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Primary aldosteronism patients with previous cardiovascular and cerebrovascular events have high aldosterone responsiveness to ACTH stimulation Endocr. J. (IF 2.0) Pub Date : 2024-03-14 Eriko Nakano, Kosuke Mukai, Atsunori Fukuhara, Michio Otsuki, Iichiro Shimomura, Takamasa Ichijo, Mika Tsuiki, Norio Wada, Takashi Yoneda, Yoshiyu Takeda, Kenji Oki, Tetsuya Yamada, Yoshihiro Ogawa, Daisuke Yabe, Miki Kakutani, Masakatsu Sone, Takuyuki Katabami, Akiyo Tanabe, Mitsuhide Naruse, JPAS/JRAS Study Group
Aldosterone secretion in primary aldosteronism (PA) is often regulated by adrenocorticotropic hormone (ACTH) in addition to its autonomous secretion. However, the clinical characteristics and risk of cardiovascular and cerebrovascular (CCV) events in PA patients with aldosterone responsiveness to ACTH stimulation remain unclear. This study aimed to investigate the prevalence of CCV events in PA patients
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Impact of coronavirus disease 2019 on medical practice in endocrine and metabolic diseases in Japan: a nationwide surveillance study conducted by the Japan Endocrine Society Endocr. J. (IF 2.0) Pub Date : 2024-03-09 Katsunori Manaka, Sayaka Kato, Ryuichi Sakamoto, Hajime Yamakage, Tsugumi Uema, Shiori Kawai, Megumi Shibata, Izumi Hiratsuka, Sawako Nakachi, Takeshi Onoue, Takefumi Tsuchiya, Michiaki Fukui, Koshi Hashimoto, Atsushi Suzuki, Noriko Makita, Yoshihiro Ogawa, Hiroshi Arima, Noriko Satoh-Asahara, Hiroaki Masuzaki
We investigated the impact of the Coronavirus disease 2019 (COVID-19) pandemic on the management of endocrine and metabolic disorders in Japan. We conducted a cross-sectional nationwide questionnaire survey targeting board-certified endocrinologists under the auspices of the Japan Endocrine Society. The questionnaire consisted of multiple-choice questions and open-ended responses. Out of approximately
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Clinical and molecular analyses of isolated central congenital hypothyroidism based on a survey conducted in Japan Endocr. J. (IF 2.0) Pub Date : 2024-03-08 Nao Shibata, Chikahiko Numakura, Takashi Hamajima, Kenichi Miyako, Ikuma Fujiwara, Jun Mori, Akihiko Saitoh, Keisuke Nagasaki
Central congenital hypothyroidism (CH) can occur as an isolated deficiency or as part of combined pituitary hormone deficiency. Unlike primary CH, central CH cannot be detected by newborn screening (NBS) using dry filter paper blood TSH levels, and early diagnosis remains challenging. In this study, the clinical and genetic backgrounds of patients with isolated central CH were determined through a
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Clinical findings of acute necrotizing esophagitis complicated by diabetic ketoacidosis Endocr. J. (IF 2.0) Pub Date : 2024-03-07 Yuichiro Iwamoto, Tomohiko Kimura, Takashi Itoh, Shigehito Mori, Taku Sasaki, Mana Ohnishi, Haruka Takenouchi, Hideyuki Iwamoto, Junpei Sanada, Yoshiro Fushimi, Yukino Katakura, Fuminori Tatsumi, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
Acute necrotizing esophagitis (ANE) is a rare and potentially life-threatening complication of diabetic ketoacidosis (DKA). While its association with DKA is established, specific clinical characteristics that predict ANE in DKA patients remain less understood. This study aimed to identify these characteristics by analyzing data from 30 DKA patients admitted from January 2018 to September 2022. Seven
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Brown fat thermogenesis and branched-chain amino acids in metabolic disease Endocr. J. (IF 2.0) Pub Date : 2024-02-28 Zachary Brown, Takeshi Yoneshiro
Since the 1960s, researchers have recognized an association between elevated plasma branched chain amino acids (BCAA) and metabolic disease, including type 2 diabetes mellitus and obesity, but the cause for it remained poorly understood. Recent advances in metabolomics, advanced imaging techniques, and genetic analyses over the past decade have enabled newfound insights into the mechanism of BCAA metabolic
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Single-cell and spatial transcriptomics in endocrine research Endocr. J. (IF 2.0) Pub Date : 2024-02-28 Ryusaku Matsumoto, Takuya Yamamoto
Accumulating evidence suggests that cellular heterogeneity in organs and cell-cell and tissue-tissue interactions are crucial for maintaining physical homeostasis and disease progression. Endocrine organs also exhibit cellular heterogeneity and comprise multiple cell types. For instance, the pituitary gland comprises five types of pituitary hormone-producing cells as well as non-hormone-producing supporting
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Effects of plant- and animal-based-protein meals for a day on serum nitric oxide and peroxynitrite levels in healthy young men Endocr. J. (IF 2.0) Pub Date : 2024-02-28 Tomoko Kaneko, Masaki Yoshioka, Futo Kawahara, Natsumi Nishitani, Shoya Mori, Jiyeon Park, Takashi Tarumi, Keisei Kosaki, Seiji Maeda
Plant-based diets that replace animal-based proteins with plant-based proteins have received increased attention for cardiovascular protection. Nitric oxide (NO) plays an essential role in the maintenance of endothelial function. However, under higher oxidative stress, NO generation produces peroxynitrite, a powerful oxidant and vasoconstrictor. Diet-replaced protein sources has been reported to decrease
