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The relationship between weight-adjusted-waist index and diabetic kidney disease in patients with type 2 diabetes mellitus Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-15 Zhaoxiang Wang, Xuejing Shao, Wei Xu, Bingshuang Xue, Shao Zhong, Qichao Yang
PurposeObesity, particularly abdominal obesity, is seen as a risk factor for diabetic complications. The weight-adjusted-waist index (WWI) is a recently developed index for measuring adiposity. Our goal was to uncover the potential correlation between the WWI index and diabetic kidney disease (DKD) risk.MethodsThis cross-sectional study included adults with type 2 diabetes mellitus (T2DM) who participated
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GLP-1RA may have varying effects on cardiac structure in patients with ASCVD depending on BMI Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-15 Ling Xu, Dan Zhu
BackgroundGlucagon-like peptide-1 receptor agonist(GLP-1RA) is commonly used in patients with cardiovascular disease due to its significant improvement in the prognosis of atherosclerotic cardiovascular disease (ASCVD). However, previous studies have primarily focused on obese patients, leaving uncertainty regarding whether GLP-1RA can yield similar cardiovascular benefits in individuals with normal
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Impact of bariatric surgery on ovarian reserve markers and its correlation with nutritional parameters and adipokines Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-15 Alba Andreu, Lilliam Flores, Marta Méndez, Ainize Ibarzabal, Gregori Casals, Imma Mercadé, Aina Borrás, Yasmina Barral, Inés Agustí, Dolors Manau, Josep Vidal, Gemma Casals
IntroductionA reduction in anti-müllerian hormone (AMH) levels at short-term after bariatric surgery (BS) has been previously described. However, an assessment of ovarian reserve at longer-follow up, and a comprehensive evaluation of the potentially implicated factors has not been reported.DesignProspective cohort study.Materials and methodsTwenty women aged 18-40 years with BMI 43.95 kg/m2 undergoing
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Assessment of the severity of diabetic polyneuropathy aids in predicting the risk of developing diabetic complications in patients with untreated diabetes Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-15 Shuji Horinouchi, Takahisa Deguchi, Miki Mukai, Ayako Ijuin, Yudai Kawamoto, Yoshihiko Nishio
This study aimed to determine the efficacy of assessing the severity of diabetic polyneuropathy (DPN) in patients with untreated diabetes. Seventy-two patients with untreated type 2 diabetes who were hospitalized for glycemic control were enrolled and divided into the following two groups: patients who had no prior diagnosis and patients who were unattended or had discontinued treatment. Electrophysiological
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High-fat diets promote peritoneal inflammation and augment endometriosis-associated abdominal hyperalgesia Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-15 Tristin Herup-Wheeler, Mingxin Shi, Madeleine E. Harvey, Chandni Talwar, Ramakrishna Kommagani, James A. MacLean, Kanako Hayashi
Immune dysfunction is one of the central components in the development and progression of endometriosis by establishing a chronic inflammatory environment. Western-style high-fat diets (HFD) have been linked to greater systemic inflammation to cause metabolic and chronic inflammatory diseases, and are also considered an environmental risk factor for gynecologic diseases. Here, we aimed to examine how
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Association between cognitive function and skeletal muscle in patients undergoing maintenance hemodialysis Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-15 Lulu Wang, Xueqin Bian, Lilin Liu, Qingyun He, Jie Xu, Xue Chen, Hong Ye, Junwei Yang, Lei Jiang
BackgroundPatients on hemodialysis have a higher burden of cognitive impairment than individuals of the same age in the general population. Studies have found a link between cognition and skeletal muscle function. However, few studies have investigated these associations and the underlying mechanisms in patients on hemodialysis.MethodsA total of 166 patients on hemodialysis were enrolled in this longitudinal
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U-shaped relationship between fasting blood glucose and urinary albumin-to-creatinine ratio in the general United States population Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-15 Jianling Song, Ping Wang, Hong Li
ObjectiveThe current controversy surrounding the association between fasting blood glucose (FBG) and albuminuria necessitates further investigation. Hence, the primary objective of this study was to examine the relationship between FBG and urinary albumin-to-creatinine ratio (UACR).MethodsA cohort of complete data from National Health and Nutrition Examination Survey (NHANES) participants (1999-2020)
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Mulberry and Hippophae-based solid beverage promotes weight loss in rats by antagonizing white adipose tissue PPARγ and FGFR1 signaling Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-15 Xiao-Ting Zhou, An-Qi Zhu, Xiao-Min Li, Ling-Yue Sun, Jian-Gang Yan, Nin Luo, Shi-Sheng Chen, Zebo Huang, Xin-Liang Mao, Kun-Ping Li
