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Relationship between four insulin resistance surrogates and left ventricular hypertrophy among hypertensive adults: a case–control study Endocr. Connect. (IF 2.9) Pub Date : 2024-04-01 Yumei Zhai, Haiming Fu, Yu Li, Siyuan Li, Wenchen Zhang, Jianwei Yue, Zichao Wang
Background Hypertension-induced left ventricular hypertrophy (LVH) is intricately linked to insulin resistance (IR). This research aimed to elucidate the relationship of advanced indices, namely the triglyceride–glucose (TyG) index, the TyG adjusted for body mass index (TyG-BMI), the triglycerides-to-high-density lipoprotein cholesterol ratio (TG/HDL-c), and the metabolic score for IR (METS-IR), with
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Risk of cardiovascular disease after hospital-diagnosed overweight or obesity Endocr. Connect. (IF 2.9) Pub Date : 2024-04-01 Sigrid Bjerge Gribsholt, Morten Schmidt, Eskild Bendix Kristiansen, Bjørn Richelsen, Henrik Toft Sørensen
Objective The aim was to examine the association between hospital-diagnosed overweight/obesity and incident CVD according to the time period of the overweight/obesity diagnosis. Design This is a cohort study. Methods From Danish national health registries, we identified all residents with a first-time hospital-based overweight/obesity diagnosis code, 1977–2018 (n = 195,221), and an age and sex-matched
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Association of weight-adjusted waist index and diabetic kidney disease in type 2 diabetes mellitus Endocr. Connect. (IF 2.9) Pub Date : 2024-04-01 Yunyi Ding, Siyao Lv, Ruijie Xie, Wei Ye, Yichen Luo, Yayu Li
Objective The aim of this study was to investigate the relationship between weight-adjusted-waist index (WWI) and diabetic kidney disease in individuals afflicted with type 2 diabetes. Methods Comprehensive data were ascertained from the National Health and Nutrition Examination Survey in 2013–March 2020. Weighted univariate, multivariate logistic regression models, subgroup analyses and tests for
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Growth hormone-secreting pituitary adenoma combined with Graves’ disease: retrospective case series and literature review Endocr. Connect. (IF 2.9) Pub Date : 2024-04-01 Caiyan Mo, Tao Tong, Ying Guo, Zheng Li, Liyong Zhong
Purpose The coexistence of growth hormone-secreting pituitary adenoma (GHPA) and Graves' disease (GD) is rare. This study aimed to investigate the relationship between growth hormone (GH)/insulin-like growth factor 1 (IGF-1) levels and thyroid function in patients with GHPA combined with GD and to explore the underlying mechanisms. Methods Eleven patients with GHPA combined with GD during 2015-2022
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Undiagnosed adrenal insufficiency as a premature cause of death in glucocorticoid users Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Margret Jona Einarsdottir, Penelope Trimpou, Gudmundur Johannsson, Oskar Ragnarsson
Objective: It is unknown whether glucocorticoid (GC)-induced adrenal insufficiency may cause premature mortality in GC-users. We conducted a retrospective cohort study to investigate if undiagnosed and undertreated GC-induced adrenal insufficiency is a contributor to premature death in GC users. Methods: Information on dispensed prescriptions in West Sweden from 2007 to 2014 was obtained from the Swedish
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Chemerin affects blood lipid profile of high-fat diet male mice in sedentary and exercise states via glucose and lipid metabolism enzymes Endocr. Connect. (IF 2.9) Pub Date : 2024-04-01 Yi Jia, Yanan Yang, Jing Qu, Lijun Yin, Xiaohui Wang
Adipokine chemerin plays important roles in disorders of glucose and lipid metabolism of obesity and obesity-related diseases, and exercise-induced improvement of glucose and lipid metabolism is closely related to the decrease of chemerin, but the mechanisms by which chemerin regulates glucose and lipid metabolism remain unclarified. Hypotestosterone induces male obesity and disorders of glucose and
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Bilateral pheochromocytomas: clinical presentation and morbidity rate related to surgery technique and genetic status Endocr. Connect. (IF 2.9) Pub Date : 2024-04-01 Sofia Maria Lider Burciulescu, Monica Livia Gheorghiu, Andrei Muresan, Iuliana Gherlan, Attila Patocs, Corin Badiu
Background Pheochromocytomas (PHEOs) are rare catecholamine-secreting adrenal tumors. Approximately 60–90% of bilateral PHEOs are hereditary. We retrospectively analyzed the clinical characteristics of patients with bilateral PHEOs and the morbidity rate (malignancy, tumor recurrence and adrenal insufficiency (AI) rate) related to surgery technique and genetic status of the patients. Results Fourteen
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The distinct hepatic metabolic profiles and the relations with impaired liver function in congenital isolated growth hormone deficient rats Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Xiaonan Guo, Wenjing Hu, Xiaorui Lyu, Hanyuan Xu, Huijuan Zhu, Hui Pan, Linjie Wang, Hongbo Yang, Gong Fengying
Objective: Patients with growth hormone deficiency (GHD) with inadequate growth hormone levels are often correlated with nonalcoholic fatty liver disease (NAFLD). However, potential mechanism of how GHD influences liver function remains obscure. Thus, we aimed to perform hepatic metabolomics in Lewis dwarf rats, a classical model of isolated GH-deficient rat, to evaluate characterizations of hepatic