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Ankle reflex and neurological symptom score: a primary level screening method for diabetic peripheral neuropathy Endocr. J. (IF 2.0) Pub Date : 2024-02-28 Xueya Ma, Mengyuan Li, Hui Xie, Ting Sun, Liang Lu, Sumei Li, Yining Sun, Zuchang Ma
Herein, we aimed to develop an easily available and efficient screening method for diabetic peripheral neuropathy (DPN) suitable for primary care settings, emphasizing simplicity, speed, and accuracy. Nerve conduction studies were conducted on 214 patients with diabetes, encompassing the outcomes of five distinct assessments: diabetic neuropathy symptom (DNS), vibration perception threshold (VPT),
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Effects of laparoscopic sleeve gastrectomy on nonalcoholic fatty liver disease and TGF-β signaling pathway Endocr. J. (IF 2.0) Pub Date : 2024-02-28 Hideki Kumagai, Akira Sasaki, Akira Umemura, Keisuke Kakisaka, Takeshi Iwaya, Satoshi S Nishizuka
Nonalcoholic fatty liver disease (NAFLD) develops as a result of unhealthy lifestyle but improves with laparoscopic sleeve gastrectomy (LSG). The transforming growth factor (TGF)-β signaling pathway reportedly contributes to liver fibrosis, mainly in animal experiments. The aim of the present study was to evaluate changes in serum proteins before and after LSG by proteomic analysis and to investigate
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Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men Endocr. J. (IF 2.0) Pub Date : 2024-02-28 Shintaro Yamaguchi, Junichiro Irie, Masanori Mitsuishi, Yuichi Uchino, Hideaki Nakaya, Ryo Takemura, Emi Inagaki, Shotaro Kosugi, Hideyuki Okano, Masato Yasui, Kazuo Tsubota, Kaori Hayashi, Jun Yoshino, Hiroshi Itoh
Obesity and aging are major risk factors for several life-threatening diseases. Accumulating evidence from both rodents and humans suggests that the levels of nicotinamide adenine dinucleotide (NAD+), a regulator of many biological processes, declines in multiple organs and tissues with aging and obesity. Administration of an NAD+ intermediate, nicotinamide mononucleotide (NMN), replenishes intracellular
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Association between screen time, including that for smartphones, and overweight/obesity among children in Japan: NICE EVIDENCE Study 4 Endocr. J. (IF 2.0) Pub Date : 2024-02-28 Izumi Ikeda, Kazuya Fujihara, Sakiko Morikawa Yoshizawa, Yasunaga Takeda, Hajime Ishiguro, Mayuko Yamada Harada, Chika Horikawa, Yasuhiro Matsubayashi, Takaho Yamada, Yohei Ogawa, Hirohito Sone
The association between screen time (ST), including that for smartphones, and overweight/obesity in children was examined separately for boys and girls, considering the influence of lifestyle factors. A cross-sectional study was conducted in 2,242 Japanese children (1,278 girls) aged 10–14 years. Overweight/obesity was defined by the International Obesity Task Force. Logistic regression analysis showed
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Amphibian newts as experimental models for studying weight gain after castration Endocr. J. (IF 2.0) Pub Date : 2024-02-28 Mai Takehara, Mitsuki Kyakuno, Kazuko Okamoto, Ichiro Tazawa, Nobuaki Furuno, Megumi Furumitsu, Kazuyoshi Ukena, Takuya Imamura, Takashi Takeuchi, Toshinori Hayashi
Vertebrate animals often exhibit sexual dimorphism in body shape. In mammals, decreases in sex hormones caused by testicular castration can affect body shape and occasionally lead to pathologies such as obesity. Post-castration obesity can also be problematic for the health of companion animals, including non-mammals. In order to understand the mechanism of post-castration obesity in vertebrates other
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Positive association between proinsulin and fatty liver index in people with type 2 diabetes Endocr. J. (IF 2.0) Pub Date : 2024-02-28 Akinobu Nakamura, Aika Miya, Yuka Suzuki, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, So Nagai, Tatsuya Atsumi
The post-hoc study, derived from our previous prospective observational study, investigated the association between fasting serum proinsulin levels and hepatic steatosis in people with type 2 diabetes. The severity of hepatic steatosis was assessed using the fatty liver index. A total of 268 participants were divided into three groups: low (n = 110), moderate (n = 75), and high fatty liver index (n
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Inhibitory effects of estetrol on the invasion and migration of immortalized human endometrial stromal cells Endocr. J. (IF 2.0) Pub Date : 2024-02-28 Akihiko Wakatsuki, Yinzhi Lin, Shiori Kojima, Hiroshi Matsushita, Kosei Takeuchi, Kazuo Umezawa
Endometriosis, a common gynecological disorder characterized by the growth of endometrial gland and stroma outside the uterus, causes several symptoms such as dysmenorrhea, hypermenorrhea, and chronic abdominal pain. 17β estradiol (E2) stimulates the growth of endometriotic lesions. Although estetrol (E4), produced by human fetal liver, is also a natural estrogen, it may have the opposite effects on
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Expression of SMADs in orthotopic human endometrium, ovarian endometriosis, and endometriotic lesions in a murine model Endocr. J. (IF 2.0) Pub Date : 2024-02-28 Yuri Kadota, Takeshi Kato, Kana Kasai, Takako Kawakita, Misaki Murayama, Akari Shinya, Hikari Sasada, Sachiko Katayama, Mari Nii, Shota Yamamoto, Hiroki Noguchi, Kou Tamura, Hidenori Aoki, Miyu Taniguchi, Tomotaka Nakagawa, Takashi Kaji, Masato Nishimura, Riyo Kinouchi, Kanako Yoshida, Takeshi Iwasa
