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PKM2 is a Novel Osteoporosis-Associated Protein in Chinese Endocr. Res. (IF 2.1) Pub Date : 2024-01-30 Qing Xu, Chun-Hui Li, Chang-Hua Tang, Xiao-Li Huang, Long-Fei Wu, Xu Zhou, Shu-Feng Lei, Fei-Yan Deng
Purpose:Osteoporosis is characterized by low bone mineral density (BMD) and high risk of osteoporotic fracture (OF). Peripheral blood monocytes (PBM) can differentiate into o...
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Advances in Thyroid Organoids Research and Applications Endocr. Res. (IF 2.1) Pub Date : 2024-01-13 Kaiyu Song, Yaqi Wang, Yuantao Wang, Wenjie Yao, Yuxiao Tang, Xinghan Tian, Xicheng Song, Jin Zhou
Organoids are three-dimensional cellular aggregates derived from stem cells or primary tissues that can self-organize into organotypic structures and showcase the physiological functions of that or...
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Sex-Specific Variations in the mRNA Levels of Candidate Genes in Peripheral Blood Mononuclear Cells from Patients with Diabetes: A Multistep Study Endocr. Res. (IF 2.1) Pub Date : 2024-01-04 Yuzhen Cen, Dana Feng, Rasoul Kowsar, Zhen Cheng, Yu Luo, Qingyu Xiao
Type 2 diabetes (T2D) is one of the most prevalent diseases that also show sexual dimorphism in many different aspects.This study aimed to distinguish the mRNA expression of genes in peripheral blo...
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Animal Models of Type 2 Diabetes Complications: A Review Endocr. Res. (IF 2.1) Pub Date : 2024-01-04 Zhongyan Sun, Yadi Liu, Yonghua Zhao, Youhua Xu
Diabetes mellitus is a multifactorial metabolic disease, of which type 2 diabetes (T2D) is one of the most common. The complications of diabetes are far more harmful than diabetes itself. Type 2 di...
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Differential Gene Expression Analysis of Human Ovarian Follicular Cumulus and Mural Granulosa Cells Under the Influence of Insulin in IVF Ovulatory Women and Polycystic Ovary Syndrome Patients Through Network Analysis Endocr. Res. (IF 2.1) Pub Date : 2024-01-04 Pankaj Pant, Havagiray Chitme, Reema Sircar, Ritu Prasad, Hari Om Prasad
Polycystic ovarian syndrome (PCOS) is a commonly occurring reproductive disorder among the reproductive-aged women. Its global occurrence varies based on diagnostic guidelines, ethnicities, and loc...
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Retraction Endocr. Res. (IF 2.1) Pub Date : 2024-01-04
Published in Endocrine Research (Vol. 49, No. 1, 2024)
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Antibodies Reactive to Leptin in Adults with Type 2 Diabetes and Its Relationship with Clinical, Metabolic and Cardiovascular Risk Parameters Endocr. Res. (IF 2.1) Pub Date : 2024-01-04 Ana B. Vargas-Antillón, Mildren Porchas-Quijada, Eloy A. Zepeda-Carrillo, Rafael Torres-Valadez, José F. Muñoz-Valle, Rafael Vázquez-Solórzano, Elia Valdés-Miramontes, Luis A. Hernández-Palma, Zyanya Reyes-Castillo
Patients with obesity and type 2 diabetes (T2D) have shown alterations in the affinity of IgG anti-leptin antibodies which are possibly related to metabolic alterations. In the present exploratory ...
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Sex Differences in the Association Between AST/ALT and Incidence of Type 2 Diabetes in Japanese Patients with Nonalcoholic Fatty Liver Disease: A Retrospective Cohort Study Endocr. Res. (IF 2.1) Pub Date : 2024-01-04 Cong Zhang, Qian Xu, Chengye Xu, Kun Yang, Tian Xia, Wuying Hasi, Ming Hao, Hongyu Kuang
The purpose of the current study was to investigate the association between Aspartate Transaminase (AST)/Alanine transaminase(ALT) and type 2 diabetes (T2DM) in nonalcoholic fatty liver disease (NA...
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The Impact of Glucocorticoid Treatment on Hypocalcemia Following Thyroid Surgery: A Systematic Review and Meta-Analysis Endocr. Res. (IF 2.1) Pub Date : 2023-12-11 Xiao Gang Zheng, Ming Zheng Wang, Fan Wang, Dan He
Patients undergoing thyroidectomy often develop hypocalcemia. While there is evidence suggesting that the prophylactic administration of dexamethasone in patients undergoing thyroidectomy can reduc...
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Serum Follistatin Levels are Independently Associated with Exercise Tolerance in Patients with Obesity Endocr. Res. (IF 2.1) Pub Date : 2023-09-05 Satoshi Kurose, Katsuko Onishi, Takumi Miyauchi, Kazuhisa Takahashi, Yutaka Kimura
Follistatin (FST)/myostatin (MST) myokine-signaling axis is important for muscle metabolism and pathogenesis of obesity. FST, mainly secreted by skeletal muscle and liver, inhibits MST and affects ...
