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Effect of viral hepatitis on type 2 diabetes: A Mendelian randomization study. World J. Diabetes (IF 4.2) Pub Date : 2024-3-11 Yun-Feng Yu, Gang Hu, Ke-Ke Tong, Xin-Yu Yang, Jing-Yi Wu, Rong Yu
The effects of viral hepatitis (VH) on type 2 diabetes (T2D) remain controversial.
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Emerging and multifaceted potential contributions of polyphenols in the management of type 2 diabetes mellitus. World J. Diabetes (IF 4.2) Pub Date : 2024-3-11 Ileana González, Cristian Lindner, Ivan Schneider, Erik Diaz, Miguel Angel Morales, Armando Rojas
Type 2 diabetes mellitus (T2DM) is recognized as a serious public health concern with a considerable impact on human life, long-term health expenditures, and substantial health losses. In this context, the use of dietary polyphenols to prevent and manage T2DM is widely documented. These dietary compounds exert their beneficial effects through several actions, including the protection of pancreatic
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Long noncoding RNA protein-disulfide isomerase-associated 3 regulated high glucose-induced podocyte apoptosis in diabetic nephropathy through targeting miR-139-3p. World J. Diabetes (IF 4.2) Pub Date : 2024-3-11 Yin-Xi He, Ting Wang, Wen-Xian Li, Yan-Xia Chen
Podocyte apoptosis plays a vital role in proteinuria pathogenesis in diabetic nephropathy (DN). The regulatory relationship between long noncoding RNAs (lncRNAs) and podocyte apoptosis has recently become another research hot spot in the DN field.
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Genotype-based precision nutrition strategies for the prediction and clinical management of type 2 diabetes mellitus. World J. Diabetes (IF 4.2) Pub Date : 2024-3-11 Omar Ramos-Lopez
Globally, type 2 diabetes mellitus (T2DM) is one of the most common metabolic disorders. T2DM physiopathology is influenced by complex interrelationships between genetic, metabolic and lifestyle factors (including diet), which differ between populations and geographic regions. In fact, excessive consumptions of high fat/high sugar foods generally increase the risk of developing T2DM, whereas habitual
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Balancing act: The dilemma of rapid hyperglycemia correction in diabetes management. World J. Diabetes (IF 4.2) Pub Date : 2024-3-11 Ke-Xin Zhang, Cheng-Xia Kan, Xiao-Dong Sun
The global diabetes surge poses a critical public health challenge, emphasizing the need for effective glycemic control. However, rapid correction of chronic hyperglycemia can unexpectedly trigger microvascular complications, necessitating a reevaluation of the speed and intensity of glycemic correction. Theories suggest swift blood sugar reductions may cause inflammation, oxidative stress, and neurovascular
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Application of non-mydriatic fundus photography-assisted telemedicine in diabetic retinopathy screening. World J. Diabetes (IF 4.2) Pub Date : 2024-3-11 Wan Zhou, Xiao-Jing Yuan, Jie Li, Wei Wang, Hao-Qiang Zhang, Yuan-Yuan Hu, Shan-Dong Ye
Early screening and accurate staging of diabetic retinopathy (DR) can reduce blindness risk in type 2 diabetes patients. DR's complex pathogenesis involves many factors, making ophthalmologist screening alone insufficient for prevention and treatment. Often, endocrinologists are the first to see diabetic patients and thus should screen for retinopathy for early intervention.
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Identification of hub genes associated with Helicobacter pylori infection and type 2 diabetes mellitus: A pilot bioinformatics study. World J. Diabetes (IF 4.2) Pub Date : 2024-3-11 Han Chen, Guo-Xin Zhang, Xiao-Ying Zhou
Helicobacter pylori (H. pylori) infection is related to various extragastric diseases including type 2 diabetes mellitus (T2DM). However, the possible mechanisms connecting H. pylori infection and T2DM remain unknown.
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Vitamin D, selenium, and antidiabetic drugs in the treatment of type 2 diabetes mellitus with Hashimoto's thyroiditis. World J. Diabetes (IF 4.2) Pub Date : 2024-3-11 Fen Feng, Bin Zhou, Ci-La Zhou, Ping Huang, Gang Wang, Kuang Yao
Diabetes and thyroiditis are closely related. They occur in combination and cause significant damage to the body. There is no clear treatment for type-2 diabetes mellitus (T2DM) with Hashimoto's thyroiditis (HT). While single symptomatic drug treatment of the two diseases is less effective, combined drug treatment may improve efficacy.
