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Association of lymphocyte subsets with the efficacy and prognosis of PD‑1 inhibitor therapy in advanced gastric cancer: results from a monocentric retrospective study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-15 Xinyan Wang, Xiaoling Liu, Huwei Dai, Junmei Jia
This retrospective study aimed to investigate the changes in peripheral blood lymphocyte subsets before and after immunotherapy in patients with advanced gastric cancer and their relationship n with the therapeutic efficacy and clinical prognosis. Peripheral blood lymphocyte subsets, including CD4 + T cells, CD8 + T cells, CD4+/CD8 + ratio, NK cells, Treg cells, and B cells, were collected from 195
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Poly-ϵ-caprolactone scaffold as staple-line reinforcement of rectal anastomosis: an experimental piglet study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-15 Laura Lovisa Køtlum Petersen, Martin Dennis Dursun, Gunvor Madsen, Dang Quang Svend Le, Sören Möller, Niels Qvist, Mark Bremholm Ellebæk
Rectal anastomoses have a persisting high incidence of anastomotic leakage. This study aimed to assess whether the use of a poly-ϵ-caprolactone (PCL) scaffold as reinforcement of a circular stapled rectal anastomosis could increase tensile strength and improve healing compared to a control in a piglet model. Twenty weaned female piglets received a stapled rectal anastomosis and were randomised to either
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The relationship between sarcopenia and metabolic dysfunction-associated fatty liver disease among the young and middle-aged populations BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-15 Ziyan Feng, Fanrong Zhao, Ziyao Wang, Xinyi Tang, Yan Xie, Li Qiu
Metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed as a new term for diagnosing fatty liver disease, which is considered to be a multi-systemic disease with multiple extrahepatic manifestations, including sarcopenia. The link between sarcopenia and MAFLD remains uncertain, especially among young and middle-aged adults. Thus, we examined the relationship between MAFLD and
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Comparison of vonoprazan and proton pump inhibitors for the treatment of gastric endoscopic submucosal dissection-induced ulcer: an updated systematic review and meta-analysis BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-15 Lizhen Chen, Dalei Jiang, Doudou Hu, Xianghua Cui
Both vonoprazan and proton pump inhibitors (PPIs) are currently used to treat artificial ulcers after gastric endoscopic submucosal dissection. However, evidence-based medicine proving the efficacy of vonoprazan is still lacking. Therefore, this meta-analysis aimed to compare the efficacy of vonoprazan and PPIs for the treatment of artificial ulcers after gastric endoscopic submucosal dissection. The
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Using new indices to predict metabolism dysfunction-associated fatty liver disease (MAFLD): analysis of the national health and nutrition examination survey database BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-15 Xu Ming Li, Song Lian Liu, Ya Jun He, Jian Chang Shu
Metabolism dysfunction-associated fatty liver disease (MAFLD), is the most common chronic liver disease. Few MAFLD predictions are simple and accurate. We examined the predictive performance of the albumin-to-glutamyl transpeptidase ratio (AGTR), plasma atherogenicity index (AIP), and serum uric acid to high-density lipoprotein cholesterol ratio (UHR) for MAFLD to design practical, inexpensive, and
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Prognostic factors of pancreatic tumors in children and adolescents: a population study based on the surveillance, epidemiology, and end results database BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-14 Xianzhong Qi, Bi Zhou, Fuhua Liang, Xinxin Wang
Pancreatic tumors in children are uncommon, and data is scarce. The purpose of this study is to examine the prognostic factors of pediatric pancreatic tumors in a population-based cohort. The Surveillance, Epidemiology, and End Results (SEER) database was used to identify all pediatric patients with pancreatic tumors diagnosed between 1975 and 2018. The overall survival (OS) rates were determined using
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Circulatory resistin levels in inflammatory bowel disease: a systematic review and meta-analysis BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-14 Amir Hossein Behnoush, Seyede Parmis Maroufi, Tara Reshadmanesh, Yasmin Mohtasham Kia, Mitra Norouzi, Seyedeh Mina Mohammadi, Aleksandra Klisic, Amirmohammad Khalaji
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic relapsing-remitting systemic disease of the gastrointestinal tract with rising incidence. Studies have shown that adipocytes play a crucial role in patients with IBD by actively participating in systemic immune responses. The present study was designed to investigate the correlation between the
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Effect and potential mechanism of oncometabolite succinate promotes distant metastasis of colorectal cancer by activating STAT3 BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-14 Jiangnan Yu, Hong Yang, Lin Zhang, Suye Ran, Qing Shi, Pailan Peng, Qi Liu, Lingyu Song
To investigate the effect of Oncometabolite succinate on colorectal cancer migration and invasion and to initially explore the underlying mechanism.Succinate acid detection kit detected the succinate content in tissues. The growth of colorectal cancer cells was measured by cck-8 assay, wound-healing migration assay and transwell migration and invasion assays, and then explored the level of epithelial-mesenchymal
