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The Role of Probiotics in Managing Glucose Homeostasis in Adults with Prediabetes: A Systematic Review and Meta-Analysis J. Diabetes Res. (IF 4.3) Pub Date : 2024-3-18 Chao Sun, Qingyin Liu, Xiaona Ye, Ronghua Li, Miaomiao Meng, Xingjun Han
Background and Purpose. There is controversy about the effect of probiotics in regulating glucose homeostasis. This systematic review and meta-analysis is aimed at evaluating the evidence for the efficacy of probiotics in managing blood glucose, blood lipid, and inflammatory factors in adults with prediabetes. Methods. The Preferred Reporting Items for Systematic Reviews and Analysis checklist was
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Effects of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors on Intima-Media Thickness: Systematic Review and Meta-Analysis J. Diabetes Res. (IF 4.3) Pub Date : 2024-3-18 Abolfazl Akbari, Shiva Hadizadeh, Leida Heidary
Background. Beyond glycemic control, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2is) have been proposed to reduce the risk of cardiovascular events. The aim of the present systematic review and meta-analysis is to demonstrate the effects of GLP-1 RA and SGLT2is on intima-media thickness (IMT). Methods. PubMed, EMBASE, Web of Science, SCOPUS
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Identification and Validation of the Pyroptosis-Related Hub Gene Signature and the Associated Regulation Axis in Diabetic Keratopathy J. Diabetes Res. (IF 4.3) Pub Date : 2024-3-18 Yi Cui, Li Wang, Wentao Liang, Li Huang, Shuting Zhuang, Hong Shi, Nuo Xu, Jianzhang Hu
Background. Diabetic keratopathy (DK) poses a significant challenge in diabetes mellitus, yet its molecular pathways and effective treatments remain elusive. The aim of our research was to explore the pyroptosis-related genes in the corneal epithelium of the streptozocin-induced diabetic rats. Methods. After sixteen weeks of streptozocin intraperitoneal injection, corneal epithelium from three diabetic
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Jian-Pi-Gu-Shen-Hua-Yu Decoction Alleviated Diabetic Nephropathy in Mice through Reducing Ferroptosis J. Diabetes Res. (IF 4.3) Pub Date : 2024-3-16 Shuquan Lv, Lirong Fan, Xiaoting Chen, Xiuhai Su, Li Dong, Qinghai Wang, Yuansong Wang, Hui Zhang, Huantian Cui, Shufang Zhang, Lixin Wang
Background. Diabetic nephropathy (DN), one of the most frequent complications of diabetes mellitus, is a leading cause of end-stage renal disease. However, the current treatment methods still cannot effectively halt the progression of DN. Jian-Pi-Gu-Shen-Hua-Yu (JPGS) decoction can be used for the treatment of chronic kidney diseases such as DN, but the specific mechanism of action has not been fully
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Does Treatment with Sodium-Glucose Cotransporter-2 Inhibitors Affect Adherence to International Society Criteria for Diabetic Ketoacidosis in Adult Patients with Type 2 Diabetes? A Retrospective Cohort Analysis J. Diabetes Res. (IF 4.3) Pub Date : 2024-3-14 Aongus O’Brolchain, Joshua Maletsky, Ibrahim Mian, Serena Edwards
Objective(s). Diabetic ketoacidosis (DKA) is a rare but well-known complication of sodium-glucose transporter inhibitor (SGLT2i) treatment in patients with type 2 diabetes. The physiological effects of SGLT2i are such that hyperglycaemia and ketonuria are no longer reliable diagnostic tools in patients treated with this class of medication. Diagnostic criteria for DKA varies between major society guidelines
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Beneficial Effects of Ursodeoxycholic Acid on Metabolic Parameters and Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind, Placebo-Controlled Clinical Study J. Diabetes Res. (IF 4.3) Pub Date : 2024-2-29 Biljana Lakić, Ranko Škrbić, Snežana Uletilović, Nebojša Mandić-Kovačević, Milkica Grabež, Mirna Popović Šarić, Miloš P. Stojiljković, Ivan Soldatović, Zorica Janjetović, Anastasija Stokanović, Nataša Stojaković, Momir Mikov
Background. Oxidative stress and inflammation are closely related pathophysiological processes, both occurring in type 2 diabetes mellitus (T2DM). In addition to the standard treatment of T2DM, a potential strategy has been focused on the use of bile acids (BAs) as an additional treatment. Ursodeoxycholic acid (UDCA), as the first BA used in humans, improves glucose and lipid metabolism and attenuates
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Exosomes as Emerging Regulators of Immune Responses in Type 2 Diabetes Mellitus J. Diabetes Res. (IF 4.3) Pub Date : 2024-2-29 Wei Zheng, Xin Ji, Qiao qiao Yin, Chensi Wu, Chengan Xu, Hongying Pan, Chun Wu
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by high blood glucose levels resulting from insulin resistance and impaired insulin secretion. Immune dysregulation-mediated chronic low-grade inflammation is a critical factor that poses a significant risk to the metabolic disorders of T2DM and its related complications. Exosomes, as small extracellular vesicles secreted
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The Effects of Resistance Exercise Training on Skeletal Muscle Metabolism and Insulin Resistance Development in Female Rodents with Type 1 Diabetes J. Diabetes Res. (IF 4.3) Pub Date : 2024-2-22 Mitchell J. Sammut, David P. McBey, Amit P. Sayal, C. W. James Melling