Activin A promotes the development of endometriotic lesions in a murine model of endometriosis, and the immunohistochemical localization of phosphorylated suppressor of mothers against decapentaplegic homolog 2/3 (pSMAD2/3) complex in endometriotic lesions has been reported. Activin may therefore be involved in the development and proliferation of endometriotic cells via the SMAD signaling pathway
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Adrenal venous sampling criteria for chemiluminescent enzyme immunoassay as a preferable alternative to radioimmunoassay in primary aldosteronism Endocr. J. (IF 2.0) Pub Date : 2024-02-28 Kazuki Nakai, Yuya Tsurutani, Koki Irie, Kyoko Teruyama, Sachiko Suematsu, Seishi Matsui, Kohzoh Makita, Jun Saito, Masao Omura, Tetsuo Nishikawa
Plasma aldosterone concentration (PAC) was routinely measured using radioimmunoassay (RIA); however, the RIA kit was discontinued in March 2021 in Japan. This study examined PAC conversion in adrenal venous sampling (AVS) and AVS criteria when measured using chemiluminescent enzyme immunoassay (CLEIA). PAC of 415 adrenal venous blood samples from AVS (including segmental AVS) of 63 patients with primary
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Positive association between the proinsulin-to-C-peptide ratio and prolonged hyperglycemic time in type 2 diabetes Endocr. J. (IF 2.0) Pub Date : 2024-02-23 Aika Miya, Akinobu Nakamura, Hiroshi Nomoto, Hiraku Kameda, Tatsuya Atsumi
The proinsulin-to-C-peptide (PI:C) ratio is an index applied during the early stage of pancreatic β-cell dysfunction. The aim of this study was to identify the characteristics associated with the PI:C ratio to discuss pancreatic β-cell dysfunction progression during the natural course of type 2 diabetes and its relationship with glycemic management. This multicenter, prospective observational study
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Prevalence of thyroid diffuse goiter and its association with body mass index and the presence of cysts and nodules in children and adolescents: the Fukushima Health Management Survey Endocr. J. (IF 2.0) Pub Date : 2024-02-16 Nana Nakahata, Mahiro Asano, Norikazu Abe, Haruka Ejiri, Hisashi Ota, Satoshi Suzuki, Ayako Sato, Rina Tazaki, Natsuki Nagamine, Chisato Takahashi, Yukie Yamaya, Manabu Iwadate, Takashi Matsuzuka, Tetsuya Ohira, Seiji Yasumura, Satoru Suzuki, Fumihiko Furuya, Hiroki Shimura, Shinichi Suzuki, Susumu Yokoya, Hitoshi Ohto, Kenji Kamiya
The main cause of diffuse thyroid goiter is autoimmune chronic thyroiditis, otherwise known as Hashimoto’s thyroiditis. Thyroid hormones play pivotal roles in growth and development during childhood. However, the prevalence of diffuse goiter and the relationships between diffuse goiter, thyroid volume, cysts and nodules, and anthropometric measurements in children are not well known. Among 789,459
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Lipopolysaccharide inhibits osteoblast formation and receptor activator of nuclear factor-κB ligand degradation via autophagy inhibition Endocr. J. (IF 2.0) Pub Date : 2024-02-14 Huaizhi Zhang, Jianhua Lin, Xu Chen, Jianhui Dai, Haibin Lin
Lipopolysaccharide (LPS) and Receptor Activator of Nuclear Factor-κB Ligand (RANKL) are the two important factors causing bone loss, which is an important pathogenesis for osteoporosis. However, the relationship between LPS and RANKL is not yet clear. LPS can be involved in the weakened osteoblast formation as an autophagy regulator, and osteoblasts and their precursors are the source cells for RANKL
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The effect of soy isoflavones in brain development: the emerging role of multiple signaling pathways and future perspectives Endocr. J. (IF 2.0) Pub Date : 2024-02-10 Winda Ariyani, Noriyuki Koibuchi
Soybean is a source of protein, fibers, and phytochemical isoflavones which are considered to have numerous health benefits for children and adulthood. On the other hand, isoflavones are widely known as phytoestrogens that exert their action via the estrogen signaling pathway. With this regard, isoflavones are also considered as endocrine-disrupting chemicals. Endogenous estrogen plays a crucial role
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Recurrent nocturnal hypoglycemic hemiplegia: a case report and review of the literature Endocr. J. (IF 2.0) Pub Date : 2024-02-09 Hanako Toyama, Kazuyuki Takahashi, Tatsunori Shimizu, Izumi Otaka, Sakiko Abe, Shunsuke Kato, Sayaka Ando, Takehiro Sato, Tsukasa Morii, Hiroki Fujita, Hironori Waki
A 67-year-old man with type 1 diabetes, Cronkhite-Canada syndrome, and membranous nephropathy who received insulin therapy was admitted to our hospital with right hemiplegia and dysarthria. Brain magnetic resonance imaging revealed a lesion with a high diffusion-weighted imaging signal and low apparent diffusion coefficient signal in the posterior limb of the left internal capsule. He was hypoglycemic
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Genetic and biochemical analysis of severe hypertriglyceridemia complicated with acute pancreatitis or with low post-heparin lipoprotein lipase mass Endocr. J. (IF 2.0) Pub Date : 2024-02-09 Takashi Suzuki, Makoto Kurano, Akari Isono, Takuya Uchino, Yohei Sayama, Honami Tomomitsu, Daiki Mayumi, Ruriko Shibayama, Toru Sekiguchi, Naoki Edo, Kiyoko Uno-Eder, Kenji Uno, Koji Morita, Toshio Ishikawa, Kazuhisa Tsukamoto