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Symptoms, burden, and unmet needs of patients living with exocrine pancreatic insufficiency: a narrative review of the patient experience BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-14 Jodie A. Barkin, Trudi B. Delk, Valerie J. Powell
Exocrine pancreatic insufficiency (EPI) stems from a deficiency of functional pancreatic enzymes with consequent maldigestion and malnutrition. EPI shares clinical symptoms and manifestations with other disorders and is a considerable burden to individuals affected. In this narrative review, we analyzed the literature to identify relevant publications on living with EPI with the scope of individuating
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Clinical features of inflammatory bowel disease unclassified: a case-control study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-13 Yupei Shao, Yixiao Zhao, Hong Lv, Pengguang Yan, Hong Yang, Jingnan Li, Ji Li, Jiaming Qian
Approximately 10-15% of inflammatory bowel disease (IBD) patients with overlapping features of ulcerative colitis (UC) and Crohn’s disease (CD) are termed as inflammatory bowel disease unclassified (IBDU). This study aimed to describe the clinical features of IBDU and evaluate the potential associated factors of reclassification. The clinical data of 37 IBDU patients were retrospectively analyzed from
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Construction and validation of a nomogram for cancer specific survival of postoperative pancreatic cancer based on the SEER and China database BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-13 Wei Peng, Xiaopeng Yu, Renyi Yang, Sha Nie, Xiaolan Jian, Puhua Zeng
The recurrence rate and mortality rate among postoperative pancreatic cancer patients remain elevated. This study aims to develop and validate the cancer-specific survival period for individuals who have undergone pancreatic cancer surgery. We extracted eligible data from the Surveillance, Epidemiology, and End Results database and randomly divided all patients into a training cohort and an internal
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Hemorrhoidal disease among doctors from grade-A tertiary hospitals in big cities of China: results from web-based doctors as patients survey BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-13 Xiaoyuan Qiu, Yuxin Liu, Weikun Shi, Guole Lin, Mei Rong, Bingjie Wang
Doctors are at high risk of developing hemorrhoidal disease (HD), but it is unclear whether doctors are aware of this risk. The OASIS (dOctors AS patIentS) study was performed to examine the prevalence, awareness, diagnosis, and treatment of HD among doctors in big cities in China. An online survey consisting of a structured questionnaire was carried out among doctors in grade-A tertiary hospitals
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Gender differences in gastrointestinal, biopsychosocial and healthcare-seeking behaviors in Chinese patients with irritable bowel syndrome predominant with diarrhea BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-13 Wenjuan Fan, Yang Chen, Xiucai Fang, Liming Zhu, Guijun Fei, Jia Lu, Xiaoqing Li
Evidences of comparison of sex difference in Chinese irritable bowel syndrome (IBS) patients were few. We aim to compare gender difference in the biopsychosocial characteristics of Chinese patients of IBS predominant with diarrhea (IBS-D). IBS-D patients meeting Rome III criteria were enrolled. We administered IBS symptom questionnaires, evaluation of psychological status (HAMD and HAMA scales) and
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Investigating the mortality trend of gastrointestinal cancers in Babol, North Iran (2013–2021) BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-06 Pouyan Ebrahimi, Mohsen Karami, Sahar Delavari, Layla Shojaie, Seyed-Hossein Hosseini-Berneti, Fatemeh Bayani, Mehdi Moghaddasi, Ozra Babazade, Hossein-Ali Nikbakht
This study aims to examine the mortality rate and trend of gastrointestinal cancers, particularly gastric cancer, as the leading cause of death among cancers in northern Iran over a 9-year period. In light of the changing incidence and mortality rates of cancer in Iran and around the world, the importance of these diseases in people’s lives, and the necessity of updating and monitoring the trend of
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A colonial serrated polyp classification model using white-light ordinary endoscopy images with an artificial intelligence model and TensorFlow chart BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-05 Tsung-Hsing Chen, Yu-Tzu Wang, Chi-Huan Wu, Chang-Fu Kuo, Hao-Tsai Cheng, Shu-Wei Huang, Chieh Lee
In this study, we implemented a combination of data augmentation and artificial intelligence (AI) model—Convolutional Neural Network (CNN)—to help physicians classify colonic polyps into traditional adenoma (TA), sessile serrated adenoma (SSA), and hyperplastic polyp (HP). We collected ordinary endoscopy images under both white and NBI lights. Under white light, we collected 257 images of HP, 423 images
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Comparison of prognostic outcomes between endoscopic submucosal dissection and surgical treatment for early gastric cancer: a retrospective cohort study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-04 Yifan Zhang, Fangzhen Shi, Yuxiang Fan, Gang Liu, Chengkai Xia, Haodong Wang