The etiology of insulin resistance (IR) development in type 1 diabetes mellitus (T1DM) remains unclear; however, impaired skeletal muscle metabolism may play a role. While IR development has been established in male T1DM rodents, female rodents have yet to be examined in this context. Resistance exercise training (RT) has been shown to improve IR and is associated with a lower risk of hypoglycemia
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Advances in Research Related to MicroRNA for Diabetic Retinopathy J. Diabetes Res. (IF 4.3) Pub Date : 2024-2-12 Yahan Luo, Chunxia Li
Diabetic retinopathy (DR) is a severe microvascular complication of diabetes and is one of the primary causes of blindness in the working-age population in Europe and the United States. At present, no cure is available for DR, but early detection and timely intervention can prevent the rapid progression of the disease. Several treatments for DR are known, primarily ophthalmic treatment based on glycemia
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Translation of a Diabetes Remission Service into Australian Primary Care: Findings from the Evaluation of DiRECT-Australia J. Diabetes Res. (IF 4.3) Pub Date : 2024-2-8 Ritesh Chimoriya, Kimberly Mitlehner, Chee L. Khoo, Uchechukwu Levi Osuagwu, Russell Thomson, Lei Si, Michael Lean, David Simmons, Milan K. Piya
Background. The Diabetes Remission Clinical Trial (DiRECT) study demonstrated that an intensive and structured weight management program in UK primary care resulted in high rates of diabetes remission in adults with recent onset type 2 diabetes mellitus (T2DM). This study was aimed at evaluating the translation of the DiRECT intervention into an Australian primary care setting. Methods. All patients
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Does Pre-existing Diabetes Correlate with Long COVID-19 in Europe? Evidence from the Analysis of the Survey of Health, Ageing and Retirement in Europe’s Corona Surveys J. Diabetes Res. (IF 4.3) Pub Date : 2024-2-2 Sarah Cuschieri, Piotr Wilk
Background. A substantial proportion of those infected with COVID-19 are presenting with persistent symptoms, referred to as long COVID-19. Emerging evidence suggests that the presence of pre-existing chronic conditions, such as diabetes, may increase the risk of long COVID-19. Objectives. To investigate whether having pre-existing diabetes increases the risk of developing long COVID-19 in the population
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Identification of Senescence-Associated Biomarkers in Diabetic Glomerulopathy Using Integrated Bioinformatics Analysis J. Diabetes Res. (IF 4.3) Pub Date : 2024-1-23 Li Zhang, Zhaoxiang Wang, Fengyan Tang, Menghuan Wu, Ying Pan, Song Bai, Bing Lu, Shao Zhong, Ying Xie
Background. Cellular senescence is thought to play a significant role in the onset and development of diabetic nephropathy. The goal of this study was to explore potential biomarkers associated with diabetic glomerulopathy from the perspective of senescence. Methods. Datasets about human glomerular biopsy samples related to diabetic nephropathy were systematically obtained from the Gene Expression
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Tailoring Type II Diabetes Treatment: Investigating the Effect of 5-HTT Polymorphisms on HbA1c Levels after Metformin Initiation J. Diabetes Res. (IF 4.3) Pub Date : 2024-1-22 Taichi Ochi, Stijn de Vos, Daan Touw, Petra Denig, Talitha Feenstra, Eelko Hak
Aims. To investigate the effect of serotonin transporter (5-HTT) polymorphisms on change in HbA1c levels six months after metformin initiation in type 2 diabetes patients. Materials and Methods. Participants of PROVALID (PROspective cohort study in patients with type 2 diabetes mellitus for VALidation of biomarkers) within the GIANTT (Groningen Initiative to ANalyse Type 2 Diabetes Treatment) cohort
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Unveiling the Hidden Burden: Estimating All-Cause Mortality Risk in Older Individuals with Type 2 Diabetes J. Diabetes Res. (IF 4.3) Pub Date : 2024-1-20 Dikang Pan, Hui Wang, Sensen Wu, Jingyu Wang, Yachan Ning, Jianming Guo, Cong Wang, Yongquan Gu
Background. The mortality rate among older persons with diabetes has been steadily increasing, resulting in significant health and economic burdens on both society and individuals. The objective of this study is to develop and validate a predictive nomogram for estimating the 5-year all-cause mortality risk in older persons with T2D (T2D). Methods. We obtained data from the National Health and Nutrition
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Explainable Machine Learning-Based Prediction Model for Diabetic Nephropathy J. Diabetes Res. (IF 4.3) Pub Date : 2024-1-20 Jing-Mei Yin, Yang Li, Jun-Tang Xue, Guo-Wei Zong, Zhong-Ze Fang, Lang Zou
The aim of this study is to analyze the effect of serum metabolites on diabetic nephropathy (DN) and predict the prevalence of DN through a machine learning approach. The dataset consists of 548 patients from April 2018 to April 2019 in the Second Affiliated Hospital of Dalian Medical University (SAHDMU). We select the optimal 38 features through a least absolute shrinkage and selection operator (LASSO)
