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The Pathophysiological Associations Between Obesity, NAFLD, and Atherosclerotic Cardiovascular Diseases Horm. Metab. Res. (IF 2.2) Pub Date : 2024-03-12 Meng Li, Man Cui, Guoxia Li, Yueqiu Liu, Yunsheng Xu, Seyed Parsa Eftekhar, Moein Ala
Obesity, non-alcoholic fatty liver disease (NAFLD), and atherosclerotic cardiovascular diseases are common and growing public health concerns. Previous epidemiological studies unfolded the robust correlation between obesity, NAFLD, and atherosclerotic cardiovascular diseases. Obesity is a well-known risk factor for NAFLD, and both of them can markedly increase the odds of atherosclerotic cardiovascular
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The Adrenal Gland and Pancreatic Islets – A Beneficial Endocrine Alliance Horm. Metab. Res. (IF 2.2) Pub Date : 2024-03-12
Intraportal islet transplantation in patients with type 1 diabetes enables restoration of glucose-regulated insulin secretion. However, several factors hamper a widespread application and long-term success: chronic hypoxia, an inappropriate microenvironment and suppression of regenerative and proliferative potential by high local levels of immunosuppressive agents. Therefore, the identification of
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Association of VEGF+936 C/T Polymorphism with Susceptibility to Type 2 Diabetic Retinopathy: A Meta-Analysis Horm. Metab. Res. (IF 2.2) Pub Date : 2024-03-12 Yanhong Huo, Xin Zhang, Li Su, Yan Zhang
The objective of this study is to explore the relationship between the vascular endothelial growth factor (VEGF)+936 C/T polymorphism and the risk of type 2 diabetic retinopathy (T2DR) by a method of meta-analysis. Six online databases were queried to identify studies investigating the VEGF+936 C/T polymorphism that influenced T2DR up to August 2023. The statistical tool of the pooled data was adopted
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Recent Advances in Molecular Pathways and Therapeutic Implications for Peptic Ulcer Management: A Comprehensive Review Horm. Metab. Res. (IF 2.2) Pub Date : 2024-03-11 Deepak Chandra Joshi, Nirmal Joshi, Ajeet Kumar, Shubhrat Maheshwari
Peptic ulcers, recognized for their erosive impact on the gastrointestinal mucosa, present a considerable challenge in gastroenterology. Epidemiological insights underscore the global prevalence of peptic ulcers, affecting 5–10+% of individuals, with a yearly incidence of 0.3 to 1.9 cases per thousand. Recent decades have witnessed a decline in complications, attributed to improved diagnostics and
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Dysregulation of miR-335-5p in People with Obesity and its Predictive Value for Metabolic Syndrome Horm. Metab. Res. (IF 2.2) Pub Date : 2024-03-06 Lu Liting, He Yufeng
The epidemic of obesity and metabolic syndrome has become the most serious global public health problem. The part played by microRNA (miRNA) in the onset and progression of obesity and metabolic syndrome has been increasingly focused upon. The goal of this study was to explore miR-335-5p as a potential predictive biomarker or therapeutic target for obesity and metabolic syndrome. The expression level
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Relationship Between Urinary Iodine Concentration and the Prevalence of Thyroid Nodules and Subclinical Hypothyroidism Horm. Metab. Res. (IF 2.2) Pub Date : 2024-03-06 Huachao Zhu, Pu Chen, Xi Ding, Yanru Zhao
The aim of the study was to investigate the iodine intake in the resident population in Xi’an and analyze the relationship between iodine nutritional status and the prevalence of subclinical hypothyroidism and thyroid nodules (TNs). A total of 2507 people were enrolled in Xi’an. Venous serum thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb), urinary
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Salivary Cortisol Measurement Contamination After Oral Hydrocortisone: A Randomized Crossover Trial Horm. Metab. Res. (IF 2.2) Pub Date : 2024-03-06 Melika Chihaoui, Yasmine Mouelhi, Bessem Hammami, Ibtissem Oueslati, Nadia Khessairi, Fatma Chaker, Meriem Yazidi, Moncef Feki
The study aimed to evaluate salivary cortisol (SC) contamination and determine the associated factors in secondary adrenal insufficiency (SAI) patients treated with hydrocortisone (Hc). A randomized crossover trial involved SAI patients. SC was measured before the morning Hc dose, then at one, two, and four hours after. The procedure was performed twice on two days of a week: one day while taking Hc
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Glucocorticoid-Induced Myopathy: Typology, Pathogenesis, Diagnosis, and Treatment Horm. Metab. Res. (IF 2.2) Pub Date : 2024-03-04 Mengmeng Wu, Caixia Liu, Dong Sun
Glucocorticoid-induced myopathy is a non-inflammatory toxic myopathy typified by proximal muscle weakness, muscle atrophy, fatigue, and easy fatigability. These vague symptoms coupled with underlying disorders may mask the signs of glucocorticoid-induced myopathy, leading to an underestimation of the disease’s impact. This review briefly summarizes the classification, pathogenesis, and treatment options
