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Laparoscopic Adrenal Gland Surgery in Times of COVID – Is a Safety-Interval Before Surgery After COVID-Infection Still Mandatory? Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2024-03-08
Background Due to a multicenter study early in the coronavirus disease (COVID)-pandemic that revealed an increased risk for postoperative mortality, thromboembolic and pulmonary complications in case of surgery shortly after a COVID infection, current recommendations for planning elective surgeries suggest postponing surgery for at least 7 weeks after COVID infection. However, virus variants have evolved
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Bilirubin Down-Regulates Oxidative Stress and Fibroblast Growth Factor 23 Expression in UMR106 Osteoblast-Like Cells Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2024-02-19 Steffen Rausch, Katharina Hammerschmidt, Martina Feger, Libor Vítek, Michael Föller
Introduction Fibroblast growth factor 23 (FGF23) is a major regulator of phosphate and vitamin D metabolism in the kidney, and its higher levels in plasma are associated with poorer outcomes in kidney and cardiovascular diseases. It is produced by bone cells upon enhanced oxidative stress and inhibits renal phosphate reabsorption and calcitriol (active form of vitamin D) production. Bilirubin, the
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Perioperative Insulin Pump Therapy Decreases Readmission Risk and Improves Outcomes in Patients with Diabetes Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2024-02-16 Kun Wang, Fang Bai, Xiaopan Chen, Joshua D. Miller, Xue Chen, Chuan Yun, Zhenzhen Sun, Xiaodan Yuan, Qingqing Lou
Objective To evaluate the impact of temporary insulin pump use during hospitalization on glycemia, postoperative complications, and cost/utilization in perioperative patients with diabetes. Methods Patients (n=159) with type 2 diabetes and hospitalized for elective surgery were recruited from three hospitals. Subjects were categorized into the insulin pump group and the multiple daily subcutaneous
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Relationship Between Fasting Blood Glucose and Readmission Within 1 Year in Elderly Patients with Heart Failure Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2024-01-24 Danning Wang, Sumin Wu
Introduction Elevated blood glucose has been linked to unfavorable outcomes among individuals with heart failure (HF). Nevertheless, evidence is scarce regarding the association between fasting blood glucose (FBG) levels and the likelihood of readmission within one year for elderly patients. To address this gap, a retrospective cohort study was conducted, integrating electronic health records of restricted
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Serum Lipid Level in Evaluating Chinese Pancreatic Neuroendocrine Neoplasms: A Retrospective Study Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2024-01-24 Danyang Gu, Bingyan Xue, Guoqin Zhu, Yanling Xu, Lijun Yan, Qiyun Tang, Chun Lu
Background Pancreatic neuroendocrine neoplasms (p-NENs) are relatively rare and highly heterogeneous. Dyslipidemia may be related to the risk of developing p-NENs, although dyslipidemia in patients with p-NENs is rarely reported. In this study, the clinical characteristics of p-NENs patients with different lipid levels and their prognostic value in p-NENs patients were evaluated. Methods Patients (n=211)
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Is There A Connection Between Primary Hypophysitis and Celiac Disease? Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2024-01-18
Aim To investigate the autoimmune and genetic relationship between primary hypophysitis (PH) and celiac disease (CD). Methods The study was retrospective and patients with PH followed in our clinic between 2007 and 2022 were evaluated. Clinical, endocrinologic, pathologic, and radiologic findings and treatment modalities were assessed. Patients diagnosed with CD in the Gastroenterology outpatient clinic
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Novel Association of KLRC4-KLRK1 Gene Polymorphisms with Susceptibility and Progression of Antithyroid Drug-Induced Agranulocytosis Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2024-01-18 Yayi He, Pan Ma, Yuanlin Luo, Xiaojuan Gong, Jiayang Gao, Yuxin Sun, Pu Chen, Suliang Zhang, Yuxin Tian, Bingyin Shi, Bao Zhang
Objective Antithyroid drug (ATD)-induced agranulocytosis (TIA) is the most serious adverse effect during ATD treatment of Graves’ disease (GD). Previously, the MICA gene was reported to be associated with TIA. MICA protein is an important ligand for the NKG2D protein, which is encoded by the KLRK1 gene and KLRC4-KLRK1 read-through transcription. This study further investigated the association between
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Reduction in the Free Androgen Index in Overweight Women After Sixty Days of a Low Glycemic Diet Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2024-01-18 Barbara Zapała, Patrycja Marszalec, Monika Piwowar, Olaf Chmura, Tomasz Milewicz
