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Machine Learning-Based Prediction of Hashimoto Thyroiditis Development Risk medRxiv. Endocrinol. Pub Date : 2024-03-16 Luis Jesuino de Oliveira Andrade, Gabriela Correia Matos de Oliveira, Luisa Correia Matos de Oliveira, Alcina Maria Vinhaes Bittencourt, Luis Matos de Oliveira
Introduction: Hashimoto Thyroiditis (HT) is a prevalent autoimmune disorder impacting thyroid function. Early detection allows for timely intervention and improved patient outcomes. Traditional diagnostic methods rely on clinical presentation and antibody testing, lacking a robust risk prediction tool. Objective: To develop a high-precision machine learning (ML) model for predicting the risk of HT
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BMI Variability and Cardiovascular Outcomes Within Clinical Trial and Real-World Environments in Type 2 Diabetes: An IMI2 SOPHIA study medRxiv. Endocrinol. Pub Date : 2024-03-16 Robert J Massey, Adem Y Dawed, Yu Chen, Marine Panova-Noeva, Michaela Mattheus, Moneeza K Siddiqui, Nanette Cathrin Schloot, Antonio Ceriello, Ewan R Pearson
Aims: BMI variability has been associated with increased cardiovascular disease risk in individuals with type 2 diabetes, however comparison between clinical studies and real–world observational evidence has been lacking. Furthermore, it is not known whether BMI variability has an effect independent of HbA1c variability. Methods and Results: We investigated the association between BMI variability and
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Comparative cardiovascular safety of romosozumab versus bisphosphonates in Japanese patients with osteoporosis A new-user, active comparator design with instrumental variable analyses medRxiv. Endocrinol. Pub Date : 2024-03-15 Ryoji Tominaga, Tatsuyoshi Ikenoue, Ryosuke Ishii, Kakuya Niihata, Tetsuro Aita, Tadahisa Okuda, Sayaka Shimizu, Masataka Taguri, Noriaki Kurita
Importance Romosozumab, a novel anti-osteoporotic agent, confers marked improvement in bone mineral density; however, its cardiovascular safety remains a concern. Objective To compare the cardiovascular safety of romosozumab to bisphosphonates in patients with osteoporosis. Design A cohort study using a new-user, active comparator design. Setting Medical facilities, including clinics and hospitals
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Predictive Modeling for Diabetes Using GraphLIME medRxiv. Endocrinol. Pub Date : 2024-03-15 Flavia Costi, Darian Onchis, Eduard Hogea, Codruta Istin
The purpose of this paper is to present a detailed investigation of the advantages of employing GraphLIME (Local Interpretable Model Explanations for Graph Neural Networks) for the trustworthy prediction of diabetes mellitus. Our pursuit involves identifying the strengths of GraphLIME combined with the attention-mechanism over the standard coupling of deep learning neural networks with the original
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Insulin resistance, and not β-cell impairment, mediates association between Mycobacterium tuberculosis sensitization and type II diabetes mellitus among US adults. medRxiv. Endocrinol. Pub Date : 2024-03-15 Itai M Magodoro, Aloice Aluoch, Brian Claggett, Moffat J. Nyirenda, Mark J Siedner, Katalin Andrea A Wilkinson, Robert J Wilkinson, Ntobeko AB Ntusi
Type 2 diabetes mellitus (T2DM) may be a long-term sequela of infection with Mycobacterium tuberculosis (M.tb) by mechanisms that remain to be fully explained. We evaluated the association between M.tb sensitization and T2DM among U.S adults and, via formal mediation analysis, the extent to which this association is mediated by insulin resistance and/or β-cell failure. These evaluations accounted for
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Associations of HIV and prevalent type 2 diabetes mellitus in the context of obesity in South Africa. medRxiv. Endocrinol. Pub Date : 2024-03-14 Itai M Magodoro, Alison C castle, Ndumiso Tshuma, Julia H. Goedecke, Ronel Sewpaul, Justen Manasa, Jennifer Manne-Goehler, Ntobeko AB Ntusi, Mark J Siedner
It is unclear how rising obesity among people with HIV (PWH) in sub-Saharan Africa (SSA) impacts their risk of type 2 diabetes mellitus (diabetes). Using a South African national cross-sectional sample of adult PWH and their peers without HIV (PWOH), we examined the associations between HIV and prevalent diabetes across the spectrum of body mass index (BMI), waist circumference (WC) and waist-to-height
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Personalized phosphoproteomics of skeletal muscle insulin resistance and exercise links MINDY1 to insulin action medRxiv. Endocrinol. Pub Date : 2024-03-13 Elise J Needham, Janne R. Hingst, Johan D. Onslev, Alexis Diaz-Vegas, Magnus R. Leandersson, Kristen Cooke, Guang Yang, Jonas M. Kristensen, Kohei Kido, Benjamin L. Parker, Kurt Højlund, Erik A. Richter, Christian Pehmøller, Sean J. Humphrey, David E. James, Jørgen F.P. Wojtaszewski
Type 2 diabetes is preceded by a defective insulin response, yet our knowledge of the precise mechanisms is incomplete. Here, we investigate how insulin resistance alters signalling responses in skeletal muscle and how this is modified by exercise. We measured parallel phenotypes and phosphoproteomes of insulin resistant and insulin sensitive individuals as they responded to exercise and insulin (n=19
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Prevalence of differences of sex development in Switzerland from 2000-2019 medRxiv. Endocrinol. Pub Date : 2024-03-13 Sara Andrea Metzger, Grit Sommer, Christa E Flueck, Swiss DSD Cohort Study Group