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Preservation of β-Cells as a Therapeutic Strategy for Diabetes Horm. Metab. Res. (IF 2.2) Pub Date : 2024-02-22 Jalal Taneera, Maha M. Saber-Ayad
The preservation of pancreatic islet β-cells is crucial in diabetes mellitus, encompassing both type 1 and type 2 diabetes. β-cell dysfunction, reduced mass, and apoptosis are central to insufficient insulin secretion in both types. Research is focused on understanding β-cell characteristics and the factors regulating their function to develop novel therapeutic approaches. In type 1 diabetes (T1D)
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Revealing Melatonin’s Mysteries: Receptors, Signaling Pathways, and Therapeutics Applications Horm. Metab. Res. (IF 2.2) Pub Date : 2024-02-19 Kulsoom Kulsoom, Wajahat Ali, Zainab Saba, Shabab Hussain, Samra Zahra, Maria Irshad, Muhammad Saeed Ramzan
Melatonin (5-methoxy-acetyl tryptamine) is a sleep-inducing hormone, and the pineal gland produces it in response to the circadian clock of darkness. In the body, MT1 and MT2 receptors are mostly found, having an orthosteric pocket and ligand binding determinants. Melatonin acts by binding on melatonin receptors, intracellular proteins, and orphan nuclear receptors. It inhibits adenyl cyclase and activates
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Energy Metabolism in Residents in the Low- and Moderate Altitude Regions of Central Asia with MAFLD and Type 2 Diabetes Mellitus Horm. Metab. Res. (IF 2.2) Pub Date : 2024-02-19 Nurgul Toktogulova, Matthias Breidert, Judith Eschbach, Indira Kudaibergenova, Uulkan Omurzakova, Feruzakhan Uvaidillaeva, Bermet Tagaeva, Roza Sultanalieva, Pierre Eftekhari
The knowledge about the features of energy metabolism in MAFLD in the population living at different climatic and geographic heights is lacking. The goal of this study is to explore the biochemical parameters of blood and erythrocyte energy consumption in patients with MAFLD with and without DM2 living in the low- and moderate-altitude regions of Central Asia. Our study was carried out on patients
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Utility of Simple and Non-Invasive Strategies Alternative to Inferior Petrosal Sinus Sampling and Peripheral CRH Stimulation in Differential Diagnosis of ACTH-Dependent Cushing Syndrome Horm. Metab. Res. (IF 2.2) Pub Date : 2024-02-16 Bhawna Attri, Alpesh Goyal, Mani Kalaivani, Devasenathipathy Kandasamy, Yashdeep Gupta, Shipra Agarwal, Shamim A. Shamim, Nishikant Damle, Mehar Chand Sharma, Viveka P. Jyotsna, Ashish Suri, Nikhil Tandon
We aimed to evaluate the utility of simple, cost-effective, and non-invasive strategies alternative to BIPSS and peripheral CRH stimulation in differential diagnosis of ACTH-dependent CS. First, we performed ROC analysis to evaluate the performance of various tests for differential diagnosis of ACTH-dependent CS in our cohort (CD, n=76 and EAS, n=23) and derived their optimal cut-offs. Subsequently
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Elevated Levels of Interleukin-18 are Associated with Lymph Node Metastasis in Papillary Thyroid Carcinoma Horm. Metab. Res. (IF 2.2) Pub Date : 2024-02-14 Wang Chun, Meiyin Lu, Jiakang Chen, Jian Li
Interleukin-18 (IL-18) is a proinflammatory cytokine that primarily stimulates the Th1 immune response. IL-18 exhibits anticancer activity and has been evaluated in clinical trials as a potential cancer treatment. However, evidence suggests that it may also facilitate the development and progression of some cancers. So far, the impact of IL-18 on papillary thyroid cancer (PTC) has not been investigated
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Targeting Abnormal Tau Phosphorylation for Alzheimer’s Therapeutics Horm. Metab. Res. (IF 2.2) Pub Date : 2024-02-13 Aditya Singh, Vaseem Ahamad Ansari, Tarique Mahmood, Syed Misbahul Hasan, Rufaida Wasim, Shubhrat Maheshwari, Juber Akhtar, Suvaiv Sheikh, Vishal Kumar Vishwakarma
Alzheimer’s disease (AD) is a widespread neurodegenerative disorder characterized by progressive memory and cognitive decline, posing a formidable public health challenge. This review explores the intricate interplay between two pivotal players in AD pathogenesis: β-amyloid (Aβ) and tau protein. While the amyloid cascade theory has long dominated AD research, recent developments have ignited debates
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Potassium: A Frontier in Osteoporosis Horm. Metab. Res. (IF 2.2) Pub Date : 2024-02-12 Widhilika Singh, Poonam Kushwaha
Osteoporosis is a significant public health concern, particularly in aging populations, leading to fractures, decreased mobility, and reduced quality of life. While calcium and vitamin D have long been recognized as essential for bone health, emerging research suggests that potassium may play a crucial role in maintaining bone density and preventing osteoporosis. This manuscript explores the relationship
