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Research Progress of Risk Factors Associated with Gestational Diabetes Mellitus Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-03-11 Zi-Jun Lin, Lian-Ping He, Cui-Ping Li
: Gestational Diabetes Mellitus (GDM) is a common endocrine condition associated with adverse pregnancy outcomes. In recent years, a growing number of risk factors associated with gestational diabetes mellitus have been defined. GDM poses a serious threat to maternal health. The etiology is complex and multifactorial and can be divided into inherent and modifiable factors. The inherent factors have
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Mediterranean Lifestyle: More Than a Diet, A Way of Living (and Thriving) Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-03-01 Mehdi Kushkestani, Mahsa Moghadassi, Labros Sidossis
: Although the Mediterranean Diet (MedDiet) may appear simple and locally inspired based on the provided definitions, mounting evidence reveals that adopting a dietary pattern aligned with MedDiet principles can yield numerous health benefits. Also, the MedDiet stands as the gold standard in preventive medicine, so it is not a simplistic diet centered around specific ingredients or cooking methods;
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Improving Type 2 Diabetes Care with Extended-Release Metformin: Real-Life Insights from a Physician Educational Program Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-03-01 Laura Molteni, Giuseppe Marelli, Giona Castagna, Luciano Brambilla, Maurizio Acerbis, Fabio Alberghina, Antonio Carpani, Erika Chiavenna, Maria Grazia Ferlini, Carmen Impellizzeri, Roberto Paredi, Alberto Rigamonti, Giuseppe Rivolta, Olga Eugenia Disoteo
Background: Compared to Immediate-Release (IR) metformin, Extended-Release (ER) metformin reduces side effects and pill burden while improving adherence; however, there is little real-life data on patient satisfaction with this innovative formulation to guide physicians toward a more holistic approach. Objective: Our goal is to train general practitioners on holistic patient management, with the aim
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Inhibition of MiR-155 Using Exosomal Delivery of Antagomir Can Up-Regulate PTEN in Triple Negative Breast Cancer Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-03-01 Javad Razaviyan, Majid Sirati-Sabet, Ali Tafti, Razie Hadavi, Saeed Karima, Masoumeh Rajabibazl, Samira Mohammadi-Yeganeh
Background:: The most aggressive form of breast cancer (BC) is Triple-Negative BC (TNBC), with the poorest prognosis, accounting for nearly 15% of all cases. Since there is no effective treatment, novel strategies, especially targeted therapies, are essential to treat TNBC. Exosomes are nano-sized microvesicles derived from cells and transport various intracellular cargoes, including microRNAs (miRNAs)
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Gender Differences in the Predictive Value of Obesity Indices for Insulin Resistance in Adult Mexican Individuals Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-28 Elizalde-Barrera Cesar Ivan, Estrada-Garcia Teresa, Lopez-Saucedo Catalina, Rubio-Guerra Alberto Francisco, Ramirez-Velasco Diana Elena
Background: Obesity-linked insulin resistance (IR) is an important risk factor for metabolic diseases, and anthropometric indices are commonly used for risk assessment. background: Background. Obesity-linked Insulin Resistance (IR) is an important risk factor for metabolic diseases, and anthropometric indices are commonly used for risk assessment. Aim: The study aimed to assess possible differences
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Neglected Adrenal Hypoplasia Congenita in Two Siblings with Novel Genetic Mutations in NR0B1 Gene and Notable Clinical Course: A Case Report Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-27 Shayesteh Khalili, Anahita Zakeri, Farzad Hadaegh, Seyed Saeed Tamehri Zadeh
Background: Adrenal Hypoplasia Congenita (AHC) is a rare subtype of primary adrenal insufficiency (PAI) that can go undiagnosed easily. In this article, we report two brothers with hypogonadotropic hypogonadism and novel mutations in the NR0B1 gene who were misdiagnosed and mismanaged as having congenital adrenal hypoplasia (CAH) for several years. Case Presentation: Herein, we describe two brothers
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Molecular Targets of Valeric Acid: A Bioactive Natural Product for Endocrine, Metabolic, and Immunological Disorders Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-20 Bindu Kumari, Usha Kumari, Dhananjay Kumar Singh, Gulam Mohammad Husain, Dinesh Kumar Patel, Anshul Shakya, Ravi Bhushan Singh, Gyan Prakash Modi, Gireesh Kumar Singh
Backgrounds: Postbiotics produced by gut microbiota have exhibited diverse pharmacological activities. Valeric acid, a postbiotic material produced by gut microbiota and some plant species like valerian, has been explored to have diverse pharmacological activities. Methods: This narrative review aims to summarise the beneficial role of valeric acid for different health conditions along with its underlying
