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Metabolically Unhealthy Normal Weight: Prevalence and Associated Factors in an Adult Population from Northwest Colombia Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-18 Julián Andrés López-Herrera, Adriana Nathaly Castillo, Jenny Elizabeth Ordoñez-Betancourth, Wilson de Jesús Martínez Quiroz, Luis Felipe Higuita-Gutiérrez, Milton F Suarez-Ortegon
Background and Aim: Individuals with a normal weight may have metabolic alterations at risk for chronic non-communicable diseases. The prevalence of this condition and associated factors have not been reported in Latin American populations. We aimed to estimate the presence and associated factors of Metabolically Unhealthy Normal Weight (MUNW) in adults from a public program for the control and prevention
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Sex-Based Differences and Risk Factors for Comorbid Nonalcoholic Fatty Liver Disease in Patients with Bipolar Disorder: A Cross-Sectional Retrospective Study [Corrigendum] Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-19 Ying Wang, Yiyi Liu, Xun Zhang, Qing Wu
Corrigendum for the article Sex-Based Differences and Risk Factors for Comorbid Nonalcoholic Fatty Liver Disease in Patients with Bipolar Disorder: A Cross-Sectional Retrospective Study
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A Prediction Model of Preeclampsia in Hyperglycemia Pregnancy Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-18 Yan Fang, Huali Liu, Yuan Li, Ji Cheng, Xia Wang, Bing Shen, Hongbo Chen, Qunhua Wang
Purpose: To investigate the risk factors associated with preeclampsia in hyperglycemic pregnancies and develop a predictive model based on routine pregnancy care. Patients and Methods: The retrospective collection of clinical data was performed on 951 pregnant women with hyperglycemia, including those diagnosed with diabetes in pregnancy (DIP) and gestational diabetes mellitus (GDM), who delivered
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Missed Diagnosis of Gestational Diabetes Mellitus Due to Selective Screening: Evidence from a Cross-Sectional Study in the West Nile Sub-Region, Uganda Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-13 Vincent Abindu, Derick Hope, Mary Aleni, Monicah Andru, Richard Mangwi Ayiasi, Victor Afayo, Caesar Oyet, Ritah Kiconco
Purpose: To ascertain the prevalence and risk factors of gestational diabetes mellitus (GDM) in pregnant women receiving antenatal care (ANC) services within the West Nile subregion of Uganda. Patients and Methods: An analytical cross-sectional study was conducted on 233 pregnant women who are within 24– 28 weeks of gestation and are receiving ANC services in selected hospitals. GDM was diagnosed according
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Assessment of Changes in Body Composition After 3 Months of Dulaglutide Treatment Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-13 Shuqin Chen, Xuepeng Wang, Yong Jin, Xueqin Chen, Qifa Song, Gang Wei, Li Li
Background: Changes in body composition accompanied by glucagon-like peptide 1 receptor agonist (GLP-1RA) induced weight loss have drawn much attention. However, fewer studies have reported body composition changes in patients receiving dulaglutide therapy in Chinese population. Methods: A total of 70 overweight/obese type 2 diabetes mellitus (T2DM) patients who received dulaglutide therapy were included
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Autophagy, Pyroptosis and Ferroptosis are Rising Stars in the Pathogenesis of Diabetic Nephropathy Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-13 Xiudan Li, Lifeng Gao, Xuyang Li, Jingdong Xia, Yurong Pan, Chunying Bai
Abstract: Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes and can potentially develop into end-stage renal disease. Its pathogenesis is complex and not fully understood. Podocytes, glomerular endothelial cells (GECs), glomerular mesangial cells (GMCs) and renal tubular epithelial cells (TECs) play important roles in the normal function of glomerulus and renal
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SIRT3 rs11246020 Polymorphism Associated Postprandial Triglyceride Dysmetabolism Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-12 Liqun Yang, Zhimei Zhang, Yunfeng Zhen, Jing Feng, Jinhu Chen, Guangyao Song
Purpose: Energy metabolism is regulated by SIRT3, no research has been done on the connection between lipid metabolism in the oral fat test and SIRT3 polymorphism. Thus, we conducted a case-control study to investigate the connection between postprandial lipid and SIRT3 polymorphism. Patients and Methods: 402 non-obese Chinese subjects were enrolled and their postprandial lipid response to oral fat
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Quality of Life and Glucose Regulation in Pediatric Patients with Type 1 Diabetes: A Study in the Ningxia Hui Autonomous Region Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-12 Hua Bai, Na He, Yan Zhang, Aqsa Ahmad, Xing-Xing Yang, Yan Ma, Li-Jun Liang
Objective: In this study, we aimed to evaluate the current status of the quality of life (QOL) of pediatric patients and plasma glucose concentration regulation in children with type 1 diabetes (T1DM) in the Ningxia Hui autonomous region. Methods: The study involved children with T1DM admitted to the General Hospital of Ningxia Medical University between October 2011 and October 2021. The children
