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Increased stress hyperglycemia ratio at hospital admission in stroke patients are associated with increased in-hospital mortality and length of stay Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-16 Di Shen, Xintian Cai, Qing Zhu, Mulalibieke Heizhati, Junli Hu, Shuaiwei Song, Wenbo Yang, Jing Hong, Nanfang Li
Recently, the stress hyperglycemia ratio (SHR) has been introduced as a metric to signify relative hyperglycemia. This study aimed to investigate the relationship between SHR and in-hospital mortality and length of stay occurring during hospitalization in stroke patients. The retrospective cohort study comprised a total of 4,018 patients diagnosed with acute stroke. The SHR is expressed by the formula:
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Predictive value of insulin resistance surrogates for the development of diabetes in individuals with baseline normoglycemia: findings from two independent cohort studies in China and Japan Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-16 Qing Shangguan, Qiuling Liu, Ruijuan Yang, Shuhua Zhang, Guotai Sheng, Maobin Kuang, Yang Zou
Insulin resistance (IR) plays a crucial role in the occurrence and progression of diabetes. This study aimed to evaluate and compare the predictive value of four IR surrogates, including the triglycerides glucose (TyG) index, TyG and body mass index (TyG-BMI), triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) ratio, and the metabolic score for IR (MetS-IR) for diabetes in two large cohorts
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Predictive effect of triglyceride-glucose index on No-Reflow Phenomenon in patients with type 2 diabetes mellitus and acute myocardial infarction undergoing primary percutaneous coronary intervention Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-14 Juan Ma, Mohan Wang, Peng Wu, Xueping Ma, Dapeng Chen, Shaobin Jia, Ning Yan
Triglyceride glucose (TyG) index is considered as a new alternative marker of insulin resistance and a clinical predictor of type 2 diabetes mellitus (T2DM) combined with coronary artery disease. However, the prognostic value of TyG index on No-Reflow (NR) Phenomenon in T2DM patients with acute myocardial infarction (AMI) remains unclear. In this retrospective study, 1683 patients with T2DM and AMI
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Large-scale causal analysis of gut microbiota and six common complications of diabetes: a mendelian randomization study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-13 Jiachen Wang, Menghao Teng, Ruoyang Feng, Xiaochen Su, Ke Xu, Junxiang Wang, Guoqiang Wang, Yulong Zhang, Peng Xu
This study aimed to reveal the association between the gut microbiota (GM) and six diabetic complications: diabetic hypoglycemia; ketoacidosis; nephropathy; neuropathy; retinopathy; and Charcot’s foot. GM data were obtained from the MiBioGen consortium and Dutch Microbiome Project while data on the six diabetic complications were obtained from the FinnGen consortium. Two-sample Mendelian randomization
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Remnant cholesterol, iron status and diabetes mellitus: a dose–response relationship and mediation analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-12 Xiangming Hu, Yan Lin, Allison A. Appleton, Weimian Wang, Bingyan Yu, Langping Zhou, Guang Li, Yingling Zhou, Yanqiu Ou, Haojian Dong
Remnant cholesterol (RC) is recognized as a risk factor for diabetes mellitus (DM). Although iron status has been shown to be associated with cholesterol metabolism and DM, the association between RC, iron status, and DM remains unclear. We examined the relationship between RC and iron status and investigated the role of iron status in the association between RC and DM. A total of 7308 patients were
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Epidemiological and transcriptome data identify shared gene signatures and immune cell infiltration in type 2 diabetes and non-small cell lung cancer Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-12 Qian Yuan, Long Li, Liu-shun Wang, Shi-gui Xing
Numerous previous studies have reported an association between type 2 diabetes mellitus (T2DM) and lung cancer risk, but the underlying mechanism of the interaction remains unclear. This study aimed to investigate the shared genetic features and immune infiltration processes between lung cancer and T2DM. Epidemiological data from the National Health and Nutrition Examination Survey (NHANES) 2000–2018
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Association between insulin resistance, metabolic syndrome and its components and lung cancer: a systematic review and meta-analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-11 Jingxuan Liu, Rui Wang, Song Tan, Xiaohu Zhao, Aihua Hou
A growing body of evidence points to the association between insulin resistance (IR), metabolic syndrome (MetS) and its components and lung cancer incidence, but remains controversial and unknown. A systematic search was conducted through PubMed, Embase, Cochrane Library, the China National Knowledge Infrastructure (CNKI) and Wanfang databases for the corresponding studies. Each study reported the
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Association between insulin receptor substrate 1 gene polymorphism rs1801278 and gestational diabetes mellitus: an updated meta- analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-06 Lili Shen, Junli Liu, Xiaolei Zhao, Aiqin Wang, Xiaomei Hu
