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Real-World Clinical Experience with SGLT2 Inhibitors: Use of Special Screening Tool for Type 2 Diabetes Patients to Avoid Serious Adverse Events: A Single-Centre Prospective Study Int. J. Diabetes Metab. Pub Date : 2020-09-09 Vishwa B. Unadkat, Sandeep Sharma, Ruchi Omar
Background: Promising results of clinical trials involving SGLT2 inhibitors urge every clinician managing diabetes to use them. However, upcoming real-world data still show increased incidence of adverse events, but efficacy is comparable to clinical trials. Objectives: Genitourinary infection is the most commonly reported adverse effect with SGLT2 inhibitors. We evaluated effectiveness of patient
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Adiponectin and Leptin Adipocytokines in Metabolic Syndrome: What Is Its Importance? Int. J. Diabetes Metab. Pub Date : 2020-09-17 María Luz Gunturiz Albarracín, Ana Yibby Forero Torres
The global obesity epidemic has motivated a large number of investigations related to adipose tissue. Within the advances in this area, a variety of factors secreted by adipose tissue and with regulatory activity on caloric intake, energy expenditure, reproduction, locomotor activity, glycidic and lipid metabolism, immune response, and bone physiology have been described. Among these adipocyte hormones
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Carbohydrate Restriction and Growth Failure in Two Children with Type 1 Diabetes: A Case Report Int. J. Diabetes Metab. Pub Date : 2020-10-06 Roberto Franceschi, Caterina Rizzardi, Vittoria Cauvin, Federica Berchielli, Alice Liguori, Massimo Soffiati
Variety of media have popularized restrictive diets in diabetes mellitus reporting that carbohydrates are the cause of glycemic excursion, excessive insulin dosage, and weight gain. We report 2 cases of children with type 1 diabetes where adherence to restricted carbohydrate diets caused growth failure. Two prepubertal patients with type 1 diabetes presented at follow-up visit during the honeymoon
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Effects of Hyperuricemia on Beta-Cell Function, Renal Function, and Lipid Panels of Patients with Diabetic Kidney Disease: A Gender-Based Retrospective Study Int. J. Diabetes Metab. Pub Date : 2020-10-08 Prateek Rajkarnikar, Yancheng Xu, Arun Bhattarai
Objective: Serum uric acid (SUA) has been linked with development and progression of diabetic kidney disease (DKD). In this study, we intend to compare the effects of hyperuricemia (HUA) on beta-cell function, renal function, and lipid panels of patients with DKD. Methods: A total of 492 patients with DKD were included for data collection and analysis. Males and females have different standard SUA
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Pattern, Trend and Predictors of Adult-Onset Type 1 Diabetes in Uyo, Nigeria Int. J. Diabetes Metab. Pub Date : 2020-10-22 Collins Amadi, Olufisayo G. Ayoade, Samuel I. Onung, Sarah I. Essien, Anietie A. Etuk, Chidozie J. Okafor
Background: Unlike what obtains in childhood-onset type 1 diabetes, there remains a paucity of data on adult-onset type 1 diabetes in Nigeria. Hence, the current study aimed to determine the general characteristics of adult-onset type 1 diabetes among subjects (aged ≥18 years) presenting at the University of Uyo Teaching Hospital (UUTH) in Akwa Ibom State, South-south Nigeria. Methods: A 5-year (2014–2018)
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COVID-19 and Diabetes Mellitus: The Link and Clinical Implications Int. J. Diabetes Metab. Pub Date : 2020-10-23 Chidiebere V. Ugwueze, Basil Chukwuma Ezeokpo, Bede I. Nnolim, Emmanuel A. Agim, Nnamdi C. Anikpo, Kenechukwu E. Onyekachi
Background: Coronavirus disease 2019 (COVID-19) is a pandemic viral infection that has ravaged the world in recent times, and the associated morbidity and mortality have been much more pronounced in those with noncommunicable disease. Diabetes mellitus is one of commonest noncommunicable diseases associated with worsening clinical status in COVID-19 patients. Summary: The aim of this review was to