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Risk Prediction of Diabetes Progression Using Big Data Mining with Multifarious Physical Examination Indicators Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-11 Xiaohong Chen, Shiqi Zhou, Lin Yang, Qianqian Zhong, Hongguang Liu, Yongjian Zhang, Hanyi Yu, Yongjiang Cai
Purpose: The purpose of this study is to explore the independent-influencing factors from normal people to prediabetes and from prediabetes to diabetes and use different prediction models to build diabetes prediction models. Methods: The original data in this retrospective study are collected from the participants who took physical examinations in the Health Management Center of Peking University Shenzhen
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An Update on the Role and Potential Molecules in Relation to Ruminococcus gnavus in Inflammatory Bowel Disease, Obesity and Diabetes Mellitus Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-11 Jinni Hong, Tingting Fu, Weizhen Liu, Yu Du, Junmin Bu, Guojian Wei, Miao Yu, Yanshan Lin, Cunyun Min, Datao Lin
Abstract: Ruminococcus gnavus (R. gnavus) is a gram-positive anaerobe commonly resides in the human gut microbiota. The advent of metagenomics has linked R. gnavus with various diseases, including inflammatory bowel disease (IBD), obesity, and diabetes mellitus (DM), which has become a growing area of investigation. The initial focus of research primarily centered on assessing the abundance of R. gnavus
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Effect of Semaglutide and Empagliflozin on Pulmonary Structure and Proteomics in Obese Mice Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-11 Yu Yang, Xiaoyu Pan, Shuchun Chen
Objective: This study utilized proteomics to investigate changes in protein expression associated with lung health in obese mice exposed to semaglutide and empagliflozin through a high-fat diet. Methods: Twenty-eight male C57BL/6JC mice were randomly assigned to two groups: a control diet group (n = 7) and a high-fat diet group (n = 21). The HFD group was further divided into three groups: HFD group
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Prevalence and Associated Factors of Psychological Distress among Diabetic Patients at Thyolo District Hospital in Malawi: Hospital-Based Cross-Section Study [Response to Letter] Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-09 Gift Kenneth Blangeti, Teddie Chima, Chrispine Nthezemu Kamanga, Esmie Mkwinda
Response to Letter in regards to Prevalence and Associated Factors of Psychological Distress Among Diabetic Patients at Thyolo District Hospital in Malawi: A Hospital-Based Cross-Sectional Study [Letter]
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The Anatomic and Functional Outcomes of Ozurdex-Aided Vitrectomy in Proliferative Diabetic Retinopathy Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-08 Manqiao Wang, Rong Luan, Boshi Liu, Yi Gong, Jinzhi Zhao, Xiteng Chen, Qianhui Yang, Jingjie Liu, Juping Liu, Yan Shao, Xiaorong Li
Purpose: To investigate the 3-months outcomes of patients who underwent intraoperative intravitreal injection of Ozurdex for proliferative diabetic retinopathy (PDR). Methods: This is a prospective randomized controlled clinical trial (ChiCTR2100043399). Seventy-one patients with PDR who had indications for surgery without intravitreal injection history within 3 months preoperatively were enrolled
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Methyl Cinnamate (MC) Alleviates Free Fatty Acids (FFAs) Induced Lipid Accumulation Through the AMPK Pathway in HepG2 Cells Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-07 Yingda Fu, Guangbing Li, Zichen Feng, Jun Liu, Xiaoyu Wang, Tao Wang, Jun Liu
Background: AMP-activated protein kinase (AMPK) plays a critical role in energy metabolism. Its activation leads to the phosphorylation of downstream proteins such as acetyl-CoA carboxylase (ACC) and sterol regulatory element-binding protein-1 (SREBP1), subsequently inhibiting de novo fatty acid synthesis, thereby reducing intracellular triglyceride accumulation. MC is a compound found in extracts
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Development and Validation of a Risk Score for Mild Cognitive Impairment in Individuals with Type 2 Diabetes in China: A Practical Cognitive Prescreening Tool Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-07 Qun Ding, Congcong Yu, Xiang Xu, Yinjiao Hou, Yingwen Miao, Sijue Yang, Shihua Chen, Xuelin Ma, Zhou Zhang, Yan Bi
Aim: Numerous evidence suggests that diabetes increases the risk of cognitive impairment. This study aimed to develop and validate a multivariable risk score model to identify mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus (T2DM). Methods: This cross-sectional study included 1256 inpatients (age: 57.5 ± 11.2 years) with T2DM in a tertiary care hospital in China. MCI was diagnosed
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Evaluation of Statin Indication and Dose Intensification Among Type 2 Diabetic Patients at a Tertiary Hospital Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-07 Pineal Yitbarek Fisseha, Assefa Mulu Baye, Melak Gedamu Beyene, Eyasu Makonnen