we performed this meta- analysis to investigate the impact of insulin receptor substrate 1 (IRS1) gene rs1801278 on susceptibility to gestational diabetes mellitus (GDM). The pooled odds ratio (OR) and 95% confidence interval (95% CI) were calculated, and p value is used to determine statistical significance. Sensitivity analysis was performed under three models (dominant, recessive and allele model)
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Two ferroptosis-specific expressed genes NOX4 and PARP14 are considered as potential biomarkers for the diagnosis and treatment of diabetic retinopathy and atherosclerosis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-05 Chen Li, QinHua Cai
Both Diabetic retinopathy (DR) and Atherosclerosis (AS) are common complications in patients with diabetes, and they share major pathophysiological similarities and have a common pathogenesis. Studies performed to date have demonstrated that ferroptosis plays a vital part in the occurrence and development of DR and AS, but its mechanism in the two diseases remains poorly understood. DR Chip data (GSE60436
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Associations between type 1 diabetes and pulmonary tuberculosis: a bidirectional mendelian randomization study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-05 Yijia Jiang, Wenhua Zhang, Maoying Wei, Dan Yin, Yiting Tang, Weiyu Jia, Churan Wang, Jingyi Guo, Aijing Li, Yanbing Gong
Type 1 diabetes mellitus (T1DM) has been associated with higher pulmonary tuberculosis (PTB) risk in observational studies. However, the causal relationship between them remains unclear. This study aimed to assess the causal effect between T1DM and PTB using bidirectional Mendelian randomization (MR) analysis. Single nucleotide polymorphisms (SNPs) of T1DM and PTB were extracted from the public genetic
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Causal relationship between diabetes mellitus, glycemic traits and Parkinson’s disease: a multivariable mendelian randomization analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-05 Qitong Wang, Benchi Cai, Lifan Zhong, Jitrawadee Intirach, Tao Chen
Observational studies have indicated an association between diabetes mellitus (DM), glycemic traits, and the occurrence of Parkinson’s disease (PD). However, the complex interactions between these factors and the presence of a causal relationship remain unclear. Therefore, we aim to systematically assess the causal relationship between diabetes, glycemic traits, and PD onset, risk, and progression
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Prognostic significance of the stress hyperglycemia ratio and admission blood glucose in diabetic and nondiabetic patients with spontaneous intracerebral hemorrhage Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-04 Shengru Liang, Xiaoxi Tian, Fei Gao, Minghao Man, Qi Wang, Jianwei Li, Lihong Li, Yang Yang
The role of stress hyperglycemia ratio (SHR) on the prognosis of spontaneous intracerebral hemorrhage (ICH) in patients with different diabetic status has not been elucidated. This study aimed to evaluate the prognostic value of SHR and admission blood glucose (ABG) for the short- and long-term mortality in diabetic and nondiabetic populations with ICH. Participants with ICH were retrospectively retrieved
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Gestational diabetes mellitus aggravates adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-01 Xia Li, Qin-Yu Cai, Xin Luo, Yong-Heng Wang, Li-Zhen Shao, Shu-Juan Luo, Lan Wang, Ying-Xiong Wang, Xia Lan, Tai-Hang Liu
To evaluate the effect of intrahepatic cholestasis of pregnancy (ICP) with gestational diabetes mellitus (GDM) on perinatal outcomes and establish a prediction model of adverse perinatal outcomes in women with ICP. This multicenter retrospective cohort study included the clinical data of 2,178 pregnant women with ICP, including 1,788 women with ICP and 390 co-occurrence ICP and GDM. The data of all
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Assessing the temporal within-day glycemic variability during hospitalization in patients with type 2 diabetes patients using continuous glucose monitoring: a retrospective observational study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-01 Ying Xing, Min Wu, Hongping Liu, Penghui Li, Guoming Pang, Hui Zhao, Tiancai Wen
Frequent and extensive within-day glycemic variability (GV) in blood glucose levels may increase the risk of hypoglycemia and long-term mortality in hospitalized patients with diabetes. We aimed to assess the amplitude and frequency of within-day GV in inpatients with type 2 diabetes and to explore the factors influencing within-day GV. We conducted a single-center, retrospective observational study
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Clinical outcomes of simultaneous pancreas-kidney transplantation in elderly type II diabetic recipients Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-29 Yu Cao, Jie Zhao, Gang Feng, Zhen Wang, Jianghao Wei, Yang Xu, Chunbai Mo, Wenli Song
The effect of age on outcomes after simultaneous pancreas-kidney transplantation (SPK) among type II diabetes (T2DM) recipients remains inconclusive. This study aimed to analyze the relationship between the age at time of transplantation and mortality, graft loss and metabolic profiles of T2DM SPK recipients. A retrospective cohort consisting of T2MD SPK recipients in a single transplant center was