Severe hypertriglyceridemia is a pathological condition caused by genetic factors alone or in combination with environmental factors, sometimes leading to acute pancreatitis (AP). In this study, exome sequencing and biochemical analyses were performed in 4 patients with hypertriglyceridemia complicated by obesity or diabetes with a history of AP or decreased post-heparin LPL mass. In a patient with
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Development of the anterior pituitary: diverse lineages of the stem/progenitor cells Endocr. J. (IF 2.0) Pub Date : 2024-02-09 Yukio Kato, Takako Kato
The pituitary gland is endocrine tissue composed of two distinct parts with different origins: the adenohypophysis (adenohypophyseal placode origin) and the neurohypophysis (neuroectoderm origin). Differentiation of endocrine cells in the pituitary gland leads to hormone synthesis, secretion into the capillary network, and transportation to target organs. In 1988, the discovery of the pituitary transcription
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A machine learning approach for predicting treatment response of hyponatremia Endocr. J. (IF 2.0) Pub Date : 2024-02-02 Tamaki Kinoshita, Shintaro Oyama, Daisuke Hagiwara, Yoshinori Azuma, Hiroshi Arima
Hyponatremia leads to severe central nervous system disorders and requires immediate treatment in some cases. However, a rapid increase in serum sodium (s-Na) concentration could cause osmotic demyelination syndrome. To achieve a safety hyponatremia treatment, we develop a prediction model of s-Na concentration using a machine learning. Among the 341 and 47 patients admitted to two tertiary hospitals
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The humanistic and societal impact of obesity in Japan: a targeted literature review Endocr. J. (IF 2.0) Pub Date : 2024-02-03 Wataru Ogawa, Palvi Gupta
Obesity is a focus of Japanese public health policy, due to Japanese individuals’ high susceptibility to weight-related conditions. In contrast to global definitions, obesity is defined as a body-mass-index (BMI) of ≥25 kg/m2 in Japan. Despite public efforts, rates of obesity have not decreased over the past decade. To better understand its societal impact, we examined the economic, quality of life
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Active surveillance for adult low-risk papillary thyroid microcarcinoma—a review focused on the 30-year experience of Kuma Hospital— Endocr. J. (IF 2.0) Pub Date : 2024-01-29 Yasuhiro Ito, Akira Miyauchi, Makoto Fujishima, Masashi Yamamoto, Takahiro Sasaki
Active surveillance (AS) for low-risk papillary thyroid microcarcinoma (PTMC), which was initiated at Kuma Hospital (Kobe, Japan) in 1993 and Cancer Institute Hospital (Tokyo) in 1995, is now gradually being adopted worldwide, and several prospective studies have described the favorable outcomes of PTMC patients who underwent AS. The most important factor predicting PTMC growth is young age, and PTMC
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Clinical impact of proteinuria on renal function and treatment outcomes in patients with radioiodine-refractory thyroid cancer treated with lenvatinib Endocr. J. (IF 2.0) Pub Date : 2024-01-31 Naoki Fukuda, Kazuhisa Toda, Hirotaka Suto, Ryosuke Oki, Xiaofei Wang, Tetsuya Urasaki, Yasuyoshi Sato, Kenji Nakano, Makiko Ono, Junichi Tomomatsu, Hiroki Mitani, Shunji Takahashi
Proteinuria has been described as a major on-target adverse event of lenvatinib, although its long-term impact on renal function and clinical outcomes remains unclear. We conducted a retrospective observational study to assess renal function and prognosis in patients with radioiodine-refractory differentiated thyroid cancer (RR-DTC) receiving lenvatinib. Overall, 70 patients with RR-DTC treated with
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The frequency of mutations in advanced thyroid cancer in Japan: a single-center study Endocr. J. (IF 2.0) Pub Date : 2024-01-29 Soji Toda, Hiroyuki Iwasaki, Yoichiro Okubo, Hiroyuki Hayashi, Mei Kadoya, Hiroyuki Takahashi, Tomoyuki Yokose, Yukihiko Hiroshima, Katsuhiko Masudo
We analyzed the outcomes of genetic testing to study the frequency of mutations in advanced thyroid cancer in Japan. Patients (n = 96) with unresectable or metastatic thyroid carcinoma were included for retrospective chart review. Results of gene panel testing, which was performed between May 2020 and April 2023, were analyzed. The median age of the patients was 73.5 years (range, 17–88); 59 were women
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A more accurate relationship between serum androgen and metabolism among healthy, nonobese, reproductive-age women based on liquid chromatography-tandem mass spectrometry Endocr. J. (IF 2.0) Pub Date : 2024-01-29 Sha Ye, Yepei Huang, Yi Lu, Xiaoyan Li, Meiling Ye, Hongyu Lu, Junhua Shi, Jian Huang, Hong Cai
This study explored a more precise association between androgens and glycolipid metabolism in healthy women of different ages. Body mass index (BMI), waist circumference (WC), and waist-to-hip ratio were used as body fat indicators. High-density lipoprotein (HDL), low-density lipoprotein, triglycerides, and total cholesterol were used as lipid markers. Fasting blood glucose (FBG), fasting insulin,
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Composite paraganglioma-ganglioneuroma with atypical catecholamine profile and phenylethanolamine N-methyltransferase expression: a case report and literature review Endocr. J. (IF 2.0) Pub Date : 2024-01-29 Yuriko Sasaki, Maki Kanzawa, Masaaki Yamamoto, Keitaro Kanie, Hironori Bando, Kei Yoshino, Yushi Hirota, Katsumi Shigemura, Masato Fujisawa, Wataru Ogawa, Hidenori Fukuoka