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Kaempferol alleviates adipose tissue inflammation and insulin resistance in db/db mice by inhibiting the STING/NLRP3 signaling pathway Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Huiyuan Zhai, Dongxu Wang, Yong Wang, Hongwei Gu, Juan Jv, Liangliang Yuan, Chao Wang, Leiyao Chen
Chronic inflammation induced by obesity plays a crucial role in the pathogenesis of insulin resistance. The infiltration of macrophages into adipose tissues contributes to adipose tissue inflammation and insulin resistance. Kaempferol, a flavonoid present in various vegetables and fruits, has been shown to possess remarkable anti-inflammatory properties. In this study, we used leptin receptor-deficient
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Society for Endocrinology (SfE) guidelines for the diagnosis and management of post bariatric hypoglycaemia Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Jonathan Hazlehurst, Bernard Khoo, Carolina Brito Lobato, Ibiyemi Ilesanmi, Sally Abbott, Tin Chan, Sanesh Pillai, Kate Maslin, Sanjay Purkayastha, Barbara McGowan, Rob Andrews, Tricia M-m. Tan
Post bariatric hypoglycaemia (PBH) is typically a post-prandial hypoglycaemia occurring about 2-4 hours after eating in people who have undergone bariatric surgery. PBH develops relatively late after surgery and often after discharge from post-surgical follow-up by bariatric teams, leading to variability in diagnosis and management in non-specialist centres. Aim: to improve and standardise clinical
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Exercise alleviates renal interstitial fibrosis by ameliorating the Sirt1-mediated TGF-β1/Smad3 pathway in T2DM mice Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Xianghe Chen, Xinyu Zeng, Xiao Qiu, Chi Liu, Pengcheng Lu, Ziming Shen, Xiangxiang Zhou, Kang Yang
Background Renal interstitial fibrosis is the pathophysiological basis of type 2 diabetes mellitus (T2DM). Exercise appears to improve kidney interstitial fibrosis in T2DM, in which silent information regulator factor 2-related enzyme 1 (Sirt1) is a critical regulator. However, the role of Sirt1 in mediating exercise on renal tissue as well as its mechanism remains unknown. Methods T2DM mouse models
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Increased GPC4 and clusterin associated with insulin resistance in patients with PCOS Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Zheng Chen, Haixia Zeng, Qiulan Huang, Cuiping Lin, Xuan Li, Shaohua Sun, Jian-ping Liu
The aim of the study was to investigate the changes in serum glypican 4 (GPC4) and clusterin (CLU) levels in patients with polycystic ovary syndrome (PCOS) as well as their correlation with sex hormones and metabolic parameters. A total of 40 PCOS patients and 40 age-matched healthy women were selected. Serum GPC4 and CLU levels were compared between the PCOS and control groups, and binary logistic
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The effect of exogenous glucagon on circulating amino acids in individuals with and without type 2 diabetes and obesity Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Magnus F G Grøndahl, Jonatan I Bagger, Malte P Suppli, Gerrit Van Hall, Nicolai J W Albrechtsen, Jens J Holst, Tina Vilsbøll, Mikkel B Christensen, Asger B Lund, Filip K Knop
Objective In obesity and type 2 diabetes, hyperglucagonaemia may be caused by elevated levels of glucagonotropic amino acids due to hepatic glucagon resistance at the level of amino acid turnover. Here, we investigated the effect of exogenous glucagon on circulating amino acids in obese and non-obese individuals with and without type 2 diabetes. Design This was a post hoc analysis in a glucagon infusion
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GLP-1 and PYY for the treatment of obesity: a pilot study on the use of agonists and antagonists in diet-induced rats Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Marie Oertel, Christian G Ziegler, Michael Kohlhaas, Alexander Nickel, Simon Kloock, Christoph Maack, Vasco Sequeira, Martin Fassnacht, Ulrich Dischinger
Objective Combination therapies with gut hormone analogs represent promising treatment strategies for obesity. This pilot study investigates the therapeutic potential of modulators of the glucagon-like peptide 1 (GLP-1) and neuropeptide Y (NPY) system using GLP-1 receptor agonists (semaglutide) and antagonists (exendin 9-39), as well as non-selective and NPY-Y2-receptor selective peptide tyrosine tyrosine
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Isolated hypoaldosteronism is a cause of hypovolemic but not euvolemic hyponatremia Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Jorge Gabriel Ruiz-Sánchez, Alfonso Luis Calle-Pascual, Miguel Ángel Rubio-Herrera, María Paz De Miguel Novoa, Emilia Gómez-Hoyos, Isabelle Runkle
Introduction Hypoaldosteronism is characterized by hyperkalemia, and/or hypovolemic hyponatremia (HH), often accompanied by metabolic acidosis. HH is typical of hypoaldosteronism, whereas euvolemic hyponatremia (EH) is not. The purpose of the current study is to describe the characteristics of hyponatremia in hypoaldosteronism and elucidate whether EH can be considered part of the disease’s spectrum