Background Hyperandrogenism is among the most common endocrine disorders in women. Clinically, it manifests as hirsutism, acne, and alopecia. A healthy lifestyle, including nutritious dietary patterns and physical activity, may influence the clinical manifestation of the disease. This study determined the effect of a low-glycemic index anti-inflammatory diet on testosterone levels and sex hormone-binding
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Impact of Early Diagnostic and Therapeutic Interventions and Clinical Course in Children and Adolescents with Multiple Endocrine Neoplasia Types 1 and 2 Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-12-22 Ja Hye Kim, Yena Lee, Soojin Hwang, Ji-Hee Yoon, Gu-Hwan Kim, Han-Wook Yoo, Jin-Ho Choi
Purpose Multiple endocrine neoplasia types 1 (MEN1) and 2 (MEN2) are inherited endocrine tumor syndromes caused by mutations in the MEN1 or RET genes. This study aimed to investigate clinical outcomes and molecular characteristics among children with MEN. Methods This study included eight patients from seven unrelated families. Data on clinical course, biochemical findings, and radiologic studies were
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Dietary and Nutritional Supplementation for Painful Diabetic Neuropathy: A Narrative Review Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-12-06 Kyriaki Apergi, Nikolaos Papanas
Painful diabetic neuropathy (PDN) is a serious and very common complication of diabetes mellitus (DM). It negatively affects the quality of life, increases morbidity and poses a financial burden on the health care system. Currently, treatment of PDN focuses on glycaemic control, while pathogenesis-oriented therapy has not yielded satisfactory results. The need to improve therapy remains. There is accumulating
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Chloroquine Alleviates Atherosclerosis by Modulating Regulatory T Cells Through the ATM/AMPK/mTOR Signaling Pathway in ApoE −/− Mice Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-12-06 Dan Liu, Yonggang Zhang, Yiyi Zhang, Qiaorong Huang, Wentong Meng, Jinhang Gao, Xianming Mo, Haoming Tian, Sheyu Li
Background Clinical observation suggests the atheroprotective effect of chloroquine and its derivatives, while its mechanism remains unclear. This study aimed to observe the protective effect of chloroquine against atherosclerosis and explore the underlying mechanism. Methods Ataxia telangiectasia mutated (ATM) wild-type or haploinsufficient apolipoprotein-E-knockout (ATM+/+ApoE−/− or ATM+/−ApoE−/−)
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A Comparative Study of Endoderm Differentiation Between Activin A and Small Molecules Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-12-06 Qiang Li, Jin Li, Ping Wang, Xiaoqun He, Mingzhao Hong, Feng Liu
Small molecules such as ROCK inhibitors (Fasudil) and inducer of definitive endoderm 1 (IDE1) can promote differentiation of definitive endoderm, but their effects remain controversial. Therefore, we attempted to verify the effect of these small molecules on promoting definitive endoderm differentiation and found that Fasudil or IDE1 alone could not achieve a similar effect as activin A. On the contrary
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Clinical Significance of T2-Weighted Sequence Intensity on Magnetic Resonance Imaging in Clinically Non-Functioning Pituitary Adenomas Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-12-06 Pedro Iglesias, Betina Biagetti, Marta Araujo-Castro, Victoria Alcázar, Fernando Guerrero-Pérez, Noelia Rivero, Anna Casteràs, Carlos García Gómez, Belén García Izquierdo, Víctor Viedma Torres, Eider Pascual-Corrales, Isabel Pavón, Carles Villabona, Fernando Cordido, Juan J. Díez
Background Little is known about the relationship between signal intensity patterns on T2-weighted magnetic resonance imaging (MRI) in non-functioning pituitary adenomas (NFPAs). Objective In this study, the clinical, hormonal, histological features, and therapeutic responses were evaluated according to the T2 signal intensity in NFPAs. Methods This retrospective and multicenter study included a group
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Male Hypogonadism After Recovery from Acute COVID-19 Infection: A Prospective Observational Study Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-12-04 Aravind Prasad, K. G Rashmi, Jayaprakash Sahoo, Sadishkumar Kamalanathan, Mukta Wyawahare, R Anusuya, Dukhabandhu Naik
Background The severe acute respiratory syndrome coronavirus 2 can affect the hypothalamic-pituitary-gonadal axis (HPG) due to the expression of the angiotensin-converting enzyme 2 receptor. Objectives To assess the prevalence of hypogonadism and Sertoli cell dysfunction in coronavirus disease 2019 (COVID-19) male survivors. Method Male subjects recovered from acute COVID-19 infection were prospectively
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Aerobic Training Increases Hippocampal Volume and Protects Cognitive Function for Type 2 Diabetes Patients with Normal Cognition Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-11-14 Ying Wang, Liping Wang, Juan Yan, Xiaodan Yuan, Qing Q. Lou