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Correction: 2024 UPDATE: the Brazilian Diabetes Society position on the management of metabolic dysfunction‑associated steatotic liver disease (MASLD) in people with prediabetes or type 2 diabetes Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-28 Amélio F. Godoy‑Matos, Cynthia Melissa Valério, Wellington S. Silva Júnior, João Marcello de Araujo‑Neto, Marcello Casaccia Bertoluci
Correction: Diabetology & Metabolic Syndrome (2024) 16:23 https://doi.org/10.1186/s13098‑024‑01259‑2 The colour of the recommendation 8 should be changed from green to orange and the number to be changed from 1 to 11b. The original article [1] has been corrected. Changed from to Godoy‑Matos AF, Valério CM, Silva Júnior WS, de Araujo-Neto JM, Bertoluci MC. 2024 UPDATE: the Brazilian Diabetes Society
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First-trimester HbA1c in relation to plasma glucose concentrations in an oral glucose tolerance test at 12 to 16 weeks’ gestation—a population-based study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-27 Mervi Jokelainen, Hannu Kautiainen, Arja Nenonen, Beata Stach-Lempinen, Miira M. Klemetti
Early-onset GDM often requires pharmacological treatment and is associated with adverse perinatal outcomes, but data is insufficient regarding the best methods to identify high-risk women requiring early GDM screening. The aim of this study was to analyze the diagnostic accuracy of HbA1c in the prediction of (1) plasma glucose concentrations > 90th percentile in an oral glucose tolerance test (OGTT)
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Toe brachial index and not ankle brachial index is appropriate in initial evaluation of peripheral arterial disease in type 2 diabetes Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-27 Pankaj Singhania, Tapas Chandra Das, Chiranjit Bose, Asif Mondal, Rana Bhattacharjee, Archana Singh, Satinath Mukhopadhyay, Subhankar Chowdhury
Non-invasive clinic-based tools for assessing PAD are not without limitations. Therefore, costly tests like Doppler study, CT angiography and MR angiography are often required to make a diagnosis. Ankle brachial index (ABI), commonly used for assessment of PAD, has high false positivity rates in sclerosed, calcified arteries which render them non-compressible. Toe brachial index (TBI) can be an alternative
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Increased susceptibility to new-onset atrial fibrillation in diabetic women with poor sleep behaviour traits: findings from the prospective cohort study in the UK Biobank Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-27 Siwei Chen, Zhou Liu, Shaohua Yan, Zhongyan Du, Wenke Cheng
Diabetic individuals often encounter various sleep-related challenges. Although the association between sleep duration and atrial fibrillation (AF) have been explored, the association of other sleep traits with the incidence of AF remains unclear. A comprehensive understanding of these traits is essential for a more accurate assessment of sleep conditions in patients with diabetes and the development
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High dietary inflammatory index associates with inflammatory proteins in plasma Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-26 Elisa Mattavelli, Elisa Piperni, Francesco Asnicar, Laura Redaelli, Liliana Grigore, Fabio Pellegatta, Amir Nabinejad, Sabrina Tamburini, Nicola Segata, Alberico Luigi Catapano, Andrea Baragetti
Unhealthy dietary habits and highly caloric foods induce metabolic alterations and promote the development of the inflammatory consequences of obesity, insulin resistance, diabetes and cardiovascular diseases. Describing an inflammatory effect of diet is difficult to pursue, owing lacks of standardized quali-quantitative dietary assessments. The Dietary Inflammatory Index (DII) has been proposed as
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Single-cell RNA sequencing reveals roles of unique retinal microglia types in early diabetic retinopathy Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-26 Yan Wang, Xiongyi Yang, Yuxi Zhang, Libing Hong, Zhuohang Xie, Wenmin Jiang, Lin Chen, Ke Xiong, Siyu Yang, Meiping Lin, Xi Guo, Qiumo Li, Xiaoqing Deng, Yanhui Lin, Mingzhe Cao, Guoguo Yi, Min Fu
The pathophysiological mechanisms of diabetic retinopathy (DR), a blinding disease, are intricate. DR was thought to be a microvascular disease previously. However, growing studies have indicated that the retinal microglia-induced inflammation precedes microangiopathy. The binary concept of microglial M1/M2 polarization paradigms during inflammatory activation has been debated. In this study, we confirmed
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Comparative effectiveness of different modes of exercise interventions in diabetics with frailty in China: a systematic review and a network meta-analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-26 Liu Qin, Peng Junjie, Wei Xinhong, Fang Shengju, Sun Ruifen
To systematically evaluate the efficacy of different training modes in patients with diabetes decline. PubMed, Cochrane Library, EMbase, Web of Science, CNKI, VIP, WANFANG, SinoMed were searched in computer to collect randomized controlled trials (RCTs) of training intervention in patients with diabetes and frailty, and the search time was as of May 21, 2023. After two review authors independently
