedure for administering WMT. Methods. Data of children with ASD who received
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Benefits of Early Enteral Feeding with a Locally Prepared Protein-Energy Ration after Surgery for Acute Generalised Peritonitis: A Randomised Trial in Two Hospitals in Bukavu, Eastern Democratic Republic of Congo Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-11-17 Jean Paul Buhendwa Cikwanine, Jonathan Tunangoya Yoyu, Désiré Munyali Alumeti, Bernard Mugisho, John Mutendela Kivukuto, Rivain Fefe Iteke, Ona Longombe Ahuka, Willy Kalau Arung
Background. Acute generalised peritonitis (AGP) is a common and serious digestive surgery pathology. Undernutrition exacerbates patient condition and compromises their postoperative prognosis. Early enteral nutrition is recommended to reduce postoperative complications, but its availability and cost are problematic in low-income countries. The objective of this study was to evaluate the impact of providing
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Clinical Value of Detecting Fecal Calprotectin by Using Colloidal Gold Assay in Screening or Diagnosing Crohn’s Disease Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-11-9 Wangdong Zhang, Yanyun Fan, Meijun Chen
Background. Crohn’s disease (CD) is a chronic inflammatory disease, and its incidence is gradually increasing. Thus, the use of a simple and convenient examination method to detect CD in the natural population as early as possible is crucial. This study is aimed at using the colloidal gold semiquantitative assay to detect fecal calprotectin (FCP) and determine whether it is helpful in screening or
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Intestinal Ultrasound Combined with Blood Inflammatory Markers Is a More Efficient Tool in Evaluating Severity of Crohn’s Disease: A Pilot Study Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-11-8 Huaying Fang, Jie Liu, Kai Qian, Xuemei Xu, Zhaolong Li, Li Xie, Menghan Sun, Song Wang, Jiaqin Xu, Chaolan Lv, Bo Wang, Weiyong Liu, Gengqing Song, Yue Yu
Background and Aims. Intestinal ultrasound (IUS) is considered a nonirradiating, noninvasive, well-tolerated, and valuable tool for objectively assessing Crohn’s disease (CD) activity. However, there is no widely accepted intestinal ultrasound scoring system. This study is aimed at evaluating the efficacy of IUS key parameters, the International Bowel Ultrasound Activity Score (IBUS-SAS), and IBUS-SAS
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Risk Factors for Single and Multiple Recurrences for Endoscopic Retrograde Cholangiopancreatography and Open Choledochotomy in Treating Choledocholithiasis Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-10-31 Yao Wu, Ying Zhang, Xiao Meng Jiang, Chen Jing Xu, Yan Yan Wang, Jin Yuan Gu, Yi Li, Shun Fu Xu
Background. There are few studies comparing recurrences between endoscopic retrograde cholangiopancreatography (ERCP) and open choledochotomy (OCT). Aims. To compare the effect of different surgical methods on single and multiple recurrences of choledocholithiasis. Methods. A total of 1255 patients with choledocholithiasis who underwent ERCP or OCT were retrospectively studied. The recurrence of choledocholithiasis
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Correlation between Treatment Outcomes and Serum Vitamin D Levels As Well As Infliximab Trough Concentration among Chinese Patients with Crohn’s Disease Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-10-6 Xiaomei Song, Huihui Zhang, Hao Wang, Zhongyue Li, Xiaoqin Zhou, Hong Guo
Background. The relationship between vitamin D (vit-D) levels and the effectiveness of infliximab (IFX) in patients with Crohn’s disease (CD) remains controversial. Objective. To evaluate the interaction between vit-D levels and the response to IFX therapy in patients with CD. Methods. This was a retrospective cohort study. Serum vit-D and IFX trough concentrations (TC) were measured in 84 patients
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The Efficacy of 480 ml Oral Sodium Sulfate for Improving Insufficient Bowel Preparation of Colonoscopy with High-Concentrated Polyethylene Glycol Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-9-30 Naohisa Yoshida, Yoshikazu Inagaki, Daisuke Hasegawa, Reo Kobayashi, Yuri Tomita, Hikaru Hashimoto, Ryohei Hirose, Osamu Dohi, Ken Inoue, Yasutaka Morimoto, Yutaka Inada, Takaaki Murakami, Yoshito Itoh
Objectives. Oral sulfate solution (OSS) is used for bowel preparation (BP) during colonoscopy. The way of taking this agent can be used a same-day regimen (only on the day of colonoscopy) and split regimen (the day before and on the day of colonoscopy) for receiving it. In this study, we analyzed the efficacy of a same-day regimen of 480 ml OSS for insufficient bowel preparation (BP) with high-concentrated
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Main Diagnostic Criteria Usually Does Not Work for Autoimmune Pancreatitis Wrongly Presuming Malignancy Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-9-29 Lei Gong, Bin Shu, Fei Yu, Xinjing Zhang, Jianfei Chen, Jirun Peng