The optimal management strategy for early gastric cancer (EGC) a topic of contention. This study aims to compare the prognostic outcomes of endoscopic submucosal dissection (ESD) and surgical treatment in patients diagnosed with EGC. In thisretrospective cohort study, we analyzed data from539 patients diagnosed with EGC between January 2012 and December 2020 from two centers. We compared Clinicopathological
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Nuclear respiratory factor 1 regulates super enhancer-controlled SPIDR to protect hepatocellular carcinoma cells from oxidative stress BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-04 Baowang Liu, Jian Dou, Jinglin Cao
Cellular response to oxidative stress plays significant roles in hepatocellular carcinoma (HCC) development, yet the exact mechanism by which HCC cells respond to oxidative stress remains poorly understood. This study aimed to investigate the role and mechanism of super enhancer (SE)-controlled genes in oxidative stress response of HCC cells. The GSE112221 dataset was used to identify SEs by HOMER
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Non-alcoholic fatty liver disease in Tanzania: prevalence, determinants, and diagnostic performance of triglycerides-glucose index and triglycerides-glucose index –body mass index compared to the hepatic ultrasound in overweight and obese individuals BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-04 Semvua B. Kilonzo, Eliud Kamala, Hyasinta Jaka, Patrick Ngoya
Non-alcoholic fatty liver disease (NAFLD), which is closely associated with metabolic syndrome (MetS), is rarely reported in Tanzania, where MetS is prevalent. The purpose of this study was to determine the prevalence and associated factors of this condition in overweight and obese individuals and to correlate standard ultrasound diagnosis with triglyceride-glucose index (TyG) and TyG-body mass index
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The association between hemoglobin level and sarcopenia in Chinese patients with Crohn’s disease BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-04 Nandong Hu, Jingjing Liu, Xifa Gao, Hongye Tang, Jiangchuan Wang, Zicheng Wei, Zhongqiu Wang, Xiaoli Yu, Xiao Chen
Sarcopenia and anemia are common complications in patients with Crohn’s Disease (CD). However, few studies have shown the association between sarcopenia and hemoglobin levels in CD patients. This retrospective study aimed to explore such association in Chinese patients with CD. Two hundred and twelve adult CD inpatients who underwent computed tomography (CT) or magnetic resonance imaging (MRI) examinations
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Preventive and therapeutic effects of rifaximin on hepatic encephalopathy with differential application dosages and strategies: a network meta-analysis BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-04 Guihua Fang, Shuna Liu, Bin Liu
Hepatic encephalopathy (HE) is a neuropsychiatric syndrome that affects the prognosis of patients with liver disease and is considered an independent risk factor for hospitalization and death. Rifaximin has been approved for HE treatment. This review will analyze the effect of rifaximin on different stages of HE with differential application dosages and strategies by traditional and network meta-analyses
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Prediction of survival and analysis of prognostic factors for patients with AFP negative hepatocellular carcinoma: a population-based study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-04 Chengyu Liu, Zikang Li, Zhilei Zhang, Jinlong Li, Congxi Xu, Yuming Jia, Chong Zhang, Wuhan Yang, Wenchuan Wang, Xiaojuan Wang, Kuopeng Liang, Li Peng, Jitao Wang
Hepatocellular carcinoma (HCC) has a poor prognosis, and alpha-fetoprotein (AFP) is widely used to evaluate HCC. However, the proportion of AFP-negative individuals cannot be disregarded. This study aimed to establish a nomogram of risk factors affecting the prognosis of patients with AFP-negative HCC and to evaluate its diagnostic efficiency. Data from patients with AFP-negative initial diagnosis
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Efficacy of transcatheter arterial embolization in treating nonvariceal gastric remnant bleeding: a retrospective 5-year study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-04 Weida Wu, Jianyang Peng, Guohui Zhou, Chunsheng Zhang, Yuanzhen Lin, Zhicheng Weng
Gastric remnant bleeding is a special case of upper gastrointestinal bleeding with certain specific disease characteristics, and some matters of transcatheter arterial embolization (TAE) for hemostasis need attention. In this study, we aimed to explore the clinical use of TAE in patients with nonvariceal gastric remnant bleeding and identify the factors influencing the clinical efficacy of these interventions
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Downregulation of SMOC1 is associated with progression of colorectal traditional serrated adenomas BMC Gastroenterol. (IF 2.4) Pub Date : 2024-03-01 Hironori Aoki, Akira Takasawa, Eiichiro Yamamoto, Takeshi Niinuma, Hiro-o Yamano, Taku Harada, Toshiyuki Kubo, Akira Yorozu, Hiroshi Kitajima, Kazuya Ishiguro, Masahiro Kai, Akio Katanuma, Toshiya Shinohara, Hiroshi Nakase, Tamotsu Sugai, Makoto Osanai, Hiromu Suzuki
Aberrant DNA methylation is prevalent in colorectal serrated lesions. We previously reported that the CpG island of SMOC1 is frequently methylated in traditional serrated adenomas (TSAs) and colorectal cancers (CRCs) but is rarely methylated in sessile serrated lesions (SSLs). In the present study, we aimed to further characterize the expression of SMOC1 in early colorectal lesions. SMOC1 expression
