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Zebrafish ApoB-Containing Lipoprotein Metabolism: A Closer Look Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-03-14 Tabea Moll, Steven A. Farber
Zebrafish have become a powerful model of mammalian lipoprotein metabolism and lipid cell biology. Most key proteins involved in lipid metabolism, including cholesteryl ester transfer protein, are conserved in zebrafish. Consequently, zebrafish exhibit a human-like lipoprotein profile. Zebrafish with mutations in genes linked to human metabolic diseases often mimic the human phenotype. Zebrafish larvae
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Identification of New Markers of Angiogenic Sprouting Using Transcriptomics: New Role for RND3 Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-03-14 Colette A. Abbey, Camille L. Duran, Zhishi Chen, Yanping Chen, Sukanya Roy, Ashley Coffell, Timothy M. Sveeggen, Sanjukta Chakraborty, Gregg B. Wells, Jiang Chang, Kayla J. Bayless
BACKGROUND:New blood vessel formation requires endothelial cells to transition from a quiescent to an invasive phenotype. Transcriptional changes are vital for this switch, but a comprehensive genome-wide approach focused exclusively on endothelial cell sprout initiation has not been reported.METHODS:Using a model of human endothelial cell sprout initiation, we developed a protocol to physically separate
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Prior Exposure to Experimental Preeclampsia Increases Atherosclerotic Plaque Inflammation in Atherogenic Mice Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-03-07 Lauren A. Biwer, Joshua J. Man, Nicholas D. Camarda, Brigett V. Carvajal, S. Ananth Karumanchi, Iris Z. Jaffe
BACKGROUND:Women with a history of preeclampsia have evidence of premature atherosclerosis and increased risk of myocardial infarction and stroke compared with women who had a normotensive pregnancy. Whether this is due to common risk factors or a direct impact of prior preeclampsia exposure has never been tested in a mouse atherosclerosis model.METHODS:Pregnant LDLR-KO (low-density lipoprotein receptor
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High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-22 Alexander C. Bashore, Hanying Yan, Chenyi Xue, Lucie Y. Zhu, Eunyoung Kim, Thomas Mawson, Johana Coronel, Allen Chung, Nadja Sachs, Sebastian Ho, Leila S. Ross, Michael Kissner, Emmanuelle Passegué, Robert C. Bauer, Lars Maegdefessel, Mingyao Li, Muredach P. Reilly
BACKGROUND:Atherosclerotic plaques are complex tissues composed of a heterogeneous mixture of cells. However, our understanding of the comprehensive transcriptional and phenotypic landscape of the cells within these lesions is limited.METHODS:To characterize the landscape of human carotid atherosclerosis in greater detail, we combined cellular indexing of transcriptomes and epitopes by sequencing and
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Inhibition of IL-1 Ameliorates Cardiac Dysfunction and Arrhythmias in a Murine Model of Kawasaki Disease Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-22 Thassio Mesquita, Yen-Nien Lin, Shuang Chen, Youngho Lee, Rodrigo Miguel-dos-Santos, Asli E. Atici, Michael C. Fishbein, Magali Noval Rivas, Moshe Arditi, Eugenio Cingolani
BACKGROUND:Kawasaki disease (KD) is an acute febrile illness and systemic vasculitis often associated with cardiac sequelae, including arrhythmias. Abundant evidence indicates a central role for IL (interleukin)-1 and TNFα (tumor necrosis factor-alpha) signaling in the formation of arterial lesions in KD. We aimed to investigate the mechanisms underlying the development of electrophysiological abnormalities
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Use of Genomics to Develop Novel Therapeutics and Personalize Hypertension Therapy Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-22 Emma F. Magavern, Vikas Kapil, Manish Saxena, Ajay Gupta, Mark J. Caulfield
