-
Head-to-head comparison of American, European, and Asian TIRADSs in thyroid nodule assessment: systematic review and meta-analysis Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-04-01 Tommaso Piticchio, Gilles Russ, Maija Radzina, Francesco Frasca, Cosimo Durante, Pierpaolo Trimboli
Context Ultrasound-based risk stratification systems (Thyroid Imaging Reporting and Data Systems (TIRADSs)) of thyroid nodules (TNs) have been implemented in clinical practice worldwide based on their high performance. However, it remains unexplored whether different TIRADSs perform uniformly across a range of TNs in routine practice. This issue is highly relevant today, given the ongoing international
-
Serum anti-Müllerian hormone is lower in patients with multiple radioiodine dose for treatment of pediatric thyroid cancer Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-04-01 Marise Codeco de Andrade Barreto, Natalia Treistman, Lara Bessa Campelo Pinheiro Cavalcante, Daniel Bulzico, Fernanda Accioly de Andrade, Rossana Corbo, Paulo Alonso Garcia Alves Junior, Fernanda Vaisman
Introduction Treatment of patients with pediatric differentiated thyroid cancer (DTC) often involves radioiodine (RAI), which is associated with increased risks of short- and long-term adverse outcomes. The impact of RAI treatment on the female reproductive system remains uncertain. Anti-Müllerian hormone (AMH) is a marker of ovarian reserve and is related to fertility. Objective The aim was to analyze
-
Hypothyroxinaemia during gestation is associated with low ferritin and increased levels of inflammatory markers Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-04-01 Victor J M Pop, Johannes G Krabbe, Maarten Broeren, Wilmar Wiersinga, Margaret P Rayman
Objective Pregnancy is a state of physiological inflammation facilitating implantation. Early isolated hypothyroxinaemia (IH) and increased inflammation (including obesity) have been associated with severe obstetric complications. The current study evaluated the association between IH, low ferritin and inflammation parameters (interleukin 6 (IL-6), C-reactive protein (CRP), human chorionic gonadotrophin
-
Feasibility of Active Surveillance in Patients with Clinically T1b Papillary Thyroid Carcinoma ≤1.5 cm in Preoperative Ultrasonography: MASTER Study Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-03-01 Sang-Hyeon Ju, Yong Bae Ji, Minchul Song, Joung Youl Lim, Da Beom Heo, Min-Gyu Kim, Jae Won Chang, Ho-Ryun Won, Yea Eun Kang, Eu Jeong Ku, Mijin Kim, Eun Kyung Lee, June Young Choi, Hyeong Won Yu, Young Joo Park, Jun-Ho Choe, Bon Seok Koo
Objective: Active surveillance (AS) is generally accepted as an alternative to immediate surgery for papillary thyroid carcinoma (PTC) measuring ≤1.0 cm (cT1a) without risk factors. This study investigated the clinicopathologic characteristics of PTCs measuring ≤2.0 cm without cervical lymph node metastasis (cT1N0) by tumor size group to assess the feasibility of AS for PTCs between 1.0 cm and 1.5
-
Alemtuzumab-induced thyroid eye disease successfully treated with a single low-dose of rituximab Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-03-01 Ilaria Muller, Sara Maioli, Mirco Armenti, Laura Porcaro, Nicola Currò, Elisabetta Iofrida, Lorenzo Pignataro, Jacopo Manso, Caterina Mian, Jens Geginat, Mario Salvi
BACKGROUND Secondary thyroid autoimmunity, especially Graves’ disease (GD), frequently develops in patients with multiple sclerosis (MS) following alemtuzumab treatment (ALTZ; anti-CD52). Thyroid Eye Disease (TED) can also develop, and rituximab (RTX; anti-CD20) is a suitable treatment. METHODS Immunophenotyping of blood and thyroid-derived lymphocytes in a patient treated with both ALTZ and RTX. RESULTS
-
Climate Changes Affecting Global Iodine Status Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-03-01 Peter Smyth, Colin D O'Dowd
Global warming is now universally acknowledged as being responsible for dramatic climate changes with rising sea levels, unprecedented temperatures, resulting fires and threatened widespread species loss. While these effects are extremely damaging, threatening the future of life on our planet, one unexpected and paradoxically beneficial consequence could be a significant contribution to global iodine
-
Selenium supplementation and placebo are equally effective in improving quality of life in patients with hypothyroidism Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Camilla Bøgelund Larsen, Kristian Hillert Winther, Per Karkov Cramon, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen, Nils Jakob Knudsen, Jakob Bue Bjorner, Lutz Schomburg, Kamil Demircan, Thilo Samson Chillon, Jeppe Gram, Stinus Gadegaard Hansen, Frans Brandt, Birte Nygaard, Torquil Watt, Laszlo Hegedüs, Steen Joop Bonnema
Purpose We investigated whether selenium supplementation improves quality-of-life (QoL) in patients with autoimmune thyroiditis (ID:NCT02013479). Methods We included 412 patients ≥18 years with serum thyroid peroxidase antibody (TPOAb) level ≥100 IU/mL in a multicentre double-blinded randomised clinical trial. The patients were allocated 1:1 to daily supplementation with either 200 μg selenium as selenium-enriched
