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Gonadotropin-secreting and thyrotropin-secreting pituitary adenomas: A single-center experience. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-11-17 Manjiri Karlekar,Chakra Diwaker,Vijaya Sarathi,Anurag Lila,Anima Sharma,Saba Samad Memon,Virendra Patil,Tushar Bandgar
Objective Data regarding rare FPAs from India, a resource limited setting, are limited. We describe a case series of rare FPAs from a single center in western India. Materials and methods This was a retrospective case record review of patients diagnosed between January 2010 and July 2022. The diagnosis was based on biochemical(inappropriately elevated serum FSH/LH) and pathologic (positive immunostaining
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Investigation of the molecular genetic causes of non-syndromic primary ovarian ınsufficiency by next generation sequencing analysis. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-11-17 Eren Er,Semih Aşıkovalı,Hatice Özışık,Elif Sağsak,Damla GÖkşen,Hüseyin Onay,Füsun Saygılı,Şükran Darcan,Samim Özen
Objective The aim of this study is to investigate the molecular genetic causes of non-syndromic primary ovarian insufficiency (POI) cases with the gene panel basedon next generation sequencing analysis and to establish the relationship between genotype and phenotype. Materials and methods Twenty three cases aged 14-40 years followed up with POI were included. Patients with a karyotype of 46, XX, primary
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Evaluation of the participation of ABCA1 transporter in epicardial and mediastinal adipose tissue from patients with coronary artery disease. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-11-17 Giovanny Fuentevilla-Álvarez,Claudia Huesca-Gómez,Yazmín Estela Paz-Torres,Nadia González-Moyotl,María Elena Soto,José Antonio García-Valdivia,Reyna Sámano,Martín Martínez-Rosas,Sergio Enrique Meza-Toledo,Ricardo Gamboa
Objective Recent studies have shown a relationship between adipose tissue and coronary artery disease (CAD). The ABCA1 transporter regulates cellular cholesterol content and reverses cholesterol transport. The aim of this study was to determine the relationship between single nucleotide polymorphisms (SNPs) R230C, C-17G, and C-69T and their expression in epicardial and mediastinal adipose tissue in
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The impact of diabetes and subclinical hypothyroidism association with coronary artery calcium: results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-11-17 Aída de Melo Spilack,Alessandra C Goulart,Carolina C P S Janovsky,Bianca de Almeida-Pittito,Paulo A Lotufo,Márcio Sommer Bittencourt,Giuliano Generoso,Itamar de Souza Santos,Isabela M Bensenor
Objective We aimed to analyze the association of diabetes and subclinical hypothyroidism with subclinical atherosclerosis measured by coronary artery calcium (CAC) in the baseline of the ELSA-Brasil study. Materials and methods CAC was measured using a 64-detector computed tomographic scanner. The association of CAC > 0 was presented as an odds ratio (OR) and 95% confidence intervals (95%CI) in logistic
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Assessment of quality of life in patients with craniopharyngioma and identification of risk factors for compromised overall wellness. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-11-17 Ben Lin,Shiyuan Xiang,Jiajun Chen,Yu Jing,Zhao Ye,Yichao Zhang,Xiaoyun Cao,Zhiwen Yin,Nidan Qiao,Xiang Zhou
Objective Quality of Life (QoL) has been a multifactorial concerning issue in oncology. We aimed to inspect the pre-operative QoL among patients with craniopharyngioma and to explore the potential correlations between parameters of QoL and clinical indices. Subjects and methods We enrolled a total of 109 patients with craniopharyngioma. We utilized Short Form 36 (SF-36), Symptom Check List-90, Generalized
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Multiple immunoassay interference in a patient with falsely elevated calcitonin. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-11-17 Mehmet Cagri Unal,Aslihan Cavunt Bayraktar,Tevfik Uslu,Serkan Yener
Calcitonin (CT) is a diagnostic and follow-up marker of medullary thyroid carcinoma. Heterophile antibodies (HAbs) may interfere during immunometric assay measurements and result in falsely high CT levels and different markers. A 50-year-old female patient was referred to our institution for elevated CT levels (3,199 pg/mL [0-11,5]). Physical examination and thyroid ultrasonography show no thyroid
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Germline PRKACA amplification-associated primary pigmented nodular adrenocortical disease: a case report and literature review. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-11-17 Wang-Rong Yang,Xing-Huan Liang,Ying-Fen Qin,Hai-Yan Yang,Shu-Zhan He,Zhen-Xing Huang,Yu-Ping Liu,Zuo-Jie Luo
Primary pigmented nodular adrenocortical disease (PPNAD) is a rare adrenocorticotropin hormone (ACTH)-independent Cushing's syndrome (CS). Pediatric patients with PPNAD typically have unusual skin lesions and slow growth with unknown causes. We present a case of a female Chinese patient with PPNAD caused by the germline PRKACA gene copy number gain of chromosome 19. The patient initially presented
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The effect of anastrozole therapy on final height and sex hormone levels in pubertal boys receiving growth hormone therapy. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-11-17 Gürkan Tarçın,Cansu Koç,Hande Turan,Oya Ercan