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Role of gastric bypass surgery in control of blood sugar in obese uncontrolled type 2 diabetic patients Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-19 Hala Khalf Allah El-Shreef, Osama Yaseen Mostafa Taha, Heba Elsayed Ahmed Abdellatif, Amal Ibrahim Abd El-Rheem Abo Shoka
The pandemic of the twenty-first century is diabetes. Both type 2 diabetes mellitus and obesity pose severe problems for public health. Despite significant improvements in diagnosing and managing both conditions, diabetes mellitus remains poorly controlled, and diabetic complications are more common than ever. Internists have discovered over the past 20 years that obese people with type 2 diabetes
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SGLT2i relieve proteinuria in diabetic nephropathy patients potentially by inhibiting renal oxidative stress rather than through AGEs pathway Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-16 Xiao-chun Zeng, Yuan Tian, Xian-ming Liang, Xiao-bin Wu, Chun-meng Yao, Xiao-min Chen
To estimate the effects of the sodium-glucose cotransporter 2 inhibitor (SGLT2i) on proteinuria and oxidative stress expression in type 2 diabetes patients. 68 patients with type 2 diabetes mellitus (T2DM) were divided into three groups according urinary albumin-to-creatinine ratio (UACR), including T2DM with non-albuminuria group (UACR < 30 mg/g), T2DM with microalbuminuria group (30 ≤ UACR ≤ 300 mg/g)
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The intervention of cannabinoid receptor in chronic and acute kidney disease animal models: a systematic review and meta-analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-15 Zihao Zhao, Qianqian Yan, Junwei Xie, Zhenjie Liu, Fengxun Liu, Yong Liu, Sijie Zhou, Shaokang Pan, Dongwei Liu, Jiayu Duan, Zhangsuo Liu
Cannabinoid receptors are components of the endocannabinoid system that affect various physiological functions. We aim to investigate the effect of cannabinoid receptor modulation on kidney disease. PubMed, Web of Science databases, and EMBASE were searched. Articles selection, data extraction and quality assessment were independently performed by two investigators. The SYRCLE’s RoB tool was used to
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Stress-induced hyperglycemia is associated with the mortality of thrombotic thrombocytopenic purpura patients Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-15 Lingling Hu, Jing Wang, Xiaxia Jin, Guoguang Lu, Meidan Fang, Jian Shen, Tao-Hsin Tung, Bo Shen
Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy with a rapid progression and high mortality rate. We aimed to explore early risk factors for mortality in patients with TTP. We conducted a retrospective analysis of 42 TTP patients that were admitted to our hospital between 2000 and 2021, with a median age of 49 (29–63) years. Risk factors for mortality were evaluated using
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Global trends and developments in mindfulness interventions for diabetes: a bibliometric study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-15 Sijia Jiang, Xiaoli Pan, Hansen Li, Yuqin Su
Diabetes is a metabolic disorder posing a global threat to health. Many scholars are dedicated to developing non-pharmacological therapies, and mindfulness intervention is among the potentially effective approaches. Due to the rapid increase in relevant research in recent years, along with the diverse focus and interventions used in studies, it has become challenging for practitioners to quickly comprehend
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Clinical inertia in newly diagnosed type 2 diabetes mellitus among patients attending selected healthcare institutions in Colombia Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-15 Nelson Alvis-Guzman, Martín Romero, Fernando Salcedo-Mejia, Maria Carrasquilla-Sotomayor, Lina Gómez, Mónica María Rojas, Juan Camilo Urrego, Claudia Catalina Beltrán, Jaime Enrique Ruíz, Adriana Velásquez, Juan Carlos Orengo, Adolfo Pinzón
The burden of disease of diabetes in Colombia have increased in the last decades. Secondary prevention is crucial for diabetes control. Many patients already treated remain with poor glycemic control and without timely and appropriate treatment intensification. This has been called in the literature as Clinical Inertia. Updated information regarding clinical inertia based on the Colombian diabetes
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Early signs of myocardial systolic dysfunction in patients with type 2 diabetes are strongly associated with myocardial microvascular dysfunction independent of myocardial fibrosis: a prospective cohort study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-13 Annemie S. Bojer, Martin H. Sørensen, Stine H. Madsen, David A. Broadbent, Sven Plein, Peter Gæde, Per L. Madsen
Patients with diabetes demonstrate early left ventricular systolic dysfunction. Notably reduced global longitudinal strain (GLS) is related to poor outcomes, the underlying pathophysiology is however still not clearly understood. We hypothesized that pathophysiologic changes with microvascular dysfunction and interstitial fibrosis contribute to reduced strain. 211 patients with type 2 diabetes and