-
Psychiatric complications in Graves’ disease Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Mats Holmberg, Helge Malmgren, Peter F Berglund, Birgitta Johansson, Helena Filipsson Nyström
Background Mood disorders are common in Graves’ disease despite treatment. The pathogenic mechanisms involved are unknown and so is whether previous psychiatric disease influences these symptoms. Methods This is a longitudinal study conducted in Sweden on 65 women with newly diagnosed Graves’ disease and 65 matched controls. Participants were examined during hyperthyroidism and after 15 months of treatment
-
Insights on the role of thyroid hormone transport in neurosensory organs and implication for Allan-Herndon-Dudley syndrome Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Ángel García-Aldea, Marina Guillén-Yunta, Víctor Valcárcel-Hernández, Ana Montero-Pedrazuela, Ana Guadaño-Ferraz, Soledad Bárez-López
Thyroid hormones play an important role during the development and functioning of the different sensory systems. In order to exert their actions, thyroid hormones need to access their target cells through transmembrane transporter proteins, among which the monocarboxylate transporter 8 (MCT8) stands out for its pathophysiological relevance. Mutations in the gene encoding for MCT8 lead to the Allan-Herndon-Dudley
-
Relationship between maternal obesity and first trimester TSH in women with negative anti-TPO antibodies Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Laura Croce, Fausta Beneventi, Federica Ripepi, Irene De Maggio, Alberto Malovini, Camilla Bellingeri, Francesca Coperchini, Marsida Teliti, Mario Rotondi, Arsenio Spinillo, Flavia Magri
Objective: obesity is associated with increased Thyroid-stimulating-hormone (TSH) in non-pregnant subjects, but this phenomenon has not been fully characterized during pregnancy. Our aim was to evaluate the impact of Body-Mass-Index (BMI) on first-trimester TSH in a wide cohort of pregnant women with negative anti-Thyreoperoxidase-Antibodies (AbTPO) and its implications on uterine-artery pulsatility-index
-
Epidemiology, prognosis and challenges in the management of Hyperthyroidism-related Atrial Fibrillation Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Georgios Kostopoulos, Grigoris Effraimidis
Atrial fibrillation (AF) is a common condition with a global estimated prevalence of 60 million cases, and the most common cardiac complication of hyperthyroidism, occurring in 5-15% of overtly hyperthyroid patients. Additionally, subclinical hyperthyroidism and high-normal free T4 have been associated with an increased risk in the development of AF. Hyperthyroidism-related AF is a reversible cause
-
The intermediary between the brain and the immune system is likely to be the thyroid Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Leonidas Duntas
NA
-
Hyperthyroidism and the Risk of Non-Thyroid Cancer: A Danish Register-Based Long-Term Follow-Up Study Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Thea Riis, Steen Joop Bonnema, Thomas Heiberg Brix, Lars Folkestad
Objectives: Cancer is the second most common cause of death worldwide. It is currently debated whether thyroid dysfunction is a modifiable cancer risk factor. Our aim was to evaluate the risk of cancer in patients with hyperthyroidism. Methods: This is a register-based nationwide cohort study of individuals with a diagnosis of hyperthyroidism. Each hyperthyroid case was matched with four reference
-
The ETA–ESE statement on the European Chemicals Agency opinion on iodine as an endocrine disruptor Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Rodrigo Moreno-Reyes, Ulla Feldt-Rasmussen, Agnieszka Piekiełko-Witkowska, Adriana Gaspar da Rocha, Corin Badiu, Josef Köhrle, Leonidas Duntas
Graphical abstract Abstract In 2022, the European Chemicals Agency (ECHA) made a statement concluding that iodine is an endocrine disruptor (ED). We stress the fact that the ECHA opinion ECHA/BPC/357/2022 is based on their misguidedly zooming in on exclusively the biocidal products (e.g. hand disinfectants, disinfection of animals’ teats/udder, embalming fluids before cremation) that contain molecular
-
Two-year prognosis of multinodular goiter following radiofrequency ablation based on all nodule burdens Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Rui Guo, Bowen Zheng, Tao Wu, Yufan Lian, Tinghui Yin, Yuting He, Jingya Qin, Zhicheng Yao, Wen Xu, Jie Ren
Objective Few studies use all nodule burdens to specify the prognosis of multinodular goiter (MNG) following radiofrequency ablation (RFA), so this study addresses this question for MNG after completely ablating dominant nodules. Methods The RFA indications for MNG include 2–5 benign nodules with over 50% normal tissue on ultrasound, 1–3 well-defined benign dominant nodules on cytology, largest diameter
-
The hypothalamic–pituitary–thyroid axis is intact in male Irs4 knockout mice Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Emilie Brûlé, Xiang Zhou, Ying Wang, Evan R S Buddle, Luisina Ongaro, Mary Loka, Anita Boelen, Daniel J Bernard