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Huaju Xiaoji Formula Regulates ERS-lncMGC/miRNA to Enhance the Renal Function of Hypertensive Diabetic Mice with Nephropathy J. Diabetes Res. (IF 4.3) Pub Date : 2024-1-20 Zeng Zhang, Xiaodong Fu, Fengzhu Zhou, Duanchun Zhang, Yanqiu Xu, Zhaohua Fan, Shimei Wen, Yanting Shao, Zheng Yao, Yanming He
Background. Better therapeutic drugs are required for treating hypertensive diabetic nephropathy. In our previous study, the Huaju Xiaoji (HJXJ) formula promoted the renal function of patients with diabetes and hypertensive nephropathy. In this study, we investigated the therapeutic effect and regulation mechanism of HJXJ in hypertensive diabetic mice with nephropathy. Methods. We constructed a mouse
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Glucose Fluctuation Inhibits Nrf2 Signaling Pathway in Hippocampal Tissues and Exacerbates Cognitive Impairment in Streptozotocin-Induced Diabetic Rats J. Diabetes Res. (IF 4.3) Pub Date : 2024-1-19 Haiyan Chi, Yujing Sun, Peng Lin, Junyu Zhou, Jinbiao Zhang, Yachao Yang, Yun Qiao, Deshan Liu
Background. This research investigated whether glucose fluctuation (GF) can exacerbate cognitive impairment in streptozotocin-induced diabetic rats and explored the related mechanism. Methods. After 4 weeks of feeding with diets containing high fats plus sugar, the rat model of diabetes mellitus (DM) was established by intraperitoneal injection of streptozotocin (STZ). Then, GF was triggered by means
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Is eGFR Slope a Novel Predictor of Chronic Complications of Type 2 Diabetes Mellitus? A Systematic Review and Meta-Analysis J. Diabetes Res. (IF 4.3) Pub Date : 2024-1-17 Giovanni Sartore, Eugenio Ragazzi, Elena Deppieri, Annunziata Lapolla
Background. Diabetic kidney disease affects approximately 40% of patients with type 2 diabetes mellitus (T2DM) and is associated with an increased risk of end-stage kidney disease (ESKD) and cardiovascular (CV) events, as well as increased mortality. Among the indicators of decline in renal function, the eGFR slope is acquiring an increasing clinical interest. The aim of this study was to evaluate
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Association of Monocyte-to-HDL Cholesterol Ratio with Endothelial Dysfunction in Patients with Type 2 Diabetes J. Diabetes Res. (IF 4.3) Pub Date : 2024-1-11 Huihui Zhang, Jun Lu, Jie Gao, Wenjun Sha, Xinhua Cai, Mai Re Yan Mu Rouzi, Yuanying Xu, Wenjun Tang, Tao Lei
Aims. To explore the relationship between monocyte-to-HDL cholesterol ratio (MHR) and endothelial function in patients with type 2 diabetes (T2DM). Methods. 243 patients diagnosed with T2DM were enrolled in this cross-sectional study. Patients were divided into two groups by flow-mediated dilation (FMD) quintile as nonendothelial dysfunction () and endothelial dysfunction (). The relationship between
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Pathology of Ketoacidosis in Emergency of Diabetic Ketoacidosis and Alcoholic Ketoacidosis: A Retrospective Study J. Diabetes Res. (IF 4.3) Pub Date : 2024-1-8 Katsumasa Koyama, Takatoshi Anno, Yukiko Kimura, Fumiko Kawasaki, Kohei Kaku, Koichi Tomoda, Hideaki Kaneto
This study is aimed at examining which factors are useful for the diagnosis and distinction of ketoacidosis. We recruited 21 diabetic ketoacidosis (DKA) and alcoholic ketoacidosis (AKA) patients hospitalized in Kawasaki Medical School General Medical Center from April 2015 to March 2021. Almost all patients in this study were brought to the emergency room in a coma and hospitalized. All patients underwent
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A Multicenter, Randomized, Open-Label Study to Compare the Effects of Gemigliptin Add-on or Escalation of Metformin Dose on Glycemic Control and Safety in Patients with Inadequately Controlled Type 2 Diabetes Mellitus Treated with Metformin and SGLT-2 Inhibitors (SO GOOD Study) J. Diabetes Res. (IF 4.3) Pub Date : 2024-1-5 Hae Jin Kim, Jung Hyun Noh, Min Kyong Moon, Sung Hee Choi, Seung-Hyun Ko, Eun-Jung Rhee, Kyu Yeon Hur, In-Kyung Jeong
Background. We aimed to compare efficacy and safety between gemigliptin add-on and escalation of the metformin dose in patients with inadequately controlled type 2 diabetes mellitus (T2DM) despite treatment with metformin and SGLT2 inhibitors. Methods. This study was a multicenter, randomized, open-label, active-controlled, parallel-group comparative study. Patients with T2DM uncontrolled on metformin
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Usefulness of Once-Weekly GLP-1 Receptor Agonist Semaglutide on Glycemic Control in Subjects with Type 2 Diabetes Mellitus: Switching from the Same Class Dulaglutide in a Retrospective Observation Study J. Diabetes Res. (IF 4.3) Pub Date : 2024-1-4 Tomohiko Kimura, Masato Kubo, Kaio Takahashi, Ryo Wamata, Yuichiro Iwamoto, Hideyuki Iwamoto, Yukino Katakura, Junpei Sanada, Yoshiro Fushimi, Masashi Shimoda, Fuminori Tatsumi, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
Recently, the development of once-weekly incretin-based injections dulaglutide and semaglutide has drawn a great deal of attention. This study is aimed at comparing the efficacy of once-weekly GLP-1 receptor activator (GLP-1RA) dulaglutide and semaglutide on glycemic control and several metabolic parameters in patients with type 2 diabetes mellitus. We compared various clinical parameters between before