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Effects of Continuous Subcutaneous Insulin Infusion on Glycaemic Control and Acute Complications in Young People with Type 1 Diabetes in Bangladesh Int. J. Diabetes Metab. Pub Date : 2020-10-28 Bedowra Zabeen, Jebun Nahar, Nasreen Islam, Kishwar Azad, Kim Donaghue
Objective: The objective of this study was to assess the effects of continuous subcutaneous insulin infusion (CSII) therapy on glycaemic control and acute complications in children, adolescents, and young adults with type 1 diabetes mellitus (T1DM). Methods: The prospective observational study was done in patients on multiple daily injection (MDI) switching to pump system. All patients were followed
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Tele-Management of Diabetes in the Post-COVID-19 Era Int. J. Diabetes Metab. Pub Date : 2020-09-02 Muhammad H. Farooqi
Dubai Diabetes Endocrinol J
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Transcription Factor 7-Like-2 (TCF7L2) rs7903146 (C/T) Polymorphism in Patients with Type 2 Diabetes Mellitus Int. J. Diabetes Metab. Pub Date : 2020-09-02 Ahmed Mohamed Bahaaeldin, Arig Aly Seif, Amira Ibrahim Hamed, Walaa Ahmed Yousry Kabiel
Introduction: Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by the incapability of pancreas to increase insulin secretion to compensate for insulin resistance in the peripheral tissues. T2DM is a multifactorial disease including several environmental factors with the presence of genetic predisposition. The transcription factor 7-like-2 gene (TCF7L2) rs7903146 (C/T) polymorphism
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Diabetes Distress and Associated Factors in Patients with Diabetes Mellitus in South East Nigeria Int. J. Diabetes Metab. Pub Date : 2020-08-31 Belonwu M. Onyenekwe, Ekenechukwu E. Young, Chidimma B. Nwatu, Christian I. Okafor, Chidiebere V. Ugwueze
Background: Diabetes distress (DD) is a common worldwide problem in diabetic patients irrespective of age and type of treatment. In the DAWN 2 study (Diabetes Attitudes, Wishes, and Needs), DD was reported by 44.6% of participants. Objectives: The purpose of this study was to assess the prevalence and level of DD and its associated factors among adult diabetic patients in South East Nigeria. Methods:
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Utilizing Telemedicine for Group Visit Provider Encounters: A Feasibility and Acceptability Study. Int. J. Diabetes Metab. Pub Date : 2020-08-02 Tushar A Patel,Craig A Johnston,Victor J Cardenas,Elizabeth M Vaughan
BACKGROUND The value of telemedicine has been underscored during the coronavirus pandemic. Utilizing telemedicine could markedly enhance group visit scalability and sustainability. However, there are limited data demonstrating telemedicine use for group visits. OBJECTIVE To evaluate the feasibility and acceptability of provider encounters conducted via telemedicine in group visits. MATERIALS AND METHODS
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A Comparison of the Changes in Gestational Weight, Body Mass Index, and Serum Vitamin D Level in Gestational Diabetes Mellitus Patients Complemented with Vitamin D in Contrast to Those Who Did Not Receive the Supplement: A Protocol for Systematic Review and Meta-Analysis of Randomised Controlled Trials Int. J. Diabetes Metab. Pub Date : 2019-12-20 Sumanta Saha, Sujata Saha
Aims: To date, it is largely unknown how body mass index (BMI), gestational weight (GW), and stored vitamin D (25(OH)D) levels change in the vitamin D-supplemented gestational diabetes mellitus (GDM) patients, irrespective of their pre-pregnancy BMI. Therefore, to study this association, a prospective systematic review and meta-analysis protocol is proposed here. Methods: Primarily, different databases