Background: Diabetes mellitus (DM) increases cardiovascular disease (CVD) incidence and mortality. While guidelines endorse statin use in type 2 DM (T2DM) to mitigate cardiovascular risks and mortality, challenges like statin initiation and prompt treatment adjustments affect patient outcomes. This study aimed to assess the appropriateness of indications for and dose intensification of statin therapy
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Association Between Dietary Habits and Type 2 Diabetes Mellitus in Thai Adults: A Case-Control Study Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-06 Makhbuba Kalandarova, Ishtiaq Ahmad, Thin Nyein Nyein Aung, Saiyud Moolphate, Yoshihisa Shirayama, Miyoko Okamoto, Myo Nyein Aung, Motoyuki Yuasa
Background: The prevalence of T2DM is escalating in Thailand affecting over 10% of adults aged 20– 79 years old. It is imperative to identify modifiable risk factors that can potentially help mitigate the risk of developing diabetes. Objective: This study aimed to investigate the relationship between dietary habits and type 2 diabetes in Chiang Mai, Thailand. Methods: This case-control study involved
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Drug Safety Evaluation of Sodium-Glucose Cotransporter 2 Inhibitors in Diabetic Comorbid Patients by Review of Systemic Extraglycemic Effects Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-06 Mohammad Belal Omari, Shafiqullah Naseri, Abdul Jalil Hassan
Purpose: The aim of this study is to evaluate the safety of this drug in diabetic patients with comorbidities of all systems. Method: In this review, the beneficial effects of this drug and its mechanism on the disorders of every system of humans in relation to diabetes have been studied, and finally, its adverse effects have also been discussed. The search for relevant information is carried out in
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Association Between Metabolic Dysfunction-Associated Fatty Liver Disease and MACCEs in Patients with Diabetic Foot Ulcers: An Ambispective Longitudinal Cohort Study Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-06 Xiuxian Huang, Zhengming Li, Zhenwei Zhai, Qiu Wang, Rongyan Wei, Jiacheng Mo, Jianhao Huang, Wensheng Lu
Aim: Metabolic dysfunction-related fatty liver disease (MAFLD) is closely related to metabolic disorders. However, the relationship between MAFLD and the prognosis in diabetic foot ulcers (DFUs) remains unclear. This study aimed to explore the association between MAFLD and the risk of major adverse cardiac and cerebral events (MACCEs) in patients with DFUs. Methods: 889 inpatients with DFUs (PEDIS/TEXAS
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Prevalence and Associated Factors of Psychological Distress Among Diabetic Patients at Thyolo District Hospital in Malawi: A Hospital-Based Cross-Sectional Study [Letter] Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-05 Mohamed Jayte
Letter for the article Prevalence and Associated Factors of Psychological Distress Among Diabetic Patients at Thyolo District Hospital in Malawi: A Hospital-Based Cross-Sectional Study
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Predictors of High Cardiovascular Risk Among Nonobese Patients with Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease in a Chinese Population [Letter] Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-05 Quan Lu, Yuanmei Lin, Zhengming Li
Letter for the article Predictors of High Cardiovascular Risk Among Nonobese Patients with Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease in a Chinese Population
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Prevalence and Risk Factors of Diabetes in Patients with Active Pulmonary Tuberculosis: A Cross-Sectional Study in Two Financially Affluent China Cities Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-02 Jing Li, Yanhong Zhao, Youli Jiang, Ying Zhang, Peize Zhang, Lingjun Shen, Zijiao Chen
Background: Tuberculosis (TB) and diabetes mellitus (DM) present a dual burden to public health. The screening of DM in TB patients may aid in the early detection and management of diabetes, ultimately improving treatment outcomes for those with the comorbidity of TB-DM. We aim to examine the prevalence and identify risk factors of diabetes in individuals with active pulmonary tuberculosis (PTB) in
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Assessment of Reference Genes Stability in Cortical Bone of Obese and Diabetic Mice Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-02 Yuanli Ai, Kun Peng, Chunli Li, Jun Zhang, Gang Wang, Bin Wang, Enyi Huang
Introduction: Bone, a pivotal structural organ, is susceptible to disorders with profound health implications. The investigation of gene expression in bone tissue is imperative, particularly within the context of metabolic diseases such as obesity and diabetes that augment the susceptibility to bone fractures. The objective of this study is to identify a set of internal control genes for the analysis
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Association Between Monocyte-to-High-Density Lipoprotein Ratio and Prediabetes: A Cross-Sectional Study in Chinese Population Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-02 Cairong Ruan, Yuchen Li, Zijing Ran, Guodong Liu, Weihao Li, Xinyu Zhang, Shanshan Shao, Yuan Li