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Lactiplantibacillus plantarum NKK20 Increases Intestinal Butyrate Production and Inhibits Type 2 Diabetic Kidney Injury through PI3K/Akt Pathway J. Diabetes Res. (IF 4.3) Pub Date : 2023-12-23 Xiaohong Sun, Yue Xi, Man Yan, Chang Sun, Jianjun Tang, Xueyun Dong, Zhengnan Yang, Liang Wu
Nephropathy injury is a prevalent complication observed in individuals with diabetes, serving as a prominent contributor to end-stage renal disease, and the advanced glycation products (AGEs) are important factors that induce kidney injury in patients with diabetes. Addressing this condition remains a challenging aspect in clinical practice. The aim of this study was to explore the effects of Lactiplantibacillus
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Renewable Human Cell Model for Type 1 Diabetes Research: EndoC-βH5/HUVEC Coculture Spheroids J. Diabetes Res. (IF 4.3) Pub Date : 2023-12-23 James M. Porter, Michael Yitayew, Maryam Tabrizian
In vitro drug screening for type 1 diabetes therapies has largely been conducted on human organ donor islets for proof of efficacy. While native islets are the ultimate target of these drugs (either in situ or for transplantation), significant benefit can be difficult to ascertain due to the highly heterogeneous nature of individual donors and the overall scarcity of human islets for research. We present
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A Novel Risk Score Model for the Differential Diagnosis of Type 2 Diabetic Nephropathy: A Multicenter Study J. Diabetes Res. (IF 4.3) Pub Date : 2023-12-21 Yuetong Zhao, Lin Liu, Li Zuo, Xianghai Zhou, Song Wang, Hongwei Gao, Feng Yu, Xiaomei Zhang, Mi Wang, Ling Chen, Rui Zhang, Fang Zhang, Shuhong Bi, Qiong Bai, Jiaxiang Ding, Qinghua Yang, Sixu Xin, Sanbao Chai, Min Chen, Junqing Zhang
Introduction. DN is a common complication of diabetes. However, diabetes combined with renal injury may involve DN or NDKD, with different treatment schemes. The purpose of our study was to determine the independent risk factors of DN and establish a risk score model to help differentiate DN and NDKD, providing a reference for clinical treatment. Methods. A total of 678 T2D patients who had undergone
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The Relationship between Muscle Ultrasound Parameters and Diabetic Peripheral Neuropathy among Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study J. Diabetes Res. (IF 4.3) Pub Date : 2023-12-19 Yanling Zhong, Xiaojia Liu, Teng Lin
Background. Muscle dysfunction is an early complication of diabetic peripheral neuropathy (DPN). As a convenient and low-cost tool, muscle ultrasound has been used to assess muscle quality and muscle mass. However, the relationship between different muscle ultrasound parameters and DPN is unclear. Objectives. This study was designed to investigate the relationship between ultrasound parameters of different
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Cost-Effectiveness of Bariatric Surgery in Patients Living with Obesity and Type 2 Diabetes J. Diabetes Res. (IF 4.3) Pub Date : 2023-12-16 Gábor Kovács, Elemér Mohos, János Tibor Kis, Ádám Tabák, Péter Gerendy, Judit Pettkó, Dávid Nagy, Dávid Győrbíró, Zoltán Kaló
Aims. The favourable effects of bariatric surgeries on body weight reduction and glucose control have been demonstrated in several studies. Additionally, the cost-effectiveness of bariatric surgeries has been confirmed in several analyses. The aim of the current analysis was to demonstrate the cost-effectiveness of bariatric surgeries in obese patients with type 2 diabetes in Hungary compared to conventional
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The Effect of Telenursing on Disease Outcomes in People with Type 2 Diabetes Mellitus: A Narrative Review J. Diabetes Res. (IF 4.3) Pub Date : 2023-12-7 Mina AkbariRad, Mohsen Dehghani, Masoumeh Sadeghi, Ashkan Torshizian, Nikoo Saeedi, Mehrdad Sarabi, Mahdieh Sahebi, Mohammad Taghi Shakeri
Background and Aim. Diabetes is the most common chronic metabolic disease worldwide, requiring life-term follow-up. Telenursing is a suitable method to provide care to people with type 2 diabetes mellitus (T2DM). The present review assessed the effect of telenursing compared to routine care on the outcomes of people with T2DM. Method. A comprehensive search of online databases, including PubMed, Scopus
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Coagulation Function and Type 2 Diabetic Kidney Disease: A Real-World Observational Study J. Diabetes Res. (IF 4.3) Pub Date : 2023-12-6 Meng-chao Liu, Wen-quan Niu, Yue-fen Wang, Yuan Meng, Gui-min Zheng, Zhen Cai, Cun Shen, Xiang-gang Zhu, Meng-di Wang, Jia-lin Li, Wen-jing Zhao, Yao-xian Wang
Objectives. Type 2 diabetic kidney disease (DKD), a chronic microvascular complication of diabetes, may exhibit a complex interrelation with coagulation function. This study is aimed at elucidating the association between coagulation function and DKD. Methods. This was a real-world observational study conducted in Beijing, involving 2,703 participants. All patients with diabetes were classified into
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Role of Gut Microbiota, Immune Imbalance, and Allostatic Load in the Occurrence and Development of Diabetic Kidney Disease J. Diabetes Res. (IF 4.3) Pub Date : 2023-12-6 Yi Zhen Han, Hui Juan Zheng, Bo Xuan Du, Yi Zhang, Xing Yu Zhu, Jing Li, Yao Xian Wang, Wei Jing Liu
