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Regional modulation of toll-like receptor signaling pathway genes in acute epididymitis in mice Andrology (IF 4.5) Pub Date : 2024-03-18 Alexandre D. Andrade, Priscila G. C. Almeida, Noemia A. P. Mariani, Natalia C. M. Santos, Isabela A. Camargo, Poliana V. Martini, Helio Kushima, Dingding Ai, Maria Christina W. Avellar, Andreas Meinhardt, Christiane Pleuger, Erick J. R. Silva
Region-specific immune environments in the epididymis influence the immune responses to uropathogenic Escherichia coli (UPEC) infection, a relevant cause of epididymitis in men. Toll-like receptors (TLRs) are essential to orchestrate immune responses against bacterial infections. The epididymis displays region-specific inflammatory responses to bacterial-derived TLR agonists, such as lipopolysaccharide
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Testosterone therapy in men with classical versus functional hypogonadism: results from a controlled 9‐years, real‐world registry study Andrology (IF 4.5) Pub Date : 2024-03-16 Michael Zitzmann, Jann‐Frederik Cremers, Claudia Krallmann, Armin Soave, Sabine Kliesch
Background and objectiveThe longitudinal efficacy and clinical utility of Testosterone Therapy (TTh) in ameliorating functional hypogonadism (FH) remain contentious, with long‐term data being scarce. To address this lacuna, a comprehensive long‐term registry study, stratifying patients across a spectrum of hypogonadal etiologies, offers a robust investigative paradigm.Materials and methodsThis 9‐year
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Maternal use of nitrosatable drugs during pregnancy and adult male reproductive health: A population‐based cohort study Andrology (IF 4.5) Pub Date : 2024-03-16 Pernille Jul Clemmensen, Nis Brix, Jörg Schullehner, Gunnar Toft, Sandra Søgaard Tøttenborg, Karin Sørig Hougaard, Anne Ahrendt Bjerregaard, Thorhallur Ingi Halldorsson, Sjurdur Frodi Olsen, Birgitte Hansen, Leslie Thomas Stayner, Torben Sigsgaard, Henrik Kolstad, Jens Peter Ellekilde Bonde, Cecilia Høst Ramlau‐Hansen
BackgroundPrenatal exposures to xenobiotics during the masculinization programming window are suggested to impact male fecundity later in life. Frequently used nitrosatable drugs, such as penicillins and beta2‐agonists, contain amines or amides that may form teratogenic compounds in reaction with nitrite.ObjectivesWe explored whether maternal nitrosatable drug use during gestation was associated with
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Associations between a paternal healthy lifestyle score and its individual components with childhood overweight and obesity Andrology (IF 4.5) Pub Date : 2024-03-13 Adrien M. Aubert, Alexander Douglass, Celine M. Murrin, Cecily C. Kelleher, Catherine M. Phillips
Maternal healthy lifestyle behaviors during pregnancy have been associated with reduced risk of offspring overweight and obesity (OWOB). However, there has been little investigation, in the context of the Paternal Origins of Health and Disease (POHaD) paradigm, of the potential influence of the paternal lifestyle on offspring OWOB.
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Effects of edaravone on testicular torsion–detorsion injury in rats Andrology (IF 4.5) Pub Date : 2024-03-14 Yaşar Şahin, Evren Üstüner, Hidayet Tutun, Ebru Yildirim, Oğuz Eroğlu, Efe Kurtdede, Yasin Ozkabadayi, Enes Güncüm, Kürşat Kutluca, Ahmet Bilgehan Bilge
Background and objectiveThis study aimed to assess the protective ability of edaravone on testicular torsion–detorsion injury in rats.MethodsEighteen adult male Sprague–Dawley rats were randomly divided into three groups: Sham group (control, n = 6); testicular torsion/detorsion (T/D group, n = 6) and T/D+edaravone (T/D+E group, n = 6). The spermatic cords of rats of the T/D group and the T/D+E group
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Effects of chronic mild stress induced from peripuberty on sexual behavior in male rats, with or without escitalopram treatment Andrology (IF 4.5) Pub Date : 2024-03-14 Leonardo Wensing Fischer, Marina Nunes, Talita Biude Mendes, Joana Noguères Simas, Maria Martha Bernardi, Samara Urban de Oliva, Sandra Maria Miraglia
BackgroundAfter the Coronavirus Disease pandemic, depression became more present, including in adolescents. Escitalopram, a selective serotonin reuptake inhibitor, was approved in 2009 for treatment of the major depressive disorder, both in children and adolescents. The undesirable effects of antidepressants on sexual dysfunction are usually underestimated.AimsTo investigate the effects of chronic
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Pubertal testicular volume references for ruler, orchidometer, and ultrasonography measurements based on a longitudinal follow‐up Andrology (IF 4.5) Pub Date : 2024-03-14 Mikael Koskela, Helena E. Virtanen, Wiwat Rodprasert, Kirsi Jahnukainen, Jorma Toppari, Jaakko J. Koskenniemi
BackgroundTesticular volume is a marker of male pubertal development. Various clinical conditions and their treatments may influence testicular growth.ObjectivesTo create ruler‐based age‐dependent pubertal testicular volume references that enable calculation of standard deviation (SD) scores.Materials and MethodsStudy cohort comprised 65 boys who attended clinical examination twice a year from the