Obesity, a multifactorial disease with many complications, has become a global epidemic. Weight management, including dietary supplementation, has been confirmed to provide relevant health benefits. However, experimental evidence and mechanistic elucidation of dietary supplements in this regard are limited. Here, the weight loss efficacy of MHP, a commercial solid beverage consisting of mulberry leaf
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Blood glucose monitoring devices for type 1 diabetes: a journey from the food and drug administration approval to market availability Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-15 Rahul Mittal, Nicole Koutras, Jonathan Maya, Joana R. N. Lemos, Khemraj Hirani
Blood glucose monitoring constitutes a pivotal element in the clinical management of Type 1 diabetes (T1D), a globally escalating metabolic disorder. Continuous glucose monitoring (CGM) devices have demonstrated efficacy in optimizing glycemic control, mitigating adverse health outcomes, and augmenting the overall quality of life for individuals afflicted with T1D. Recent progress in the field encompasses
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Integrating machine learning and nontargeted plasma lipidomics to explore lipid characteristics of premetabolic syndrome and metabolic syndrome Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-15 Xinfeng Huang, Qing He, Haiping Hu, Huanhuan Shi, Xiaoyang Zhang, Youqiong Xu
ObjectiveTo identify plasma lipid characteristics associated with premetabolic syndrome (pre-MetS) and metabolic syndrome (MetS) and provide biomarkers through machine learning methods.MethodsPlasma lipidomics profiling was conducted using samples from healthy individuals, pre-MetS patients, and MetS patients. Orthogonal partial least squares-discriminant analysis (OPLS-DA) models were employed to
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Endocrine and non-endocrine causes of fatigue in adults with Neurofibromatosis type 1 Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-15 Anna G. W. Rosenberg, Ké Mochèl, Lorena M. Hähner, Lara Ruules, Kirsten Davidse, Anja G. Bos-Roubos, Sarah A. van Dijk, M. Carola Zillikens, Walter Taal, Aart J. van der Lely, Laura C. G. de Graaff
ContextNeurofibromatosis type 1 (NF1) is a complex system disorder, caused by alterations in RAS pathways. NF1 adults often suffer from chronic and severe fatigue, for which they are frequently referred to Internal Medicine/Endocrinology. Seeking medical help often leads to (invasive) diagnostic procedures. To prevent the personal and financial burden of this disabling fatigue, it is crucial to know
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Chemotherapy combined with endocrine neoadjuvant therapy for hormone receptor-positive local advanced breast cancer: a case report and literature review Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-14 Nengying Zhang, Chengmin Luo, Jiayang Li, Yuxiang Bao, Zhongliang Yan, Xiaoming Cheng, Taolang Li, Junyuan Lv
BackgroundEarly studies have revealed antagonistic effects associated with stacking chemotherapy (CT) and endocrine therapy (ET), thereby conventional wisdom does not advocate the simultaneous combination of these two treatment modalities. Limited clinical studies exist on the combined use of neoadjuvant CT (NACT) and neoadjuvant ET (NET), and there are no reported instances of concurrent neoadjuvant
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A Siamese ResNeXt network for predicting carotid intimal thickness of patients with T2DM from fundus images Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-14 AJuan Gong, Wanjin Fu, Heng Li, Na Guo, Tianrong Pan
ObjectiveTo develop and validate an artificial intelligence diagnostic model based on fundus images for predicting Carotid Intima-Media Thickness (CIMT) in individuals with Type 2 Diabetes Mellitus (T2DM).MethodsIn total, 1236 patients with T2DM who had both retinal fundus images and CIMT ultrasound records within a single hospital stay were enrolled. Data were divided into normal and thickened groups
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Rs4862705 in the melatonin receptor 1A gene is associated with renal function decline in type 1 diabetes individuals Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-14 Gustavo Daher, Daniele Pereira Santos-Bezerra, Ana Mercedes Cavaleiro, Tatiana Souza Pelaes, Sharon Nina Admoni, Ricardo Vessoni Perez, Cleide Guimarães Machado, Fernanda Gaspar do Amaral, José Cipolla-Neto, Maria Lúcia Correa-Giannella
AimThe pathogenesis of chronic diabetes complications has oxidative stress as one of the major elements, and single-nucleotide polymorphisms (SNPs) in genes belonging to antioxidant pathways modulate susceptibility to these complications. Considering that melatonin is a powerful antioxidant compound, our aim was to explore, in a longitudinal cohort study of type 1 diabetes (T1D) individuals, the association
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Current barriers to initiating insulin therapy in individuals with type 2 diabetes Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-14 Alba Galdón Sanz-Pastor, Alicia Justel Enríquez, Ana Sánchez Bao, Francisco Javier Ampudia-Blasco