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Serum tumor markers expression (CA199, CA242, and CEA) and its clinical implications in type 2 diabetes mellitus. World J. Diabetes (IF 4.2) Pub Date : 2024-3-11 Mei Meng, Li-Li Shi
Glucose and lipid metabolic disorder in patients with type 2 diabetes mellitus (T2DM) is associated with the levels of serum tumor markers of the digestive tract, such as cancer antigen (CA)199. Therefore, tumor markers in T2DM are important.
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Age-specific differences in the association between prediabetes and cardiovascular diseases in China: A national cross-sectional study. World J. Diabetes (IF 4.2) Pub Date : 2024-3-11 Shuo Xie, Li-Ping Yu, Fei Chen, Yao Wang, Rui-Fen Deng, Xue-Lian Zhang, Bo Zhang
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, the global burden of which is rising. It is still unclear the extent to which prediabetes contributes to the risk of CVD in various age brackets among adults. To develop a focused screening plan and treatment for Chinese adults with prediabetes, it is crucial to identify variations in the connection between prediabetes
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Diabetes is affecting everyone everywhere. World J. Diabetes (IF 4.2) Pub Date : 2024-3-11 Parul Chawla Gupta, Mona Duggal, Arvind Kumar Morya
The article titled "Accessibility and Utilization of Healthcare Services Among Diabetic Patients: Is Diabetes a Poor Man's Ailment?" gave insights into a pandemic systemic disease known as diabetes mellitus. This modern-era pandemic affects everyone, regardless of their financial background. As a result, diabetes is not a systemic disease which just involves people of low socioeconomic status.
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Elucidating the cardioprotective mechanisms of sodium-glucose cotransporter-2 inhibitors beyond glycemic control. World J. Diabetes (IF 4.2) Pub Date : 2024-3-11 Ke-Xin Zhang, Cheng-Xia Kan, Fang Han, Jing-Wen Zhang, Xiao-Dong Sun
Sodium-glucose cotransporter-2 (SGLT2) inhibitors have emerged as a pivotal intervention in diabetes management, offering significant cardiovascular benefits. Empagliflozin, in particular, has demonstrated cardioprotective effects beyond its glucose-lowering action, reducing heart failure hospitalizations and improving cardiac function. Of note, the cardioprotective mechanisms appear to be inde-pendent
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Analysis of the influencing factors and clinical related characteristics of pulmonary tuberculosis in patients with type 2 diabetes mellitus. World J. Diabetes (IF 4.2) Pub Date : 2024-3-11 Han Shi, Yuan Yuan, Xue Li, Yan-Fang Li, Ling Fan, Xue-Mei Yang
In China, the prevalence of type 2 diabetes mellitus (T2DM) among diabetic patients is estimated to be between 90%-95%. Additionally, China is among the 22 countries burdened by a high number of tuberculosis cases, with approximately 4.5 million individuals affected by active tuberculosis. Notably, T2DM poses a significant risk factor for the development of tuberculosis, as evidenced by the increased
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Glucagon-like peptide-1 receptor agonists as a possible intervention to delay the onset of type 1 diabetes: A new horizon. World J. Diabetes (IF 4.2) Pub Date : 2024-3-11 Mahmoud Nassar, Ajay Chaudhuri, Husam Ghanim, Paresh Dandona
Type 1 diabetes (T1D) is a chronic autoimmune condition that destroys insulin-producing beta cells in the pancreas, leading to insulin deficiency and hyper-glycemia. The management of T1D primarily focuses on exogenous insulin replacement to control blood glucose levels. However, this approach does not address the underlying autoimmune process or prevent the progressive loss of beta cells. Recent research
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Experience of humanistic nursing in hemodialysis nursing for patients with diabetic kidney disease. World J. Diabetes (IF 4.2) Pub Date : 2024-3-11 Xiao-Ying Chai, Xiao-Yan Bao, Ying Dai, Xing-Xing Dai, Yu Zhang, Yu-Ling Yang
Diabetic kidney disease (DKD) is a prevalent complication of diabetes that often requires hemodialysis for treatment. In the field of nursing, there is a growing recognition of the importance of humanistic care, which focuses on the holistic needs of patients, including their emotional, psychological, and social well-being. However, the application of humanistic nursing in the context of hemodialysis