Objective Loss of function mutations in the insulin receptor substrate 4 (IRS4) gene cause a rare form of X-linked congenital central hypothyroidism in boys and men. Affected individuals show decreased thyroid-stimulating hormone (TSH) secretion. Members of the IRS family canonically act as scaffold proteins between tyrosine kinase receptors and downstream effectors. How loss of IRS4 affects TSH synthesis
-
Review of the PRIODAC project on thyroid protection from radioactive iodine by repeated iodide intake in individuals aged 12+ Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Jean-Charles Martin, Thierry Pourcher, Guillaume Phan, Julien Guglielmi, Caroline Crambes, François Caire-Maurisier, Dalila Lebsir, David Cohen, Clément Rosique, Lun Jing, Maha Hichri, Lisa Salleron, Jacques Darcourt, Maamar Souidi, Marc Benderitter
Background Intake of potassium iodide (KI) reduces the accumulation of radioactive iodine in the thyroid gland in the event of possible contamination by radioactive iodine released from a nuclear facility. The World Health Organization (WHO) has stated the need for research for optimal timing, appropriate dosing regimen, and safety for repetitive iodine thyroid blocking (ITB). The French PRIODAC project
-
Next-generation sequencing on fine needle aspirates in neck recurrence of thyroid cancers Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Hélène Théodon, Erell Guillerm, Johanna Wassermann, Gabrielle Deniziaut, Loïc Jaffrelot, Jérome Denis, Nathalie Chereau, Claude Bigorgne, Wiame Potonnier, Florence Coulet, Laurence Leenhardt, Camille Buffet
Objective Tumor molecular genotyping plays a key role in improving the management of advanced thyroid cancers. Molecular tests are classically performed on formalin-fixed, paraffin-embedded (FFPE) carcinoma tissue. However alternative molecular testing strategies are needed when FFPE tumoral tissue is unavailable. The objective of our study was to retrospectively assess the performance of targeted
-
Predicting glucocorticoid effectiveness in thyroid eye disease: combined value from serological lipid metabolism and an orbital MRI parameter Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Haitao Zhang, Hao Hu, Yueyue Wang, Xinjie Duan, Lu Chen, Jiang Zhou, Wen Chen, Weizhong Zhang, Xiaoquan Xu, Huanhuan Chen
Purpose The aim was to determine the combined value of serological lipid metabolism and an orbital MRI quantitative parameter in predicting the effectiveness of glucocorticoid (GC) therapy in patients with thyroid eye disease (TED). Methods This study retrospectively enrolled 46 patients with active and moderate-to-severe TED (GC-effective group, n = 29; GC-ineffective group, n = 17). Serological lipid
-
Diagnostic utility of repeat fine needle aspirations of benign thyroid nodules Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Rachelle P Mendoza, Richard Cody Simon, Nicole A Cipriani, Tatjana Antic
Objective This study aims to analyze the diagnostic utility of multiple repeat FNA on thyroid nodules with initially benign diagnosis. Methods In a 5-year period, 1658 thyroid nodules with initially benign FNAs were retrospectively reviewed and followed for subsequent resection and repeat biopsy. Results Out of 2150 thyroid nodules, 1658 (77.1%) were diagnosed as benign on FNAs. The average age at
-
Real-world clinical profile, RET mutation testing, treatments and patient-related outcomes for medullary thyroid cancer in Europe Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Grace Segall, Ravinder Singh, Min-Hua Jen, Isaac Sanderson, Alex Rider, Katie Lewis, Urpo Kiiskinen
Objective This study aimed to describe real-world patient and physician characteristics, rearranged during transfection (RET) mutation testing and results, treatment patterns and patient-reported outcomes (PROs) in advanced or metastatic medullary thyroid cancer (aMTC) across five populous European countries. Methods Cross-sectional physician and patient surveys were used to collect quantitative and
-
Combinatorial hypofractionated radiotherapy and pembrolizumab in anaplastic thyroid cancer Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Janice Ser Huey Tan, Timothy Kwang Yong Tay, Enya Hui Wen Ong, Michael Fehlings, Daniel Shao-Weng Tan, Nadiah Binte Sukma, Eileen Xueqin Chen, Jen-Hwei Sng, Connie Siew Poh Yip, Kok Hing Lim, Darren Wan-Teck Lim, Narayanan Gopalakrishna Iyer, Jacqueline Siok Gek Hwang, Melvin Lee Kiang Chua, Mei-Kim Ang
Objective Anaplastic thyroid cancer (ATC) is an aggressive disease associated with poor outcomes and resistance to therapies. Our study aim was to evaluate the activity of a combinatorial regimen of sandwich sequencing of pembrolizumab immunotherapy and hypofractionated radiotherapy (RT). Methods In this case series, patients with ATC received hypofractionated RT (QUAD-shot) and intravenous pembrolizumab
-
The diagnostic value of GICA used for intraoperative lymph node FNA-Tg measurement to evaluate thyroid cancer metastases Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Shaodong Hou, Yiceng Sun, Zeyu Yang, Mi Tang, Tingjie Yin, Cong Shao, Cunye Yan, Linlong Mo, Yuquan Yuan, Supeng Yin, Fan Zhang