Aim To evaluate the effects of aerobic training on hippocampal volume and cognitive function in patients with type 2 diabetes mellitus (T2DM) with normal cognition. Materials and methods One hundred patients with T2DM aged 60–75 years who met inclusion criteria were randomized into the aerobic training group (n=50) and control group (n=50). The aerobic training group received 1 year of aerobic training
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Glycoprotein Non-Metastatic Protein B (GPNMB): The Missing Link Between Lysosomes and Obesity Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-11-13 Valentina Bianco, Dagmar Kratky
As a result of an unhealthy diet and limited physical activity, obesity has become a widespread pandemic worldwide and is an important predictor for the development of cardiovascular disease. Obesity is often characterized by a pro-inflammatory environment in white adipose tissue (WAT), mainly due to increased macrophage infiltration. These immune cells boost their lipid concentrations by accumulating
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Vitamin D Alleviates Type 2 Diabetes Mellitus by Mitigating Oxidative Stress-Induced Pancreatic β-Cell Impairment Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-11-07 Jia Liu, Yuanjun Zhang, Derong Shi, Cuihuan He, Guanghao Xia
Objective Type 2 diabetes mellitus (T2DM) is a common metabolic disorder with rising incidence worldwide. This study explored the anti-T2DM role of vitamin D, thereby providing novel therapeutic strategies. Methods C57BL/6 J mice and MIN6 cells were used to induce in vivo T2DM and damaged β-cell models, respectively. Body weights, fasting blood glucose, and fasting insulin were measured in mice. Oral
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Pioglitazone-Enhanced Brown Fat Whitening Contributes to Weight Gain in Diet-Induced Obese Mice Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-11-03 Piaojian Yu, Wei Wang, Wanrong Guo, Lidan Cheng, Zhiping Wan, Yanglei Cheng, Yunfeng Shen, Fen Xu
Introduction Pioglitazone is an insulin sensitizer used for the treatment of type 2 diabetes mellitus (T2DM) by activating peroxisome proliferator-activated receptor gamma. This study aimed to investigate the effects of pioglitazone on white adipose tissue (WAT) and brown adipose tissue (BAT) in diet-induced obese (DIO) mice. Methods C57BL/6 mice were treated with pioglitazone (30 mg/kg/day) for 4
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Risk-stratified Distant Metastatic Thyroid Cancer with Clinicopathological Factors and BRAF/TERT Promoter Mutations Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-11-03 Xian Cheng, Ying Zhou, Shichen Xu, Huixin Yu, Jing Wu, Jiandong Bao, Li Zhang
Objective To assess the prognostic value of clinicopathological factors as well as BRAF and TERT promoter mutations in predicting distant metastasis in patients with papillary thyroid cancer. Design The status of BRAF and TERTp mutations were available in 1,208 thyroid cancer patients who received thyroidectomy at Jiangyuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine from January 2008
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Investigating the Association Between Diet-Induced “Leaky Gut” and the Development of Prediabetes Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-10-31 Nosipho R. Dimba, Nhlakanipho Mzimela, Palesa Mosili, Phikelelani S. Ngubane, Andile Khathi
Introduction Chronic consumption of a high-calorie diet compromises the gut microbiota and the integrity of the intestinal wall, which causes translocation of bacterial lipopolysaccharides (LPS) into the blood. This elicits the secretion of pro-inflammatory cytokines, resulting in inflammation. However, how a high-fat high carbohydrate diet affects intestinal permeability and its possible role in the
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The Ca2+/Calmodulin-dependent Calcineurin/NFAT Signaling Pathway in the Pathogenesis of Insulin Resistance in Skeletal Muscle Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-10-24 Magdalena Danowska, Marek Strączkowski
Skeletal muscle is the tissue directly involved in insulin-stimulated glucose uptake. Glucose is the primary energy substrate for contracting muscles, and proper metabolism of glucose is essential for health. Contractile activity and the associated Ca2+signaling regulate functional capacity and muscle mass. A high concentration of Ca2+and the presence of calmodulin (CaM) leads to the activation of
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Insulin Glargine is More Suitable Than Exenatide in Preventing Muscle Loss in Non-Obese Type 2 Diabetic Patients with NAFLD Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-10-04 Lin Liu, Ruwen Wang, Jian Gao, Jianhua Yan, Jingtian Zhang, Zhitian Zhang, Jiaojiao Liu, Huandong Lin, Shengxiang Rao, Xiuzhong Yao, Weiyun Wu, Hua Bian, Xiangyu Wang, Shanshan Guo, Xin Gao, Hongmei Yan
Aim This study investigated the effects of insulin glargine and exenatide on the muscle mass of patients with newly diagnosed type 2 diabetes (T2DM) and nonalcoholic fatty liver disease (NAFLD). Methods We performed a post-hoc analysis of our previously study, a 24-week randomized controlled multicenter clinical trial (ClinicalTrials.gov, NCT02303730). Seventy-six patients were randomly assigned 1:1