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Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats via glucagon-like peptide 1-mediated Nrf2/HO-1 signaling. World J. Diabetes (IF 4.2) Pub Date : 2024-3-11 Huai-Jie Wang, Li-Bin Zhang, Si-Peng Sun, Qing-Tao Yan, Zhi-Qin Gao, Fang-Ming Fu, Mei-Hua Qu
Type 2 diabetes mellitus (T2DM) is often accompanied by impaired glucose utilization in the brain, leading to oxidative stress, neuronal cell injury and infla-mmation. Previous studies have shown that duodenal jejunal bypass (DJB) surgery significantly improves brain glucose metabolism in T2DM rats, the role and the metabolism of DJB in improving brain oxidative stress and inflammation condition in
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Assessment of pathogenicity and functional characterization of APPL1 gene mutations in diabetic patients. World J. Diabetes (IF 4.2) Pub Date : 2024-3-11 Ping Shi, Yang Tian, Feng Xu, Lu-Na Liu, Wan-Hong Wu, Ying-Zhou Shi, An-Qi Dai, Hang-Yu Fang, Kun-Xia Li, Chao Xu
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1) plays a crucial role in regulating insulin signaling and glucose metabolism. Mutations in the APPL1 gene have been associated with the development of maturity-onset diabetes of the young type 14 (MODY14). Currently, only two mutations [c.1655T>A (p.Leu552*) and c.281G>A p.(Asp94Asn)] have been identified in association
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Management of monogenic diabetes in pregnancy: A narrative review. World J. Diabetes (IF 4.2) Pub Date : 2024-2-5 Mohammad Sadiq Jeeyavudeen, Sarah R Murray, Mark W J Strachan
Pregnancy in women with monogenic diabetes is potentially complex, with significant implications for both maternal and fetal health. Among these, maturity-onset diabetes of the young (MODY) stands out as a prevalent monogenic diabetes subtype frequently encountered in clinical practice. Each subtype of MODY requires a distinct approach tailored to the pregnancy, diverging from management strategies
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Individualized intensive insulin therapy of diabetes: Not only the goal, but also the time. World J. Diabetes (IF 4.2) Pub Date : 2024-2-5 Yun Hu, Hong-Jing Chen, Jian-Hua Ma
Intensive insulin therapy has been extensively used to control blood glucose levels because of its ability to reduce the risk of chronic complications of diabetes. According to current guidelines, intensive glycemic control requires individualized glucose goals rather than as low as possible. During intensive therapy, rapid blood glucose reduction can aggravate microvascular and macrovascular complications
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Urinary exosomal microRNA-145-5p and microRNA-27a-3p act as noninvasive diagnostic biomarkers for diabetic kidney disease. World J. Diabetes (IF 4.2) Pub Date : 2024-2-5 Lu-Lu Han, Sheng-Hai Wang, Ming-Yan Yao, Hong Zhou
Diabetic kidney disease (DKD), characterized by increased urinary microalbumin levels and decreased renal function, is the primary cause of end-stage renal disease. Its pathological mechanisms are complicated and multifactorial; Therefore, sensitive and specific biomarkers are needed. Urinary exosome originate from diverse renal cells in nephron segments and partially mirror the pathological changes
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Nutrition interventions and clinical outcomes of pregnant women with gestational diabetes mellitus: More than meets the eye. World J. Diabetes (IF 4.2) Pub Date : 2024-2-5 Sony Sinha, Prateek Nishant, Ranjeet Kumar Sinha, Arvind Kumar Morya, Ripunjay Prasad
In the retrospective study by Luo et al regarding clinical outcomes in gestational diabetes mellitus (GDM), the results are statistically significant in favour of the benefits of individualized nutrition interventions enumerated therein. The study has provided important evidence to improve maternal and child health in the Asian population. The methods, however, appear to have considerable limi-tations
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Body composition and metabolic syndrome in patients with type 1 diabetes. World J. Diabetes (IF 4.2) Pub Date : 2024-2-5 Qiong Zeng, Xiao-Jing Chen, Yi-Ting He, Ze-Ming Ma, Yi-Xi Wu, Kun Lin
In recent years, the prevalence of obesity and metabolic syndrome in type 1 diabetes (T1DM) patients has gradually increased. Insulin resistance in T1DM deserves attention. It is necessary to clarify the relationship between body composition, metabolic syndrome and insulin resistance in T1DM to guide clinical treatment and intervention.