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The Evolution of the Bone Turnover Marker in Patients Following Recovery from Diabetic Ketoacidosis Horm. Metab. Res. (IF 2.2) Pub Date : 2024-02-12 Song Wen, Chenglin Xu, Yue Yuan, Yanyan Li, Dongxiang Xu, Min Gong, Mingyue Zhou, Ligang Zhou
The aim of the study was to investigate whether the biomarkers for bone turnover could rapidly recover during the period of diabetic ketoacidosis (DKA). Bone turnover biomarkers, including 25-hydroxyvitamin D3, N-terminal middle molecular fragment of osteocalcin (NMID), and β-C terminal cross-linking telopeptide of type 1 collagen were evaluated using in-patient data (n=627) from Shanghai Pudong Hospital
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Association of Red Blood Cell and Platelet Parameters with Metabolic Syndrome: A Systematic Review and Meta-Analysis of 170,000 Patients Horm. Metab. Res. (IF 2.2) Pub Date : 2024-02-12 Aysal Mahmood, Saba Samad, Hoorain Haider, Wardah Hassan, Rabeea Mushtaq, Aimen Perwaiz, Abraish Ali, Muhammad Azharuddin
This systematic review and meta-analysis aim to establish associations between metabolic syndrome (MetS) and erythrocyte and platelet markers, contributing to improved diagnostic tests for identifying individuals at risk. Observational studies and Randomized Controlled Trials (RCTs) were included. The standardized mean difference (SMD) and 95% confidence intervals (CI) of erythrocyte and platelet markers
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Meta-Analysis and Network Analysis Differentially Detect Various Pro-Inflammatory Mediators and Risk Factors for Type 2 Diabetes in the Elderly Horm. Metab. Res. (IF 2.2) Pub Date : 2024-02-12 Linlin Gu, Yue Du, Fang Liang
Type 2 diabetes (T2D) has a pathophysiological component that includes inflammation. Inflammation-sensitive marker measurement may be helpful in determining the risk of complications for both older T2D patients and the public. This study aimed to investigate the association between blood pro-inflammatory mediators and the characteristics of elderly patients with T2D using meta and network analyses
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ETV5 Silencing Produces Mesenchymal to Epithelial Transition in INS-1 (832/13) Cell Line Horm. Metab. Res. (IF 2.2) Pub Date : 2024-02-09
ETV5 has been described to be involved in the epithelial to mesenchymal transition (EMT) mainly in cancer. It is known that EMT provokes cytoskeleton remodeling, improving cellular migratory, and invasive capabilities. Moreover, overexpression of ETV5 has been correlated to cancer development and this gene has been implicated in cell proliferation. However, little is known about the downregulation
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Ferroptosis: A Frontier in Osteoporosis Horm. Metab. Res. (IF 2.2) Pub Date : 2024-02-02 Shubhrat Maheshwari, Aditya Singh, Amita Verma
Reduced bone mass and degeneration of the microarchitecture of bone tissue are the hallmarks of osteoporosis, a bone metabolic disease that increases skeletal fragility and fracture susceptibility. Osteoporosis is primarily caused by unbalanced bone remodeling, in which bone synthesis is outpaced by bone resorption caused by osteoclasts. Along with the bone-building vitamins calcium and vitamin D,
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Periostin Promotes the Proliferation, Differentiation and Mineralization of Osteoblasts from Ovariectomized Rats Horm. Metab. Res. (IF 2.2) Pub Date : 2024-02-02 Jun Yan, Zidong Wang, Li Xian, Dawei Wang, Yunzhen Chen, Jie Bai, Hai-juan Liu
Perimenopausal period causes a significant amount of bone loss, which results in primary osteoporosis (OP). The Periostin (Postn) may play important roles in the pathogenesis of OP after ovariectomized (OVX) rats. To identify the roles of Postn in the bone marrow mesenchymal stem cell derived osteoblasts (BMSC-OB) in OVX rats, we investigated the expression of Wnt/β-catenin signaling pathways in BMSC-OB
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Maternal Gestational Diabetes Mellitus and Congenital Heart Disease in Offspring: A Meta-Analysis Horm. Metab. Res. (IF 2.2) Pub Date : 2024-02-02 Yun Liu, Lina Yue, Li Chang
Maternal diabetes has been related to an increased risk of congenital heart disease (CHD) in offspring. However, inconsistent results were retrieved for studies evaluating the association between gestational diabetes mellitus (GDM) and CHD in offspring. We therefore performed a systematic review and meta-analysis for comprehensive investigation. Observational studies were identified by searching PubMed
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The N-Methyl-D-Aspartate Receptor Antagonist Dextromethorphan Improves Glucose Homeostasis and Preserves Pancreatic Islets in NOD Mice Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-29 Laura Wörmeyer, Oliver Nortmann, Anna Hamacher, Celina Uhlemeyer, Bengt Belgardt, Daniel Eberhard, Ertan Mayatepek, Thomas Meissner, Eckhard Lammert, Alena Welters