Objective: Reliable data on prevalence of rare differences of sex development (DSD) are lacking. We aimed to estimate population-based prevalence of DSD in Switzerland. Design: Retrospective population-based study including individuals with DSD according to Chicago Consensus, born in Switzerland from 2000-2019. Methods: Endocrine care centers in all ten Swiss Children's Hospitals and eight private
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Evaluating the feasibility of study methods for a future trial-based economic evaluation of a multistage shared decision-making program for type 2 diabetes mellitus: protocol for a cluster-randomized controlled pilot study medRxiv. Endocrinol. Pub Date : 2024-03-13 Anna Tichler, Dorijn F.L. Hertroijs, Ghislaine A.P.G. van Mastrigt, Martijn C.G.J. Brouwers, Dirk Ruwaard, Arianne M.J. Elissen
Introduction We developed a multistage shared decision-making program for type 2 diabetes that aims to support person-centered type 2 diabetes management in primary care. The program consists of an online patient decision aid, a preparatory consult for patients, and interprofessional training for healthcare professionals. The short- and long-term effectiveness of the multistage shared decision-making
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Vitamin D for glycemic control following an acute pulmonary exacerbation: A secondary analysis of a multicenter, double-blind, randomized, placebo-controlled trial in adults with cystic fibrosis medRxiv. Endocrinol. Pub Date : 2024-03-10 Alisa K Sivapiromrat, William R Hunt, Jessica A Alvarez, Thomas R Ziegler, Vin Tangpricha
Individuals with cystic fibrosis (CF) often incur damage to pancreatic tissue due to a dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) protein, leading to altered chloride transport on epithelial surfaces and subsequent development of cystic fibrosis-related diabetes (CFRD). Vitamin D deficiency has been associated with the development of CFRD. This was a secondary analysis
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Blood methylation pattern reflects epigenetic remodelling in adipose tissue after bariatric surgery medRxiv. Endocrinol. Pub Date : 2024-03-09 Luise Müller, Anne Hoffmann, Stephan H. Bernhart, Adhideb Ghosh, Jiawei Zhong, Tobias Hagemann, Wenfei Sun, Hua Dong, Falko Noé, Christian Wolfrum, Arne Dietrich, Michael Stumvoll, Lucas Massier, Matthias Blüher, Peter Kovacs, Rima Chakaroun, Maria Keller
Background Studies on DNA methylation following bariatric surgery have primarily focused on blood cells, while it is unclear to which extend it may reflect DNA methylation profiles in specific metabolically relevant organs such as adipose tissue (AT). Here, we investigated whether adipose tissue depots specific methylation changes after bariatric surgery are mirrored in blood. Methods Using Illumina
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Various types of circulating small non-coding RNAs associate with kidney function in people with type 2 diabetes medRxiv. Endocrinol. Pub Date : 2024-03-07 Leen M 't Hart, Gerard A Bouland, Juliette A de Klerk, Steve J Cramer, Janneke H.D. Peerlings, Steve J Cramer, Roel Bijkerk, Joline W.J. Beulens, Roderick C Slieker
Introduction Micro- and macrovascular complications are common among persons with type 2 diabetes. Recently there has been growing interest to investigate the potential of circulating small non-coding RNAs (sncRNAs) as biomarkers and drivers of the development of diabetic complications. In this study we investigate to what extent circulating sncRNAs levels associate with prevalent diabetic kidney disease
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Critical Role for 24-Hydroxylation in Homeostatic Regulation of Vitamin D Metabolism medRxiv. Endocrinol. Pub Date : 2024-03-07 Zhinous Shahidzadeh Yazdi, Elizabeth A Streeten, Hilary B Whitlatch, May E Montasser, Amber L Beitelshees, Simeon I Taylor
Context. The body has evolved homeostatic mechanisms to maintain free levels of Ca+2 and 1,25-dihydroxyvitamin D [1,25(OH)2D] within narrow physiological ranges. Clinical guidelines emphasize important contributions of PTH in maintaining this homeostasis. Objective. To investigate mechanisms of homeostatic regulation of vitamin D (VitD) metabolism and to apply mechanistic insights to improve clinical
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Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease medRxiv. Endocrinol. Pub Date : 2024-03-05 Jelena Kolic, WenQing Grace Sun, Haoning Howard Cen, Jessica Ewald, Jason C. Rogalski, Shugo Sasaki, Han Sun, Varsha Rajesh, Yi Han Xia, Renata Moravcova, Søs Skovsø, Aliya F Spigelman, Jocelyn E Manning Fox, James Lyon, Leanne Beet, Jianguo Xia, Francis C Lynn, Anna L Gloyn, Leonard J Foster, Patrick E MacDonald, James D Johnson
Population level variation and molecular mechanisms behind insulin secretion in response to carbohydrate, protein, and fat remain uncharacterized despite ramifications for personalized nutrition. Here, we define prototypical insulin secretion dynamics in response to the three macronutrients in islets from 140 cadaveric donors, including those diagnosed with type 2 diabetes. While islets from the majority
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T2DFitTailor: A tool for type 2 diabetes patients to tailor exercise plan medRxiv. Endocrinol. Pub Date : 2024-03-04 Cheng Liu, Xinyu Hou, Bingxiang Xu, Tiemin Liu, Ru Wang
Type 2 Diabetes (T2D) poses a formidable global health challenge, with its escalating prevalence contributing significantly to increased morbidity, mortality, and healthcare costs. This chronic condition, characterized by insulin resistance and hyperglycemia, leads to a plethora of complications, intensifying its societal and economic impact. Exercise, as a fundamental element of T2D management, is