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Heterogeneously elevated branched-chain/aromatic amino acids among new-onset type-2 diabetes mellitus patients are potentially skewed diabetes predictors. World J. Diabetes (IF 4.2) Pub Date : 2024-2-5 Min Wang, Yang Ou, Xiang-Lian Yuan, Xiu-Fang Zhu, Ben Niu, Zhuang Kang, Bing Zhang, Anwar Ahmed, Guo-Qiang Xing, Heng Su
The lack of specific predictors for type-2 diabetes mellitus (T2DM) severely impacts early intervention/prevention efforts. Elevated branched-chain amino acids (BCAAs: Isoleucine, leucine, valine) and aromatic amino acids (AAAs: Tyrosine, tryptophan, phenylalanine)) show high sensitivity and specificity in predicting diabetes in animals and predict T2DM 10-19 years before T2DM onset in clinical studies
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Myricetin induces M2 macrophage polarization to alleviate renal tubulointerstitial fibrosis in diabetic nephropathy via PI3K/Akt pathway. World J. Diabetes (IF 4.2) Pub Date : 2024-2-5 Wei-Long Xu, Pei-Pei Zhou, Xu Yu, Ting Tian, Jin-Jing Bao, Chang-Rong Ni, Min Zha, Xiao Wu, Jiang-Yi Yu
Development of end-stage renal disease is predominantly attributed to diabetic nephropathy (DN). Previous studies have indicated that myricetin possesses the potential to mitigate the pathological alterations observed in renal tissue. Nevertheless, the precise molecular mechanism through which myricetin influences the progression of DN remains uncertain.
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Effects of Tai Chi in diabetes patients: Insights from recent research. World J. Diabetes (IF 4.2) Pub Date : 2024-2-5 Hidetaka Hamasaki
Tai Chi, a practice that combines elements of both exercise and mindfulness, offers a wide range of health benefits. The body of evidence concerning the impact of Tai Chi on diabetes has recently been growing. This editorial aims to provide a concise summary of the current state of evidence for Tai Chi's effects on individuals with type 2 diabetes (T2D). The review includes 3 randomized controlled
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Clinical study of different prediction models in predicting diabetic nephropathy in patients with type 2 diabetes mellitus. World J. Diabetes (IF 4.2) Pub Date : 2024-2-5 Sha-Sha Cai, Teng-Ye Zheng, Kang-Yao Wang, Hui-Ping Zhu
Among older adults, type 2 diabetes mellitus (T2DM) is widely recognized as one of the most prevalent diseases. Diabetic nephropathy (DN) is a frequent complication of DM, mainly characterized by renal microvascular damage. Early detection, aggressive prevention, and cure of DN are key to improving prognosis. Establishing a diagnostic and predictive model for DN is crucial in auxiliary diagnosis.
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Predictive value of bilirubin and serum γ-glutamyltranspeptidase levels in type-2 diabetes mellitus patients with acute coronary syndrome. World J. Diabetes (IF 4.2) Pub Date : 2024-2-5 Jie Chen, Wan-Chao Zhang, Xiao-Qiang Tang, Ruo-Han Yin, Tao Wang, Xiao-Yu Wei, Chang-Jie Pan
Cardiovascular disease is a major complication of diabetes mellitus (DM). Type-2 DM (T2DM) is associated with an increased risk of cardiovascular events and mortality, while serum biomarkers may facilitate the prediction of these outcomes. Early differential diagnosis of T2DM complicated with acute coronary syndrome (ACS) plays an important role in controlling disease progression and improving safety
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Investigating the relationship between intracranial atherosclerotic plaque remodelling and diabetes using high-resolution vessel wall imaging. World J. Diabetes (IF 4.2) Pub Date : 2024-2-5 Yong-Qian Mo, Hai-Yu Luo, Han-Wen Zhang, Yu-Feng Liu, Kan Deng, Xiao-Lei Liu, Biao Huang, Fan Lin
Intracranial atherosclerosis, a leading cause of stroke, involves arterial plaque formation. This study explores the link between plaque remodelling patterns and diabetes using high-resolution vessel wall imaging (HR-VWI).
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Prediabetes: An overlooked risk factor for major adverse cardiac and cerebrovascular events in atrial fibrillation patients. World J. Diabetes (IF 4.2) Pub Date : 2024-2-5 Rupak Desai, Nishanth Katukuri, Sumaja Reddy Goguri, Azra Kothawala, Naga Ruthvika Alle, Meena Kumari Bellamkonda, Debankur Dey, Sharmila Ganesan, Minakshi Biswas, Kuheli Sarkar, Pramoda Prattipati, Shaylika Chauhan
Prediabetes is a well-established risk factor for major adverse cardiac and cerebrovascular events (MACCE). However, the relationship between prediabetes and MACCE in atrial fibrillation (AF) patients has not been extensively studied. Therefore, this study aimed to establish a link between prediabetes and MACCE in AF patients.