For treatment of type 1 diabetes mellitus, a combination of immune-based interventions and medication to promote beta-cell survival and proliferation has been proposed. Dextromethorphan (DXM) is an N-methyl-D-aspartate receptor antagonist with a good safety profile, and to date, preclinical and clinical evidence for blood glucose-lowering and islet-cell-protective effects of DXM have only been provided
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Hsa_circ_0092355 Accelerates Papillary Thyroid Cancer Progression by Regulating the miR-543/PDE5A Pathway Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-29 Zhijun Sun, Min Zhang, Yangmei Ye, Leilei Yang
CircRNAs have been found to participate in the progression of various tumors. In the present study, we aimed to clarify the role of hsa_circ_0092355 in papillary thyroid cancer (PTC) cell development. RT-qPCR was used to determine the expression of hsa_circ_0092355, miR-543, and PDE5A. PTC cell proliferation was ascertained via a cell colony formation assay and the CCK-8 test. Western blotting was
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HINT2 may be One Clinical Significance Target for Patient with Diabetes Mellitus and Reduced ROS-Induced Oxidative Stress and Ferroptosis by MCU Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-29 Mei Bai, Wei Lu, Jun Tan, Xin Mei
The World Health Organization (WHO) predicted that patients with diabetes around the world will increase to 600 million by 2040, of which about 1/3 will develop diabetic nephropathy (DN). Therefore, the present study aimed to uncover therapeutic effect of HINT2 and determined its possible mechanisms. Patients with diabetes mellitus and normal volunteers were enrolled at our hospital. Male C57BL/6 mice
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Quality Evaluation of Metabolic-Associated Fatty Liver Disease Guidelines and Expert Consensus Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-29 Meijing Chen, Ying Chen, Dun Liu, Ka Li, Rong Hu, Jingyi Chen, Xiaoying Jiang, Jinqing Lin
The purpose of this study is to evaluate and analyze the quality of guidelines and expert consensus on clinical practice regarding metabolically associated fatty liver disease (MAFLD) over the past five years. Data from the websites were retrieved using computers. We evaluated guidelines and expert consensus on MAFLD that were officially published between January 1, 2018 and March 24, 2023. Two evaluators
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Thyroid Inflammation and Immunity During the COVID-19 Pandemic: A Comprehensive Review and Case Study Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-29
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the development of various vaccines. Reports have emerged suggesting a possible association between SARS-CoV-2 vaccination and the onset of thyroid diseases. This review explores the clinical aspects of thyroid disorders following SARS-CoV-2 vaccination, including a case
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Meta-Analysis of the Efficacy and Safety Evaluation of Vandetanib in the Treatment of Medullary Thyroid Cancer Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-26 Tong-cheng Xian, Min-ye Yang, Xue-lin Zhang, Jie Wang, Yi Luo
The aim of the work was to systematically evaluate the efficacy and safety of Vandetanib in the treatment of advanced medullary thyroid carcinoma (MTC). MeSH entries to search for randomized controlled trials and clinical research literature on the application of Vandetanib in the treatment of medullary thyroid cancer from PubMed, Chinese national knowledge infrastructure (CNKI), and Web of Science
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Association Between VEGF-460C/T Gene Polymorphism and Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus: A Meta-Analysis Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-25 Bo Cheng, Aimin Wu, Xuewei Zhou
The aim of the study was to investigate the relationship between VEGF-460C/T polymorphism and susceptibility to diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) by meta-analysis. A comprehensive search was conducted across six databases until September 2023 to identify studies examining the association between VEGF-460C/T polymorphism and susceptibility to DR. Data process was performed
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Renal Function Evolution and Hypoaldosteronism Risk After Unilateral Adrenalectomy for Primary Aldosteronism Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-22 Nara L. Queiroz, Matheo A. M. Stumpf, Victor C. M. Souza, Ana Alice W. Maciel, Gustavo F. C. Fagundes, Jessica Okubo, Victor Srougi, Fabio Y. Tanno, Jose L. Chambo, Maria Adelaide A. Pereira, Andrea Pio-Abreu, Luiz A. Bortolotto, Ana Claudia Latronico, Maria Candida Barisson Villares Fragoso, Luciano F. Drager, Berenice B. Mendonça, Madson Q. Almeida
Few studies demonstrated a percentage decrease in the estimated glomerular filtration rate (eGFR) at a single time and the rate of hypoaldosteronism after adrenalectomy for primary aldosteronism (PA). Our aim was to investigate the evolution of renal function and the hypoaldosteronism risk after adrenalectomy for PA. Aldosterone, renin, eGFR, and electrolyte levels were determined before and at 1 week