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The impact of mitotane therapy on serum-free proteins in patients with adrenocortical carcinoma Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Magdalena Lech, Ruvini Ranasinghe, Royce P Vincent, David R Taylor, Lea Ghataore, James Luxton, Fannie Lajeunesse-Trempe, Pia Roser, Eftychia E Drakou, Ling Ling Chuah, Ashley B Grossman, Simon J B Aylwin, Georgios K Dimitriadis
Introduction Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex. Whilst surgery is the preferred treatment, adjunctive therapy with mitotane may be offered post-surgically to minimise the risk of recurrence or, in the absence of surgery, to attenuate progression. Aim The objective was to evaluate the effects of mitotane treatment on serum protein concentrations in patients treated
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Heme oxygenase 2 genetic variants alter hormonal and metabolic traits in polycystic ovary syndrome Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Xinyuan Zhang, Suiyan Li, Hongwei Liu, Huai Bai, Qingqing Liu, Chunyi Yang, Ping Fan
Oxidative stress and metabolic disorders are involved in the pathogenesis of polycystic ovary syndrome (PCOS). Heme oxygenase 2 (HMOX2) plays a critical role in preserving heme metabolism as well as in modulating glycolipid metabolism, oxidative stress, and inflammation. This study examined the correlation between HMOX2 G554A (rs1051308) and A-42G (rs2270363) genetic variants with the risk of PCOS
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Update on therapeutic use of levothyroxine for the management of hypothyroidism during pregnancy Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Bogumila Urgatz, Kris G Poppe
Hypothyroidism is a relatively common finding during pregnancy. This may be due either to the presence of existing thyroid disease and/or to the increased demands that pregnancy places the thyroid gland to provide thyroid hormones for the mother and the developing fetus. There is no doubt that overt hypothyroidism is associated strongly with adverse pregnancy outcomes, including miscarriage. Meta-analyses
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Diagnostic performance of ACR-TIRADS combined with superb microvascular imaging for differential diagnosis of mummified thyroid nodules and papillary thyroid carcinomas Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Jiali Tian, Jinlei Liang, Yuhong Lin, Liping Wang, Xiaobo Chen
Objective The aim was to investigate the ability of superb microvascular imaging (SMI) to improve the differential diagnosis of mummified thyroid nodules (MTNs) and papillary thyroid carcinomas (PTCs) using the 2017 American College of Radiology Thyroid Imaging Reporting and Data System (ACR-TIRADS). Materials and methods We enrolled 110 cases of MTNs and 110 cases of PTCs confirmed by fine needle
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The effect of estradiol add-back: a longitudinal MRI study in prostate cancer patients Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Orwa Dandash, James Allebone, Adam Mirabelli, Nicholas Russell, Mathis Grossmann, Andrea Gogos, Richard A Kanaan
We investigated the effect of estradiol add-back therapy (EAT) on brain activation related to cognitive function and affect in addition to putative changes in gray and white matter volume in testosterone depleted participants with prostate cancer. We conducted a randomized controlled, double-blinded trial in which 40 patients received 0.9 mg of transdermal estradiol per day for 6 months or matched
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Effect of BMI on cumulative live birth rates in patients that completed IVF treatment: a retrospective cohort study of 16,126 patients Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Zhou Zheng, Xiuming Zhang, Fanggui Wu, Haizhen Liao, Huan Zhao, Minqi Zhang, Shangjie Liu
Although several studies have reported that high maternal BMI could influence the cumulative live birth rate (CLBR) in fresh embryo transfer cycles, the association of BMI with CLBR remains unclear in patients that completed IVF treatment. In this study, we examined the association of maternal BMI with CLBR, including repetitive one oocyte pick-up (OPU) and all fresh and frozen embryo transfer until
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Factors associated with disease control failure in acromegaly patients treated with pegvisomant: an ACROSTUDY analysis Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Antonella Giampietro, Sabrina Chiloiro, Claudio Urbani, Rosario Pivonello, Martin Ove Carlsson, Francesca Dassie, Nunzia Prencipe, Marta Ragonese, Roy Gomez, Simona Granato, Salvatore Cannavò, Silvia Grottoli, Pietro Maffei, Annamaria Colao, Fausto Bogazzi, Antonio Bianchi
Purpose The aim of this study was to examine the probability of achieving acromegaly disease control according to several patient-, disease- and treatment-related factors longitudinally. Methods We analyzed data from ACROSTUDY, an open-label, noninterventional, post-marketing safety surveillance study conducted in 15 countries. A total of 1546 patients with acromegaly and treated with pegvisomant,
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Pancreas agenesis and fetal growth: a semiquantitative analysis Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Mireille N M van Poppel, Christopher J Nolan, Gernot Desoye