Background: The monocyte-to-high-density lipoprotein cholesterol (MHR) ratio has been linked to metabolic disorders. However, there is limited research on the predisposition to MHR and prediabetes. Hence, we conducted a study to investigate the relationship between MHR and the prevalence of prediabetes. Methods: In total, 85,293 participants were included in our cross-sectional observational study
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Body Composition Indicators Jointly Predict Metabolic Unhealthy Phenotypes in Young and Middle-Aged Obese Individuals: A Cross-Sectional Quantitative Computed Tomography Study Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-29 Hao Zhan, Qichun Chen, Tiantian Liu, Yuting Shi, Jinxia Pei, Liwei Zou, Longsheng Wang
Purpose: The main aim of this study is to analyze the relationship between body composition indices and metabolic unhealthy phenotypes in young and middle-aged obese patients and to assess their joint predictive ability. Patients and Methods: A cross-sectional study method was used to select 207 patients who were proposed to undergo weight loss surgery for morbid obesity from March to November 2022
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Development of Serum Lactate Level-Based Nomograms for Predicting Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-03-01 Chunxia Jiang, Xiumei Ma, Jiao Chen, Yan Zeng, Man Guo, Xiaozhen Tan, Yuping Wang, Peng Wang, Pijun Yan, Yi Lei, Yang Long, Betty Yuen Kwan Law, Yong Xu
Purpose: To establish nomograms integrating serum lactate levels and traditional risk factors for predicting diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM) patients. Patients and methods: A total of 570 T2DM patients and 100 healthy subjects were enrolled. T2DM patients were categorized into normal and high lactate groups. Univariate and multivariate logistic regression analyses were
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Health-Related Quality of Life Among Type 2 Diabetes Mellitus Patients Using the 36-Item Short Form Health Survey (SF-36) in Central Ethiopia: A Multicenter Study Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-29 Habtamu Esubalew, Ayele Belachew, Yimer Seid, Habtamu Wondmagegn, Kidus Temesgen, Tsegazeab Ayele
Introduction: Diabetes, one of the major global health emergencies of the 21st century, can affect a patient’s quality of life. A compromised quality of life has adverse effects on self-care practices, resulting in inadequate glycemic control and an increased susceptibility to complications. In Ethiopia, there is a paucity of information regarding the quality of life of patients with type 2 diabetes
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Migraine Duration as a Potential Amplifier of Obesity Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-29 Xi-Xin Fan, Lichao Ye, Ya-Hui Yang, Wen-Jian Huang, Chih-Yuan Ko
Purpose: Migraine is a complex neurovascular disorder with obesity as a notable risk factor. This study aimed to investigate an under-researched area of the association between migraine duration and body composition. Patients and Methods: Patients with migraine from a neurology outpatient department were enrolled and were categorized into four groups based on illness duration: 1 year, 1– 5 years, 5–
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Impaired Sensitivity to Thyroid Hormone and Risk of Carotid Plaque Development in a Chinese Health Check-Up Population: A Large Sample Cross-Sectional Study Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-29 Jiangling Wang, Lijuan Yang, Wei Liu, Chaogang Wei, Junkang Shen
Objective: Previous research on the correlation between thyroid function and carotid plaque has revealed conflicting results, possibly attributable to the sensitivity of thyroid hormone indices. In this study, we aimed to analyze the association between thyroid hormone sensitivity indices and the risk of carotid plaque development in a Chinese health check-up population. Methods: A total of 19,388
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Transcriptomic Analysis of Type 2 Diabetes Mellitus Combined with Lower Extremity Atherosclerotic Occlusive Disease Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-28 Guang Zeng, Yong-Zhi Jin, Yi Huang, Jun-Sheng Hu, Meng-Fan Li, Ming Tian, Jun Lu, Rong Huang
Background: The pathological damage mechanism of type 2 diabetes (T2D) and macroangiopathy is extremely complex, and T2D and arteriosclerosis obliterans have different biological behaviors and clinical features. To explore the mechanism of lower extremity arteriosclerosis occlusion (LEAOD) in T2D patients, we utilized RNA-seq to identify unique gene expression signatures of T2D and LEAOD through transcriptomic
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Alpha-Linolenic Acid Ameliorates Cognitive Impairment and Liver Damage Caused by Obesity Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-28 Xian Zhang, Jialu Bao, Yan Zhang, Xiaodan Wang
Background: Obesity is a growing global problem that causes various complications such as diabetes, cognitive dysfunction, cardiovascular diseases, and hepatobiliary disease. Alpha-linolenic acid (ALA) has been reported to exhibit multiple pharmaceutical effects. This study aimed to explore the effects of ALA on obesity-induced adipose tissue accumulation, cognitive impairment, inflammation, and colonic
