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Comprehensive long-read sequencing analysis discloses the transcriptome features of Papillary Thyroid Microcarcinoma. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-12-01 Yanqiang Wang,Binbin Zou,Yanyan Zhang,Jin Zhang,Shujing Li,Bo Yu,Zhekun An,Lei Li,Siqian Cui,Yutong Zhang,Jiali Yao,Xiuzhi Shi,Jing Liu
CONTEXT Papillary Thyroid Microcarcinoma (PTMC) is the most common type of thyroid cancer. It had been approved that lymph node metastasis was associated with poor prognosis in PTMC patients. OBJECTIVE We aim to characterize Papillary Thyroid Microcarcinoma (PTMC) transcriptome landscape and identify the candidate transcripts that associated with lateral neck lymph node metastasis of PTMC. METHODS
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Characteristics and risk of diabetes in people with rare glucose response curve during an oral glucose tolerance test. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-12-01 Yukako Tatsumi,Yoshihiro Miyamoto,Kei Asayama,Michihiro Satoh,Naomi Miyamatsu,Yuko Ohno,Hajime Ikei,Takayoshi Ohkubo
CONTEXT Existing differences in persons with lower 30- or 60-min plasma glucose (PG) levels during 75-g oral glucose tolerance test (OGTT) than fasting PG remain unclear. OBJECTIVE To clarify the characteristics of persons whose PG levels decrease after glucose administration during OGTT and their risk of incidence of diabetes in a Japanese general population. METHOD In this cohort study, a total of
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Neuropsychiatric adverse effects of synthetic glucocorticoids: A systematic review and meta-analysis. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-12-01 Anne-Sophie C A M Koning,Merel van der Meulen,Daphne Schaap,Djaina D Satoer,Christiaan H Vinkers,Elisabeth F C van Rossum,Wouter R van Furth,Alberto M Pereira,Onno C Meijer,Olaf M Dekkers
BACKGROUND Synthetic glucocorticoids are widely used among patients suffering from a wide range of diseases. Glucocorticoids are very efficacious, but can be accompanied by neuropsychiatric adverse effects. This systematic review and meta-analysis assesses and quantifies the proportion of different neuropsychiatric adverse effects in patients using synthetic glucocorticoids. METHODS Six electronic
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Defective Visceral Adipose Tissue Adaptation in Gestational Diabetes Mellitus. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-30 Colm J McElwain,Samprikta Manna,Andrea Musumeci,Isaac Sylvester,Chloé Rouchon,Anne Marie O'Callaghan,Mustafa Abdalla Bakhit Ebad,Fergus P McCarthy,Cathal M McCarthy
CONTEXT Gestational diabetes mellitus (GDM) is a complex obstetric condition affecting localised glucose metabolism resulting in systemic metabolic dysfunction. OBJECTIVE This cross-sectional study aimed to explore visceral adipose tissue (VAT) as an integral contributor to GDM, focusing on elucidating the specific contribution of obesity and GDM pathology to maternal outcomes. METHODS Fifty-six nulliparous
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Exercise-induced changes in central adiposity during a RCT: Effect of exercise dose and associations with compensation. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-29 James L Dorling,John W Apolzan,Neil M Johannsen,Diana M Thomas,Christoph Höchsmann,Daniel S Hsia,Corby K Martin
CONTEXT Exercise can decrease central adiposity, but the effect of exercise dose and the relationship between central adiposity and exercise-induced compensation is unclear. OBJECTIVE Test the effect of exercise dose on central adiposity change and the association between central adiposity and exercise-induced weight compensation. METHODS In this ancillary analysis of a 6-month randomized controlled
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Clinical Factors Affecting Daily Dosage of Desmopressin Orally Disintegrating Tablets in Arginine Vasopressin Deficiency. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-29 Yoshitomo Hoshino,Kosuke Inoue,Sara Ikeda,Yukiko Goshima,Keita Tatsushima,Noriaki Fukuhara,Mitsuo Okada,Hiroshi Nishioka,Shozo Yamada,Yasuhiro Takeuchi,Akira Takeshita
BACKGROUND Desmopressin orally disintegrating tablets (ODTs) are widely used to treat arginine vasopressin deficiency (AVP-D). However, limited information is available on the dosage regimen; the dosage for each patient is selected based on their response to the initiation dose. OBJECTIVE To investigate the relationships between clinical characteristics and the daily dose of ODTs and to identify factors
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Erythrocytosis Is Rare With Exogenous Testosterone in Gender-Affirming Hormone Therapy. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-27 Nithya Krishnamurthy,Daniel J Slack,Moira Kyweluk,Olivia Cullen,Jerrica Kirkley,Joshua D Safer