Pancreas agenesis is a rare condition underlying a variant of permanent neonatal diabetes mellitus. Neonates with this condition are born small for gestational age, but less is known about which components of growth are impacted, the timing of the growth restriction and potential sex differences. Our objective was to assess in which periods in gestation complete pancreas agenesis restricts fetal growth
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Identification of potential biomarkers for diabetic cardiomyopathy using LC-MS-based metabolomics Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Run-Qing Xiong, Yan-Ping Li, Lu-Ping Lin, Jeng-Yuan Yao
Diabetic cardiomyopathy (DCM) is a serious complication of type 2 diabetes mellitus (T2DM) that contributes to cardiovascular morbidity and mortality. However, the metabolic alterations and specific biomarkers associated with DCM in T2DM remain unclear. In this study, we conducted a comprehensive metabolomic analysis using liquid chromatography–mass spectrometry (LC-MS) to investigate the plasma metabolite
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Captopril challenge test: an underutilized test in the diagnosis of primary aldosteronism Endocr. Connect. (IF 2.9) Pub Date : 2024-03-01 Sharmin Jahan, Jun Yang, Jinbo Hu, Qifu Li, Peter J Fuller
Primary aldosteronism (PA) is the most common cause of endocrine hypertension and is often underdiagnosed. This condition is associated with increased cardiovascular morbidity and mortality in comparison to age and blood pressure matched individuals with essential hypertension (EH). The diagnostic pathway for PA consists of three phases: screening, confirmatory testing, and subtyping. The lack of specificity
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Performance of renin assays in selecting fludrocortisone dose in children with adrenal disorders Endocr. Connect. (IF 2.9) Pub Date : 2024-02-01 Timothy J Morris, Andrew Whatmore, Laura Hamilton, Beverly Hird, Eric S Kilpatrick, Lesley Tetlow, Peter Clayton
Children with salt-wasting adrenal insufficiency are managed with glucocorticoid and mineralocorticoid replacement. Measurement of renin activity or concentration alongside blood electrolyte levels is used to monitor the adequacy of mineralocorticoid replacement. Our unit changed from using renin activity to renin concentration and carried out a service review to assess whether this influenced decision-making
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Comparisons of clinical outcomes between newly diagnosed early- and late-onset T2DM: a real-world study from the Shanghai Hospital Link Database Endocr. Connect. (IF 2.9) Pub Date : 2024-02-01 Xinge Tao, Yanbin Xue, Rui Niu, Wenjing Lu, Huayan Yao, Chunmei He, Bin Cui, Changqin Liu
Objective The aim of this study was to compare the differences in incident population, comorbidities, and glucose-lowering drug prescriptions between newly diagnosed patients with early-onset type 2 diabetes mellitus (T2DM) and those with late-onset T2DM to provide real-world evidence for clinical practice. Methods This study was based on the Shanghai Hospital Link Database (SHLD). Anonymized electronic
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The prognostic power of gene mutations in thyroid cancer Endocr. Connect. (IF 2.9) Pub Date : 2024-02-01 Sara Ahmadi, Iñigo Landa
The introduction and generalization of next-generation sequencing techniques have significantly increased the identification of mutations in thyroid tumors from multiple patient cohorts. The understanding of the association between specific mutations and clinical outcomes is gradually leading to individualizing the care of patients with thyroid cancer. BRAFV600 is the most common mutation seen in thyroid
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Ultrasound combined with Ki-67 to construct the prognostic model for radioactive iodine therapy outcomes in Graves’ disease patients Endocr. Connect. (IF 2.9) Pub Date : 2024-02-01 Yuegui Wang, Liwei Hong, Caiyun Yang, Guorong Lv, Kangjian Wang, Xuepeng Huang, Haolin Shen
The aim of this study was to develop a prognostic model for radioactive iodine (RAI) therapy outcome in patients with Graves‘ disease. We enrolled 127 patients. Information on RAI therapy, ultrasound indexes of thyroid, and other lifestyle factors was collected. The competing risk model was used to estimate the multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for nonhealing
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Pituitary dysfunction following mild traumatic brain injury in female athletes Endocr. Connect. (IF 2.9) Pub Date : 2024-02-01 Lára Ósk Eggertsdóttir Claessen, Hafrún Kristjánsdóttir, María Kristín Jónsdóttir, Sigrún Helga Lund, Ingunn Unnsteinsdóttir Kristensen, Helga Ágústa Sigurjónsdóttir
Objective Pituitary dysfunction following mild traumatic brain injury can have serious physical and psychological consequences, making correct diagnosis and treatment essential. To the best of our knowledge, this study is the first to study the prevalence of pituitary dysfunction following mild traumatic brain injury in an all-female population following detailed endocrinological work-up after screening
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Endometriosis, polycystic ovary syndrome, and the thyroid: a review Endocr. Connect. (IF 2.9) Pub Date : 2024-02-01 Signe Kirkegaard, Nanna Maria Uldall Torp, Stig Andersen, Stine Linding Andersen