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Hyperglycemia-induced cathepsin L maturation: Linking to diabetic comorbidities and COVID-19 mortality medRxiv. Endocrinol. Pub Date : 2024-03-04 Qiong He, Miao-Miao Zhao, Ming-Jia Li, Xiao-Ya Li, Jian-Min Jin, Ying-Mei Feng, Li Zhang, Wei Jin Huang, Fangyuan Yang, Jin-Kui Yang
Diabetes, a prevalent chronic condition, significantly increases the risk of mortality from COVID-19, yet the underlying mechanisms remain elusive. Emerging evidence implicates Cathepsin L (CTSL) in diabetic complications, including nephropathy and retinopathy. Our previous research identified CTSL as a pivotal protease promoting SARS-CoV-2 infection. Here, we demonstrate elevated blood CTSL levels
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Perceived risk of type 2 diabetes: Using linked genomic, clinical and questionnaire data to understand the potential use of genetic risk tools in British South Asians medRxiv. Endocrinol. Pub Date : 2024-03-02 Jing Hui Law, Daniel Stow, Sam Hodgson, Genes & Health Research Team, David A van Heel, William G Newman, Magda Osman, Sarah Finer
Background Despite growing interest surrounding the integration of genetic risk tools such as polygenic risk scores (PRSs) into routine care for early disease identification and management, major questions remain about whether and how these tools are to be implemented at-scale. Many interventions have explored their use in encouraging the adoption of preventative health behaviours - yet existing evidence
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Plasma proteomic signatures of adiposity are associated with cardiovascular risk factors and type 2 diabetes risk in a multi-ethnic Asian population. medRxiv. Endocrinol. Pub Date : 2024-03-01 Charlie Lim, Bige Ozkan, Yujian Liang, Jiali Yao, Nang Ei Ei Khaing, Mary R. Rooney, Chiadi E. Ndumele, E Shyong Tai, Josef Coresh, Xueling Sim, Rob M. van Dam
The molecular mechanisms connecting obesity and cardiometabolic diseases are not fully understood. We evaluated the associations between body mass index (BMI), waist circumference (WC), and ~5,000 plasma proteins in the Singapore Multi-Ethnic Cohort (MEC1). Among 410 BMI-associated and 385 WC-associated proteins, we identified protein signatures of BMI and WC and validated them in an independent dataset
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Erectile Dysfunction in Men with and without Type 2 Diabetes Mellitus at Livingstone University Teaching Hospital, Zambia: A cross-sectional study medRxiv. Endocrinol. Pub Date : 2024-02-29 Lweendo Muchaili, Benson Hamooya, Bislom Mweene, Sepiso Masenga
Abstract Background: Erectile dysfunction (ED) is frequently undiagnosed in males with type 2 diabetes mellitus (T2DM), despite its high prevalence. Early detection of ED in T2DM is crucial for effective treatment and prevention of severe complications such as cardiovascular events. This study explores the prevalence of ED and its associated factors in males with and without T2DM at Livingstone University
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Effect of neonatal BCG vaccination on the evolution of Hashimoto Thyroiditis medRxiv. Endocrinol. Pub Date : 2024-02-29 Kanhaiya Agrawal, Preetam Basak, Darshan Badal, Pinaki Dutta, Rama Walia, NARESH SACHDEVA
Background: Hashimoto thyroiditis (HT) involves the autoimmune destruction of thyrocytes with the presence of anti-thyroid peroxidase (TPO) and/or anti-thyroglobulin (TG) antibodies. In autoimmune diseases, an immunomodulatory role of Bacillus Calmette-Guerin (BCG) vaccination has been reported with decreased autoantibody production and induction of regulatory T cells. We hypothesize that a decline
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Structured Diabetes Education: virtual access was as effective as face-to-face access to a structured diabetes education programme (EMPOWER T2n) for people with type 2 diabetes in England. medRxiv. Endocrinol. Pub Date : 2024-02-28 Donna Sutton, Richard Palin, Jim Swift, Chris Barker, Claire Pridige, Sudip Ghosh
Introduction & objectives: Structured diabetes education (SDE) is an evidence-based intervention for type 2 diabetes. The goal of this study was to compare SDE whether accessed face to face or virtually and determine if any differences existed in key endpoint attainment. This study helps address the absence of evaluations comparing these access modalities. Research design and methods: All data were
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Ethnic differences in the manifestation of early-onset type 2 diabetes medRxiv. Endocrinol. Pub Date : 2024-02-27 Davis Kibirige, Anita V Hill, Jean Claude Katte, Isaac Sekitoleko, William Lumu, Julieanne Knupp, Steven Squires, Andrew Hattersley, Liam Smeeth, Angus G Jones, Moffat J Nyirenda
Aims/Hypothesis We undertook phenotypic characterization of early-onset and late-onset type 2 diabetes (T2D) in adult Black African and White European populations with recently diagnosed T2D to explore ethnic differences in the manifestation of early-onset T2D. Methods Using the Uganda Diabetes Phenotype study cohort of 500 adult Ugandans and the UK StartRight study cohort of 714 White Europeans with
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“If I am free from diabetes, that itself will be the happiest thing”: A convergent mixed methods study of the lived experiences of young adults with type 2 diabetes in Mysore district, India medRxiv. Endocrinol. Pub Date : 2024-02-27 Nikhita Rani Gopisetty, Kiranmayee Muralidhar, Nagalambika Ningaiah, Rani Chinnappa, Mia Buono, Poornima Jaykrishna, Purnima Madhivanan, Sumedha Gupta Ariely, Eve S. Puffer