Hypertension is a prevalent public health problem, contributing to >10 million deaths annually. Though multiple therapeutics exist, many patients suffer from treatment-resistant hypertension or try several medications before achieving blood pressure control. Genomic advances offer mechanistic understanding of blood pressure variability, therapeutic targets, therapeutic response, and promise a stratified
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Differences in Cardiometabolic Proteins in Pregnancy Prioritize Relevant Targets of Preeclampsia Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-22 Kathryn J. Lindley, Andrew Perry, Marni Jacobs, Lauren Petty, Kaushik Amancherla, Shilin Zhao, Claire Barker, Victor G. Davila-Roman, Sadiya S. Khan, Sarah S. Osmundson, Kahraman Tanriverdi, Jane E. Freedman, Jennifer Below, Ravi V. Shah, Louise C. Laurent
Background:Preeclampsia is a hypertensive disorder of pregnancy characterized by widespread vascular inflammation. It occurs frequently in pregnancy, often without known risk factors, and has high rates of maternal and fetal morbidity and mortality. Identification of biomarkers that predict preeclampsia and its cardiovascular sequelae before clinical onset, or even before pregnancy, is a critical unmet
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Calcium Signaling in Airway Epithelial Cells: Current Understanding and Implications for Inflammatory Airway Disease Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-22 Amit Jairaman, Murali Prakriya
Airway epithelial cells play an indispensable role in protecting the lung from inhaled pathogens and allergens by releasing an array of mediators that orchestrate inflammatory and immune responses when confronted with harmful environmental triggers. While this process is undoubtedly important for containing the effects of various harmful insults, dysregulation of the inflammatory response can cause
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ANGPTL3 Downregulation Increases Intracellular Lipids by Reducing Energy Utilization Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-22 Grazia Pennisi, Samantha Maurotti, Ester Ciociola, Oveis Jamialahmadi, Giorgio Bertolazzi, Angela Mirarchi, Per-Olof Bergh, Francesca Scionti, Rosellina M. Mancina, Rocco Spagnuolo, Claudio Tripodo, Jan Boren, Salvatore Petta, Stefano Romeo
Background:ANGPTL3 (angiopoietin-like protein 3) is a circulating protein with a key role in maintaining lipoprotein homeostasis. A monoclonal antibody against ANGPTL3 is an approved and well-tolerated treatment to reduce lipoproteins in familial hypercholesterolemia homozygotes. However, the reduction of hepatic ANGPTL3 synthesis using an antisense oligonucleotide unexpectedly resulted in a dose-dependent
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Reduced Monocyte and Neutrophil Infiltration and Activation by P-Selectin/CD62P Inhibition Enhances Thrombus Resolution Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-22 Julia B. Kral-Pointner, Patrick Haider, Petra L. Szabo, Manuel Salzmann, Mira Brekalo, Karl H. Schneider, Waltraud C. Schrottmaier, Christoph Kaun, Sonja Bleichert, Attila Kiss, Romana Sickha, Christian Hengstenberg, Kurt Huber, Christine Brostjan, Helga Bergmeister, Alice Assinger, Bruno K. Podesser, Johann Wojta, Philipp Hohensinner
Background:Venous thromboembolism is a major health problem. After thrombus formation, its resolution is essential to re-establish blood flow, which is crucially mediated by infiltrating neutrophils and monocytes in concert with activated platelets and endothelial cells. Thus, we aimed to modulate leukocyte function during thrombus resolution post-thrombus formation by blocking P-selectin/CD62P-mediated
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Correction to: Long Noncoding RNA Gpr137b-ps Promotes Advanced Atherosclerosis via the Regulation of Autophagy in Macrophages Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-21
The authors of the following Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) article have requested a clarification: Qu et al. Long Noncoding RNA Gpr137b-ps Promotes Advanced Atherosclerosis via the Regulation of Autophagy in Macrophages. Arterioscler Thromb Vasc Biol. 2023;43:e468–e489. https://www.ahajournals.org/doi/10.1161/ATVBAHA.123.319037. After publication, questions were raised about