Diabetic kidney disease (DKD) is a prevailing complication arising from diabetes mellitus. Unfortunately, there are no trustworthy and efficacious treatment modalities currently available. In recent times, compelling evidence has emerged regarding the intricate correlation between the kidney and the gut microbiota, which is considered the largest immune organ within the human physique. Various investigations
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The Effect of a Patient Activation Tailored Intervention on Type 2 Diabetes Self-Management and Clinical Outcomes: A Study from Saudi Arabian Primary Care Settings J. Diabetes Res. (IF 4.3) Pub Date : 2023-11-27 Nasser Almutairi, Vinod Gopaldasani, Hassan Hosseinzadeh
Background. Type 2 diabetes mellitus (T2DM) is a global public health challenge. T2DM self-management, including diet, physical activity, blood glucose self-monitoring, foot care, and adherence to medication, is considered a primary tool for managing diabetes. Patient activation, an individual’s knowledge, skill, and confidence in managing their health and healthcare, was recognized to be associated
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Determinants and Characteristics of Insulin Dose Requirements in Children and Adolescents with New-Onset Type 1 Diabetes: Insights from the INSENODIAB Study J. Diabetes Res. (IF 4.3) Pub Date : 2023-11-26 Maude Beckers, Olivier Polle, Paola Gallo, Noémie Bernard, Céline Bugli, Philippe A. Lysy
Aims. New-onset type 1 diabetes mellitus (T1D) in pediatric patients represents a clinical challenge for initial total daily insulin dosing (TIDD) due to substantial heterogeneity in practice and lack of consensus on the optimal starting dose. Our INSENODIAB (INsulin SEnsitivity in New Onset type 1 DIABetes) study is aimed at (1) exploring the influence of patient-specific characteristics on insulin
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Therapeutic Benefit of Vernonia amygdalina in the Treatment of Diabetes and Its Associated Complications in Preclinical Studies J. Diabetes Res. (IF 4.3) Pub Date : 2023-11-22 Du-Bois Asante, Gideon Akuamoah Wiafe
Diabetes mellitus (DM), a complex heterogeneous metabolic disorder characterized by a defect in the function of insulin, is on the rapid rise globally. Sustained hyperglycemia which is a major sign of DM is linked to the generation of reactive oxygen species which promotes adverse complications of the disorder. Traditional herbal treatment of DM is a common practice in Africa and other tropical parts
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High-Glucose-Induced Injury to Proximal Tubules of the Renal System Is Alleviated by Netrin-1 Suppression of Akt/mTOR J. Diabetes Res. (IF 4.3) Pub Date : 2023-11-21 Chenxiao Liu, Xingna Hu, Yun Zhao, Aijie Huang, Jiaqi Chen, Ting Lu, Mian Wu, Honghong Lu
The kidneys have a high level of Netrin-1 expression, which protects against some acute and chronic kidney disorders. However, it is yet unknown how Netrin-1 affects renal proximal tubule cells in diabetic nephropathy (DN) under pathological circumstances. Research has shown that autophagy protects the kidneys in animal models of renal disease. In this study, we looked at the probable autophagy regulation
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Malnutrition Is Associated with Diabetic Retinopathy in Patients with Type 2 Diabetes J. Diabetes Res. (IF 4.3) Pub Date : 2023-11-17 Wen Wei, Ruiyu Lin, Shihai Li, Zheyuan Chen, Qianqian Kang, Fenyan Lv, Wenying Zhong, Hangju Chen, Mei Tu
Background. The relationship between malnutrition and diabetic retinopathy (DR) is still unclear. The purpose of this study is to investigate the relationship between malnutrition and DR in type 2 diabetic patients. Methods. A cross-sectional study was conducted on 612 patients with type 2 diabetes mellitus. Four malnutrition assessment tools: Global Leadership Initiative on Malnutrition (GLIM) criteria
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Increased Insulin Secretion and Glucose Effectiveness in Obese Patients with Type 2 Diabetes following Bariatric Surgery J. Diabetes Res. (IF 4.3) Pub Date : 2023-11-14 Roberto Visentin, Katrine Brodersen, Bjørn Richelsen, Niels Møller, Chiara Dalla Man, Andreas Kristian Pedersen, Jan Abrahamsen, Jens Juul Holst, Michael Festersen Nielsen
Background. β-cell dysfunction and insulin resistance are the main mechanisms causing glucose intolerance in type 2 diabetes (T2D). Bariatric surgeries, i.e., sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB), are procedures both known to induce weight loss, increase insulin action, and enhance β-cell function, but hepatic insulin extraction and glucose effectiveness may also play a role
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The Effects of Antioxidants and Pulsed Magnetic Fields on Slow and Fast Skeletal Muscle Atrophy Induced by Streptozotocin: A Preclinical Study J. Diabetes Res. (IF 4.3) Pub Date : 2023-11-13 Bora Tastekin, Aykut Pelit, Tugce Sapmaz, Alper Celenk, Muhammed Majeed, Lakshmi Mundkur, Kalyanam Nagabhushanam
Background and Objectives. Skeletal muscle atrophy, a condition characterized by decreased muscle mass and contractility, is commonly observed in various pathological states, including prolonged inactivity, malnutrition, sarcopenia, and type 1 diabetes mellitus (T1DM). We aimed to investigate the potential therapeutic effects of pterostilbene (PTS), resveratrol (RSV), pulsed magnetic field (PMF), and