Objective This research aimed to evaluate retrospectively the effect of anastrozole on height gain and sex hormone levels in pubertal boys receiving growth hormone (GH). Materials and methods Pubertal boys who received both GH and anastrozole (GH+A) were one-to-one matched with boys who received only GH (GH-Only) for chronological and bone age, pubertal stage and height before the GH initiation, treatment
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Histological findings and NAFLD/NASH Status in liver biopsies of patients subjected to bariatric surgery. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-11-10 Marielle Malucelli,Rodrigo Strobel,Claudia Ivantes,Danielle Sakamoto,Márcio Luís Duarte,Maria Lucia Alves Pedroso
Objective To investigate nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH) and hepatic fibrosis in biopsies of people with obesity who underwent bariatric surgery and examine the possible association of different variables with a diagnosis of NAFLD and NASH. Materials and methods Epidemiological, clinical and laboratory data from 574 individuals with obesity of both genders
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Genetic diagnosis of congenital hypopituitarism in Turkish patients by a target gene panel: novel pathogenic variants in GHRHR, GLI2, LHX4 and POU1F1 genes. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-11-10 Tarık Kırkgöz,Semra Gürsoy,Sezer Acar,Özlem Nalbantoğlu,Beyhan Özkaya,Hüseyin Anıl Korkmaz,Filiz Hazan,Behzat Özkan
Objective Congenital hypopituitarism (CH) is a rare disease characterized by one or more hormone deficiencies of the pituitary gland. To date, many genes have been associated with CH. In this study, we identified the allelic variant spectrum of 11 causative genes in Turkish patients with CH. Materials and methods This study included 47 patients [21 girls (44.6%) and 26 boys (55.4%)] from 45 families
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Use of FGF21 analogs for the treatment of metabolic disorders: a systematic review and meta-analysis. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-11-10 Maria Paula Carbonetti,Fernanda Almeida-Oliveira,David Majerowicz
FGF21 is a hormone produced primarily by the liver with several metabolic functions, such as induction of heat production, control of glucose homeostasis, and regulation of blood lipid levels. Due to these actions, several laboratories have developed FGF21 analogs to treat patients with metabolic disorders such as obesity and diabetes. Here, we performed a systematic review and meta-analysis of randomized
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Long-term consequences of osteoporosis therapy with bisphosphonates. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-11-10 Bárbara Gehrke,Maria Caroline Alves Coelho,Catarina Brasil d'Alva,Miguel Madeira
Bisphosphonates (BPs) are medications widely used in clinical practice to treat osteoporosis and reduce fragility fractures. Its beneficial effects on bone tissue have been consolidated in the literature for the last decades. They have a high affinity for bone hydroxyapatite crystals, and most bisphosphonates remain on the bone surface for a long period of time. Benefits of long-term use of BPs: Large
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Evaluation of the hypothalamo-pituitary-adrenal axis during the post-COVID-19 period in patients treated with steroids during the illness. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-11-10 Shyam Sundar C M,Jayanthy Ramesh
Objective COVID-19 is a multisystem immunoinflammatory disorder, and the hypothalamo-pituitary-adrenal (HPA) axis may be affected by SARS-CoV-2 as well as by steroid treatment during the illness. Information on the HPA axis after recovering from COVID-19, especially in those treated with steroids, is sparse. Hence, this study was performed to evaluate the hypothalamo-pituitary-adrenal axis during the
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Diagnostic value of a computer-assisted diagnosis system for the ultrasound features in thyroid nodules. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-11-10 Yiwei Wang,Ming Yu,Minliang He,Ganjun Zhang,Libo Zhang,Bo Zhang
Objective To explore the diagnostic value of the TUIAS (SW_TH01/II) computer-aided diagnosis (CAD) software system for the ultrasound Thyroid Imaging Reporting and Data System (TI-RADS) features in thyroid nodules. Materials and methods This retrospective study enrolled patients with thyroid nodules in Shanghai East Hospital between January 2017 and October 2021. The novel CAD software (SW_TH01/II)
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Insulin-like growth factor binding protein 3 promoter variant (rs2854744) is associated with nonalcoholic fatty liver disease. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-11-10 Touraj Mahmoudi,Shadi Nouri,Fatemeh Zarei,Zeinab Nourmohammadi Najafabadi,Maryam Sanei,Shiva Sayedsalehi,Gholamreza Rezamand,Asadollah Asadi,Reza Dabiri,Hossein Nobakht,Hamid Farahani,Seidamir Pasha Tabaeian,Mohammad Reza Zali
Objective Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease and a growing global epidemic. In NAFLD, liver fat surpasses 5% of hepatocytes without the secondary causes of lipid accumulation or excessive alcohol consumption. Given the link between NAFLD and insulin resistance, the possible association between the rs2854744 (-202 G>T) promoter polymorphism of insulin-like growth factor