Background. Autoimmune pancreatitis (AIP) usually responds dramatically to steroid therapy. Occasionally, however, misdiagnosed patients have undergone pancreaticoduodenectomy. This study is aimed at providing useful information to improve the accuracy of diagnosis before surgery and thus avoid unnecessary resections in patients with AIP. Methods. From January 2015 to February 2020, a series of patients
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Gastrointestinal Infection in South African Children under the Age of 5 years: A Mini Review Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-8-23 Tshepo Mafokwane, Appolinaire Djikeng, Lucky T. Nesengani, John Dewar, Olivia Mapholi
Objective. To estimate gastroenteritis disease and its etiological agents in children under the age of 5 years living in South Africa. Methods. A mini literature review of pertinent articles published in ScienceDirect, PubMed, GoogleScholar, and Scopus was conducted using search terms: “Gastroenteritis in children,” “Gastroenteritis in the world,” Gastroenteritis in South Africa,” “Prevalence of gastroenteritis
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A Clinic-Radiomics Model for Predicting the Incidence of Persistent Organ Failure in Patients with Acute Necrotizing Pancreatitis Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-8-17 Nan Liu, Yidong Wan, Yifan Tong, Jie He, Shufeng Xu, Xi Hu, Chen Luo, Lei Xu, Feng Guo, Bo Shen, Hong Yu
Background. Persistent organ failure (POF) is the leading cause of death in patients with acute necrotizing pancreatitis (ANP). Although several risk factors have been identified, there remains a lack of efficient instruments to accurately predict the incidence of POF in ANP. Methods. Retrospectively, the clinical and imaging data of 178 patients with ANP were collected from our database, and the patients
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The Usefulness of the Alpha-Retroflex Position in Biliary Cannulation on Single-Balloon Enteroscopy-Assisted Endoscopic Retrograde Cholangiopancreatography in Patients with Roux-en-Y Gastrectomy: A Retrospective Study Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-8-4 Hiroo Imazu, Rota Osawa, Koji Yamada, Toshimi Takahashi, Muneo Kawamura, Shuzo Nomura, Suguru Hamana, Noriyuki Kuniyoshi, Mariko Fujisawa, Kei Saito, Hirofumi Kogure
Introduction. Balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography (BE-ERCP) is a useful therapeutic procedure that provides promising results in patients with surgically altered anatomy. However, biliary cannulation in BE-ERCP remains challenging. Therefore, in patients with Roux-en-Y gastrectomy, this study aimed to evaluate a BE-ERCP cannulation strategy that includes the
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Ultra-Proximal Jejunostomy Application after McKeown-Type Esophagectomy: A Retrospective Case-Series Study Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-8-2 Dongliang Lin, Zhendong Xu, Jinlong Huang, Wenshan Hong, Weiqing Zhang, Luoyu Lian
Background. Jejunostomy is the main form of enteral nutritional support after McKeown-type esophagectomy. However, this requires the jejunum to be secured to the abdominal wall, which can lead to catheter-related complications. Here, we present a new type of jejunostomy, ultra-proximal jejunostomy, which does not require fixation of the jejunum to the abdominal wall. Methods. Patients who underwent
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Correlation between Preoperative Platelet Count/(Lymphocyte Count × Prealbumin Count) Ratio and the Prognosis of Patients with Gastric Cancer Undergoing Radical Operation Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-7-28 Yi Liu, Yanguang Yang, Guomei Tai, Feng Ni, Cenming Yu, Wenjing Zhao, Ding Wang
Objective. To clarify the relationship between preoperative platelet count/(lymphocyte count × prealbumin count) ratio (PLPR) and the prognosis of patients with gastric cancer undergoing a radical operation, combined with Tumor Node Metastasis (TNM) staging, a scoring system was established to guide clinical application. Methods. The clinical data of 238 patients receiving radical operations for gastric
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Clinical Distribution Characteristics and Identification for Significant Liver Inflammation of Patients in Chronic Hepatitis B with Indeterminate Phase Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-7-11 Shanshan Chen, Xuan Dai, Yueyue Zhao, Jie Li, Xuehan Zou, Haijun Huang
Aim. In clinical practice, a considerable proportion of patients with chronic hepatitis B (CHB) who do not conform to any immune status are considered to be in the “indeterminate phase”. In this study, we aim to study the clinical distribution characteristics and identification of significant liver inflammation in patients in indeterminate phase. Methods. This study retrospectively analyze clinical