Objective It is crucial to diagnose lymph node (LN) metastases (LNM) before or during thyroid carcinoma surgery. Measurement of thyroglobulin (Tg) in the fine needle aspirate washout (FNA-Tg) is useful to assist in the diagnosis of LNM for papillary thyroid carcinoma (PTC). This study aimed to assess the diagnostic performance of a new technique based on a colloidal gold-based immunochromatographic
-
Association of sensitivity to thyroid hormones with all-cause mortality in euthyroid US adults: a nationwide cohort study Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Genfeng Yu, Siyang Liu, Cheng Song, Qintao Ma, Xingying Chen, Yuqi Jiang, Hualin Duan, Yajun He, Dongmei Wang, Heng Wan, Jie Shen
Background This study aimed to examine the associations of thyroid hormone sensitivity indices, including free triiodothyronine-to-free thyroxine (FT3/FT4) ratio, thyroid feedback quantile-based index by FT4 (TFQIFT4), thyroid-stimulating hormone index (TSHI), and thyrotrophic thyroxine resistance index (TT4RI) with all-cause mortality in euthyroid adults. Methods The study included 6243 euthyroid
-
Real-world practice patterns and outcomes for RAI-refractory differentiated thyroid cancer Eur. Thyroid. J. (IF 4.7) Pub Date : 2024-02-01 Andrew G Gianoukakis, Jennifer H Choe, Daniel W Bowles, Marcia S Brose, Lori J Wirth, Taofeek Owonikoko, Svetlana Babajanyan, Francis P Worden
Background The optimal timing for initiating multi-kinase inhibitors (MKIs) in patients with radioactive iodine-refractory (RAI-R) differentiated thyroid cancer (DTC) remains unclear. Thus, we evaluated the real-world practice patterns and outcomes in asymptomatic patients with progressive RAI-R DTC (≥1 lesion ≥1 cm in diameter) in the USA (US population) and outside the USA (non-US population). Methods
-
Biochemical markers of renal function and maternal hypothyroidism in early pregnancy Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Lise Husted, Sidsel Rødgaard-Hansen, Maja Hjelm Lundgaard, Nanna Maria Uldall Torp, Stine Linding Andersen
Objective The physiological adaptations during a normal pregnancy affect renal and thyroid function and levels of associated biochemical markers. An association between cystatin C (CysC), creatinine, and thyroid function has been considered in nonpregnant individuals but not in pregnant women specifically. Methods Cohort study within the North Denmark Region Pregnancy Cohort (2011–2015) with assessment
-
Autonomously functioning thyroid nodules present intermediate malignancy risk according to European Thyroid Imaging Reporting and Data System (EU-TIRADS) and yield indeterminate cytology results Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Aglaia Kyrilli, Nunzia Tacelli, Lucia Russo, Laetitia Lebrun, Isabelle Salmon, Gilles Russ, Rodrigo Moreno-Reyes, Bernard Corvilain
Objectives The aim was to evaluate the clinical, ultrasound (US) and, when indicated, the cytological and histological characteristics of autonomously functioning thyroid nodules (AFTN) in consecutive patients. Methods A prospective, single-centre study was conducted between March 2018 and September 2021. In total, 901 consecutive patients were referred for thyroid workup and of 67 AFTN were evaluated
-
Characterization of thyroid metastasis from clear cell renal cell carcinoma on ultrasonography: a report of three cases and literature review Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Hai-Yan Jia, Juan Chen, Zi-Xin Zhai, Wen-Wen Fan, Si-Jie Yuan, Qiong Liu, Xiao-Hui Yan, Qian-Qian Shen, Li-Ping Liu
Introduction Thyroid metastasis from clear cell renal cell carcinoma (ccRCC) is relatively rare, so ultrasound doctors lack experience with the disease, which can easily lead to misdiagnosis. We describe three cases of thyroid metastasis from ccRCC detected 12, 8, and 7 years after nephrectomy. Case presentation The first patient, a 78-year-old woman, was admitted to our institution for hoarseness
-
Clinical factors for choosing active surveillance: an analysis of papillary thyroid microcarcinoma patients with recurrence Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Ho-Ryun Won, Min Gyu Kim, Min Soo Kim, Jae Won Chang, Bon Seok Koo
Objective Active surveillance (AS) has been suggested as a management option for low-risk papillary thyroid microcarcinoma (PTMC). However, the currently proposed selection criteria for AS application do not consider various clinical factors. The purpose of this study was to analyze clinical factors related to recurrence that could be confirmed preoperatively in patients who underwent surgery for PTMC
-
Effects of iodine status on thyroid volume and goiter in children living in an iodine-replete area Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Yun Jeong Lee, Young Hun Choi, Youn-Hee Lim, Bung-Nyun Kim, Johanna Inhyang Kim, Yun-Chul Hong, Young Joo Park, Choong Ho Shin, Sun Wook Cho, Young Ah Lee
Objective Adequate iodine intake is essential for growing children, and thyroid volume (Tvol) is considered as an indicator of iodine status. We investigated Tvol and goiter using ultrasonography (US) and their association with iodine status in 228 6-year-old children living in Korea. Methods Iodine status was assessed using urine iodine concentration (UIC) and categorized as deficient (<100 μg/L)