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Genetic polymorphisms in the angiotensin converting enzyme, actinin 3 and paraoxonase 1 genes in women with diabetes and hypertension. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-11-10 Gabrielle Gaspar Arejano,Laura Vargas Hoffmann,Linoska Ferreira Wyse,Poliana Espíndola Correia,Simone Pieniz,Fabiana Torma Botelho,Augusto Schneider,Ines Schadock,Carlos Castilho Barros
Objective To study associations between polymorphisms in the angiotensin converting enzyme (ACE I/D), actinin 3 (ACTN3 R577X) and paraoxonase 1 (PON1 T(-107)C) genes and chronic diseases (diabetes and hypertension) in women. Materials and methods Genomic DNA was extracted from saliva samples of 78 women between 18 and 59 years old used for genetic polymorphism screening. Biochemical data were collected
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A portrait of gestational diabetes mellitus in Brazil: A systematic review and meta-analysis. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-10-18 Betine Pinto Moehlecke Iser,Caroline Stein,Luisia Feichas Alves,Morgana Lourenço de Souza Carvalho,Sergio Angelo Rojas Espinoza,Maria Inês Schmidt
The diagnostic criteria for gestational diabetes mellitus (GDM), a transient hyperglycemic state during pregnancy, has varied remarkably over time, resulting in a diversity of prevalence rates. The aim of this systematic literature review was to provide estimates of prevalence rates of GDM in Brazil according to different diagnostic criteria. We identified, reviewed, and extracted data from the scientific
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Cardiorespiratory fitness in individuals with type 2 diabetes mellitus: a systematic review and meta-analysis. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-09-25 Aline Chagastelles Pinto de Macedo,Camila Wohlgemuth Schaan,Patricia Martins Bock,Mariana Brutto de Pinto,Cintia Ehlers Botton,Daniel Umpierre,Beatriz D Schaan
Objective To conduct a systematic review and meta-analysis assessing the cardiorespiratory fitness (CRF) among individuals with and without type 2 diabetes. Materials and methods The current review was registered in PROSPERO under the number CRD42018082718. MEDLINE, EMBASE, and Cochrane Library databases were searched from inception through February 2022. Eligibility criteria consisted of observational
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Lower 25-hydroxyvitamin D (25OHD) levels, diabetes and age are associated with foot and ankle fracture treatment complications. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-09-25 Hallan Douglas Bertelli,José Luis Braga de Aquino,VÂnia Aparecida Leandro-Merhi
Objective This study investigated the nutritional status, 25-hydroxyvitamin D (25OHD), albumin and risk factors associated with complications in patients with foot and ankle fragility fractures. Subjects and methods Prospective study, developed with patients who suffered fractures due to fragility of the foot and ankle (n = 108); the type of fractured bone, fracture mechanisms and classification were
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"Anti-obesity medications" or "medications to treat obesity" instead of "weight loss drugs" - why language matters - an official statement of the Brazilian Association for the Study of Obesity and Metabolic Syndrome (ABESO) and the Brazilian Society of Endocrinology and Metabolism (SBEM). Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-08-16 Bruno Halpern,Marcio C Mancini,Simone van de Sande-Lee,Paulo Augusto Carvalho Miranda
Obesity is largely undertreated, in part because of the stigma surrounding the disease and its treatment. The use of the term "weight loss drugs" to refer to medications for the treatment of obesity may contribute to this stigma, leading to the idea that anyone who wants to lose weight could use them and that short-term use, only in the active weight loss phase would be enough. On the contrary, the
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References values and predictive factors for thyroid volume in pregnant women. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Lisette Leal Curí,María de Las Mercedes Rubén Quesada,Daysi Antonia Navarro Despaigne,Esther Jequín Savariego,Lisandro Chávez González,Drissa Bina Konaré,Erick Robles Torres
Objective Thyroid volume varies within each population according to different clinical and biochemical factors and can change during pregnancy. The present investigation was aimed to determine the reference values for thyroid volume in pregnant women and their predictive factors. Materials and methods A cross-sectional study was carried out with 360 healthy pregnant women. The following variables were
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Neoadjuvant therapy with anlotinib in a locally advanced and pulmonary metastasis PTC patient harboring TERT promoter and BRAFV600E mutations: a case report. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Yan-Jun Su,Shao-Hao Cheng,Jun Qian,Ming Zhang,Wen Liu,Xiang-Xiang Zhan,Zhu-Quan Wang,Hai-Dan Liu,Xing-Wei Zhong,Ruo-Chuan Cheng
A 71-year-old woman with recurrent papillary thyroid carcinoma (PTC) was referred to our hospital. A computed tomography scan revealed extensive recurrence in the neck, invading sternocleidomastoid muscle, internal jugular vein, sternal end of the clavicle, strap muscle and skin; and lateral compartment and subclavian lymph nodes were also involved. Multiple pulmonary micrometastases also noticed.