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Summer heat during spermatogenesis reduces in vitro blastocyst rates and affects sperm quality of next generation bulls Andrology (IF 4.5) Pub Date : 2024-03-13 Jens Vanselow, Claudia Wesenauer, Anja Eggert, Arpna Sharma, Frank Becker
BackgroundDue to global warming seasonal heat stress is an increasing problem in temperate zones. Heat stress not only decreases fertility in females, but can also be detrimental to male fertility.ObjectivesWe studied the effects of natural summer heat stress during spermatogenesis in Holstein bulls on semen quality parameters and on fertilization performance in vitro and possible intergenerational
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Transmission electron microscopy reveals the presence of SARS‐CoV‐2 in human spermatozoa associated with an ETosis‐like response Andrology (IF 4.5) Pub Date : 2024-03-12 Jorge Hallak, Elia G. Caldini, Thiago A. Teixeira, Maria Cassia Mendes Correa, Amaro N. Duarte‐Neto, Fabiola Zambrano, Anja Taubert, Carlos Hermosilla, Joël R. Drevet, Marisa Dolhnikoff, Raul Sanchez, Paulo H. N. Saldiva
BackgroundSevere acute syndrome coronavirus 2 can invade a variety of tissues, including the testis. Even though this virus is scarcely found in human semen polymerase chain reaction tests, autopsy studies confirm the viral presence in all testicular cell types, including spermatozoa and spermatids.ObjectiveTo investigate whether the severe acute syndrome coronavirus 2 is present inside the spermatozoa
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Sex differences on constitutive long non‐coding RNA expression: Modulatory effect of estradiol and testosterone in muscle cells Andrology (IF 4.5) Pub Date : 2024-03-12 Tresa López‐Royo, Laura Moreno‐Martínez, Leticia Moreno‐García, Ana Cristina Calvo, Raquel Manzano, Rosario Osta
IntroductionDespite the growing awareness of sexual dimorphism between males and females under pathological and physiological conditions, sex bias in biomedical research in animal models and patients is still present nowadays. The main objective of this work was to investigate sex differences in constitutive long non‐coding RNA expression in spinal cord and skeletal muscle from wild‐type mice.Materials
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Swimming trapper decreases the proportion of chromosomally unbalanced spermatozoa in human Robertsonian translocation carriers Andrology (IF 4.5) Pub Date : 2024-03-11 Xiao‐Nan Liu, Mei‐Yi Li, Qing‐Ling Ma, Juan Chen, Shuai Liu, Yang Yu, Ling Sun
BackgroundCarriers of reciprocal translocations often have more unbalanced spermatozoa and higher DNA fragmentation rates, elevating reproductive risk. The simple swim‐up method (SSUM) can decrease the amount of spermatozoa with abnormal chromatin structure and fragmented DNA, however, it has limited efficacy in eliminating chromosomally unbalanced sperm.MethodsThe spermatozoa of eight Robertsonian
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A preconception cohort study of sugar‐sweetened beverage consumption and semen quality Andrology (IF 4.5) Pub Date : 2024-03-07 Marlon D. Joseph, Martha R. Koenig, Andrea S. Kuriyama, Tanran R. Wang, Amelia K. Wesselink, Michael L. Eisenberg, Greg J. Sommer, Kenneth J. Rothman, Sherri O. Stuver, Lauren A. Wise, Elizabeth E. Hatch
BackgroundDietary factors, including high sugar intake, may have adverse effects on male reproduction. Studies of the association between sugar‐sweetened beverage (SSB) intake and semen quality have reported inconsistent results.ObjectiveWe estimated the effects of SSB consumption on semen quality in a North American preconception cohort study.MethodsWe analyzed baseline data from 690 males (n = 1
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Application of the sexual therapy combined with vacuum negative pressure hydropneumatic/pneumatic bubble massage in primary intravaginal anejaculation Andrology (IF 4.5) Pub Date : 2024-03-05 Qingqiang Gao, Jianhuai Chen, Bin Wang, Youfeng Hang, Songzhan Gao, Jie Yang, Yutian Dai
IntroductionPrimary intravaginal anejaculation (PIAJ) is a relatively uncommon male sexual dysfunction characterized by an inability to achieve intravaginal ejaculation during all sexual intercourse. Effective treatment options for this condition are lacking. We aimed to explore the clinical effect of the sexual therapy combined with vacuum negative pressure hydropneumatic/pneumatic bubble massage
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The association of socioeconomic status with semen parameters in a cohort of men in the United States Andrology (IF 4.5) Pub Date : 2024-03-04 Jad Badreddine, Nicholas Sellke, Stephen Rhodes, Nannan Thirumavalavan, Ramy Abou Ghayda
BackgroundSocioeconomic differences are present within the population of men who experience infertility and seek treatment.ObjectiveTo study the association of socioeconomic status with semen parameters in a group of men using mail‐in semen analyses.Materials and methodsThe records of 11,134 men that used mail‐in semen analyses from a fertility company were identified. Their demographic information