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Technical Review on Endoscopic Treatment Devices for Management of Upper Gastrointestinal Postsurgical Leaks Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-6-12 Renato Medas, Eduardo Rodrigues-Pinto
Upper gastrointestinal postsurgical leaks are challenging to manage and often require radiological, endoscopic, or surgical intervention. Nowadays, endoscopy is considered the first-line approach for their management, however, there is no definite consensus on the most appropriate therapeutic approach. There is a wide diversity of endoscopic options, from close-cover-divert approaches to active or
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Comparison of Gastric Cancer Risk Classifications Using Conventional and New Pepsinogen Criteria Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-5-30 Tae Sasakabe, Yuki Obata, Sayo Kawai, Yingsong Lin, Shogo Kikuchi
Background. New serum pepsinogen (PG) criteria have been shown to indicate more accurately infection with Helicobacter pylori (H. pylori). We sought to improve risk classification for gastric cancer by adopting the new PG criteria with the addition of an H. pylori antibody test. Methods. The study participants were 275 patients with gastric cancer and 275 apparently healthy controls from case–control
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Acupuncture Improved the Function of the Lower Esophageal Sphincter and Esophageal Motility in Chinese Patients with Refractory Gastroesophageal Reflux Disease Symptoms: A Randomized Trial Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-5-24 Tang Yuming, Zhao Yuping, Lin Yihan, Zhu Ying, Huang Jia, Shen Hanbing, Zou Duowu, Yao Weiyan
Objectives. Acupuncture is therapeutic for refractory gastroesophageal reflux disease by an unclear mechanism. This study was aimed at investigating the effect of acupuncture on esophageal motility in patients with symptoms of refractory gastroesophageal reflux disease. Methods. Sixty-eight patients with refractory gastroesophageal reflux disease symptoms were prospectively enrolled from August 2014
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Risk of Gastrointestinal Bleeding in Patients with End-Stage Renal Disease: The Link between Gut, Heart, and Kidneys Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-5-8 Avleen Kaur, Syed M. Baqir, Kundan Jana, Kalyana C. Janga
Patients with end-stage renal disease (ESRD) have a five times higher risk of gastrointestinal bleed (GIB) and mortality than the general population. Aortic stenosis (AS) has been associated with GIB from intestinal angiodysplasia. In this retrospective analysis, we obtained data from the 2012 and 2019 National Inpatient Sample. The primary outcome of interest was all-cause in-hospital mortality and
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Artificial Intelligence in Inflammatory Bowel Disease Endoscopy: Advanced Development and New Horizons Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-4-17 Yu Chang, Zhi Wang, Hai-Bo Sun, Yu-Qin Li, Tong-Yu Tang
Inflammatory bowel disease (IBD) is a complex chronic immune disease with two subtypes: Crohn’s disease and ulcerative colitis. Considering the differences in pathogenesis, etiology, clinical presentation, and response to therapy among patients, gastroenterologists mainly rely on endoscopy to diagnose and treat IBD during clinical practice. However, as exemplified by the increasingly comprehensive
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Endoscopic Screening for Missed Lesions of Synchronous Multiple Early Gastric Cancer during Endoscopic Submucosal Dissection Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-4-5 Jiangnan Wan, Yi Fang, Haizhong Jiang, Bujiang Wang, Lei Xu, Chunjiu Hu, Honghui Chen, Xiaoyun Ding
Aims. To evaluate the value of endoscopic screening during endoscopic submucosal dissection (ESD) in the detection of synchronous multiple early gastric cancer (SMEGC) and the risk factors for missed diagnosis of SMEGC. Methods. We conducted gastric endoscopic screening during ESD operation in 271 patients with early gastric cancer (EGC) referred for ESD, and endoscopic follow-up within 1 year after
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Astaxanthin Alleviates Inflammatory Response in Neonatal Necrotizing Enterocolitis Rats by Regulating NOD2/TLR4 Pathway Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-3-27 Xuandong Zhang, Yujia Luo, Rui Gu, Zhou Jiang
Background. Necrotizing enterocolitis (NEC) is often associated with exaggerated activation of inflammatory response. Astaxanthin has been shown in studies to have a positive and advantageous effect on anti-inflammatory response. Hence, it is of great significance to study the protective effect of astaxanthin in NEC disease and its molecular mechanism. Objective. The present study was to investigate
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EMP1 as a Potential Biomarker in Liver Fibrosis: A Bioinformatics Analysis Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-3-22 Xuchen Chen, Xinliang Lv, Manman Han, Yexiao Hu, Wanqiong Zheng, Haibo Xue, Zhuokai Li, Kui Li, Wei Tan
