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Dectin-2 Deficiency Promotes Pro-inflammatory Cytokine Release from Macrophages and Impairs Insulin Secretion. Endocrinology (IF 4.8) Pub Date : 2023-12-01 Masamichi Fujita,Takashi Miyazawa,Keiichiro Uchida,Naohiro Uchida,Shojiro Haji,Seiichi Yano,Norifusa Iwahashi,Tomomi Hatayama,Shunsuke Katsuhara,Shintaro Nakamura,Yukina Takeichi,Maki Yokomoto-Umakoshi,Yasutaka Miyachi,Ryuichi Sakamoto,Yoichiro Iwakura,Yoshihiro Ogawa
Pancreatic islet inflammation plays a crucial role in the etiology of type 2 diabetes (T2D). Macrophages residing in pancreatic islets have emerged as key players in islet inflammation. Macrophages express a plethora of innate immune receptors that bind to environmental and metabolic cues and integrate these signals to trigger an inflammatory response that contributes to the development of islet inflammation
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Elevated Norepinephrine Stimulates Adipocyte Hyperplasia in Ovine Fetuses with Placental Insufficiency and IUGR. Endocrinology (IF 4.8) Pub Date : 2023-11-30 Rosa I Luna-Ramirez,Amy C Kelly,Miranda J Anderson,Christopher A Bidwell,Ravi Goyal,Sean W Limesand
Prevailing hypoxemia and hypoglycemia in near-term fetuses with placental insufficiency-induced intrauterine growth restriction (IUGR) chronically increases norepinephrine concentrations, which lowers adrenergic sensitivity and lipid mobilization postnatally, indicating a predisposition for adiposity. To determine adrenergic-induced responses, we examined the perirenal adipose tissue transcriptome
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Corticosteroid-binding globulin (SERPINA6) consolidates sexual dimorphism of adult rat liver. Endocrinology (IF 4.8) Pub Date : 2023-11-28 Julia N C Toews,Tristan J Philippe,Matthew Dordevic,Lesley A Hill,Geoffrey L Hammond,Victor Viau
Produced by the liver, corticosteroid-binding globulin (CBG) regulates the plasma distribution and actions of glucocorticoids. A sex difference in pituitary growth hormone secretion patterns established during puberty in rats results in increased hepatic CBG production and two-fold higher plasma corticosterone levels in females. Glucocorticoids control hepatic development and metabolic activities,
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Hindbrain adrenergic/noradrenergic control of integrated endocrine and autonomic stress responses. Endocrinology (IF 4.8) Pub Date : 2023-11-28 Sebastian A Pace,Brent Myers
Hindbrain adrenergic/noradrenergic nuclei facilitate endocrine and autonomic responses to physical and psychological challenges. Neurons that synthesize adrenaline and noradrenaline target hypothalamic structures to modulate endocrine responses while descending spinal projections regulate sympathetic function. Furthermore, these neurons respond to diverse stress-related metabolic, autonomic, and psychosocial
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Increased OCT3 Expression in Adipose Tissue With Aging: Implications for Catecholamine and Lipid Turnover and Insulin Resistance in Women. Endocrinology (IF 4.8) Pub Date : 2023-11-20 Fozia Ahmed,Milica Vranic,Susanne Hetty,Argyri Mathioudaki,Vagia Patsoukaki,Giovanni Fanni,Maria J Pereira,Jan W Eriksson
BACKGROUND Catecholamine-stimulated lipolysis is reduced with aging, which may promote adiposity and insulin resistance. Organic cation transporter 3 (OCT3), which is inhibited by estradiol (E2), mediates catecholamine transport into adipocytes for degradation, thus decreasing lipolysis. In this study, we investigated the association of OCT3 mRNA levels in subcutaneous adipose tissue (SAT) with aging
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DHT and Insulin Upregulate Secretion of the Soluble Decoy Receptor of IL-33 From Decidualized Endometrial Stromal Cells. Endocrinology (IF 4.8) Pub Date : 2023-11-20 Daniel Salamon,Dorina Ujvari,Anton Hellberg,Angelica Lindén Hirschberg
Interleukin 33 (IL-33) signaling regulates most of the key processes of pregnancy, including decidualization, trophoblast proliferation and invasion, vascular remodeling, and placental growth. Accordingly, dysregulation of IL-33, its membrane-bound receptor (ST2L, transducer of IL-33 signaling), and its soluble decoy receptor (sST2, inhibitor of IL-33 signaling) has been linked to a wide range of adverse
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A Novel Tissue-Specific Insight into Sex Steroid Fluctuations Throughout the Murine Estrous Cycle. Endocrinology (IF 4.8) Pub Date : 2023-11-20 Christian A Unger,Marion C Hope,Ahmed K Aladhami,William E Cotham,Cassidy E Socia,Barton C Rice,Deborah J Clegg,Kandy T Velázquez,Holly A LaVoie,Fiona Hollis,Reilly T Enos
Serum sex steroid levels fluctuate throughout the reproductive cycle. However, the degree to which sex steroid tissue content mimics circulating content is unknown. Understanding the flux and physiological quantity of tissue steroid content is imperative for targeted hormonal therapy development. Utilizing a gold-standard ultrasensitive liquid chromatography-mass spectrometry (LC/MS) method we determined