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The Relationship Between UA/HDL and Diabetic Peripheral Neuropathy: A Cross-Sectional Analysis Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-27 Ruoxi Zhen, Shuqi Wang, Shuchun Chen
Purpose: This study was designed to analyze correlations between the uric acid to high-density lipoprotein cholesterol ratio (UHR) and peripheral nerve conduction velocity (NCV) among type 2 diabetes mellitus (T2DM) patients. Patients and Methods: This was a single-center cross-sectional analysis of 324 T2DM patients. All patients were separated into a group with normal NCV (NCVN) and a group with
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The Interaction Between Body Mass Index Genetic Risk Score and Dietary Intake on Weight Status: A Systematic Review Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-27 Sara Sokary, Heba Almaghrbi, Hiba Bawadi
Background: The escalating global obesity epidemic and the emergence of personalized medicine strategies point to the pressing need to investigate the interplay between genetic risk scores (GRSs), dietary intake, and their combined impact on weight status. This systematic review synthesizes evidence from diverse studies to elucidate how dietary patterns and individual foods interact with genetic predisposition
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Low Levels of Metrnl are Linked to the Deterioration of Diabetic Kidney Disease Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-27 Jin Chen, Zhi-Yong Li, Fei Xu, Chao-Qun Wang, Wen-Wen Li, Jin Lu, Chao-Yu Miao
Objective: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Metrnl is a secreted protein that plays an important role in kidney disease. The aim of this study was to investigate DKD-related factors and the correlation between serum Metrnl levels and the severity of DKD. Methods: Ninety-six type 2 diabetes mellitus (T2DM) patients and 45 DKD patients were included in the
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Gender Differences in the Incidence of Nephropathy and Changes in Renal Function in Patients with Type 2 Diabetes Mellitus: A Retrospective Cohort Study Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-26 Fan Zhang, Yan Han, Guojun Zheng, Wenjian Li
Purpose: This research aims to examine and scrutinize gender variations in the incidence of diabetic nephropathy (DN) and the trajectory of renal function in type 2 diabetes mellitus (T2DM) patients. Patients and Methods: We conducted a retrospective cohort study that enrolled 1549 patients diagnosed with T2DM from May 2015 to July 2023. We separately compared the clinical characteristics of male and
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TG: A Mediator of the Relationship of Serum Uric Acid to Creatinine Ratio and Nonalcoholic Fatty Liver Disease in Non-Obese Patients with Type 2 Diabetes Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-27 Qing Wang, Ke Liu, Tian Zhang, Ting Wang, Huan Li, Chang Wang, Jinhu Chen, Luping Ren
Background: The study estimated the association between NAFLD and SUA/Cr in Chinese non-obese patients with type 2 diabetes mellitus (T2DM) and also investigated mediating effect of TG. Methods: All patients were divided into NAFLD group (n = 420) and non-NAFLD group (n = 347). The differences of biochemical indicators between the two groups were compared. The link between SUA/Cr and other parameters
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The Expression of miR-377-3p in Patients with DKD and the Regulatory Mechanism of miR-377-3p on the Inflammatory Response of HK-2 Cells Through TGF-β Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-23 Chenhao Xing, Yamin Lu, Guangxia Liu, Fang Chen, Zhan Hou, Yiwen Zhang
Objective: The purpose of the study was to investigate the expression levels and correlation of inflammatory factors such as miR-377-3p and TGF-β in patients with diabetic kidney disease (DKD), and to investigate the regulatory mechanism of transfection of miR-377-3p on the inflammatory response of HK-2 cell induced by high glucose. Methods: According to UACR, patients were divided into normal albuminuria
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Evaluation of miRNA Expression in Patients with Gestational Diabetes Mellitus: Investigating Diagnostic Potential and Clinical Implications Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-23 Mateusz Kunysz, Marek Cieśla, Dorota Darmochwał-Kolarz
Purpose: Gestational diabetes mellitus (GDM) is common pregnancy complication (8%), characterized by hyperglycemia resulting from pathological homeostatic mechanisms. There’s a concerning trend of increasing GDM prevalence. New markers, particularly epigenetic ones, are sought for early detection and enhanced care. miRNA are small non-coding RNA molecules. The main goal was to investigate the potential
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Prevalence and Associated Factors of Psychological Distress Among Diabetic Patients at Thyolo District Hospital in Malawi: A Hospital-Based Cross-Sectional Study Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-22 Gift Kenneth Blangeti, Teddie Chima, Chrispine Nthezemu Kamanga, Esmie Mkwinda