Liver fibrosis is a wound-healing response to chronic injury, which may result in cirrhosis and liver failure. Studies have been carried on the mechanisms and pathogenesis of liver fibrosis. However, the potential cell-specific expressed marker genes involved in fibrotic processes remain unknown. In this study, we combined a publicly accessible single-cell transcriptome of human liver with microarray
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Monitoring a Mandatory Nonmedical Switching Policy from Originator to Biosimilar Infliximab in Patients with Inflammatory Bowel Diseases: A Population-Based Cohort Study Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-3-1 Anat Fisher, Jason D. Kim, Colin R. Dormuth
Background. On September 5, 2019, British Columbia announced a new policy (the Biosimilars Initiative) to switch from originator to biosimilar infliximab for patients with inflammatory bowel diseases. Objective. To monitor the impacts of the policy on the use of medications and health services during the first year of the policy. Methods. In this population-based cohort study, we used administrative
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Comparison between Submucosal Tunneling Endoscopic Resection and Endoscopic Submucosal Dissection for Prepyloric Submucosal Tumors: A Case-Matched Controlled Study Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-3-1 Wengang Zhang, Jiafeng Wang, Ningli Chai, Enqiang Linghu
Objectives. Endoscopic submucosal dissection (ESD) has become a well-established treatment method for gastric submucosal tumors (SMTs). However, there existed some challenges to perform ESD for prepyloric SMTs on account of the special location. Recently, submucosal tunneling endoscopic resection (STER) provided a novel option for prepyloric SMTs. This study aimed to make a comprehensive comparison
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Economic Consequences of Surgery for Adhesive Small Bowel Obstruction: A Population-Based Study Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-2-25 Thorbjörn Sakari, Sophie Langenskiöld, Filip Sköldberg, Urban Karlbom
Background and Aims. Most patients develop adhesions after abdominal surgery, some will be hospitalized with small bowel obstruction (SBO), and some also require surgery. The operations and follow-up are expensive, but recent data of costs are scarce. The aim of this study was to describe the direct costs of SBO-surgery and follow-up, in a population-based setting. The association between cost of SBO
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The Efficacy of Surgical Resection versus Radiofrequency Ablation for the Treatment of Single Hepatocellular Carcinoma: A SEER-Based Study Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-2-21 Fang Wu, Chao Wei, Shicun Zhang, Shanshan Jia, Jidong Zhang
Background. There is controversy regarding whether patients with single hepatocellular carcinoma (HCC) should be offered radiofrequency ablation (RFA) as a first-line treatment option. Thus, this study compared overall survival after surgical resection (SR) and RFA for single HCC. Methods. The Surveillance, Epidemiology, and End Results (SEER) database was used for this retrospective study. The study
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Sedation Is Associated with Higher Polyp and Adenoma Detection Rates during Colonoscopy: A Retrospective Cohort Study Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-2-18 Chenghu Xu, Dehua Tang, Ying Xie, Muhan Ni, Min Chen, Yonghua Shen, Xiaotan Dou, Lin Zhou, Guifang Xu, Lei Wang, Ying Lv, Shu Zhang, Xiaoping Zou
Background and Aims. Currently sedation is a common practice in colonoscopy to reduce pain of patients and improve the operator satisfaction, whereas its impact on examination quality, especially adenoma detection rate (ADR) is still controversial. Thus, we aimed to investigate the association of sedation with ADR. Methods. Consecutive patients receiving colonoscopy between January 2017 and January
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Primary Esophageal Lymphoma: A Histopathological Experience from Two Tertiary Hospitals, Western Saudi Arabia Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-1-30 Jaudah Al-Maghrabi, Sahar Al-Maghrabi
Background. Primary esophageal lymphoma (PEL) is a rare disorder. The objective of this study was to document the clinicopathological features of PEL at two tertiary hospitals in the western region of the Kingdom of Saudi Arabia. Methods. All PELs diagnosed between May 2002 and June 2022 were retrieved. Histopathological and immunohistochemical slides were reviewed. Additional immunohistochemistry
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6-OHDA-Induced Changes in Colonic Segment Contractility in the Rat Model of Parkinson’s Disease Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-1-27 Maria Del Pilar Murillo, Ebba Johansson, Victoria Bryntesson, Patrik Aronsson, Gunnar Tobin, Michael Winder, Thomas Carlsson