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Sacubitril/valsartan ameliorates tubulointerstitial fibrosis by restoring mitochondrial homeostasis in diabetic kidney disease Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-10 Xing-Jian Zhang, Cong-Cong Liu, Zuo-Lin Li, Lin Ding, Yan Zhou, Dong-Jie Zhang, Yao Zhang, Shu-Ting Hou, Rui-Xia Ma
Tubulointerstitial fibrosis plays an important role in the progression of diabetic kidney disease (DKD). Sacubitril/valsartan (Sac/Val) exerts a robust beneficial effect in DKD. However, the potential functional effect of Sac/Val on tubulointerstitial fibrosis in DKD is still largely unclear. Streptozotocin-induced diabetic mice were given Sac/Val or Val by intragastric administration once a day for
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Pancreatic enzyme replacement therapy in subjects with exocrine pancreatic insufficiency and diabetes mellitus: a real-life, case–control study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-09 Laure Alexandre-Heymann, Fetta Yaker, Pierre Bel Lassen, Danièle Dubois-Laforgue, Etienne Larger
Exocrine pancreatic insufficiency (EPI) can be associated with all types of diabetes. Pancreatic enzyme replacement therapy (PERT) has short and long-term benefits in subjects with EPI, but its effects on diabetes control are uncertain. We aimed to study the effects of PERT initiation on glycemic control in subjects with diabetes and EPI from any cause. In this retrospective study, we compared subjects
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Dapagliflozin improves podocytes injury in diabetic nephropathy via regulating cholesterol balance through KLF5 targeting the ABCA1 signalling pathway Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-07 Jingshu Sun, Xinyu Zhang, Simeng Wang, Dandan Chen, Jianqiang Shu, Nannan Chong, Qinglian Wang, Ying Xu
Diabetic nephropathy (DN), one of the more prevalent microvascular complications in patients diagnosed with diabetes mellitus, is attributed as the main cause of end-stage renal disease (ESRD). Lipotoxicity in podocytes caused by hyperglycemia has been recognised as a significant pathology change, resulting in the deterioration of the glomerular filtration barrier. Research has demonstrated how dapagliflozin
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Exosomes derived from BMSCs enhance diabetic wound healing through circ-Snhg11 delivery Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-07 Tao Tang, Linyi Chen, Ming Zhang, Chuang Wang, Xiaolong Du, Shenglin Ye, Xiaoqiang Li, Hong Chen, Nan Hu
Exosomes (Exos) generated from bone mesenchymal stem cells (BMSCs) are elucidated to enhance cutaneous wound healing in mice models of diabetes mellitus (DM). While underlying mechanisms remain unknown. Next-generation sequencing (NGS) was used to examine changes in circRNA expression levels following Exo treatment. Luciferase assays were used to determine the interactions between RNAs. Immunofluorescence
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Correction: The interrelationship and accumulation of cardiometabolic risk factors amongst young adults in the United Arab Emirates: The UAE Healthy Future Study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-07 Fatima Mezhal, Abderrahim Oulhaj, Abdishakur Abdulle, Abdulla AlJunaibi, Abdulla Alnaeemi, Amar Ahmad, Andrea Leinberger‑Jabari, Ayesha S. Al Dhaheri, E. Murat Tuzcu, Eiman AlZaabi, Fatma Al‑Maskari, Fatme Alanouti, Fayza Alameri, Habiba Alsafar, Hamad Alblooshi, Juma Alkaabi, Laila Abdel Wareth, Mai Aljaber, Marina Kazim, Micheal Weitzman, Mohammad Al‑Houqani, Mohammad Hag Ali, Naima Oumeziane, Omar
Correction: Diabetology & Metabolic Syndrome (2021) 13:140 https://doi.org/10.1186/s13098-021-00758-w Following publication of the original article [1], the authors identified an error in Table 3. The word “Dyslipidemia” should be removed from Hypertension column. The correct Table 3 is given below. Table 3 Odd ratios of the associations between the cardiometabolic risk factors adjusted for age and
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Long noncoding RNA XIST promotes cell proliferation and migration in diabetic foot ulcers through the miR-126-3p/EGFR axis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-06 Wangbing Hong, Zhenfang Xiong, Xin Wang, Xincheng Liao, Mingzhuo Liu, Zhengying Jiang, Dinghong Min, Jiaqi Li, Guanghua Guo, Zhonghua Fu
The prevalence of diabetic foot ulcers (DFUs) has caused serious harm to human health. To date, a highly effective treatment is lacking. Long noncoding RNA X-inactive specific transcript (lncRNA XIST) has been the subject of mounting research studies, all of which have found that it serves as a protective factor against certain diseases; however, its function in DFUs is not entirely understood. This
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Current and past depression as risk factors for incident type 2 diabetes mellitus and pre-diabetes in men and women: evidence from a longitudinal community cohort Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-01 Felix S. Wicke, Daniëlle Otten, Andreas Schulz, Philipp S. Wild, Karl J. Lackner, Thomas Münzel, Jochem König, Mareike Ernst, Jörg Wiltink, Iris Reiner, Jasmin Ghaemi Kerahrodi, Norbert Pfeiffer, Manfred E. Beutel