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Remission of primary hyperparathyroidism after fine needle aspiration of a parathyroid nodule mistaken for a thyroid nodule. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Eugénia Maria Morado da Silva,Rute Alexandra da Costa Ferreira,Bernardo de Almeida Rodrigues Marques,Martinha Carlota Soares Chorão,João Manuel Sequeira Duarte
Primary hyperparathyroidism (PHPT) is an endocrine disorder characterized by hypercalcaemia and elevated or inappropriately normal concentrations of parathyroid hormone. Remission of PHPT caused by infarction or hemorrhage of a parathyroid adenoma rarely occurs, either spontaneously or induced, not always leading to a definitive cure. We report a case of 72-year-old women with primary hyperparathyroidism
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Immune checkpoint inhibitor-induced endocrinopathies: a possible indicator of improved survival. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Mariana Ornelas,Marta Borges-Canha,Pedro Gouveia,Margarida Ferreira,Eduarda Resende,Maritza Sá,Silvestre Abreu
Objective To evaluate the association between the patients' characteristics and the development of endocrine toxicity and to assess the association between endocrine-related adverse effects (ERAE) development and mortality. Subjects and methods A retrospective observational study was conducted in 98 patients submitted to immunotherapy in our centre since its introduction in 2015 until March 2021. We
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Dietary inflammatory index and its relation to the pathophysiological aspects of obesity: a narrative review. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Roseli Neves de Mello,Bárbara Paixão de Gois,Ana Claudia Pelissari Kravchychyn,Ana Raimunda Dâmaso,Maria Aderuza Horst,Glaucia Carielo Lima,Flávia Campos Corgosinho
Obesity, a complex disease that involves energy imbalance and chronic low-grade inflammation, is implicated in the pathogenesis of several chronic non-communicable diseases. As dietary components modulate the human body's inflammatory status, the Dietary Inflammatory Index (DII®), a literature-derived dietary index, was developed in 2009 to characterize the inflammatory potential of a habitual diet
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Obesity, diabetes, and cancer: epidemiology, pathophysiology, and potential interventions. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Leonardo de Andrade Mesquita,Laura Fink Wayerbacher,Gilberto Schwartsmann,Fernando Gerchman
The proportion of deaths attributable to cancer is rising, and malignant neoplasms have become the leading cause of death in high-income countries. Obesity and diabetes are now recognized as risk factors for several types of malignancies, especially endometrial, colorectal, and postmenopausal breast cancers. Mechanisms implicated include disturbances in lipid-derived hormone secretion, sex steroids
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Coconut oil: an overview of cardiometabolic effects and the public health burden of misinformation. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Bernardo Frison Spiazzi,Ana Cláudia Duarte,Carolina Pires Zingano,Paula Portal Teixeira,Carmen Raya Amazarray,Eduarda Nunes Merello,Laura Fink Wayerbacher,Laura Penso Farenzena,Poliana Espíndola Correia,Marcello Casaccia Bertoluci,Fernando Gerchman,Verônica Colpani
Recent data from meta-analyses of randomized clinical trials (RCTs) suggest that dietary intake of coconut oil, rich in saturated fatty acids, does not result in cardiometabolic benefits, nor in improvements in anthropometric, lipid, glycemic, and subclinical inflammation parameters. Nevertheless, its consumption has surged in recent years all over the world, a phenomenon which can possibly be explained
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Knowledge about diabetes and its association with adherence to self-care and glycemic control in patients with type 1 diabetes in Southern Brazil. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Luciana Foppa,Betina Nemetz,Rosimeri De Matos,Josiane Schneiders,Gabriela Heiden Telo,Beatriz D Schaan
Objective To evaluate the association between knowledge about the disease, adherence to self-care, and glycemic control in people diagnosed with type 1 diabetes mellitus. Subjects and methods A cross-sectional study of patients aged over 18 years diagnosed with type 1 diabetes mellitus, treated at an outpatient clinic of a Brazilian university hospital. Participants with other types of diabetes, cognitive
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Antineoplastic properties of polyphenols in TPC-1 human papillary thyroid carcinoma cell line: a systematic review. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Marielle Lang Makiyama,Maria Júlia Pigatti Degli Esposti,Maria Luíza Raitz Siqueira,Margarete Dulce Bagatini,Sarah Franco Vieira de Oliveira Maciel,Marcelo Moreno
Thyroid cancer usually responds to surgical and ablative therapy, but when it's refractory the alternative lies in tyrosine kinase inhibitors that, in addition to harmful side effects, acts only in a palliative way. The concern for other therapeutic possibilities brought evidence on flavonoids, hypothesizing a possible strategy. This review aimed to organize a compilation of in vitro studies using
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Maternal-fetal outcomes of pregnant women with type 1 diabetes treated with continuous subcutaneous insulin infusion or multiple daily injections during pregnancy - A Brazilian health care referral center cohort study. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Juliana Ogassavara,Patricia Medici Dualib,Rosiane Mattar,Sérgio Atala Dib,Bianca de Almeida-Pititto