Background. Gastrointestinal dysfunction is one of the most common non-motor symptoms in Parkinson’s disease (PD). The exact mechanisms behind these symptoms are not clearly understood. Studies in the well-established 6-hydroxydopamine (6-OHDA) lesioned rats of PD have shown altered contractility in isolated circular and longitudinal smooth muscle strips of distal colon. Contractile changes in proximal
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Downregulation of LncRNA SNHG7 Sensitizes Colorectal Cancer Cells to Resist Anlotinib by Regulating miR-181a-5p/GATA6 Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-1-14 Deng Pan, Kehe Chen, Ping Chen, Yu Liu, Yingying Wu, Jingning Huang
Long noncoding RNAs are a novel class of regulators in human cancers. It has been reported that small nucleolar RNA hostgene 7 (SNHG7) can sponge microRNAs to regulate colorectal cancer (CRC) progression. Given its important regulatory role in cancer biology, we wondered whether SNHG7 is involved in drug resistance to anlotinib (ATB) in CRC. To answer this, we quantified the expression of SNHG7 by
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Risk Factors Associated with Acute Pancreatitis after Percutaneous Biliary Intervention: We Do Not Know Nearly Enough Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2023-1-6 Jing Song, Jun Deng, Feng Wen
Percutaneous transhepatic cholangiodrainage (PTCD) and percutaneous transhepatic biliary stenting (PTBS) may be used as a palliative treatment for inoperable patients with malignant biliary obstruction (MBO) to improve the prognosis and their quality of life. However, acute pancreatitis is a common and severe complication that cannot be ignored after PTCD and PTBS in patients with MBO. A few cases
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Early Post-Operative Endoscopy Is Associated with Lower Surgical Recurrence of Crohn’s Disease: A Retrospective Study of Three Successive Cohorts Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-11-1 Caroline Amicone, Carla Coimbra Marques, Catherine Reenaers, Catherine Van Kemseke, Laurence Seidel, Edouard Louis
Background. The severity of endoscopic recurrence during the first year after intestinal resection for Crohn’s disease is predictive of clinical recurrence. The aim of our study was to assess the impact of the implementation of an ileocolonoscopy during the first year after surgery on surgical recurrence. Methods. All patients who underwent a first intestinal resection for Crohn’s disease between 1992
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Serum Lactate Dehydrogenase Is a Sensitive Predictor of Systemic Complications of Acute Pancreatitis Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-10-25 Dong-Ni Huang, Hao-Jie Zhong, Ying-Li Cai, Wen-Rui Xie, Xing-Xiang He
Background. Acute pancreatitis (AP) is a common and potentially life-threatening inflammatory disease that can cause various complications, including systemic inflammatory response syndrome (SIRS), pleural effusion, ascitic fluid, myocardial infarction, and acute kidney injury (AKI). However, there is still a lack of rapid and effective indicators to assess the disease. The aim of this study was to
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Detection and Treatment of Helicobacter pylori: Problems and Advances Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-10-22 Hang Yang, Liwen Guan, Bing Hu
Helicobacter pylori (H. pylori) infection is chronic and etiologically linked to gastric cancer (GC) derived from gastric epithelium. The potential mechanism is complex, covering chronic inflammation, epithelial senescence, NF-κB activation, the cytotoxin-associated gene A protein translocation, and related abnormal signaling pathways. In clinical practice, the test-and-treat strategy, endoscopy-based
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ZNF521 Is Correlated with Tumor Immune Cell Infiltration and Act as a Valuable Prognostic Biomarker in Gastric Cancer Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-10-19 Li Li, Zheng-Hui Liu, Hui-Ju Wang, Lei Wang, Guo-Qing Ru, Yuan-Yu Wang
Aim. To explore the correlations between the expression of zinc finger protein 521 (ZNF521) with immune invasion and prognosis of gastric cancer. Methods. Expression of ZNF521 was examined by immunohistochemistry in gastric cancer cases. Kaplan–Meier plotter was used to determine the relationships between ZNF521 and prognosis. TIMER and GEPIA were used to analyze the correlation between ZNF521 expression
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Jaundice on Presentation Is Associated with Higher In-Patient Mortality and Complications in Patients Admitted for Acute Pancreatitis: A Retrospective Study Based on National Inpatient Sample Database Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-10-18 Nishit Patel, Krishna Bodrya, Kirten Patel, Nishi Patel, Dhruvanshu Patel, Ronak Modi, Ayaz Matin