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Scoping review of values elicitation tools for treatment decisions in hepatocellular carcinoma BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-28 Gabrielle Ritaccio, A. Sidney Barritt IV, Jamie L. Conklin, Daniel R. Richardson, Donna M. Evon, Hanna K. Sanoff, Ethan Basch, Stephanie B. Wheeler, Andrew M. Moon
Treatment choices in hepatocellular carcinoma (HCC) involve consideration of tradeoffs between the benefits, toxicities, inconvenience, and costs. Stated preference elicitation methods have been used in the medical field to help evaluate complex treatment decision-making. The aim of this study was to conduct a scoping review to assess the evidence base for the use of preference elicitation tools or
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Development and validation of comprehensive nomograms from the SEER database for predicting early mortality in metastatic rectal cancer patients BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-26 Yanli Li, Ting Tao, Yun Liu
Metastatic rectal cancer is an incurable malignancy, which is prone to early mortality. We aimed to establish nomograms for predicting the risk of early mortality in patients with metastatic rectal cancer. In this study, clinical data were obtained from the Surveillance, Epidemiology, and End Results (SEER) database.We utilized X-tile software to determine the optimal cut-off points of age and tumor
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The frequency of colorectal lesions in the first-degree relatives of patients with colorectal lesions among PERSIAN Guilan Cohort Study population (PGCS) BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-26 Somaieh Matin, Farahnaz Joukar, Saman Maroufizadeh, Mehrnaz Asgharnezhad, Paridokht Karimian, Fariborz Mansour-Ghanaei
This study aimed to investigate the frequency of colorectal lesions in the first-degree relatives of patients with colorectal lesions among the Prospective Epidemiological Research Studies in Iran (PERSIAN )Guilan Cohort Study (PGCS) population. In this cross-sectional study, 162 first-degree relatives with a history of colorectal lesions were randomly selected from 52 participants in PGCS. All subjects
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The effects of low-dose IL-2 on Th17/Treg cell imbalance in primary biliary cholangitis mouse models BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-26 Zilong Wang, Zhicheng Liu, Jiarui Zheng, Linxiang Huang, Rui Jin, Xiaoxiao Wang, Dongbo Chen, Yandi Xie, Bo Feng
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease. The imbalance of Th17/Treg cells has been reported in PBC patients. Low-dose IL-2 can alleviate disease severity through modulating CD4 + T cell subsets in patients with autoimmune diseases. Hence, the present study aimed to examine the effects and mechanism of low-dose IL-2 in PBC mouse models. PBC models were induced in female
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Correction: The important role of whole-process computed tomography guidance for percutaneous gastrostomy in esophageal cancer patients who are unsuitable for or have had unsuccessful attempts with endoscopic and fuoroscopic gastrostomy BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-26 Xiang Geng, Qing Zhao, Hang Yuan, Hai-Liang Li, Chen-Yang Guo, Ting Yang, Wei-Jun Fan, Jung-Hoon Park, Xiao-Hui Zhao, Wen-Bo Zhu, Hong-Tao Hu
Correction: BMC Gastroenterol (2024) 24:14 https://doi.org/10.1186/s12876-023-03040-7 Following publication of the original article it was reported that there was an error in affiliation 1, namely that ‘Henan Cancer Hospital’ preceded ‘The Affiliated Cancer Hospital of Zhenzhou Univeristy’. The original article has been updated.Author notes Xiang Geng and Qing Zhao contributed equally to this work
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The impact of Karnofsky performance status on prognosis of patients with hepatocellular carcinoma in liver transplantation BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-26 Jie Zhou, Danni Ye, Siyao Zhang, Jiawei Ding, Tao Zhang, Zheng Chen, Fangshen Xu, Shenli Ren, Zhenhua Hu
Functional performance as measured by the Karnofsky Performance Status (KPS) scale has been linked to the outcomes of liver transplant patients; however, the effect of KPS on the outcomes of the hepatocellular carcinoma (HCC) liver transplant population has not been fully elucidated. We aimed to investigate the association between pre-transplant KPS score and long-term outcomes in HCC patients listed
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miR-541 is associated with the prognosis of liver cirrhosis and directly targets JAG2 to inhibit the activation of hepatic stellate cells BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-23 Jin-Pei Liu, Shao-Hua Song, Pei-Mei Shi, Xiao-Yu Qin, Bai-Nan Zheng, Shu-Qing Liu, Chen-Hong Ding, Xin Zhang, Wei-Fen Xie, Yi-Hai Shi, Wen-Ping Xu
The activation of hepatic stellate cells (HSCs) has been emphasized as a leading event of the pathogenesis of liver cirrhosis, while the exact mechanism of its activation is largely unknown. Furthermore, the novel non-invasive predictors of prognosis in cirrhotic patients warrant more exploration. miR-541 has been identified as a tumor suppressor in hepatocellular carcinoma and a regulator of fibrotic
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Correlation between white blood cell count and intestinal resection in patients with acute mesenteric vein thrombosis BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-23 Yu Xu, Shang-Tai Dai, Hong-Qiao Lu, Wei Chen, Zhi-Wei Xiong, Jiang Liu, Yong-Jiang Tang, Shi-Kui Guo, Kun-Mei Gong