-
The sonographer’s and pathologist’s perspective of echogenic microfoci in papillary thyroid carcinoma Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Adile Begüm Bahçecioğlu, Alptekin Gürsoy, Serpil Dizbay Sak, Seyfettin Ilgan, Banu Bilezikçi, Murat Faik Erdoğan
Objective Punctate echogenic foci (PEF)/microcalcifications are thought to represent psammoma bodies (PB) in histopathology. However, there are few and contradictory data on this. Different types of sonographic echogenic microfoci (EMF) are seen in papillary thyroid carcinoma (PTC), and their histopathological equivalents are not clearly known. There is also conflicting data on the interobserver agreement
-
Significance of thyroperoxidase and thyroglobulin antibodies in medically treated Graves’ disease Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Stefan Matei Constantinescu, Julien Hospel, Chantal Daumerie, Orsalia Alexopoulou, Dominique Maiter, and Maria-Cristina Burlacu
Background Thyroperoxidase (TPOAb) and thyroglobulin (TgAb) antibodies are highly prevalent in Graves’ disease (GD), but their significance is controversial. Methods We retrospectively analyzed TPOAb and TgAb levels and evolution in 136 patients with newly diagnosed GD between 2000 and 2022, treated with anti-thyroid drugs (ATD) in a block-and-replace (B+R) regimen for at least 12 months and followed
-
Decreased hepatic thyroid hormone signaling in systemic and liver-specific but not brain-specific accelerated aging due to DNA repair deficiency in mice Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Sander Barnhoorn, Marcel E Meima, Robin P Peeters, Veerle M Darras, Selmar Leeuwenburgh, Jan H J Hoeijmakers, Wilbert P Vermeij, W Edward Visser
Background Thyroid hormone signaling is essential for development, metabolism, and response to stress but declines during aging, the cause of which is unknown. DNA damage accumulating with time is a main cause of aging, driving many age-related diseases. Previous studies in normal and premature aging mice, due to defective DNA repair, indicated reduced hepatic thyroid hormone signaling accompanied
-
A 20-year study of autoimmune polyendocrine syndrome type II and III in Taiwan Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Hsu-Hua Tseng, Yen-Bo Lin, Kuan-Yu Lin, Chia-Hung Lin, Hung-Yuan Li, Chia-Hsuin Chang, Yi-Ching Tung, Pei-Lung Chen, Chih-Yuan Wang, Wei-Shiung Yang, Shyang-Rong Shih
Purpose Autoimmune polyendocrine syndrome (APS) is a rare immune-endocrinopathy characterized by the failure of at least two endocrine organs. Clinical characteristics have mainly been described in the Western population. This study comprehensively analyzed the demographic and clinical manifestations of APS II and APS III in Taiwan. Methods Patients aged ≥20 years with a diagnosis of APS II or APS
-
European thyroid journal: passing on the baton. Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-11-08 S H S Pearce,L Persani
-
Mortality among papillary thyroid cancer patients by detection route: a hospital-based retrospective cohort study Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Lan Wu, Salvatore Vaccarella, Chen-Yang Feng, Luigino Dal Maso, Yu Chen, Wei-Wei Liu, Miao-Bian Liang, Zike Zhang, Jun Yang, Su-Mei Cao, Mengmeng Li
Background Incidence rates of papillary thyroid cancer (PTC) have increased rapidly, with incidentally detected cancers contributing a large proportion. We aimed to explore the impact of incidental detection on thyroid cancer-specific and competing mortality among PTC patients. Methods We conducted a retrospective cohort study of PTC patients at a cancer center in Guangzhou. Baseline information on
-
Hypothyroid women have persistently higher oxidative stress compared to healthy controls Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Kamilla R Riis, Camilla B Larsen, Bjarke R Medici, Christian Z Jensen, Kristian H Winther, Emil L Larsen, Christina Ellervik, Jeppe L la Cour, Laszlo Hegedüs, Thomas H Brix, Henrik E Poulsen, Filip K Knop, Birte Nygaard, Steen J Bonnema
Objective Some studies suggest that hypothyroidism is associated with increased oxidative stress. Urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) represents whole-body RNA and DNA oxidation, respectively. These biomarkers have only been explored sparsely in patients with thyroid disorders. Methods In 45 Danish women with newly diagnosed hypothyroidism
-
Optimizing the Dutch newborn screening for congenital hypothyroidism by incorporating amino acids and acylcarnitines in a machine learning-based model Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Heleen I Jansen, Marije van Haeringen, Marelle J Bouva, Wendy P J den Elzen, Eveline Bruinstroop, Catharina P B van der Ploeg, A S Paul van Trotsenburg, Nitash Zwaveling-Soonawala, Annemieke C Heijboer, Annet M Bosch, Robert de Jonge, Mark Hoogendoorn, Anita Boelen
Objective Congenital hypothyroidism (CH) is an inborn thyroid hormone (TH) deficiency mostly caused by thyroidal (primary CH) or hypothalamic/pituitary (central CH) disturbances. Most CH newborn screening (NBS) programs are thyroid-stimulating-hormone (TSH) based, thereby only detecting primary CH. The Dutch NBS is based on measuring total thyroxine (T4) from dried blood spots, aiming to detect primary