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Maternal Hyperglycemia Induces Autonomic Dysfunction and Heart Failure in Older Adult Offspring Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-09-27 Odair Alves da Silva, Glória Pinto Duarte, Saad Lahlou
Aims Offspring exposed to an adverse fetal environment, such as gestational diabetes, may manifest increased susceptibility to several chronic diseases later in life. In the present study, the cardiovascular function of three different ages of offspring from diabetic rats was evaluated. Methods and results Diabetes mellitus was induced in pregnant rats by a single dose of streptozotocin (50 mg/kg)
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Association Between Diabetes and Personality Traits Among the Elderly in China: A Latent Class Analysis Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-09-14 Peisheng Xiong, Wanbao Ye, Meijuan Xiong, Kangkang Chen, Kai Xu
Background The present study aimed to identify individuals with different personalities using latent class analysis and further distinguish those with a high risk of diabetes among different clusters. Methods Data were utilized from a large-scale, cross-sectional epidemiological survey conducted in 2018 across 23 provinces in China, employing a multi-stage, stratified sampling technique. Latent class
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Idiopathic Isolated Adrenocorticotropic Hormone Deficiency: A Single-Center Retrospective Study Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-09-08 Chengyan Yang, Xinpei Li, Xiaoqing Ma
Idiopathic isolated adrenocorticotrophic hormone deficiency (IIAD) is rare, with high clinical omission and misdiagnosis rates. This study retrospectively collected information on clinical presentation, laboratory findings, and treatment response of 17 patients with IIAD at Jining No. 1 People's Hospital from January 2014 to December 2022. The clinical characteristics were summarized, and the pertinent
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Transition From Childhood to Adult Care in Patients with Type 1 Diabetes: 20 Years of Experience From the Tübinger Transition Study Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-09-07 Roland Schweizer, Martina Lösch-Binder, Clara Hayn, Silas Friz, Julia Uber, Julian Ziegler, Franziska Liebrich, Andreas Neu
Aims Transition from pediatric to adult care is difficult for patients with chronic diseases. In this study, factors associated with metabolic control in childhood-onset type 1 diabetes (T1D) after transfer to adult care were analyzed. Methods Overall, 224 persons with T1D were contacted yearly from 1998 to 2019. They voluntarily answered a questionnaire about their current hemoglobin A1c (HbA1c) levels
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Potentially Inappropriate Medication Use Among Older Patients with Diabetes in a Chinese Community Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-09-06
Background Potentially inappropriate medications (PIMs) are frequently prescribed to older people with diabetes. This study aimed to assess the prevalence of PIM use in older people with diabetes and identify potential risk factors influencing the development of PIM use. Methods This was a cross-sectional study conducted in an outpatient setting in Beijing, China, using Chinese criteria. The prevalence
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Clinical Characteristics and Long-Term Outcomes of Adrenal Tumors in Children and Adolescents Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-09-06 Ja Hye Kim, Yunha Choi, Soojin Hwang, Ji-Hee Yoon, Gu-Hwan Kim, Han-Wook Yoo, Jin-Ho Choi
Objective Adrenal tumors are generally rare in children and can be a part of familial cancer syndrome. This research was conducted to examine the clinical outcomes, histopathological results, and genetic etiologies of adrenal tumors in children and adolescents. Methods Thirty-one children and adolescents with adrenal tumors were included. Data on clinical outcomes and endocrine and radiologic results
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Stratifying High-Risk Thyroid Nodules Using a Novel Deep Learning System Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-08-21 Chia-Po Fu, Ming-Jen Yu, Yao-Sian Huang, Chiou-Shann Fuh, Ruey-Feng Chang
Introduction The current ultrasound scan classification system for thyroid nodules is time-consuming, labor-intensive, and subjective. Artificial intelligence (AI) has been shown to increase the accuracy of predicting the malignancy rate of thyroid nodules. This study aims to demonstrate the state-of-the-art Swin Transformer to classify thyroid nodules. Materials and Methods Ultrasound images were
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Radiofrequency Ablation in Primary Aldosteronism Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-08-11 Yun-Ni Lee, William Martyn Drake