Pheochromocytomas and paragangliomas (PPGLs) are rare tumors that secrete catecholamines and arise from the adrenal medulla or extra-adrenal sympathetic ganglia. These tumors secrete adrenaline and noradrenaline, but paragangliomas usually produce only noradrenaline because of the lack of phenylethanolamine N-methyltransferase (PNMT) expression. Composite paragangliomas, which are complex tumors consisting
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Comparison of pathophysiology in subclinical hyperthyroidism with different etiologies Endocr. J. (IF 2.0) Pub Date : 2024-01-31 Hanna Deguchi-Horiuchi, Mitsuru Ito, Sawako Takahashi, Kazuyoshi Kousaka, Mako Hisakado, Shuji Fukata, Takumi Kudo, Eijun Nishihara, Mitsushige Nishikawa, Akira Miyauchi, Takashi Akamizu
Subclinical hyperthyroidism (SHyper) is defined as normal levels of free thyroxine (fT4) and free triiodothyronine (fT3) with suppressed levels of TSH. Previous studies have reported the individual pathophysiology of endogenous SHyper patients and athyreotic patients receiving TSH suppression therapy with levothyroxine; however, apparently no studies have compared the two conditions. Five-hundred-forty
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Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events Endocr. J. (IF 2.0) Pub Date : 2024-01-29 Tomoko Kobayashi, Shintaro Iwama, Hiroshi Arima
Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs) in several organs including endocrine glands. Among endocrine irAEs, thyroid and pituitary irAEs are frequently observed, followed by primary adrenal insufficiency, insulin-dependent diabetes mellitus, and hypoparathyroidism. These conditions could lead to life-threatening consequences, such as adrenal crisis and diabetic
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Analysis of five cases showing false-high Hemoglobin A1c due to reduced catalase activity Endocr. J. (IF 2.0) Pub Date : 2024-01-29 Kenji Hara, Atsushi Ujiie, Shiori Suzuki, Takenori Okumura, Mio Kubo, Hiroyuki Shinozaki, Mototaka Yamauchi, Takafumi Tsuchiya, Kohzo Takebayashi, Nobuyuki Shimozawa, Masafumi Koga, Koshi Hashimoto
We encountered five cases that exhibited false-high Hemoglobin A1c (HbA1c) levels when samples were examined using the enzyme-based NORUDIA N HbA1c kit. HbA1c levels were higher than those obtained using other methods, such as HPLC, immune-based methods, and other enzyme-based kits. This kit produced inaccurate results for HbA1c when residual peroxides were present in samples. The addition of peroxidase
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Correlation between plasma glutamate and adiponectin in patients with type 2 diabetes Endocr. J. (IF 2.0) Pub Date : 2024-01-29 Hirofumi Nagao, Hitoshi Nishizawa, Shiro Fukuda, Yuya Fujishima, Shunbun Kita, Norikazu Maeda, Takeshi Bamba, Eiichiro Fukusaki, Iichiro Shimomura
Visceral fat accumulation is a major determinant of type 2 diabetes mellitus and cardiovascular diseases. Recent studies have reported that glutamate is the most elevated amino acid in the plasma amino acid profile in patients with obesity and/or visceral fat accumulation. Here, we show the relationship between plasma glutamate and the clinical features of patients with type 2 diabetes. The study subjects
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Sotos syndrome with marked overgrowth in three Japanese patients with heterozygous likely pathogenic NSD1 variants: case reports with review of literature Endocr. J. (IF 2.0) Pub Date : 2024-01-29 Yohei Masunaga, Hiroyuki Ono, Yasuko Fujisawa, Kiyosu Taniguchi, Hirotomo Saitsu, Tsutomu Ogata
We report three Japanese patients with Sotos syndrome accompanied by marked overgrowth, i.e., a 2 8/12-year-old boy with a height of 105.2 cm (+4.4 SD) (patient 1), the mother of patient 1 with a height of 180.8 cm (+4.1 SD) (patient 2), and a 12 10/12-year-old girl with a height of 189.4 cm (+6.3 SD) (patient 3). In addition to the marked overgrowth (tall stature), patients 1–3 exhibited Sotos syndrome-compatible
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Cell-specific functions of androgen receptor in skeletal muscles Endocr. J. (IF 2.0) Pub Date : 2024-01-27 Hiroshi Sakai, Yuuki Imai
Androgens play a vital role not only in promoting the development of male sexual characteristics but also in exerting diverse physiological effects, including the regulation of skeletal muscle growth and function. Given that the effects of androgens are mediated through androgen receptor (AR) binding, an understanding of AR functionality is crucial for comprehending the mechanisms of androgen action
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Secondary vs. primary pituitary xanthogranulomas: Which yellow is more mellow? Endocr. J. (IF 2.0) Pub Date : 2024-01-27 Dragana Miljic, Sandra Pekic, Mirjana Doknic, Marko Stojanovic, Sasa Ilic, Marina Nikolic Djurovic, Zvezdana Jemuovic, Toplica Milojevic, Mihailo Milicevic, Marija Jovanovic, Milica Medic Stojanoska, Bojana Carić, Nevena Radic, Sanja Medenica, Emilija Manojlovic Gacic, Milan Petakov
Pituitary xanthogranulomatomas (XG) are a rare pathological entity caused by accumulation of lipid laden macrophages and reactive granuloma formation usually triggered by cystic fluid leakage or hemorrhage. Our aim was to compare clinical characteristics and presenting features of patients with secondary etiology of XG and those with no identifiable founding lesion (primary -“pure” XG) in order to