-
Influence of metabolic syndrome and lifestyle factors on thyroid nodules in Chinese adult men: a cross-sectional study Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Ziyu Wan, Ying Li, Xiaoqian Dong, Yue Kang, Juan Luo, Jiangang Wang, Pingting Yang, Yaqin Wang, Yinglong Duan, Jianfei Xie, Andy S K Cheng
Introduction Given the high prevalence of thyroid nodules and the potential for malignancy, it is imperative to understand the various factors that contribute to their development. This study aimed to explore the relationship between metabolic syndrome, lifestyle, and thyroid nodules in adult men in southern China. Methods This study enrolled a total of 183,990 subjects at a medical examination center
-
Usefulness of second 131I treatment in biochemical persistent differentiated thyroid cancer patients Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Carla Gambale, Alessandro Prete, Lea Contartese, Liborio Torregrossa, Francesca Bianchi, Eleonora Molinaro, Gabriele Materazzi, Rossella Elisei, Antonio Matrone
Background Second 131I treatment is commonly performed in clinical practice in patients with differentiated thyroid cancer and biochemical incomplete or indeterminate response (BiR/InR) after initial treatment. Objective The objective of the is study is to evaluate the clinical impact of the second 131I treatment in BiR/InR patients and analyze the predictive factors for structural incomplete response
-
Gestation-suppressed serum TSH levels during early pregnancy are not associated with altered maternal and neonatal outcomes Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Emna Jelloul, Georgiana Sitoris, Flora Veltri, Pierre Kleynen, Serge Rozenberg, Kris G Poppe
Objective The aim of the study was to investigate the impact of suppressed serum TSH levels (sTSH) during early pregnancy on maternal and neonatal outcomes. Methods In this single-centre, retrospective cohort study 1081 women were screened at 11.8 ± 2.4 weeks of pregnancy for TSH, free T4 (FT4) and TPOAb. Exclusion criteria were twin- and assisted- reproduction pregnancies, women with TSH levels >3
-
Unnecessary thyroid surgery rate for suspicious nodule in the absence of molecular testing Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Maria Mavromati, Essia Saiji, Marco Stefano Demarchi, Vincent Lenoir, Amanda Seipel, Paulina Kuczma, François R Jornayvaz, Minerva Becker, Eugenio Fernandez, Claudio De Vito, Frédéric Triponez, Sophie Leboulleux
Background Molecular tests for suspicious thyroid nodules decrease rates of unnecessary surgeries but are not widely used due to reimbursement issues. The aim of this study was to assess the rate of unnecessary surgery performed in real-life setting for Bethesda III, IV and V nodules in the absence of molecular testing. Method This is a single-center retrospective study of consecutive patients undergoing
-
Radiofrequency ablation for thyroid Bethesda III nodules: preliminary results Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Pi-Ling Chiang, Sheng-Dean Luo, Yen-Hsiang Chang, Chen-Kai Chou, Shun-Yu Chi, Yi-Fan Chen, Wei-Che Lin
Purpose The purpose of this study was to evaluate the feasibility of radiofrequency ablation (RFA) for thyroid nodules with cytological atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS, Bethesda III). Materials and methods A total of 28 adults presenting with 30 initial Bethesda III nodules underwent thyroid RFA at a single medical center. Thyroid nodules
-
Activation of mitogen-activated protein kinase signaling and development of papillary thyroid carcinoma in thyroid-stimulating hormone receptor D633H knockin mice Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Markus Eszlinger, Alexandra Stephenson, Shideh Mirhadi, Konrad Patyra, Michael F Moran, Moosa Khalil, Jukka Kero, Ralf Paschke
Objective Nonautoimmune hyperthyroidism (NAH) is rare and occurs due to a constitutively activating thyroid stimulating hormone receptor (TSHR) mutation. In contrast to other thyroid nodules, no further evaluation for malignancy is recommended for hot thyroid nodules. In the first model for NAH in mice nearly all homozygous mice had developed papillary thyroid cancer by 12 months of age. Methods To
-
A symptom-based algorithm for calcium management after thyroid surgery: a prospective multicenter study Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-12-01 Caroline M J van Kinschot, Ivona Lončar, Tessa M van Ginhoven, W Edward Visser, Robin P Peeters, Charlotte van Noord
Objective Evidence-based treatment guidelines for the management of postthyroidectomy hypocalcemia are absent. The aim of this study was to evaluate a newly developed symptom-based treatment algorithm including a protocolized attempt to phase out supplementation. Methods In a prospective multicenter study, patients were treated according to the new algorithm and compared to a historical cohort of patients
-
Circulating miR-146a predicts glucocorticoid response in thyroid eye disease Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-10-01 Jacopo Manso, Simona Censi, Cristina Clausi, Ilaria Piva, Yi Hang Zhu, Alberto Mondin, Maria Chiara Pedron, Susi Barollo, Loris Bertazza, Giulia Midena, Raffaele Parrozzani, Caterina Mian