Type 2 diabetes (T2D) has been occurring at younger ages of onset around the world. India’s population accounts for nearly 20% of the global disease burden. This study investigated the occurrence of depressive symptoms and qualitatively explored the lived experiences of 20 young adults living with T2D under the age of 35. We conducted a convergent mixed-methods study with the Patient Health Questionnaire
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Bilateral aldosterone production is most common in primary aldosteronism found by screening within primary care medRxiv. Endocrinol. Pub Date : 2024-02-24 Nikita Makhnov, Jakob Skov, Fredrik Axling, Daniel Andernord, Mikael Bergenheim, Mauritz Waldén, Per Hellman
OBJECTIVE Primary aldosteronism (PA) is the most common cause of secondary hypertension, and implies high risk of cardiovascular complications. Previously, our group had screened 1181 unselected Swedish primary care hypertensive patients, to find PA prevalence of 4,5%. The current study describes results of further diagnostics and specific treatment of these PA patients. DESIGN Prospective evaluation
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Bicalutamide does not raise transaminases in comparison to alternative anti-androgen regimens among transfeminine adolescents and young adults: a retrospective cohort study medRxiv. Endocrinol. Pub Date : 2024-02-23 Katie Burgener, Brian DeBosch, Jinli Wang, Christopher Lewis, Cynthia J. Herrick
Background: Bicalutamide is a potential anti-androgen for transgender individuals with feminizing embodiment goals, but use has been limited because of hepatotoxicity in cisgender men with prostate cancer. This study compared transaminase changes in transfeminine adolescents and young adults (AYA) using low-dose bicalutamide with individuals using other methods of androgen blockade. Methods: A retrospective
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Ursodeoxycholic acid for trans intestinal cholesterol excretion stimulation: a randomized placebo controlled cross-over study. medRxiv. Endocrinol. Pub Date : 2024-02-23 Reindert Ferdinand Oostveen, Yannick Kaiser, Merel L. Hartgers, Emma C.E. Meessen, Aldo Grefhorst, G. Kees Hovingh, Folkert Kuipers, Erik SG Stroes, Bert Groen, Laurens F. Reeskamp
Objective: The Trans Intestinal Cholesterol Excretion (TICE) pathway is a potential therapeutic target to reduce plasma low-density lipoprotein (LDL) cholesterol levels. TICE encompasses the direct excretion of cholesterol by enterocytes into feces. In mice TICE has been shown to be stimulated by a hydrophilic bile acid pool, resulting in increased fecal neutral sterols (FNS) loss and reduced plasma
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Higher FSH Level is Associated with Increased Risk of Incident Hip Fracture in Older Adults, Independent of Sex Hormone Levels medRxiv. Endocrinol. Pub Date : 2024-02-20 Eileen H Koh, Susan K Ewing, Sigurdur Sigurdsson, Vilmundur Gudnason, Trisha F Hue, Eric Vittinghoff, Claes Ohlsson, Asa Tivesten, Louise Grahnemo, Tony Yuen, Mone Zaidi, Clifford J Rosen, Ann V Schwartz, Anne L Schafer
Context: Higher levels of follicle stimulating hormone (FSH) are associated with bone loss among women during the perimenopausal transition and among older men, independent of estradiol and testosterone levels, but it is unknown whether higher FSH is an independent risk factor for fracture. Objective: Determine whether baseline FSH level predicts subsequent hip fracture in older adults. Setting, Design
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Diabetics in the United Arab Emirates at higher risk of foot ulceration- Clinical Implications from Kinetics at Ankle Joint medRxiv. Endocrinol. Pub Date : 2024-02-20 Animesh Hazari, Praveen Kumar, Shashi Kumar
Introduction The prevalence of diabetes mellitus in the United Arab Emirates stands significantly high. Considering the etiopathogenesis for diabetic foot ulcers, studies suggest that increased plantar pressure, also referred to as the peak plantar pressure beyond a threshold value leads to the breakdown of skin and thus causes an ulcer. The accurate analysis of ground reaction force and peak plantar
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AGO2 protein:A Key Enzyme in the miRNA Pathway as a Diagnostic and Prognostic Biomarker in Adrenocortical Carcinoma. medRxiv. Endocrinol. Pub Date : 2024-02-20 Anila Hashmi, Gyorgy Hutvagner, Stan Sidhu, Alexander Papachristos
Context: Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy. Current treatment algorithms are associated with diagnostic limitations, high recurrence rates and poor prognosis. Identifying specific biomarkers that facilitate accurate diagnosis and provide prognostic insights could significantly enhance the patient outcomes in ACC. Objective: To investigate whether microRNA machinery
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External validation of Finnish Diabetes Risk Score (FINDRISC) and Latin American FINDRISC for screening of undiagnosed dysglycemia: analysis in a Peruvian hospital health care workers sample. medRxiv. Endocrinol. Pub Date : 2024-02-18 Marlon Yovera-Aldana, Edward Mezones-Holguín, Rosa Agüero-Zamora, Lucy Damas-Casani, Becky Uriol-Llanos, Frank Espinoza-Morales, Percy Soto-Becerra, Ray Ticse-Aguirre
Aims To evaluate the external validity of Finnish diabetes risk score (FINDRISC) and Latin American FINDRISC (LAFINDRISC) for undiagnosed dysglycemia in hospital health care workers. Methods We carried out a cross-sectional study on health workers without a prior history of diabetes mellitus (DM). Undiagnosed dysglycemia (prediabetes or diabetes mellitus) was defined using fasting glucose and two-hour