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New onset of isolated adrenocorticotropin deficiency associated with encephalopathy following coronavirus disease 2019 in a healthy elderly man Endocr. J. (IF 2.0) Pub Date : 2024-01-20 Yusuke Yamasaki, Ichiro Horie, Riyoko Shigeno, Shinpei Nishikido, Toshiyuki Ikeoka, Takuro Hirayama, Yohei Tateishi, Akira Tsujino, Atsushi Kawakami
Coronavirus disease 2019 (COVID-19) due to a severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can include various systemic organ disorders including endocrinopathies and neurological manifestations. We report the case of a 65-year-old Japanese man who developed isolated adrenocorticotropic hormone (ACTH) deficiency and encephalopathy following SARS-CoV-2 infection. Two weeks after
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Risk factors for mediastinal lymph node metastasis and lung metastasis in papillary thyroid carcinoma patients: who benefits from preoperative computed tomography? Endocr. J. (IF 2.0) Pub Date : 2024-01-19 Yoko Omi, Juro Yanagida, Yusaku Yoshida, Kiyomi Horiuchi, Takahiro Okamoto
In papillary thyroid carcinoma (PTC) patients with mediastinal lymph nodes (LN) and lung metastases, adding preoperative computed tomography (CT) to ultrasound is useful for planning surgery. We identified risk factors (RFs) for mediastinal lymph node metastasis (MLNM) and lung metastasis in PTC patients. Frequencies of MLNM and lung metastases were compared in 478 patients. Relative risk (RR) was
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Protective effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve of rats with diabetic peripheral neuropathy Endocr. J. (IF 2.0) Pub Date : 2024-01-18 Na Cui, Yonghao Feng, Ming Wang, Xiuyan Lu, Yongmei Huang, Yinghui Chen, Xiaohong Shi
Dyslipidemia has been considered a risk factor for diabetic peripheral neuropathy. Proprotein convertase subtilisin-like/Kexin 9 inhibitor (PCSK9) inhibitors are a new type of lipid-lowering drug currently in clinical use. The role of PCSK9 in diabetic peripheral neuropathy is still unclear. In this study, the effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve in rats with diabetic peripheral
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The impact of serum testosterone level to reflect age-related multi-organ functions Endocr. J. (IF 2.0) Pub Date : 2024-01-06 Tomoya Shirakawa, Julius Fink, Zen-u Hotta, Yosuke Shimada, Yan Lu, Junhua Du, Kazuhito Matsushita, Satoshi Hori, Hisamitsu Ide, Shigeo Horie
The aim of this study is to examine the correlation between aging, serum total testosterone and biomarkers of multiple organ functions in men. The participants consisted of 12,547 outpatients, whose serum testosterone level was measured. A multiple regression analysis was conducted to determine whether biomarkers including hemoglobin (Hb), hematocrit (Hct), luteinizing hormone (LH), follicle stimulating
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Pathology and gene mutations of aldosterone-producing lesions Endocr. J. (IF 2.0) Pub Date : 2023-12-28 Koshiro Nishimoto, Tadashi Ogishima, Yuki Sugiura, Makoto Suematsu, Kuniaki Mukai
The human adrenal cortex secretes aldosterone and cortisol as major corticosteroids. For their production, CYP11B2 and CYP11B1 catalyze the last steps in the syntheses of aldosterone and cortisol, respectively. In our previous study, CYP11B2 was the first successfully purified from rat adrenals and human clinical samples and then was proved to be aldosterone synthase. We demonstrated the immunohistochemistry
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Associations between a polygenic risk score and the risk of gestational diabetes mellitus in a Chinese population: a case-control study Endocr. J. (IF 2.0) Pub Date : 2023-12-28 Ying Li, Mengjiao Yang, Lu Yuan, Ting Li, Xinli Zhong, Yanying Guo
Our objective was to construct a polygenic risk score (PRS) and assess its utility and effectiveness in predicting the risk of gestational diabetes mellitus (GDM) in a Chinese population. We performed a case-control study involving 638 patients with GDM and 1,062 healthy controls. Genotyping was conducted utilizing a genome-wide association study (GWAS), and a PRS was constructed. We identified 12
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Differences in metabolic characteristics between Metabolically Healthy Obesity (MHO) and Metabolically Unhealthy Obesity (MUO) in weight reduction therapy Endocr. J. (IF 2.0) Pub Date : 2023-12-28 Shiori Kawai, Hajime Yamakage, Kazuhiko Kotani, Mitsuhiko Noda, Noriko Satoh-Asahara, Koshi Hashimoto
Metabolically Healthy Obesity (MHO) is generally recognized as the absence of any metabolic disorders and cardiovascular diseases, including type 2 diabetes, dyslipidemia, and hypertension, in obese individuals; however, it is not clearly defined. Therefore, the present study investigated differences in metabolic characteristics between individuals with MHO and Metabolically Unhealthy Obesity (MUO)
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Lung adenocarcinoma metastasis within a pituitary neuroendocrine tumor: a case report with review of literature Endocr. J. (IF 2.0) Pub Date : 2023-12-29 Koji Suzuki, Shigeyuki Tahara, Yujiro Hattori, Shinichiro Teramoto, Eitaro Ishisaka, Chie Inomoto, Robert Yoshiyuki Osamura, Akio Morita, Yasuo Murai
Collision tumors involving the metastasis of malignant neoplasms to pituitary neuroendocrine tumors (PitNETs) are extremely rare. We herein report a case involving a patient with lung adenocarcinoma metastasis within a PitNET who exhibited relatively rapid progression of neurological symptoms. A 75-year-old man who underwent tumor resection 36 and 18 years prior to presentation for bladder and colon