Insulin is an essential drug in the treatment of diabetes, often necessary for managing hyperglycemia in type 2 diabetes mellitus (T2DM). It should be considered in cases of severe hyperglycemia requiring hospitalization, after the failure of other treatments, in advanced chronic kidney disease, liver cirrhosis, post-transplant diabetes, or during pregnancy. Moreover, in specific patient subgroups
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Time for micro-RNAs in steatotic liver disease: a case–control study Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-14 Victor Constantin Stoica, Dimitri Apostol, Mihai Mircea Diculescu, Iuliana Petronela Gârdan, Daniel Adrian Gârdan, Ion Mărunțelu, Ileana Constantinescu
One of the challenges of modern-day living is to resist the temptation of overfeeding and sedentariness and maintain a healthy body and mind. On a favorable genetic and epigenetic background, a high-fat diet combined with lack of physical exercise constitutes the foundation for severe metabolic disturbances including steatotic liver disease. In our case–control study, we had the aim of establishing
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Development and validation of nomograms to predict clinical outcomes of preeclampsia Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-14 Yan Xia, Yao Wang, Shijin Yuan, Jiaming Hu, Lu Zhang, Jiamin Xie, Yang Zhao, Jiahui Hao, Yanwei Ren, Shengjun Wu
BackgroundPreeclampsia (PE) is one of the most severe pregnancy-related diseases; however, there is still a lack of reliable biomarkers. In this study, we aimed to develop models for predicting early-onset PE, severe PE, and the gestation duration of patients with PE.MethodsEligible patients with PE were enrolled and divided into a training (n = 253) and a validation (n = 108) cohort. Multivariate
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The emerging role and clinical significance of circRNAs in papillary thyroid cancer Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-13 Jing Ma, Jing Xu, Xiaoqi Zhang, Jinxing Quan
Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy, and its global incidence has been gradually increasing. For advanced PTC, the mortality rates are also increasing yearly. Despite advancements in diagnosis and treatment, some advanced PTC exhibit aggressive behaviors, leading to a poor prognosis. CircRNAs are a class of non-coding RNAs characterized by a covalently closed
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Motilin fluctuations in healthy volunteers determined by liquid chromatography mass spectrometry Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-13 Rachel E. Foreman, Christopher A. Bannon, Richard G. Kay, Frank Reimann, Fiona M. Gribble
IntroductionMotilin is a hormone secreted by specialised enteroendocrine cells in the small intestine, and is known to modulate gastrointestinal motility in humans, regulating the migratory motor complex. It is understudied at least in part due to the lack of commercially available immunoassays.MethodA multiplexed liquid chromatography mass spectrometry (LC-MS/MS) method was optimised to measure motilin
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Predictive value of ultrasonic artificial intelligence in placental characteristics of early pregnancy for gestational diabetes mellitus Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-13 Huien Zhou, Wanming Chen, Chen Chen, Yanying Zeng, Jialin Chen, Jianru Lin, Kun He, Xinmin Guo
BackgroundTo explore the predictive value of placental features in early pregnancy for gestational diabetes mellitus (GDM) using deep and radiomics-based machine learning (ML) applied to ultrasound imaging (USI), and to develop a nomogram in conjunction with clinical features.MethodsThis retrospective multicenter study included 415 pregnant women at 11-13 weeks of gestation from two institutions: the
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Fertility and sexual activity in patients with Triple A syndrome Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-13 Katja K. Dumic, Claudine Heinrichs, Katrin Koehler, Angela Huebner, Miroslav Dumic, Vesna Kusec, Tina Dusek, Friederike Quitter
ObjectiveTriple A syndrome, caused by autosomal recessively inherited mutations in the AAAS gene is characterized by alacrima, achalasia, adrenal insufficiency, and neurological impairment. To the best of our knowledge, no patients of both sexes have been reported to have offspring. Our aim was to assess the causes of infertility in male patients with this multisystemic syndrome, and to present a female
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Age differences in the association of body mass index-defined obesity with abdominal aortic calcification Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-13 Tangmeng Guo, Lili Huang, Zhijian Luo, Huabo Zheng, Shengshuai Shan, Bei Cheng
ObjectivesIn cardiovascular disease, previous studies have suggested young age as one of the reasons to explain the obesity paradox. This study attempts to provide a different opinion on this claim through unexpected findings.MethodsWe used a cross-sectional analysis of the US nationally representative data, total of 10,175 participants were recruited in 2013-2014 from NHANES. A total of 947 participants
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Comparative study between poorly differentiated thyroid cancer and anaplastic thyroid cancer: real-world pathological distribution, death attribution, and prognostic factor estimation Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-13 Kun Zhang, Xinyi Wang, Tao Wei, Zhihui Li, Jingqiang Zhu, Ya-Wen Chen