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Microvascular insulin resistance associates with enhanced muscle glucose disposal in CD36 deficiency. medRxiv. Endocrinol. Pub Date : 2024-02-18 Cyndya A Shibao, Vivek S. Peche, Ian M. Williams, Dmitri Samovski, Terri A. Pietka, Naji N. Abumrad, Eric Gamazon, Ira Goldberg, David Wasserman, Nada A. Abumrad
Dysfunction of endothelial insulin delivery to muscle associates with insulin resistance. CD36, a fatty acid transporter and modulator of insulin signaling is abundant in endothelial cells, especially in capillaries. Humans with inherited 50% reduction in CD36 expression have endothelial dysfunction but whether it is associated with insulin resistance is unclear. Using hyperinsulinemic/euglycemic clamps
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Exploring the Prevalence and Components of Metabolic Syndrome in Sub-Saharan African Type 2 Diabetes Mellitus Patients: A Systematic Review and Meta-Analysis medRxiv. Endocrinol. Pub Date : 2024-02-17 Nelson Musilanga, Hussein Nasib, Given Jackson, Frank Shayo, Clarkson Nhanga, Saleh Girukwigomba, Ambokile Mwakibolwa, Samson Henry, Keneth Kijusya, Edgar Msonge
Background Type 2 diabetes mellitus and metabolic syndrome represent two closely intertwined public health challenges that have reached alarming epidemic proportions in low- and middle-income countries, particularly in sub-Saharan Africa. Therefore, the current study aimed to determine the weighted pooled prevalence of metabolic syndrome and its components among individuals with type 2 diabetes mellitus
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Prevalence of Microvascular Complications and Associated Risk Factors among Diabetes Mellitus Patients attending Nyeri County Referral Hospital, Kenya: a cross-sectional Study medRxiv. Endocrinol. Pub Date : 2024-02-17 Rachael Ireri, Gideon Kikuvi, susan Mambo, besty cheriro
Microvascular complications are one of the major causes of morbidity and mortality worldwide among patients with diabetes mellitus (DM). In Kenya, Nyeri County has the highest prevalence of diabetes mellitus compared to other counties. More than 50% of Nyeri County Referral Hospital (NCRH) admissions result from non-communicable diseases (NCDs) and over 55% of hospital deaths are attributable to NCDs
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Meta-analysis comparing the effect of combined acupuncture plus statin therapy versus statin therapy alone on lipid levels of patients with angina pectoris of coronary heart disease medRxiv. Endocrinol. Pub Date : 2024-02-16 Zhaobo Yan, Mailan Liu, xianming Wu, Jiaojiao Xiong, Zhihong Yang, Ning Zhang, Xiaofang Yang, Mi Liu
ABSTRACT Objectives Establish clinical evidence regarding acupuncture combined with statin for blood lipid control in patients with angina pectoris (AP) of coronary heart disease (CHD) by systematically analyzing data from all available studies. Design A systematic review and meta-analysis. Data sources The literature search involved eight databases (China National Knowledge Infrastructure, Chinese
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Cohort profile: The Nanjing Diabetes Cohort database – a population-based surveillance cohort medRxiv. Endocrinol. Pub Date : 2024-02-14 Wei Feng, Yuechuchu Yin, Chunyan Gu, Yuan Mu, Duxiao Zhang, Zhenhuan Tao, Weidong Yin, Xin Zhang, Yun Yu, Jie Hu, Cheng Wan, Yun Liu
Purpose: To study epidemiology, complications, risk factors, clinical course and treatment patterns of diabetes, the Nanjing Diabetes Cohort (NDC) was established using anonymized electronic medical records from 650 hospitals and primary cares since 2020. This cohort provides important opportunities for healthcare professionals treating patients with diabetes. Participants: Diabetes was defined as
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Association of multidrug-resistant bacteria and clinical outcomes in patients with infected diabetic foot in a Peruvian Hospital: A retrospective cohort analysis medRxiv. Endocrinol. Pub Date : 2024-02-13 Marlon Yovera-Aldana, Paola Sifuentes-Hermenegildo, Martha Sofia Cervera-Ocaña, Edward Mezones-Holguin
Objective To evaluate the association of multidrug-resistant bacteria (MDRB) and adverse clinical outcomes in patients with infected diabetic foot (IDF) in a Peruvian hospital. Materials and Methods This retrospective cohort study evaluated patients treated in the Diabetic Foot Unit of a General Hospital in Lima, Peru. MDRB was based on resistance to more than two pharmacological groups across six
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Association between altitude and death from COVID-19 in subjects with diabetes mellitus during the first wave: cross sectional study of the National Death Index medRxiv. Endocrinol. Pub Date : 2024-02-13 Raúl Manuel Ambrosio-Ojose, César Josué Casquero-Zambrano, Tery Vásquez-Hassinger, Marlon Yovera-Aldana
Background. In high Andean areas, there is greater insulin sensitivity which may be a protective factor against complications in subjects with diabetes mellitus. Objective: Determine the association between altitude of residence and death from COVID-19 in deaths with diabetes mellitus in Peru during the first wave.. Methods: We carried out a cross-sectional analysis of deaths registered in the National
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Sociodemographic and health-related differences in non-diabetic hyperglycaemia and undiagnosed type 2 diabetes in the Health Survey for England 2013-2019 medRxiv. Endocrinol. Pub Date : 2024-02-13 Emma Campbell, Ellie Macey, Caitlin Kneebone-Hopkins, Chris Shine, Vahe Nafilyan, Nicholas Brown, Martin White, Ross Jones, Kamlesh Khunti, Katie Finning