Objective Pregnant women with type 1 diabetes (T1D) have an increased risk of maternal-fetal complications. Regarding treatment, continuous subcutaneous insulin infusion (CSII) has advantages compared to multiple daily injections (MDI), but data about the best option during pregnancy are limited. This study's aim was to compare maternal-fetal outcomes among T1D patients treated with CSII or MDI during
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Dietary amino acids and anthropometric indices: Tehran Lipid and Glucose Study. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Farshad Teymoori,Golaleh Asghari,Sanaz Hoseinpour,Sajjad Roosta,Maryam Bordbar,Parvin Mirmiran,Narges Sarbazi,Fereidoun Azizi
Objective Recent studies investigated the role of amino acids (AAs) in weight management. We aimed to determine the association between AAs and three-year change of anthropometric indices and incident obesity. Materials and methods Height, weight, hip, and waist circumference (WC) were collected at baseline and follow up. Three-year changes in anthropometric indices and obesity incident according to
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Risk of malignancy and diagnostic accuracy of fine-needle aspiration biopsy in thyroid nodules with diameters greater than 4 centimeters. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Rafaela N Barcelos,Cléber P Camacho,Maria da Conceição de O C Mamone,Elza S Ikejiri,Felipe A B Vanderlei,Ji H Yang,Rosália P Padovani,Leandro A L Martins,Rosa Paula M Biscolla,Danielle Macellaro,Susan C Lindsey,Rui M B Maciel,João Roberto M Martins
Objective The risk of malignancy and diagnostic accuracy of fine-needle aspiration biopsy (FNAB) of thyroid nodules (TN) with diameters ≥ 3-4 cm remains controversial. However, some groups have indicated surgical treatment in these patients regardless of the FNAB results. We aimed to evaluate the diagnostic accuracy of the FNAB in systematically resected ≥4 cm TN and if the risk of malignancy is higher
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Association between psoriasis and thyroid function: results from the Brazilian Longitudinal Study of Adults Health (ELSA-Brasil). Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Vandrize Meneghini,William R Tebar,Itamar Souza Santos,Carolina Castro Porto Silva Janovsky,Bianca de Almeida-Pititto,Paulo A Lotufo,Alessandra C Goulart,Isabela M Bensenor
Objective To determine the relationship between psoriasis, thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triodothyronine (FT3), thyroid peroxidase antibodies (TPOAb), and subclinical thyroid dysfunctions in middle-aged and older adults. Materials and methods Cross-sectional analyses included a self-reported medical diagnosis of psoriasis and thyroid function from the 3rd visit (2017-2019)
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Treatment of Graves' disease in Brazil: results of a survey among endocrinologists. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Danilo Villagelin,Glaucia M F S Mazeto,Cléo Otaviano Mesa,Helton Estrela Ramos,Rafael Selbach Scheffel,Maria Izabel Chiamolera,Nicolas Perini,Thiago Luis Ronconi,Patricia Texeira
Objective The objective of the study was to determine how physicians in Brazil manage Graves' disease in different scenarios including extrathyroidal manifestations. Materials and methods This study was conducted via a digital survey. The respondents (n = 573) answered multiple-choice questions based on a clinical case and variations of the case regarding laboratory and imaging evaluation, treatment
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Endoscopic endonasal approach for acromegaly: surgical outcomes using 2018 consensus criteria for remission. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Rodrigo Alves de Carvalho Cavalcante,Luiz Alves Vieira,Luís Felipe Araújo Peres,Alice Jardim Zaccariotti,Helioenai de Sousa Alencar,Estela Muszkat Jatene,Leandro Azevedo Camargo,Monike Lourenço Dias Rodrigues
Objective The primary aim is to analyze the endoscopic endonasal surgical results in short-term and two-year follow-ups according to the 11th Acromegaly Consensus statement (2018). Indeed, prognostic factors and complications were analyzed. Subjects and methods 40 patients who underwent endoscopic endonasal surgery by acromegaly between 2013 to 2020 was analyzed. Patients were considered in remission
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Reference intervals for serum TSH concentrations of healthy children from the Central Region of Brazil. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Tula Beatriz Brandão Caldas Meirelles-Cardoso,Natasha Slhessarenko,Cor Jesus Fernandes Fontes
Objective The objective of this study was to determine the serum thyroid-stimulating hormone (TSH) concentration reference intervals (RIs) of healthy children aged 1 to 10 years of both sexes, living in the Central Region of Brazil. Subjects and methods 1,735 children [869 (50.1%) female; 866 (49.9%) male] enrolled in the morning shift of 47 pre- and 83 public elementary schools in the municipality
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Ang-(1-7) attenuates podocyte injury induced by high glucose in vitro. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Jianxin Lu,Guixiang Chen,Guanghui Shen,Wenhao Ouyang
Objective The incidence of diabetic nephropathy (DN) is gradually increasing worldwide. Podocyte injury, such as podocyte apoptosis and loss of the slit diaphragm (SD)-specific markers are early pathogenic features of DN. Materials and methods The cultured mouse podocytes were separated into a high glucose-treated (HG, 30mM) group to mimic DN in vitro, a low glucose-treated (LG, 5mM) group as a control
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Is elevated blood glucose at admission associated with poor outcomes in hospitalized COVID-19 patients? Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-06-19 Mariana Barbosa,Juliana Marques-Sá,Carla Carvalho,Vera Fernandes