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The neurological decline and psychological factors caused by coronavirus disease 2019 may be predictors of erectile dysfunction Andrology (IF 4.5) Pub Date : 2024-03-04 Yukuai Ma, Tianle Zhu, Peng Yang, Rui Gao, Lanhui Shen, Pan Gao, Jingjing Gao, Xi Liu, Hui Jiang, Xiansheng Zhang
BackgroundSince the outbreak of coronavirus disease 2019, it has had a serious impact on people's physical and mental health. However, in our clinical work, we have found that the erectile function of coronavirus disease 2019 patients with neurological decline was often seriously affected.ObjectivesTo further explore the relationship between erectile dysfunction and neurological dysfunction caused
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Physiological role of potassium channels in mammalian germ cell differentiation, maturation, and capacitation Andrology (IF 4.5) Pub Date : 2024-03-04 Ariadna Delgado‐Bermúdez, Marc Yeste, Sergi Bonet, Elisabeth Pinart
BackgroundIon channels are essential for differentiation and maturation of germ cells, and even for fertilization in mammals. Different types of potassium channels have been identified, which are grouped into voltage‐gated channels (Kv), ligand‐gated channels (Kligand), inwardly rectifying channels (Kir), and tandem pore domain channels (K2P).Material‐MethodsThe present review includes recent findings
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Metastasis‐associated protein 1 participates in regulating luminal acidification of the epididymis via repressing estrogen receptor alpha transcription Andrology (IF 4.5) Pub Date : 2024-03-04 Pang Cheng, Jinhua Wei, Bo Liu, Ya Zhao, Binfang Ma, Xiao Feng, Mingxiang Xiong, Jie Zhao, Changhong Shi, Zhen Li
BackgroundAs a component of the nucleosome remodeling and deacetylating (NuRD) complex, metastasis‐associated protein 1 (MTA1) has been reported to be abundant in male reproductive system and might participate in spermatogenesis and sperm maturation, whereas the precise functional role of MTA1 in these processes is still undetermined.ObjectiveTo investigate the effect and potential function of MTA1
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Real‐life users of hormonal or thermal male contraception: An analysis of female partners’ motivation, experience, and satisfaction Andrology (IF 4.5) Pub Date : 2024-02-29 Clothilde Laurent, Roger Mieusset, Jean‐Claude Soufir, Jeanne Perrin
BackgroundTwo male contraceptive methods that inhibit spermatogenesis currently exist: thermal male contraception and hormonal male contraception. Only five studies have been conducted on the acceptability of these methods among men; among women, only the hypothetical acceptability of such a male contraceptive approach as the sole contraception method used by a couple has been evaluated.ObjectivesTo
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Evaluating the impact of pre‐diagnostic use of statins and testosterone replacement therapy on mortality outcomes in older men with hormone‐related cancers: Surveillance, Epidemiology, and End Results‐Medicare 2007–2015 Andrology (IF 4.5) Pub Date : 2024-02-29 Maryam R. Hussain, Omer Abdelgadir, Efstathia Polychronopoulou, Konstantinos K. Tsilidis, Laith Alzweri, Alejandro Villasante‐Tezanos, Jacques Baillargeon, Steven Canfield, Yong‐Fang Kuo, David S. Lopez
BackgroundThe link between the pre‐diagnostic use of statins and testosterone replacement therapy and their impact on hormone‐related cancers, prostate cancer, colorectal cancer, and male breast cancer survival remains a topic of controversy. Further, there is a knowledge gap concerning the joint effects of statins and testosterone replacement therapy on hormone‐related cancer survival outcomes.ObjectiveTo
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A detection model of testis‐derived circular RNAs in serum for predicting testicular sperm retrieval rate in non‐obstructive azoospermia patients Andrology (IF 4.5) Pub Date : 2024-02-29 Mo‐qi Lv, Yan‐qi Yang, Yi‐Xin Li, Liang Zhou, Pan Ge, Rui‐fang Sun, Jian Zhang, Jun‐cheng Gao, Liu‐qing Qu, Qi‐ya Jing, Pin‐cheng Li, Yu‐jia Yan, Hai‐xu Wang, He‐cheng Li, Dang‐xia Zhou
BackgroundMicrodissection testicular sperm extraction is an effective method to retrieve sperm from non‐obstructive azoospermia patients. However, its successful rate is less than 50%.ObjectivesTo identify the predictive value of circular RNAs in serum for sperm retrieval rate in non‐obstructive azoospermia patients.Materials and methods180 non‐obstructive azoospermia patients were recruited in this
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Transgenerational effects of paternal exposures: the role of germline de novo mutations Andrology (IF 4.5) Pub Date : 2024-02-23 Hojat Dehghanbanadaki, Masaya Jimbo, Kiarad Fendereski, Jason Kunisaki, Joshua J Horns, Joemy M. Ramsay, Kelli X. Gross, Alexander W. Pastuszak, James M. Hotaling