Depression is associated with an increased risk for type 2 diabetes mellitus. However, depression may take different courses, and it is not fully understood how these affect the development of diabetes. It is further to be determined whether sex modifies the association between depression and type 2 diabetes. We analyzed data from the Gutenberg Health Study, a longitudinal and population-based cohort
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Leptin receptor deficiency impedes metabolic surgery related-weight loss through inhibition of energy expenditure in db/db mice Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-01 Dan Tong, Jie Xiang, Wei Liu, Fang Sun, Lijuan Wang, Aidi Mou, Tingbing Cao, Qing Zhou, Mei You, Yingying Liao, Peng Gao, Daoyan Liu, Zongshi Lu, Zhiming Zhu
Roux-en-Y gastric bypass (RYGB) surgery is an effective metabolic surgery against diabetes and obesity. Clinical evidence indicates that patients with severe obesity have a poor curative effect in losing weight if they suffer from leptin or its receptor deficiency, but the underlying mechanism remains elusive. Here, we investigated the effect of leptin receptor deficiency on metabolic dysfunction in
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Stress hyperglycemia increases short-term mortality in acute ischemic stroke patients after mechanical thrombectomy Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-31 Bing Yang, Xuefang Chen, Fangze Li, Junrun Zhang, Dawei Dong, Huiyue Ou, Longyan Lu, Niu He, Xiaohong Xu, Xiufeng Xin, Jingchong Lu, Min Guan, Hongyu Qiao, Anding Xu, Huili Zhu
Glucose-to-glycated hemoglobin ratio (GAR) is considered a more reliable marker of stress hyperglycemia by correcting for basal blood glucose levels. This study aimed to investigate the extent to which GAR is associated with 3 month and 1 year all-cause mortalities in patients with acute ischemic stroke (AIS) undergoing mechanical thrombectomy (MT). We retrospectively followed 553 AIS patients who
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Prevalence of autoimmune diseases in an admixed population of patients with type 1 diabetes: a multicenter study in Brazil Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-31 Marilia Brito Gomes, Fernanda Oliveira Braga, Karla Guerra Drummond, André Pinheiro, Franz Leal, Luís Cristóvão Porto, Livia Leite Ferreira, Geraldo da Rocha Castelar Pinheiro, Carlos Antonio Negrato
The primary aim of this study was to evaluate the prevalence of autoimmune diseases (AIDs) and its associated factors in an admixed Brazilian population of patients with type 1 diabetes (T1D). The secondary one was to determine the relationship between AIDs and the occurrence of diabetes-related chronic complications (DRCC). This cross-sectional, nationwide survey was conducted in 13 public clinics
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An elevated urinary albumin-to-creatinine ratio increases the risk of incident cardia-cerebrovascular disease in individuals with type 2 diabetes Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-31 Jie Tao, Dasen Sang, Xinxin Zhang, Xin Liu, Guodong Wang, Shuohua Chen, Shouling Wu, Wei Geng
We aimed to explore the associations between urine albumin-to-creatinine ratio (uACR) and cardia-cerebrovascular disease (CVD) in Chinese population with type 2 diabetes(T2D). We included 8975 participants with T2D but free of prevalent CVD (including myocardial infarction, ischemic and hemorrhagic stroke) at baseline from Kailuan study who were assessed with uACR between 2014 and 2016. The participants
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A higher TyG index level is more likely to have enhanced incidence of T2DM and HTN comorbidity in elderly Chinese people: a prospective observational study from the reaction study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-30 Wanlu Su, Jie Wang, Kang Chen, Wenhua Yan, Zhengnan Gao, Xulei Tang, Qin Wan, Zuojie Luo, Guang Ning, Yiming Mu
Triglyceride glucose index (TyG index) was related with both type 2 diabetes (T2DM) and hypertension (HTN). Prospective studies linking the TyG index to the incidence of T2DM and HTN comorbidity remain unclear. This study aimed to to explore the longitudinal association between TyG and new-onset T2DM with HTN. 4,434 subjects (1249 males and 3185 females) without initial T2DM and HTN were followed up
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Covid 19 and diabetes in children: advances and strategies Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-29 Zhaoyuan Wu, Jinling Wang, Rahim Ullah, Minghao Chen, Ke Huang, Guanping Dong, Junfen Fu
Throughout the COVID-19 pandemic, there has been a notable increase in the incidence of new-onset diabetes and diabetic ketoacidosis (DKA). Simultaneously, children diagnosed with type 1 diabetes (T1D) have encountered difficulties in maintaining optimal blood glucose levels. The mechanisms underpinning these correlations still remain a puzzle. We reviewed the studies that examined changes in incidence
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The impact of obesity on different glucose tolerance status with incident cardiovascular disease and mortality events over 15 years of follow-up: a pooled cohort analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-25 Samaneh Asgari, Danial Molavizadeh, Kiarash soltani, Davood Khalili, Fereidoun Azizi, Farzad Hadaegh
The effect of obesity in different glucose tolerance statuses i.e. normoglycemia (NGT), pre-diabetes, and type 2 diabetes (T2DM) on cardiovascular disease (CVD) and mortality has been an area of ongoing debate and uncertainty. In the present study, we aimed to examine the impact of being obese, whether general or central separately, in comparison with non-obese in different glucose tolerance statuses