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Assessment of the Outcome of Diabetic Foot Ulcers in Basrah, Southern Iraq: A Cohort Study Int. J. Diabetes Metab. Pub Date : 2019-01-01 Abdulhussein Marzoq, Nadeem Shiaa, Raghda Zaboon, Qutaiba Baghlany, Majid H. Alabbood
Background: Diabetic foot ulcers are one of the most severe and costly complications of diabetes. Foot ulcers result from a combination of multiple causes including peripheral neuropathy and peripheral arterial disease. Patients with diabetic foot ulcers frequently require amputation of the lower limb. Objectives: The aim of this study was to assess the outcome of diabetic foot ulcers among Iraqi patients
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Adherence of Patients with Diabetes to a Lifestyle Advice and Management Plan in Basra, Southern Iraq Int. J. Diabetes Metab. Pub Date : 2019-01-01 Rawnaq Adil Aladhab, Majid Hameed Alabbood
Background: Poor adherence to treatment regimens is a complex problem, especially for those with chronic illnesses. Noncompliance is believed to be the most common reason for treatment failure in diabetic patients, leading to the absence of metabolic control and accelerating disease-related complications. Data on the adherence of people with diabetes in Iraq are lacking. Objectives: The purpose of
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Dyslipidaemia in Nigerian Children and Adolescents with Diabetes Mellitus: Prevalence and Associated Risk Factors Int. J. Diabetes Metab. Pub Date : 2019-01-01 Tamunopriye Caleb Jaja, Iroro E. Yarhere
Background: Dyslipidaemia is prevalent in children and adolescents with type 1 diabetes and can worsen the presentation of chronic complications such as nephropathy, retinopathy, and neuropathy. The aim of this study is to determine the frequency of dyslipidaemia in children living with diabetes followed up at a paediatric endocrine clinic in southern Nigeria and to identify associations with demographic
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Prevalence of Gestational Diabetes in South East Nigeria Using the Updated Diagnostic Guidelines Int. J. Diabetes Metab. Pub Date : 2019-01-01 Belonwu M. Onyenekwe, Ekenechukwu E. Young, Chidinma B. Nwatu, Christian I. Okafor, Chidiebere V. Ugwueze, Sunday N. Chukwu
Background: Controversy still surrounds the choice of screening methods for gestational diabetes mellitus (GDM). Updated guidelines on hyperglycemias in pregnancy, recognizes 2 categories; Diabetes in pregnancy or pre-gestational diabetes and GDM. Early screening and diagnosis of GDM prevents maternal and fetal adverse outcomes. Study Objective: The aim of the study was to determine the prevalence
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Developing and Validating the Educational Materials for a Nurse-Led Self-Management Education in Adults with Type 2 Diabetes Int. J. Diabetes Metab. Pub Date : 2019-01-01 Golnaz Azami, Kim Lam Soh, Shariff-Ghazali Sazlina, Md.Said Salmiah, Sanaz Aazami, Moseyed Mozafari, Hamid Taghinejad, Behzad Badakhsh
Background: Diabetes education and self-care are the cornerstones of diabetes management. There are few nurse-led structured diabetes management programs available in Iran. Objectives: This paper aims to develop and validate a nurse-led diabetes self-management intervention for patients with type 2 diabetes. Method: The theoretical framework underpinning the intervention was the Bandura’s self-efficacy
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Magnitude and Determinants of Hypothyroidism among Dyslipidemic Patients in Bangladesh: A Hospital-Based Cross-Sectional Study Int. J. Diabetes Metab. Pub Date : 2019-01-01 Rokshana Rabeya, Sanjana Zaman, Ariful Bari Chowdhury, Mohammad Hayatun Nabi, Mohammad Delwer Hossain Hawlader
Background: Dyslipidemia is one of the most commonly experienced metabolic disorders, and it is strongly related to atherosclerotic cardiovascular disease. Hypothyroidism is a clinical syndrome resulting from a deficiency of thyroid hormones. Several studies from developed countries provide evidence that the rate of hypothyroidism in dyslipidemic patients is higher, but there is a scarcity of data