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Endocrine Adverse Events Related To Immune Checkpoint Inhibitor Treatment: Relationship Between Antibodies and Severity of Thyroid Dysfunction Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-16 María Miguélez González, Alba Galdón Sanz-Pastor, Roberto Áñez Gómez, Noemi Brox Torrecilla, Diego Muñoz Moreno, Laura González Fernández, Alejandra Maricel Rivas, Aurelio López Guerra, Rosa Álvarez, José Ángel Arranz, Iván Márquez Rodas, Vicente Escudero, María Sanjurjo, Javier Martín Vallejo, Miguel Martín, Olga González Albarrán
Objective: The purpose of this study was to identify predictive and risk factors for the development of immune-related endocrinopathies and to analyze the incidence and characteristics of immune-related endocrinopathies in our population Design: A retrospective, single-centre cohort carried out at Gregorio Marañón Hospital between January 2018 -December 2019. Methods: A total of 163 patients were enrolled
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Novel Finding of Micropenis Caused by Mutation of the ADGRG2 Gene: A Case Report and Literature Review Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-16 Yiling Cui, Ningyi Song, Ling Hou
Background: This study reported a case of micropenis caused by a novel hemizygous mutation in the ADGRG2 gene, which aimed to expand the understanding of sexual dysplasia caused by ADGRG2 gene mutation. Case Presentation: We present the clinical data and genetic test results of a patient with micropenis admitted in September, 2022, to the Tongji Hospital. The patient was a 9-year-10- month-old male
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Thymus as Incontrovertible Target of Future Immune Modulatory Therapeutics Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-13 Ghulam Jilany Khan, Abeeha Imtiaz, Wei Wang, Hong Duan, Hui Cao, Kefeng Zhai, Nongyue He
: Thymus plays a crucial role in cellular immunity by acting as a warehouse for proliferating and differentiating lymphocytes. Thymic stromal cells educate T-cells to differentiate self from non-self antigens while nurse cells and thymoproteasome play a major role in the maturation and differentiation of T-cells. The thymic conditions dictate T-cells to cope with the risk of cancer development. A study
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Bioinformatics-based Identification of Ferroptosis-Related Genes and their Diagnostic Value in Gestational Diabetes Mellitus Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-13 Xiaomei Lv, Yujun An
Background: Gestational diabetes mellitus (GDM) is considered a risk factor for heart metabolic disorder in future mothers and offspring. Ferroptosis is a new type of programmed cell death, which may participate in the occurrence and development of GDM. Objective: This study aims to identify ferroptosis-related genes in GDM by bioinformatics methods and to explore their clinical diagnostic value. Methods:
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The Recommendation of the Mediterranean-styled Japanese Diet for Healthy Longevity Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-12 Kazuki Santa, Yoshio Kumazawa, Kenji Watanabe, Isao Nagaoka
Background:: The Mediterranean diet, listed as the intangible cultural heritage of humanity by UNESCO, is known as healthy and consumed worldwide. The Japanese diet is also listed and considered healthy. This narrative review compares the Mediterranean diet with its Japanese counterpart. Discussion:: Research has reported that people in Mediterranean regions, such as Italy and Greece, have one-third
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A Systematic Narrative Review on ADIPOQ Gene Variants and its Association with T2DM in the Indian Population Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-09 Mohd. Danish Khan, Rohit Kumar Srivastava, Tarun Kumar Upadhyay, Mohammad Mustufa Khan
Background:: The prevalence of diabetes is rapidly increasing in India, even among young adult individuals. Rare adiponectin gene (ADIPOQ) variants may be predominantly present in Indians and decrease the circulatory levels of APN (Adiponectin). Studies reported that ADIPOQ gene variants were associated with type 2 diabetes mellitus (T2DM) and its complications in the Indian population. Objectives::
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A Case of Intractable Hypophosphatemia in a Patient with Guillain-Barré Syndrome and Encephalitis after SARS-CoV-2 Infection Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-05 Yawen Zheng, Yuanyuan Hou, Mingzhu Qi, Yongxiang Zhang, Chao Han, Hui Sun, Jiang Li
Background:: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection attacks the respiratory and nervous systems. Among patients with SARS-CoV-2 infection, cases with simultaneous central and peripheral nervous system damage are rare, and those with intractable hypophosphatemia and hypokalemia complicating the former have not been reported yet. Case Presentation:: A 59-year-old woman
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Comorbidity, Eating Behaviors and Smartphone Addiction in Italian Nurses’ Characteristics Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-03 Elsa Vitale, Rocco Mea
Background: Evidence suggested how nurses experienced worse lifestyles than the general population by recording deterioration rates in healthy conditions. Aim: To assess differences between comorbidity, eating behavior, and smartphone addiction according to sex, Body Mass Index (BMI), age, work experience, shift, alcohol assumption, and physical activity in Italian nurses. Methods: An online questionnaire