CONTEXT Studies have found a variable incidence of erythrocytosis among people using testosterone as part of gender-affirming hormone therapy (GAHT). OBJECTIVE To examine the effect of using exogenous testosterone as GAHT on hematocrit in a large North American cohort. METHODS We conducted a cross-sectional analysis of testosterone and hematocrit laboratory values in 6670 patients who were prescribed
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Surgical versus non-surgical management for pituitary apoplexy. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-25 Julio Abucham
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Clinical Characteristics of Malignant Phosphaturic Mesenchymal Tumor causing Tumor Induced Osteomalacia. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-25 Veronica Abate,Anita Vergatti,Gianpaolo De Filippo,Vincenzo Damiano,Ciro Menale,Lanfranco D'Elia,Domenico Rendina
PURPOSE Tumor induced osteomalacia (TIO) is a rare paraneoplastic syndrome usually caused by over-secretion of Fibroblast Growth Factors 23 (FGF23) from phosphaturic mesenchimal tumour (PMT). PMT are usually benign neoplasms but some of them show malignant characteristics. Aim of this study was to compare the clinical characteristics of benign and malignant PMT inducing TIO. METHODS On 31th March 2023
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Role of the degree of vascular invasion in predicting prognosis of follicular thyroid carcinoma. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-25 Haruhiko Yamazaki,Kiminori Sugino,Ryohei Katoh,Kenichi Matsuzu,Wataru Kitagawa,Mitsuji Nagahama,Yasushi Rino,Aya Saito,Koichi Ito
OBJECTIVE The present study investigated the prognostic factors for follicular thyroid carcinoma (FTC) with the incorporation of the histologic subtype and degree of vascular invasion (VI). PATIENTS The records of 474 patients with FTC confirmed by surgical specimens at Ito Hospital from January 2005 to December 2014 were reviewed in this retrospective cohort study. The Cox proportional hazard model
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Alpha-cell secretion across the spectrum of glucose tolerance. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-24 Marzieh Salehi
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Gonadotropin-Releasing Hormone Agonists and Bone Density in Congenital Adrenal Hyperplasia: A Call for Further Research. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-24 Priyanka Bakhtiani
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Checkpoint inhibitor associated autoimmune diabetes mellitus is characterised by C-peptide loss and pancreatic atrophy. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-24 Linda Wu,Matteo Salvatore Carlino,David Alexander Brown,Georgina Venetia Long,Roderick Clifton-Bligh,Rhiannon Mellor,Krystal Moore,Sarah Christina Sasson,Alexander Maxwell Menzies,Venessa Tsang,Jenny Elizabeth Gunton
OBJECTIVE To conduct a multi-centre case series characterising the clinical characteristics at presentation and pancreatic volume changes of patients with checkpoint inhibitor associated autoimmune diabetes (CIADM). RESEARCH DESIGN AND METHODS Electronic medical records were reviewed with 36 consecutive patients identified with CIADM, as defined by: i) previous immune checkpoint inhibitor (ICI) therapy;
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Correction to: "Critical Approach to Hypothyroid Patients With Persistent Symptoms". J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-23
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Alternative approach to BIPSS in the differential diagnosis of ACTH-dependent Cushing's syndrome. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-23 Mônica Gadelha,Luiz Eduardo Wildemberg
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Development of a new model of insulin sensitivity in patients with type 2 diabetes and association with mortality. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-22 Stefano Ciardullo,Alessandro Roberto Dodesini,Giuseppe Lepore,Anna Corsi,Cristiana Scaranna,Gianluca Perseghin,Roberto Trevisan
CONTEXT Despite being one of the major drivers of diabetes incidence, the degree of insulin resistance in patients with type 2 diabetes (T2D) is not usually evaluated in clinical practice or in large epidemiologic studies. OBJECTIVE To identify a model of insulin sensitivity using widely available clinical and laboratory parameters in patients with T2D and evaluate its association with all-cause and
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Letter to the Editor from Tayek and Umpierrez: "New Onset or Stress Hyperglycemia and Hospital Mortality Risk". J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-22 John A Tayek,Guillermo E Umpierrez