Germline de novo mutations (DNMs) refer to spontaneous mutations arising during gametogenesis, resulting in genetic changes within germ cells that are subsequently transmitted to the next generation. While the impact of maternal exposures on germline DNMs has been extensively studied, more recent studies have begun to highlight the increasing importance of the effects of paternal factors. In this review
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Serum total testosterone is associated with phosphate and calcium excretion in response to oral phosphate loading in healthy middle-aged males Andrology (IF 4.5) Pub Date : 2024-02-20 Jaya K. Sharma, Mandy E. Turner, Amanda S. Paynter, Patrick A. Norman, Christine A. White, Emilie C. Ward, Michael A. Adams, Rachel M. Holden
Androgen receptors are expressed in the kidney and serum testosterone is negatively associated with serum phosphate in males, suggesting a role of testosterone in renal phosphate handling. In this cross-sectional study, we examined the association of serum total and free testosterone with acute phosphate and calcium excretion in males in response to an oral phosphate challenge. Thirty-five healthy
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Whole‐exome sequencing identifies ADGB as a novel causative gene for male infertility in humans: from motility to fertilization Andrology (IF 4.5) Pub Date : 2024-02-22 Yang Gao, Liting Liu, Shixiong Tian, Chunyu Liu, Mingrong Lv, Huan Wu, Dongdong Tang, Bing Song, Qunshan Shen, Yuping Xu, Ping Zhou, Zhaolian Wei, Feng Zhang, Yunxia Cao, Xiaojin He
ObjectivesIn male mice, adgb‐knockout has been reported to cause male infertility with spermatogenesis defects involving flagella and acrosome. However, this remains unclear for humans.Materials and methodsSequencing studies were conducted in a research hospital on samples from three unrelated infertile men with severe asthenoteratozoospermia from Han Chinese families. Data were collected through rigorous
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EHMT2/G9a and EZH2: Epimarkers in testicular germ cell tumors Andrology (IF 4.5) Pub Date : 2024-02-21 Helena Estevão‐Pereira, Catarina Guimarães‐Teixeira, Bianca C. T. Flores, Filipa Moreira‐Silva, Nuno Tiago Tavares, Rita Guimarães, Isaac Braga, Joaquina Maurício, Rui Henrique, Carmen Jerónimo, João Lobo
BackgroundTesticular germ cell tumors remain the most frequent solid malignancies in young males. Despite excellent prognosis, the fact that only 60% of patients at diagnosis have elevated serum tumor markers (dependent on stage and histology) and the poor quality of life of patients who develop resistance to chemotherapy cannot be neglected. Consequently, it is mandatory to bring out novel biomarkers
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Testicular biopsies in men with testicular microlithiasis and additional risk factors for cancer: A case series Andrology (IF 4.5) Pub Date : 2024-02-20 Rasmus Hassing Frandsen, Emil Durukan, Elena von Rohden, Christian Fuglesang S. Jensen, Andreas Key Milan Thamsborg, Nessn Azawi, Mikkel Fode
BackgroundTesticular microlithiasis is the presence of small calcifications in the testicular parenchyma. The association between testicular microlithiasis and germ cell neoplasia in situ, a precursor to testicular cancer, is still unclear.ObjectivesTo determine the incidence of germ cell neoplasia in situ in men with testicular microlithiasis and evaluate the indication for testicular biopsy according
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Is varicocoelectomy indicated in infertile men with isolated teratozoospermia? a systematic review and meta-analysis Andrology (IF 4.5) Pub Date : 2024-02-12 Murat Dursun, Hüseyin Beşiroğlu, Reşat Aydın, Turgay Kaçan, Ahmet Halil Sevinç, Ateş Kadıoğlu
Clinical palpable varicocoeles in conjunction with isolated teratozoospermia are rarely observed. Therefore, the effects of varicocoelectomy on sperm morphology are not clear. The aim of this meta-analysis is to compile studies that assess the effectiveness of varicocoelectomy in isolated teratozoospermia to reach a more consistent and reliable conclusion.
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The paternal role in pregnancy loss Andrology (IF 4.5) Pub Date : 2024-02-09 Wade Muncey, Michael Scott, Ruth B. Lathi, Michael L. Eisenberg
In this comprehensive review, the intricate relationship between paternal factors and pregnancy loss is examined. While pregnancy loss has historically been predominantly attributed to maternal factors, recent research underscores the significant contribution of the male partner. The review delves into various aspects of paternal influence, including paternal age, health, chromosome abnormalities,
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The association between ambient temperature and semen quality in a Northern Peninsular Province, China Andrology (IF 4.5) Pub Date : 2024-01-30 Li Wang, Yinan Qu, Wenkai Han, Meng Cai, Wei Ma, Qi Zhao, Zi-Jiang Chen
Extreme ambient temperature has been linked to decline in males’ semen quality. Although the temperature–semen quality association has been examined in certain cities of South China, how the effect size of the extreme temperature may lag over critical windows in spermatogenesis and whether the strength of association may vary in North China have yet been adequately explored.