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Characteristics of Ovarian Cancer Immune Cell Invasion and Bioinformatics to Predict the Effect of Immunotherapy Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-19 Lingli Yan, Erxi Fan, Bin Tan
Recent studies have confirmed that tumor immune cell infiltration (ICI) is associated with sensitivity of ovarian cancer (OC) immunotherapy and disease progression of OC patients. However, studies related to immune infiltration in OC, has not been elucidated. Two algorithms are used to analyze the OC data in the TCGA and GEO databases. After combining the two data sets, the immune cell content of the
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Anthropometric, Metabolic, and Endocrine Parameters as Predictors of Estimated Average Glucose and Other Biomarkers of Dysglycemia in Women with Different Phenotypes of Polycystic Ovary Syndrome Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-10 Sebastião Freitas de Medeiros, Ana Lin Winck Yamamoto de Medeiros, Matheus Antônio Souto de Medeiros, Anna Bethany da Silva Carvalho, Marcia W. Yamamoto, José M. Soares, Edmund C. Baracat
The aim of the study was to evaluate the efficacy of anthropometric, metabolic, and endocrine abnormalities as predictors of estimated average glucose and other biomarkers of dysglycemia in women with different phenotypes of polycystic ovary syndrome (PCOS). This cross-sectional study included 648 women with PCOS and 330 controls. A single protocol of investigation was applied for all subjects. PCOS
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Risk Factors Analysis of Severe Liver Injury Induced by Statins Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-03 Feng-yun Su, Wen-hua Li, Xu-dong Zhao, Qian Han, Xin Xu, Tao Geng
The aim of this study is to report the risk factors of severe statin induced liver injury (SILI). From the database of Shandong ADR Monitoring Center and Outpatients and inpatients in our hospital, SILI cases reported from 2013 to 2021 were extracted and screened. The diagnostic criteria of SILI, the inclusion and exclusion criteria of severe and general SILI were established separately. After the
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Current Evidence on Local Therapies in Advanced Adrenocortical Carcinoma Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-03 Otilia Kimpel, Ulrich Dischinger, Barbara Altieri, Carmina Teresa Fuss, Bülent Polat, Ralph Kickuth, Matthias Kroiss, Martin Fassnacht
International guidelines emphasise the role of local therapies (LT) for the treatment of advanced adrenocortical carcinoma (ACC). However, large studies are lacking in this field. Therefore, we performed a review of the literature to synthesise current evidence and develop clinical guidance. PubMed database was searched for systematic literature. We identified 119 potentially relevant articles, of
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Endocrine Disruptors: Focus on the Adrenal Cortex Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-03 Benedikt Pötzl, Lydia Kürzinger, Helga Stopper, Martin Fassnacht, Max Kurlbaum, Ulrich Dischinger
Endocrine-disrupting chemicals (EDCs) are exogenous substances known to interfere with endocrine homeostasis and promote adverse health outcomes. Their impact on the adrenal cortex, corticosteroids and their physiological role in the organism has not yet been sufficiently elucidated. In this review, we collect experimental and epidemiological evidence on adrenal disruption by relevant endocrine disruptors
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Sensitivity of the Neuroendocrine Stress Axis in Metabolic Diseases Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-03 Diana Cozma, Panagiota Siatra, Stefan R. Bornstein, Charlotte Steenblock
Metabolic diseases are prevalent in modern society and have reached pandemic proportions. Metabolic diseases have systemic effects on the body and can lead to changes in the neuroendocrine stress axis, the critical regulator of the body’s stress response. These changes may be attributed to rising insulin levels and the release of adipokines and inflammatory cytokines by adipose tissue, which affect
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Animal and Cell Culture Models of PPGLs – Achievements and Limitations Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-03 Bhargavi Karna, Natalia Simona Pellegata, Hermine Mohr
Research on rare tumors heavily relies on suitable models for basic and translational research. Paragangliomas (PPGL) are rare neuroendocrine tumors (NET), developing from adrenal (pheochromocytoma, PCC) or extra-adrenal (PGL) chromaffin cells, with an annual incidence of 2–8 cases per million. While most PPGL cases exhibit slow growth and are primarily treated with surgery, limited systemic treatment
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Quantitative Characterization of Ectopic Adrenal Gene Expression in Fetal Testes in 21-Hydroxylase Deficient Mice Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-03