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Pancreas as an Unusual Metastatic Site of Medullary Thyroid Carcinoma: A Case of Very Long-term Follow-up Under Prolonged Treatment with Somatostatin Analogues Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-03 Salvatore Raia, Sabrina Chiloiro, Antonella Giampietro, Maria Grazia Maratta, Fabia Attili, Maria Gabriella Brizi, Vittoria Rufini, Laura De Marinis, Alfredo Pontecorvi, Guido Rindi, Giovanni Schinzari, Antonio Bianchi
Background: Pancreatic metastases from medullary thyroid carcinoma (MTC) are exceptional. Imaging and treatment based on somatostatin receptors may play a role, though the evidence is unconvincing. Case Presentation: We have, herein, documented a unique case of metastatic MTC, where pancreatic metastasis was identified by 68Ga-PET/CT, with the disease showing very slow progression during treatment
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Alterations in CD4+ T Cell Cytokines Profile in Female Patients with Hashimoto’s Thyroiditis Following Vitamin D Supplementation: A Double-blind, Randomized Clinical Trial Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-03 Reza Chahardoli, Behrouz Robat-Jazi, Fereidoun Azizi, Atieh Amouzegar, Davood Khalili, Azita Zadeh-Vakili, Fatemeh Mansouri, Ali Akbar Saboor-Yaraghi
Background: Hashimoto's thyroiditis (HT) is an autoimmune disease characterized by the destruction of thyroid cells through immune processes involving T helper (Th)1 cytokines. This clinical trial investigates the impact of vitamin D supplementation on serum cytokine levels and gene expression in CD4+ T cells from HT patients, aiming to understand its effects on Th-1, Th-2, Th-17, and regulatory T
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Sulphur Amino Acids: How Important is it to Set Reference Ranges for Each Population? Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-03 Helena Caldeira Araújo, Cristina Florindo, Alexandra Gomes, João Caio, Rita Castro, Isabel Rivera
Introduction: Metabolism of sulfur amino acids requires an optimal interplay between nutritional demand, enzymes, transporters, and adequate dietary intake of B vitamins. Insufficient intake and excess are detrimental, and concentrations depend on health status. However, plasma aminothiol concentrations, previously reported in healthy subjects using highly sensitive methods, vary considerably, and
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Highlights from the Top 100 Most Influential Articles Regarding the Nuclear Receptor PPAR-γ: A Bibliometric Analysis Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-03 Si Wu, Haijiao Dai, Xianxiang Bai, Zhen Wu, Xianglei Wang, Bin Xiao
Background: PPAR-γ is one of three members of the PPAR group of the nuclear receptor superfamily and plays an important regulatory role as a ligand-dependent transcription factor. Objective: This study aimed to identify the top 100 most influential articles in the field of PPAR-γ. We hypothesized that a bibliometric and scientometric analysis of the PPAR-γ research field could render trends that provide
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Study of MicroRNA-124 in Patients with Lupus Nephritis Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-03 Mostafa Abdelsalam, Maysaa El Sayed Zaki, Nermin Youssef Abo El-Kheir, Mona Foda Salama, Asmaa Osama Bakr Seddik Osman
Background: Lupus nephritis is associated with a six-fold increase in mortality compared with the general population. MicroRNAs studies revealed that increased MicroRNA -21 and MicroRNA -155 levels represent risk factors for active LN patients. MicroRNAs can be used as biomarkers in the diagnosis of clinical stages of LN. Objectives: The present study aimed to determine the level of miR-124 in patients
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Yiqi Jiedu Xiaoying Decoction Improves Experimental Autoimmune Thyroiditis in Rats by Regulating Th17/Treg Cell Balance Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-03 Hui Zhu, Shumin Mu, Shiyin Liu, Yang Cui, Jianyu Ren, Enquan Yang, Lining Wang, Xiaoke Cui, Ailing Ren
Background: Experimental autoimmune thyroiditis (EAT) is a widely used animal model to study the pathogenesis and treatment of autoimmune thyroid diseases. Yiqi Jiedu Xiaoying Decoction (YJXD) is a traditional Chinese medicine formula with potential immunomodulatory effects. In this study, we investigated the therapeutic effects of YJXD on EAT in rats and explored its underlying mechanisms. background:
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Organelle Targeted Drug Delivery: Key Challenges, Recent Advancements and Therapeutic Implications Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-02 Dilpreet Singh
: Organelle-specific targeted drug delivery has emerged as a promising approach in the field of drug delivery and therapeutics. This innovative strategy involves the precise delivery of therapeutic agents to specific organelles within cells, such as the nucleus, mitochondria, endoplasmic reticulum, or lysosomes, with the aim of enhancing drug efficacy while minimizing offtarget effects. Despite its
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A Review on the Role of Inflammation in Coronavirus Disease Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-02 Arezoo Lotfi, Pouran Hajian, Laleh Abbasi, Morad Kohandel Gargari, Najmeh Nameh Goshay Fard, Delaram Naderi