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Relationship between GCKR gene rs780094 polymorphism and type 2 diabetes with albuminuria. World J. Diabetes (IF 4.2) Pub Date : 2024-1-15 Yi-Ying Liu, Qin Wan
Diabetic kidney disease is one of the common complications of type 2 diabetes (T2D). There are no typical symptoms in the early stage, and the disease will progress to moderate and late stage when albuminuria reaches a high level. Treatment is difficult and the prognosis is poor. At present, the pathogenesis of diabetic kidney disease is still unclear, and it is believed that it is associated with
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Comparative analysis of Nε-carboxymethyl-lysine and inflammatory markers in diabetic and non-diabetic coronary artery disease patients. World J. Diabetes (IF 4.2) Pub Date : 2024-1-15 Dharmsheel Shrivastav, Desh Deepak Singh, Rashid Mir, Pratishtha Mehra, Vimal Mehta, Pradeep Kumar Dabla
Coronary artery disease (CAD) is a major cause of death worldwide, and India contributes to about one-fifth of total CAD deaths. The development of CAD has been linked to the accumulation of Nε-carboxymethyl-lysine (CML) in heart muscle, which correlates with fibrosis.
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Early hemodynamics after tibial transverse transport in patients with nonarterial stenosis and arterial stenosis diabetic foot. World J. Diabetes (IF 4.2) Pub Date : 2024-1-15 Mei-Mei Liao, Sen Chen, Jia-Rui Cao, Meng-Wei Wang, Zhi-Hui Jin, Jia Ye, Yi-Jun Ren, Rui-Qiang Guo
The diagnosis of peripheral arteriopathy in the diabetic foot is complicated by diabetes and its advanced complications. It has been found that diabetic foot can be categorized into arterial stenosis and non-arterial stenosis, both of which have significant differences in hemodynamic characteristics.
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Atorvastatin ameliorated myocardial fibrosis in db/db mice by inhibiting oxidative stress and modulating macrophage polarization. World J. Diabetes (IF 4.2) Pub Date : 2024-1-15 Xian-Min Song, Meng-Nan Zhao, Gui-Zhi Li, Na Li, Ting Wang, Hong Zhou
People with diabetes mellitus (DM) suffer from multiple chronic complications due to sustained hyperglycemia, especially diabetic cardiomyopathy (DCM). Oxidative stress and inflammatory cells play crucial roles in the occurrence and progression of myocardial remodeling. Macrophages polarize to two distinct phenotypes: M1 and M2, and such plasticity in phenotypes provide macrophages various biological
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Depletion of gut microbiota facilitates fibroblast growth factor 21-mediated protection against acute pancreatitis in diabetic mice. World J. Diabetes (IF 4.2) Pub Date : 2024-1-15 Qi-Yan Sun, Xu-Ye Wang, Zu-Pin Huang, Jing Song, En-Dong Zheng, Fang-Hua Gong, Xiao-Wang Huang
Fibroblast growth factor 21 (FGF21), primarily secreted by the pancreas, liver, and adipose tissues, plays a pivotal role in regulating glucose and lipid metabolism. Acute pancreatitis (AP) is a common inflammatory disease with specific clinical manifestations. Many patients with diabetes present with concurrent inflammatory symptoms. Diabetes exacerbates intestinal permeability and intestinal inflammation
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Potential therapeutic targets for the prevention of diabetic nephropathy: Glycyrrhetinic acid. World J. Diabetes (IF 4.2) Pub Date : 2024-1-15 Lu Cai, Michael Horowitz, Md Shahidul Islam
Uncontrolled hyperglycemia or poorly managed disease increases the propensity for a number of diabetes-related complications targeting major organs including the heart, eyes, and kidney. Although the mechanisms by which diabetes induces cardiovascular diseases include oxidative stress and inflammation, when insulin resistance remains the key to the pathogenesis, as implicated in the two reviews in
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Analysis of the management and therapeutic performance of diabetes mellitus employing special target. World J. Diabetes (IF 4.2) Pub Date : 2024-1-15 Hong-Yan Sun, Xiao-Yan Lin
Diabetes mellitus (DM) is a chronic metabolic condition characterized predominantly by hyperglycemia. The most common causes contributing to the pathophysiology of diabetes are insufficient insulin secretion, resistance to insulin's tissue-acting effects, or a combination of both. Over the last 30 years, the global prevalence of diabetes increased from 4% to 6.4%. If no better treatment or cure is
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Acupuncture in diabetic peripheral neuropathy-neurological outcomes of the randomized acupuncture in diabetic peripheral neuropathy trial. World J. Diabetes (IF 4.2) Pub Date : 2024-1-15 Sebastian Hoerder, Isabel Valentina Habermann, Katrin Hahn, Gesa Meyer-Hamme, Miriam Ortiz, Weronika Grabowska, Stephanie Roll, Stefan N Willich, Sven Schroeder, Benno Brinkhaus, Joanna Dietzel
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus and can lead to serious complications. Therapeutic strategies for pain control are available but there are few approaches that influence neurological deficits such as numbness.