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Skeletal muscle gene expression signatures of obese high- and low- responders to endurance exercise training. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-21 Leona Kovac,Thomas Goj,Meriem Ouni,Martin Irmler,Markus Jähnert,Johannes Beckers,Martin Hrabe de Angelis,Andreas Peter,Anja Moller,Andreas L Birkenfeld,Cora Weigert,Annette Schürmann
CONTEXT Exercise training is known to improve glucose tolerance and reverse insulin resistance in persons with obesity. However, some individuals fail to improve or even decline in their clinical traits following exercise intervention. OBJECTIVE This study focused on gene expression and DNA methylation signatures in skeletal muscle of low- (LRE) and high-responders (RES) to 8 weeks of supervised endurance
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Approach to the patient with raised thyroid hormones and non-suppressed TSH. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-21 Carla Moran,Nadia Schoenmakers,David Halsall,Susan Oddy,Greta Lyons,Sjoerd van den Berg,Mark Gurnell,Krishna Chatterjee
Measurement of free thyroid hormones (TH) and thyrotropin (TSH) using automated immunoassays is central to the diagnosis of thyroid dysfunction. Using illustrative cases, we describe a diagnostic approach to discordant thyroid function tests, focusing on entities causing elevated free thyroxine (FT4) and/or free triiodothyronine (FT3) measurements with non-suppressed TSH levels. Different types of
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Effectiveness of Continuous Glucose Monitoring on Metrics of Glycemic Control in Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis of Randomized Controlled Trials. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-21 Stacey Uhl,Anuja Choure,Benjamin Rouse,Aggee Loblack,Peter Reaven
PURPOSE To provide a systematic review and meta-analysis synthesizing the findings of randomized controlled trials (RCTs) of continuous glucose monitors (CGMs) in the management of adults with type 2 diabetes mellitus (T2DM) on glucose control and clinical outcomes. METHODS MEDLINE, Embase, and Cochrane were searched for RCTs that assessed the effectiveness of real-time CGM (rt-CGM) or flash CGM (FGM)
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Association of lifestyle intervention with risk for cardiovascular events differs by level of glycated hemoglobin. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-18 Michael P Bancks,Scott J Pilla,Ashok Balasubramanyam,Hsin-Chieh Yeh,Karen C Johnson,Joseph Rigdon,Lynne E Wagenknecht,Mark A Espeland
PURPOSE We reevaluated the Action for Health in Diabetes (Look AHEAD) intensive lifestyle intervention (ILI), to assess whether the effect of ILI on cardiovascular disease (CVD) prevention differed by baseline glycated hemoglobin (HbA1c). METHODS Look AHEAD randomized 5145 adults, aged 45-76 years, with type 2 diabetes and overweight/obesity, to ILI or a diabetes support and education (DSE) control
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Pubertal girls with overweight/obesity have higher androgen levels - can metabolomics tell us why? J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-18 Madison E Calvert,Samantha A Molsberry,Kirsten E Overdahl,Alan K Jarmusch,Natalie D Shaw
CONTEXT Pubertal girls with higher total body fat (TBF) demonstrate higher androgen levels. The cause of this association is unknown but is hypothesized to relate to insulin resistance. OBJECTIVE To investigate the association between higher TBF and higher androgens in pubertal girls using untargeted metabolomics. METHODS Serum androgens were determined using a quantitative mass spectrometry-based
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The multi-biomarker acro-TIME score predicts fg-SRLs response: preliminary results of a retrospective acromegaly cohort. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-17 Sabrina Chiloiro,Rossana Moroni,Antonella Giampietro,Flavia Angelini,Marco Gessi,Liverana Lauretti,Pier Paolo Mattogno,Rosalinda Calandrelli,Tommaso Tartaglione,Angela Carlino,Simona Gaudino,Alessandro Olivi,Guido Rindi,Laura De Marinis,Alfredo Pontecorvi,Francesco Doglietto,Antonio Bianchi
BACKGROUND The prompt control of acromegaly is a primary treatment aim, for reducing related disease morbidity and mortality. First-generation somatostatin receptor ligands (fg-SRL) are the cornerstone of medical therapies. A non-negligible number of patients do not respond to this treatment. Several predictors of fg-SRL response were identified, but a -comprehensive prognostic model is lacking. We
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Serum phosphorus as a driver of skeletal morbidity in fibrous dysplasia. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-17 Zubeyir Hasan Gun,Charles Osamor,Jocelyn Taylor,Xiaobai Li,Vivian Szymczuk,Alison M Boyce