Testicular adrenal rest tumors (TART) are a frequent and fertility impairing long-term complication in males with classic congenital adrenal hyperplasia. Due to lack of clear experimental data on their origin, they are hypothesized to be derived from ectopic adrenocortical cells within testicular tissue mainly growing upon stimulation by chronically elevated levels of adrenocorticotropin (ACTH). Alternatively
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Transition from Paediatric to Adult Care in CAH: 20 Years of Experience at a Tertiary Referral Center Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-03 Cordula Kiewert, Julia Jedanowski, Berthold P. Hauffa, Stephan Petersenn, Klaus Mann, Dagmar Führer, Nicole Unger
Transition medicine aims at the coordinated transfer of young patients with a chronic disease from paediatric to adult care. The present study reflects 20 years of experience in transitioning patients with congenital adrenal hyperplasia (CAH) in a single center setting. Our endocrine transition-clinic was established in 2002 and offers joint paediatric and adult consultations. Data were evaluated retrospectively
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Morbidity in Patients with Chronic Adrenal Insufficiency – Cardiovascular Risk Factors and Hospitalization Rate Compared to Population Based Controls Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-03 Irina Chifu, Marcus Quinkler, Barbara Altieri, Anke Hannemann, Henry Völzke, Katharina Lang, Nicole Reisch, Christina Pamporaki, Holger Sven Willenberg, Felix Beuschlein, Stephanie Burger-Stritt, Stefanie Hahner
Patients with adrenal insufficiency (AI) have been found to have increased cardiovascular morbidity, partly associated with nonphysiologic glucocorticoid replacement. We included two separate cohorts (cohort 1 n=384 patients, cohort 2 n=180 patients) of patients with chronic primary and secondary AI under standard replacement therapy and compared them to two age- and sex-matched population-based studies
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The Adrenal Gland: A Fascinating Object of Research and Clinical Care Showcased at the 15th German Adrenal Conference in Dresden Horm. Metab. Res. (IF 2.2) Pub Date : 2024-01-03 Matthias Kroiss, Nicole Bechmann
Dear colleagues, When younger fellows ask for guidance on how to choose a research project, many aspects require consideration: how to select a supervisor and mentor, should one change the institution, how does the project boost the later professional career, what are personal and professional aims. As many can probably relate it is passion for the research topic, both by the fellow and the mentor
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The Presence of Anti-TPO Antibodies Increase the Likelihood of Post-I131 Hypothyroidism Horm. Metab. Res. (IF 2.2) Pub Date : 2023-12-19 Felix Quataert, Bert Bravenboer, Marleen Keyaerts, Corina Emilia Andreescu
The use of radioactive iodine in the treatment of hyperthyroidism is common practice. However, a standardized treatment protocol with regard to radioactive iodine treatment (RAI) remains subject to discussion. We retrospectively analyzed 100 patient records. Patient diagnosis, age, gender, body mass index (BMI), dose of radioactive iodine, thyroid size, the 24 h radioiodine uptake (24 h RAIU) and protein
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Identification of Key Genes and Related Drugs of Adrenocortical Carcinoma by Integrated Bioinformatics Analysis Horm. Metab. Res. (IF 2.2) Pub Date : 2023-12-18 Jian-bin Wei, Xiao-chun Zeng, Kui-rong Ji, Ling-yi Zhang, Xiao-min Chen
Adrenocortical carcinoma (ACC) is a malignant carcinoma with an extremely poor prognosis, and its pathogenesis remains to be understood to date, necessitating further investigation. This study aims to discover biomarkers and potential therapeutic agents for ACC through bioinformatics, enhancing clinical diagnosis and treatment strategies. Differentially expressed genes (DEGs) between ACC and normal
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Expression and Role of PDK4 on Childhood Dyslipidemia and Lipid Metabolism in Hyperlipidemic Mice Horm. Metab. Res. (IF 2.2) Pub Date : 2023-12-14 Wenjuan Cai, Xin Wang, Qian Deng, Jian Gao, Yuqing Chen
Hyperlipidemia is a common metabolic disorder that can lead to cardiovascular disease. PDK4 is a key enzyme that regulates glucose and fatty acid metabolism and homeostasis. The aim of this study is to explore the correlation between PDK4 expression and dyslipidemia in obese children, and to find new therapeutic targets for hyperlipidemia in children. The expression of PDK4 in serum was detected by
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The Fate of Angiotensin II in Placental Tissue and Blood Horm. Metab. Res. (IF 2.2) Pub Date : 2023-12-11 Shigehiko Mizutani, Hidesuke Mizutani, Eita Mizutani, Harumasa Arita, Hiroaki Kajiyama