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Establishment of models to predict factors influencing periodontitis in patients with type 2 diabetes mellitus. World J. Diabetes (IF 4.2) Pub Date : 2024-1-15 Hong-Miao Xu, Xuan-Jiang Shen, Jia Liu
Type 2 diabetes mellitus (T2DM) is associated with periodontitis. Currently, there are few studies proposing predictive models for periodontitis in patients with T2DM.
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Empagliflozin ameliorates diabetic cardiomyopathy probably via activating AMPK/PGC-1α and inhibiting the RhoA/ROCK pathway. World J. Diabetes (IF 4.2) Pub Date : 2024-1-15 Na Li, Qiu-Xiao Zhu, Gui-Zhi Li, Ting Wang, Hong Zhou
Diabetic cardiomyopathy (DCM) increases the risk of hospitalization for heart failure (HF) and mortality in patients with diabetes mellitus. However, no specific therapy to delay the progression of DCM has been identified. Mitochondrial dysfunction, oxidative stress, inflammation, and calcium handling imbalance play a crucial role in the pathological processes of DCM, ultimately leading to cardiomyocyte
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Maturity-onset diabetes of the young type 10 caused by an Ala2Thr mutation of INS: A case report. World J. Diabetes (IF 4.2) Pub Date : 2024-1-15 Huan Chen, Si-Jia Fei, Ming-Qun Deng, Xin-Da Chen, Wei-Hao Wang, Li-Xin Guo, Qi Pan
Maturity-onset diabetes of the young 10 caused by the c.4G>A (p.Ala2Thr) mutation is extremely rare, with only two reported studies to date. Herein, we report another case that differs from previous cases in phenotype.
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Comparative study of type 2 diabetes mellitus-associated gut microbiota between the Dai and Han populations. World J. Diabetes (IF 4.2) Pub Date : 2024-1-15 Ling-Tong Tang, Lei Feng, Hui-Ying Cao, Rui Shi, Bei-Bei Luo, Yan-Bi Zhang, Yan-Mei Liu, Jian Zhang, Shuang-Yue Li
The global prevalence of type 2 diabetes mellitus (T2DM) is increasing. T2DM is associated with alterations of the gut microbiota, which can be affected by age, illness, and genetics. Previous studies revealed that there are discriminating microbiota compositions between the Dai and the Han populations. However, the specific gut microbiota differences between the two populations have not been elucidated
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Diabetes mellitus and prostate cancer risk: A mendelian randomization analysis. World J. Diabetes (IF 4.2) Pub Date : 2024-1-15 Jian-Xu Yuan, Qing Jiang, Sheng-Jie Yu
Some studies have directed towards an association between diabetes mellitus (DM) and prostate cancer (PCa); however, this specific relationship remains inconclusive. In recent years, Mendelian randomization (MR) has become a widely used analytical method for inferring epidemiological causes.
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Genetic perspectives on childhood monogenic diabetes: Diagnosis, management, and future directions. World J. Diabetes (IF 4.2) Pub Date : 2024-1-15 Hong-Yan Sun, Xiao-Yan Lin
Monogenic diabetes is caused by one or even more genetic variations, which may be uncommon yet have a significant influence and cause diabetes at an early age. Monogenic diabetes affects 1 to 5% of children, and early detection and gene-tically focused treatment of neonatal diabetes and maturity-onset diabetes of the young can significantly improve long-term health and well-being. The etiology of monogenic
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Indirect comparison of efficacy and safety of chiglitazar and thiazolidinedione in patients with type 2 diabetes: A meta-analysis. World J. Diabetes (IF 4.2) Pub Date : 2023-10-15 Chu Lin,Zong-Lin Li,Xiao-Ling Cai,Sui-Yuan Hu,Fang Lv,Wen-Jia Yang,Li-Nong Ji
BACKGROUND Chiglitazar is an emerging pan-agonist of all peroxisome proliferator activated receptors (PPAR)-α, δ and γ, and has therapeutic potential for type 2 diabetes (T2D). However, to date, no clinical studies or meta-analyses have compared the efficacy and safety of chiglitazar and traditional PPAR-γ agonist thiazolidinediones (TZDs). A meta-analysis concerning this topic is therefore required
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Characteristics of glucose change in diabetes mellitus generalized through continuous wavelet transform processing: A preliminary study. World J. Diabetes (IF 4.2) Pub Date : 2023-10-15 Yoichi Nakamura,Shinya Furukawa
BACKGROUND The continuous glucose monitoring (CGM) system has become a popular evaluation tool for glucose fluctuation, providing a detailed description of glucose change patterns. We hypothesized that glucose fluctuations may contain specific information on differences in glucose change between type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), despite similarities in change patterns