CONTEXT Fibrous dysplasia (FD) results in fractures, pain, and deformities. Abnormal osteoprogenitor cells overproduce FGF23, leading to hyperphosphaturia in most patients and frank hypophosphatemia in a subset. Studies suggest hypophosphatemia is associated with increased FD-related morbidity. However, the relationship between phosphorus and skeletal complications has not been investigated, and the
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Longitudinal Associations Between Vitamin D Status and Cardiometabolic Risk Markers Among Children and Adolescents. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-17 Maike Wolters,Manuela Marron,Ronja Foraita,Charalampos Hadjigeorgiou,Stefaan De Henauw,Gabriele Eiben,Fabio Lauria,Iris Iglesia,Luis A Moreno,Dénes Molnár,Toomas Veidebaum,Wolfgang Ahrens,Rajini Nagrani
CONTEXT Vitamin D status has previously been associated with cardiometabolic risk markers in children and adolescents. In particular, it has been suggested that children with obesity are more prone to vitamin D deficiency and unfavorable metabolic outcomes compared with healthy-weight children. OBJECTIVE To conduct a longitudinal study assessing this association in children and stratify by body mass
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Risk and incidence of endocrine immune related adverse effects under checkpoint inhibitor mono or combination therapy in solid tumors: a meta-analysis of randomized controlled trials. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-15 Irfan Vardarli,Susanne Tan,Tim Brandenburg,Frank Weidemann,Rainer Görges,Ken Herrmann,Dagmar Führer
CONTEXT Few meta-analyses regarding the incidence of endocrine immune related adverse effects (eirAEs) have been published and many trials were published thereafter. OBJECTIVE To assess the risk and incidence of eirAEs of any grade and grade 3-5 by immune checkpoint inhibitor (ICI) mono or combination-therapy in solid tumors current literature was updated in this comprehensive meta-analysis. METHODS
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Glycemia and Gluconeogenesis with Metformin and Liraglutide: A Randomized Trial in Youth-onset Type 2 Diabetes. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-15 Katrina B Dietsche,Sheela N Magge,Sydney A Dixon,Faith S Davis,Andrea Krenek,Aruba Chowdhury,Lilian Mabundo,Michael Stagliano,Amber B Courville,Shanna Yang,Sara Turner,Hongyi Cai,Kannan Kasturi,Arthur S Sherman,Joon Ha,Eileen Shouppe,Mary Walter,Peter J Walter,Kong Y Chen,Robert J Brychta,Cody Peer,Yi Zeng,William Figg,Fran Cogen,D Elizabeth Estrada,Shaji Chacko,Stephanie T Chung
OBJECTIVE Elevated rates of gluconeogenesis are an early pathogenic feature of youth-onset type 2 diabetes (Y-T2D), but targeted first-line therapies are suboptimal, especially in African American (AA) youth. We evaluated glucose-lowering mechanisms of metformin and liraglutide by measuring rates of gluconeogenesis and β-cell function after therapy in AA Y-T2D. METHODS In this parallel randomized clinical
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Cardiovascular risk markers in adults with adrenal incidentaloma and mild autonomous cortisol secretion. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-15 Angela X Chen,Anjana Radhakutty,Sophie M Drake,Andrew Kiu,Campbell H Thompson,Morton G Burt
CONTEXT Many adrenal adenomas exhibit mild autonomous cortisol secretion (MACS). While MACS is associated with increased cardiovascular mortality, the underlying mechanisms are not fully defined. OBJECTIVE To investigate mechanisms that may link MACS and cardiovascular mortality in adults with adrenal adenoma. DESIGN Cross-sectional study. PATIENTS 20 adults with adrenal adenoma and MACS and 20 controls
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Effect and interactions of BRAF on lymph node metastasis in papillary thyroid carcinoma with Hashimoto's thyroiditis. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-15 Pengyu Li,Yang Liu,Tao Wei,Xiaofei Wang,Jingqiang Zhu,Rui Yang,Yanping Gong,Wanjun Zhao
OBJECTIVE The role of BRAF in papillary thyroid carcinoma (PTC) with Hashimoto's thyroiditis (HT) is unknown. We aimed to explore risk factors affecting lymph node (LN) metastasis and interaction effect of BRAF in PTC patients with HT. METHODS We retrospectively collected the data of 994 PTC patients with HT who underwent surgery at the West China Hospital. We analyzed the correlations between preoperative
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Higher plasma levels of endocannabinoids and analogues correlate with a worse cardiometabolic profile in young adults. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-15 Xinyu Di,Borja Martinez-Tellez,Elke H J Krekels,Lucas Jurado-Fasoli,Francisco J Osuna-Prieto,Lourdes Ortiz-Alvarez,Thomas Hankemeier,Patrick C N Rensen,Jonatan R Ruiz,Isabelle Kohler