Acute mesenteric vein thrombosis (AMVT) is an acute abdominal disease with onset, rapid progression, and extensive intestinal necrosis that requires immediate surgical resection. The purpose of this study was to determine the risk factors for nosocomial intestinal resection in patients with AMVT. We retrospectively analysed 64 patients with AMVT diagnosed by CTA at the Affiliated Hospital of Kunming
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Association between colorectal cancer, the frequency of Bacteroides fragilis, and the level of mismatch repair genes expression in the biopsy samples of Iranian patients BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-23 Nooshin Nazarinejad, Bahareh Hajikhani, Amir Abbas Vaezi, Farzaneh Firoozeh, Fatemeh Sameni, Somayeh Yaslianifard, Mehdi Goudarzi, Masoud Dadashi
Deficient DNA mismatch repair (MMR) can cause microsatellite instability (MSI) and is more common in colorectal cancer (CRC) patients. Understanding the carcinogenic mechanism of bacteria and their impact on cancer cells is crucial. Bacteroides fragilis (B. fragilis) has been identified as a potential promoter of tumorigenesis through the alteration of signaling pathways. This study aims to assess
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Comparative study of ultrasound attenuation analysis and controlled attenuation parameter in the diagnosis and grading of liver steatosis in non-alcoholic fatty liver disease patients BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-23 Mengyun Wang, Shuzhen Tang, Guoqiu Li, Zhibin Huang, Sijie Mo, Keen Yang, Jing Chen, Baishan Du, Jinfeng Xu, Zhimin Ding, Fajin Dong
To assess the diagnostic performance of Ultrasound Attenuation Analysis (USAT) in the diagnosis and grading of hepatic steatosis in patients with non-alcoholic fatty liver disease (NAFLD) using Controlled Attenuation Parameters (CAP) as a reference. From February 13, 2023, to September 26, 2023, participants underwent CAP and USAT examinations on the same day. We used manufacturer-recommended CAP thresholds
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Reading of small bowel capsule endoscopy after frame reduction using an artificial intelligence algorithm BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-22 Dong Jun Oh, Youngbae Hwang, Sang Hoon Kim, Ji Hyung Nam, Min Kyu Jung, Yun Jeong Lim
Poorly visualized images that appear during small bowel capsule endoscopy (SBCE) can confuse the interpretation of small bowel lesions and increase the physician’s workload. Using a validated artificial intelligence (AI) algorithm that can evaluate the mucosal visualization, we aimed to assess whether SBCE reading after the removal of poorly visualized images could affect the diagnosis of SBCE. A study
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Impact of insomnia upon inflammatory digestive diseases and biomarkers: a two-sample mendelian randomization research on Europeans BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-21 Lei Dai, Yunyan Ye, Joseph Mugaanyi, Caide Lu, Changjiang Lu
A number of observational studies indicate that insomnia is linked to inflammatory digestive diseases (IDDs). However, the definite relationship between insomnia and IDDs remains unclear. We obtained the publicly available data from genome-wide association studies (GWAS) to conduct two-sample Mendelian randomization (MR) for association assessment. Five MR analysis methods were used to calculate the
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A comprehensive study on non-cancer-related mortality risk factors in elderly gastric cancer patients post-curative surgery BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-19 Yuki Ushimaru, Shinnosuke Nagano, Kazuhiro Nishikawa, Ryohei Kawabata, Tomohira Takeoka, Akihiro Kitagawa, Nobuyoshi Ohara, Hideo Tomihara, Sakae Maeda, Mitsunobu Imazato, Shingo Noura, Atsushi Miyamoto
The increasing incidence of gastric cancer in the elderly underscores the need for an in-depth understanding of the challenges and risks associated with surgical interventions in this demographic. This study aims to investigate the risk factors and prognostic indicators for non-cancer-related mortality following curative surgery in elderly gastric cancer patients. This retrospective analysis examined
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Investigating the shared genetic architecture between primary sclerosing cholangitis and inflammatory bowel diseases: a Mendelian randomization study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-19 Xuan Dong, Li-Li Gong, Mei-Zhu Hong, Jin-Shui Pan
Several studies have found that primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) are closely associated. However, the direction and causality of their interactions remain unclear. Thus, this study employs Mendelian Randomization to explore whether there are causal associations of genetically predicted PSC with IBD. Genetic variants associated with the genome-wide association
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The pertinence of gastric cancer and interleukin 10–819 single nucleotide polymorphisms: a meta-analysis and systematic review BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-16 Qianqian Mao, Yanwen Liu, Xi Chen, Cheng Jiang Liu
Cytokines regulate the interaction between the immune system and malignant tumors. Among them, interleukin-10 (IL-10) is a multifunctional anti-inflammatory cytokine mainly produced by immune cells. The correlation between gastric cancer and T/C single nucleotide polymorphism (SNP) of interleukin-10 (IL-10) promoter−819(rs1800871)was opaque and remained to be determined. We aim to explore the pertinence