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3-Hydroxy-3-methylglutaryl-CoA synthase 2 facilitates erectile dysfunction via inhibiting autophagy by enhancing the mammalian target of rapamycin pathway in type 1 diabetic mellitus rats Andrology (IF 4.5) Pub Date : 2024-01-25 Zhiqiang Dai, Yang Zeng, Xiao Tan, Tao Zhou, Xiong Li, Qingfu Deng
The relationship between erectile dysfunction (ED) and type 1 diabetes mellitus (T1DM) is currently a hot topic of medical research. It has been reported that autophagy plays a crucial role in causing erectile dysfunction in T1DM. Recent research has shown that mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) is strongly linked to the development of T1DM. However, the specific mechanism
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Novel variations in TENT5D lead to teratozoospermia in infertile patients Andrology (IF 4.5) Pub Date : 2024-01-16 Ying-Teng Zhang, Gan Shen, Liang-Chai Zhuo, Xue Yang, Su-Yan Wang, Tie-Chao Ruan, Chuan Jiang, Xiang Wang, Yan Wang, Yi-Hong Yang, Ying Shen
Teratozoospermia is the main pathogenic factor of male infertility. However, the genetic etiology of teratozoospermia is largely unknown. This study aims to clarify the relationship between novel variations in TENT5D and teratozoospermia in infertile patients.
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A global perspective: characteristics of infertility-related randomized clinical trials Andrology (IF 4.5) Pub Date : 2024-01-17 Yu Xi, Ya-Lei Cao, Li-Yuan Tao, Song-Zhan Gao, Zi-Run Jin, Jian-Xing Cheng, Hui Jiang, Zhe Zhang
Infertility is a prevalent global condition, and emerging reproductive technologies may enhance its evaluation and treatment. Understanding the current features of randomized clinical trials in infertility is crucial for improving study design and ensuring the translation of results for patient benefits.
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Heme-induced corpus cavernosum relaxation and its implications for priapism in sickle cell disease: a mechanistic insight Andrology (IF 4.5) Pub Date : 2024-01-17 Dalila Andrade Pereira, Danillo Andrade Pereira, Tammyris Helena Rebecchi Silveira, Fabiano Beraldi Calmasini, Arthur L. Burnett, Fernando Ferreira Costa, Fábio Henrique Silva
Patients with sickle cell disease (SCD) experience intravascular hemolysis, leading to elevated plasma heme levels. This phenomenon has been associated with increased priapism in men with SCD. The heme group can be metabolized by heme oxygenase (HO), generating carbon monoxide (CO), which is known to promote smooth muscle relaxation via soluble guanylyl cyclase (sGC)–cyclic guanosine monophosphate
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Repetitive transcranial magnetic stimulation via the hippocampal brain-derived neurotrophic factor–tyrosine kinase receptor B pathway to affect sexual behavior and neuroplasticity in rapid ejaculation rats Andrology (IF 4.5) Pub Date : 2024-01-17 Qiushi Liu, Ming Wang, Weinan Wang, Shaoyu Yue, Tommaso B. Jannini, Emmanuele A. Jannini, Hui Jiang, Xiansheng Zhang
Premature ejaculation (PE) is the most prevalent sexual dysfunction among men. Eejaculation involves a complex nervous mechanism in which the ejaculatory centers play a key role in modulating sperm emission. Although treatment possibilities span from psychotherapy to pharmacological approaches, results show inconsistent efficacy. In this context, the emergence of repetitive transcranial magnetic stimulation
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Trends in the use of testicular prostheses in Germany: a total population analysis from 2006–2021 Andrology (IF 4.5) Pub Date : 2024-01-16 Cem Aksoy, Philipp Reimold, Philipp Karschuck, Christer Groeben, Rainer Koch, Nicole Eisenmenger, Smita Thoduka, Aristeidis Zacharis, Hans Schmelz, Johannes Huber, Luka Flegar
Testicular tumors are the most common malignancies in young adults and their incidence is growing. The implantation of a testicular prosthesis, for example, during orchiectomy is a standard procedure but its frequency in Germany is unknown. This study aims to analyze trends of testicular prosthesis implantation in recent years in Germany.