BACKGROUND AND AIM The endocannabinoid system is a signalling system composed of endocannabinoids (eCBs), their receptors, and the enzymes involved in their synthesis and metabolism. Alterations in the ECS are linked to the development of cardiometabolic diseases. Here, we investigated the relationship between plasma levels of eCBs and their analogues with body composition and cardiometabolic risk
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Polycystic Ovarian Syndrome Physiologic Pathways Implicated Through Clustering of Genetic Loci. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-15 Maria I Stamou,Kirk T Smith,Hyunkyung Kim,Ravikumar Balasubramanian,Kathryn J Gray,Miriam Udler
CONTEXT Polycystic ovarian syndrome (PCOS) is a heterogeneous disorder, with disease loci identified from genome-wide association studies (GWAS) having largely unknown relationships to disease pathogenesis. OBJECTIVE To group PCOS GWAS loci into genetic clusters associated with disease pathophysiology. DESIGN/SETTING/PATIENTS OR OTHER PARTICIPANTS Cluster analysis was performed for 60 PCOS-associated
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Epigenome-wide association study shows differential DNA methylation of MDC1, KLF9 and CUTA in autoimmune thyroid disease. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-14 Nicole Lafontaine,Christopher J Shore,Purdey J Campbell,Benjamin H Mullin,Suzanne J Brown,Vijay Panicker,Frank Dudbridge,Thomas H Brix,Laszlo Hegedüs,Scott G Wilson,Jordana T Bell,John P Walsh
CONTEXT Autoimmune thyroid disease (AITD) includes Graves' disease (GD) and Hashimoto's disease (HD), which often run in the same family. AITD etiology is incompletely understood: genetic factors may account for up to 75% of phenotypic variance, whereas epigenetic effects (including DNA methylation (DNAm)) may contribute to the remaining variance (e.g. why some individuals develop GD and others HD)
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Testosterone replacement therapy in Klinefelter syndrome - follow-up study associating hemostasis and RNA expression. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-14 Simon Chang,Jesper Just,Anne Skakkebæk,Emma B Johannsen,Jens Fedder,Claus H Gravholt,Anna-Marie B Münster
BACKGROUND Men with Klinefelter syndrome (KS) develop hypergonadotropic hypogonadism, are in need of testosterone replacement therapy (TRT) and present with a more than fourfold increased risk of thrombosis. TRT in KS has the potential to modify thrombotic risk, but data are scarce. AIM To assess effects of 18 months TRT on hemostasis in KS and identify genes associated with the prothrombotic phenotype
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Discontinuation of drug treatment in Cushing's disease not cured by pituitary surgery. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-14 Adel Ghalawinji,Lucas Drezet,Philippe Chaffanjon,Marie Muller,Nathalie Sturm,Anna Simiand,Arnaud Lazard,Emmanuel Gay,Olivier Chabre,Justine Cristante
OBJECTIVE When transsphenoidal surgery (TSS) doesn't cure Cushing's disease (CD), four treatments are available: drug treatment (DT); second TSS (2nd TSS); bilateral adrenalectomy (BA); pituitary radiotherapy (PR). DT is attractive but supposes long-term continuation, which we aimed to evaluate. DESIGN AND METHODS Retrospective study, in a center prioritizing 2nd TSS, of 36 patients, including 19 with
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Modification effects of albuminuria on the association between kidney function and development of anemia in diabetes. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-13 Akira Okada,Satoko Yamaguchi,Takahiro Imaizumi,Koji Oba,Kayo Ikeda Kurakawa,Toshimasa Yamauchi,Takashi Kadowaki,Masaomi Nangaku
INTRODUCTION Previous studies failed to adjust for estimated glomerular filtration rate (eGFR) in evaluating the association between albuminuria and anemia development, and we aimed to investigate whether albuminuria independently affects anemia development. METHODS We conducted a retrospective cohort study and retrospectively identified adults with diabetes from a Japanese nationwide clinical database
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Renal cortical glucose uptake is decreased in insulin resistance and correlates inversely with serum free-fatty acids. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-13 Eleni Rebelos,Andrea Mari,Miikka-Juhani Honka,Laura Pekkarinen,Aino Latva-Rasku,Sanna Laurila,Johan Rajander,Paulina Salminen,Hidehiro Iida,Ele Ferrannini,Pirjo Nuutila
CONTEXT Studies on human renal metabolism are scanty. Nowadays, functional imaging allows the characterization of renal metabolism in a non-invasive manner. We have recently demonstrated that [18F]FDG-PET can be used to analyze renal glucose uptake rates (GU), and that the renal cortex is an insulin sensitive tissue. OBJECTIVE To confirm that renal GU is decreased in people with obesity, and to test