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Diabetes Mellitus and Gastric Cancer: Correlation and Potential Mechanisms J. Diabetes Res. (IF 4.3) Pub Date : 2023-11-9 Li Wang, Zhe Zhang
This review summarizes the correlation between diabetes mellitus (DM) and gastric cancer (GC) from the perspectives of epidemiology, drug use, and potential mechanisms. The association between DM and GC is inconclusive, and the positive direction of the association reported in most published meta-analyses suggests that DM may be an independent risk factor for GC. Many clinical investigations have shown
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Risk of Neurodegenerative Diseases in Elderly Koreans with an Initial Diagnosis of Type 2 Diabetes: A Nationwide Retrospective Cohort Study J. Diabetes Res. (IF 4.3) Pub Date : 2023-11-8 Hee-Cheol Kim, Ho-Jun Lee, Yang-Tae Kim, Byeong-Churl Jang
Type 2 diabetes (T2D) and neurodegenerative diseases (NDs) are common among elderly individuals. Growing evidence has indicated a strong link between T2D and NDs, such as Alzheimer’s disease. However, previous studies have limitations in exploring the epidemiological relationship among these diseases as a group of NDs rather than as a specific type of ND. We aimed to investigate the risk of NDs in
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Delivering the National Diabetes Prevention Program: Assessment of Outcomes in In-Person and Virtual Organizations J. Diabetes Res. (IF 4.3) Pub Date : 2023-10-26 Elizabeth K. Ely, Boon Peng Ng, Michael J. Cannon
The Centers for Disease Control and Prevention’s Diabetes Prevention Recognition Program (DPRP) has helped organizations deliver the National Diabetes Prevention Program (National DPP) lifestyle change program for over 10 years. Four delivery modes are now approved: in person, online (self-paced, asynchronous delivery), distance learning (remote, synchronous delivery), and combination (hybrid delivery
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A Prediction Model for Sight-Threatening Diabetic Retinopathy Based on Plasma Adipokines among Patients with Mild Diabetic Retinopathy J. Diabetes Res. (IF 4.3) Pub Date : 2023-10-25 Yaxin An, Bin Cao, Kun Li, Yongsong Xu, Wenying Zhao, Dong Zhao, Jing Ke
Background. Accumulating evidence has suggested a link between adipokines and diabetic retinopathy (DR). This study is aimed at investigating the risk factors for sight-threatening DR (STDR) and establishing a prognostic model for predicting STDR among a high-risk population of patients with type 2 diabetes mellitus (T2DM). Methods. Plasma concentrations of adipokines were determined by enzyme-linked
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Fibroblast Growth Factor 21 in Gestational Diabetes Mellitus and Type 2 Diabetes Mellitus J. Diabetes Res. (IF 4.3) Pub Date : 2023-10-14 Katarzyna Gawlik, Tomasz Milewicz, Dorota Pawlica-Gosiewska, Iwona Trznadel-Morawska, Bogdan Solnica
Objective. Women who develop GDM present a metabolic condition similar to that found in type 2 diabetes, characterized by impaired insulin response. Due to similar pathophysiologic mechanisms found between type 2DM and GDM, there is a great interest in finding markers that will lead to the understanding of a possible common origin to both diseases. The aim of this study was to determine serum FGF21
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Rosa laevigata Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway-Mediated Apoptosis and Modulating Tryptophan Metabolism J. Diabetes Res. (IF 4.3) Pub Date : 2023-10-5 Tianyu Zhang, Wenjuan Sun, Lixin Wang, Hui Zhang, Yuansong Wang, Baochao Pan, Hanzhou Li, Ziang Ma, Kai Xu, Huantian Cui, Shuquan Lv
Diabetic nephropathy (DN) is a metabolic disease wherein chronic hyperglycemia triggers various renal cell dysfunctions, eventually leading to progressive kidney failure. Rosa laevigata Michx. is a traditional Chinese herbal medicine. Many studies have confirmed its antioxidative, anti-inflammatory, and renoprotective effects. However, the effects and mechanisms of Rosa laevigata Michx. polysaccharide
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Type 1 and Type 2 Diabetes Measurement Using Human Face Skin Region J. Diabetes Res. (IF 4.3) Pub Date : 2023-9-26 L. Aneesh Euprazia, A. Rajeswari, K. K. Thyagharajan, N. R. Shanker
Aim. Analyse the diabetes mellitus (DM) of a person through the facial skin region using vision diabetology. Diabetes mellitus is caused by persistent high blood glucose levels and related complications, which show variation in facial skin regions due to reduced blood flow in the facial arteries. Materials and Method. In this study, 200 facial images of diabetes patients with skin conditions such as
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β-Aminoisobutyric Acid Relates to Favorable Glucose Metabolism through Adiponectin in Adults with Obesity Independent of Prediabetes J. Diabetes Res. (IF 4.3) Pub Date : 2023-9-21 Habiba Faiz, Emily M. Heiston, Steven K. Malin
β-Aminoisobutyric acid (BAIBA) is secreted by skeletal muscle and promotes insulin sensitivity, fat oxidation, and anti-inflammation. While BAIBA is purportedly lower in individuals with obesity, no work has examined if prediabetes (PD) differentially impacts BAIBA concentrations in people with obesity. Methods. Adults were classified as normal glucose tolerant (NGT; (20F); yrs; kg/m2) or PD ( (18F);