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Ultrasonic Feature Prediction of Large-Number Central Lymph Node Metastasis in Clinically Node-Negative Solitary Papillary Thyroid Carcinoma Endocr. Res. (IF 2.1) Pub Date : 2023-08-22 Weihan Xiao, Xiaomin Hu, Chaoxue Zhang, Xiachuan Qin
The purpose of this study was to investigate the preoperative prediction of large-number central lymph node metastasis (CLNM) in single thyroid papillary carcinoma (PTC) with negative clinical lymp...
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Hyperandrogenism Protects Against High Blood Pressure by Nongenomic Mechanisms and Obesity Causes Hypertension in Females with Polycystic Ovary Syndrome Endocr. Res. (IF 2.1) Pub Date : 2023-08-20 Mercedes Perusquía, Nieves Herrera, Jaime Jasso-Kamel, Lorena González, Nohemí Alejandre
Androgens induce vasorelaxation and reduce blood pressure in different mammals, including humans. Most women with polycystic ovary syndrome (PCOS), with hyperandrogenism, are obese and exhibit hype...
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Assessment of Triglyceride–Glucose Index and Ratio in Patients with Type 2 Diabetes and Their Relation to Microvascular Complications Endocr. Res. (IF 2.1) Pub Date : 2023-08-11 Heba S. Kassab, Nermin A. Osman, Shimaa M. Elrahmany
Triglyceride-based indices have gained much attention over the past few years. Relation of triglyceride – glucose (TyG) index with insulin resistance and diabetic macrovascular complications was th...
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Hypothalamic-Pituitary Adrenal Axis Status 3 Months After Recovery From COVID-19 Infection Endocr. Res. (IF 2.1) Pub Date : 2023-08-11 Rashmi K G, Nandhini Perumal, Anusha Cherian, Mukta Wyawahare, Aravind Prasad, Jayaprakash Sahoo, Sadish Kumar Kamalanathan, Anusuya R, Dukhabandhu Naik
Coronavirus disease 2019 (COVID-19) predominantly involves the lungs, albeit many other organ systems, including the hypothalamic-pituitary-adrenal (HPA) axis, can be affected due to the expression...
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Gender variations in the impact of hyperuricemia on thyroid disorders Endocr. Res. (IF 2.1) Pub Date : 2023-06-29 Qiang Wang, Xixuan Lu, Li Xu, Haiyan Liang
This study aimed to examine the impact of hyperuricemia on various thyroid disorders with emphasized focus on differences resulting from different genders. 16094 adults aged ≥18 years were enrolled...
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T Cell Subsets are Associated with Clinical Activity and Efficacy of 4.5g Intravenous Glucocorticoid for Moderate-To-Severe Thyroid-Associated Ophthalmopathy Endocr. Res. (IF 2.1) Pub Date : 2023-06-22 Huixia Li, Bin Wang, Qin Li, Qing Li, Jie Qiao, Dongping Lin, Chunhua Sui, Lin Ye, Hualing Zhai, Boren Jiang, Ningjian Wang, Bing Han, Mengda Jiang, Xiaofeng Tao, Ziyang Shao, Chenfang Zhu, Yubo Ma, Ping Xiong, Jing Sun, Huifang Zhou, Yingli Lu
ABSTRACT Background Intravenous glucocorticoid (IVGC) remains the main treatment for moderate-to-severe and active thyroid-associated ophthalmopathy (TAO). However, a substantial number (20–30%) of active moderate-to-severe TAO patients may not respond to IVGC. Some patients may have disease progression despite IVGC treatment or relapse after steroid withdrawal. Objectives To analyze risk factors for
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The Association Between Hypothyroidism Treatment and Mortality in Patients Hospitalized in Surgical Wards Endocr. Res. (IF 2.1) Pub Date : 2023-05-31 Hiba Masri-Iraqi, Yaron Rudman, Carmel Friedrich Dubinchik, Idit Dotan, Talia Diker-Cohen, Liat Sasson, Tzipora Shochat, Ilan Shimon, Eyal Robenshtok, Amit Akirov
ABSTRACT Limited data are available regarding the association between pre-admission thyroid-stimulating hormone (TSH) levels and prognosis in hospitalized surgical patients treated for hypothyroidism. We retrospectively evaluated a cohort of 1,451 levothyroxine-treated patients, hospitalized to general surgery wards. The 30-day mortality risk was 2-fold higher for patients with TSH of 5.0–10.0 mIU/L
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The Spectrum of Thyroid Function Tests and Autoantibodies During Hospitalization and After Six Months of Discharge in COVID-19 Patients: Does COVID-19 Trigger Autoimmunity? Endocr. Res. (IF 2.1) Pub Date : 2023-03-08 Ziynet Alphan Uc, Pinar Yagcı, Zelal Adibelli, Cevdet Duran
ABSTRACT Objective The aim of the study was to investigate thyroid function test (TFT) results and anti-thyroid antibody titers in acutely infected COVID-19 patients, as well as the changes in TFT and autoantibody results during the 6-months recovery period among survivors. Patients and Design A total of 163 adult COVID-19 patients and 124 COVID-19 survivors were evaluated in terms of TFT (thyroid