: The respiratory illness known as COVID-19 is caused by the novel coronavirus, SARS-CoV-2. While the precise pathogenic mechanism of COVID-19 remains unclear, the occurrence of a cytokine storm subsequent to viral infection plays a pivotal role in the initiation and advancement of the disease. The infection of SARS-CoV-2 induces a state of immune system hyperactivity, leading to an excessive production
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Unraveling the Role of the Glycogen Synthase Kinase-3β, Bruton’s Tyrosine Kinase, and Sphingosine 1 Phosphate Pathways in Multiple Sclerosis Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-02 Rupali Mohite, Sankalp Gharat, Gaurav Doshi
: Inflammation, demyelination, and neurodegeneration are symptoms of the central nervous system (CNS) condition known as Multiple sclerosis (MS). Due to its crucial function in controlling immune cell activation and inflammation, the glycogen synthase kinase-3β (GSK3β), Bruton's tyrosine kinase (BTK), and Sphingosine 1 phosphate (S1P) signaling pathway have become a viable target for the therapy of
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Genetic Polymorphisms of GP1BA, PEAR1, and PAI-1 May Be Associated with Serum sIgE and Blood Eosinophil Levels in Chinese Patients with Allergic Diseases Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-01 Rui Tang, Xiaohong Lyu, Jinlyu Sun, Hong Li
Background: It has been suggested that genetic factors may be substantially linked to allergy disorders. Objective: This study aims to investigate the relationship between the serum specific Immunoglobulin E [sIgE], blood eosinophil, and the polymorphisms of glycoprotein Ib alpha gene [GP1BA] rs6065, platelet endothelial aggregation receptor 1 gene [PEAR1] rs12041331, and plasminogen activator inhibitor
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Mapping the Landscape of Obesity Effects on Male Reproductive Function: A Bibliometric Study Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-01 Yanhong Wei, Meihua Liao, Yiming Lu, Xiaocan Lei, Junli Wang, Linlin Hu, Xiaoqiong Luo
Background:: Due to changes in lifestyle and dietary habits, the global population with obesity is increasing gradually, resulting in a significant rise in the number of individuals having obesity. Obesity is caused by an imbalance between energy intake and consumption, leading to excessive fat accumulation, which interferes with normal human metabolism. It is also associated with cardiovascular disease
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Evaluation of Blood Lactate among Different Player Roles: A Pilot Study on Competitive Young Male Soccer Players Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-01 Rosaria Arcone, Pietro Montesano, Maurizio Di Silvestro, Antonio D'Errico, Rosaria Meccariello, Filomena Mazzeo
Background: Soccer match requires anaerobic and aerobic energetic metabolism. The aim of this pilot study was to investigate the changes in blood lactate concentration in young male soccer players in different playing roles at different time points after the soccer match. Methods: Following an initial screening of 134 young soccer athletes, 8 male athletes (average age of 15.5 ± 5 SD) were chosen for
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Deleterious Biological Effects of Endocrine Disruptors: An Insight into Human Health Risks Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-02-01 Abdullah Al Lawati, Lubna Al Hashmi, Husain Al Aswami, Abdulrahman Al Hadhrami, Kok-Yong Chin, Srijit Das, Srinivasa Rao Sirasanagandla
: Endocrine-disrupting chemicals (EDCs) are environmental pollutants. Since EDCs are present in various consumer products, contamination of human beings is very common. EDCs have deleterious effects on various systems of the body, especially the endocrine and reproductive systems. EDCs interfere with the synthesis, metabolism, binding, or cellular responses of natural estrogens and alter various pathways
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Comparing The Mediterranean and The Japanese Dietary Pattern in Relation to Longevity - A Narrative Review Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-29 Evangelia Damigou, Rena I. Kosti, Shauna M. Downs, Nenad Naumovski, Demosthenes Panagiotakos
Background: The Mediterranean dietary pattern (MDP) and Japanese dietary pattern (JDP) have received increasing attention from the scientific community and media because of their contribution to longevity and health. Although similarities between the two dietary patterns are evident, a detailed comparison between the MDP and the JDP has yet to be explored. Aims: This narrative review aimed to explore
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The Antidiabetic Drug Metformin Attenuated Depressive and Anxietylike Behaviors and Oxidative Stress in the Brain in a Rodent Model of Inflammation Induced by Lipopolysaccharide in Male Rats Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-29 Faezeh Sadat Hosseini Kakhki, Amir Asghari, Zahra Bardaghi, Akbar Anaeigoudari, Farimah Beheshti, Hosseini Salmani, Mahmoud Hosseini
Background: Inflammation is considered to be a link between diabetes and central nervous system (CNS) disorders, including depression and anxiety. Metformin is suggested to have antioxidant, anti-inflammatory, and mood-improving effects. The aim of the current research was to investigate the effects of the antidiabetic drug metformin on depressive- and anxiety- like behaviors and oxidative stress in