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Distinct changes to pancreatic volume rather than pancreatic autoantibody positivity: insights into immune checkpoint inhibitors induced diabetes mellitus Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-23 Hung-Hui Wei, Ying-Chieh Lai, Gigin Lin, Cheng-Wei Lin, Ya-Chu Chang, John Wen-Cheng Chang, Miaw-Jene Liou, I-Wen Chen
Immune checkpoint inhibitors (ICI) are promising treatment options for various cancers. However, their use is associated with immune-related adverse events (irAEs), including ICI-induced diabetes mellitus (ICI-DM). This study aimed to investigate the clinical features of ICI-DM, with a particular focus on alterations to pancreatic volume. We conducted a retrospective review of 2829 patients who received
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Comparison of the efficacy of fish oil and probiotic supplementation on glucose and lipid metabolism in patients with type 2 diabetes: a systematic review and network meta-analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-22 Mei Zhang, Fan Yang, Qiu Feng, Yanghong Ou, Jiaxing Zhang, Haiyan Wan, Hongyi Cao, Peng Ning
Abnormalities in glucose and lipid metabolism contribute to the progression and exacerbation of type 2 diabetes mellitus (T2DM). Fish oil and probiotics are dietary supplements that have the potential to improve glucose and lipid metabolism. However, their efficacy remains unclear in T2DM patients. PubMed, Embase, and the Cochrane Library were retrieved to collect randomized controlled trials (RCTs)
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Relationship between gout, hyperuricemia, and obesity—does central obesity play a significant role?—a study based on the NHANES database Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-22 Tongjun Mao, Qian He, Junping Yang, Lanlan Jia, Guofei Xu
Our objective was to evaluate how various measures of obesity, such as body mass index(BMI), body roundness index(BRI), and weigh adjusted waist index(WWI), influence urate levels, prevalence of gout and to compare the disparities among these obesity indicators. By analyzing the 2001–2018 National Health and Nutrition Examination Survey (NHANES), we assessed the relationship between BMI, WWI, and BRI
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2024 UPDATE: the Brazilian Diabetes Society position on the management of metabolic dysfunction-associated steatotic liver disease (MASLD) in people with prediabetes or type 2 diabetes Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-19 Amélio F. Godoy-Matos, Cynthia Melissa Valério, Wellington S. Silva Júnior, João Marcello de Araujo-Neto, Marcello Casaccia Bertoluci
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease affecting 30% of the world’s population and is often associated with metabolic disorders such as metabolic syndrome, type 2 diabetes (T2D), and cardiovascular disease. This review is an update of the Brazilian Diabetes Society (Sociedade Brasileira de Diabetes [SBD]) evidence-based guideline for the management
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Anthropometric parameters as a tool for the prediction of metabolic and cardiovascular risk in childhood brain tumor survivors Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-19 Alberto Romano, Mariapia Masino, Serena Rivetti, Stefano Mastrangelo, Giorgio Attinà, Palma Maurizi, Antonio Ruggiero
To assess the prevalence of alterations in anthropometric parameters predictive of metabolic syndrome and cardiovascular risk among childhood brain tumor survivors. Anthropometric parameters predictive of metabolic syndrome and cardiovascular risk were analyzed [height, weight, BMI, waist circumference, hip circumference, waist-height ratio (WHtR), waist-hip ratio (WHR, blood pressure] of 25 patients
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Metabolomics analysis of serum and urine in type 1 diabetes patients with different time in range derived from continuous glucose monitoring Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-19 Liyuan Ma, Jieying Liu, Mingqun Deng, Liyuan Zhou, Qian Zhang, Xinhua Xiao
Time in range (TIR), as an important glycemic variability (GV) index, is clearly associated with disease complications in type 1 diabetes (T1D). Metabolic dysregulation is also involved in the risks of T1D complications. However, the relationship between metabolites and TIR remains poorly understood. We used metabolomics to investigate metabolic profile changes in T1D patients with different TIR. This
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The impact of obesity in hospitalized patients with COVID-19: a retrospective cohort study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-19 Fábio Alfano Carra, Maria Edna de Melo, Matheo A. M. Stumpf, Cintia Cercato, Ariana E. Fernandes, Marcio C. Mancini
Obesity is believed to be a risk factor for COVID-19 and unfavorable outcomes, although data on this remains to be better elucidated. To evaluate the impact of obesity on the endpoints of patients hospitalized due to SARS-CoV-2. This retrospective cohort study evaluated patients hospitalized at a tertiary hospital (Hospital das Clínicas da Faculdade de Medicina da USP) from March to December 2020.