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Relationship between observation time and detection rate of focal lesions in Esophagogastroduodenoscopy: a single-center, retrospective study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-15 Li Dong, Xiaodan Zhang, Yuting Xuan, Peiling Xiong, Yumei Ning, Bing Zhang, Fan Wang, Qiu Zhao, Jun Fang
Current studies have shown that longer observation time can improve neoplastic detection rate. This study aimed to clarify whether endoscopists with longer observation times can detect more focal lesions. Based on the mean examination time for Esophagogastroduodenoscopy (EGD) without biopsy, endoscopists were divided into fast and slow groups, and the detection rate of focal lesions was compared between
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Safety and feasibility of minimally invasive gastrectomy following preoperative chemotherapy for highly advanced gastric cancer BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-15 Tsuyoshi Tanaka, Koichi Suda, Susumu Shibasaki, Akiko Serizawa, Shingo Akimoto, Masaya Nakauchi, Hiroshi Matsuoka, Kazuki Inaba, Ichiro Uyama
This study aimed to determine the safety and feasibility of minimally invasive gastrectomy in patients who underwent preoperative chemotherapy for highly advanced gastric cancer. Preoperative chemotherapy was indicated for patients with advanced large tumors (≥ cT3 and ≥ 5 cm) and/or bulky node metastasis (≥ 3 cm × 1 or ≥ 1.5 cm × 2). Between January 2009 and March 2022, 150 patients underwent preoperative
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Comparative efficacy and safety of Sofosbuvir/Velpatasvir and Danoprevir for the treatment of chronic hepatitis C: the real-world data in China BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-14 Yunjing Zhou, Minfeng Liang, Yiting Li, Xing Chen, Jie Yang, Honglian Bai, Yingzi Long, Xiaohong Zhang, Chaoshuang Lin
Sofosbuvir/Velpatasvir (Epclusa, ECS) is the first pan-genotype direct-acting antiviral agent (DAA) for hepatitis C virus (HCV) infection, and Danoprevir (DNV) is the first DAA developed by a Chinese local enterprise, which is suitable for combined use with other drugs to treat genotype 1b chronic hepatitis C. However, previous reports have never compared the real-world data of ECS and DNV. 178 chronic
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Development of a prediction model for predicting the prevalence of nonalcoholic fatty liver disease in Chinese nurses: the first-year follow data of a web-based ambispective cohort study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-14 Ying Che, Rongsong Tang, Heli Zhang, Min Yang, Rongmei Geng, Lin Zhuo, Peng Wang, Xianjing Hu, Yujie Zhou, Panfeng Wang, Siyan Zhan, Baohua Li
Nonalcoholic fatty liver disease (NAFLD) is gradually becoming a huge threat to public health. With complex working characteristics, female nurses had been found with high risk of NAFLD. To develop and validate a prediction model to predict the prevalence of NAFLD based on demographic characteristics, work situation, daily lifestyle and laboratory tests in female nurses. This study was a part of the
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Effectiveness of a thrombin-gelatin flowable for treating severe liver bleeding: an experimental study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-14 Francisco J Sánchez-del-Valle, María-Isabel Sánchez-Seco, Adrián González Jiménez, Florentina Acosta, Pedro Fernández-Domínguez, Juan-José Pérez-Alegre
Current scientific evidence has pointed out the relevance of hemostatic products for improving clinical outcomes in liver trauma, including increased survival rates and reductions in bleeding-related complications. The purpose of this study was to compare the use of the gelatin-thrombin flowable (Flowable) versus the standard technique of Packing in a new experimental liver injury model. Twenty-four
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Microscopic colitis found together with celiac disease in a female population is associated with one episode of lymphocytic colitis BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-12 Bodil Roth, Bodil Ohlsson
Microscopic colitis (MC) is considered a chronic disease associated with autoimmune disease, smoking, and drugs. The aim was to examine the association between MC and celiac disease, adjusted for smoking, considering subtypes and clinical course of the disease in a retrospectively collected female cohort. Women (n = 240), ≤ 73 years, diagnosed as MC in medical records or pathological registers were
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Efficacy of endoscopic submucosal resection with a ligation device for small rectal neuroendocrine tumor: study protocol of a multicenter open-label randomized control trial (BANDIT trial) BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-08 Kazunori Takada, Kenichiro Imai, Takanori Yamada, Ken Ohata, Takashi Kanesaka, Yasuaki Nagami, Yasushi Yamasaki, Hideki Kobara, Yasuhiro Inokuchi, Akiko Chino, Shinjiro Yamaguchi, Hisatomo Ikehara, Takuji Kawamura, Yohei Yabuuchi, Yasuhiko Mizuguchi, Hiroaki Ikematsu, Chizu Yokoi, Santa Hattori, Kazuya Ohno, Yashiro Yoshizawa, Masakatsu Fukuzawa, Yosuke Tsuji, Jun Konishi, Takeshi Yamamura, Satoshi
Endoscopic resection is widely accepted as a local treatment for rectal neuroendocrine tumors sized ≤ 10 mm. However, there is no consensus on the best method for the endoscopic resection of rectal neuroendocrine tumors. As a simplified endoscopic procedure, endoscopic submucosal resection with a ligation device (ESMR-L) indicates a histologically complete resection rate comparable to that of endoscopic