The radiofrequency ablation (RFA) technique has been extensively used in the treatment of primary malignancies and metastases and has been recently deployed for the treatment of unilateral primary aldosteronism (PA) as an alternative to whole unilateral adrenalectomy. Current evidence comparing RFA with unilateral adrenalectomy in the treatment of PA so far has been variable, with studies being retrospective
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Role of Adrenal Vein Sampling in Guiding Surgical Decision in Primary Aldosteronism Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-08-11 Nada Younes, Stéphanie Larose, Isabelle Bourdeau, Eric Therasse, André Lacroix
Adrenal vein sampling (AVS) is recommended for subtyping primary aldosteronism (PA) to identify lateralized or bilateral sources of aldosterone excess, allowing for better decision-making in regard to medical or surgical management on a case-by-case basis. To date, no consensus exists on protocols to be used during AVS, especially concerning sampling techniques, the timing of sampling, and whether
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Progress in Primary Aldosteronism 7: No better time to meet! Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-08-11 Martin Reincke,William E Rainey,Tracy Ann Williams
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Age at Menarche, Menopause Status and Metabolic Syndrome and its Components: Findings from the Henan Rural Cohort Study Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-08-07 Xueyan Wu, Du Zhen, Xiaotian Liu, Wei Liao, Xiaokang Dong, Jing Yang, Bing Zhao, Chongjian Wang
Introduction To evaluate the effect of age at menarche on metabolic syndrome (Mets) and its components and explore the impact of menopause status on the association between age at menarche and Mets in rural Chinese women. Methods This cross-sectional study enrolled 23382 women from the Henan Rural Cohort study. The relationship between age at menarche and Mets was assessed using logistic regression
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Prospective External Validation of an Algorithm Predicting Hourly Basal Insulin Infusion Rates from Characteristics of Patients with Type 1 Diabetes Treated with Insulin Pumps Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-07-20 Jana S. Schmelzer, Melanie Kahle-Stephan, Juris J. Meier, Michael A. Nauck
Background We previously published an algorithm predicting 24 h basal insulin infusion profiles in insulin pump-treated subjects with type 1 diabetes profiles from six subject characteristics. This algorithm was to be externally validated in an independent environment and patient population. Methods Thirty-two patients with pump-treated type diabetes were switched to their individually algorithm-derived
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Circular RNA circADAM9 Promotes Inflammation, Oxidative Stress, and Fibrosis of Human Mesangial Cells via the Keap1-Nrf2 Pathway in Diabetic Nephropathy Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-07-18 Hongwei Zheng, Xuezheng Liu, Bing Song
Objective Circular RNAs (circRNAs) have been discovered as potential biomarkers for diabetic nephropathy (DN). In this study, the potential roles of circADAM9 in high glucose (HG)-induced cell injury of human mesangial cells (HMCs) were investigated, and the underlying mechanism was elucidated. Methods DN cell model in vitro was simulated by HG treatment of HMCs. Endogenous expressions of circADAM9
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Incidence of Stroke in People With Diabetes Compared to Those Without Diabetes: A Systematic Review Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-07-17 Tatjana Kvitkina, Maria Narres, Heiner Claessen, Maria-Inti Metzendorf, Bernd Richter, Andrea Icks
Background One of the goals of the St. Vincent Declaration was to reduce serious complications of diabetes, including strokes. However, it remains uncertain whether this goal has been achieved. Study aim: To evaluate the incidence of stroke in the diabetic population and its differences regarding sex, ethnicity, age, and region, to compare the incidence rate in people with and without diabetes, and
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Adrenal Vein Sampling in the Young – Necessary or Not? Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-07-17 Eleftheria Gkaniatsa, Oskar Ragnarsson
Current clinical guidelines from the US Endocrine Society state that adrenal venous sampling (AVS) may not be necessary in patients younger than 35 years with marked aldosteronism and a solitary adrenal adenoma on imaging. At the time when the guidelines were published, only one study supported the statement, a study that included 6 patients younger than 35 years, all of whom had unilateral adenoma
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Prevalence of Thyroid Peroxidase and Thyroglobulin Autoantibodies in the Swedish Population Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-06-28 Neele Bergemann, Berglind Jonsdottir, Anna-Lena Nilsson, Mikael Lantz, Alexander Lind