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Relationship Between Appetite-Related Peptides and Frailty in Older Adults Endocr. Res. (IF 2.1) Pub Date : 2023-02-17 Burcu Candemir, İbrahim İleri, Mehmet Muhittin Yalçın, Aydın Tuncer Sel, Berna Göker, Özlem Gülbahar, İlhan Yetkin
ABSTRACT Background Frailty, is a geriatric syndrome that reduces the resistance to stress situations caused by activities of daily living and increases morbidity and mortality. We hypothesized that a decrease in orexigenic peptides or an increase in anorexigenic peptides might be associated with frailty. We aimed to investigate the relationship between frailty and six appetite-related peptides: ghrelin
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Sensitivity of Different ACTH and Cortisol Concentration Values in Corticotropin-Releasing Hormone Based Tests in Cushing’s Disease Endocr. Res. (IF 2.1) Pub Date : 2023-02-13 Shehrban Sobeh Khalil, Mohammad Sheikh Ahmad, Talia Sarah-Hefer, Ekaterina Yovanovich, Maria Reut, Limor Chen-Konak, Nariman Saba-Khazen, Leonard Saiegh
ABSTRACT Purpose In Cushing’s disease (CD) patients, the aim of the present study is to confirm sensitivity of several ACTH and cortisol concentration values in different time points, during corticotropin-releasing hormone (CRH) stimulation test and during CRH stimulation following dexamethasone suppression (DEX-CRH) test. Methods We retrospectively analyzed cortisol and ACTH concentration increment
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Pre- and Post-treatment Serum BAFF Levels and BAFF Gene Polymorphisms in Patients with Graves’ Disease Endocr. Res. (IF 2.1) Pub Date : 2023-01-13 Tarak Dhaouadi, Imen Rojbi, Sameh Ghammouki, Ibtissem Ben Nacef, Meriem Adel, Sabrine Mekni, Karima Khiari, Taïeb Ben Abdallah, Imen Sfar, Yousr Gorgi
ABSTRACT Background B cell activating factor (BAFF), a crucial factor for B cell survival and differentiation, has been linked to several autoimmune conditions. The aim of this study was to evaluate the association of BAFF gene’s polymorphisms with its serum levels and to assess their effect on Graves’ disease (GD) susceptibility and presentation. Methods Sixty-two GD patients and 152 healthy controls
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Evaluation of Adrenal Reserve in Patients with Differentiated Thyroid Cancer Receiving Thyroid Hormone Suppression Therapy- case-control Comparative Study Endocr. Res. (IF 2.1) Pub Date : 2022-12-16 Muhammet Cuneyt Bilginer, Abbas Ali Tam, Sevgul Faki, Nagihan Bestepe, Fatma Dilek Dellal, Didem Ozdemir, Oya Topaloglu, Reyhan Ersoy, Bekir Cakir
ABSTRACT Background Patients with differentiated thyroid cancer (DTC) are exposed to subclinical exogenous hyperthyroidism for the suppression of thyroid-stimulating hormone (TSH). In this study, we aimed to evaluate the adrenal reserve in DTC patients receiving suppression therapy. Materials and Methods The study included 55 DTC patients on suppression therapy and 32 healthy volunteers. Basal serum
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Gender Difference in the Association of Hyperuricemia with Insulin Resistance and beta-cell Function in Nondiabetic Korean Adults: The 2019 Korea National Health and Nutrition Examination Survey Endocr. Res. (IF 2.1) Pub Date : 2022-11-02 Jeong Min Seong, Mi Young Gi, Ju Ae Cha, Hyun Ho Sung, so Young Park, Cho Hee Park, Hyun Yoon
ABSTRACT Aims This study was conducted to assess the association of uric acid (UA) with the homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-B) by gender in nondiabetic Korean adults. Materials and Methods The study was carried out using data from the 2019 Korean National Health and Nutrition Examination Survey and included nondiabetic Korean men, premenopausal
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Platelet–Lymphocyte Ratio, Neutrophil–Lymphocyte Ratio and Their Dynamic Changes with Type 2 Diabetes Mellitus: A Cohort Study in China Endocr. Res. (IF 2.1) Pub Date : 2022-09-26 Canjia Zhang, Huan Chen, Shangxin Cui, Yeli Lin, Yongqiang Liang, Ping Zhao, Changyi Wang, Shan Xu, Xiaolin Peng, Hongen Chen, Li Wang, Dan Zhao, Ming Zhang, Dongsheng Hu, Yanmei Lou, Fulan Hu
ABSTRACT Background This study aimed at investigating the relationships between Platelet-Lymphocyte ratio (PLR) and Neutrophil–Lymphocyte ratio (NLR) and their dynamic changes (∆PLR, ∆NLR) with type 2 diabetes mellitus (T2DM) in a Chinese cohort study. Methods This study recruited 41,439 individuals who were diagnosed without T2DM at first health examination and completed at least one follow-up. The
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Association between the Extent of Peripheral Blood DNA Methylation of HIF3A and Accumulation of Adiposity in community-dwelling Women: The Yakumo Study Endocr. Res. (IF 2.1) Pub Date : 2022-09-14 Genki Mizuno, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Yoshitaka Ando, Ryosuke Fujii, Yoshiki Tsuboi, Atsushi Teshigawara, Itsuki Kageyama, Keisuke Osakabe, Keiko Sugimoto, Hiroaki Ishikawa, Naohiro Ichino, Yoshiji Ohta, Koji Ohashi, Shuji Hashimoto, Koji Suzuki