Pancreatitis usually presents with characteristic abdominal pain, radiological findings, and elevated lipase. The presence of jaundice may hint at a biliary etiology; however, it is not always present. We hypothesized that the presence of jaundice is associated with worse outcomes in patients admitted with pancreatitis. We conducted a retrospective analysis using the National Inpatient Sample, inquiring
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Feasibility of Novel Magnetically Controlled Cable Capsule Endoscopy System In Vitro Experiments for Gastric Examination Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-10-18 Yaoping Zhang, Lina Qu, Yani Gou, Jinyong Hao, Xiaojun Huang
Background. Magnetically controlled capsule endoscopy has been shown to be feasible for the examination of gastric diseases. However, there may be problems, such as low image quality, incomplete esophageal observation, and capsule retention. We developed a novel magnetically controlled cable capsule endoscopy (MCCCE) system and evaluated its feasibility through in vitro experiments. Methods. Three
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International Normalized Ratio-to-Albumin Ratio as a Novel Marker of Upper Gastrointestinal Bleeding Severity Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-10-13 Jeongwoo Choi, Je Seop Lee, Solmoon Lee, Yong Won Kim, Yoonsuk Lee, Tae Youn Kim
Introduction. Upper gastrointestinal bleeding (UGIB) is a potentially life-threatening gastrointestinal emergency, and effective management depends on early risk stratification. The Glasgow–Blatchford and Rockall scores are commonly used prognostic measures for UGIB, although these scoring systems are relatively difficult to apply in early emergency settings. AIMS65 with five items, albumin, international
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The Impact of ASCITIC Paracentesis on Symptomatic Outcomes in Palliative Patients: 3-Year Experience of a Melbourne Inpatient Palliative Care Unit Using Palliative Care Outcomes Collaboration Assessments Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-10-13 Kiran Iyer, Lucy Kernick
Background. Ascites formation is a common occurrence in patients receiving palliative care. This is associated with symptoms that may respond to drainage. Aim. To review and quantify ascites-related symptoms pre- and post-paracentesis to evaluate its benefit in an inpatient palliative care setting. Methods. A retrospective audit of patients admitted to an inpatient palliative care unit who underwent
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High Serum Squamous Cell Carcinoma Antigen Level Associated with Remission of Mild/Moderate Dysplasia of the Esophagus: A Nested Case–Control Study Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-10-13 Hui Su, Kuiliang Liu, Yanjie Zhao, Feng Shi, Yuchen Li, Jiangping Wu, Qingkun Song
Background. The esophageal epithelial dysplasia is the precancerous lesion. This study aimed to investigate the association between the serum squamous cell carcinoma antigen (SCCA) and the remission of esophageal squamous mild or moderate dysplasia. Methods. We performed a nested case–control study. Patients with mild/moderate dysplasia of the esophageal squamous epithelium were enrolled in this study
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Pre-Antibiotic Treatment Followed by Prolonged Repeated Faecal Microbiota Transplantation Improves Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome: An Observational Australian Clinical Experience Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-10-13 Harrison Hamblin, Anoja W. Gunaratne, Annabel Clancy, Denise Pilarinos, Antoinette LeBusque, Marie Vic M. Dawson, Thomas J. Borody
Background. The use of faecal microbiota transplantation (FMT) in irritable bowel syndrome (IBS) has frequently failed to induce long-term symptomatic improvement. The use of multiple FMT infusions is one proposed mechanism through which the efficacy of FMT can be amplified. Aims. To evaluate the safety and efficacy of a novel six-month FMT treatment protocol in IBS. Methods. Patients diagnosed with
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Alterations of Serum Bile Acid Profile in Patients with Crohn’s Disease Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-10-3 Rui Sun, Jingjing Jiang, Ling Yang, Lu Chen, Hong Chen
Background. Bile acid (BA) metabolism may be influenced by gut dysbiosis and alterations of intestinal epithelium in patients with Crohn’s disease (CD). Here, we aimed at investigating the alterations of serum BA profile in CD patients and analyzing the correlation between BAs and CD disease activity. Methods. A total of 62 CD patients (29 active and 33 remission) and 33 healthy volunteers (HVs) were
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Outcomes of Pediatric Patients with Crohn’s Disease Received Infliximab or Exclusive Enteral Nutrition during Induction Remission Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-09-02 Yao Lv, Yue Lou, Gan Yang, Youyou Luo, Jingan Lou, Qi Cheng, Jindan Yu, Youhong Fang, Hong Zhao, Kerong Peng, Jie Chen