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Progesterone Activates the Histone Lactylation-Hif1α-glycolysis Feedback Loop to Promote Decidualization. Endocrinology (IF 4.8) Pub Date : 2023-11-20 Wei Zhao,Yue Wang,Juan Liu,Qianying Yang,Shuai Zhang,Xiao Hu,Zhicheng Shi,Zhenni Zhang,Jianhui Tian,Dapeng Chu,Lei An
Decidualization is a progesterone-dependent cellular differentiation process that is essential for establishing pregnancy. Robust activation of glycolysis and lactate synthesis during decidualization is remarkable, but their developmental functions remain largely unknown. Herein, we identify that endometrial lactate production plays a critical role in establishing local histone lactylation, a newly
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Insights into RNA N6-methyladenosine in Glucose and Lipid Metabolic Diseases and Their Therapeutic Strategies. Endocrinology (IF 4.8) Pub Date : 2023-11-20 Yifan Wu,Yuan Zeng,Yaolin Ren,Jie Yu,Qian Zhang,Xinhua Xiao
The incidence of glucose and lipid metabolism diseases, including type 2 diabetes, obesity, metabolic syndrome, and nonalcoholic fatty liver disease, is rising, which places an enormous burden on people around the world. However, the mechanism behind these disorders remains incompletely understood. N6-methyladenosine (m6A) is 1 type of posttranscriptional RNA modification, and research has shown that
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β Cell Stress and Endocrine Function During T1D: What Is Next to Discover? Endocrinology (IF 4.8) Pub Date : 2023-11-20 Celia Vived,Alexander Lee-Papastavros,Jéssica Aparecida da Silva Pereira,Peng Yi,Tara L MacDonald
Canonically, type 1 diabetes (T1D) is a disease characterized by autoreactive T cells as perpetrators of endocrine dysfunction and β cell death in the spiral toward loss of β cell mass, hyperglycemia, and insulin dependence. β Cells have mostly been considered as bystanders in a flurry of autoimmune processes. More recently, our framework for understanding and investigating T1D has evolved. It appears
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Classical Estrogen Signaling in Ciliated Epithelial Cells of the Oviduct Is Nonessential for Fertility in Female Mice. Endocrinology (IF 4.8) Pub Date : 2023-11-20 Emily A McGlade,Kalli K Stephens,Sarayut Winuthayanon,Prashanth Anamthathmakula,Michael J Holtzman,Wipawee Winuthayanon
Ciliary action performs a critical role in the oviduct (Fallopian tube) during pregnancy establishment through sperm and egg transport. The disruption of normal ciliary function in the oviduct affects oocyte pick-up and is a contributing factor to female infertility. Estrogen is an important regulator of ciliary action in the oviduct and promotes ciliogenesis in several species. Global loss of estrogen
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TSH Pulses Finely Tune Thyroid Hormone Release and TSH Receptor Transduction. Endocrinology (IF 4.8) Pub Date : 2023-11-20 Anne Guillou,Yasmine Kemkem,Chrystel Lafont,Pierre Fontanaud,Davide Calebiro,Pauline Campos,Xavier Bonnefont,Tatiana Fiordelisio-Coll,Ying Wang,Emilie Brûlé,Daniel J Bernard,Paul Le Tissier,Frederik Steyn,Patrice Mollard
Detection of circulating TSH is a first-line test of thyroid dysfunction, a major health problem (affecting about 5% of the population) that, if untreated, can lead to a significant deterioration of quality of life and adverse effects on multiple organ systems. Human TSH levels display both pulsatile and (nonpulsatile) basal TSH secretion patterns; however, the importance of these in regulating thyroid
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Fibroblast Growth Factor 23 Neutralizing Antibody Ameliorates Abnormal Renal Phosphate Handling in Sickle Cell Disease Mice. Endocrinology (IF 4.8) Pub Date : 2023-11-02 Liping Xiao,Kai Clarke,Marja M Hurley
We assessed the involvement of fibroblast growth factor 23 (FGF23) in phosphaturia in sickle cell disease (SCD) mice. Control and SCD mice were treated with FGF23 neutralizing antibody (FGF23Ab) for 24 hours. Serum ferritin was significantly increased in SCD mice and was significantly reduced in female but not male SCD mice by FGF23Ab. FGF23Ab significantly reduced increased erythropoietin in SCD kidneys
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Top-Down Proteomics of Mouse Islets With Beta Cell CPE Deletion Reveals Molecular Details in Prohormone Processing. Endocrinology (IF 4.8) Pub Date : 2023-11-02 James M Fulcher,Adam C Swensen,Yi-Chun Chen,C Bruce Verchere,Vladislav A Petyuk,Wei-Jun Qian