Background Type 2 diabetes is a leading cause of morbidity and mortality but is often undiagnosed. Non-diabetic hyperglycaemia increases T2D risk, and its prevalence is increasing. Understanding the scale of undiagnosed T2D and NDH and identifying at-risk groups is important for detection and intervention. Methods We used the 2013-2019 Health Survey for England, an annual, nationally representative
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Serum proteomic profiling of physical activity reveals CD300LG as a novel exerkine with a potential causal link to glucose homeostasis medRxiv. Endocrinol. Pub Date : 2024-02-12 Sindre Lee-Ødegård, Marit Hjorth, Thomas Olsen, Gunn-Helen Moen, Emily Daubney, David M Evans, Andrea L Hevener, Aldons J Lusis, Mingqi Zhou, Marcus M Seldin, Hooman Allayee, Jonas Krag Viken, Hanne Gulseth, Frode Norheim, Christian A Drevon, Kåre Inge Birkeland
Background: Physical activity has been associated with preventing the development of type 2 diabetes and atherosclerotic cardiovascular disease. However, our understanding of the precise molecular mechanisms underlying these effects remains incomplete and good biomarkers to objectively assess physical activity are lacking. Methods: We analyzed 3072 serum proteins in 26 men, normal weight or overweight
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USE OF MACHINE LEARNING TO PREDICT INDIVIDUAL POSTPRANDIAL GLYCEMIC RESPONSES TO FOOD AMONG INDIVIDUALS WITH TYPE 2 DIABETES IN INDIA medRxiv. Endocrinol. Pub Date : 2024-02-09 Niteesh K. Choudhry, Shweta Priyadarshini, Jaganath Swamy, Mridul Mehta
Background: Type 2 diabetes (DM2) is a leading cause of premature morbidity and mortality globally and affects more than 100 million people in the world's most populous country, India. Nutrition is a critical and evidence-based component of effective blood sugar control and most dietary advice emphasizes carbohydrate and calorie reduction. Emerging global evidence demonstrates marked inter-individual
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3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity medRxiv. Endocrinol. Pub Date : 2024-02-05 Khanh B Trang, Matthew C Pahl, James A Pippin, Chun Su, Sheridan H Littleton, Prabhat Sharma, Nikhil N Kulkarni, Louis R Ghanem, Natalie A Terry, Joan M O'Brien, Yadav Wagley, Kurt D Hankenson, Ashley Jermusyk, Jason W Hoskins, Laufey T Amundadottir, Mai Xu, Kevin M Brown, Stewart A Anderson, Wenli Yang, Paul M Titchenell, Patrick Seale, Laura Cook, Megan K Levings, Babette S Zemel, Alessandra Chesi
The prevalence of childhood obesity is increasing worldwide, along with the associated common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated by evidence for a strong genetic component, our prior genome–wide association study (GWAS) efforts for childhood obesity revealed 19 independent signals for the trait; however, the mechanism of action of these loci remains
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Non-autoimmune, lean diabetes in young people from Assam, India highlights the role of undernutrition in its aetiology – PHEnotypingNOrthEastINDianYoung type 2 diabetes (PHENOEINDY-2) medRxiv. Endocrinol. Pub Date : 2024-02-05 Anupam Dutta, Pranjal Kumar Dutta, Prasanta Dihingia, Sreemanta Madhab Baruah, Arpita Ray, Dattatrey S Bhat, Sonali Wagle Patki, Madhura Deshmukh, Rucha Wagh, Pradeep Tiwari, Rubina Mulchandani, Tanica Lyngdoh, Sanjeeb Kakati, Chittaranjan S Yajnik
Aims/hypothesis: Non-autoimmune diabetes in the young is believed to be driven by overweight-obesity and insulin resistance. However, it′s increasingly reported in undernourished people in the LMICs, including India. We hypothesized a role for undernutrition in the aetiology of non-autoimmune diabetes in impoverished young patients attending the Assam Medical College Hospital (AMCH), Dibrugarh (North-East
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Assessing the genetic contribution of cumulative behavioral factors associated with longitudinal type 2 diabetes risk highlights adiposity and the brain-metabolic axis medRxiv. Endocrinol. Pub Date : 2024-01-31 Nuno Carvalho, Yixuan He, Patrick Smadbeck, Jason Flannick, Josep Mercader, Miriam Udler, Arjun K Manrai, Jordi Merino, Chirag J Patel
While genetic factors, behavior, and environmental exposures form a complex web of interrelated associations in type 2 diabetes (T2D), their interaction is poorly understood. Here, using data from ~500K participants of the UK Biobank, we identify the genetic determinants of a polyexposure risk score (PXS) a new risk factor that consists of an accumulation of 25 associated individual-level behaviors
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New Reference Values for Thyroid Volume by Ultrasound in German Children and Adolescents Under Iodine-Sufficient Conditions from a Population-Based Study medRxiv. Endocrinol. Pub Date : 2024-01-31 Raphael Hirtz, Romma Thamm, Ronny Kuhnert, Klaus-Peter Liesenkoetter, Michael Thamm, Corinna Grasemann
Context: Reliable reference values for thyroid ultrasound measurements are essential to effectively guide individual diagnostics and direct health care measures at the population level, such as iodine fortification programs. However, the latest reference values for total thyroid volume (Tvol) provided by the WHO in 2004 only apply to the 6 to 12-year-old age group and are limited to countries with
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A Genetic Perspective on Diabetic Complications: A Mendelian Randomization Study on the Increased Risk of Cataracts in Type 1 Diabetes medRxiv. Endocrinol. Pub Date : 2024-01-30 Dongliang Pei, Shuyan Wang, Yuan Wang, Chenmin Sun