Background. Both exclusive enteral nutrition (EEN) and infliximab (IFX) are recommended as induction therapy for pediatric Crohn’s disease (CD). Our aim was to compare long-term disease outcomes of patients initially received with either IFX or EEN. Methods. Medical records of newly diagnosed, therapy naïve pediatric patients with CD received with IFX or EEN as induction therapy were retrospectively
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Feasibility and Safety of ERCP in the Treatment of Biliary Strictures after Liver Transplantation: With a Report of 37 Cases Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-08-23 Fanfan Tang, Jingtao Song, Tanxing Cai, Zhao Lei, Feizhou Huang, Yina Hu, Gang Deng
Background. Liver transplantation (LT) is an effective treatment option for patients with end-stage liver disease; biliary complications are important cause of death in posttransplant patients. Endoscopic retrograde cholangiopancreatography (ERCP) has an irreplaceable role in the diagnosis and treatment of patients with biliary tract disease. Methods. The clinical data of patients with biliary strictures
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Predictors of Long-Time Survivors in Nonmetastatic Colorectal Signet Ring Cell Carcinoma: A Large Population-Based Study Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-08-17 Wuguang Zhang, Wenqian Gong, Changhai Wu, Mengting Li, Xiaolong Tu
Background. Colorectal signet ring cell carcinoma (SRCC) is a rare and distinct subtype of colorectal cancer (CRC), with extremely poor prognosis and aggressive tumor biological behavior. In this study, we aimed to analyze the clinicopathological characteristics and to identify the independent predictors of long-time survivors (LTSs) of nonmetastatic colorectal SRCC. Methods. Patients diagnosed with
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Performance of Deep Learning-Based Algorithm for Detection of Pediatric Intussusception on Abdominal Ultrasound Images Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-08-12 Zheming Li, Chunze Song, Jian Huang, Jing Li, Shoujiang Huang, Baoxin Qian, Xing Chen, Shasha Hu, Ting Shu, Gang Yu
Background and Aims. Diagnosing pediatric intussusception from ultrasound images can be a difficult task in many primary care hospitals that lack experienced radiologists. To address this challenge, this study developed an artificial intelligence- (AI-) based system for automatic detection of “concentric circles” signs on ultrasound images, thereby improving the efficiency and accuracy of pediatric
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Helicobacter pylori Thioredoxin1 May Play a Highly Pathogenic Role via the IL6/STAT3 Pathway Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-08-01 Yanlei Guo, Shigang Ding
Background. Recent studies have shown that CagA is considered highly pathogenic to helicobacter pylori (HP) in Western populations. However, in East Asia, CagA positive HP can be up to 90%, but not all patients will lead to gastric cancer. Our research group has found that HP thioredoxin1 (Trx1) may be a marker of high pathogenicity. Here, we investigate whether HP Trx1 exerts high pathogenicity and
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Exploring Different Effects of Exclusive Enteral Nutrition (EEN) and Corticosteroids on the Gut Microbiome in Crohn’s Disease Based on a Three-Stage Strategy Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-07-27 Dong Guo, Liang Fang, Ruiqing Liu, Yu Li, Liang Lv, Zhaojiao Niu, Dong Chen, Yanbing Zhou, Weiming Zhu
The objective of this study was to compare the efficacy of exclusive enteral nutrition (EEN) and corticosteroids on the gut microbiome in Crohn’s disease. Methods. Data were collected for 16 patients newly diagnosed with CD as the test group and 10 healthy volunteers as the control group. The 16 patients were randomly divided into the EEN group and the corticosteroids group. For subsequent analysis
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Efficacy and Safety of Exploring Deeper Sections of the Infrapapillary Area of the Duodenum by Using Sedative Esophagogastroduodenoscopy Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-07-27 Ming-Tse Hsu, Chi-Yi Chen, Kai-Sheng Liao, Wei-Sheng Chung
Background. Using conventional esophagogastroduodenoscopy (EGD) to evaluate the infrapapillary area is not feasible. The use of sedative EGD may enable endoscopists to investigate the infrapapillary condition of the duodenum. In this study, we aimed to evaluate lesions in the infrapapillary regions by using sedative EGD. Methods. In this retrospective observational study, we used the data of patients
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Acute Pancreatitis and Recurrent Acute Pancreatitis in Children: A 10-Year Retrospective Study Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-07-22 Chaohui Wang, Bao Fu, De Su, Ping Huang, Xiaoyun Fu
Aim. To compare the clinical characteristics of acute pancreatitis (AP) and recurrent acute pancreatitis (ARP) in children. Method. From January 2011 to January 2021, a total of 275 pediatric patients with AP admitted to a tertiary teaching hospital were enrolled. Results. The median age of 275 children was 12.0 years. Among them, 55 cases were ARP. The leading causes of pediatric pancreatitis were