Altered prohormone processing, such as with proinsulin and pro-islet amyloid polypeptide (proIAPP), has been reported as an important feature of prediabetes and diabetes. Proinsulin processing includes removal of several C-terminal basic amino acids and is performed principally by the exopeptidase carboxypeptidase E (CPE), and mutations in CPE or other prohormone convertase enzymes (PC1/3 and PC2)
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Paradigm Shift in the Management of Metabolic Diseases-Next-Generation Incretin Therapy. Endocrinology (IF 4.8) Pub Date : 2023-11-02 Bo Ahrén
Recently impressive weight loss has been reported for novel incretin therapies based on dual-and triple-hormone receptor coagonists. These agents have potential as being positioned as early therapeutics for metabolic diseases for which weight loss is preferred, such as type 2 diabetes, obesity, cardiovascular diseases, and nonalcoholic liver disease. This development will change the landscape of future
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Gestational Diabetes Induced by Low Vitamin B6. Endocrinology (IF 4.8) Pub Date : 2023-11-02 Ricardo Augusto Leoni De Sousa,Ricardo Cardoso Cassilhas
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Standardized In Vitro Models of Human Adipose Tissue Reveal Metabolic Flexibility in Brown Adipocyte Thermogenesis. Endocrinology (IF 4.8) Pub Date : 2023-11-02 Cheryl Cero,Weiguo Shu,Amy L Reese,Diana Douglas,Michael Maddox,Ajeet P Singh,Sahara L Ali,Alexander R Zhu,Jacqueline M Katz,Anne E Pierce,Kelly T Long,Naris Nilubol,Raymond H Cypess,Jonathan L Jacobs,Fang Tian,Aaron M Cypess
Functional human brown and white adipose tissue (BAT and WAT) are vital for thermoregulation and nutritional homeostasis, while obesity and other stressors lead, respectively, to cold intolerance and metabolic disease. Understanding BAT and WAT physiology and dysfunction necessitates clinical trials complemented by mechanistic experiments at the cellular level. These require standardized in vitro models
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Mechanism of Arcuate Kisspeptin Neuron Synchronization in Acute Brain Slices From Female Mice. Endocrinology (IF 4.8) Pub Date : 2023-11-02 Paul G Morris,Allan E Herbison
The mechanism by which arcuate kisspeptin (ARNKISS) neurons co-expressing glutamate, neurokinin B, and dynorphin intermittently synchronize their activity to drive pulsatile hormone secretion remains unclear in females. In order to study spontaneous synchronization within the ARNKISS neuron network, acute brain slices were prepared from adult female Kiss1-GCaMP6 mice. Analysis of both spontaneous synchronizations
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Evaluation of Ex Vivo Adrenocorticotropic Hormone Responsiveness of Human Fetal Testis. Endocrinology (IF 4.8) Pub Date : 2023-11-02 Mariska A M Schröder,David Greenald,Renate Lodewijk,Antonius E van Herwaarden,Paul N Span,Fred C G J Sweep,Rod T Mitchell,Hedi L Claahsen-van der Grinten
Testicular adrenal rest tumors (TARTs), commonly occurring in males with congenital adrenal hyperplasia, may arise from chronic stimulation of adrenocorticotropic hormone (ACTH)-sensitive cells in the testes. It is not yet established whether the human fetal testis (HFT) is responsive to ACTH. To investigate this, we cultured HFT tissue with and without ACTH for up to 5 days, and quantified adrenal
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Postnatal Development and Maintenance of Functional Pituitary Gonadotrophs Is Dependent on PI4-Kinase A. Endocrinology (IF 4.8) Pub Date : 2023-11-02 Stephanie Constantin,Srdjan J Sokanovic,Yuta Mochimaru,Kosara Smiljanic,Sonja Sivcev,Rafael M Prévide,Susan Wray,Tamas Balla,Stanko S Stojilkovic
Postnatal development of functional pituitary gonadotrophs is necessary for maturation of the hypothalamic-pituitary-gonadal axis, puberty, and reproduction. Here we examined the role of PI4-kinase A, which catalyzes the biosynthesis of PI4P in mouse reproduction by knocking out this enzyme in cells expressing the gonadotropin-releasing hormone (GnRH) receptor. Knockout (KO) mice were infertile, reflecting
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A Novel Mechanism of hPRL-G129R, a Prolactin Antagonist, Inhibits Human Breast Cancer Cell Proliferation and Migration. Endocrinology (IF 4.8) Pub Date : 2023-11-02 Ruonan Li,Yu Yang,Hainan Lan,Yuesi Wang,Zihan Ge,Xingjie Liu,Yixuan Zhou,Wei Zhang,Li Xian,Hongxuan Yuan
Prolactin (PRL) and its receptor, PRLR, are closely related to the occurrence and development of breast cancer. hPRL-G129R, an hPRLR antagonist, has been found to induce apoptosis in breast cancer cells via mechanisms currently unknown. Recent studies have indicated that PRLR exhibits dual functions based on its membrane/nucleus localization. In that context, we speculated whether hPRL-G129R is a dual-function
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The Power of the Heterogeneous Stock Rat Founder Strains in Modeling Metabolic Disease. Endocrinology (IF 4.8) Pub Date : 2023-11-02 Valerie A Wagner,Katie L Holl,Karen C Clark,John J Reho,Hans-Joachim Lehmler,Kai Wang,Justin L Grobe,Melinda R Dwinell,Hershel Raff,Anne E Kwitek