The existence of a non-canonical pathway of renin-angiotensin system in the blood pressure control system has been highlighted over the past three decades. The enzymes involved in this pathway include a series of angiotensinases such as neprilysin (NEP), aminopeptidase A (APA), carboxypeptidase, and angiotensin converting enzyme 2. The physiological roles of these peptidases have been reconsidered
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Metabolic Syndrome Components in Patients with Pituitary Adenoma Horm. Metab. Res. (IF 2.2) Pub Date : 2023-12-11
Pituitary adenomas are benign tumors of the anterior portion of the pituitary gland (adenohypophysis), representing the 25% of all the tumor alterations. Pituitary adenomas are classified by the type of hormone secreted, cellularity, size, and structural alterations by the hormonal segregation. The diagnosis consists on the histopathological identification of cell types and the image-guided by magnetic
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Unawareness of Primary Aldosteronism as a Common Cause of Hypokalemia – Insights from the IPAHK+ Trial (Incidence of Primary Aldosteronism in Patients with Hypokalemia) Horm. Metab. Res. (IF 2.2) Pub Date : 2023-12-11 Sven Gruber, Evangelia Stasi, Antonio Boan Pion, Regula Steiner, Zoran Erlic, Stefan R. Bornstein, Isabella Sudano, Martin Reincke, Felix Beuschlein
Hypokalemia plays an important role in the diagnosis and management of primary aldosteronism (PA). While the hypokalemic variant of the disease accounts for about one third of all cases, little is known about the incidence of PA in hypokalemic populations. The IPAHK+ study is an epidemiological, cross-sectional trial to provide evidence on the incidence of PA in hypokalemic patients from a university
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FAF1 Gene Involvement in Pituitary Corticotroph Tumors Horm. Metab. Res. (IF 2.2) Pub Date : 2023-12-08 Matthew Nguyen, Andrea Gutierrez Maria, Fabio R. Faucz, Giampaolo Trivellin, Constantine A. Stratakis, Christina Tatsi
Cushing’s disease (CD) is caused by rare pituitary corticotroph tumors that lead to corticotropin (ACTH) excess. Variants in FAF1, a pro-apoptotic protein involved in FAS-induced cell death, have been implicated in malignant disorders but the involvement of FAF1 in pituitary tumors has not been studied. Genetic data from patients with CD were reviewed for variants in FAF1 gene. Knockout mice (KO) were
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Desmopressin Dose Requirements in Adults with Congenital and Acquired Central Diabetes Insipidus Horm. Metab. Res. (IF 2.2) Pub Date : 2023-12-08 Aslak Nykjær Pedersen, Mikkel Andreassen, Aase Krogh Rasmussen, Jesper Krogh
Central diabetes insipidus is a rare disorder characterized by a deficiency of vasopressin. The first line drug to treat this disorder is a synthetic analogue of vasopressin, desmopressin.The primary aim of this retrospective register study was to compare desmopressin dose requirements in patients with acquired and congenital DI, and secondly to assess the influence of BMI on dose requirement and risk
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Influence of Metabolic Syndrome on the Long-Term Prognosis of Patients with Myocardial Infarction: A Meta-Analysis Horm. Metab. Res. (IF 2.2) Pub Date : 2023-12-06 Tianfeng Chen, Zhewei Shi, Caizhen Qian
The influence of metabolic syndrome (MetS) on long-term prognosis of patients with myocardial infarction (MI), the most severe type of coronary artery disease, remains not fully determined. This systematic review and meta-analysis were conducted to investigate the association between MetS and long-term clinical outcomes of patients with MI. A systematic search of Medline, Web of Science, and Embase
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Bone Mineral Density and Vitamin D Status in Patients with Autoimmune Polyglandular Syndromes: A Single Tertiary Care Center Experience Horm. Metab. Res. (IF 2.2) Pub Date : 2023-12-06
Immunological abnormalities, the resulting endocrinopathies, and their treatments may impact bone health and 25-hydroxyvitamin D (25-OHD) in patients with autoimmune polyglandular syndromes (APS). Several etiologies contribute to increased risk for low bone mineral density (BMD), including vitamin D deficiency. This study evaluated the vitamin D level and BMD of patients with APS. We performed a cross-sectional
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LncRNA H19 Influences Cellular Activities via the miR-454-3p/BHLHE40 Axis in Anaplastic Thyroid Carcinoma Horm. Metab. Res. (IF 2.2) Pub Date : 2023-12-05 Yang Wu, Jihua Yang, Honglai Zhang, Jingjing Cheng, Peijie Lei, Jianyuan Huang
Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy threatening patients’ life quality. Our previous study has demonstrated that inhibition of long non-coding RNA H19 (lncRNA h19; H19) blocks ATC growth and metastasis. The current study aimed to further explore the potential mechanism of H19 in ATC. Expression of H19, miR-454-3p, and BHLHE40 mRNA was measured using RT-qPCR in tissue samples