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Epidemiology of Diabetic Ketoacidosis in the Waikato Region of New Zealand: 2000-2019 J. Diabetes Res. (IF 4.3) Pub Date : 2023-9-9 Lynne Chepulis, Valentina Papa, Chunhuan Lao, Justina Wu, Cinthia Minatel Riguetto, Joanna M. McClintock, Ryan G. Paul
Aims. Diabetic ketoacidosis (DKA) is not well characterised in New Zealand. This study is aimed at characterising the change in epidemiology and severity of DKA from 2000 to 2019 at a tertiary hospital in the Waikato region of New Zealand. Methods. A retrospective clinical data review of all patients admitted to Waikato District Health Board hospitals with DKA was undertaken. Characteristics and severity
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Comprehensive Search for GPCR Compounds which Can Enhance MafA and/or PDX-1 Expression Levels Using a Small Molecule Compound Library J. Diabetes Res. (IF 4.3) Pub Date : 2023-9-8 Hideaki Kaneto, Atsushi Obata, Masashi Shimoda, Tomohiko Kimura, Yoshiyuki Obata, Tomoko Ikeda, Saeko Moriuchi, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku
It has been shown that chronic hyperglycemia gradually decreases insulin biosynthesis and secretion which is accompanied by reduced expression of very important insulin gene transcription factors MafA and PDX-1. Such phenomena are well known as β-cell glucose toxicity. It has been shown that the downregulation of MafA and/or PDX-1 expression considerably explains the molecular mechanism for glucose
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The Relationship between Trait Impulsivity and Everyday Executive Functions among Patients with Type 2 Diabetes Mellitus: The Mediating Effect of Negative Emotions J. Diabetes Res. (IF 4.3) Pub Date : 2023-8-22 Na Liu, Chun-Ni Heng, Yi Cui, Ling Li, Yan-Xue Guo, Qin Liu, Bao-Hua Cao, Di Wu, Yin-Ling Zhang
Background. In recent years, the incidence of type 2 diabetes mellitus (T2DM) has dramatically increased, imposing a heavy financial burden on society and individuals. The most cost-effective way to control diabetes is diabetes self-management, which depends on patients’ executive functions (EFs). However, the level of EFs among patients with T2DM varies greatly. In addition to diabetes-related factors
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Colquhounia Root Tablet Promotes Autophagy and Inhibits Apoptosis in Diabetic Nephropathy by Suppressing CD36 Expression In Vivo and In Vitro J. Diabetes Res. (IF 4.3) Pub Date : 2023-8-16 Han Li, Baiju Wang, Changbao Wu, Dandan Xie, Jizhen Li, Na Wang, Hanwen Chen, Lei Liu
Background/Aims. Accumulating clinical evidence suggests that Colquhounia root tablet (CRT) has the potential to alleviate diabetic nephropathy (DN); however, the exact mechanism of action remains unclear. Here, we report the effects of CRT administration on apoptosis and autophagy and attempt to elucidate the underlying mechanisms in vivo and in vitro. Methods. Rat models of DN were established using
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Plasma AGE and Oxidation Products, Renal Function, and Preeclampsia in Pregnant Women with Type 1 Diabetes: A Prospective Observational Study J. Diabetes Res. (IF 4.3) Pub Date : 2023-8-10 Clare B. Kelly, Harsha Karanchi, Jeremy Y. Yu, Misti J. Leyva, Alicia J. Jenkins, Alison J. Nankervis, Kristian F. Hanssen, Satish K. Garg, James A. Scardo, Samar M. Hammad, Christopher E. Aston, Paul J. Beisswenger, Timothy J. Lyons
Aims. We aimed to determine whether plasma advanced glycation end products or oxidation products (AGE/oxidation-P) predict altered renal function and/or preeclampsia (PE) in pregnant women with type 1 diabetes. Methods. Prospectively, using a nested case-control design, we studied 47 pregnant women with type 1 diabetes, of whom 23 developed PE and 24 did not. Nineteen nondiabetic, normotensive pregnant
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The Composite Autonomic Symptom Score 31 Questionnaire: A Sensitive Test to Detect Risk for Autonomic Neuropathy J. Diabetes Res. (IF 4.3) Pub Date : 2023-8-9 Sondre Meling, Erling Tjora, Heike Eichele, Niels Ejskjaer, Siri Carlsen, Pål Rasmus Njølstad, Christina Brock, Eirik Søfteland
Background and Aims. Autonomic neuropathy is a common but often neglected complication of diabetes, prediabetes, and even in individuals with an elevated risk of diabetes. The Composite Autonomic Symptom Score (COMPASS) 31 is a validated and easy-to-use questionnaire regarding autonomic symptoms. We aimed to use a digitally, Norwegian version of the COMPASS 31 in people with different durations of
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Predictors of Responsiveness to GLP-1 Receptor Agonists in Insulin-Treated Patients with Type 2 Diabetes J. Diabetes Res. (IF 4.3) Pub Date : 2023-8-8 Colleen Gavigan, Thomas Donner
Background. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are potent antihyperglycemic agents with beneficial effects on weight, cardiovascular, and renal outcomes. Physicians lack guidance as to which patients with insulin-requiring type 2 diabetes will respond best to GLP-1 RAs with respect to glycemic control, insulin dose reduction, and weight loss. This study evaluated the efficacy of