ABSTRACT Introduction DNA methylation in the CpG sites of intron 1 of HIF3A is associated with body mass index (BMI). This cross-sectional study investigated correlations between DNA methylation of HIF3A and BMI or adiposity parameters in the Japanese population. Method DNA methylation of HIF3A was quantified via pyrosequencing. Result DNA methylation of HIF3A differed only in women; DNA methylation
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Robert I. Gregerman, MD (1930–2021). An Editorial Reminiscence Endocr. Res. (IF 2.1) Pub Date : 2022-09-13 Michael S. Katz, Paul J. Davis
Published in Endocrine Research (Vol. 47, No. 3-4, 2022)
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Hyperuricemia is Associated with the Presence of Metabolically Obese Normal-Weight and Metabolically Healthy Obese Phenotypes Endocr. Res. (IF 2.1) Pub Date : 2022-08-02 Fernando Guerrero-Romero, Luis E. Simental-Mendía
ABSTRACT Background It is well-recognized that hyperuricemia is a common abnormality among individuals with metabolic syndrome. Aims The objective of this study was to determine whether hyperuricemia is associated with the metabolically obese normal-weight (MONW) and metabolically healthy obese (MHO) phenotypes. Methods Men and women equal or greater than 18 years of age were enrolled in a cross-sectional
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Morphometric and Myelin Basic Protein Expression Changes in Arcuate Nucleus Kisspeptin Neurons Underlie Activation of Hypothalamic Pituitary Gonadal-axis in Monkeys (Macaca Mulatta) during the Breeding Season Endocr. Res. (IF 2.1) Pub Date : 2022-07-22 Hira Zubair, Shazia Shamas, Hamid Ullah, Ghulam Nabi, Tanzeel Huma, Rahim Ullah, Rashad Hussain, Muhammad Shahab
ABSTRACT Introduction Kisspeptin is involved in the hypothalamic pituitary gonadal-axis’ seasonal regulation in rodents and sheep. Studies of kisspeptin signaling in regulating the transition between breeding and nonbreeding seasons have focused on kisspeptin expression, myelin basic protein (MBP) expression around kisspeptin-ir cells, and quantifying the synaptic connections between kisspeptin and
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Are We Only Detecting the Tip of the Iceberg? A Nationwide Study on Primary Aldosteronism with up to 8-Year Follow-up Endocr. Res. (IF 2.1) Pub Date : 2022-04-29 Hrafnhildur Gunnarsdottir, Gudbjorg Jonsdottir, Gudjon Birgisson, Jon Gudmundsson, Helga Agusta Sigurjonsdottir
ABSTRACT Background Long-term follow-up studies on primary aldosteronism (PA) are lacking. Objective We aim to review results of diagnostic procedures and histopathology for patients diagnosed during 2012–2016 in Iceland, compare unilateral (UD) and bilateral disease (BD) and assess treatment response. Methods Thirty-two patients aged 28–88 were diagnosed and treated according to guidelines. Results
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The Triglycerides and Glucose Index Is Associated with Mild Cognitive Impairment in Older Adults Endocr. Res. (IF 2.1) Pub Date : 2022-04-08 Yéssika Weyman-Vela, Luis E. Simental-Mendía, Abelardo Camacho-Luis, Claudia I. Gamboa-Gómez, Fernando Guerrero-Romero
ABSTRACT Background It has been reported that insulin resistance is related to cognitive decline. The triglycerides and glucose (TyG) index, is a reliable and inexpensive surrogate test for detecting insulin resistance. Aims The goal of this study was to evaluate the association between the TyG index and the mild cognitive impairment (MCI) in older adults. Methods A total of 135 individuals, men and
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The Relationship between the Lipid Accumulation Product and Beta-cell Function in Korean Adults with or without Type 2 Diabetes Mellitus: The 2015 Korea National Health and Nutrition Examination Survey Endocr. Res. (IF 2.1) Pub Date : 2022-03-18 Hye Eun Cho, Seung Bum Yang, Mi Young Gi, Ju Ae Cha, so Young Park, Hyun Yoon
ABSTRACT Aims This study was conducted to assess the relationship between the lipid accumulation product index (LAP) and the homeostasis model assessment for insulin resistance (HOMA-IR) and beta-cell function (HOMA-B) in Korean adults with or without type 2 diabetes mellitus (T2DM). Materials and Methods The study was carried out using data from the 2015 Korean National Health and Nutrition Examination
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The Association of RGS2 and Slug in the Androgen-induced Acquisition of Mesenchymal Features of Breast MDA-MB-453 Cancer Cells Endocr. Res. (IF 2.1) Pub Date : 2022-02-16 Dana B. Alsafadi, Mohammad S. Abdullah, Randa Bawadi, Mamoun Ahram