BackgroundThe clinic-pathological boundary between poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) is unclear due to a wide spectrum of histopathological features and the rarity of the disease. In addition to that, with the highest mortality rate and non-standard treatment modality, the PDTC/ATC population has not been subjected to comprehensive description and comparison
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Case report: A novel splice-site mutation of MTX2 gene caused mandibuloacral dysplasia progeroid syndrome: the first report from China and literature review Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-13 Xiaohui Fu, Shuli Chen, Xiao Huang, Qinghua Lu, Yunfei Cui, Weinan Lin, Qin Yang
BackgroundMandibuloacral dysplasia (MAD) syndrome is a rare genetic disease. Several progeroid syndromes including mandibuloacral dysplasia type A (MADA), mandibuloacral dysplasia type B(MADB), Hutchinson-Gilford progeria (HGPS) and mandibular hypoplasia, deafness, and lipodystrophy syndrome (MDPL) have been reported previously. A novel MAD progeroid syndrome (MADaM) has recently been reported. So
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Interleukin-16 is increased in obesity and alters adipogenesis and inflammation in vitro Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-13 Marjorie Reyes-Farias, Pablo Fernández-García, Patricia Corrales, Lorena González, Andrea Soria-Gondek, Ester Martínez, Silvia Pellitero, Jordi Tarascó, Pau Moreno, Lauro Sumoy, Gema Medina-Gómez, David Sánchez-Infantes, Laura Herrero
IntroductionObesity is a chronic condition associated with low-grade inflammation mainly due to immune cell infiltration of white adipose tissue (WAT). WAT is distributed into two main depots: subcutaneous WAT (sWAT) and visceral WAT (vWAT), each with different biochemical features and metabolic roles. Proinflammatory cytokines including interleukin (IL)-16 are secreted by both adipocytes and infiltrated
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Phenotype of early-onset fetal growth restriction in sheep Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-13 Amy E. Sutherland, Tegan A. White, Charmaine R. Rock, Beth R. Piscopo, Ingrid Dudink, Ishmael M. Inocencio, Zahrah Azman, Yen Pham, Ilias Nitsos, Atul Malhotra, Tamara Yawno, Graeme R. Polglase, Graham Jenkin, Emily J. Camm, Beth J. Allison, Suzanne L. Miller
IntroductionFetal growth restriction (FGR) is a common pregnancy complication, caused by placental insufficiency, with serious adverse consequences for development in utero and postnatal wellbeing. There are no antenatal treatments to improve growth or organ development in FGR, and animal models are essential to mimic the physiological adaptations in FGR and to assess potential interventions. This
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Causal relationship between Alzheimer’s disease and prostate cancer: a bidirectional Mendelian randomization analysis Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-13 Rongkang Li, Lei Peng, Dashi Deng, Guangzhi Li, Song Wu
BackgroundPrevious observational researchers have found an inverse bidirectional link between Alzheimer’s disease (AD) and prostate cancer (PCa); yet, the causative nature of this link remains unclear. To investigate the causal interactions between AD and PCa, a bidirectional Mendelian randomization (MR) analysis was conducted.MethodsThis study comprised two Genome-Wide Association Study (GWAS) summary
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Cushing’s syndrome during pregnancy - two case reports Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-12 Sumita Cholekho, Yuke Liu, Huiwen Tan
BackgroundCushing’s syndrome (CS) during pregnancy is a rare endocrine disorder characterized by hypercortisolism, which is significantly associated with maternal-fetal complications. Despite its rarity, CS during pregnancy may be related to a high risk of complications for both the mother and fetus.The aim of the present case study is to update the diagnostic approach to CS during pregnancy and the
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Developmental potential of non- and mono-pronuclear zygotes and associated clinical outcomes in IVF cycles Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-12 Mengyi Zhu, Qiyin Dong, Yurong Zhu, Yun Le, Tengfei Wang, Yuanping Zhou, Sheng Yang
PurposeThis study aims to evaluate the developmental potential of 0PN, 1PN, and 2PN zygotes in IVF cycles and compare their clinical outcomes.MethodsWe conducted a retrospective cohort study involving IVF patients. Blastocyst formation rates were assessed with 0PN, 1PN, and 2PN zygotes. Subsequently, we collected clinical outcome data following the transfer of these zygotes.ResultsThe overall blastulation
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Investigating the impact of elevated urinary trace elements on non-alcoholic fatty liver disease using vibration-controlled transient elastography Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-12 Chenxiao Wang, Xin Shang, Yu Fu, Panpan Guo, Ping Wang, Shuxun Yan