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Impact of a Novel Hydrogel with Injectable Platelet-Rich Fibrin in Diabetic Wound Healing J. Diabetes Res. (IF 4.3) Pub Date : 2023-7-28 Limin Bai, Xiaowei Zhang, Xiaomei Li, Susu Wang, Yeshun Zhang, Gang Xu
Diabetic wounds are serious complications caused by diabetes mellitus (DM), which are further exacerbated by angiogenesis disorders and prolonged inflammation. Injectable platelet-rich fibrin (i-PRF) is rich in growth factors (GFs) and has been used for the repair and regeneration of diabetic wounds; however, direct application of i-PRF has certain disadvantages, including the instability of the bioactive
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New Insights into the Role of Oxidative Stress in the Development of Diabetes Mellitus and Its Complications. J. Diabetes Res. (IF 4.3) Pub Date : 2023-07-26 Julia Matzenbacher Dos Santos,Qing Zhong,Sandra A Benite-Ribeiro,Thiago Gomes Heck
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Factors Affecting Intensive Aflibercept Treatment Response in Diabetic Macular Edema: A Real-World Study J. Diabetes Res. (IF 4.3) Pub Date : 2023-7-18 Ye Eun Han, Jaehyuck Jo, Yoon Jeon Kim, Junyeop Lee
Objective. To investigate the systemic and ocular factors that affect the response to intensive aflibercept treatment in diabetic macular edema (DME) in a real-world setting. Methods. This retrospective cohort study evaluated 30 eyes of 23 patients with DME who underwent intensive intravitreal aflibercept injections (five monthly loading doses). Treatment response was assessed by central retinal thickness
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Diabetes Detection Models in Mexican Patients by Combining Machine Learning Algorithms and Feature Selection Techniques for Clinical and Paraclinical Attributes: A Comparative Evaluation J. Diabetes Res. (IF 4.3) Pub Date : 2023-6-26 Antonio García-Domínguez, Carlos E. Galván-Tejada, Rafael Magallanes-Quintanar, Hamurabi Gamboa-Rosales, Irma González Curiel, Jesús Peralta-Romero, Miguel Cruz
The development of medical diagnostic models to support healthcare professionals has witnessed remarkable growth in recent years. Among the prevalent health conditions affecting the global population, diabetes stands out as a significant concern. In the domain of diabetes diagnosis, machine learning algorithms have been widely explored for generating disease detection models, leveraging diverse datasets
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Short-Term Effect of Continuous Subcutaneous Insulin Infusion and Multiple Daily Injection in Perioperative Patients with Type 2 Diabetes Mellitus J. Diabetes Res. (IF 4.3) Pub Date : 2023-6-23 Wei Song, Jianxuan Wen, Jinming Zhang, Meng Luo, Yue Hu, Yu Zhang, Guanjie Fan, Ling Zhao
Background. Hyperglycemia is common and difficult to control in perioperative patients with type 2 diabetes mellitus (T2DM), which impacts their prognosis after operation. Our study investigated the short-term effect of continuous subcutaneous insulin infusion (CSII) and multiple daily injection (MDI) in perioperative T2DM patients using the data envelopment analysis (DEA). Methods. T2DM patients ()
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Association of Polycyclic Aromatic Hydrocarbons Urine Metabolites with Type 1 Diabetes J. Diabetes Res. (IF 4.3) Pub Date : 2023-6-23 Roya Kelishadi, Silva Hovsepian, Mohammad Mehdi Amin, Nafiseh Mozafarian, Sara Sedaghat, Mahin Hashemipour
Purpose. Polycyclic aromatic hydrocarbons (PAHs) are believed to be a possible factor in the development of cancer, ischemic heart disease, obesity, and cardiovascular disease. The objective of this study was to explore the association between certain metabolites of urinary PAH and type 1 diabetes (T1D). Methods. In Isfahan City, a case-control study was carried out involving 147 T1D patients and an
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Bone Mineral Density in Adult Patients with Type 1 Diabetes Mellitus Assessed by Both DXA and QCT J. Diabetes Res. (IF 4.3) Pub Date : 2023-6-15 Eleftheria Barmpa, Spyridon Karamagkiolis, Stelios Tigas, Parthena Navrozidou, Marianna Vlychou, Ioannis Fezoulidis, Georgios N. Koukoulis, Alexandra Bargiota
Purpose. Bone mineral density (BMD) was measured in uncomplicated young adult patients with type 1 diabetes mellitus (T1DM) and sex- and age-matched controls, using both dual X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) to investigate their diagnostic ability in detecting abnormal values in these patients. Methods. 118 patients with T1DM (65 females, mean age years) and 94
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Association between Severity of Diabetic Retinopathy and Cardiac Function in Patients with Type 2 Diabetes J. Diabetes Res. (IF 4.3) Pub Date : 2023-6-7 YanYan Chen, MengYing Li, Yi Wang, JianFang Fu, XiangYang Liu, Ying Zhang, LiWen Liu, ShengJun Ta, ZuoWei Lu, ZePing Li, Jie Zhou, XiaoMiao Li
Background. The purpose of this research was to assess the relationship between the severity of diabetic retinopathy (DR) and indexes of left ventricle (LV) structure and function in type 2 diabetes mellitus (T2DM). Methods. Retrospective analysis of 790 patients with T2DM and preserved LV ejection fraction. Retinopathy stages were classified as no DR, early nonproliferative DR, moderate to severe