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Relationship between Ca2+ and cAMP as second messengers in ACTH-induced cortisol production in bovine adrenal fasciculata cells Endocr. J. (IF 2.0) Pub Date : 2023-12-28 Masahiko Kutsukake, Naoko Kuwabara, Yoshikazu Miyate, Kenzo Kudo, Shoko Goto, Eiichi Taira, Eiichi Tachikawa
In adrenal fasciculata cells stimulated by ACTH, Ca2+ and cAMP play indispensable roles as second messengers in cortisol production. However, whether their second messengers cooperatively or independently participate in steroid production remains unclear. We focused on the roles of Ca2+ and cAMP in cortisol production in bovine adrenal fasciculata cells stimulated by ACTH for a relatively short period
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Region-specific hippocampal atrophy is correlated with poor glycemic control in type 2 diabetes: a cross-sectional study Endocr. J. (IF 2.0) Pub Date : 2023-12-28 Cuiping Bao, Xuehuan Liu, Yiming Li, Jun Yang, Feng Wei, Yi Gong, Zhihui Ma, Jun Liu
To examine the association between prediabetes/type 2 diabetes mellitus (T2DM) and hippocampal subfields and to investigate the effects of glycemic control (HbA1c and FBG)/diabetes duration on the volume of hippocampal subfields in T2DM patients. This cross-sectional study included 268 participants from Tianjin Union Medical Center between August 2019 and July 2022. The participants were divided into
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The oral disposition index calculated from a meal tolerance test is a crucial indicator for evaluating differential normalization of postprandial glucose and triglyceride excursions in morbidly obese patients after laparoscopic sleeve gastrectomy Endocr. J. (IF 2.0) Pub Date : 2023-12-28 Yukako Yamamoto, Takeshi Togawa, Osamu Sekine, Yuki Ozamoto, Junko Fuse, Choka Azuma, Jun Ito-Kobayashi, Yasumitsu Oe, Akeo Hagiwara, Masaki Kobayashi, Tadahiro Kitamura, Masanori Iwanishi, Akira Shimatsu, Atsunori Kashiwagi
To determine the normalization of postprandial blood glucose (PG) and triglyceride (TG) excursions in 30 morbidly obese patients with or without diabetes mellitus (DM) 1-year after they underwent a laparoscopic sleeve gastrectomy (LSG) vs. their pre-surgery data, we administered the 75-g oral glucose tolerance test (OGTT) and a meal tolerance test (MTT) using a 75-g glucose-equivalent carbohydrate-
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Intraindividual variation in histone acetylation and its impact on autoimmune thyroid diseases Endocr. J. (IF 2.0) Pub Date : 2023-12-28 Emi Haga, Naoya Inoue, Yoshinori Iwatani, Yuya Arakawa, Emi Morita, Hidemi Hashimoto, Yusuke Noguchi, Yoh Hidaka, Mikio Watanabe
Autoimmune thyroid diseases (AITDs), such as Graves’ disease (GD) and Hashimoto’s disease (HD), are organ-specific autoimmune diseases. Histone acetylation, especially that of histone H3, is an epigenetic mechanism that regulates gene expression and is associated with the development of autoimmune diseases. However, physiological variations in histone acetylation are not yet clear, and we believe that
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Assessment of factors associated with improved glycemic control after switching from intermittently scanned to real-time continuous glucose monitoring in Japanese patients with type 1 diabetes Endocr. J. (IF 2.0) Pub Date : 2023-12-28 Eijiro Yamada, Yasuyo Nakajima, Kazuhiko Horiguchi, Shuichi Okada, Masanobu Yamada
The advantages of real-time continuous glucose monitoring (rtCGM) over intermittently scanned CGM (isCGM) reportedly include lower glycated hemoglobin (HbA1c) levels as well as reduced glycemic variability. However, there have been few studies of the effect of switching from isCGM to rtCGM on glycemic control, as well as the specific factors underlying any observed improvements. To that end, all patients
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A retrospective study on tolvaptan prescription in clinical practice in patients with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) using the Japanese claims database Endocr. J. (IF 2.0) Pub Date : 2023-12-28 Daisuke Hagiwara, Miyuki Matsukawa, Junko Tasaki, Yumiko Nakamura, Hiroshi Arima
We aimed to survey the status of tolvaptan administration in routine clinical practice since the approval of a novel indication for treating syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in Japan. Data from a population of 3,152 patients aged ≥18 years and diagnosed with SIADH between July 1, 2020 and June 30, 2021 were extracted from a Japanese database. Tolvaptan was administered
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Definition, criteria, and core concepts of guidelines for the management of obesity disease in Japan Endocr. J. (IF 2.0) Pub Date : 2023-12-20 Wataru Ogawa, Yushi Hirota, Shigeru Miyazaki, Tadashi Nakamura, Yoshihiro Ogawa, Iichiro Shimomura, Toshimasa Yamauchi, Koutaro Yokote, on behalf of the Creation Committee for Guidelines for the Management of Obesity Disease 2022 by Japan Society for the Study of Obesity (JASSO)
To identify those who might benefit from weight reduction within a large population of obese individuals, Japan Society for the Study of Obesity (JASSO) advocated the concept of “obesity disease.” Here we summarize the definition, criteria, and core concepts for the management of obesity disease based on JASSO’s latest guideline. JASSO defines obesity as excessive fat storage in adipose tissue associated