Background: Emotional distress experienced by individuals with diabetes represents a type of psychological strain specific to the challenges posed by diabetes. It mirrors the emotional reactions arising from coping with the demands of the illness and the essential care associated with diabetes. The study aimed to determine the prevalence and associated factors of psychological distress among diabetic
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Effects of Glucagon-Like Peptide-1 Receptor Agonists on Gut Microbiota in Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome Mice: Compared Evaluation of Liraglutide and Semaglutide Intervention Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-21 Chuanhao Xiong, Jingzhu Wu, Yuhang Ma, Na Li, Xuejiao Wang, Yao Li, Xiaoying Ding
Purpose: Polycystic ovary syndrome (PCOS) is a frequent cause of infertility in reproductive-age women. Our work aims to evaluate the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on gut microbiota, with metabolic parameters including body weight and the hormone profile in PCOS. Patients and Methods: Dehydroepiandrosterone (DHEA)-induced PCOS mice were established and then treated
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PRE1BRAZIL Protocol: A Randomized Controlled Trial to Evaluate the Effectiveness and Safety of the DPP-4 Inhibitor Alogliptin in Delaying the Progression of Stage 2 Type 1 Diabetes Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-21 Jaquellyne Gurgel Penaforte-Saboia, Carlos Eduardo Barra Couri, Natasha Vasconcelos Albuquerque, Lana Livia Peixoto Linard, Daniel Autran Cavalcante Araújo, Sherida Karanini Paz de Oliveira, Thisciane Ferreira Pinto Gomes, Marcelo Maia Pinheiro, Maria Helane Costa Gurgel Castelo, Virgínia Oliveira Fernandes, Renan Magalhães Montenegro Júnior
Background: The incidence of Type 1 Diabetes Mellitus (T1DM) is on the rise. Since there is no curative treatment, it is urgent to look for therapies that can delay disease progression and protect pancreatic β-cells. Dipeptidyl peptidase-4 inhibitors (DPP-4i) have shown potential in modulating inflammation and preventing β-cell destruction. This protocol describes an upcoming trial to evaluate the
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IFN-γ, SCF, MIP1b and IL-16 Were Associated with Risk of Diabetic Nephropathy: A Mendelian Randomization Study Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-22 Li An, Xiaomei Ren, Ye Pan, Wei Gao, Liqun Ren, Jing Wang, Yao Wang
Background: The impact of inflammatory factors on the risk of diabetic nephropathy (DN) is inconsistent. Two-sample Mendelian randomization (MR) analyses were used to detect the causal role of inflammatory factors in DN risk. Methods: Inflammatory factor GWAS summary data were collected from a meta-analysis including 8,293 Finnish participants, and DN information was extracted from a GWAS of 213,746
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Prevalence and Risk Factors of Non-Alcoholic Fatty Liver Disease (NAFLD) in Non-Obese Patients with Schizophrenia: A Retrospective Study Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-20 Wenying Yi, Haibo Wu, Weibin Fu, Huimei Feng, Jie Huang, Haijing Li, Zhen Song, Yuwei Chen, Yingjun Zheng, Shenglin She
Background: To assess the prevalence and risk factors of NAFLD in non-obese patients with schizophrenia in a public psychiatric hospital in China. Methods: A total of 1,305 adult inpatients with schizophrenia in 2019 were included in this retrospective study. Body mass index (BMI) ≥ 25 kg/m2 was considered obese, and BMI < 25 kg/m2 was considered non-obese. We obtained the data from electronic records
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Strong Association of Metabolic Parameters with ADMA and VCAM-1 in Normo-Weight Subjects with Metabolic Syndrome Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-19 Iis Inayati Rakhmat, Gaga Irawan Nugraha, Eko Fuji Ariyanto, Yuni Susanti Pratiwi, Desy Linasari, Siti Nur Fatimah, Mohammad Ghozali, Mas Rizky AA Syamsunarno, Mohammad Rizki Akbar, Tri Hanggono Achmad
Background: Metabolic syndrome (MetS) is a risk factor for cardiovascular disease and is linked to obesity. Subjects with MetS who have normo-weight potentially show higher mortality and morbidity. Purpose: This study aims to reveal the critical essential metabolic parameters associated with endothelial dysfunction in MetS subjects with normo-weight compared to obese. Patients and Methods: The study
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The Burden of Dyslipidemia and Determinant Factors Among Type 2 Diabetes Mellitus Patients at Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-16 Berhanu Kelemework, Kindie Woubshet, Sinetibeb Amsalu Tadesse, Betelhem Eshetu, Dereje Geleta, Worku Ketema
Background: Diabetes is a global health challenge with escalating prevalence rates. Cardiovascular complications represent the leading cause of mortality among individuals with diabetes. Notably, dyslipidemia stands as a prominent risk factor for cardiovascular disease in Type 2 diabetes mellitus (T2DM) patients. Timely detection and management of dyslipidemia in these patients hold the potential to
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Diabetes Mellitus and Thyroid Cancers: Risky Correlation, Underlying Mechanisms and Clinical Prevention Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-16 Rongqian Wu, Junping Zhang, Guilin Zou, Shanshan Li, Jinying Wang, Xiaoxinlei Li, Jixiong Xu