Metabolic diseases are a host of complex conditions, including obesity, diabetes mellitus, and metabolic syndrome. Endocrine control systems (eg, adrenals, thyroid, gonads) are causally linked to metabolic health outcomes. N/NIH Heterogeneous Stock (HS) rats are a genetically heterogeneous outbred population developed for genetic studies of complex traits. Genetic mapping studies in adult HS rats identified
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Prolactin Inhibits or Stimulates the Inflammatory Response of Joint Tissues in a Cytokine-dependent Manner. Endocrinology (IF 4.8) Pub Date : 2023-11-02 Jose Fernando García-Rodrigo,Georgina Ortiz,Oscar Fernando Martínez-Díaz,Janette Furuzawa-Carballeda,Xarubet Ruíz-Herrera,Fernando Macias,María G Ledesma-Colunga,Gonzalo Martínez de la Escalera,Carmen Clapp
The close association between rheumatoid arthritis (RA), sex, reproductive state, and stress has long linked prolactin (PRL) to disease progression. PRL has both proinflammatory and anti-inflammatory outcomes in RA, but responsible mechanisms are not understood. Here, we show that PRL modifies in an opposite manner the proinflammatory actions of IL-1β and TNF-α in mouse synovial fibroblasts in culture
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Sustained Pituitary T3 Production Explains the T4-mediated TSH Feedback Mechanism. Endocrinology (IF 4.8) Pub Date : 2023-11-02 Alice Batistuzzo,Federico Salas-Lucia,Balázs Gereben,Miriam O Ribeiro,Antonio C Bianco
The regulation of thyroid activity and thyroid hormone (TH) secretion is based on feedback mechanisms that involve the anterior pituitary TSH and medial basal hypothalamus TSH-releasing hormone. Plasma T3 levels can be "sensed" directly by the anterior pituitary and medial basal hypothalamus; plasma T4 levels require local conversion of T4 to T3, which is mediated by the type 2 deiodinase (D2). To
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lncRNA Hnscr Regulates Lipid Metabolism by Mediating Adipocyte Lipolysis. Endocrinology (IF 4.8) Pub Date : 2023-11-02 Yi-Fan Guo,Jing-Yi Sun,Ya Liu,Zhe-Yu Liu,Yan Huang,Yuan Xiao,Tian Su
Obesity is a process of fat accumulation due to the imbalance between energy intake and consumption. Long noncoding RNA (lncRNA) Hnscr is crucial for metabolic regulation, but its roles in lipid metabolism during obesity are still unknown. In this article, we found that the expression of Hnscr gradually decreased in adipose tissues of diet-induced obese mice. Furthermore, the deletion of Hnscr promoted
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Legacy and Emerging Perfluoroalkyl and Polyfluoroalkyl Substances Regulate Steroidogenesis in the Male Gonad. Endocrinology (IF 4.8) Pub Date : 2023-11-02 Samantha Daugherty,Vanisree Mulabagal,Joel Hayworth,Benson T Akingbemi
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are widely used in a variety of industrial processes and manufacturing of consumer products. Current efforts by the manufacturing industry will limit use of long-chain or legacy PFAS represented by perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) and replace with short-chain or emerging PFAS such as perfluorobutanoic acid (PFBA)
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Ghrelin Action in the PVH of Male Mice: Accessibility, Neuronal Targets, and CRH Neurons Activation. Endocrinology (IF 4.8) Pub Date : 2023-09-23 Gimena Fernandez,Pablo N De Francesco,María P Cornejo,Agustina Cabral,Julieta P Aguggia,Victor J Duque,Nilufer Sayar,Sonia Cantel,Juan I Burgos,Jean-Alain Fehrentz,Rodrigo Rorato,Deniz Atasoy,André S Mecawi,Mario Perello
The hormone ghrelin displays several well-characterized functions, including some with pharmaceutical interest. The receptor for ghrelin, the growth hormone secretagogue receptor (GHSR), is expressed in the hypothalamic paraventricular nucleus (PVH), a critical hub for the integration of metabolic, neuroendocrine, autonomic, and behavioral functions. Here, we performed a neuroanatomical and functional
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Adipocyte Subpopulations Mediate Growth Hormone-induced Lipolysis and Glucose Tolerance in Male Mice. Endocrinology (IF 4.8) Pub Date : 2023-09-23 Jun Huang,Sohana Siyar,Rita Sharma,Isabella Herrig,Lauren Wise,Spencer Aidt,Edward List,John J Kopchick,Vishwajeet Puri,Kevin Y Lee
In adipose tissue, growth hormone (GH) stimulates lipolysis, leading to an increase in plasma free fatty acid levels and a reduction in insulin sensitivity. In our previous studies, we have found that GH increases lipolysis by reducing peroxisome proliferator-activated receptor γ (PPARγ) transcription activity, leading to a reduction of tat-specific protein 27 (FSP27, also known as CIDEC) expression