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Hypoglycemic Agents and Changes in Oxidative Stress Indices, Electrolytes, and Cardiovascular Risk Factors in Type 2 Diabetes Int. J. Diabetes Metab. Pub Date : 2019-01-01 Augusta Chinyere Nsonwu-Anyanwu, Magnus Chinonye Nsonwu, Chinyere Adanna Opara Usoro
Background: Metabolic complications of type 2 diabetes (T2DM), including dyslipidemia, electrolyte imbalance, and oxidative stress, have been shown to be modulated by hypoglycemic agents. Objective: The lipid profile, electrolytes, and oxidative stress indices were evaluated in T2DM. Methods: Fifty T2DM patients on metformin (n = 23), insulin (n = 17), and insulin/metformin (n = 10) and 40 controls
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Insulin Resistance Index and Proatherogenic Lipid Indices in the Offspring of People with Diabetes Int. J. Diabetes Metab. Pub Date : 2019-01-01 Oyebola Oluwagbemiga Sonuga, Fayeofori Mpakaboari Abbiyesuku, Kayode Samson Adedapo, Ayobola Abimbola Sonuga
Background: Diabetes mellitus and cardiovascular diseases significantly contribute to medical morbidity and mortality worldwide, especially in developing countries like Nigeria. Insulin resistance, a characteristic finding of type 2 diabetics and their offspring, is associated with an abnormal lipid metabolism and cardiovascular disease. Aims: This study therefore aims to determine the pattern of lipid
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Precipitating Factors for Diabetic Ketoacidosis among Patients with Type 1 Diabetes Mellitus: The Effect of Socioeconomic Status Int. J. Diabetes Metab. Pub Date : 2019-01-01 Ahmed Hakim Al-Obaidi, Haider Ayad Alidrisi, Abbas Ali Mansour
Background: Diabetic ketoacidosis (DKA) is one of the life-threatening acute complications of diabetes mellitus that mainly occurs in type 1 diabetes mellitus (T1DM). This study aimed to determine the socioeconomic factors associated with DKA in patients with T1DM in Basrah. Methods: A cross-sectional study including patients with T1DM who were admitted due to DKA or any other complaint in any of the
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Prevalence of Microvascular Complications in Type 2 Diabetics Attending a Primary Healthcare Centre in Sudan Int. J. Diabetes Metab. Pub Date : 2019-01-01 Mustafa Hussein, Sami Menasri
Background: Diabetes mellitus (DM) has become a global public health challenge. The increasing urbanisation and the significant lifestyle changes have resulted in an unprecedented rise in the rates of type 2 DM and, consequently, its microvascular complications which are the major outcome of the disease. It is the low- and middle-income countries where 80% of the diabetic patients live that face the
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Prediabetes Risk Assessment among Nurses Recruited in a Dubai Local Government Hospital: A Cross-Sectional Study Int. J. Diabetes Metab. Pub Date : 2019-01-01 Khadija Abdullah, Susan Jacob, Hamid Y. Hussain, Nezar Ahmed Salim
Background: Nurses constitute half of the health workforce; their health could be at risk for chronic diseases, such as prediabetes and diabetes, as well as other occupational hazards, such as nurses’ stress. Health promotion, possibly workplace based, presents opportunities to safeguard the health of nurses. Using a prediabetes risk assessment tool for screening the nurses is important to ensure that
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Association between Lipid Profiles and Renal Functions among Adults with Type 2 Diabetes Int. J. Diabetes Metab. Pub Date : 2019-01-01 Salih Awla Hamzah
Introduction: Type 2 diabetes mellitus (T2DM) affects renal functions and lipid profiles of patients. Objectives: In this study, 100 patients (65 females, 35 males) with T2DM were evaluated to determine whether renal function characteristics and lipid profiles are associated with T2DM. Methods: Blood samples were collected from all patients with T2DM, and the levels of hemoglobin A1c (HbA1c), blood