Abstract: The incidences of thyroid cancer and diabetes are rapidly increasing worldwide. The relationship between thyroid cancer and diabetes is a popular topic in medicine. Increasing evidence has shown that diabetes increases the risk of thyroid cancer to a certain extent. This mechanism may be related to genetic factors, abnormal thyroid-stimulating hormone secretion, oxidative stress injury, hyperinsulinemia
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Investigation of Monogenic Diabetes Genes in Thai Children with Autoantibody Negative Diabetes Requiring Insulin Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-14 Nipaporn Teerawattanapong, Thanida Tangjarusritaratorn, Tassanee Narkdontri, Jeerunda Santiprabhob, Watip Tangjittipokin
Purpose: The objective of this study was to clarify the phenotypic characteristics of monogenic diabetes abnormalities in Thai children with autoantibody-negative insulin. Patients and Methods: Two hundred and thirty-one Thai type 1 diabetes (T1D) patients out of 300 participants with recent-onset diabetes were analyzed for GAD65 and IA2 pancreatic autoantibodies. A total of 30 individuals with T1D
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Association of Hematological Parameters and Diabetic Neuropathy: A Retrospective Study Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-13 Aysha A AlShareef, Moafaq S Alrawaili, Salwa Awwadh Almutairi, Mustafa Mohammad Ayyad, Weam Alshora
Background: Diabetic neuropathy (DN) is a common complication of type 2 diabetes (T2DM) and is characterized by persistent inflammation. Hematological parameters have emerged as a novel marker for detecting chronic inflammatory conditions, including diabetes. Aim: We aim to examine the association between HbA1c levels, which can indicate the presence of diabetic neuropathy, and hematological parameters
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The Impact of Obesity on the Host–Pathogen Interaction with Influenza Viruses – Novel Insights: Narrative Review Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-13 Victor Daniel Miron, Anca Cristina Drăgănescu, Daniela Pițigoi, Victoria Aramă, Adrian Streinu-Cercel, Oana Săndulescu
Abstract: After exposure to a viral pathogen, the host–pathogen interaction is essential to determine whether or not infection will ensue, and what the clinical outline of the infection will be. Recent research has shown that the patient with obesity presents a set of particular pathophysiological changes that lead to higher severity of viral infections, and this is particularly true for infection
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Determinants of Overweight Among Type Two Diabetes Mellitus Patients Attending Public Hospitals At Awusi Resu Zone of Afar Region: Unmatched Case–Control Study Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-13 Huzeyfa Kassaw, Kedir Hussein, Abel Gebre, Anwar Ali Seid, Mohammed Ammie
Background: Diabetes is a major cause of morbidity and mortality; affecting More than 415 million people. Objective: The primary aim of this study was to assess the determinants of being overweight among Type 2 Diabetic patients attending diabetic clinics of public Hospitals in the Awusi resu zone of Afar region, Northeast Ethiopia. Methods: A hospital-based unmatched case–control study design was
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Network Pharmacology, Molecular Docking, and Experimental Verification to Reveal the Mitophagy-Associated Mechanism of Tangshen Formula in the Treatment of Diabetic Nephropathy Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-13 Yinfeng Chen, Xiaying Wang, Jie Min, Jie Zheng, Xuanli Tang, Xiaoling Zhu, Dongrong Yu, De Jin
Purpose: This study investigated the mechanism of TSF in treating DN through network pharmacology, molecular docking, and experimental validation. Methods: To identify critical active ingredients, targets, and DN genes in TSF, multiple databases were utilized for screening purposes. The drug-compound-target network was constructed using Cytoscape 3.9.1 software for network topological analysis. The
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Prevalence of Diabetes and Associated Factors Among Government Employees of Mizan-Aman Town and Zonal Sector Office, Bench Sheko Zone, Southwest Ethiopia Region, 2022 Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-12 Mesfin Yimam Zegeye, Tewodros Yosef, Abyot Asres
Introduction: Diabetes mellitus (DM) is a serious non-communicable disease (NCD) that represents a major health and development challenge of the 21st century. Ethiopia is the leading country among the top five high-burden African countries for the number of people with diabetes. To address problems within the population, it is important to assess the prevalence of diabetes and identify the risk factors
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ZJU Index as a Predictive Tool for Diabetes Incidence: Insights from a Population-Based Cohort Study Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-12 Chenjiao Wu, Yi Hao Loh, Hangkai Huang, Chengfu Xu