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Synergistic Combinations of Gut- and Pancreas-Hormone-Based Therapies: Advancements in Treatments for Metabolic Diseases. Endocrinology (IF 4.8) Pub Date : 2023-09-23 Sulayman Aslan Lyons,Jacqueline Leah Beaudry
Metabolic diseases, such as obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease, and liver disease, have become increasingly prevalent around the world. As an alternative to bariatric surgery, glucagon-like peptide 1 (GLP-1) receptor agonists have been at the forefront of weight loss medication to combat these metabolic complications. Recently, there has been an exciting rapid emergence
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Mast Cell Dynamics in the Ovary Are Governed by GnRH and Prolactin. Endocrinology (IF 4.8) Pub Date : 2023-09-23 Titaree Laoharatchatathanin,Duangjai Rieanrakwong,Yoshinori Hatsugai,Ryota Terashima,Tomohiro Yonezawa,Shiro Kurusu,Mitsumori Kawaminami
Gonadotrophin releasing hormone (GnRH) facilitates the migration of mast cells (MCs) into the involuting mammary gland. As GnRH is also expressed in the ovary, we examined changes in ovarian MCs. MCs in the ovary were mainly in interstitial tissue and their number increased during the estrous cycle to produce 2 peaks, one at diestrus 2 (20:00 hours) and another at proestrus (17:00 hours). Laser microdissection
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Fasting Modulates GABAergic Synaptic Transmission to Arcuate Kisspeptin Neurons in Female Mice. Endocrinology (IF 4.8) Pub Date : 2023-09-23 Naira da Silva Mansano,Henrique Rodrigues Vieira,Roberta Araujo-Lopes,Raphael Escorsim Szawka,Jose Donato,Renata Frazao
It is well-established that the hypothalamic-pituitary-gonadal (HPG) axis is suppressed due to negative energy balance. However, less information is available on whether kisspeptin neuronal activity contributes to fasting-induced responses. In the present study, female and male mice were fasted for 24 hours or provided food ad libitum (fed group) to determine whether acute fasting is sufficient to
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The Neuroendocrine Impact of Acute Stress on Synaptic Plasticity. Endocrinology (IF 4.8) Pub Date : 2023-09-23 Raoni Conceição Dos-Santos,Brook L W Sweeten,Claire E Stelly,Jeffrey G Tasker
Stress induces changes in nervous system function on different signaling levels, from molecular signaling to synaptic transmission to neural circuits to behavior-and on different time scales, from rapid onset and transient to delayed and long-lasting. The principal effectors of stress plasticity are glucocorticoids, steroid hormones that act with a broad range of signaling competency due to the expression
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Lesions of KNDy and Kiss1R Neurons in the Arcuate Nucleus Produce Different Effects on LH Pulse Patterns in Female Sheep. Endocrinology (IF 4.8) Pub Date : 2023-09-23 Robert L Goodman,Aleisha M Moore,Kayla Onslow,Stanley M Hileman,Steve L Hardy,Elizabeth C Bowdridge,Burgundy A Walters,Sami Agus,Max J Griesgraber,Eliana G Aerts,Michael N Lehman,Lique M Coolen
The current model for the synchronization of GnRH neural activity driving GnRH and LH pulses proposes that a set of arcuate (ARC) neurons that contain kisspeptin, neurokinin B, and dynorphin (KNDy neurons) is the GnRH pulse generator. This study tested the functional role of ovine KNDy neurons in pulse generation and explored the roles of nearby Kiss1 receptor (Kiss1R)-containing cells using lesions
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Puberty Suppression Followed by Testosterone Therapy Does Not Impair Reproductive Potential in Female Mice. Endocrinology (IF 4.8) Pub Date : 2023-09-23 Prachi Godiwala,Tracy F Uliasz,Katie M Lowther,Deborah Kaback,Lisa M Mehlmann
More adolescents are coming out as transgender each year and are put on puberty blockers to suppress natal puberty, which is then followed by cross-hormone treatment to achieve puberty of the desired gender. Studies to examine the effects of puberty suppression and virilizing therapy on future reproductive potential among transgender males are lacking. This study used a translational murine in vitro
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Functional Water Channels Within the TSH Receptor: A New Paradigm for TSH Action With Disease Implications. Endocrinology (IF 4.8) Pub Date : 2023-09-23 Rauf Latif,Terry F Davies,Mihaly Mezei
The thyroid-stimulating hormone receptor (TSHR) transmembrane domain (TMD) is found in the plasma membrane and consists of lipids and water molecules. To understand the role of TSHR-associated water molecules, we used molecular dynamic simulations of the TMD and identified a network of putative receptor-associated transmembrane water channels. This result was confirmed with extended simulations of
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Does Vitamin D 1α Hydroxylase Activity in Osteoblasts Contribute Meaningfully to Abaloparatide's Therapeutic Action? Endocrinology (IF 4.8) Pub Date : 2023-09-23 Robert D Blank