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Promising Influences of Moringa oleifera in Functional Foods against Metabolic Syndrome: A Comprehensive and Mechanistic Review Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-26 Mohammad Masoumvand, Elmira Ramezani, Vafa Baradaran Rahimi, Vahid Reza Askari
: Metabolic syndrome (MetS) is now considered a global issue with a growing financial and health impact. Numerous herbal alternatives have been examined and researched due to the ever-increasing demand for new medications to treat metabolic syndrome disorders. People have empirically employed Moringa oleifera (MO), a native plant to several Asian nations, for a variety of diseases. We sought to examine
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In silico Identification of MHC Displayed Tumor Associated Peptides in Ovarian Cancer for Multi-Epitope Vaccine Construct Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-25 Shivashish Dobhal, Kanchan Chauhan, Sachin Kumar, Sristy Shikha, Mukesh Jogi, Dinesh Kumar, Anuj Kumar, Varun Jaiswal, Pramod Kumar
Background: Recognizing the potential of the immune system, immunotherapies have brought about a revolution in the treatment of cancer. Low tumour mutational burden and strong immunosuppression in the peritoneal tumor microenvironment (TME) lead to poor outcomes of immune checkpoint inhibition (ICI) and CART cell therapy in ovarian cancer. Alternative immunotherapeutic strategies are of utmost importance
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Could the Propionic Acid Treatment in Combination with Metformin be Safe for the Small Intestine of Diabetic Rats? Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-24 Larysa Natrus, Olha Lisakovska, Anton Smirnov, Yuliia Osadchuk, Serhyi Savosko, Yuliia Klys
Background:: Effects of propionic acid (PA) on the cellular and molecular processes in the small intestine under type 2 diabetes mellitus (T2DM)-induced endoplasmic reticulum (ER) stress remain incompletely studied. Objectives:: The aim of the study was to assess the state of unfolded protein response (UPR) system in the small intestine of diabetic rats and to explore PA’s influence on metformin treatment
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Insight into the Predictive Power of Surrogate Diagnostic Indices for Identifying Individuals with Metabolic Syndrome Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-23 Shaghayegh Hosseinkhani, Katayoon Forouzanfar, Nastaran Hadizadeh, Farideh Razi, Somayeh Darzi, Fatemeh Bandarian
Background:: This study aimed to assess the diagnostic capability of insulin surrogate measurements in identifying individuals with metabolic syndrome (MetS) and propose applicable indices derived from fasting values, particularly in large study populations. Methods:: Data were collected from the datasets of the Surveillance of Risk Factors of NCDs in Iran Study (STEPS). MetS was defined based on the
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Quetiapine and Valproic Acid-induced Central Hypothyroidism in a Patient with Autism Spectrum Disorder and Intractable Epilepsy: A Case Report Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-22 Narantsatsral Daramjav, Junko Takagi, Hideyuki Iwayama, Kousuke Kanemoto, Kazuo Otake
Objectives: Patients with an autism spectrum disorder (ASD) are prone to disruptive behaviors and aggression. Atypical antipsychotics are used to treat these difficult ASD conditions. Several psychotropic drugs have been linked to hypothyroidism. The clinical manifestation of hypothyroidism is indistinguishable from that of an antipsychotic’s general adverse effect, which can lead to a delayed or missed
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Predicting Factors of Worse Prognosis in COVID-19: Results from a Cross-sectional Study on 52 Inpatients Admitted to the Internal Medicine Department Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-21 Giuseppe Lisco, Antonio Giovanni Solimando, Assunta Stragapede, Anna De Tullio, Cristiana Laraspata, Carola Laudadio, Vito Angelo Giagulli, Marcella Prete, Emilio Jirillo, Annalisa Saracino, Vito Racanelli, Vincenzo Triggiani
Background: The initial phases of the COVID-19 pandemic posed a real need for clinicians to identify patients at risk of poor prognosis as soon as possible after hospital admission. Aim: The study aimed to assess the role of baseline anamnestic information, clinical parameters, instrumental examination, and serum biomarkers in predicting adverse outcomes of COVID-19 in a hospital setting of Internal
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How Different Are the Influences of Mediterranean and Japanese Diets on the Gut Microbiome? Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-21 Dafni Moriki, Despoina Koumpagioti, Maria Pilar Francino, José Ángel Rufián-Henares, Michalis Kalogiannis, Kostas N. Priftis, Konstantinos Douros
: The gut microbiome is a complex ecosystem, mainly composed of bacteria, that performs essential functions for the host. Its composition is determined by many factors; however, diet has emerged as a key regulator. Both the Mediterranean (MD) and Japanese (JD) diets have been associated with significant health benefits and are therefore considered healthy dietary patterns. Both are plant-based diets
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Comprehensive Review on the Genus Haloxylon: Pharmacological and Phytochemical Properties Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-21 Smail Amtaghri, Mohamed Eddouks