Endometriosis and polycystic ovary syndrome (PCOS) are common gynecological disorders that constitute a significant burden of disease in women of fertile age. The disorders share a link to female reproduction and infertility; however, divergent effects on menstrual cycle, related hormones, and body composition have been proposed. Disorders of the thyroid gland including abnormal thyroid dysfunction
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Shift work and evening chronotype are associated with hepatic fat fraction and non-alcoholic fatty liver disease in 282,303 UK biobank participants Endocr. Connect. (IF 2.9) Pub Date : 2024-02-01 Robert Maidstone, Martin K Rutter, Thomas Marjot, David W Ray, Matthew Baxter
Background and aims Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common liver disease worldwide. Modern lifestyles have been linked to this rise in prevalence with changes in rhythmic human behaviour emerging as a possible mechanism. We investigated how shift working patterns and chronotype were associated with hepatic fat fraction and NAFLD in 282,303 UK Biobank participants
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Fertility and pregnancy in adrenal insufficiency Endocr. Connect. (IF 2.9) Pub Date : 2024-02-01 Deirdre Green, Rosemary Dineen, Michael W O’Reilly, Mark Sherlock
Despite the availability of adrenal hormone replacement therapy, patients with adrenal insufficiency can be affected by reduced fertility and parity. Patients with well-managed adrenal insufficiency are expected to have uneventful pregnancies and favourable outcomes, but an increased risk of maternal and neonatal complications has been reported in some cases. Many physiological changes occur to the
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Clinical significance of CYP11B2 immunostaining in unilateral primary aldosteronism Endocr. Connect. (IF 2.9) Pub Date : 2024-02-01 Marianna Viukari, Helena Leijon, Tiina Vesterinen, Sanni Söderlund, Päivi Hämäläinen, Iina Yliaska, Päivi Rautiainen, Reeta Rintamäki, Minna Soinio, Ilkka Pörsti, Pasi I Nevalainen, Niina Matikainen
Objective The associations between adrenal histopathology, lateralization studies, and surgical outcomes in primary aldosteronism remain poorly characterized. We examined the value of immunohistochemical analysis of CYP11B2 for evaluation of adrenalectomy outcomes after anatomical versus functional subtyping. Design A retrospective multicenter study of 277 patients operated for primary aldosteronism
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The value of plasma metanephrine measurements during adrenal vein sampling Endocr. Connect. (IF 2.9) Pub Date : 2024-02-01 Richard W Carroll, Brian Corley, Joe Feltham, Patricia Whitfield, William Park, Rowena Howard, Melissa Yssel, Ian Phillips, Simon Harper, Jun Yang
Objective The assessment of primary aldosteronism incorporates adrenal vein sampling (AVS) to lateralize aldosterone excess. Current adrenal vein sampling protocols rely on concurrent cortisol measurements to assess successful cannulation and lateralization and may be inaccurate in the setting of autonomous cortisol secretion. We aimed to compare the measurement of plasma cortisol and metanephrine
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A review of CONCEPTT study findings including subanalyses in pregnant women using continuous glucose monitoring with type 1 diabetes and their offspring Endocr. Connect. (IF 2.9) Pub Date : 2024-02-01 David Q Pham, Ashley Thorsell, Kristin Castorino, Brandon Cobb
The main objective of this article is to provide a comprehensive review of continuous glucose monitor (CGM) use in pregnant women with type 1 diabetes (T1D) from the CONCEPTT study including subanalyses. Literature search was accessed through MEDLINE (1966–September 2023) using the key terms: CONCEPTT, pregnancy, women, T1D, and CGM with limitations set to distinguish human subjects written in English
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Association of vitamin D levels with anthropometric and adiposity indicators across all age groups: a systematic review of epidemiologic studies Endocr. Connect. (IF 2.9) Pub Date : 2024-02-01 Behnaz Abiri, Majid Valizadeh, Amirhossein Ramezani Ahmadi, Shirin Amini, Mohammad Nikoohemmat, Faeze Abbaspour, Farhad Hosseinpanah
Objectives It has not been established whether vitamin D deficiency is associated with anthropometric state; therefore, this systematic review examined the relationship between serum vitamin D levels with anthropometrics and adiposity across different ages. Methods Studies that examined vitamin D deficiency with adiposity measures in different age groups were searched in the PubMed, Scopus, Embase
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Cognitive performance during senescence in untreated congenital isolated GH deficiency Endocr. Connect. (IF 2.9) Pub Date : 2024-01-01 Vanderlan O Batista, Michael Kellner, Roberto Salvatori, Walter Lisboa, André Faro, Lucas B Santos, Enaldo V Melo, Alécia A Oliveira-Santos, Carla R P Oliveira, Viviane C Campos, Cynthia S Barros-Oliveira, Elenilde G Santos, Nathalie O Santana, Keila R Villar-Gouy, Ângela C Leal, Rivia S Amorim, Davi A Oliveira Simões, Manuel H Aguiar-Oliveira