IntroductionNon-alcoholic fatty liver disease (NAFLD) is a global public health concern. However, limited data are available on urinary trace elements and NAFLD caused by various exposure factors. This study aimed to investigate the relationship between the presence of 16 trace elements in urine and NAFLD using data from the National Health and Nutrition Examination Survey (NHANES).MethodsBy utilizing
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Roles of organokines in intervertebral disc homeostasis and degeneration Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-12 Yuxin He, Sheng Liu, Hui Lin, Fan Ding, Zengwu Shao, Liming Xiong
The intervertebral disc is not isolated from other tissues. Recently, abundant research has linked intervertebral disc homeostasis and degeneration to various systemic diseases, including obesity, metabolic syndrome, and diabetes. Organokines are a group of diverse factors named for the tissue of origin, including adipokines, osteokines, myokines, cardiokines, gastrointestinal hormones, and hepatokines
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Cryptorchidism and puberty Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-12 Wiwat Rodprasert, Helena E. Virtanen, Jorma Toppari
Cryptorchidism is the condition in which one or both testes have not descended adequately into the scrotum. The congenital form of cryptorchidism is one of the most prevalent urogenital anomalies in male newborns. In the acquired form of cryptorchidism, the testis that was previously descended normally is no longer located in the scrotum. Cryptorchidism is associated with an increased risk of infertility
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Correlation between seminal plasma biochemical markers and semen parameters in idiopathic oligoasthenoteratospermia: identification of biomarkers for L-carnitine therapy Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-12 Qilong Yuan, Ruifang Hong, Yunping Ni, Manbo Jiang, Juan Liu, Zhiqiang Chen, Dongyu Yang
BackgroundL-carnitine therapy for idiopathic sperm abnormalities exhibits variable effectiveness, and currently, there are no established criteria to predict patient response. This study investigated correlations between seminal plasma markers and semen parameters to identify biomarkers that can guide indications for L-carnitine therapy indications in patients with idiopathic sperm abnormalities.MethodsA
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Characterization of sensory and motor dysfunction and morphological alterations in late stages of type 2 diabetic mice Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-11 Ting Tian, Haofeng Li, Sensen Zhang, Maojun Yang
Diabetic neuropathy is the most common complication of diabetes and lacks effective treatments. Although sensory dysfunction during the early stages of diabetes has been extensively studied in various animal models, the functional and morphological alterations in sensory and motor systems during late stages of diabetes remain largely unexplored. In the current work, we examined the influence of diabetes
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Independent association of general and central adiposity with risk of gallstone disease: observational and genetic analyses Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-11 Min Zhang, Ye Bai, Yutong Wang, Huijie Cui, Wenqiang Zhang, Li Zhang, Peijing Yan, Mingshuang Tang, Yunjie Liu, Xia Jiang, Ben Zhang
BackgroundGeneral obesity is a well-established risk factor for gallstone disease (GSD), but whether central obesity contributes additional independent risk remains controversial. We aimed to comprehensively clarify the effect of body fat distribution on GSD.MethodsWe first investigated the observational association of central adiposity, characterized by waist-to-hip ratio (WHR), with GSD risk using
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Ultrasound-guided fine needle aspiration thyroglobulin in the diagnosis of lymph node metastasis of differentiated papillary thyroid carcinoma and its influencing factors Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-11 Xuejiao Su, Lei Shang, Can Yue, Buyun Ma
BackgroundUltrasound-guided fine needle aspiration thyroglobulin (FNA-Tg) is recommended for the diagnosis of lymph node metastasis (LNM) in differentiated thyroid cancer (DTC), but its optimal cutoff value remains controversial, and the effect of potential influencing factors on FNA-Tg levels is unclear.MethodIn this study, a retrospective analysis was conducted on 281 patients diagnosed with DTC
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Causal relationship between genetically predicted type 2 diabetes mellitus and male infertility Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-11 Cuihua Fan, Jiandong Zhang, Dongbiao Qiu
BackgroundDiabetes mellitus (DM) stands as the most prevalent endocrine abnormality affecting the physiological systems and organs and impairing the male reproductive functions. Type 2 Diabetes Mellitus (T2DM), accounting for about 90-95% of DM, is closely associated with male infertility. However, the magnitude of the causal relationships between T2DM and male infertility remains unclear. The current
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Cost-effective prognostic evaluation of breast cancer: using a STAR nomogram model based on routine blood tests Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-11 Caibiao Wei, Yihua Liang, Dan Mo, Qiumei Lin, Zhimin Liu, Meiqin Li, Yuling Qin, Min Fang