ABSTRACT Background Epithelial-mesenchymal transition (EMT) of tumor cells is a prerequisite to cancer cell invasion and metastasis. This process involves a network of molecular alterations. Androgen receptor (AR) plays an important role in the biology of breast cancers, particularly those dependent on AR expression like luminal AR (LAR) breast cancer subtype. We have recently reported that the AR
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Oocyte Survival and Development during Follicle Formation and Folliculogenesis in Mice Lacking Aromatase Endocr. Res. (IF 2.1) Pub Date : 2021-12-04 Jessica M. Toothaker, Kristen Roosa, Alexandra Voss, Suzanne M. Getman, Melissa E. Pepling
ABSTRACT Background Assembly of oocytes into primordial follicles is essential for establishing the ovarian reserve required for female fertility. In mice, this process begins during embryonic development. Primordial germ cells form cysts by incomplete mitosis until 13.5 days post coitum (dpc). These cysts break apart just before birth. Some oocytes undergo apoptosis while surviving oocytes are enclosed
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Association between Circulating Adiponectin and Heart Rate Recovery in Women with Polycystic Ovarian Syndrome Endocr. Res. (IF 2.1) Pub Date : 2021-12-04 Wenjiang Sun, Guanghui Liu, Bin Liu
ABSTRACT Context Adiponectin (APN) is reported to be correlated closely with autonomic nervous function in different clinical settings. Heart rate recovery (HRR) is a noninvasive and readily obtainable indicator, which reflects the coordinated interplay between parasympathetic reactivation and sympathetic withdrawal. Objective This study aimed to investigate the relationship between serum APN and HRR
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Possible Contributions of Nongenomic Actions of Thyroid Hormones to the Vasculopathic Complex of COVID-19 Infection Endocr. Res. (IF 2.1) Pub Date : 2021-11-14 Paul J. Davis, Hung-Yun Lin, Aleck Hercbergs, Kelly A. Keating, Shaker A. Mousa
ABSTRACT Background Integrin αvβ3 is a cell membrane structural protein whose extracellular domain contains a receptor for L-thyroxine (T4). The integrin is expressed in rapidly dividing cells and its internalization is prompted by T4. The protein binds viruses and we have raised the possibility elsewhere that action of free T4 (FT4)—when he latter is increased in the nonthyroidal illness syndrome
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Differential Risk of Cancer Associated with Glucagon-like Peptide-1 Receptor Agonists: Analysis of Real-world Databases Endocr. Res. (IF 2.1) Pub Date : 2021-08-30 Jiasheng Wang, Chang H. Kim
ABSTRACT Background Glucagon-like peptide 1 receptor agonists (GLP1Ra) are commonly used in type 2 diabetes mellitus (T2DM). However, differential risk of various cancers among GLP1Ra recipients is unknown. Methods We inquired an aggregated electronic health record database, Explorys, and compared the adjusted odds ratio (aOR) of cancers between GLP1Ra and metformin users. Findings were validated in
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The Relationship Between Insulin Use And Increased Mortality In Patients With COVID-19 And Diabetes: A Meta-Analysis Endocr. Res. (IF 2.1) Pub Date : 2021-08-19 Wanteng Wang, Yu Sun, Shuai Wang, Yunbo Sun
ABSTRACT Purpose: The purpose of this study is to review observational studies on the effect of insulin use and mortality in patients with COVID-19 and diabetes. Methods: A systematic literature search was performed using the PubMed, Medline, EMBASE, and Cochrane Library databases. The meta-analysis was performed using a random effects model, and I2 was applied to evaluate heterogeneity. Sensitivity
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Serologic Testing for Celiac Disease in Graves’ Hyperthyroidism: Should We Act Early? Endocr. Res. (IF 2.1) Pub Date : 2021-08-10 Hande Demirdere, Ozge Telci Caklili, Sema Yarman
ABSTRACT Background The general practice is to screen patients with autoimmune thyroid disease for celiac disease (CD); however, optimal timing for CD screening for patients with Graves’Disease (GD) has not been identified yet. The aim of the study was to show whether positive celiac antibodies persist after euthyroidism is achieved. Materials and Methods Serum samples were collected from 35 patients
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Sarcopenia is Associated with Reduced Survival following Surgery for Adrenocortical Carcinoma Endocr. Res. (IF 2.1) Pub Date : 2021-08-03 Mechteld C de Jong, Neel Patel, Zaki Hassan-Smith, Radu Mihai, Shahab Khan
ABSTRACT Aim Adrenocortical cancer (ACC) is an aggressive malignancy and robust prognostic factors remain unclear. The presence of sarcopenia has been shown to negatively impact survival for other malignancies, but has not been extensively analyzed in ACC. Methods Patients who underwent resection of their ACC between 2010 and 2020 were identified; therapeutic, operative, and outcome data were analyzed