Individuals with untreated isolated GH deficiency (IGHD) due to a mutation in the GHRH receptor gene from Itabaianinha Brazil have increased insulin sensitivity, normal life expectancy, and an extended health span, i.e. the period of life free from disabilities. We hypothesize that their prolonged health span is accompanied by a delayed cognitive decline in senescence. To test this hypothesis, we have
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Sex steroid levels in corresponding cerebrospinal fluid and serum samples quantified by mass spectrometry in men Endocr. Connect. (IF 2.9) Pub Date : 2024-01-01 Henrik Ryberg, Anna-Karin Norlén, Andreas Landin, Per Johansson, Zeinab Salman, Anders Wallin, Johan Svensson, Claes Ohlsson
Objective Sex steroids exert important biological functions within the CNS, but the underlying mechanisms are poorly understood. The contribution of circulating sex steroids to the levels in CNS tissue and cerebrospinal fluid (CSF) has been sparsely investigated in human and with inconclusive results. This could partly be due to lack of sensitive validated assays. To address this, we validated a gas
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LRG1 predicts the prognosis and is associated with immune infiltration in thyroid cancer: a bioinformatics study Endocr. Connect. (IF 2.9) Pub Date : 2024-01-01 Zherui Fu, Yi Lai, Qianfei Wang, Feng Lin, Jiaping Fang
Background The diagnostic and prognostic value of the leucine-rich alpha-2-glycoprotein 1 (LRG1) gene in thyroid cancer remains unclear. Using the Cancer Genome Atlas (TCGA) database, we conducted a bioinformatics analysis to determine the role of LRG1 in thyroid cancer. Methods Data from 512 patients with thyroid cancer and 59 normal individuals were collected from TCGA database. The Kruskal–Wallis
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PLK1 inhibitors as a new targeted treatment for adrenocortical carcinoma Endocr. Connect. (IF 2.9) Pub Date : 2024-01-01 Emily Warmington, Gabrielle Smith, Vasileios Chortis, Raimunde Liang, Juliane Lippert, Sonja Steinhauer, Laura-Sophie Landwehr, Constanze Hantel, Katja Kiseljak-Vassiliades, Margaret E Wierman, Barbara Altieri, Paul A Foster, Cristina L Ronchi
Adrenocortical carcinoma (ACC) is an aggressive malignancy with limited treatment options. Polo-like kinase 1 (PLK1) is a promising drug target; PLK1 inhibitors (PLK1i) have been investigated in solid cancers and are more effective in TP53-mutated cases. We evaluated PLK1 expression in ACC samples and the efficacy of two PLK1i in ACC cell lines with different genetic backgrounds. PLK1 protein expression
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Mfn2 regulates mitochondria-associated ER membranes to affect PCOS oocyte development Endocr. Connect. (IF 2.9) Pub Date : 2024-01-01 Xiuhua Liao, Suqin Zhu, Shumin Qiu, Hua Cao, Wenwen Jiang, Huiling Xu, Yan Sun, Beihong Zheng
This study aimed to investigate the role of mitochondrial-related protein Mfn2 in polycystic ovary syndrome (PCOS) and its impact on oocyte development. The pathological features of PCOS model mice were confirmed by hematoxylin–eosin staining and immunohistochemistry. The expression of Mfn2 and mitochondrial-related proteins in PCOS oocytes and granulosa cells was detected by qRT-PCR and Western blot
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Association of serum 25-hydroxyvitamin D levels with aggressiveness of papillary thyroid cancer Endocr. Connect. (IF 2.9) Pub Date : 2024-01-01 Yuting Shao, Xiaole Hu, Yuxi Wang, Yi Shao, Luchuan Li, Qingdong Zeng, Hong Lai, Lei Sheng
Objective Serum 25-hydroxyvitamin D (25(OH)D) deficiency has been known to be associated with the risk and mortality of several cancers. However, the role of 25(OH)D in papillary thyroid cancer (PTC) remains controversial. This study aimed to investigate the association between 25(OH)D and clinicopathologic features of PTC. Methods Patients who underwent thyroidectomy were retrospectively reviewed
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The significance of short-term preoperative calcium and activated vitamin D3 supplementation in thyroidectomy: a randomized trial and prospective study Endocr. Connect. (IF 2.9) Pub Date : 2024-01-01 Xiaoli Jin, Jiankang Shen, Tao Liu, Ru Zhou, Xunbo Huang, Tianxiang Wang, Weize Wu, Mingliang Wang, Rongli Xie, Jianming Yuan
Objective The aim was to explore the effects of preoperative calcium and activated vitamin D3 supplementation on post-thyroidectomy hypocalcemia and hypo-parathyroid hormone-emia (hypo-PTHemia). Methods A total of 209 patients were randomly divided into control group (CG) and experimental group (EG). Oral calcium and activated vitamin D3 supplementation were preoperatively administered to EG, whereas
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Age- and sex-adjusted reference intervals for steroid hormones measured by liquid chromatography–tandem mass spectrometry using a widely available kit Endocr. Connect. (IF 2.9) Pub Date : 2024-01-01 Sonja Kunz, Xiao Wang, Uta Ferrari, Michael Drey, Marily Theodoropoulou, Katharina Schilbach, Martin Reincke, Margit Heier, Annette Peters, Wolfgang Koenig, Tanja Zeller, Barbara Thorand, Martin Bidlingmaier
Objective Measurements utilizing commercially available sets of reagents for determination of steroid hormone profiles by liquid chromatography–tandem mass spectrometry (LC-MS/MS) have become increasingly important for routine laboratories. However, method-specific publications of reference intervals obtained from sufficiently large studies are often missing. Methods After validation of performance