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Editorial Int. J. Diabetes Metab. Pub Date : 2019-01-01 Fatheya F. Alawadi
I would like to welcome you all to this edition of IJD: International Journal of Diabetes and Metabolism. Diabetes is clearly attracting the major interest of researchers across the globe, and this is reflected in the fact that all the studies published in this issue are diabetes related. However, this comes as no surprise with the continuous rise in global diabetes prevalence. I am delighted that
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Preventing Diabetes Mellitus in Nigeria: Effect of Physical Exercise, Appropriate Diet, and Lifestyle Modification Int. J. Diabetes Metab. Pub Date : 2019-01-01 Olasunkanmi R. Adeleke, George O. Ayenigbara
In this systematic review, we explored the effects of physical activity, diet, and lifestyle on the prevention of diabetes mellitus in Nigeria. Diabetes is an autoimmune disease which occurs when the body does not produce or respond properly to insulin, a hormone essential for daily life. Diabetes is an incurable disease, which has no racial, social, or sex barrier. The risk factors include a poor
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The Effect of Depression on Poor Glycemic Control in Adults with Type 2 Diabetes: The Mediating Roles of Self-Efficacy and Self-Management Behaviors Int. J. Diabetes Metab. Pub Date : 2019-01-01 Golnaz Azami, Kim Lam Soh, Shariff-Ghazali Sazlina, Md. Said Salmiah, Afra Khosravi, Sanaz Aazami, Reza Valizadeh
Background: High levels of depression and poor self-efficacy and self-management are associated with worse glycemic control, but the linkage and pathway between these variables are poorly understood. We conducted this study to investigate the hypothesis that self-efficacy and self-management mediate the influence of depression on poor glycemic control. Methods: We studied a purposive sample of 142
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An Appraisal of a Systematic Review and Meta-Analysis of Randomized Clinical Trials on the Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors as an Adjunct to Insulin Therapy in Type 1 Diabetes Patients Int. J. Diabetes Metab. Pub Date : 2019-01-01 Sumanta Saha
Dear Editor, I am writing to share a critique about a highly cited recently published (2018) paper on the efficacy and safety of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in type 1 diabetes patients [1]. In contemporary medicine, when the knowledge in this milieu is not parallelly apparent as in type 2 diabetes mellitus patients, the paper proves vital in addressing the evidence gap [1]. I
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The Impact of Adiponectin Gene Polymorphisms on the Insulin Resistance Index in Patients with Diabetes and Newly Diagnosed Type 2 Diabetes Int. J. Diabetes Metab. Pub Date : 2019-01-01 Helma Karimi, Masoumeh Nezhadali, Mehdi Hedayati, Maryam Mahdavi, Sara Sheikholeslami
Background: Some adipokine hormones can affect both human and animal models of insulin resistance. Aims: This study was conducted to assess the association between rs17300539 and rs266729 of the adiponectin gene and insulin resistance and anthropometric and metabolic characteristics in impaired fasting glucose (IFG)/type 2 diabetes mellitus (T2DM) and nondiabetic participants. Methods: DNA was extracted
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Factors Associated with Insulin Nonadherence in Type 1 Diabetes Mellitus Patients in Mexico Int. J. Diabetes Metab. Pub Date : 2019-01-01 Paloma Almeda-Valdes, Josefa Palacio Ríofrio, K. Walkiria Zamudio Coronado, David Rivera de la Parra, Janneth Bermeo Cabrera, Francisco J. Gómez-Pérez, Carlos A. Aguilar-Salinas, Roopa Mehta