Aims: This review aimed to review the biological, pharmacological, and phytochemical aspects of the genus Haloxylon. Background: Plants of the genus Haloxylon have been used for a long time in traditional medicine, and they are distributed in the western Mediterranean region to the Middle East, Iran, Mongolia, Burma, and southwest China. The studied parts of Haloxylon species include aerial parts,
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Transient Central Diabetes Insipidus (Arginine Vasopressin Deficiency) Following SARS-CoV-2 Vaccination: A Case Report and Literature Review Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-21 Pierluigi Mazzeo, Filippo Ceccato, Renzo Manara, Cinzia Mazzon, Mattia Barbot
Introduction: Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people, causing the COVID-19 global pandemic. The use of novel technologies led to the development of different types of SARS-CoV-2 vaccines that have reduced severe disease courses and related deaths. Besides the positive impact of vaccination on the pandemic, local and systemic
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Moroccan Antihypertensive Plants and their Mechanisms of Action Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-21 Smail Amtaghri, Miloudia Slaoui, Mohamed Eddouks
Background: The use of herbal remedies, medicinal plants, and their derivatives for the treatment and control of hypertension is well-known and widespread throughout Morocco. Aims: The aim of the study was to review the antihypertensive and vasorelaxant medicinal plants of the Moroccan pharmacopeia. Objective: To date, no review on Moroccan medicinal plants exhibiting antihypertensive effects has been
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Uniparental Disomy as a Mechanism for Combined Oxidative Phosphorylation Deficiency Associated with MRPS34 Gene Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-21 Marta P. Soares, André M. Travessa, Sónia Custódio, Carla Pereira, Patrícia Pinto, Ana Berta Sousa
Introduction: Mitochondrial oxidative phosphorylation (OXPHOS) is a cellular process that generates most of the cellular energy required by the body. Disorders affecting OXPHOS are multisystem diseases caused by pathogenic variants in more than 50 genes. In 2017, biallelic variants in the MRPS34 gene were shown to cause combined oxidative phosphorylation deficiency type 32 (COPD32) (OMIM#617664); however
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A Comparison of the Decline in Glomerular Filtration Rate between Elderly Patients with Diabetes and those without Diabetes in Southwest China Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-21 Qing-Hua Yi, Hong-Liang Wang, Yun Hou, Lang Xu, Wei-Li Tian, Yi-Xuan Zhang, Yu-Shan Xu, Jia-Bin Shi
Objective: To investigate the effect of high blood glucose on the decline in the estimated glomerular filtration rate (eGFR) in the elderly. Methods: We compared the decline in eGFR of diabetic and non-diabetic groups in the noninterventional state and analyzed the effect of hyperglycemia on the decline in eGFR among the elderly in a retrospective analysis of 1,223 cases of elderly people aged 65 years
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A Correlation Study to Comprehend the SAR-COV-2 Viral Load, Antiviral Antibody Titer, and Severity of COVID-19 Symptoms Post-infection Amongst the Vaccinated Population in Kamrup District of Assam, Northeast India Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-17 Aparup Patra, Asis Bala, Mojibur R. Khan, Ashis K. Mukherjee
Background: As per the recommendation of the United States Food and Drug Administration, more research is needed to determine the antibody titer against COVID-19 vaccination. background: As per the recommendation of the United States Food and Drug Administration, more research is needed to determine the antibody titer against COVID-19 vaccination. Objective: The study aimed to understand the relationship
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The Levels of Phoenixin-14 and Phoenixin-20 in Patients with Type 2 Diabetes Mellitus Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-12 Ummugulsum Can, Sadinaz Akdu, Serdar Şahinoğlu
Background: New pathogenesis-related early detection markers are needed to prevent Type 2 Diabetes Mellitus (T2DM). Objective: We aimed to determine phoenixin (PNX)-14 and PNX-20 levels in T2DM patients and investigate their relationship with diabetes. Methods: 36 T2DM patients and 36 healthy controls were included in the study, and PNX-14 and PNX-20 levels in blood samples taken from the groups were
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Is Kidney Stone Associated with Thyroid Disease? The United States National Health and Nutrition Examination Survey 2007–2018 Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-11 Wenya Xue, Zihan Xue, Yanbing Liu, Pan Yin, Luyu Liu, Shen’ao Qu, Shaobo Wu, Chuance Yang
Background: Kidney stones and thyroid disease are two common diseases in the general population, with multiple common risk factors. The associations between kidney stones and thyroid disease are unclear. background: Kidney stone and thyroid disease are common diseases with multiple common risk factors, but the association between them remains unclear. Aim: This study aims to assess the association
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Differential Gene Expression and Immune Cell Infiltration in Patients with Steroid-induced Necrosis of the Femoral Head Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-11 Guowu Ren, Jie Han, Jian Mo, Zhiwei Xu, Xinjian Feng, Feng Chen, Yukun Wu, Qinglin Peng