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Hyperglucagonaemia and amino acid alterations in individuals with type 2 diabetes and non-alcoholic fatty liver disease Endocr. Connect. (IF 2.9) Pub Date : 2024-01-01 Iben Rix, Marie L Johansen, Asger Lund, Malte P Suppli, Elizaveta Chabanova, Gerrit van Hall, Jens J Holst, Nicolai J Wewer Albrechtsen, Caroline Kistorp, Filip K Knop
Aims Hyperglucagonaemia contributes to the pathophysiology in type 2 diabetes (T2D), but the mechanisms behind the inappropriate glucagon secretion are not fully understood. Glucagon and amino acids are regulated in a feedback loop referred to as the liver–α cell axis. Individuals with non-alcoholic fatty liver disease (NAFLD) appear to be glucagon resistant, disrupting the liver–α cell axis resulting
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Epidemiologic trends of and factors associated with overall survival in patients with neuroendocrine tumors over the last two decades in the USA Endocr. Connect. (IF 2.9) Pub Date : 2023-12-01 Peiwen Wu, Dongjie He, Hao Chang, Xiaozhi Zhang
Background Updated epidemiological data of neuroendocrine tumors are currently lacking. Thus, we performed epidemiological and survival analyses on a large cohort of patients with neuroendocrine tumors and developed a new nomogram to predict survival. Methods This population-based study examined 112,256 patients with neuroendocrine tumors between 2000 and 2018 using data from the Surveillance, Epidemiology
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17β-hydroxysteroid dehydrogenase type 1 improves survival in serous epithelial ovarian tumors Endocr. Connect. (IF 2.9) Pub Date : 2023-12-01 Enrique Pedernera, Flavia Morales-Vásquez, María J Gómora, Miguel A Almaraz, Esteban Mena, Delia Pérez-Montiel, Elizabeth Rendon, Horacio López-Basave, Juan Maldonado-Cubas, Carmen Méndez
The incidence of ovarian cancer has been epidemiologically related to female reproductive events and hormone replacement therapy after menopause. This highlights the importance of evaluating the role of sexual steroid hormones in ovarian cancer by the expression of enzymes related to steroid hormone biosynthesis in the tumor cells. This study was aimed to evaluate the presence of 17β-hydroxysteroid
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Value of circulating neutrophil elastase for detecting recurrence of differentiated thyroid cancer Endocr. Connect. (IF 2.9) Pub Date : 2023-12-01 Hyunjae Lee, Tae-Shin Kim, Ja-Yoon Gu, Mi Ran Yu, Seung-Eun Lee, Eun Sook Kim, Hyun Kyung Kim
Objective The inflammatory microenvironment has been implicated in differentiated thyroid cancer (DTC). Inflammatory stimuli induce the release of components of neutrophils into extracellular space, leading to formation of neutrophil extracellular trap (NET), which can stimulate growth and progression of cancer. Generation of activated factor XII and thrombin is also involved in cancer progression
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Electronic reporting of rare endocrine conditions within a clinical network: results from the EuRRECa project Endocr. Connect. (IF 2.9) Pub Date : 2023-12-01 S R Ali, J Bryce, A L Priego-Zurita, M Cherenko, C Smythe, T M de Rooij, M Cools, T Danne, H Katugampola, O M Dekkers, O Hiort, A Linglart, I Netchine, A Nordenstrom, P Attila, L Persani, N Reisch, A Smyth, Z Sumnik, D Taruscio, W E Visser, A M Pereira, N M Appelman-Dijkstra, S F Ahmed
Objective The European Registries for Rare Endocrine Conditions (EuRRECa, eurreb.eu) includes an e-reporting registry (e-REC) used to perform surveillance of conditions within the European Reference Network (ERN) for rare endocrine conditions (Endo-ERN). The aim of this study was to report the experience of e-REC over the 3.5 years since its launch in 2018. Methods Electronic reporting capturing new
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Lipidomics analysis of impaired glucose tolerance and type 2 diabetes mellitus in overweight or obese elderly adults Endocr. Connect. (IF 2.9) Pub Date : 2023-12-01 Feifei Shao, Xinxin Hu, Jiayu Li, Bona Bai, Limin Tian
Aims Aging, obesity, and type 2 diabetes mellitus (T2DM) form a metabolic disease continuum that has a continuously increasing prevalence. Lipidomics explains the complex interactions between lipid metabolism and metabolic diseases. We aimed to systematically investigate the plasma lipidome changes induced by newly diagnosed impaired glucose tolerance (IGT) and T2DM in overweight/obese elderly individuals
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Perinatally diagnosed congenital craniopharyngiomas in the KRANIOPHARYNGEOM trials Endocr. Connect. (IF 2.9) Pub Date : 2023-12-01 Julia Beckhaus, Svenja Boekhoff, Katrin Scheinemann, Freimut H Schilling, Gudrun Fleischhack, Gerhard Binder, Brigitte Bison, Torsten Pietsch, Carsten Friedrich, Hermann L Müller
Background Craniopharyngiomas (CPs) are rare embryonic tumors. Clinical presentation and outcome of patients perinatally diagnosed with congenital CP (cCP) are not clear and refer mainly to a few case reports in the literature. The aim of this study was to analyze clinical presentation and outcome in patients with cCP. Study design Three hundred and sixty-one patients diagnosed with adamantinomatous