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New insights into sperm physiology regulation: Enlightenment from G-protein-coupled receptors Andrology (IF 4.5) Pub Date : 2024-01-15 Pengyuan Dai, Chen Chen, Jingyan Yu, Chaoye Ma, Xiaoning Zhang
G-protein-coupled receptors are critical in many physiological and pathological processes in various organs. Serving as the control panel for sensing extracellular stimuli, G-protein-coupled receptors recognise various ligands, including light, temperature, odours, pheromones, hormones, neurotransmitters, chemokines, etc. Most recently, G-protein-coupled receptors residing in spermatozoa have been
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Cost-effectiveness of testosterone treatment utilising individual patient data from randomised controlled trials in men with low testosterone levels Andrology (IF 4.5) Pub Date : 2024-01-17 Rodolfo Hernández, Nipun Lakshitha de Silva, Jemma Hudson, Moira Cruickshank, Richard Quinton, Paul Manson, Waljit S. Dhillo, Siladitya Bhattacharya, Miriam Brazzelli, Channa N. Jayasena
Testosterone is safe and highly effective in men with organic hypogonadism, but worldwide testosterone prescribing has recently shifted towards middle-aged and older men, mostly with low testosterone related to age, diabetes and obesity, for whom there is less established evidence of clinical safety and benefit. The value of testosterone treatment in middle-aged and older men with low testosterone
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Impact of sexual function domains on sexual satisfaction and quality of life: Importance across the age spectrum Andrology (IF 4.5) Pub Date : 2024-01-16 Jackson J. Cabo, Melissa R. Kaufman, Niels V. Johnsen
Sexual satisfaction is an important component of global quality life for many adult men. Substantial gaps exist in our appreciation of how age mediates sexual satisfaction in the context of functional sexual measures. We sought to evaluate modifiable factors associated with overall sexual satisfaction and health-related quality of life (HRQoL) in a large, age-stratified community-based sample of adult
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Comparative analysis of surgical modalities for the gynecomastia treatment: efficiency and aesthetic outcomes Andrology (IF 4.5) Pub Date : 2024-01-16 Debo Chen, Jialin Chen, Yiqin Huang, Chengye Hong, Liangqiang Li, Bimei Cai, Zhipeng Hong
This retrospective study rigorously compares the clinical efficacy of three surgical methodologies for treating gynecomastia while providing guidance for future surgical modality selection. We analyzed records of 77 gynecomastia patients treated between January 2015 and October 2022. Patients were categorized into three groups: Group A (subcutaneous gland resection via areola incision), Group B (liposuction
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MiRNA-100 ameliorates diabetes mellitus-induced erectile dysfunction by modulating autophagy, anti-inflammatory, and antifibrotic effects Andrology (IF 4.5) Pub Date : 2024-01-16 Beining Li, Peng Hu, Kang Liu, Wenchao Xu, Jiaxin Wang, Qinyu Li, Bingliang Chen, Yuxuan Deng, Chenglin Han, Taotao Sun, Xinqi Liu, Mingchao Li, Tao Wang, Jihong Liu, Huang Lin, Ke Rao
Diabetes mellitus-induced erectile dysfunction (DMED) has become a common disease in adult men that can seriously reduce the quality of life of patients, and new therapies are urgently needed. miRNA-100 has many targets and can induce autophagy and reduce fibrosis by inhibiting the mTOR pathway and the TGF-β pathway. However, no research has been conducted with miR-100 in the field of DMED, and the
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Sperm selection by zona adhesion improves assisted reproductive treatment outcomes Andrology (IF 4.5) Pub Date : 2024-01-15 Rumiana Ganeva, Dimitar Parvanov, Nina Vidolova, Maria Handzhiyska, Margarita Ruseva, Magdaleva Vasileva, Kristina Nikolova, Ivka Ivanova, Miray Shaban, Joanna Shabarkova, Rayna Hristova, Milena Miladinova, Georgi Stamenov
Zona pellucida is one of the main selective barriers for the spermatozoa before reaching the oocyte. Using native zona in the sperm selection prior to Intracytoplasmic Sperm Injection (ICSI) has been proven effective but inconvenient approach in In Vitro Fertilisation (IVF) laboratory. The application of autologous solubilised zonae pellucidae in the sperm selection prior to ICSI has not been studied
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An integrated approach for improving clinical management of non-obstructive azoospermia Andrology (IF 4.5) Pub Date : 2024-01-14 Fu Shi, Ye Liu, Zheng Chen, Dongliang Li, Yuanqing Yao, Meixun Zhou, Yumin Zhuo, Xin Ma, Dandan Cao
Non-obstructive azoospermia is the most severe form of male infertility. A testicular biopsy is required for the diagnosis of non-obstructive azoospermia, and the causal factors for non-obstructive azoospermia remain unknown.
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Knockdown of programmed cell death factor 4 restores erectile function by attenuating apoptosis in rats with bilateral cavernous nerve crush injury Andrology (IF 4.5) Pub Date : 2024-01-13 Yunlong Ge, Tian Xia, Zejia Feng, Yuhang Xi, Daoyuan Hu, Yude Hong, Bowen Tang, Jianjie Wu, Jialiang Chen, Hengjun Xiao
Apoptosis is an important pathologic mechanism of erectile dysfunction after radical prostatectomy. Studies have shown that programmed cell death factor 4 is connected to the modulation of apoptosis in many cells. However, the programmed cell death factor 4 function in the cavernous nerve injury erectile dysfunction is unclear.
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Sex hormones and the total testosterone:estradiol ratio as predictors of severe acute respiratory syndrome coronavirus 2 infection in hospitalized men Andrology (IF 4.5) Pub Date : 2024-01-11 David Ruiz-Ochoa, Armando-Raúl Guerra-Ruiz, María-Teresa García-Unzueta, Pedro Muñoz-Cacho, Bryan Rodriguez-Montalvan, Carlos Antonio Amado-Diago, Bernardo-Alio Lavín-Gómez, María-Eliecer Cano-García, Daniel Pablo-Marcos, Luis Alberto Vázquez
The predictive ability of the early determination of sex steroids and the total testosterone:estradiol ratio for the risk of severe coronavirus disease 2019 or the potential existence of a biological gradient in this relationship has not been evaluated.