Background: The well-documented epidemiological link between type 1 diabetes and cataract is recognized. Yet, the question of a shared genetic foundation for these conditions, and the potential implication of a causal connection, is still an area of uncertainty. Methods: We utilized a two-sample Mendelian randomization approach to extract and analyze four GWAS datasets from public databases, aiming
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A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver medRxiv. Endocrinol. Pub Date : 2024-01-29 Andrew S Perry, Niran Hadad, Emeli Chatterjee, Maria Jimenez Ramos, Eric Farber-Eger, Rashedeh Roshani, Lindsay Stolze, Shilin Zhao, Liesbet Martens, Timothy Kendall, Tinne Thone, Kaushik Amancherla, Samuel Bailin, Curtis Gabriel, John Koethe, J Jeffrey Carr, James Greg Terry, Jane Freedman, Kahraman Tanriverdi, Eric Alsop, Kendall Van Keuren-Jensen, John Sauld, Gautam Mahajan, Sadiya Khan, Laura Colangelo
Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing in parallel with an obesity pandemic, calling for novel strategies for prevention and treatment. We defined a circulating proteome of human MASLD across ~7000 proteins in ~5000 individuals from diverse, at-risk populations across the metabolic health spectrum, demonstrating reproducible diagnostic performance
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Glucose metabolism and Radiodensity of Abdominal Adipose Tissue: A 5-year longitudinal study in a large PET cohort medRxiv. Endocrinol. Pub Date : 2024-01-22 Kyoungjune Pak, Severi Santavirta, Seunghyeon Shin, Hyun Yeol Nam, Sven De Maeyer, Lauri Nummenmaa
Objective: 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) allows the noninvasive assessment of glucose metabolism and radiodensity of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). Research design and methods: We retrospectively analyzed data from 435 healthy males (mean 42.8 years) who underwent health check-up program twice at baseline and 5-year
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Association of “Metabolic Dysfunction-Associated Steatotic Pancreas Disease” (MASPD) with Insulin Resistance medRxiv. Endocrinol. Pub Date : 2024-01-15 Luís Jesuino de Oliveira Andrade, Gabriela Correia Matos de Oliveira, Alcina Maria Vinhaes Bittencourt, Guilherme Peixoto Nascimento, Gustavo Magno Baptista, Catharina Peixoto Silva, Luís Matos de Oliveira
Introduction “Metabolic Dysfunction-Associated Steatotic Pancreas Disease” (MASPD) is not yet a term or condition described in the medical literature. The MASPD is a relatively new and emerging condition that has garnered significant attention in the field of metabolic disorders.
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A cross-sectional questionnaire study: impaired awareness of hypoglycaemia remains prevalent in adults with type 1 diabetes and is associated with the risk of severe hypoglycaemia medRxiv. Endocrinol. Pub Date : 2024-01-12 F. Baxter, N. Baillie, A. Dover, R.H. Stimson, F. Gibb, S. Forbes
Objective Impaired awareness of hypoglycaemia (IAH) is a risk factor for severe hypoglycaemia (SH) in type 1 diabetes (T1D). Much of the IAH prevalence data comes from older studies where participants did not have the benefit of the latest insulins and technologies. This study surveyed the prevalence of IAH and SH in a tertiary adult clinic population and investigated the associated factors.
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GLP-1 enhances beta-cell response to protein ingestion independent of glycemia and bariatric surgery amplifies it medRxiv. Endocrinol. Pub Date : 2024-01-11 Maria Rayas, Amalia Gastaldelli, Henri Honka, Samantha Pezzica, Fabrizia Carli, Richard Peterson, Ralph DeFronzo, Marzieh Salehi
Background The glycemic-independent actions of glucagon-like peptide 1 (GLP-1) in the prandial state in humans are largely unknown. Protein ingestion stimulates beta-cell secretion without changing plasma glucose concentration. We examined the contribution of endogenous GLP-1 to glucose metabolism and beta-cell response to protein ingestion under basal glucose concentrations, and whether these responses
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Efficacy of Different Treatment Approaches (Insulin and Metformin) in Women with Gestational Diabetes Mellitus (GDM) medRxiv. Endocrinol. Pub Date : 2024-01-11 Natalia Asatiani, Ramaz Kurashvili, Elena Shelestova
Background and Purpose The pharmacotherapy options in patients with GDM, are insulin or oral antihyperglycemic agents. Insulin is the preferred medication for treating hyperglycemia, but in recent years, metformin has been increasingly used in the treatment of GDM.
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Insulin resistance assessed by short insulin tolerance test and its association with obesity and insulin resistance-related parameters in humans: A randomized trial medRxiv. Endocrinol. Pub Date : 2024-01-13 Akiko Hayashishita, Taku Watanabe, Naoko Suzuki, Toshitaka Nakaya, Ayako Sugimoto, Isao Yokota, Hiroshi Ohira, Masaharu Nishimura, Ichizo Tsujino
The aim of this study was to examine the association of insulin resistance (evaluated by the short insulin tolerance test [SITT]) with parameters related to obesity and insulin resistance. We prospectively recruited controls and patients with type 2 diabetes mellitus (T2DM), subjected them to the SITT, and calculated the K indices of the intravenous insulin tolerance test (KITT(iv)) and the subcutaneous
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Mendelian randomization study on the association between cheese intake and diabetes medRxiv. Endocrinol. Pub Date : 2024-01-13 Si-Qi Yang, Yu Xu, Yan-Bing Zhang, Wei-Xing Wang
Objective To explore whether there is a causal relationship between cheese intake and diabetes through Mendel randomization (MR).