BackgroundBreast cancer (BC) is the most common and prominent deadly disease among women. Predicting BC survival mainly relies on TNM staging, molecular profiling and imaging, hampered by subjectivity and expenses. This study aimed to establish an economical and reliable model using the most common preoperative routine blood tests (RT) data for survival and surveillance strategy management.MethodsWe
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Exploring the potential of pheophorbide A, a chlorophyll-derived compound in modulating GLUT for maintaining glucose homeostasis Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-11 Saptadipa Paul, Anuma Pallavi, Nikhil R. Gandasi
IntroductionPheophorbide A, a chlorophyll-breakdown product, is primarily investigated for its anti-oxidant and anti-inflammatory activity. Recent reports on pheophorbide A have shown its potential in lowering blood glucose levels, thus leading to the exploration of its use in diabetes management. Literature has also shown its effect on enhanced insulin secretion, whereas its mechanism on glucose stimulated
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Total weight loss rather than preoperative body mass index correlates with remission of irregular menstruation after sleeve gastrectomy in patients with polycystic ovary syndrome Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-11 Yian Zhao, Sisi Xiong, Teng Liu, Jiaxin Shu, Tao Zhu, Shumin Li, Mingwei Zhong, Shigang Zhao, Xin Huang, Shaozhuang Liu
IntroductionPolycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting reproductive-aged women. Some retrospective studies with small sample sizes have reported that bariatric metabolic surgery is effective in remission of irregular menstruation in patients with PCOS and obesity. However, the correlation between preoperative body mass index (BMI), postoperative weight loss, and remission
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Sirtuin 1 serum concentration in healthy children - dependence on sex, age, stage of puberty, body weight and diet Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-11 Anna Fedorczak, Andrzej Lewiński, Renata Stawerska
IntroductionSirtuin 1 (SIRT1) is known to be involved in sensing cellular energy levels and regulating energy metabolism. This study aimed to evaluate fasting serum SIRT1 levels in healthy children, and to analyse the influence of age, sex, puberty, body weight, height, and diet on its concentration.Methods47 healthy children aged 4-14 with weight and height within normal range and no chronic disease
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Safety, tolerability, pharmacokinetics and pharmacokinetic-pharmacodynamic modeling of cetagliptin in patients with type 2 diabetes mellitus Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-11 Chen Zhou, Sufeng Zhou, Jie Wang, Lijun Xie, Zhanhui Lv, Yuqing Zhao, Lu Wang, Huan Luo, Daosheng Xie, Feng Shao
AimsTo evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of cetagliptin (CAS number:2243737-33-7) in Chinese patients with type 2 diabetes mellitus (T2DM). A population PK/PD model was developed to quantify the PK and PD characteristics of cetagliptin in patients.Materials and methods32 Chinese adults with T2DM were enrolled in this study. The subjects were randomly
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Overlapping action of T3 and T4 during Xenopus laevis development Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-11 Alicia Tribondeau, David Du Pasquier, Médine Benchouaia, Corinne Blugeon, Nicolas Buisine, Laurent M. Sachs
Thyroid hormones are involved in many biological processes such as neurogenesis, metabolism, and development. However, compounds called endocrine disruptors can alter thyroid hormone signaling and induce unwanted effects on human and ecosystems health. Regulatory tests have been developed to detect these compounds but need to be significantly improved by proposing novel endpoints and key events. The
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A lactate metabolism-related signature predicting patient prognosis and immune microenvironment in ovarian cancer Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-11 Linhua Zhu, Zhuoqun Lin, Kai Wang, Jiaxin Gu, Xiaojing Chen, Ruizhe Chen, Lingfang Wang, Xiaodong Cheng
IntroductionOvarian cancer (OV) is a highly lethal gynecological malignancy with a poor prognosis. Lactate metabolism is crucial for tumor cell survival, proliferation, and immune evasion. Our study aims to investigate the role of lactate metabolism-related genes (LMRGs) in OV and their potential as biomarkers for prognosis, immune microenvironment, and immunotherapy response.MethodsOvarian samples
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The thrombotic risk in Cushing’s syndrome—questions, answers, and the algorithm to consider in its assessment: part I—thrombotic risk not related to surgery Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-11 Agata Hanna Bryk-Wiązania, Mari Minasyan, Renata Świątkowska-Stodulska, Anetta Undas, Alicja Hubalewska-Dydejczyk, Susan M. Webb, Elena Valassi, Aleksandra Gilis-Januszewska
IntroductionRecently, it has been reported that there is a great diversity in strategies used for thromboprophylaxis in patients with Cushing’s syndrome (CS). An aim of this review was to discuss these practices in light of the existing data on the thrombotic risk in patients with CS and guidelines for medically ill patients.MethodsThe four relevant topics and questions on thrombotic risk in CS were