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Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism Endocr. J. (IF 2.0) Pub Date : 2023-12-22 Yoshimichi Takeda, Masashi Demura, Mitsuhiro Kometani, Shigehiro Karashima, Daisuke Aono, Seigo Konishi, Shin-ichi Horike, Makiko Meguro-Horike, Takashi Yoneda, Yoshiyu Takeda
11Beta-hydroxysteroid dehydrogenase 1 (11β-HSD1) is a key enzyme involved in metabolic syndrome. Transcript-specific epigenetic regulation of the gene encoding 11β-HSD1 (HSD11B1) has been reported. We examined the mRNA level and methylation status of the HSD11B1 promoter region in the adipose tissue of patients with primary aldosteronism (PA). We compared 10 tissue specimens from patients with PA caused
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Encapsulated human islets in alginate fiber maintain long-term functionality Endocr. J. (IF 2.0) Pub Date : 2023-12-22 Junko Nishida, Takahiro Tsuno, Shigeharu G. Yabe, Tatsuya Kin, Satsuki Fukuda, Fujie Takeda, Jun Shirakawa, Hitoshi Okochi
Maintenance of islet function after in vitro culture is crucial for both transplantation and research. Here we evaluated the effects of encapsulation in alginate fiber on the function of human islets which were distributed by the Alberta Islet Distribution Program. Encapsulated human islets from 15 deceased donors were cultured under 5.5 or 25 mM glucose conditions in vitro. The amounts of C-peptide
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Preoperative neck ultrasound combined with pathological data can significantly impact the outcome of medullary thyroid carcinoma Endocr. J. (IF 2.0) Pub Date : 2023-11-28 Maurilio Deandrea, Tommaso Piticchio, Alberto Mormile, Francesca Retta, Giovanni Canale, Alessandra Caracciolo, Lorenzo Daniele, Pierpaolo Trimboli
The diagnosis of medullary thyroid carcinoma (MTC) is challenging since the accuracy of ultrasound (US) and fine-needle aspiration cytology are suboptimal. As a result, MTC has a generally poor prognosis. The aim of this study was to analyze whether perioperative data can modify the risk of relapse in these patients. The institutional database of Turin Mauriziano Hospital was searched to extract records
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Different post-pancreatectomy glucagon responses to a meal test between surgical approaches Endocr. J. (IF 2.0) Pub Date : 2023-11-28 Tsuguka Matsuda, Natsumi Himeno, Akira Nakashima, Naoya Nakagawa, Toshihiko Kohashi, Dan Kawamori, Nozomu Kamei
Residual pancreatic endocrine function is important for maintaining metabolic status after pancreatectomy and is closely related to patient nutritional status and prognosis. In contrast to insulin secretion, the significance of glucagon secretion following pancreatectomy remains unclear. In this study, we assessed the changes in pancreatic glucagon secretion during pancreatectomy to determine their
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A case report of anaplastic thyroid carcinoma transformed from small papillary carcinoma successfully detected by ultrasonography in its early stage with review of literature Endocr. J. (IF 2.0) Pub Date : 2023-11-28 Hiroshi Arimitsu, Yui Nishijima, Naoyuki Higaki, Hitoshi Noguchi, Shinya Uchino, Tsukasa Murakami
An 82-year-old woman was referred to our hospital because of a suspicious thyroid nodule. She was diagnosed with papillary microcarcinoma with a maximum diameter of 9 mm based on ultrasonography and fine-needle aspiration (FNA) cytology. She preferred observation without surgery. Her papillary carcinoma grew gradually and reached a maximum diameter of 19 mm after 23 months. At that time, ultrasonography
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TERT promoter mutations in thyroid cancer Endocr. J. (IF 2.0) Pub Date : 2023-11-28 Michiko Matsuse, Norisato Mitsutake
TERT promoter mutations (TERT-p mutations) have been found in many types of cancer and have emerged to play critical roles in tumor progression. The mutations upregulate TERT transcription, and TERT not only elongates telomeres and confers unlimited proliferative capacity on tumor cells, but is also involved in tumor progression and aggressiveness. In differentiated thyroid carcinoma, TERT-p mutations
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The effect of acromegaly on thyroid disease Endocr. J. (IF 2.0) Pub Date : 2023-11-28 Caiyan Mo, Liyong Zhong
Long-term stimulation of thyroid follicular epithelium by high growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in patients with acromegaly can lead to thyroid dysfunction, goiter, thyroid nodules, and even thyroid cancer and thyroid-associated ophthalmopathy (TAO). Excessive GH/IGF-1 promotes goiter and thyroid nodule formation, which can be reversed by normalizing the IGF-1 levels with
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Proposed carbohydrate antigen 19-9 (CA19-9) cut-off values for the detection of pancreatic cancer in patients with poorly controlled diabetes: a real-world study Endocr. J. (IF 2.0) Pub Date : 2023-11-28 Taku Yamada, Taichi Minami, Masayo Yamada, Yasuo Terauchi
CA19-9 is a tumor marker for pancreatic cancer (PC), and the nondiabetic cut-off level is 37 U/mL. CA19-9 levels are said to rise in patients with tumors like PC and intraductal papillary mucinous neoplasm (IPMN). CA19-9 levels have also been shown to be related to HbA1c levels. We hypothesized that the CA19-9 cut-off levels would differ between patients with poorly controlled diabetes. This real-world