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Partners in diabetes epidemic: A global perspective. World J. Diabetes (IF 4.2) Pub Date : 2023-10-15 Huan Wang,Safoura Akbari-Alavijeh,Ranjit S Parhar,Randy Gaugler,Sarwar Hashmi
There is a recent increase in the worldwide prevalence of both obesity and diabetes. In this review we assessed insulin signaling, genetics, environment, lipid metabolism dysfunction and mitochondria as the major determinants in diabetes and to identify the potential mechanism of gut microbiota in diabetes diseases. We searched relevant articles, which have key information from laboratory experiments
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Multifaceted relationship between diabetes and kidney diseases: Beyond diabetes. World J. Diabetes (IF 4.2) Pub Date : 2023-10-15 Pasquale Esposito,Daniela Picciotto,Francesca Cappadona,Francesca Costigliolo,Elisa Russo,Lucia Macciò,Francesca Viazzi
Diabetes mellitus is one of the most common causes of chronic kidney disease. Kidney involvement in patients with diabetes has a wide spectrum of clinical presentations ranging from asymptomatic to overt proteinuria and kidney failure. The development of kidney disease in diabetes is associated with structural changes in multiple kidney compartments, such as the vascular system and glomeruli. Glomerular
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Analysis of influencing factors and interaction of body weight and disease outcome in patients with prediabetes. World J. Diabetes (IF 4.2) Pub Date : 2023-10-15 Yan-Yan Li,Lin-Ping Tong,Xian-Dan Wu,Dan Lin,Yue Lin,Xiao-Yang Lin
BACKGROUND The trend of prediabetes progressing to type 2 diabetes mellitus (T2DM) is prominent, and effective intervention can lead to a return to prediabetes. Exploring the factors influencing the outcome of prediabetes is helpful to guide clinical intervention. The weight change in patients with prediabetes has not attracted much attention. AIM To explore the interaction between body weight and
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Role of glycolysis in diabetic atherosclerosis. World J. Diabetes (IF 4.2) Pub Date : 2023-10-15 Qian-Jia Liu,Wei Yuan,Ping Yang,Chen Shao
Diabetes mellitus is a kind of typical metabolic disorder characterized by elevated blood sugar levels. Atherosclerosis (AS) is one of the most common complications of diabetes. Modern lifestyles and trends that promote overconsumption and unhealthy practices have contributed to an increase in the annual incidence of diabetic AS worldwide, which has created a heavy burden on society. Several studies
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Gut microbiome supplementation as therapy for metabolic syndrome. World J. Diabetes (IF 4.2) Pub Date : 2023-10-15 Mc Anto Antony,Aniqa Chowdhury,Dinesh Edem,Rishi Raj,Priyanshu Nain,Mansi Joglekar,Vipin Verma,Ravi Kant
The gut microbiome is defined as an ecological community of commensal symbiotic and pathogenic microorganisms that exist in our body. Gut microbiome dysbiosis is a condition of dysregulated and disrupted intestinal bacterial homeostasis, and recent evidence has shown that dysbiosis is related to chronic inflammation, insulin resistance, cardiovascular diseases (CVD), type 2 diabetes mellitus (T2DM)
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Establishment and evaluation of a risk prediction model for gestational diabetes mellitus. World J. Diabetes (IF 4.2) Pub Date : 2023-10-15 Qing Lin,Zhuan-Ji Fang
BACKGROUND Gestational diabetes mellitus (GDM) is a condition characterized by high blood sugar levels during pregnancy. The prevalence of GDM is on the rise globally, and this trend is particularly evident in China, which has emerged as a significant issue impacting the well-being of expectant mothers and their fetuses. Identifying and addressing GDM in a timely manner is crucial for maintaining the
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Effects of insulin aspart and metformin on gestational diabetes mellitus and inflammatory markers. World J. Diabetes (IF 4.2) Pub Date : 2023-10-15 Yan Wang,Min Song,Bang-Ruo Qi
BACKGROUND Gestational diabetes mellitus (GDM) refers to hyperglycemia caused by insulin resistance or insufficient insulin secretion during pregnancy. Patients with GDM have a high risk of pregnancy complications, which can adversely affect both maternal and fetal health. Therefore, early diagnosis, treatment and monitoring of GDM are essential. In recent years, a new treatment scheme represented
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Effect of individualized nutrition interventions on clinical outcomes of pregnant women with gestational diabetes mellitus. World J. Diabetes (IF 4.2) Pub Date : 2023-10-15 Jian-Ying Luo,Lang-Gui Chen,Mei Yan,Yue-Jing Mei,Ya-Qian Cui,Min Jiang