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DNA Methylation Status of HYAL1 in Malignant and Benign Thyroid Nodules Horm. Metab. Res. (IF 2.2) Pub Date : 2023-12-01 Mengxia Li, Yifei Yin, Minmin Zhang, Chenxia Jiang, Hong Li, Rongxi Yang
Differentiation between benign and malignant thyroid nodules has been a challenge in clinical practice. Exploring a novel biomarker to determine the malignancy of thyroid nodules has important implications. We semi-quantitatively determined the DNA methylation levels of four CpG sites located at the gene body of HYAL1 in formalin-fixed paraffin-embedded (FFPE) tissue samples from 190 early-stage papillary
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Bone Metastases in Patients with Pancreatic NETs: Prevalence and Prognosis Horm. Metab. Res. (IF 2.2) Pub Date : 2023-12-01
The clinical relevance of bone metastases (BM) in advanced pancreatic neuroendocrine tumors (PanNETs) is poorly described. We analyzed 314 consecutive PanNET patients treated at the European Neuroendocrine Tumour Society (ENETS) Center Essen between 2009 and 2021 in terms of the occurrence and clinical and prognostic impact of BM using hybrid imaging with 68Ga-DOTATOC PET/CT. According to UICC staging
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Thyroid Diseases and Intestinal Microbiome Horm. Metab. Res. (IF 2.2) Pub Date : 2023-12-01 Ioannis Legakis, George P. Chrousos, Stylianos Chatzipanagiotou
The human microbiome plays an integral role in health. In particular, it is important for the development, differentiation, and maturation of the immune system, 70% of which resides in the intestinal mucosa. Microbiome studies conducted to date have revealed an association between disturbances in the microbiota (dysbiosis) and various pathological disorders, including changes in host immune status
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The Influence of Hyperglycemia on Liver Triglyceride Deposition in Partially Pancreatectomized Rats Horm. Metab. Res. (IF 2.2) Pub Date : 2023-11-22 Xiu-Ping Bai, Ting-Ting Li, Lai-Li Guo, Jing Wang, Feng Dong
Nonalcoholic fatty liver disease and diabetes always coexist. The relationship of fatty liver and hyperglycemia is not clear. We studied the influence of hyperglycemia on triglyceride (TG) accumulation in the liver and explored its possible mechanisms. SD rats were divided into three groups: Group A (sham operation control), Group B (partially pancreatectomized rats), and Group C (partially pancreatectomized
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Th17 Cell-Related Gene Biomarkers in Osteoporosis: Comprehensive Bioinformatics Analysis and In Vivo Validation Horm. Metab. Res. (IF 2.2) Pub Date : 2023-11-17 Jianxing Chen, Qifeng Sun, Wenzhe Yin
The interaction between the bone and immune systems has a major role in osteoporosis regulation. However, the infiltration of T helper 17 (Th17) cells and their associated genes in osteoporosis remains unclear. The GSE35959 dataset was obtained from the Gene Expression Omnibus (GEO) database, and the Immune Cell Abundance Identifier (ImmuCellAI) program was used to evaluate the abundance of 24 immune
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Mechanistic Insights into Ferroptotic Cell Death in Pancreatic Islets Horm. Metab. Res. (IF 2.2) Pub Date : 2023-11-13 Florian Schepp, Undine Schubert, Janine Schmid, Susann Lehmann, Gladys Oluyemisi Latunde-Dada, Tugba Kose, Charlotte Steenblock, Stefan R. Bornstein, Andreas Linkermann, Barbara Ludwig
Ferroptosis was recently identified as a non-apoptotic, iron-dependent cell death mechanism that is involved in various pathologic conditions. There is first evidence for its significance also in the context of islet isolation and transplantation. Transplantation of pancreatic human islets is a viable treatment strategy for patients with complicated diabetes mellitus type 1 (T1D) that suffer from severe
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LINC00092 Enhances LPP Expression to Repress Thyroid Cancer Development via Sponging miR-542-3p Horm. Metab. Res. (IF 2.2) Pub Date : 2023-11-07 Huan Wang
LINC00092 is poorly expressed in Thyroid cancer (TC), while its role in TC tumorigenesis is still elusive. This study aimed to reveal the role and regulatory mechanism of LINC00092 in TC. RNA immunoprecipitation and dual luciferase reporter assays were employed to ascertain the relationships among lipoma preferred partner (LPP), miR-542-3p, and LINC00092. qRT-PCR analysis was performed to detect their
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Association Between Metabolic Syndrome and the Risk of Lung Cancer: A Meta-Analysis Horm. Metab. Res. (IF 2.2) Pub Date : 2023-11-02 Zhao Zhang, Qinxiang Liu, Congcong Huang, Jun Wu, Yingsheng Wen
Previous studies showed conflicting results regarding the association between metabolic syndrome (MetS) and risk of lung cancer. We performed a systemic review and meta-analysis to determine the relationship between MetS and lung cancer incidence and mortality in adults. Longitudinal follow-up studies were identified by search of Medline, Embase, Cochrane Library, and Web of Science. By incorporating