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Reduced Quality of Life in Former Androgen Users: An Evolving Public-Health Concern. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-13 Harrison G Pope,Gen Kanayama
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Vitamin D status during adolescence and the impact of lifestyle changes - two years follow-up from the Fit Futures Study. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-13 Johanna Öberg,Rolf Jorde,Bjørg Almås,Christopher Sivert Nielsen,Thomas Alexander Gerds,Kevin D Cashman,Guri Grimnes
AIM The aims of this study were to investigate changes in vitamin D status during two years in adolescence, and whether lifestyle changes were associated with serum 25-hydroxyvitamin D (s-25(OH)D) at follow-up. METHODS Fit Futures is a longitudinal study at 69°N in Norway. Participants had their s-25(OH)D levels analysed in their first and third year of upper secondary school (median age 16 and 18
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Impact of Free Fatty Acids on Vascular Insulin Responses Across the Arterial Tree: a Randomized Crossover Study. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-10 Kaitlin M Love,Linda A Jahn,Lee M Hartline,Kevin W Aylor,Zhenqi Liu
PURPOSE To elucidate the impact of elevated free fatty acids (FFAs) on insulin action across the arterial tree and define the relationship among insulin actions in the different arterial segments. METHODS This randomized crossover study assigned healthy lean adults to two separate admissions with euglycemic insulin clamp superimposed for the final 120-mins of 5-hr lipid or matched-volume saline infusion
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Time to Benefit of Surgery vs. Targeted Medical Therapy for Patients with Primary Aldosteronism: A Meta-analysis. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-08 Sunil Samnani,Irena Cenzer,Gregory A Kline,Sei J Lee,Gregory L Hundemer,Caitlin McClurg,Janice L Pasieka,W John Boscardin,Paul E Ronksley,Alexander A Leung
CONTEXT Primary aldosteronism (PA) is one of the most common causes of secondary hypertension, but the comparative outcomes of targeted treatment remain unclear. OBJECTIVES To compare the clinical outcomes in patients treated for primary aldosteronism over time. DATA SOURCES Medline and EMBASE. STUDY SELECTION Original studies reporting incidence of mortality, major adverse cardiovascular outcomes
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Leptin and Insulin Sensitivity: Endogenous Signals of Metabolic Homeostasis. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-07 Sam Dagogo-Jack
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Long-term Cardiovascular Disease After Adverse Pregnancy Outcomes. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-02 Emily A Rosenberg,Ellen W Seely
Cardiovascular disease (CVD) is the leading cause of death among women. Adverse pregnancy outcomes (APOs) are cardiovascular risk factors that are unique to women and include gestational diabetes (GDM) and preeclampsia. While these risk factors emerge during the reproductive years and allow for early risk reduction counseling, they are often overlooked and not elicited by providers. This mini-review
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Metabolic profiles of type 2 diabetes and their association with renal complications. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-02 Shen Li,Mengxuan Cui,Yingshu Liu,Xuhan Liu,Lan Luo,Wei Zhao,Xiaolan Gu,Linfeng Li,Chao Liu,Lan Bai,Di Li,Bo Liu,Defei Che,Xinyu Li,Yao Wang,Zhengnan Gao
CONTEXT The components of metabolic syndrome (MetS) are interrelated and associated with renal complications in patients with type 2 diabetes (T2D). AIMS We aimed to reveal prevalent metabolic profiles in patients with T2D and identify which metabolic profiles were risk markers for renal progression. METHODS A total of 3556 participants with T2D from a hospital (derivation cohort) and 931 participants
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Serum Tsukushi level is associated with the severity of liver fibrosis independent of type 2 diabetes. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-02 Sum Lam,Chi-Ho Lee,Carol H Y Fong,Ying Wong,Sammy W M Shiu,Lung-Yi Mak,Man-Fung Yuen,Karen S L Lam,Kathryn C B Tan
BACKGROUND & AIMS Tsukushi (TSK) is a recently identified hepatokine and we aimed to investigate the association between systemic TSK and the severity of non-alcoholic fatty liver disease (NAFLD) in subjects with and without type 2 diabetes mellitus (DM). METHODS 393 DM and 289 without DM individuals were recruited for transient elastography assessment to determine liver steatosis and fibrosis. Serum
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Current Recommended Estrogen Dosing for Pubertal Induction in Turner Syndrome Results in Normal Uterine Growth. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-02 Faith Lindsay Mart,Iris Gutmark-Little,Tara Streich-Tilles,Andrew T Trout,Jane Khoury,Katherine Bowers,Lori Casnellie,Philippe Backeljauw