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The emergence of natural products as potential therapeutics for male infertility Andrology (IF 4.5) Pub Date : 2024-01-08 Xiuyun Li, Bin Zhang, Huijun Yang, Liuping Zhang, Hongxiang Lou, Shicun Zheng
Infertility is a major reproductive health problem. Approximately 50% of all documented cases of infertility are attributable to male factors, such as poor testicular function and semen quality. The recent significant global decline in sperm counts has serious implications for male fertility, but the armamentarium for improving testicular function and semen quality is limited. Natural products have
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Association of abstinence time with semen quality and fertility outcomes: a systematic review and dose–response meta-analysis Andrology (IF 4.5) Pub Date : 2024-01-10 Chengchao Du, Yi Li, Chongyang Yin, Xuefeng Luo, Xiangcheng Pan
Infertility affects 186 million people worldwide, with male factors contributing to 50% of infertility cases. Semen analysis is a key for diagnosing male factor infertility, but sperm parameters can be influenced by ejaculatory abstinence (EA) duration. Shortening or prolonging EA can impact on semen quality and assisted reproductive technology (ART) outcomes, but the optimal EA duration remains unclear
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The habits of European urologists in the field of cryopreservation before the urological cancers treatment Andrology (IF 4.5) Pub Date : 2024-01-06 Amandine Degraeve, Thierry Roumeguere, Gilles Tilmans, Marie-Laura Marotta, Eric Huyghe, Georges Fournier, Antoine Faix, Anne-Françoise Spinoit, Karel Decaestecker, François Herve, Florence Boitrelle, Kanerva Lahdensuo, Lorenzo Tosco, Julien Van Damme
Treatments against urogenital cancers frequently have fertility side-effects. The strategy to preserve fertility after oncologic treatments is still a matter of debate with a lack of evidence and international guidelines. The aim of this study is to investigate fertility preservation practices before urogenital cancer treatments and to compare national habits.
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For the penile length—how shall we choose the straightening procedures in hypospadias repair? Andrology (IF 4.5) Pub Date : 2024-01-03 Yan Liang, Yiqing Lyu, Yichen Huang, Min Wu, Xiaoxi Li, Hua Xie, Fang Chen
To define the appropriate penile straightening procedures corresponding to the specific penile curvature by comparing the penile length resulting from various straightening procedures in hypospadias repair.
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6-Nitrodopamine is an endogenous mediator of the rabbit corpus cavernosum relaxation Andrology (IF 4.5) Pub Date : 2023-12-29 Antonio Tiago Lima, José Britto-Júnior, Manoel Odorico Moraes, Maria Elisabete A. Moraes, Adriano Fregonesi, Fabíola Z. Monica, Edson Antunes, Gilberto De Nucci
6-Nitrodopamine (6-ND) is a novel endogenous catecholamine that has a potent relaxant action on vascular smooth muscle in vitro.
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Comparing Western and traditional Chinese medicine for male sexual dysfunction: can Klotho represent a silk road? Andrology (IF 4.5) Pub Date : 2023-12-28 Fu Wang, Elena Colonnello, Hui Zhang, Andrea Sansone, Chunlin Wang, Susanna Dolci, Jun Guo, Emmanuele A. Jannini
Traditional Chinese medicine (TCM) and Western Medicine both have shown efficacy in treating male sexual dysfunction (MSD). The aim of this perspective paper is to discuss a possible link between Western medicine and TCM in the MSD field as represented by the entity of Klotho. Klotho is a recently discovered protein, mainly expressed in the kidney, encoded by the anti-aging gene klotho. Not only is
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Testosterone replacement therapy: association with mortality in high-risk patient subgroups Andrology (IF 4.5) Pub Date : 2023-12-26 Amar Mann, Richard C Strange, Carola S König, Geoffrey Hackett, Ahmad Haider, Karim Sultan Haider, Peter Desnerck, Sudarshan Ramachandran
We describe studies determining the association between testosterone therapy (TTh) and mortality.
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Paternal and maternal preconception and maternal pregnancy urinary concentrations of parabens in relation to child behavior Andrology (IF 4.5) Pub Date : 2023-12-28 Jordana Leader, Lidia Mínguez-Alarcón, Paige L. Williams, Jennifer B. Ford, Ramace Dadd, Olivia Chagnon, David C. Bellinger, Emily Oken, Antonia M. Calafat, Russ Hauser, Joseph M. Braun
Epidemiologic studies of the effects of parental preconception paraben exposures on child behavior are limited despite emerging evidence suggesting that such exposures may affect offspring neurodevelopment.