Objective Thyroid eye disease (TED) is an immune-mediated disorder of the eye. Intravenous glucocorticoid (GC) is the first-line treatment for patients with active moderate-to-severe TED. However, the response rate is between 50% and 80%. There are still no simple and reliable markers of responsiveness to GC therapy. We aimed to explore the possible role of miR-146a and miR-21 as predictors of responsiveness
-
How low can we (reliably) go? A method comparison of thyroid-stimulating hormone assays with a focus on low concentrations Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-10-01 Stan R Ursem, Anita Boelen, Jacquelien J Hillebrand, Wendy P J den Elzen, Annemieke C Heijboer
Objective International guidelines concerning subclinical hyperthyroidism and thyroid cancer advice absolute cut-off values for aiding clinical decisions in the low range of thyroid-stimulating hormone (TSH) concentrations. As TSH assays are known to be poorly standardized in the normal to high range, we performed a TSH assay method comparison focusing on the low range. Methods Sixty samples, selected
-
Circadian clock disruption in autoimmune thyroiditis Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-10-01 Jinrong Fu, Zihao Fan, Liang He, Qian Liu, He Liu, Yushu Li, Haixia Guan
Objective A vicious cycle between circadian disruption and escalating immune responses has been described in diverse inflammatory disease. The current study aimed to explore the role of circadian clock disruption in autoimmune thyroiditis (AIT). Methods Thirty AIT patients and 30 controls were enrolled and biopsied for thyroid tissues. Alterations of core clock genes expression in AIT thyroid tissues
-
Bone metastases from differentiated thyroid cancer: characteristics and prognostic factors in a multicenter series Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-10-01 Ana Piñar-Gutiérrez, Ana R Romero-Lluch, Suset Dueñas-Disotuar, Irene de Lara-Rodríguez, María Ángeles Gálvez-Moreno, Tomás Martín-Hernández, Jorge García-Alemán, Guillermo Martínez-de Pinillos, Elena Navarro-González
Objective The aim of this study is to describe the characteristics, survival and prognostic factors of a cohort of patients with bone metastases (BMs) from differentiated thyroid carcinoma (DTC). Methods This was a multicenter retrospective observational study including patients diagnosed with BMs from DTC between 1980 and 2021. A Cox regression was performed to study prognostic factors for 5- and
-
2023 European Thyroid Association Clinical Practice Guidelines for thyroid nodule management Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-10-01 Cosimo Durante, Laszlo Hegedüs, Agnieszka Czarniecka, Ralf Paschke, Gilles Russ, Fernando Schmitt, Paula Soares, Tamas Solymosi, Enrico Papini
With the widespread use of sensitive imaging techniques, which include neck visualization, a conspicuous number of thyroid nodules emerge and demand attention. Most lesions are benign, asymptomatic, and do not warrant treatment. In the case of cancer diagnosis, most are small, intrathyroidal and indolent neoplasms that can safely be managed conservatively. There is a pronounced need for more cost-effective
-
The role of transducin β-like 1 X-linked receptor 1 (TBL1XR1) in thyroid hormone metabolism and action in mice Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-10-01 Yalan Hu, Kim Falize, A S Paul van Trotsenburg, Raoul Hennekam, Eric Fliers, Eveline Bruinstroop, Anita Boelen
Transducin β-like 1 X-linked receptor 1 (TBL1XR1) is a WD40 repeat-containing protein and part of the corepressor complex SMRT/NCoR that binds to the thyroid hormone receptor (TR). We recently described a mutation in TBL1XR1 in patients with Pierpont syndrome. A mouse model bearing this Tbl1xr1 mutation (Tbl1xr1Y446C/Y446C ) displays several aspects of the Pierpont phenotype. Although serum thyroid
-
Ethanol ablation of thyroid cysts in the young with a focus on efficacy and quality of life Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-08-11 Milan Halenka, Hana Munteanu, Radko Obereigneru, Roman Dohnal, David Karasek, Jan Schovanek
Objective Ultrasound-guided percutaneous ethanol injection therapy (US-PEIT) is used in patients with recurrent symptomatic thyroid cysts as a credible alternative to surgery. Young patients commonly do not wish to undergo surgery and prefer ethanol ablation, if available. The effect of this approach on quality of life is an essential factor in deciding on the treatment options, especially in the young
-
Longitudinal trajectories of maternal TSH in healthy pregnant women in Catalonia Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-08-11 Berta Soldevila, Inés Velasco, Carla Muñoz, Yesika Díaz, Laia Egea-Cortés, Laura Ferrer-Escopiñan, Alejandra Pérez-Montes de Oca, Raquel Martínez-Mondejar, Jordi Casabona, Manel Puig-Domingo