CONTEXT Most individuals with Turner syndrome (TS) require estrogen for pubertal induction. Current estrogen dosing guidelines are based on expert consensus opinion. OBJECTIVE Evaluate if current international guidelines for estrogen dosing during pubertal induction of individuals with TS result in normal uterine growth. We hypothesized that uterine size in individuals with TS who reached adult estrogen
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Hemoglobin Glycation Index, A Novel Risk Factor for Incident Chronic Kidney Disease in Apparently Healthy Population. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-01 Yasuto Nakasone,Takahiro Miyakoshi,Takahiro Sakuma,Shigeru Toda,Yosuke Yamada,Tomomasa Oguchi,Kazuko Hirabayashi,Hideo Koike,Koh Yamashita,Toru Aizawa
CONTEXT Chronic kidney disease (CKD) is a world-wide health problem. Recent literature has shown an association of hemoglobin glycation index (HGI) and CKD in patients with dysglycemia. OBJECTIVE The aim of this study was to reveal impact of HGI as a predictor for incident CKD in the general population. METHODS CKD was defined as dipstick proteinuria or estimated glomerular rate (eGFR) < 60 ml/min/1
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High frequency of recessive WFS1 mutations among Indian children with islet antibody-negative type 1 diabetes. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-01 Jayakrishnan C Menon,Pratibha Singh,Archana Archana,Preeti Singh,Medha Mittal,Uma Kanga,Kausik Mandal,Anju Seth,Vijayalakshmi Bhatia,Preeti Dabadghao,Siddhnath Sudhanshu,Atul Garg,Ruchira Vishwakarma,Aditya Narayan Sarangi,Shivendra Verma,Surya Kumar Singh,Eesh Bhatia
BACKGROUND While the frequency of islet antibody-negative (idiopathic) type 1 diabetes mellitus (T1DM) is reported to be increased in Indian children, its aetiology is not studied. We investigated the role of monogenic diabetes in the causation of islet antibody-negative T1DM. METHODS We conducted a multicentre, prospective, observational study of 169 Indian children (age 1-18 years) with recent-onset
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"Lifestyle Intervention with Smartphone app and isCGM for People at High Risk of Type 2 Diabetes: Randomized Trial". J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-01 Masaru Kitazawa,Yasunaga Takeda,Mariko Hatta,Chika Horikawa,Takaaki Sato,Taeko Osawa,Masahiro Ishizawa,Hiroshi Suzuki,Yasuhiro Matsubayashi,Kazuya Fujihara,Takaho Yamada,Hirohito Sone
AIMS Although conventional interventions for people at high risk of developing type 2 diabetes are usually conducted face-to-face, such interventions are burdensome for healthcare providers. We developed a lifestyle intervention program combining lifestyle coaching via a smartphone application augmented by intermittently scanned continuous glucose monitoring (isCGM) without burdening healthcare providers
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Sex-Specific Obesity and Cardiometabolic Disease Risks in Low- and Middle-Income Countries: A Meta-Analysis Involving 3 916 276 Individuals. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-01 Thaís Rocha,Eka Melson,Javier Zamora,Borja Manuel Fernandez-Felix,Wiebke Arlt,Shakila Thangaratinam
CONTEXT There is limited knowledge about the disparities between the sexes in obesity prevalence and associated cardiovascular complications in low- and middle-income countries (LMICs). OBJECTIVE We undertook a systematic review and meta-analysis to assess sex-specific disparities in the prevalence of obesity and cardiometabolic diseases in LMICs, the burden in women, and variations by region, country's
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Temporal trends in distal symmetric polyneuropathy in type 2 diabetes: The Fremantle Diabetes Study. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-01 Wendy A Davis,Emma Hamilton,Timothy M E Davis
CONTEXT Macrovascular outcomes in type 2 diabetes have improved over recent decades. There are no equivalent distal symmetric polyneuropathy (DSPN) data. OBJECTIVE To characterize temporal changes in DSPN prevalence and incidence rates (IRs) in community-based Australians. DESIGN Observational study. SETTING Urban population. PARTICIPANTS Participants with type 2 diabetes from the Fremantle Diabetes
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Effect of burosumab on muscle function and strength, and rates of ATP synthesis in skeletal muscle in adults with XLH. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-01 Karl L Insogna,Rebecca Sullivan,Stephen Parziale,Yanhong Deng,Diana Carrano,Christine Simpson,Sylvie Dufour,Thomas Carpenter,Kitt Falk Petersen