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Possible use of 2D shear wave liver elastography in new-onset ascites evaluation BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-08 Andrej Hari, Borut Štabuc
No data on the use of 2D shear wave elastography exists regarding the evaluation of the new-onset ascites causality. To determine whether 2D shear wave elastography can help in the non-invasive assessment of the new-onset ascites cause. To assess the applicability of liver stiffness measured by 2D shear wave elastography using Esaote MyLab Nine apparatus in patients with ascites. In 52 consecutive
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Correction: PTEN-induced kinase 1 gene single-nucleotide variants as biomarkers in adjuvant chemotherapy for colorectal cancer: a retrospective study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-06 Yoshiaki Mihara, Masataka Hirasaki, Yosuke Horita, Takashi Fujino, Hisayo Fukushima, Yasuo Kamakura, Kousuke Uranishi, Yasumitsu Hirano, Shomei Ryozawa, Masanori Yasuda, Yoshinori Makino, Satomi Shibazaki, Tetsuya Hamaguchi
Correction: BMC Gastroenterol 23, 339 (2023) https://doi.org/10.1186/s12876-023-02975-1 Following publication of the original article [1] the authors reported an error in Fig. 2. A technical error (reversing the definition of "1" and "0" for censored cases and deaths) when creating the Kaplan–Meier survival curve resulted in an incorrect curve. Furthermore, the original Fig. 2 was missing a numerical
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Comparing the effectiveness of transdiagnostic treatment with acceptance and commitment therapy on emotional disorders, rumination, and life satisfaction in patients with irritable bowel syndrome: a randomized clinical trial BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-06 Homa Shahkaram, Jafar Sarani Yaztappeh, Amir Sadeghi, Amir Sam Kianimoghadam, Samaneh Soltanabadi, Maryam Bakhtiari, Abbas Masjedi Arani
The present study was conducted to compare the effectiveness of transdiagnostic treatment (UP) with the acceptance and commitment therapy (ACT) on the emotional disorders, rumination, and life satisfaction in the patients with irritable bowel syndrome (IBS). The present study was a randomized clinical trial with a pre-test and post-test design. Between the winter of 2021 and the end of spring 2022
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Colorectal cancer pre-diagnostic symptoms are associated with anatomic cancer site BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-06 Nicole L. Briggs, Mimi Ton, Rachel C. Malen, Adriana M. Reedy, Stacey A. Cohen, Amanda I. Phipps, Andrea N. Burnett-Hartman, Polly A. Newcomb
Signs and red flag symptoms in colorectal cancer (CRC) patients who are below the recommended screening age are often overlooked, leading to delayed diagnosis and worse prognosis. This study investigates how patient pre-diagnostic symptoms are associated with anatomic site of their cancer and whether the association varies by age at CRC diagnosis. We ascertained CRC patients’ experienced symptoms and
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Risk factors for gastroesophageal reflux disease: a population-based study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-05 Sepehr Sadafi, Ali Azizi, Yahya Pasdar, Ebrahim Shakiba, Mitra Darbandi
Gastroesophageal reflux disease (GERD) in the long term reduces the quality of life, leading to digestive diseases. The present study aims to determine the risk factors for GERD. This study was conducted on 9,631 adults aged 35–65 years. The demographic characteristics, behavioral habits, nutritional intake, physical activity, anthropometric indices, and GERD data were extracted from the databank related
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An inflammation-based model for identifying severe acute pancreatitis: a single-center retrospective study BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-05 Xiaotong Li, Yiyan Zhang, Weiwei Wang, Yao Meng, Huimin Chen, Guiyang Chu, Hongyu Li, Xingshun Qi
Severe acute pancreatitis (SAP) is potentially lethal. Considering the role of inflammation in the progression of acute pancreatitis (AP), this study aims to develop a model based on inflammatory indexes for identifying the presence of SAP. Overall, 253 patients with AP who were consecutively admitted between July 2018 and November 2020 were screened, of whom 60 had SAP. Systemic immune-inflammation
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Effect of cognitive-behavior therapy for children with functional abdominal pain: a meta-analysis BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-03 Xiaolan Huang, Nan Jia, Yan Zhang, Yanyan Hao, Fei Xiao, Chunrong Sun, Xiaodai Cui, Fei Wang
Cognitive-Behavior Therapy (CBT) is the validated non-pharmacological treatment for chronic pain in pediatric patients. While some suggested CBT were comparable to the usual care in reducing children’s functional abdominal pain. This meta-analysis was designed to systematically review the literature for RCTs that investigated the efficacy of CBT in children with functional abdominal pain (FAP). PubMed
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Comparison of the efficacy and tolerability of elobixibat plus sodium picosulfate with magnesium citrate and split-dose 2-L polyethylene glycol with ascorbic acid for bowel preparation before outpatient colonoscopy: a study protocol for the multicentre, randomised, controlled E-PLUS trial BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-03 Kinichi Hotta, Yosuke Otake, Daisuke Yamaguchi, Yuichi Shimodate, Norihiro Hanabata, Hiroaki Ikematsu, Yohei Yabuuchi, Yasushi Sano, Ryo Shimoda, Shinya Sugimoto, Mari Oba, Hiroyuki Takamaru, Kouichiro Kimura, Yoshihiro Kishida, Kazunori Takada, Sayo Ito, Kenichiro Imai, Kazuya Hosotani, Tatsuro Murano, Masayoshi Yamada, Kensuke Shinmura, Rio Takezawa, Michito Tomonaga, Yutaka Saito