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Post-treatment heterogeneity of cardiometabolic risk in patients with acromegaly: The impact of GH and IGF-1 Endocr. Res. (IF 2.1) Pub Date : 2021-06-09 Mahshid Heydari, Nahid Hashemi-Madani, Zahra Emami, Alireza Khajavi, Mohammad Ghorbani, Mojtaba Malek, Manizhe Ataei Kachuee, Mohammad E. Khamseh
ABSTRACT Background Metabolic abnormalities are frequently seen in patients with acromegaly. However, it is not clear to what extent growth hormone/insulin-like growth factor-1 (GH/IGF-1) contributes to the development of these abnormalities. Objective This study aimed to explore the impact of postoperative GH/IGF–1 on different aspects of metabolic abnormalities in patients with acromegaly. Methods
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The Ratios of Triglycerides and C-reactive protein to High density-lipoprotein -cholesterol as valid biochemical markers of the Nascent Metabolic Syndrome Endocr. Res. (IF 2.1) Pub Date : 2021-06-03 Ishwarlal Jialal, Beverley Adams-Huet
ABSTRACT Aims: Metabolic syndrome (MetS), a cardiometabolic cluster, is a major global problem. The ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) is a good biomarker of MetS in certain populations C-reactive protein (CRP) has also been also shown to be a biomarker of MetS. Since CRP captures inflammation, we compared the ratios of TG to HDL-C and CRP to HDL-C in patients
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AST-120 Treatment Alters the Gut Microbiota Composition and Suppresses Hepatic Triglyceride Levels in Obese Mice Endocr. Res. (IF 2.1) Pub Date : 2021-06-01 Yuki Hiraga, Tetsuya Kubota, Makoto Katoh, Yasushi Horai, Hiroyuki Suzuki, Yusuke Yamashita, Rieko Hirata, Masao Moroi
ABSTRACT Background: The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing worldwide. The existence of a relationship between the microbiota and the pathology of hepatic steatosis is also becoming increasingly clear. AST-120, an oral spherical carbon adsorbent, has been shown to be useful for delaying dialysis initiation and improving uremic symptoms in patients with chronic
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Women with Subclinical Hypothyroidism are at Higher Prevalence of Metabolic Syndrome and Its Components Compared to Men in an Older Chinese Population Endocr. Res. (IF 2.1) Pub Date : 2021-05-24 Ling Deng, Lin Wang, Xiaoxia Zheng, Ping Shuai, Yuping Liu
ABSTRACT Purpose: This study investigated the impact of sex differences on the relationship of subclinical hypothyroidism (SCH) with the prevalence of metabolic syndrome (MetS) and its components in an older Chinese population. Methods: The study included 1842 older Chinese individuals aged 65 years or older who received annual health checkups. The impact of sex differences on the relationship of SCH
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Meta-Analysis of Randomized Controlled Trials Comparing the Efficacy of Radioactive Iodine Monotherapy versus Radioactive Iodine Therapy and Adjunctive Lithium for the Treatment of Hyperthyroidism Endocr. Res. (IF 2.1) Pub Date : 2021-05-24 Fahad Wali Ahmed, Omar Zuhair Kirresh, Muhammad Shakeel Majeed, Mawara Iftikhar, Muhammad Shafique Sajid
ABSTRACT Background: The objective of this article is to evaluate the outcomes in patients undergoing radioactive iodine (RAI) with adjunctive lithium (Li) therapy versus (vs.) RAI therapy alone for the treatment of hyperthyroidism. Methods: A systematic review of the literature was undertaken to analyze clinical trials comparing RAI with adjunctive Li therapy vs. RAI therapy alone for the treatment
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Association between Thyroid Function and Prognosis of COVID-19: A Retrospective Observational Study Endocr. Res. (IF 2.1) Pub Date : 2021-05-20 Shan Lang, Ye Liu, Xue Qu, Ran Lu, Wei Fu, Wenhui Zhang, Haining Wang, Tianpei Hong
ABSTRACT Background: Coronavirus disease 2019 (COVID-19) is a severe infectious illness. It has been reported that COVID-19 has an effect on thyroid function. However, the association between thyroid function and prognosis of COVID-19 is still unclear. Methods: This retrospective study included patients with COVID-19 admitted to Tongji Hospital in Wuhan from January 28 to April 4, 2020. Demographic
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Sexual Dimorphism in Alternative Metabolic Pathways of L-Arginine in Circulating Leukocytes in Young People with Type 1 Diabetes Mellitus Endocr. Res. (IF 2.1) Pub Date : 2021-05-04 Nina Alchujyan, Margarita Hovhannisyan, Nina Movsesyan, Arthur Melkonyan, Vanuhi Shaboyan, Yelena Aghajanova, Grigory Minasyan, Guevork Kevorkian
ABSTRACT Background: Sexual dimorphism in specific biochemical pathways and immune response, underlies the heterogeneity of type 1 diabetes mellitus (T1DM) and affects the outcome of immunotherapy. Arginase and nitric oxide (NO) synthase (NOS) metabolize L-arginine and play opposite roles in the immune response and autoimmune processes. Objective: We hypothesized that the above mentioned enzymes can