Objective:: The study aimed to study the differential gene expression and immune cell infiltration in patients with steroid-induced necrosis of the femoral head (SANFH), identify the key genes and immune cells of SANFH, and explore the relationship between immune cells and SANFH. Methods:: The high-throughput gene chip dataset GSE123568 was downloaded from the GEO database, and the differential gene
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MiR-29b Alleviates High Glucose-induced Inflammation and Apoptosis in Podocytes by Down-regulating PRKAB2 Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-11 Hongxiu Du, Yakun Wang, Yingchun Zhu, Xiaoying Li, Tingying Zhu, Qianqian Wu, Fangfang Zha
Background: Podocyte injury and inflammatory response are the core contributors to the pathogenesis of diabetic nephropathy. This study aims to identify novel regulatory miRNAs and elucidate their underlying mechanisms, which will help us understand the pathogenesis of diabetic nephropathy more comprehensively. background: Podocyte injury and inflammatory response are the core contributors to the pathogenesis
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Investigation of The Effect of Metal-based Medicine Arsenicum album on Humoral Immune Response in SRBC-immunized Mice Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-09 Sangita Behera, Mahima Sharma, Roshan Lal, Raj Kumar Regar, Deepika Tripathi, Pankaj Gupta, G V Narasimha Kumar, Digvijay Verma, Subhash Kaushik, Anil Khurana
Background:: In complementary and alternative medicinal systems, the Arsenicum album in ultra-high dilution was used in various therapeutic conditions, considering its effects on the body’s immune system, including the COVID-19 pandemic. However, scientific evidence regarding its immunomodulatory effects is insufficient. Objective:: The current study aimed to investigate the immunomodulatory effects
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Sufficiency of a Single Negative Thyroglobulin Standard for Judging the Success of Ablation in Low- and Intermediate-risk Differentiated Thyroid Cancer: A Retrospective Study Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-09 Yahong Long, Jianhua Jin, Wanchun Zhang
Background:: We investigated how reduced successful ablation criteria may be used to evaluate radioiodine remnant ablation in patients with low- and intermediate-differentiated thyroid carcinoma (DTC). Methods:: Overall, 254 low- and intermediate-risk patients with DTC were categorized into three groups (positive, weak, positive, and negative) on the basis of a visual study of thyroid imaging performed
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The Application of Artificial Intelligence in Thyroid Nodules: A Systematic Review Based on Bibliometric Analysis Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-05 Yun Peng, Tong-Tong Wang, Jing-Zhi Wang, Heng Wang, Ruo-Yun Fang, Liang-Geng Gong, Wu-Gen Li
Background:: Thyroid nodules are common lesions in benign and malignant thyroid diseases. More and more studies have been conducted on the feasibility of artificial intelligence (AI) in the detection, diagnosis, and evaluation of thyroid nodules. The aim of this study was to use bibliometric methods to analyze and predict the hot spots and frontiers of AI in thyroid nodules. Methods:: Articles on the
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Association between Body Fat Percentage and Cardiometabolic Diseases in General Population Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2024-01-04 Jiayi Si, Lina Kang, Yihai Liu
Objectives:: The body fat percentage is an indicator of overall body fat related to metabolism and inflammation. Our study aims to analyze the association between body fat percentage and the risk of cardiometabolic diseases in the general population. Methods:: This was a retrospectively cross-sectional study. A total of 5084 participants enrolled from the National Health and Nutrition Examination Survey
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Increasing Sanfilippo Syndrome Awareness through Children's Literature and Music Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2023-12-19 Raquel Marques, Rodrigo Carlson, Guilhain Higonnet
: There is an ongoing effort to increase rare disease awareness amongst healthcare providers. This front is important and can help to address several challenges faced by rare disease patients, such as lengthy diagnosis times, difficulty in finding adequate providers of medical services and experts, and adequate treatment if one exists. On another front, there is the need for awareness among citizens
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Pharmacogenetic Variants Can Influence Optical Medication Use Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2023-12-19 Diana Alves, Filipa Ferreira, Cristina Pereira, Altina Lopes, Célia Nogueira, Laura Vilarinho
Introduction:: Single Nucleotide Polymorphisms (SNPs) are used as drug susceptibility biomarkers in metabolic diseases. Alterations in the gene encoding triggers the enzyme flavin monooxygenase 3 (FMO3), involved in the Sulindac metabolization, which also is responsible for the inherited metabolic disorder. Trimethylaminuria (TMAu, OMIM: 602079). DPYD gene variants are associated with the enzyme dihydropyrimidine