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Characteristics of cardiac arrhythmia and heart rate variability in Chinese patients with primary aldosteronism Endocr. Connect. (IF 2.9) Pub Date : 2023-12-01 Shuang Wan, Chengcheng Zheng, Tao Chen, Lu Tan, Jia Tang, Haoming Tian, Yan Ren
We applied 24-h Holter monitoring to analyze the characteristics of arrhythmias and heart rate variability in Chinese patients with primary aldosteronism (PA) and compared them with age-, sex-, and blood pressure-matched primary hypertension (PH) patients. A total of 216 PA patients and 261 PH patients were enrolled. The nonstudy data were balanced using propensity score matching (PSM), and the risk
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Hyperthyroidism incidence in a large population-based study in northeastern Italy Endocr. Connect. (IF 2.9) Pub Date : 2023-12-01 Simona Censi, Laura Salmaso, Filippo Ceccato, Jacopo Manso, Ugo Fedeli, Mario Saia, Caterina Mian
Objective An improvement in iodine status in Veneto Region has been documented in the last decade. We aimed at estimating the incidence of hyperthyroidism in the Veneto Region (Italy) over the period 2013–2022. Methods Retrospective population-based study conducted in Veneto (4.9 million people) using the population registry, an administrative health database. Between 2012 and 2022, hyperthyroidism
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The effect of radioactive iodine treatment for differentiated thyroid cancer on male gonadal function: a meta-analysis Endocr. Connect. (IF 2.9) Pub Date : 2023-12-01 Yanling Cai, Yan Yang, Xiao Pang, Suping Li
Purpose The aim was to investigate the effect of radioactive iodine (RAI) treatment for differentiated thyroid cancer (DTC) on male gonadal function. Methods PubMed, Embase, Web of Science, OVID, Scopus, and Wanfang databases were searched up to June 10, 2022, to identify published studies related to RAI and male gonadal function. ReviewManager version 5.4.1 software was used to calculate mean differences
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Severe hypernatremia during postoperative care in patients with craniopharyngioma Endocr. Connect. (IF 2.9) Pub Date : 2023-12-01 Lingjuan Li, Jing Qin, Lin Ren, Shiyuan Xiang, Xiaoyun Cao, Xianglan Zheng, Zhiwen Yin, Nidan Qiao
Purpose We aimed to describe and predict the risk of severe hypernatremia after surgical resection of craniopharyngioma and to identify the association of water intake, urine output, and sodium level change in the patients. Method The outcome was postoperative severe hypernatremia. We identified risk factors associated with hypernatremia using multivariable regression. We trained machine learning models
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Evaluation of the correlation between fetuin-B levels and essential hypertension: a cross-sectional study Endocr. Connect. (IF 2.9) Pub Date : 2023-12-01 Tao Gao, Rui Liu, Chunli Li, Xinglin Chu, Qiao Guo, Dazhi Ke
Background Fetuin-B, a cytokine that regulates lipid metabolism, has recently been linked to cardiovascular diseases such as coronary heart disease. In this study, we discussed the relationship between fetuin-B and essential hypertension. Method A bioinformatics analysis of fetuin-B was performed. A total of 206 with essential hypertension and 180 age- and-sex-matched healthy subjects were enrolled
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Hypothyroidism, comorbidity and health-related quality of life: a population-based study Endocr. Connect. (IF 2.9) Pub Date : 2023-12-01 Hanneke J C M Wouters, Bruce H R Wolffenbuttel, Anneke C Muller Kobold, Thera P Links, Gerwin Huls, Melanie M van der Klauw
Hypothyroidism is associated with a decreased health-related quality of life (HRQoL). We hypothesized that individuals with hypothyroidism (defined as use of thyroid hormone (TH)) and especially those having an impaired HRQoL are characterized by a high prevalence of comorbid disorders and that the impact of hypothyroidism and comorbidity on HRQoL is synergistic. Presence of comorbidity was based on
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Salivary androgens in adolescence and their value as a marker of puberty: results from the SCAMP cohort Endocr. Connect. (IF 2.9) Pub Date : 2023-12-01 Supitcha Patjamontri, Alexander Spiers, Rachel B Smith, Chen Shen, Jo Adaway, Brian G Keevil, Mireille B Toledano, S Faisal Ahmed
Context Salivary androgens represent non-invasive biomarkers of puberty that may have utility in clinical and population studies. Objective To understand normal age-related variation in salivary sex steroids and demonstrate their correlation to pubertal development in young adolescents. Design, setting and participants School-based cohort study of 1495 adolescents at two time points for collecting
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Influence of autonomous cortisol secretion in patients with primary aldosteronism: subtype analysis and postoperative outcome Endocr. Connect. (IF 2.9) Pub Date : 2023-12-01 Kuang Hung, Bo-Ching Lee, Po-Ting Chen, Kao-Lang Liu, Chin-Chen Chang, Vin-Cent Wu, Yen-Hung Lin
Context Autonomous cortisol secretion (ACS) has a relatively high prevalence in patients with primary aldosteronism (PA). There is still a lack of relevant studies to analyze the influence of ACS on diagnosing and managing PA. Objective To evaluate the influence of ACS on image–adrenal venous sampling (AVS) correlation and the postoperative results. Methods This was a retrospective study using the