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Comparison of the Effectiveness of Adult Height Prediction Methods in Children with Growth Hormone Deficiency Endocr. Res. (IF 2.1) Pub Date : 2021-04-26 İbrahim Mert Erbaş, Zeynep Ölmez, Ahu Paketçi, Korcan Demir, Ece Böber, Ayhan Abacı
ABSTRACT Background: In patients with growth hormone (GH) deficiency, the prediction of adult height before initiation of GH treatment can be helpful to guide clinicians and families. However, data regarding the effectiveness of prediction methods in such patients are limited. Objective: We aimed to investigate the accuracy of the three most used adult height prediction methods [Bayley-Pinneau (BP)
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Insulin Treatment May Not Be Associated with Increased Mortality in Patients with COVID-19 and Concurrent Diabetes Endocr. Res. (IF 2.1) Pub Date : 2021-02-26 Chia Siang Kow, Syed Shahzad Hasan
ABSTRACT Previous study reported that preadmission insulin treatment in patients with coronavirus disease 2019 (COVID-19) and concurrent diabetes was associated with a significantly increased odds of mortality. However, such association may be modified by possible baseline differences in glycemic control between insulin users and non-insulin users. Misinterpretation of the association between insulin
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Insulin Use and Poor COVID-19 Outcomes among Diabetes Patients: Association Not Necessarily Causation Endocr. Res. (IF 2.1) Pub Date : 2021-03-08 Shayan Riahi, Kevin Bryan Lo, Catherine Anastasopoulou, Janani Rangaswami
ABSTRACT Our study looked at the relationship between insulin use and clinical outcomes in COVID-19. A response to our article, written by Dr. Chia Sing Kow and Dr. Syed Shahzad Hasan raised a few questions. They mentioned our use of hemoglobin A1c may be inaccurate as the patients in our study had high rates of CKD or ESRD which could alter the hemoglobin A1c levels. However due to the limitations
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Editor’s Comment. Caution: The Intersection of Diabetes and COVID-19 Endocr. Res. (IF 2.1) Pub Date : 2021-03-17 Arthur Chernoff
(2021). Editor’s Comment. Caution: The Intersection of Diabetes and COVID-19. Endocrine Research: Vol. 46, No. 2, pp. 55-56.
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Relationship between Functional miR-143/145 Cluster Variants and Susceptibility to Type 2 Diabetes Mellitus: A Preliminary Case-Control Study and Bioinformatics Analyses Endocr. Res. (IF 2.1) Pub Date : 2021-04-17 Danial Jahantigh, Fariba Mirani Sargazi, Saman Sargazi, Ramin Saravani, Saeedeh Ghazaey Zidanloo, Milad Heidari Nia, Maryam Piri
ABSTRACT Purpose: To investigate the link between two variants (rs4705342 and rs4705343) in the promoter of the miR-143/145 cluster with Type 2 diabetes mellitus (T2DM) risk. Methods:A total of 1200 subjects were genotyped using the ARMS-PCR method. Results: The rs4705342 variant enhanced the risk of T2DM under codominant CC (OR = 3.24; 95% CI: 1.89–5.60), recessive TT+TC (OR = 3.02; 95% CI: 1.77–5
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Involvement of β-catenin in Androgen-induced Mesenchymal Transition of Breast MDA-MB-453 Cancer Cells Endocr. Res. (IF 2.1) Pub Date : 2021-03-11 Mamoun Ahram, Randa Bawadi, Mohammad S. Abdullah, Dana B. Alsafadi, Haneen Abaza, Sallam Abdallah, Ebtihal Mustafa
ABSTRACT Purpose The cellular and molecular dynamics of DHT-induced EMT in MDA-MB-453 cells were investigated. Methods:PCR arrays were used to examine the expression of EMT-regulatory genes. Immunoblotting was used to detect protein levels and confirm protein-protein interaction following immunoprecipitation. Immunofluorescence was used to observe rearrangement of the actin cytoskeleton and cell morphology
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The Influence of Glucocorticoid Receptor on Sex Differences of Gene Expression Profile in Skeletal Muscle Endocr. Res. (IF 2.1) Pub Date : 2021-02-16 Noritada Yoshikawa, Aya Oda, Hiroki Yamazaki, Motohisa Yamamoto, Akiko Kuribara-Souta, Masaaki Uehara, Hirotoshi Tanaka
ABSTRACT Skeletal muscle functions as a locomotory system and maintains whole-body metabolism. Sex differences in such skeletal muscle morphology and function have been documented; however, their underlying mechanisms remain elusive. Glucocorticoids are adrenocortical hormones maintaining homeostasis, including regulating whole-body energy metabolism in addition to stress response. In skeletal muscle
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The association between insulin-like growth factor 1 levels within reference range and early postoperative remission rate in patients with Cushing’s disease Endocr. Res. (IF 2.1) Pub Date : 2021-02-09 Emre Gezer, Berrin Çetinarslan, Alev Selek, Zeynep Cantürk, Mehmet Sözen, Özlem Elen, Canan Baydemir, Burak Çabuk, Savaş Ceylan