Objective Hyperglycemia has been suggested as a risk factor for poor outcomes in coronavirus disease 2019 (COVID-19). The aim of our work was to evaluate the association between blood glucose levels at admission (BGA) and disease outcomes in hospitalized COVID-19 patients. Subjects and methods Retrospective study including all adult COVID-19 patients admitted to a Portuguese hospital from March to
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Association between sitagliptin plus vitamin D3 (VIDPP-4i) use and clinical remission in patients with new-onset type 1 diabetes: a retrospective case-control study. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-25 Marcelo Maia Pinheiro,Felipe Moura Maia Pinheiro,Marcelo Müller de Arruda,Geane Moron Beato,Graciele Alves Corrêa Lima Verde,Georgiana Bianchini,Pedro Rosário Moraes Casalenuovo,Aline Aparecida Agostini Argolo,Lucilene Telles de Souza,Flávia Gomes Pessoa,Thiago Santos Hirose,Eduardo Filgueiras Senra,Camillo Ricordi,Andrea Fabbri,Marco Infante,Susana Nogueira Diniz
Objective The occurrence of partial remission (honeymoon phase) in type 1 diabetes (T1D) has been associated with a reduced risk of chronic microvascular complications of diabetes. We have published case reports showing that a combination therapy with the DPP-4 inhibitor sitagliptin plus vitamin D3 (VIDPP-4i) can prolong the honeymoon phase in patients with new-onset T1D. In the present case-control
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Multimorbidity patterns: obesity as the main modifiable risk factor in adult women in Southern Brazil. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-25 Débora Luiza Franken,Juvenal Soares Dias-da-Costa,Maria Teresa Anselmo Olinto,Jaqueline Sturmer,Rafaela Balzaretti Bordin,Vera Maria Vieira Paniz
Objective To identify multimorbidity patterns in women in southern Brazil, and its relationship with sociodemographic, lifestyle characteristics, and nutritional status, as well as to explore the main independent risk factor for the identified patterns. Subjects and methods This is a cross-sectional, population-based study with 1,128 women (20-69 years), southern Brazil. Chronic conditions were identified
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Patients living with HIV have quantitatively inadequate food consumption. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-25 Bárbara Ferreira Vercesi,Izabela Spereta Moscardini,Gabriel Perri Esteves,Rebeca Antunes Beraldo
Objective The objective of the current study was to estimate energy expenditure and compare it with the usual food consumption of PLWH, and to determine whether duration of high-potency antiretroviral therapy (HAART) influenced nutritional intake and adequacy. Materials and methods Anthropometric measurements and bioelectrical impedance analysis (BIA) provided data for estimating resting energy expenditure
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Association of the serum calcium level with metabolic syndrome and its components among adults in Taiwan. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-25 Jer-Min Chen,Tai-Yin Wu,Yi-Fan Wu,Kuan-Liang Kuo
Objective An increasing amount of literature indicates that the serum calcium level may be related to metabolic syndrome (MetS) and obesity. This study aimed to examine the relationship between the serum calcium level and MetS in adults in Taiwan. Subjects and methods We conducted a crosssectional study and enrolled 1,580 participants (54.4% women; mean age, 33.28 ± 12.21 years) who underwent health
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Dual-energy X-ray absorptiometry and adiposity index are sensitive methods to evaluate central fat accumulation in women with polycystic ovary syndrome and normal body mass index. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-25 Gislaine Satyko Kogure,Victor Barbosa Ribeiro,Maria Célia Mendes,Rui Alberto Ferriani,Cristiana Libardi Miranda Furtado,Rosana Maria Dos Reis
Objective This study aimed to determine the differences in body fat distribution and central obesity indicators using dual-energy X-ray absorptiometry (DXA), adiposity indices, and anthropometric indices between women with and without polycystic ovary syndrome (PCOS). Materials and methods Clinical and laboratory examination history, including transvaginal ultrasound, fasting blood samples, anthropometric
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Pre-exercise meal on oxidation of energy substrates during maximal exercise test in non-trained individuals. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-25 Lucas Ribeiro da Silva,Giuseppe Potrick Stefani,Gilson Pires Dorneles,Aline Marcadenti,Pedro Dal Lago
Objective This study aimed to compare the influence of a high carbohydrate meal versus high-fat meal on the oxidation of substrates during an exercise incremental test. Materials and methods Ten untrained male subjects underwent two days of the protocol. Randomly, they received a high carbohydrate meal or a high-fat meal, receiving the other one in the next protocol. On both days, they performed an
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Sexual dysfunction in women with type 2 diabetes mellitus: A single-centre cross-sectional study from Bangladesh. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-25 A B M Kamrul-Hasan,Muhammad Shah Alam,Nusrat Zarin,Fatema Tuz Zahura Aalpona,Marufa Mustari,Farhana Akter,Nadia Jannat,Umme Azad,Palash Kumar Chanda,Abdur Rafi,Mohammad Jahid Hasan,Shahjada Selim
Objective Sexual dysfunction among women with diabetes is a common but neglected health issue worldwide. The objective of the present study was to investigate the prevalence of sexual dysfunction and its associated factors among women with type 2 diabetes mellitus (T2DM). Subjects and methods This cross-sectional comparative study comprises 150 women with diabetes and 100 healthy women without diabetes