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Beverage consumption and obesity in Kuwaiti school children Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-11 Muhanad Alhareky, Jo Max Goodson, Mary Tavares, Mor-Li Hartman
Sweetened beverage consumption is particularly important in countries such as Kuwait, where the prevalence of obesity is high, and most children drink sweetened beverages daily. To assess the relationship between three most commonly consumed beverages, (soda, milk, and juice) and the incidence of obesity among Kuwaiti children at the critical age of 10-12 year, Longitudinal cohort data of 6,305 children
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Clinical features of early-onset type 2 diabetes and its association with triglyceride glucose-body mass index: a cross-sectional study Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-11 Yanjuan Jiang, Xiaoyang Lai
ObjectiveThe incidence of early-onset type 2 diabetes (T2D) has increased significantly, with insulin resistance (IR) and obesity being the main drivers of its onset. This study aims to investigate the clinical characteristics of early-onset T2D and its association with triglyceride glucose body mass index (TyG-BMI), an emerging surrogate of IR.MethodsA total of 1000 adults newly diagnosed with T2D
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Prediction of immunotherapy response in idiopathic membranous nephropathy using deep learning-pathological and clinical factors Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-08 Xuejiao Wei, Mengtuan Long, Zhongyu Fan, Yue Hou, Xiaoyu Zhu, Zhihui Qu, Yujun Du
BackgroundOwing to individual heterogeneity, patients with idiopathic membranous nephropathy (IMN) exhibit varying sensitivities to immunotherapy. This study aimed to establish and validate a model incorporating pathological and clinical features using deep learning training to evaluate the response of patients with IMN to immunosuppressive therapy.MethodsThe 291 patients were randomly categorized
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Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-08 Ahmad Mohd Faizal, Marjanu Hikmah Elias, Norazilah Mat Jin, Muhammad Azrai Abu, Saiful Effendi Syafruddin, Ani Amelia Zainuddin, Nao Suzuki, Abdul Kadir Abdul Karim
The leading indicator for successful outcomes in in-vitro fertilization (IVF) is the quality of gametes in oocytes and sperm. Thus, advanced research aims to highlight the parameter in assessing these qualities – DNA fragmentation in sperm and oocyte development capacity (ODC) via evaluation of microenvironments involving its maturation process. Regarding oocytes, most evidence reveals the role of
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Expression and clinical value of CXCR4 in high grade gastroenteropancreatic neuroendocrine neoplasms Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-08 Chaoyu Pang, Yongzheng Li, Ming Shi, Zhiyao Fan, Xin Gao, Yufan Meng, Shujie Liu, Changhao Gao, Peng Su, Xiao Wang, Hanxiang Zhan
BackgroundCXC chemokine receptor 4 (CXCR4) is associated with the progression and metastasis of numerous malignant tumors. However, its relationship with Gastroenteropancreatic Neuroendocrine Neoplasms Grade 3 (GEP-NENs G3) is unclear. The aim of this study was to characterize the expression of CXCR4 in GEP-NENS and to explore the clinical and prognostic value of CXCR4.MethodsThis study retrospectively
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Phthalate metabolites and sex steroid hormones in relation to obesity in US adults: NHANES 2013-2016 Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-08 Jiechang Zhang, Wen Gu, Shilei Zhai, Yumeng Liu, Chengcheng Yang, Lishun Xiao, Ding Chen
BackgroundObesity and metabolic syndrome pose significant health challenges in the United States (US), with connections to disruptions in sex hormone regulation. The increasing prevalence of obesity and metabolic syndrome might be associated with exposure to phthalates (PAEs). Further exploration of the impact of PAEs on obesity is crucial, particularly from a sex hormone perspective.MethodsA total
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Effectiveness and safety of glucagon-like peptide 1 receptor agonists in patients with type 2 diabetes: evidence from a retrospective real-world study Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-08 Yan Jiang, Han-Sheng Bai, Guo-Xin Liu, Shi-Yi Wang, Li Yin, Zhao-Ting Hou, Chen-Yang Zhao, Guang-Jun Fan
IntroductionGlobal phase III clinical trials have shown superior hypoglycemic efficacy to insulin and other oral hypoglycemic agents. However, there is a scarcity of real-world data comparing different glucagon-like peptide 1 receptor agonist (GLP-1RA) directly. This study aimed to assess the safety and effectiveness of various GLP-1RA in treating type 2 diabetes mellitus (T2DM) in a real-world clinical
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Vericiguat in patients with heart failure across the spectrum of left ventricular ejection fraction: a patient-level, pooled meta-analysis of VITALITY-HFpEF and VICTORIA Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-08 Chao Chen, Jin Lv, Changzhao Liu