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Microfluidics: The future of sperm selection in assisted reproduction Andrology (IF 4.5) Pub Date : 2023-12-26 Ali Reza Jahangiri, Niloofar Ziarati, Ehsan Dadkhah, Mustafa Numan Bucak, Pegah Rahimizadeh, Abdolhossein Shahverdi, Mohammad Ali Sadighi Gilani, Tohid Rezaei Topraggaleh
Obtaining functional sperm cells is the first step to treat infertility. With the ever-increasing trend in male infertility, clinicians require access to effective solutions that are able to single out the most viable spermatozoa, which would max out the chance for a successful pregnancy. The new generation techniques for sperm selection involve microfluidics, which offers laminar flow and low Reynolds
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Cryopreservation of highly extended pig spermatozoa remodels its proteome and counteracts polyspermic fertilization in vitro Andrology (IF 4.5) Pub Date : 2023-12-22 Inmaculada Parrilla, Josep M. Cambra, Cristina Cuello, Heriberto Rodriguez-Martinez, Maria A. Gil, Emilio A. Martinez
Currently, high polyspermy remains a significant obstacle to achieving optimal efficiency in in vitro fertilization (IVF) and in vitro embryo production (IVP) systems in pigs. Developing strategies that would prevent polyspermy is essential in overcoming this challenge and maximizing the potential of this reproductive biotechnology. Previous results have demonstrated that using boar spermatozoa subjected
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Time for the bi-annual rotation in the Editorial Team of Andrology. Thanks to Marie-Claude Hofmann and welcome to Wei Yan Andrology (IF 4.5) Pub Date : 2023-12-19 Aleksander Giwercman
Dear Colleagues The start of an even calendar year also marks the bi-annual rotation of Andrology's editorial team. Thus, after 2 years (2021-2022) as Deputy Editor (DE) and additional 2 years (2022-2023) as Editor-in-Chief (EIC) Professor Marie-Claude Hofmann will step down. Aleksander Giwercman will become the new EIC and will be replaced as DE by Professor Wei Yan. First, we would like to thank
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ICSI using testicular spermatozoa after failure of ICSI with ejaculated spermatozoa could be a good choice: A propensity score-matched cohort study Andrology (IF 4.5) Pub Date : 2023-12-18 Mehdi Benchaib, Elsa Labrune, Sandrine Giscard d'Estaing, Cynthia Jovet, Gaëlle Soignon, Pauline Jaeger, Bruno Salle
Ejaculated spermatozoa are considered to possess a higher fertilisation potential than testicular spermatozoa. In selected cases, the use of testicular spermatozoa from non-azoospermic infertile men resulted in a higher implantation and pregnancy rate than the use of ejaculated spermatozoa.
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The CXCL10/CXCR3 axis regulates Th1 cell differentiation and migration in experimental autoimmune prostatitis through the PI3K/AKT pathway Andrology (IF 4.5) Pub Date : 2023-12-14 Shao-Yu Yue, Di Niu, Wen-Ming Ma, Yu Guan, Qiu-Shi Liu, Xiao-Bin Wang, Yun-Zheng Xiao, Jialin Meng, Ke Ding, Li Zhang, He-Xi Du, Chao-Zhao Liang
To investigate the mechanism of the CXCL10/CXCR3 axis regulating Th1 cell differentiation and migration through the PI3K/AKT pathway in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).
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CRISPR/Cas9-mediated genome editing reveals seven testis-enriched transmembrane glycoproteins dispensable for male fertility in mice Andrology (IF 4.5) Pub Date : 2023-12-12 Yo Ogawa, Yonggang Lu, Daiji Kiyozumi, Hsin-Yi Chang, Masahito Ikawa
Mammalian fertilization is mediated by multiple sperm acrosomal proteins, many of which are testis-enriched transmembrane glycoproteins expressed during spermiogenesis (e.g., Izumo sperm-egg fusion 1, Sperm acrosome associated 6, and Transmembrane protein 95).
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Genome sequencing of Pakistani families with male infertility identifies deleterious genotypes in SPAG6, CCDC9, TKTL1, TUBA3C, and M1AP Andrology (IF 4.5) Pub Date : 2023-12-10 Muhammad Riaz Khan, Arvand Akbari, Thomas J. Nicholas, Helen Castillo-Madeen, Muhammad Ajmal, Taqweem Ul Haq, Maris Laan, Aaron R. Quinlan, Jasvinder S. Ahuja, Aftab Ali Shah, Donald F. Conrad
There are likely to be hundreds of monogenic forms of human male infertility. Whole genome sequencing (WGS) is the most efficient way to make progress in mapping the causative genetic variants, and ultimately improve clinical management of the disease in each patient. Recruitment of consanguineous families is an effective approach to ascertain the genetic forms of many diseases.
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Alterations in sperm RNAs persist after alcohol cessation and correlate with epididymal mitochondrial dysfunction Andrology (IF 4.5) Pub Date : 2023-12-03 Alexis N. Roach, Sanat S. Bhadsavle, Samantha L. Higgins, Destani D. Derrico, Alison Basel, Kara N. Thomas, Michael C. Golding
Chronic preconception paternal alcohol use adversely modifies the sperm epigenome, inducing fetoplacental and craniofacial growth defects in the offspring of exposed males. A crucial outstanding question in the field of paternal epigenetic inheritance concerns the resilience of the male germline and its capacity to recover and correct sperm-inherited epigenetic errors after stressor withdrawal.
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Aging of stallion spermatozoa stored in vitro is delayed at 22°C using a 67 mm glucose–10 mm pyruvate-based media Andrology (IF 4.5) Pub Date : 2023-12-01 Laura Becerro-Rey, Francisco Eduardo Martín-Cano, Cristina Ortega Ferrusola, Heriberto Rodríguez-Martínez, Gemma Gaitskell-Phillips, Eva da Silva-Álvarez, Antonio Silva-Rodríguez, María Cruz Gil, Fernando J. Peña
Most commerce of equine seminal doses is carried out using commercial extenders under refrigeration at 5°C.