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Ultrasound in cervical traumatic neuromas after neck dissection in thyroid carcinoma patients: descriptive analysis and diagnostic accuracy. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-25 Vinicius Neves Marcos,Debora Lucia Seguro Danilovic,Fernando Linhares Pereira,Miriam Harumi Tsunemi,Marco Aurelio Vamondes Kulcsar,Ana Oliveira Hoff,Regina Barros Domingues,Maria Cristina Chammas,Ricardo Miguel Costa de Freitas
Objective Cervical traumatic neuromas (CTNs) may appear after lateral neck dissection for metastatic thyroid carcinoma. If they are misdiagnosed as metastatic lymph nodes (LNs) in follow-up neck ultrasound (US), unnecessary and uncomfortable fine-needle aspiration biopsy are indicated. The present study aimed to describe US features of CTNs and to assess the US performance in distinguishing CTNs from
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Anthropometric measurements and their association with endothelial function and arterial stiffness of eutrophic individuals and with overweight. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-25 Ariélen Ferigollo,Diego Chemello,Tábata Pereira Pavão,Marco Aurélio Lumertz Saffi,Carolina Dos Santos Stein,Rafael Noal Moresco,Lucas Silva de Souza,Carlos Heitor Cunha Moreira,Luis Ulisses Signori,Patrícia Chagas
Objective The objective of the study was to assess the association of anthropometric measurements with endothelial function and arterial stiffness of eutrophic individuals and with overweight. Subjects and methods A cross-sectional study was carried out with individuals with body mass index (BMI) between 18.5 kg/m2 and < 30 kg/m2, low to intermediate global cardiovascular risk scores, and aged ≥ 18
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Polymorphisms in TIE2 and ANGPT-1 genes are associated with protection against diabetic retinopathy in a Brazilian population. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-25 Cristine Dieter,Natália Emerim Lemos,Nathalia Rodrigues de Faria Corrêa,Taís Silveira Assmann,Felipe Mateus Pellenz,Luís Henrique Canani,Letícia de Almeida Brondani,Andrea Carla Bauer,Daisy Crispim
Objective The objective of this study was to investigate the association between SNPs in the TIE2 and ANGPT-1 genes and diabetic retinopathy (DR). Subjects and methods This study comprised 603 patients with type 2 diabetes mellitus (T2DM) and DR (cases) and 388 patients with T2DM for more than 10 years and without DR (controls). The TIE2 rs639225 (A/G) and rs638203 (A/G) SNPs and the ANGPT-1 rs4324901
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Once-Weekly Insulin Icodec vs. Once-Daily Insulin Glargine U100 for type 2 diabetes: a systematic review and meta-analysis of phase 2 randomized controlled trials. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-25 Rodrigo Ribeiro E Silva,Mateus de Miranda Gauza,Maria Eduarda Schramm Guisso,Júlia Opolski Nunes da Silva,Suely Keiko Kohara
Objective Insulin Icodec is a novel basal insulin analogue designed for once-weekly administration, therefore might propitiate reduction in the frequency of injections and facilitate treatment adherence. This study aimed to determine the glycemic control and safety profile of Insulin Icodec, compared with Glargine U100 in patients with diabetes mellitus type 2. Materials and methods We performed a
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A Brazilian cohort of pregnant women with overt diabetes: analyses of risk factors using a machine learning technique. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-25 Angela J Reichelt,Maria Amélia A de Campos,Vânia N Hirakata,Vanessa K Genro,Maria Lúcia R Oppermann
Objective Pregnancy complicated by type 2 diabetes is rising, while data on type 2 diabetes first diagnosed in pregnancy (overt diabetes) are scarce. We aimed to describe the frequency and characteristics of pregnant women with overt diabetes, compare them to those with known pregestational diabetes, and evaluate the potential predictors for the diagnosis of overt diabetes. Subjects and methods A retrospective
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Similar hypothyroid and sepsis circulating mRNA expression could be useful as a biomarker in onthyroidal illness syndrome: a pilot study. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-25 Robson José de Almeida,Andréa Harumy de Lima Hirata,Luiz Antônio de Jesus Rocha,Miriam Duarte de Arruda Motta,Patricia Varela,Leonardo Martins,João Bosco Pesquero,Cléber P Camacho
Objective Based on hypothetical hypothyroidism and nonthyroidal illness syndrome (NTIS) gene expression similarities, we decided to compare the patterns of expression of both as models of NTIS. The concordant profile between them may enlighten new biomarkers for NTIS challenging scenarios. Materials and methods We used Ion Proton System next-generation sequencing to build the hypothyroidism transcriptome
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Prevalence of metabolic syndrome in adolescents based on three diagnostic definitions: a cross-sectional study. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-25 Dejane de Almeida Melo,Alcione Miranda Dos Santos,Victor Nogueira da Cruz Silveira,Michele Bezerra Silva,Alcides da Silva Diniz
Objective There is no consensus as to the best criterion for the evaluation of metabolic syndrome (MS), impairing the estimation of its prevalence. This study aims to compare MS estimates using three recommended definitions for adolescents based on a cross-sectional study nested in the Consortium of Brazilian Birth Cohorts in São Luís, Maranhão. Subjects and methods A total of 2,515 adolescents aged