CONTEXT In clinical trials, burosumab ameliorates symptoms of pain, fatigue and stiffness and improves performance on certain muscle function studies in patients with XLH. OBJECTIVE Determine if burosumab increases ATP synthesis in skeletal muscle of treatment-naïve adults with XLH. If so, whether that correlates with improved muscle function. METHODS Ten untreated, symptomatic adults with XLH had
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Dasiglucagon for the treatment of congenital hyperinsulinism: a randomised phase 3 trial in infants and children. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-01 Paul S Thornton,Diva D De Leon,Susann Empting,David Zangen,David M Kendall,Sune Birch,Eva Bøge,Jelena Ivkovic,Indraneel Banerjee
CONTEXT Congenital hyperinsulinism (CHI) is characterised by dysregulated insulin secretion causing hypoglycaemia and consequent brain damage. Dasiglucagon is a glucagon analogue under investigation to treat CHI. OBJECTIVE To evaluate the efficacy and safety of dasiglucagon delivered via continuous subcutaneous infusion to children with CHI and persistent hypoglycaemia as add-on to standard of care
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Letter to the Editor from Ye and Li: "Association of Circulating Very Long Chain Saturated Fatty Acids with Cardiovascular Mortality in NHANES 2015-2016". J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-11-01 Jiayi Ye,Ka Li
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Association between advanced glycation end products and sarcopenia: The mediating role of osteoporosis. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-10-31 Xingyu Zhang,Xiaoyu Chen,Shengjie Li,Mengze Gao,Peipei Han,Liou Cao,Jing Gao,Qiongying Tao,Jiayi Zhai,Dongyu Liang,Li Qin,Qi Guo
BACKGROUND Advanced glycation end products (AGEs) are a group of molecules formed through non-enzymatic reactions. These compounds were associated to several age-related diseases, including sarcopenia and osteoporosis. OBJECTIVE To investigate the relationships between AGEs, osteoporosis, and sarcopenia in community-dwelling older adults. MATERIALS AND METHODS This cross-sectional study included 1991
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Efficacy and Safety of Teprotumumab in Thyroid Eye Disease Patients with Long Duration and Low Disease Activity. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-10-31 Raymond S Douglas,Steven Couch,Sara T Wester,Brian T Fowler,Catherine Y Liu,Prem S Subramanian,Rosa Tang,Quang T Nguyen,Robi N Maamari,Shoaib Ugradar,Kate Hsu,Michael Karon,Marius N Stan
CONTEXT Early inflammatory thyroid eye disease (TED) can lead to symptomatic chronic disease including disabling proptosis. Teprotumumab, an IGF-1 receptor inhibitor, previously demonstrated efficacy in acute, high-inflammation TED trials. OBJECTIVE We present data from the first placebo-controlled trial with teprotumumab in chronic/low disease activity TED. DESIGN This was a randomized double-masked
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Association of Urine Albumin-to-Creatinine Ratio with Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-10-31 Cheng Zeng,Maojun Liu,Yifeng Zhang,Simin Deng,Ying Xin,Xinqun Hu
CONTEXT The urinary albumin-to-creatinine ratio (UACR) is a widely used indicator of albuminuria and has predictive value for adverse cardiovascular events. OBJECTIVE To evaluate the correlation between the UACR and the risk of developing major adverse cardiovascular events (MACEs) and total mortality in patients with type 2 diabetes mellitus (T2DM). METHODS This post-hoc analysis included 10,171 participants
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Nonalcoholic Fatty Liver Disease and the Risk of Thyroid Cancer Among Young Adults in South Korea. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-10-31 Hyemi Kwon,Kyung-Do Han,Sun Joon Moon,Se Eun Park,Eun-Jung Rhee,Won-Young Lee
CONTEXT Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Obesity and metabolic syndrome are known risk factors for thyroid cancer. OBJECTIVE We investigated the association between NAFLD and thyroid cancer risk in young adults. METHODS This nationwide cohort study included 1 135 967 participants aged 20 to 39 years who underwent 4 consecutive health screenings
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Ectopic Cervical Thymoma in a Patient Diagnosed with Graves Disease: A Systematic Literature Review. J. Clin. Endocrinol. Metab. (IF 5.8) Pub Date : 2023-10-28 Samuel Nemiroff,Raymond Chai,Jun Fan,Ilana Ramer-Bass
Thymomas are benign thymic epithelial neoplasms, rarely found outside the anterior mediastinum. Although hyperthyroid states have been associated with thymic hyperplasia, only 3 thymoma cases have been previously reported in patients with Graves Disease (GD), all within the anterior mediastinum. Here, we report a case of ectopic cervical thymoma in a 22-year-old female patient previously treated for