Autoimmune thyroid disease (AITD) may be detected prior to clinical symptoms through the presence of autoantibodies against thyroid peroxidase (TPOab), thyroglobulin (TGab), or both. The present study aimed to develop a novel radiobinding assay (RBA) for TPOab and to determine the prevalence of TPOab and TGab in the Swedish population. Patient samples from 27 newly diagnosed Graves’ disease patients
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Relapsing Syndrome of Inappropriate Antidiuretic Hormone Production Responding to Tolvaptan Treatment in a Patient With a Micronodular Formation of the Posterior Pituitary Gland Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-06-26
The syndrome of inappropriate ADH-secretion (SIADH) is a common cause of low sodium levels with diverse aetiology. Here, we report a case of a 41 years old male patient diagnosed with SIADH and a good response to Tolvaptan therapy. Of interest, as a potential unique cause, magnetic resonance imaging revealed a micronodular structure in the posterior pituitary, while no other common cause of SIADH could
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Combined Training Improves Executive Functions Without Changing Brain-Derived Neurotrophic Factor Levels of Middle-Aged and Older Adults with Type 2 Diabetes Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-06-14 João Gabriel Silveira-Rodrigues, Nathálya Gardênia de Holanda Marinho Nogueira, Larissa Oliveira Faria, Daniele Sirineu Pereira, Danusa Dias Soares
Background Type 2 diabetes mellitus (T2DM) provokes executive function and long-term memory decrements, and aerobic plus resistance training (combined training) may alleviate this T2DM-related cognitive impairment. Brain-derived neurotrophic factor (BDNF) levels have been found to be related to cognitive performance. Aim To analyze the effects of 8-week combined training on executive functions and
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Insulin Secretion Capacity as a Crucial Feature to Distinguish Type 1 From Type 2 Diabetes and to Indicate the Need for Insulin Therapy – A Critical Discussion of the ADA/EASD Consensus Statement on the Management of Type 1 Diabetes in Adults Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-06-12 Andreas Fritsche
In the recently published consensus statement on the treatment and management of type 1 diabetes issued by experts from the American (ADA) and European (EASD) diabetes societies, measurement of endogenous insulin secretion using fasting C-peptide is recommended as a diagnostic criterion. In contrast, our group recently suggested fasting C-peptide/glucose ratio (CGR) for the determination of endogenous
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Serum Periostin Levels are Significantly Higher in Patients with Primary Hyperparathyroidism and Closely Related to Osteoporosis Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-06-05 Ismail Yigitdol, Erdinc Gulumsek, Huseyin Ali Ozturk, Fatih Necip Arici, Kubilay Akbal, Okan Pirinci, Mert Karacay, Tutku Naz Cihan, Zeynep Gizem Totik, Mustafa Aykut Akyildiz, Begum Seyda Avci, Akkan Avci, Hilmi Erdem Sumbul
Background Periostin is an emerging biomarker that plays a role in bone metabolism and may be associated with bone mineral density (BMD). This study is aimed to investigate serum periostin levels in patients with primary hyperparathyroidism (PHPT) and its correlation with BMD in these patients. Methods Forty patients with newly diagnosed PHPT without co-morbidities and 30 healthy controls were included
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Primary Aldosteronism and Drug Resistant Hypertension: A “Chicken-Egg” Story Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-05-31 L Lenzini, G Pintus, G Rossitto, T M Seccia, G P Rossi
Drug-resistant arterial hypertension (RH) is a major risk factor for cardiovascular disease, often due to overlooked underlying causes. Identification of such causes poses significant clinical challenges. In this setting, primary aldosteronism (PA) is a frequent cause of RH and its prevalence in RH patients is likely higher than 20%. The pathophysiological link between PA and the development and maintenance
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Primary Aldosteronism Prevalence – An Unfolding Story Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-05-31 Suranut Charoensri, Adina F. Turcu
Primary aldosteronism (PA) is characterized by dysregulated, renin-independent aldosterone excess. Long perceived as rare, PA has emerged as one of the most common causes of secondary hypertension. Failure to recognize and treat PA results in cardiovascular and renal complications, through processes mediated by both direct target tissue insults and indirectly, by hypertension. PA spans a continuum
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Association of Dietary Niacin Intake with Diabetes in Adults in the United States Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-05-22 Chan Liu, Wenjuan Duan, Wenming Xu
Objective Previous studies have shown inconsistent associations between niacin supplementation and diabetes, and little is known about the relationship between dietary niacin intake and the risk of diabetes in the general population. Our study aimed to explore the association between dietary niacin intake and the risk of diabetes in the adult population in the United States. Methods Data from the 2005–2016