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Use of the activPAL® triaxial accelerometer to estimate total energy expenditure in low-income women: differences between body mass index classifications. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-25 Mateus de Lima Macena,Déborah Tenório da Costa Paula,André Eduardo da Silva,Dafiny Rodrigues Silva Praxedes,Karina Pfrimer,Eduardo Ferriolli,Telma Maria de Menezes Toledo Florêncio,Nassib Bezerra Bueno
Objective This study aimed to assess the agreement between the total energy expenditure (TEE) estimated by the activPAL® triaxial accelerometers (ACC) and the TEE measured by the doubly labeled water method (DLW), as well as to assess if these values differ between the classifications of body mass index (BMI). Materials and methods This is a cross-sectional study. Low-income adult women (19-45y) with
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Acute suppurative thyroiditis with Graves disease - A very rare association. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-25 Inês Damásio,Joana Maciel,Maria Manuel Costa,Luisa Raimundo
Acute suppurative thyroiditis is an uncommon disorder caused by a bacterial infection, usually presenting with normal thyroid function. It is a serious condition that requires a prompt diagnosis and treatment with antibiotics and supportive measures. A 62 years-old female presented with a painful cervical induration and odynophagia a week after a fish bone had been removed from her pharynx. She was
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Ghrelin and glucagon-like peptide-1 according to body adiposity and glucose homeostasis. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-12 Karynne Grutter Lopes,Vicente Lopes da Silva,Fernanda de Azevedo Marques Lopes,Eliete Bouskela,Maria das Graças Coelho de Souza,Luiz Guilherme Kraemer-Aguiar
Objective We investigated the biological behavior of ghrelin and glucagon-like peptide-1 (GLP-1) after a standard liquid meal according to body adiposity and glucose homeostasis. Subjects and methods This cross-sectional study included 41 individuals (92.7% women; aged 38.3 ± 7.8 years; BMI 32.2 ± 5.5 kg/m2) allocated into three groups according to body adiposity and glucose homeostasis, as follows:
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Osteonecrosis of the jaws in patients under osteoporosis treatment: a nine-year experience report. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-12 Daniela Cia Penoni,João Vitor S Canellas,Marcos Antonio Nunes Costa Silami,Flávia Sader,Gonçalo Sobreira Pimentel,Anna Thereza Thomé Leão
Objective This study aimed to report the experience of medication-related osteonecrosis of the jaws (MRONJ) in osteoporotic patients for nine years, and their associated initiating factors. Materials and methods The numbers of invasive oral procedures (IOP) (tooth extraction, dental implant placement, and periodontal procedures) and removable prostheses performed from January 2012 to January 2021 were
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Guidelines from the Brazilian society of surgical oncology regarding indications and technical aspects of neck dissection in papillary, follicular, and medullary thyroid cancers. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-12 Terence Farias,Luiz Paulo Kowalski,Fernando Dias,Carlos S Ritta Barreira,José Guilherme Vartanian,Marcos Roberto Tavares,Fernanda Vaisman,Denise Momesso,Alexandre Ferreira Oliveira,Rodrigo Nascimento Pinheiro,Heber Salvador de Castro Ribeiro
Objective The purpose of these guidelines is to provide specific recommendations for the surgical treatment of neck metastases in patients with papillary, follicular, and medullary thyroid carcinomas. Materials and methods Recommendations were developed based on research of scientific articles (preferentially meta-analyses) and guidelines issued by international medical specialty societies. The American
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Maternal prepregnancy obesity and gestational diabetes influence on adverse perinatal outcomes. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-12 Leonardo Souza de Carvalho,Antônia Aparecida Deluca de Oliveira,Tassiana Cristina Martins Grabovski,Carla Christina Renzo,Rodrigo Ribeiro E Silva,Sabrina Hafemann Loz,Jean Carl Silva
Objective Evaluate the influence of isolated and associated prepregnancy obesity and gestational diabetes mellitus (GDM) on adverse perinatal outcomes. Materials and methods Cross-sectional observational study with women who delivered at a Brazilian Maternity Hospital, between August and December 2020. Data were collected by interview with application form, and medical records. Sample was stratified
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Planned parathyroidectomy: the new standard in hypercalcemic crisis. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-12 Murilo Catafesta das Neves,Marcello Rosano,Monique Nakayama Ohe,Giulianno Molina de Mello,Davi Knoll Ribeiro,Rodrigo Oliveira Santos
Objective The study sought to determine the clinical features of hyperparathyroid-induced hypercalcemic crisis (HIHC) along with treatment options and outcomes. Subjects and methods This is a retrospective analysis of our historical cohort of patients with primary hyperparathyroidism (PHPT). Patients were divided in groups according to their calcium levels and clinical presentation. HIHC (group 1)
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Effects of COVID-19 pandemic lockdown on the metabolic control of type 2 diabetes mellitus in patients. Arch. Endocrinol. Metab. (IF 1.7) Pub Date : 2023-05-12 Mehmet Ali Eren,Ataman Gönel,Hüseyin Karaaslan,Nida Uyar,Çiğdem Cindoğlu,Tevfik Sabuncu
Objective The effects of the COVID-19 pandemic on the control of diabetes mellitus in patients are largely unknown. In this study we aimed to analyze the impact of the pandemic and the ensuing lockdown on the management of type 2 diabetes mellitus. Subjects and methods A total of 7,321patients with type 2 diabetes mellitus (4,501 from the pre-pandemic period, 2,820 from the post-pandemic period) were