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Do People Reduce Attempts At Lifestyle Change After Initiating Weight Loss Medication? A Review Of Trial Evidence medRxiv. Endocrinol. Pub Date : 2024-01-13 Megan Macfarlane, David Cooper, Alison Avenell
Anti-obesity medications (AOMs) are used with lifestyle change support for weight management for adults with obesity. We investigated whether initiation of AOMs appeared to reduce attempted lifestyle changes. We searched for orlistat, liraglutide, semaglutide, and low-fat reducing diet (LFRD) trials in a trial register, Medline, Embase and systematic reviews from 1990 to June 2023. Weight changes in
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Effects of a diverse prebiotic fibre supplement on HbA1c, insulin sensitivity, and inflammatory biomarkers in pre-diabetes: a randomised placebo-controlled clinical trial medRxiv. Endocrinol. Pub Date : 2024-01-11 Caitlin V Hall, John L Twelves, Manish Saxena, Leonardo Scapozza, Thomas Gurry
Prebiotic fibre represents a promising and efficacious treatment to manage pre-diabetes, acting via complementary pathways involving the gut microbiome and viscosity-related properties. In this study, we evaluated the effect of using a diverse prebiotic fibre supplement on glycaemic, lipid, and inflammatory biomarkers in patients with pre-diabetes. Sixty-six patients diagnosed with pre-diabetes (yet
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Development of Portable Electronic Health Record Based Algorithms to Identify Individuals with Diabetic Retinopathy medRxiv. Endocrinol. Pub Date : 2024-01-05 Joseph H. Breeyear, Sabrina L. Mitchell, Cari L. Nealon, Jacklyn N. Hellwege, Brian Charest, Anjali Khakharia, Christopher W. Halladay, Janine Yang, Gustavo A. Garriga, Otis D. Wilson, Til B. Basnet, Adriana M. Hung, Peter D. Reaven, James B Meigs, Mary K Rhee, Yang Sun, Mary G. Lynch, Lucia Sobrin, Milam A. Brantley, Yan V. Sun, Peter W. Wilson, Sudha K. Iyengar, Neal S. Peachey, Lawrence S. Phillips
Objectives To develop, validate and implement algorithms to identify diabetic retinopathy (DR) cases and controls from electronic health care records (EHR)s. Methods: We developed and validated EHR-based algorithms to identify DR cases and individuals with type I or II diabetes without DR (controls) in three independent EHR systems: Vanderbilt University Medical Center Synthetic Derivative (VUMC),
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The impact of major depressive disorder on glycaemic control in type 2 diabetes: a longitudinal cohort study using UK Biobank primary care records medRxiv. Endocrinol. Pub Date : 2024-01-05 Alexandra C Gillett, Saskia P Hagenaars, Dale Handley, Francesco Casanova, Katherine G Young, Harry Green, Cathryn M Lewis, Jess Tyrrell
Background This study evaluates longitudinal associations between glycaemic control (mean and within-patient variability of glycated haemaglobin (HbA1c) levels) in individuals with type 2 diabetes (T2D) and major depressive disorder (MDD), focusing on the timings of these diagnoses.
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Vitamin D and Prebiotics for Intestinal Health in Cystic Fibrosis: Rationale and design for a randomized, placebo-controlled, double-blind, 2 × 2 trial of administration of prebiotics and cholecalciferol (vitamin D3) (Pre-D Trial) in adults with cystic fibrosis medRxiv. Endocrinol. Pub Date : 2024-01-05 Alisa K. Sivapiromrat, Pichatorn Suppakitjanusant, Yanling Wang, Jose Binongo, William R. Hunt, Andrew Gewirtz, Jessica A. Alvarez, Chengcheng Hu, Samuel Weinstein, Ishaan Jathal, Thomas R. Ziegler, Vin Tangpricha
Individuals with cystic fibrosis (CF) have dysfunctional intestinal microbiota and increased gastrointestinal (GI) inflammation also known as GI dysbiosis. It is hypothesized that administration of high-dose cholecalciferol (vitamin D3) together with a prebiotic (inulin) will be effective, and possibly additive or synergistic, in reducing CF-related GI dysbiosis and improving intestinal functions.
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Machine learning across multiple imaging and biomarker modalities in the UK Biobank improves genetic discovery for liver fat accumulation medRxiv. Endocrinol. Pub Date : 2024-01-07 Hari Somineni, Sumit Mukherjee, David Amar, Jingwen Pei, Karl Guo, David Light, Kaitlin Flynn, insitro Research Team, Chris Probert, Thomas Soare, Santhosh Satapati, Daphne Koller, David J. Lloyd, Colm O’Dushlaine
Metabolic dysfunction-associated steatotic liver disease (MASLD), liver with more than 5.5% fat content, is a leading risk factor for chronic liver disease with an estimated worldwide prevalence of 30%. Though MASLD is widely recognized to be polygenic, genetic discovery has been lacking primarily due to the need for accurate and scalable phenotyping, which proves to be costly, time-intensive and variable
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Safety and effectiveness of SGLT2-inhibitors in people with type 2 diabetes over 70: UK population-based study using an Instrumental Variable approach medRxiv. Endocrinol. Pub Date : 2024-01-04 Laura Maria Güdemann, Katie G. Young, Nicholas J. M. Thomas, Rhian Hopkins, Robert Challen, Angus G. Jones, Andrew T. Hattersley, Ewan R Pearson, Beverley M. Shields, Jack Bowden, John M. Dennis, Andrew P. McGovern, the Mastermind consortium
Objective Older adults are underrepresented in trials, meaning the benefits and risks of glucose lowering agents in this age group are unclear. We applied causal analysis to assess the safety and effectiveness of SGLT2-inhibitors in people with type 2 diabetes (T2D) over 70.