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Neuronal AR Regulates Glucose Homeostasis and Energy Expenditure in Lean Female Mice With Androgen Excess. Endocrinology (IF 4.8) Pub Date : 2023-09-23 Vaibhave Ubba,Serene Joseph,Olubusayo Awe,Dustin Jones,Milan K Dsilva,Mingxiao Feng,Junjiang Wang,Xiaomin Fu,Razeen J Akbar,Brittany H Bodnar,Wenhui Hu,Hong Wang,Xiaofeng Yang,Ling Yang,Peixin Yang,Rexford Ahima,Sara Divall,Sheng Wu
Hyperandrogenemia and polycystic ovary syndrome are a result of the imbalance of androgen levels in females. Androgen receptor (Ar) mediates the effect of androgen, and this study examines how neuronal Ar in the central nervous system mediates metabolism under normal and increased androgen conditions in female mice. The neuron-specific ARKO mouse (SynARKO) was created from female (Ar fl/wt; synapsin
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Adipocyte Glucocorticoid Receptor Inhibits Immune Regulatory Genes to Maintain Immune Cell Homeostasis in Adipose Tissue. Endocrinology (IF 4.8) Pub Date : 2023-09-23 Shripa Amatya,Dylan Tietje-Mckinney,Schaefer Mueller,Maria G Petrillo,Matthew D Woolard,Sushma Bharrhan,Anthony Wayne Orr,Christopher G Kevil,John A Cidlowski,Diana Cruz-Topete
Glucocorticoids acting via the glucocorticoid receptors (GR) are key regulators of metabolism and the stress response. However, uncontrolled or excessive GR signaling adversely affects adipose tissue, including endocrine, immune, and metabolic functions. Inflammation of the adipose tissue promotes systemic metabolic dysfunction; however, the molecular mechanisms underlying the role of adipocyte GR
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Targeting the NAD+ Salvage Pathway: Synergistic Therapeutic Strategy for ER+ Metastatic Breast Cancer. Endocrinology (IF 4.8) Pub Date : 2023-09-23 Rebecca B Riggins,Suman Ranjit
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Research Progress of Metformin in the Treatment of Oral Squamous Cell Carcinoma. Endocrinology (IF 4.8) Pub Date : 2023-09-23 Jiayi Liu,Jing Zhao,Xue Qiao
Oral squamous cell carcinoma (OSCC) is one of the most common malignancies and has a high mortality, posing a great threat to both human physical and mental health. With the advancement of scientific research, a variety of cancer therapies have been used for OSCC treatment. However, the prognosis of OSCC shows no significant improvement. Metformin has been recognized as the first-line drug for the
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Influence of Vitamin D Deficiency on Cyclin D1-Induced Parathyroid Tumorigenesis. Endocrinology (IF 4.8) Pub Date : 2023-09-23 Jessica Costa-Guda,Kristin Corrado,Justin Bellizzi,Elizabeth Saria,Kirsten Saucier,Miriam Guemes-Aragon,Guntas Kakar,Madison Rose,Melanie Pascal,Cynthia Alander,Sanjay M Mallya,Andrew Arnold
Primary hyperparathyroidism (PHPT) is a common endocrinopathy for which several pathogenic mechanisms, including cyclin D1 overexpression, have been identified. Vitamin D nutritional status may influence parathyroid tumorigenesis, but evidence remains circumstantial. To assess the potential influence of vitamin D insufficiency/deficiency on initiation or progression of parathyroid tumorigenesis, we
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Progress Toward and Challenges Remaining for Thyroid Tissue Regeneration. Endocrinology (IF 4.8) Pub Date : 2023-08-28 Mírian Romitti,Sabine Costagliola
Thyroid hormones play a pivotal role in diverse physiological processes, and insufficient synthesis of these hormones results in hypothyroidism, a prevalent disorder with a significant global impact. Research has shown that the residual thyroid tissue following surgery fails to fully regenerate the gland and restore normal function. The slow turnover rate of the thyroid gland and the presence of resident
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Early Combination Therapies for the Preservation of Pancreatic β Cells in Type 2 Diabetes Mellitus. Endocrinology (IF 4.8) Pub Date : 2023-08-28 Nadia Rachdaoui
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Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice. Endocrinology (IF 4.8) Pub Date : 2023-08-28 Lei Zhang,Kumaravel Mohankumar,Gregory Martin,Fuada Mariyam,Yuri Park,Sang Jun Han,Stephen Safe
Nuclear receptor 4A1 (NR4A1) plays an important role in endometriosis progression; levels of NR4A1 in endometriotic lesions are higher than in normal endometrium, and substituted bis-indole analogs (NR4A1) antagonists suppress endometriosis progression in mice with endometriosis. In addition, the flavonoids kaempferol and quercetin are natural products that directly bind NR4A1 and significantly repress