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Association Between Prehospital Blood Glucose Levels and Outcomes in Patients With COVID-19 Infection: A Retrospective Cohort Study Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-05-22 Christophe A. Fehlmann, Laurent Suppan, Christophe Gaudet-Blavignac, Nadia Elia, Karim Gariani
Background Hyperglycaemia is associated with worse outcomes in many settings. However, the association between dysglycaemia and adverse outcomes remains debated in COVID-19 patients. This study determined the association of prehospital blood glucose levels with acute medical unit (intensive care unit or high dependency unit) admission and mortality among COVID-19-infected patients. Methods This was
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Metabolic and Endocrine Complications of Long-COVID-19: A Review Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-05-17 Thushari Bandara, Harshal A Deshmukh, Mohammed Abdalla, Thozhukat Sathyapalan
Over the past two years, the outbreak of coronavirus disease of 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has centralized the interest of the health care systems and the scientific world. The majority of COVID-19-infected individuals recover fully. However, about 12–50% of patients experience various mid- and long-term effects after recovering from the initial
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Digestive, Anorectal, and Urogenital Functions in Patients with Type 2 Diabetes Mellitus, Impaired Glucose Tolerance and Normal Glucose Tolerance: Association with Autonomic Neuropathy Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-05-17 Daniel R Quast, Georgios C Boronikolos, Bjoern A Menge, Thomas GK Breuer, Nina Schenker, Juris J Meier
Aims Gastrointestinal disorders, including constipation and fecal incontinence, are common in type 2 diabetes mellitus (T2DM) and may derive from diabetic autonomic neuropathy, severe intestinal bacterial overgrowth, or a dysfunctional anorectal sphincter. The present study aims to characterize the correlation between these conditions. Methods Patients with T2DM, prediabetes, and normal glucose tolerance
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Fasting Plasma Glucose Levels at the Time of Admission Predict 90-Day Mortality in Patients with Viral Pneumonia. A Prospective Study Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-05-17 Jie Xu, Jianyu Zhao, Liyuan Wu, Xinxin Lu
Purpose To determine the effect of fasting plasma glucose (FPG) level at admission affects the 90-day mortality rate in patients with viral pneumonia. Methods Two hundred fifty viral pneumonia patients were stratified into normal FPG (FPG<7.0 mmol/L), moderately-elevated FPG (FPG=7.0–14.0 mmol/L), and highly-elevated FPG groups (FPG≥14.0 mmol/L) according to the FPG level at the time of admission.
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Effects of Dietary Sodium and Protein Intake on Glomerular Filtration Rate in Subjects with Type 2 Diabetes Treated with Sodium-Glucose Cotransporter 2 Inhibitors Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-05-17 Costanza Gaudio, Marta Seghieri, Chiara Merciai, Claudia Colombi, Giuseppe Spatoliatore, Cristiana Maria Baggiore, Alberto Rosati
Background Approximately one-fourth of patients treated with sodium-glucose cotransporter 2 inhibitors (SGLT2i) experience an acute estimated glomerular filtration rate (eGFR) reduction of more than 10% (“dippers”). High sodium and protein intake can increase intraglomerular pressure and predispose to a decline in renal function. We investigated whether measured creatinine clearance (CrCl) is a sensitive
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Pituitary Surgery in Germany – Findings from the European Pituitary Adenoma Surgery Survey Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-05-12 Malte Ottenhausen, Jens Conrad, Darius Kalasauskas, David Netuka, Florian Ringel
Background Surgery is, next to medical and radiation therapy, the mainstay therapy for pituitary adenomas. While scientific consensus regarding the key aspects of pituitary surgery exists among neurosurgeons, procedures are not standardized and might vary significantly between hospitals and surgeons. Objective To provide an overview of how neurosurgical departments in Germany manage pituitary surgery
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Improving Detection Rates for Primary Aldosteronism Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-05-09 Renata Libianto, Michael Stowasser, Grant Russell, Peter J Fuller, Jun Yang
Primary aldosteronism (PA), once considered a rare disease, is being increasingly recognized as an important cause of hypertension. It is associated with higher rates of cardiovascular complications compared to blood pressure-matched essential hypertension. Targeted treatments are available which can mitigate the excess cardiovascular risks and, in some cases, cure hypertension. Making a timely diagnosis