Background: In previous studies, the ZJU index was reported to be a superior predictor of nonalcoholic fatty liver disease in the Chinese population compared to the Fatty Liver Index. However, whether the ZJU Index is significantly associated with diabetes among Asian populations has not been determined. Methods: The NAGALA study was carried out at Murakami Memorial Hospital (Gifu, Japan) beginning
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The Effect of Tirzepatide on Weight, Lipid Metabolism and Blood Pressure in Overweight/Obese Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-12 Xiaoyu Lv, Hui Wang, Chongyang Chen, Yangting Zhao, Kai Li, Yawen Wang, Liting Wang, Songbo Fu, Jingfang Liu
Aim: To explore the effects of Tirzepatide (TZP), a new hypoglycemic drug, on weight, blood lipids and blood pressure in overweight/obese patients with type 2 diabetes mellitus (T2DM). Methods: Relevant studies investigating the influence of TZP therapy on weight, lipid profiles and blood pressure in overweight/obese T2DM patients were selected from the PubMed, Embase, Web of Science and Cochrane databases
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Assessment of Quality of Diabetic Care in Teaching Hospitals in Ethiopia: In Comparison to International Guidelines Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-09 Mengesh Akale, Tirhas Tadesse, Balew Arega
Background: Comprehensive high quality of care is critical in preventing diabetic complications and improving quality of life. This needs compliance with guidelines and focused therapy. There is no data in Ethiopia evaluating the quality of diabetes care using standard guidelines (American diabetic association and international diabetic federation) as a reference. Methods: A cross-sectional study was
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Taurine Regulates the Expression of Interleukin −17/10 and Intestinal Flora and Protects the Liver and Intestinal Mucosa in a Nonalcoholic Fatty Liver Disease Rat Model Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-09 Fu-Li Zhu, Ting Huang, Zi-Li Lv, Gang Liang, Zhen Yao, Lian-Cheng Lan, Abdul Qadir, Xiu-Qi Chen, Qing-Wen Shan
Purpose: To investigate the intestinal inflammatory response and the abundance of intestinal bacteria in rats with high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) and assess the intervention effects of taurine (TAU). Methods: Forty male Sprague-Dawley rats were randomly divided into five groups: group I, normal diet and normal saline gavage; group II, normal diet and TAU gavage;
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Uric Acid Metabolic Disorders in Pituitary-Target Gland Axis Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-07 Ru Li, Baofeng Wu, Minmin Han, Mengnan Li, Xifeng Yang, Jian Zhang, Yi Zhang, Yunfeng Liu
Abstract: Uric acid (UA) is the end product of purine metabolism in the human, and the imbalance between production and excretion results in the disturbance of serum uric acid (SUA). There is evidence suggesting that pituitary-target gland hormones can affect UA metabolism through regulating the activity of xanthine oxidase and UA transporters. Related endocrine diseases including thyroid dysfunction
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Fecal Microbiota Transplantation: A Prospective Treatment for Type 2 Diabetes Mellitus Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-08 Xiaolan Zhou, Rumeng Chen, Yichen Cai, Qiu Chen
Purpose of Review: The aim of this review is to summarize the role of gastrointestinal microbiome (GM) in the development of type 2 diabetes mellitus (T2DM). Besides, we discuss the feasibility of applying FMT in the treatment of T2DM and propose a series of processes to refine the use of FMT in the treatment of T2DM. Recent Findings: T2DM is a metabolic disease which is connected with the GM. According
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The Association of Hematological Parameters in Early and Middle Pregnancy with the Risk of Gestational Diabetes Mellitus Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-07 Yanbei Duo, Shuoning Song, Xiaolin Qiao, Yuemei Zhang, Jiyu Xu, Jing Zhang, Zhenyao Peng, Yan Chen, Xiaorui Nie, Qiujin Sun, Xianchun Yang, Ailing Wang, Wei Sun, Yong Fu, Yingyue Dong, Zechun Lu, Tao Yuan, Weigang Zhao
Objective: Gestational diabetes mellitus (GDM) is a condition of glucose intolerance, which may be accompanied with inflammation. The levels of hematological parameters during pregnancy can reflect inflammatory conditions in pregnant women. This study aims to describe the dynamic change of blood cell parameters from the first trimester (6– 12 weeks of gestation) to the second trimester (24– 28 weeks
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Evaluation of Red Blood Cell Indices for Prediction of Glycemic Control in People Living with Type 2 Diabetes Diabetes Metab. Syndr. Obes. Targets Ther. (IF 3.3) Pub Date : 2024-02-07 Meiraf Daniel Meshesha, Ayantu Melke, Abraham Teka Ajema, Kaleb Mayisso
Background: Achieving target glycemic control in people living with diabetes lessens most of the diabetes-related complications and hemoglobin A1C is the gold standard test for assessing the long-term glycemic control. However, the expensive cost, and its limited access are problematic for routine use in developing countries, demanding an urgent alternative solution. Hence, this study aimed to assess