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Liver indicators affecting the relationship between BMI and hypertension in type 2 diabetes: a mediation analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-17 Xuelin Yao, Keyan Hu, Zhen Wang, Fangting Lu, Jie Zhang, Yahu Miao, Qing Feng, Tian Jiang, Yi Zhang, Songtao Tang, Nan Zhang, Fang Dai, Honglin Hu, Qiu Zhang
Body mass index (BMI) is an important risk factor for hypertension in diabetic patients. However, the underlying mechanisms remain poorly understood. Although liver-derived biological intermediates may play irreplaceable roles in the pathophysiology of diabetes, few studies have explored them in the association between BMI and hypertension in diabetes. To investigate the role of liver enzymes in mediating
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High glucose-induced injury in human umbilical vein endothelial cells is alleviated by vitamin D supplementation through downregulation of TIPE1 Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-13 Zhoujun Liu, Haogang Sun, Yu Chen, Jia He, Lin Zhu, Bing Yang, Wenzhuo Zhao
Diabetes mellitus (DM) and its associated vascular complications have become a worldwide health concern. The effects and mechanism of vitamin D supplementation on endothelial function under high glucose condition remain elusive. Human umbilical vein endothelial cells (HUVECs) were treated with 35 mM glucose, then 100 nM vitamin D were added. Transwell migration assay, CCK-8, immunofluorescence, flow
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The association between gestational weight trajectories in women with gestational diabetes and their offspring's weight from birth to 40 months Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-13 Wei Zheng, Jia Wang, Yichen Li, Xiaorui Shang, Kaiwen Ma, Xianxian Yuan, Kexin Zhang, Ruihua Yang, Yuru Ma, Guanghui Li
To identify the gestational weight gain (GWG) patterns in women with gestational diabetes mellitus (GDM) and evaluate their association with offspring weight status from birth to 40 months. This study included 2,723 GDM-mother–child pairs from the Beijing Birth Cohort Study. The association between GWG trajectories identified by the latent class model and offspring weight outcomes from birth to 40 months
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GRP78 protein metabolism in obese and diabetic rats: a study of its role in metabolic disorders Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-13 Kai Xi, Hua-Ping Li, Yue-Hui Wang, Yang-Yang Li, Lei Wang, Miao-Miao Zhang, Xi Zhang, Bing-Wen Xing
This study aimed to compare and analyze the expression and significance of the GRP78 protein in cochlear cell injury induced by a high glucose and high-fat diet in obese and diabetic rats. Male SD rats were randomly divided into two groups: normal (NC) and high-fat (HF) groups. The NC group was fed a standard diet for eight weeks, while the HF group received a high-glucose, high-fat diet. The HF group
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Sleep patterns and risks of incident cardiovascular disease and mortality among people with type 2 diabetes: a prospective study of the UK Biobank Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-11 Jinxia Hu, Xuanyang Wang, Licheng Cheng, Keke Dang, Zhu Ming, Xinmiao Tao, Xiaoqing Xu, Shuvan Kumar Sarker, Ying Li
To explore the relationship between sleep patterns and cardiovascular disease (CVD) incidence and mortality risk in a population with type 2 diabetes through a UK Biobank sample. A total of 6860 patients with type 2 diabetes were included in this study. Five sleep factors (including Chronotype, sleep duration, insomnia, daytime sleepiness, and snoring) were collected as a questionnaire. The calculation
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Effects of finerenone and glucagon-like peptide 1 receptor agonists on cardiovascular and renal outcomes in type 2 diabetes mellitus: a systematic review and meta-analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-11 Xia Gu, Shimin Jiang, Yue Yang, Wenge Li
To assess the effects of finerenone and glucagon-like peptide 1 receptor agonists (GLP1-RA) on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus (T2DM), and the relative cardiovascular benefits in patients with or without established atherosclerotic cardiovascular disease for different outcomes with these classes of drugs. We searched PubMed, the Cochrane Library, and Embase
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Insulin resistance-related features are associated with cognitive decline: a cross-sectional study in adult patients with type 1 diabetes Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-11 Xiaolin Ji, Wenjing Zou, Li Fan, Zhiguang Zhou, Xiongzhao Zhu, Xia Li
To investigate the associations between insulin resistance (IR)-related features and cognitive function in type 1 diabetes (T1D). A total of 117 adult patients with T1D were recruited in this cross-sectional study. IR-related features include overweight/obesity/central obesity, hypertension, atherogenic dyslipidemia, and decreased estimated insulin sensitivity (eIS). The Wechsler Memory Scale-Chinese
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Lipid-lowering drugs and inflammatory bowel disease’s risk: a drug-target Mendelian randomization study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-09 Jiaxi Zhao, Rong Chen, Mengqi Luo, Hongping Gong, Kaixin Li, Qian Zhao
Inflammatory bowel disease (IBD) has been associated with lipid-lowering drugs in observational studies. Drug-target Mendelian randomization (MR) was utilized in this study to examine the causal relationship between lipid-lowering drugs and incidence of IBD, aiming to identify new preventive uses for the drugs. We identified instrumental variables for three classes of lipid-lowering drugs: HMGCR inhibitors
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Connections between body composition and dysregulation of islet α- and β-cells in type 2 diabetes Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-09 Jia-xi Miao, Jia-ping Xu, Rui Wang, Yu-xian Xu, Feng Xu, Chun-hua Wang, Chao Yu, Dong-mei Zhang, Jian-bin Su
Accompanying islet α- and β-cell dysregulation in type 2 diabetes (T2D) at the microscopic scale, alterations in body composition at the macroscopic scale may affect the pathogenesis of T2D. However, the connections between body composition and islet α-cell and β-cell functions in T2D have not been thoroughly explored. For this cross-sectional study, we recruited a total of 729 Chinese Han patients
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A comparative study of cardiovascular risk stratification methods in type 1 diabetes mellitus patients Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-01-09 Fabiano Malard de Araujo, Fábio Vasconcellos Comim, Rodrigo N. Lamounier, Natália F. Pena, Virgínia C. Fajardo, Regina Bicalho G. de Faria, Yuri M. Silva, Márcio Weissheimer Lauria
The Steno Diabetes Center Copenhagen developed the Steno T1 Risk Engine (ST1RE) to predict cardiovascular events, encompassing fatal and nonfatal ischemic heart disease, ischemic stroke, heart failure, and peripheral arterial disease in type 1 diabetes mellitus(T1DM). The current study investigated the agreement between ST1RE and the Brazilian Society for Endocrinology and Metabology (SBEM) classification