Background: Lack of adherence to insulin therapy is common among patients with type 1 diabetes. Factors associated with insulin omission in adult persons with type 1 diabetes in Latin America have not been studied in detail. Objectives: To investigate factors associated with insulin nonadherence including the presence of psychological disorders (disordered eating behaviors and depression) in adult
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Pharmacist’s Intervention on Pill Burden Effects on the Health-Related Quality of Life of Elderly Diabetic Patients in a Tertiary Hospital in Southwestern Nigeria Int. J. Diabetes Metab. Pub Date : 2019-01-01 Winifred Aitalegbe Ojieabu
Background: Diabetes and its associated complications take a toll on the elderly. It is known that medication burden could reduce patients’ adherence, which in turn impacts negatively on the health-related quality of life (HRQOL) of those suffering from chronic diseases. Studies have been conducted on HRQOL and its associated factors among diabetic patients but none has studied pill burden effects
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Analysis of Cardiovascular Fitness, Sleep Quality, Depression, Fatigue, and Quality of Life among Individuals with Respect to the Glycated Hemoglobin Level in Type 2 Diabetes Mellitus Int. J. Diabetes Metab. Pub Date : 2019-01-01 Swetank Pathak, Shweta Shenoy
Background: Diabetes as a metabolic disorder can affect the various systems of the body, resulting in a decrease in cardiovascular fitness, sleep quality, and life quality that can lead to depression and fatigue. Aim: We analyzed cardiovascular fitness, sleep quality, depression, fatigue, and quality of life among individuals with a glycated hemoglobin (HBA1C) level >6.5% and ≤6.5%, as well as the
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A Systematic Review and Meta-Analysis of Randomised Controlled Trials, Contrasting the Safety Profile between Sodium-Glucose Cotransporter-2 Inhibitors and Placebo in Type 1 Diabetes Mellitus Patients Int. J. Diabetes Metab. Pub Date : 2019-01-01 Sumanta Saha, Sujata Saha
Background: This study aims to contrast the side effects of treatment with sodium-glucose cotransporter-2 inhibitors (SGLT2i) and placebo in insulin-treated adult type 1 diabetes mellitus (T1DM) patients. Methods: Double-blinded randomized controlled trials that compare the above outcome were searched in electronic databases. Next, the risk of bias in eligible studies was assessed, and comparable outcomes
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Impact of Dipeptidyl Peptidase-4 Inhibitors on Glycemic Control and Cardiovascular Safety with Adherence: An Overview Int. J. Diabetes Metab. Pub Date : 2019-01-01 Keerthanaa Bhavadasan, Ann Merry Davis, Bharathi Kolanthavel
Diabetes is a ubiquitous chronic disease worldwide. The prevalence is expected to increase further to 9.9% by the year 2045. Dipeptidyl peptidase-4 (DPP-4) inhibitors, also called as gliptins, act as incretin enhancers. They inhibit glucagon secretion and arouse postprandial insulin secretion, both in a glucose-dependent mode. In 2006, sitagliptin was approved as a first DPP-4 inhibitor in the treatment
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Use of SGLT2 Inhibitors in Diabetic Renal Transplant Recipients: A Mixed Method Exploratory Exercise Int. J. Diabetes Metab. Pub Date : 2018-01-01 Salem A. Beshyah, Anas S. Beshyah, Waleed S. Beshyah, Salim Yaghi
Background: Diabetes is the leading cause of end-stage renal disease (ESRD) worldwide. Also, diabetes is prevalent in kidney transplant recipients for nondiabetic reasons. Methodology: We used a mixed method methodology, including a case report, surveys of physicians’ opinions, and a review of the literature. Results: (A) A 58-year-old retired police officer was seen at the diabetes clinic in October
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ENPP1 K121Q Functional Variant Enhances Susceptibility to Insulin Resistance and Dyslipidemia with Metabolic Syndrome in Asian Indians Int. J. Diabetes Metab. Pub Date : 2018-01-01 Gurjit K. Bhatti, Sumanpreet Kaur, Rajesh Vijayvergiya, Sanjay K. Bhadada, Sarabjit S. Mastana, Bhupinder Singh, Jasvinder S. Bhatti