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An Abbreviated History of Aldosterone Metabolism, Current and Future Challenges Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-05-08 Celso E Gomez-Sanchez, Elise P Gomez-Sanchez
The initial isolation of adrenal steroids from large quantities of animal adrenals resulted in an amorphous fraction resistant to crystallization and identification and had potent effects on electrolyte transport. Aldosterone was eventually isolated and identified in the fraction and was soon shown to cause hypertension when in excess. The autonomous and excessive production of aldosterone, primary
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The Prevalence of Primary Aldosteronism in Screening Populations: Is Hypokalaemia Important? Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-05-09 David M Williams,Ayesha Shaikh,Ellen Williams,Aiman Maroof,Therese Michael,Kusuma Boregowda
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Prediction of Hypoglycemia in Diabetic Patients During Colonoscopy Preparation Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-04-26 Xiaohua Lu, Lingqiao Xie, Wane Zhao, Chuangbiao Zhang, Xixi Luo, Yan Zhou
Objective To explore the clinical outcomes and establish a predictive model of hypoglycemia during colonoscopy preparation for diabetic patients. Methods Three-hundred ninety-four patients with diabetes who received colonoscopy were retrospectively enrolled in this study and assigned to hypoglycemia or non-hypoglycemia groups. Information about clinical characteristics and outcomes during colonoscopy
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Increased Galactosidase Beta 1 Expression as a Senescent Key Factor in β-Cells Function Modulation at the Early Steps of Type 2 Diabetes Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-04-18 Ana T. Maduro, Anabela Pinto, Joana Ferreira-Gomesb, Raquel Costa, Raquel Soares, Carla Luís
Background In type 2 diabetes, insulin resistance is observed, and β-cells are incapable of responding to glycemia demands, leading to hyperglycemia. Although the nature of β-cells dysfunction in this disease is not fully understood, a link between the induction of pancreatic β-cell premature senescence and its metabolic implications has been proposed. This study aimed to understand the relationship
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Effects of Growth Hormone on Muscle and Bone in Female Mice: Role of Follistatin Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-04-13 Takashi Ohira, Naoyuki Kawao, Yoshimasa Takafuji, Yuya Mizukami, Hiroshi Kaji
The interactions between muscle and bone are noted in the clinical relationships between sarcopenia and osteoporosis. Myokines secreted from the skeletal muscles play roles in muscle-bone interactions related to various physiological and pathophysiological states. Although numerous evidence suggests that growth hormone (GH) influences both muscle and bone, the effects of GH on the muscle-bone interactions
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Screening Results for Diabetic Retinopathy in Germany in a Real-world Cohort in a Metropolitan Diabetes Care Center Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-04-13 Bernardo Mertes, Nadine Kuniss, Michael Piorkowski, Linus Paul Mertes, Hans-Peter Hammes
Background Retinal screening is mandatory to prevent vision loss and blindness due to diabetic retinopathy (DR). The aim of the study was to determine retinopathy screening rates and potential barriers in a German metropolitan diabetes care center. Methods Between May and October 2019, 265 patients with diabetes mellitus (95% type 2 diabetes; age 62±13.2 years; diabetes duration 11.1±8.5 years, HbA1c
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Many Faces of Adrenal Lesions in a Large Patient Cohort: What Has Changed Over the Last Two Decades? Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-04-03 Basak Ozgen Saydam, Mustafa Baris, Suleyman Cem Adiyaman, Tevfik Demir, Mehmet Ali Kocdor, Omer Demir, Mustafa Secil, Serkan Yener
Objective To review the presentation characteristics, clinical and hormonal evaluations, and histopathological results of patients with adrenal lesions over a 21-year period and evaluate the changes across the two decades. Methods This single-center, retrospective study included 1003 patients with adrenal lesions who presented to our department between 2000 and 2021. Clinical, metabolic, hormonal,
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Mind the gap: Measured and Calculated Osmolarity are Not Interchangeable in Diabetic Hyperglycemic Emergencies Exp. Clin. Endocrinol. Diabetes (IF 1.8) Pub Date : 2023-04-03 Sebastiaan Paul Blank, Ruth Miriam Blank
Introduction Small case series have reported that diabetic ketoacidosis is associated with an elevated osmolar gap, while no previous studies have assessed the accuracy of calculated osmolarity in the hyperosmolar hyperglycemic state. The aim of this study was to characterize the magnitude of the osmolar gap in these conditions and assess whether this changes over time. Methods In this retrospective