Sodium picosulfate (SP)/magnesium citrate (MC) and polyethylene glycol (PEG) plus ascorbic acid are recommended by Western guidelines as laxative solutions for bowel preparation. Clinically, SP/MC has a slower post-dose defaecation response than PEG and is perceived as less cleansing; therefore, it is not currently used for major bowel cancer screening preparation. The standard formulation for bowel
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Transcriptional landscape of intestinal environment in DSS-induced ulcerative colitis mouse model BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-02 Yuefei Wen, Chenyang Li, Peng Huang, Zhigang Liu, Yanjun He, Bin Liu
Ulcerative colitis (UC) is a chronic inflammatory disease that targets the colon and has seen an increasing prevalence worldwide. In our pursuit of new diagnostic and therapeutic approaches for UC, we undertook a sequencing of colons from UC mouse models. We focused on analyzing their differentially expressed genes (DEGs), enriching pathways, and constructing protein-protein interaction (PPI) and Competing
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Dietary intervention reverses molecular markers of hepatocellular senescence in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-02 Mathias Flensted-Jensen, Denise Oró, Emma A. Rørbeck, Chen Zhang, Martin Rønn Madsen, Andreas Nygaard Madsen, Jenny Norlin, Michael Feigh, Steen Larsen, Henrik H. Hansen
Hepatocellular senescence may be a causal factor in the development and progression of non-alcoholic steatohepatitis (NASH). The most effective currently available treatment for NASH is lifestyle intervention, including dietary modification. This study aimed to evaluate the effects of dietary intervention on hallmarks of NASH and molecular signatures of hepatocellular senescence in the Gubra-Amylin
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Effectiveness of bevacizumab in the treatment of metastatic colorectal cancer: a systematic review and meta-analysis BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-01 Yu Song, Qianqian Mao, Manling Zhou, Cheng-Jiang Liu, Li Kong, Ting Hu
To evaluate the benefit of bevacizumab under the comprehensive treatment strategy and its advantages over other drugs, so as to provide reference for the formulation of clinical plans. As of October 1, 2022, the randomized controlled clinical trials of bevacizumab in combination with metastatic colorectal cancer published in PubMed, Cochrane Library and Medline databases were searched. The odds ratio
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Identification of differentially methylated regions associated with both liver fibrosis and hepatocellular carcinoma BMC Gastroenterol. (IF 2.4) Pub Date : 2024-02-01 Suguru Kurokawa, Takuro Kobori, Masato Yoneda, Yuji Ogawa, Yasushi Honda, Takaomi Kessoku, Kento Imajo, Satoru Saito, Atsushi Nakajima, Kikuko Hotta
Liver fibrosis is a major risk factor for hepatocellular carcinoma (HCC). We have previously reported that differentially methylated regions (DMRs) are correlated with the fibrosis stages of metabolic dysfunction-associated steatotic liver disease (MASLD). In this study, the methylation levels of those DMRs in liver fibrosis and subsequent HCC were examined. The methylation levels of DMRs were investigated
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Clinical features and fecal microbiota characteristics of patients with both ulcerative colitis and axial spondyloarthritis BMC Gastroenterol. (IF 2.4) Pub Date : 2024-01-31 Lei Zhangni, Xiao Mofan, Chen Yuling, Li Yingchao
The role of the intestinal microbiota in the pathogenesis of inflammatory bowel disease combined with axial spondyloarthritis (axSpA) is gaining widespread interest. This study was conducted to investigate the clinical and fecal microbiota characteristics of patients with both ulcerative colitis (UC) and axSpA. Clinical data were collected from patients with UC. Patients were divided into the axSpA
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Efficacy and safety of the combination of camrelizumab and apatinib in the treatment of liver cancer: a systematic review and single-arm meta-analysis BMC Gastroenterol. (IF 2.4) Pub Date : 2024-01-31 Min Chen, Yanglei Li, Minyu Cheng
To evaluate the efficacy and safety of the combination of camrelizumab and apatinib in the treatment of liver cancer and to furnish clinical recommendations for pharmacological interventions. PubMed, Embase, Web of Science and the Cochrane Library were scrutinized for research publications from their inception to 22 December 2023. Bibliographic perusal and data procurement were executed. The quality
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Evaluation of soluble suppression of tumorigenicity 2 (sST2) as serum marker for liver fibrosis BMC Gastroenterol. (IF 2.4) Pub Date : 2024-01-30 Florian F. Hildenbrand, Barbara Illi, Stefanie von Felten, Jacqueline Bachofner, Joanna Gawinecka, Arnold von Eckardstein, Beat Müllhaupt, Joachim C. Mertens, Sena Blümel
With the increase in patients at risk of advanced liver disease due to the obesity epidemic, there will be a need for simple screening tools for advanced liver fibrosis. Soluble suppression of tumorigenicity 2 (sST2) is a serum biomarker for fibrotic processes. The aim of this study was to evaluate sST2 as marker for liver fibrosis in patients successfully treated for chronic hepatitis C. 424 patients