BACKGROUND Gestational diabetes mellitus (GDM) can lead to excessive pregnancy weight gain (PWG), abnormal glucolipid metabolism, and delayed lactation. Therefore, it is necessary to provide appropriate and effective interventions for pregnant women with GDM. AIM To clarify the effects of individualized nutrition interventions on PWG, glucolipid metabolism, and lactation in pregnant women with GDM
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Effects of vitamin D supplementation on glucose and lipid metabolism in patients with type 2 diabetes mellitus and risk factors for insulin resistance. World J. Diabetes (IF 4.2) Pub Date : 2023-10-15 Li-Jie Sun,Ji-Xuan Lu,Xin-Yu Li,Tian-Sheng Zheng,Xiao-Rong Zhan
BACKGROUND Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease featured by insulin resistance (IR) and decreased insulin secretion. Currently, vitamin D deficiency is found in most patients with T2DM, but the relationship between vitamin D and IR in T2DM patients requires further investigation. AIM To explore the risk factors of IR and the effects of vitamin D supplementation on glucose
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Accessibility and utilization of healthcare services among diabetic patients: Is diabetes a poor man's ailment? World J. Diabetes (IF 4.2) Pub Date : 2023-10-15 Chiedu Eseadi,Amos Nnaemeka Amedu,Leonard Chidi Ilechukwu,Millicent O Ngwu,Osita Victor Ossai
Diabetes is a non-communicable ailment that has adverse effects on the individual's overall well-being and productivity in society. The main objective of this study was to examine the empirical literature concerning the association between diabetes and poverty and the accessibility and utilization of medical care services among diabetic patients. The diabetes literature was explored using a literature
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Effects of paricalcitol combined with hemodiafiltration on bone-metabolism-related indexes in patients with diabetic nephropathy and chronic renal failure. World J. Diabetes (IF 4.2) Pub Date : 2023-9-29 Xiao-Ying Ma, Yu-Ping Sheng, Xing-Meng Yang, Hao-Ran Zhang, Fu-Yun Sun
Diabetic nephropathy (DN) is frequently seen in the development of diabetes mellitus, and its pathogenic factors are complicated. Its current treatment is controversial, and there is a lack of a relevant efficacy prediction model.
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Risk factors of concurrent urinary sepsis in patients with diabetes mellitus comorbid with upper urinary tract calculi. World J. Diabetes (IF 4.2) Pub Date : 2023-9-29 Jian-Jie Gou, Chao Zhang, Hai-Song Han, Hong-Wei Wu
Urinary sepsis is frequently seen in patients with diabetes mellitus (DM) complicated with upper urinary tract calculi (UUTCs). Currently, the known risk factors of urinary sepsis are not uniform.
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Early neonatal complications in pregnant women with gestational diabetes mellitus and the effects of glycemic control on neonatal infection. World J. Diabetes (IF 4.2) Pub Date : 2023-9-29 Bei-Bei Wang, Mei Xue
Gestational diabetes mellitus (GDM) has become increasingly prevalent globally. Glycemic control in pregnant women with GDM has a critical role in neonatal complications.
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Effectiveness and safety of traditional Chinese medicine for diabetic retinopathy: A systematic review and network meta-analysis of randomized clinical trials. World J. Diabetes (IF 4.2) Pub Date : 2023-9-29 Hong-Dian Li, Ming-Xuan Li, Wen-Hua Zhang, Shu-Wen Zhang, Yan-Bing Gong
Diabetic retinopathy (DR) is currently recognized as one of the most serious diabetic microangiopathies and a major cause of adult blindness. Commonly used clinical approaches include etiological control, microvascular improvement, and surgical intervention, but they are ineffective and have many side effects. Oral Chinese medicine (OCM) has been used for thousands of years to treat DR and is still
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MicroRNA-155 mediates endogenous angiotensin II type 1 receptor regulation: implications for innovative type 2 diabetes mellitus management. World J. Diabetes (IF 4.2) Pub Date : 2023-9-29 Konstantinos I Papadopoulos, Alexandra Papadopoulou, Tar-Choon Aw
Type 2 diabetes mellitus (T2DM) is a lifelong condition and a threat to human health. Thorough understanding of its pathogenesis is acutely needed in order to devise innovative, preventative, and potentially curative pharmacological interventions. MicroRNAs (miRNA), are small, non-coding, one-stranded RNA molecules, that can target and silence around 60% of all human genes through translational repression