ABSTRACT Introduction The relationship between growth hormone (GH)/insulin-like growth factor 1 (IGF-1) and glucocorticoids (GC) was examined in various studies. Long-term GC treatment was shown to decrease GH concentration and, interestingly, to increase IGF-1 concentration. We performed a retrospective study in order to examine how preoperative IGF-1 concentrations vary within the reference range
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Lipoprotein(a) and Hyperinsulinemia in Healthy Normal-weight, Prepubertal Mexican Children Endocr. Res. (IF 2.1) Pub Date : 2021-02-08 Martha Rodríguez-Moran, Claudia I. Gamboa-Gómez, Lucia Preza-Rodríguez, Fernando Guerrero-Romero
ABSTRACT Background. Given the numerous gaps in our knowledge about the biological interactions of lipoprotein(a) [Lp(a)], we determined whether Lp(a) was associated with hyperinsulinemia in healthy normal-weight, prepubertal children. Methods. A total of 131 healthy normal-weight Mexican children aged 6 to 9 years at Tanner stage 1 who were born appropriate for gestational age were enrolled in a case–control
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Lipoprotein(a) and Hyperinsulinemia in Healthy Normal-weight, Prepubertal Mexican Children Endocr. Res. (IF 2.1) Pub Date : 2021-02-08 Martha Rodríguez-Moran, Claudia I. Gamboa-Gómez, Lucia Preza-Rodríguez, Fernando Guerrero-Romero
ABSTRACT Background. Given the numerous gaps in our knowledge about the biological interactions of lipoprotein(a) [Lp(a)], we determined whether Lp(a) was associated with hyperinsulinemia in healthy normal-weight, prepubertal children. Methods. A total of 131 healthy normal-weight Mexican children aged 6 to 9 years at Tanner stage 1 who were born appropriate for gestational age were enrolled in a case–control
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MTHFR Polymorphisms in Girls with Anorexia Nervosa: Implications on Body Weight Endocr. Res. (IF 2.1) Pub Date : 2021-01-28 Areti Augoulea, Eleni Armeni, Evangelia Deligeoroglou, Stavroula A. Paschou, Georgios Papadimitriou, Evgenia Stergioti, Vassilios Karountzos, Artemis Tsitsika, Konstantinos Panoulis, Emmanuel Economou, Irene Lambrinoudaki
ABSTRACT The development of atypical vs typical anorexia nervosa (AN) might be explained by the genetic background. We assessed the link between the subtypes of AN and the genetic polymorphisms of the thrombotic panel and the methyltetrahydrofolate reductase (MTHFR) gene. This cross-sectional pilot study recruited 48 girls with AN and 10 age-matched control girls with normal menstruation. We recorded
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The Association between Urinary Glucose and Renal Uric Acid Excretion in Non-diabetic Patients with Stage 1-2 Chronic Kidney Disease Endocr. Res. (IF 2.1) Pub Date : 2020-11-27 Xinhui Feng, Yuqi Zheng, Haochen Guan, Xun Zhou, Ying Xu, Xiaoli Zhang, Chensheng Fu, Jing Xiao, Zhibin Ye
ABSTRACT Aims: To test the hypothesis that in non-diabetic patients with early-stage chronic kidney disease (CKD), the renal excretion of urate and glucose transportation are coupled and interconnected. Methods: A cross-sectional study of 255 non-diabetic participants with stage 1–2 CKD recruited from our department was conducted. Spearman’s correlation and multiple linear regression analyses were
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Determination of age and sex specific TSH and FT4 reference limits in overweight and obese individuals in an iodine-replete region: Tehran Thyroid Study (TTS) Endocr. Res. (IF 2.1) Pub Date : 2020-12-07 Hengameh Abdi, Bita Faam, Safoora Gharibzadeh, Ladan Mehran, Maryam Tohidi, Fereidoun Azizi, Atieh Amouzegar
ABSTRACT Introduction: To determine age and sex-specific thyrotropin (TSH) and free thyroxine (FT4) reference ranges according to body mass index (BMI) categories. Methods: With regards to the National Academy of Clinical Biochemistry (NACB) criteria, a total of 2818 individuals from the Tehran Thyroid Study population was selected and categorized in three BMI groups. Results: TSH levels did not differ
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Effect of Vagotomy and Sympathectomy on the Feeding Responses Evoked by Intra-Aortic Cholecystokinin-8 in Adult Male Sprague Dawley Rats Endocr. Res. (IF 2.1) Pub Date : 2021-01-11 Thaer R. Mhalhal, Martha C. Washington, John C. Heath, Ayman I. Sayegh
ABSTRACT The vagus nerve and the celiaco-mesenteric ganglia (CMG) are required for reduction of meal size (MS) and prolongation of the intermeal interval (IMI) by intraperitoneal (ip) sulfated cholecystokinin-8 (CCK-8). However, recently we have shown that the gut regulates these responses. Therefore, reevaluating the role of the vagus and the CMG in the feeding responses evoked by CCK is necessary