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Skeletal Muscle Function Is Altered in Male Mice on Low-Dose Androgen Receptor Antagonist or Estrogen Receptor Agonist. Endocrinology (IF 4.8) Pub Date : 2023-08-28 Brent A Momb,Gillian K Szabo,Joshua P Mogus,Stuart R Chipkin,Laura N Vandenberg,Mark S Miller
In males, skeletal muscle function may be altered by shifts in either circulating testosterone or estrogen. We examined the effect of acute (2-week) exposures to 17α-ethinyl estradiol (EE2), an estrogen receptor (ER) agonist, or flutamide, an androgen receptor (AR) antagonist, on the contractile function of individual skeletal muscle fibers from slow-contracting soleus and fast-contracting extensor
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Susceptibility to Low Vitamin B6 Diet-induced Gestational Diabetes Is Modulated by Strain Differences in Mice. Endocrinology (IF 4.8) Pub Date : 2023-08-28 Philip Spinelli,Ashley M Fields,Sierra Falcone,Clementina Mesaros,Martha Susiarjo
Gestational diabetes is a common pregnancy complication that adversely influences the health and survival of mother and child. Pancreatic islet serotonin signaling plays an important role in β-cell proliferation in pregnancy, and environmental and genetic factors that disrupt serotonin signaling are associated with gestational diabetes in mice. Our previous studies show that pregnant C57BL/6J mice
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Characterization of Somatotrope Cell Expansion in Response to GHRH in the Neonatal Mouse Pituitary. Endocrinology (IF 4.8) Pub Date : 2023-08-28 Richard L Gonigam,Karen E Weis,Xiyu Ge,Boyuan Yao,Qilin Zhang,Lori T Raetzman
In humans and mice, loss-of-function mutations in growth hormone-releasing hormone receptor (GHRHR) cause isolated GH deficiency. The mutant GHRHR mouse model, GhrhrLit/Lit (LIT), exhibits loss of serum GH, but also fewer somatotropes. However, how loss of GHRH signaling affects expansion of stem and progenitor cells giving rise to GH-producing cells is unknown. LIT mice and wild-type littermates were
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Effect of Fetal Pituitary-Testes Suppression on Brain Sexual Differentiation and Reproductive Function in Male Sheep. Endocrinology (IF 4.8) Pub Date : 2023-08-28 Rebecka Amodei,Sonnet S Jonker,Mary Smallman,William Whitler,Charles T Estill,Charles E Roselli
We previously demonstrated that treating fetal lambs on gestational day 62 with the long-acting gonadotrophin-releasing hormone (GnRH) antagonist degarelix (DG) suppresses pituitary-testicular function during midgestation. The objective of this study was to investigate whether impaired gonadotrophic drive during this fetal period has enduring effects on sexual differentiation and reproductive function
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Acute Deletion of the Glucocorticoid Receptor in Hepatocytes Disrupts Postprandial Lipid Metabolism in Male Mice. Endocrinology (IF 4.8) Pub Date : 2023-08-28 Catarina Mendes Correia,Stine Marie Præstholm,Jesper Foged Havelund,Felix Boel Pedersen,Majken Storm Siersbæk,Morten Frendø Ebbesen,Zach Gerhart-Hines,Joerg Heeren,Jonathan Brewer,Steen Larsen,Blagoy Blagoev,Nils Joakim Færgeman,Lars Grøntved
Hepatic lipid metabolism is highly dynamic, and disruption of several circadian transcriptional regulators results in hepatic steatosis. This includes genetic disruption of the glucocorticoid receptor (GR) as the liver develops. To address the functional role of GR in the adult liver, we used an acute hepatocyte-specific GR knockout model to study temporal hepatic lipid metabolism governed by GR at
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The Mineralocorticoid Receptor Plays a Crucial Role in Macrophage Development and Function. Endocrinology (IF 4.8) Pub Date : 2023-08-28 Erin Faught,Marcel J M Schaaf
Stress and the attendant rise in glucocorticoids (GCs) results in a potent suppression of the immune system. To date, the anti-inflammatory role of GCs, via activation of the glucocorticoid receptor, has been well-characterized. However, cortisol, the primary GC in both fish and humans, also signals through the high-affinity mineralocorticoid receptor (MR), of which the immunomodulatory role is poorly
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Allostasis in Neuroendocrine Systems Controlling Reproduction. Endocrinology (IF 4.8) Pub Date : 2023-08-28 Rodrigo A Carrasco,Kellie M Breen
Allostasis provides a supporting role to the homeostatic control of biological variables in mammalian species. While the concept of homeostasis is related to the control of variables within a set point or range that are essential to life, allostasis refers to systems that facilitate adaptation to challenges that the organism faces and the new requirements for survival. Essential for such adaptation
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Endothelial Biology of Estrogen and Cardiovascular Disease. Endocrinology (IF 4.8) Pub Date : 2023-08-28 Ken Chambliss,Chieko Mineo,Philip W Shaul