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Preoperative Assessment of Patients Undergoing Bariatric Sleeve Gastrectomy: A Cross-Sectional Study Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-07-18 M. R. Tawfik, N. F. Aldawas, N. S. Almegbil, A. A. Bin Hamad, A. N. Alanazi, A. M. Alaidaroos, T. M. AlRawaf, A. A. Fayed
Introduction. Saudi Arabia (SA) is one of the top countries in the world when it comes to the number of bariatric procedures performed each year. There is still some debate on whether to do regular or selective upper endoscopy during the preoperative examination. The purpose of this study was to explore various endoscopic findings and Helicobacter pylori (HP) infection in symptomatic and asymptomatic
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Effects of Autologous Platelet-Rich Plasma on Healing of Peptic Ulcers: A Randomized Controlled Trial Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-07-15 Ting Xu, Yin Tian, Yi Wang, Zhongmei Yi, Chenchen Li, Shichun Wang, Yahan Fan, Chunyan Yao, Guiyong Peng, Hua Lu
Purpose. Peptic ulcer is a multifactorial and complex disease and affects a wide range of people worldwide. We provided a novel therapeutic approach for peptic ulcer and observed its effect. Methods. Peptic ulcer patients were enrolled from 2016 to 2017 in Chongqing and randomly assigned to two groups: a control group that used only rabeprazole and a platelet-rich plasma (PRP) group that received a
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Magnifying Chromoendoscopy with Flexible Spectral Imaging Color Enhancement, Indigo Carmine, and Crystal Violet in Predicting the Histopathology of Colorectal Polyps: Diagnostic Value in a Scare-Setting Resource Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-07-13 Nguyen Binh Pham, Khanh Truong Vu, Nam Hoai Nguyen, Ha Thi-Ngoc Doan, Thanh Trung Tran
Background and Aims. Virtual magnifying chromoendoscopy with flexible spectral imaging color enhancement (FICE), image-enhanced endoscopy techniques, and dye-staining magnifying chromoendoscopy (with Indigo carmine and Crystal violet) have contributed to better visualization of the pit pattern and vascular structure of colorectal polyp. Therefore, magnifying chromoendoscopy is capable of predicting
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Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-07-07 Mengjia Gao, Jingxin Xin, Xiaoling Li, Ling Gao, Shanshan Shao, Meng Zhao
Nonalcoholic steatohepatitis (NASH) is a liver disease caused by multiple factors, and there is no approved pharmacotherapy. The pathogenesis of NASH remains underexplored. In this study, differentially expressed circular RNAs (circRNAs) were obtained by analyzing NASH-related circRNA datasets, and then, corresponding target microRNAs (miRNAs) and messenger RNAs (mRNAs) were predicted to construct
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Prediction of Prognosis in Patients with Hepatocellular Carcinoma Based on Molecular Subtypes of Immune Genes Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-06-28 Suming Du, Jinhui Xu, Jiajia Shen, Xiaojin Zhang, Huanzhang Hu, Xinghua Huang
For those patients with hepatocellular carcinoma (HCC), it is really a heavy burden. Herein, the immune genes of HCC were analyzed in groups to determine prognostic biomarkers related to immune genes in HCC. The mRNA data, clinical data in TCGA-LIHC dataset, and immune gene in the ImmPort database were collected for the combining usage with -means concordance clustering to cluster HCC patients according
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Baseline Serum Estradiol Level Is Associated with Acute Kidney Injury in Patients with Moderately Severe and Severe Acute Pancreatitis Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-06-25 Jia-Jia Pan, Wei-Li Liu, Guo-Tao Lu, Xing-Jie Ma, Qing-Bin Zheng, Guang-Fa Wei, Ge-Yan Tian, Li-Jun Meng
Background. Sexual dimorphism with critical diseases has been documented. However, the role of serum sex hormones for the presence of acute kidney injury (AKI) in moderately or severe acute pancreatitis (MSAP and SAP) patients remains controversial. Here we set out to evaluate whether early (first 48 h) serum estradiol level is associated with AKI in patients with MSAP and SAP. Patients and Methods
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Research Progress on the Mechanism of Acupuncture Treatment for Nonalcoholic Fatty Liver Disease Gastroenterol. Res. Pract. (IF 2.0) Pub Date : 2022-06-22 Bai Li, Li Fang
Nonalcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease worldwide, ranging from simple steatosis and nonalcoholic steatohepatitis to fibrosis, cirrhosis, and hepatocellular carcinoma. Acupuncture is a long-established treatment in traditional Chinese medicine. In recent years, increasing evidence has pointed to the effectiveness of acupuncture in the treatment of NAFLD