Background: Ectonucleotide pyrophosphatase/phosphodiesterase1 (ENPP1/PC-1) is a key modulator of the insulin signaling pathway, and its common variant, K121Q, increases the susceptibility to diabetes and cardiovascular diseases. Objectives: The main objective of the present study was to investigate the association of ENPP1 K121Q polymorphism with the pathophysiology of metabolic syndrome (MetS) in
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Paraoxonase 1 Gene Polymorphisms (Q192R and L55M) Are Associated with Coronary Artery Disease Susceptibility in Asian Indians Int. J. Diabetes Metab. Pub Date : 2018-01-01 Sumanpreet Kaur, Gurjit Kaur Bhatti, Rajesh Vijayvergiya, Puneetpal Singh, Sarabjit Singh Mastana, Rupinder Tewari, Jasvinder Singh Bhatti
Background: Coronary artery disease (CAD) is a complex metabolic disorder in which lifestyle and genetic factors are known to play key roles in pathogenesis. The paraoxonase 1 (PON1) enzyme has a defensive effect against CAD progression, as it safeguards low-density lipoproteins (LDLs) from oxidative modifications. The most extensively studied genetic variants in the PON1 gene are Q192R and L55M, which
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Prevalence of Type 2 Diabetes Mellitus among Hepatitis C Virus-Infected Patients: A Systematic Review and Meta-Analysis Int. J. Diabetes Metab. Pub Date : 2018-01-01 Sintayehu Ambachew, Setegn Eshetie, Demeke Geremew, Aklilu Endalamaw, Mulugeta Melku
Background: The ever-increasing global prevalence of hepatitis C infection is fueling the burden of diabetes mellitus, which exacerbates various complications and may be a cause of death of millions of people. Several studies have reported that hepatitis C virus infection is an important risk factor for the development of diabetes mellitus. However, fragmented studies have reported variable and inconsistent
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International Journal of Diabetes and Metabolism Returns Int. J. Diabetes Metab. Pub Date : 2018-01-01 Dima Abdelmannan, Muhammad Hamed Farooqi , Salem A. Beshyah
We are delighted to announce the return of the International Journal of Diabetes and Metabolism (IJDM) having been interrupted for 2 years. The present first issue will be the first issue under the auspices of the Medical Education Center of Dubai Health Authority, Dubai, UAE. We are proud to build upon the journal’s previous track record under the United Arab Emirates University, Al Ain between 2001
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Prevalence of Adult-Onset Hypogonadism and Erectile Dysfunction in Males with Prediabetes Int. J. Diabetes Metab. Pub Date : 2018-01-01 Rajesh Rajput, Saurav Banerjee
Background: The prevalence of prediabetes is high globally; however, few studies have investigated the prevalence of adult-onset hypogonadism (AOH) and erectile dysfunction (ED) in men with prediabetes, and there is no study from India. Aims: The aim of this study was to evaluate the prevalence of AOH and ED in men with prediabetes and to correlate the risk of testosterone deficiency with prediabetes
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Allele-Specific Detection of SLC22A2 rs316019 Variants Associated with Metformin Disposition through the Kidney Int. J. Diabetes Metab. Pub Date : 2018-01-01 Tasmia Islam, Md. Siddiqur Rahman, Nilanjana Paul, Sharif Akhteruzzaman, Abu Ashfaqur Sajib
Background: Metformin is prescribed as a first-line drug to treat type 2 diabetes. It is excreted directly and primarily through the SLC22A2 gene-encoded OCT2 transporter in the kidney. rs316019 (c.808G>T, p.270A>S) is the most common variant of SLC22A2, which affects its capacity to clear metformin from the body. Metformin increases the plasma lactate level in a concentration-dependent manner by inhibiting