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Luteal Lipid Droplets: A Novel Platform for Steroid Synthesis. Endocrinology (IF 4.8) Pub Date : 2023-08-01 Michele R Plewes,Heather A Talbott,Anthony J Saviola,Nicholas T Woods,Micah B Schott,John S Davis
Progesterone is an essential steroid hormone that is required to initiate and maintain pregnancy in mammals and serves as a metabolic intermediate in the synthesis of endogenously produced steroids, including sex hormones and corticosteroids. Steroidogenic luteal cells of the corpus luteum have the tremendous capacity to synthesize progesterone. These specialized cells are highly enriched with lipid
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Mouse Testicular Mkrn3 Expression Is Primarily Interstitial, Increases Peripubertally, and Is Responsive to LH/hCG. Endocrinology (IF 4.8) Pub Date : 2023-08-01 Sidney A Pereira,Fernanda C B Oliveira,Lydie Naulé,Carine Royer,Francisco A R Neves,Ana Paula Abreu,Rona S Carroll,Ursula B Kaiser,Michella S Coelho,Adriana Lofrano-Porto
Studies in humans and mice support a role for Makorin RING finger protein 3 (MKRN3) as an inhibitor of gonadotropin-releasing hormone (GnRH) secretion prepubertally, and its loss of function is the most common genetic cause of central precocious puberty in humans. Studies have shown that the gonads can synthesize neuropeptides and express MKRN3/Mkrn3 mRNA. Therefore, we aimed to investigate the spatiotemporal
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Biosynthesis and Function of VIP and Oxytocin: Mechanisms of C-terminal Amidation, Oxytocin Secretion and Transport. Endocrinology (IF 4.8) Pub Date : 2023-08-01 Hideto Yonekura,Ichiro Kato,Yasuhiko Yamamoto,Takayuki Ikeda,Haruhiro Higashida,Hiroshi Okamoto
In this review, we provide the status of research on vasoactive intestinal peptide (VIP) and oxytocin, typical C-terminal α-amidated peptide hormones, including their precursor protein structures, processing and C-terminal α-amidation, and the recently identified mechanisms of regulation of oxytocin secretion and its transportation through the blood brain barrier. More than half of neural and endocrine
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ERK5 Cooperates With MEF2C to Regulate Nr4a1 Transcription in MA-10 and MLTC-1 Leydig Cells. Endocrinology (IF 4.8) Pub Date : 2023-08-01 Karine de Mattos,Félix-Olivier Dumas,Gabriel Henrique Campolina-Silva,Clémence Belleannée,Robert S Viger,Jacques J Tremblay
Leydig cells produce hormones required for the development and maintenance of sex characteristics and fertility in males. MEF2 transcription factors are important regulators of Leydig cell gene expression and steroidogenesis. ERK5 is an atypical member of the MAP kinase family that modulates transcription factor activity, either by direct phosphorylation or by acting as a transcriptional coactivator
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The Organophosphate Esters Used as Flame Retardants and Plasticizers Affect H295R Adrenal Cell Phenotypes and Functions. Endocrinology (IF 4.8) Pub Date : 2023-08-01 Zixuan Li,Bernard Robaire,Barbara F Hales
Adverse effects associated with exposure to brominated flame retardants have led to regulations for their use and their replacement with organophosphate esters (OPEs). However, little is known about the impact of OPEs on the adrenal, a vital endocrine gland. Here, we used a high-content screening approach to elucidate the effects of OPEs on H295R human adrenal cell phenotypic endpoints and function
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Mechanistic Insights of Thyroid Cancer Progression. Endocrinology (IF 4.8) Pub Date : 2023-08-01 Luis Javier Leandro-García,Iñigo Landa
Differentiated thyroid cancers (DTCs) are primarily initiated by mutations that activate the MAPK signaling cascade, typically at BRAF or RAS oncoproteins. DTCs can evolve to more aggressive forms, specifically, poorly differentiated (PDTC) and anaplastic thyroid cancers (ATC), by acquiring additional genetic alterations which deregulate key pathways. In this review, we focused on bona fide mutations
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Abaloparatide Maintains Normal Rat Blood Calcium Level in Part Via 1,25-Dihydroxyvitamin D/osteocalcin Signaling Pathway. Endocrinology (IF 4.8) Pub Date : 2023-08-01 Yanmei Yang,Wei-Ju Tseng,Bin Wang
The PTH-related peptide(1-34) analog, abaloparatide (ABL), is the second anabolic drug available for the treatment of osteoporosis. Previous research demonstrated that ABL had a potent anabolic effect but caused hypercalcemia at a significantly lower rate. However, the mechanism by which ABL maintains the stability of blood calcium levels remains poorly understood. Our in vivo data showed that ABL
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Opportunities and Challenges in microRNA Research and Clinical Application. Endocrinology (IF 4.8) Pub Date : 2023-08-01 Carolyn M Klinge