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Challenges in Genetic Diagnosis of Mitochondrial Diseases: What Can Functional Genomics' Studies Do? Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2023-12-19 Marta Simões, Maria João Santos, Sara Martins, Maria do Carmo Macário, João Durães, Luísa Diogo, João Paulo Oliveira, José Carlos Ferreira, Manuela Grazina
Introduction:: Mitochondrial oxidative phosphorylation (OXPHOS) diseases are challenging both from clinical and therapeutic perspectives. The advent of next-generation sequencing (NGS) boosted the discovery of new genetic defects affecting OXPHOS, with pathogenic variants identified in >350 genes to date [1]. However, in many patients, novel variants of unknown clinical significance are found. Subsequent
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Pre-implantation Genetic Testing in Inherited Metabolic Diseases? Stateof- the-art and current challenges Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2023-12-19 Ana Miguel Capela, Ana Cunha, Ana Maria Fortuna, Cláudia Falcão Reis
Introduction:: Inborn errors of metabolism (IEM) are genetic diseases involving congenital disorders of enzyme activities. Most follow Mendelian autosomal recessive inheritance and few follow mitochondrial inheritance. In many cases, after the birth of an affected child parents discover that have been the carriers for the condition and worry about the risk of recurrence in future offspring. Preimplantation
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Italian Guidelines for the Management of Sporadic Primary Hyperparathyroidism Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2023-12-15 Fabio Vescini, Giorgio Borretta, Iacopo Chiodini, Marco Boniardi, Marina Carotti, Elena Castellano, Cristiana Cipriani, Cristina Eller-Vainicher, Sandro Giannini, Maurizio Iacobone, Antonio Stefano Salcuni, Federica Saponaro, Stefano Spiezia, Annibale Versari, Guido Zavatta, Zuzana Mitrova, Rosella Saulle, Simona Vecchi, Debora Antonini, Michele Basile, Alexia Giovanazzi, Agostino Paoletta, Enrico
Aim:: This guideline (GL) is aimed at providing a clinical practice reference for the management of sporadic primary hyperparathyroidism (PHPT) in adults. PHPT management in pregnancy was not considered. Methods:: This GL has been developed following the methods described in the Manual of the Italian National Guideline System. For each question, the panel appointed by Associazione Medici Endocrinology
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18 Months of Treatment with Triheptanoin in 2 Patients with Long Chain Fatty Acid Oxidation Disorders Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2023-12-14 Helena Santos, Ana Vieira, Joana Tenente, Ana Carriço, Esmeralda Rodrigues
Introduction:: Long-chain fatty acid oxidation disorders (LC-FAOD) are inborn errors of metabolism, also identified in newborn screening in Portugal. They interfere with adequate energy utilization, namely by muscles, heart, and liver. Treatment aims to maintain patients in an anabolic state, with increased caloric intake, using carbohydrates and medium-chain fatty acids. Treatment with triheptanoin
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Follow-up of Patients with Hereditary Metabolic Diseases during the 3 Years of the Pandemic in the Reference Center for Hereditary Metabolism Diseases of the Centro Hospitalar Universitário Lisboa Norte Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2023-12-14 Anabela Belo, Daniel Gomes, Patricia Nunes, Anabela Oliveira
Introduction:: The adult unit of the Reference Center for Hereditary Metabolism Diseases of the Centro Hospitalar Universitário Lisboa Norte was created in 2002. The team that supports this unit is made up of several specialists, including 2 Internal Medicine Doctors and 2 Nutritionists. The unit carries out its activity mainly in an outpatient clinic on Fridays. Between March 2020 and December 2022
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Muscle Quality and Risk of Metabolic Syndrome in Adult Patients with Inherited Metabolic Diseases Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2023-12-12 Luis Mguel Luengo-Pérez, Ana Ambrojo, Mercedes Fernández-Bueso, Marta Guijarro, Ana Ferreira, Goncalo Luzes, M. Pereira, Conceição Calhau, Júlio Cesar Rocha
: Adult patients with several Inherited Metabolic Diseases (IMD) follow diets controlled in proteins, rich in carbohydrates, and free amino acids formulae, which cause hyperinsulinism and ectopic fat. Previous studies showed IMD adult patients have a higher prevalence of metabolic syndrome and their complications [1]. Recently, ultrasound [US) has been validated for malnutrition, assessing muscle quality
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Eicosapentaenoic Acid as a Cardiovascular Benefit and a Risk of Atrial Fibrillation Endocr. Metab. Immune Disord. Drug Targets (IF 1.9) Pub Date : 2023-12-12 Filippo Egalini, Mattia Rossi, Mauro Massussi, Giulia Gaggero, Guglielmo Beccuti, Andrea Benso, Massimo Francesco Piepoli, Fabio Broglio
: In recent years, scientific research has increasingly focused on the cardiovascular benefits of omega-3 polyunsaturated fatty acids (n-3 PUFAs) supplements. The most promising results emerged from the new trials on high-dose eicosapentaenoic acid (EPA), which is the only approach instead of the previously prescribed therapy with EPA + docosahexaenoic acid (DHA). The evidence of the reduction of cardiovascular