Objective Longitudinal evaluation of thyroid function throughout pregnancy in the same subject could offer precise information about its dynamics as a physiological mechanism of adaption to the requirements. In this study, we evaluated longitudinal trajectories of maternal thyroid function during pregnancy by a latent class growth analysis and explored their association with maternal–fetal outcomes
-
Improvement in neck ultrasound report quality following the implementation of European Thyroid Association guidelines for postoperative cervical ultrasound for thyroid cancer follow-up, a prospective population study Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-08-11 Jiahui Wu, Xunyang Hu, Paula Seal, Parthiv Amin, Brendan Diederichs, Ralf Paschke
Objective The aim of this study was to prospectively evaluate the quality of postoperative neck ultrasound (POU) for thyroid cancer patients after implementing European Thyroid Association (ETA) guideline-based POU assessment. Methods Our analysis involved 672 differentiated thyroid cancer patients. POU report quality was compared between the implementation radiology group (IRG), which implemented
-
Use of lenvatinib in the treatment of radioiodine-refractory differentiated thyroid cancer: a multidisciplinary perspective for daily practice Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-08-08 Jaume Capdevila, Desiree’ Deandreis, Cosimo Durante, Sophie Leboulleux, Markus Luster, Romana Netea-Maier, Kate Newbold, Susanne Singer, Gerasimos P Sykiotis, Beate Bartes, Kate Farnell, Laura Deborah Locati
Background Most thyroid cancers of follicular origin have a favorable outcome. Only a small percentage of patients will develop metastatic disease, some of which will become radioiodine refractory (RAI-R). Important challenges to ensure the best therapeutic outcomes include proper, timely, and appropriate diagnosis; decisions on local, systemic treatments; management of side effects of therapies; and
-
Iodine avidity in papillary and poorly differentiated thyroid cancer is predicted by immunohistochemical and molecular work-up Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-07-28 Joachim N Nilsson, Jonathan Siikanen, Vincenzo Condello, Kenbugul Jatta, Ravi Saini, Christel Hedman, Catharina Ihre Lundgren, C Christofer Juhlin
Background Successful radioiodine treatment of differentiated thyroid cancer requires iodine avidity: that is, the concentration and retention of iodine in cancer tissue. Several parameters have previously been linked with lower iodine avidity. However, a comprehensive analysis of which factors best predict iodine avidity status, and the magnitude of their impact, is lacking. Methods Quantitative measurements
-
Central hyperthyroidism combined with Graves' disease: case series and review of the literature Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-07-28 Caiyan Mo, Han Chen, Qi Zhang, Ying Guo, Liyong Zhong
Background Central hyperthyroidism is characterized by elevated free thyroid hormone and unsuppressed thyroid-stimulating hormone (TSH), and this laboratory feature includes TSH-secreting pituitary adenoma (TSHoma) and resistance to thyroid hormone β (RTHβ). Central hyperthyroidism combined with Graves’ disease (GD) has been rarely reported. Case Report We describe three patients with TSHoma combined
-
Neonatal screening for primary and central congenital hypothyroidism: is it time to go Dutch? Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-07-27 Anita Boelen, Nitash Zwaveling-Soonawala, Annemieke C Heijboer, A S Paul van Trotsenburg
Thyroid hormone (TH) is indispensable for brain development in utero and during the first 2–3 years of life, and the negative effects of TH deficiency on brain development are irreversible. Detection of TH deficiency early in life by neonatal screening allows early treatment, thereby preventing brain damage. Inborn shortage of TH, also named congenital hypothyroidism (CH), can be the result of defective
-
Metabolomic profile of patients on levothyroxine treatment for hypothyroidism Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-07-27 Hicham Benabdelkamel, Malak A Jaber, Lina A Dahabiyeh, Afshan Masood, Reem H Almalki, Mohthash Musambil, Anas M Abdel Rahman, Assim A Alfadda
Background Hypothyroidism is clinically characterized by a decrease in levels of the circulating thyroid hormones namely thyroxine and triiodothyronine. The main treatment for hypothyroidism is thyroid hormone replacement using levothyroxine to normalize serum thyroid hormone levels. Objectives In this study, we explored the metabolic changes in the plasma of patients with hypothyroidism after reaching
-
Trends in radioactive iodine treatment after total thyroidectomy in Italy, 2001–2018 Eur. Thyroid. J. (IF 4.7) Pub Date : 2023-07-12 Luigino Dal Maso, Daniela Pierannunzio, Silvia Francisci, Angela De Paoli, Federica Toffolutti, Salvatore Vaccarella, Silvia Franceschi, Rossella Elisei, Ugo Fedeli
Objective A decrease in the use of radioactive iodine (RAI) treatment for thyroid cancer has been described in the last decade in the US following subsequent updates of the American Thyroid Association guidelines. By contrast, population-based data from European countries are lacking. The study aims to assess the frequency and long-term trends in the use of RAI in Italy. Methods From the Italian national