Vericiguat, the newest soluble guanylate cyclase (sGC) drug, is potentially beneficial in treating heart failure (HF). However, most studies have only confirmed the significant impact of sGC in patients with reduced left ventricular ejection fraction (LVEF). Therefore, the main objective of this meta-analysis was to comparatively analyze the effects of Vericiguat in the entire LVEF range based on previous
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Semaglutide as a potential therapeutic alternative for HNF1B-MODY: a case study Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-08 Angham Almutair, Beshaier Almulhem
Maturity-onset diabetes of the young (MODY) is a grouping of monogenic disorders. It is characterized by dominantly inherited, non-insulin-dependent diabetes. MODY is relatively rare, encompassing up to 3.5% in those diagnosed under 30 years of age. Specific types are most commonly treated with sulfonylurea, particularly those identified as HNF4A-MODY and HNF1A-MODY. HNF1B-MODY is another type that
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Anti-osteoporotic treatments in the era of non-alcoholic fatty liver disease: friend or foe Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-08 Maria Eleni Chondrogianni, Ioannis Kyrou, Theodoros Androutsakos, Christina-Maria Flessa, Evangelos Menenakos, Kamaljit Kaur Chatha, Yekaterina Aranan, Athanasios G. Papavassiliou, Eva Kassi, Harpal S. Randeva
Over the last years non-alcoholic fatty liver disease (NAFLD) has grown into the most common chronic liver disease globally, affecting 17-38% of the general population and 50-75% of patients with obesity and/or type 2 diabetes mellitus (T2DM). NAFLD encompasses a spectrum of chronic liver diseases, ranging from simple steatosis (non-alcoholic fatty liver, NAFL) and non-alcoholic steatohepatitis (NASH;
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Comparison of seven anthropometric indexes to predict hypertension plus hyperuricemia among U.S. adults Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-08 Ye Li, Ling Zeng
PurposeThis study aims to compare the association of hypertension plus hyperuricemia (HTN-HUA) with seven anthropometric indexes. These include the atherogenic index of plasma (AIP), lipid accumulation product (LAP), visceral adiposity index (VAI), triglyceride-glucose index (TyG), body roundness index (BRI), a body shape index (ABSI), and the cardiometabolic index (CMI).MethodsData was procured from
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Association of the metabolic score for insulin resistance with cardiovascular diseases, cardiovascular and all-cause mortality in Chinese hypertensive population Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-08 Liting Zhang, Chao Yu, Tao Wang, Wei Zhou, Huihui Bao, Xiaoshu Cheng
ImportanceLittle is known about the relationship between the metabolic score for insulin resistance (METS-IR) and the prognosis of hypertensive patients in China.ObjectiveTo investigate the association between the novel non–insulin‐based METS-IR index and the cardiovascular composite endpoints and all-cause mortality in Chinese hypertensive participants.Design, setting, and participantsThis cohort
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Quantitative assessment of OCT and OCTA parameters in diabetic retinopathy with and without macular edema: single-center cross-sectional analysis Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-08 Yanyan Cui, Dongfan Feng, Changlong Wu, Ping Wang, Ruoxi Cui, Xiaokun Wang, Weiwei Chang, Weiwei Shang, Bojun Zhao, Jing Liu, Xuejiao Qin
AimThe retinal and choroidal parameters were analyzed to understand the impairment of microcirculation of both retina and choroid in patients with diabetic retinopathy (DR).MethodsFifty-five treatment-naive non-proliferative diabetic retinopathy (NPDR) patients (75 eyes) with type 2 diabetes mellitus (T2DM), including 28 patients (36 eyes) with diabetic macular edema (DME) and 27 patients (39 eyes)
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Treg cells as a protective factor for Hashimoto`s thyroiditis: a Mendelian randomization study Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-07 Jinzhou Guo, Gao Si, Fuchun Si
Background and objectivesHashimoto’s thyroiditis (HT), a chronic autoimmune disorder impacting thyroid function, is a growing public health concern. The relationship between Treg cells and HT has been extensively studied, with Treg cells considered crucial in suppressing HT progression. However, these studies have mainly been observational, limiting our understanding of Treg cells’ impact on HT risk
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Appropriate whole genome amplification and pathogenic loci detection can improve the accuracy of preimplantation genetic diagnosis for deletional α-thalassemia Front. Endocrinol. (IF 5.2) Pub Date : 2024-03-07 Yueyun Lan, Hong Zhou, Sheng He, Jinhui Shu, Lifang Liang, Hongwei Wei, Jingsi Luo, Caizhu Wang, Xin Zhao, Qingming Qiu, Peng Huang
ObjectiveTo improve the accuracy of preimplantation genetic testing (PGT) in deletional α-thalassemia patients.DesignArticle.Patient(s)fifty-two deletional α-thalassemia couples.Intervention(s)Whole genome amplification (WGA), Next-generation sequencing (NGS) and PCR mutation loci detection.Main outcome measuresWGA, Single nucleotide polymorphism (SNP) and PCR mutation loci detection results; Analysis