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Valvular Prostaglandins Are Elevated in Severe Human Aortic Valve Stenosis Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-15 Lucien G.J. Cayer, Arun Surendran, Tobias Karakach, Harold M. Aukema, Amir Ravandi
BACKGROUND:Aortic valve stenosis (AVS) is the most common valvular disease in the developed world. AVS involves the progressive fibrocalcific remodeling of the aortic valve (AV), which impairs function and can ultimately lead to heart failure. Due to gaps in our understanding of the underlying mechanisms of AVS, there are no pharmacological treatments or dietary interventions known to slow AVS progression
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PAR4 Antagonism in Patients With Coronary Artery Disease Receiving Antiplatelet Therapies Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-15 Jennifer Nash, Mohammed N. Meah, Beth Whittington, Samuel Debono, Jennifer Raftis, Mark R. Miller, Andrew Sorbie, Nicholas L. Mills, Josselin Nespoux, Lorraine Bruce, Rodger Duffin, Neeraj Dhaun, Mairi Brittan, Longfei Chao, Samira Merali, Minji Kim, Zhaoqing Wang, Yue Zhang, Shiqiang Jin, Beqing Wang, Marc Kozinn, David E. Newby
BACKGROUND:BMS-986141 is a novel potent highly selective antagonist of PAR (protease-activated receptor) type 4. PAR4 antagonism has been demonstrated to reduce thrombus formation in isolation and in combination with factor Xa inhibition in high shear conditions in healthy people. We sought to determine whether PAR4 antagonism had additive antithrombotic effects in patients with coronary artery disease
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Single-Cell Transcriptome Reveals Potential Mechanisms for Coronary Artery Lesions in Kawasaki Disease Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-15 Yeshi Chen, Minna Yang, Mingming Zhang, Hongmao Wang, Yang Zheng, Rui Sun, Xiaohui Li
BACKGROUND:Coronary artery lesions (CALs) are the most common and major complication of Kawasaki disease (KD) in developed countries. However, the underlying immunologic mechanisms of CAL development in KD remain unclear.METHODS:Here, we conducted single-cell transcriptome analyses of 212 210 peripheral blood mononuclear cells collected from a cross-sectional cohort of 16 children, including 4 patients
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Microvascular Network Remodeling in the Ischemic Mouse Brain Defined by Light Sheet Microscopy Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-15 Nina Hagemann, Yachao Qi, Ayan Mohamud Yusuf, AnRan Li, Anthony Squire, Tobias Tertel, Bernd Giebel, Peter Ludewig, Philippa Spangenberg, Jianxu Chen, Axel Mosig, Matthias Gunzer, Dirk M. Hermann
BACKGROUND:Until now, the analysis of microvascular networks in the reperfused ischemic brain has been limited due to tissue transparency challenges.METHODS:Using light sheet microscopy, we assessed microvascular network remodeling from 3 hours to 56 days post-ischemia in 2 mouse models of transient middle cerebral artery occlusion lasting 20 or 40 minutes, resulting in mild ischemic brain injury or
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Angiogenesis in Chronic Thromboembolic Pulmonary Hypertension: A Janus-Faced Player? Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-08 Lynn Willems, Kondababu Kurakula, Janne Verhaegen, Frederikus A. Klok, Marion Delcroix, Marie-José Goumans, Rozenn Quarck
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare form of pulmonary hypertension characterized by the presence of organized thrombi that obstruct pulmonary arteries, ultimately leading to right heart failure and death. Among others, impaired angiogenesis and inflammatory thrombosis have been shown to contribute to the progression of CTEPH. In this review, we summarize the 2-faced nature
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Plasma S1P Orchestrates the Reverse Transendothelial Migration of Aortic Intimal Myeloid Cells in Mice Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-08 Chanele K. Polenz, Corey A. Scipione, Sharon J. Hyduk, Marwan G. Althagafi, Hisham M. Ibrahim, Myron I. Cybulsky
BACKGROUND:Myeloid cells (MCs) reside in the aortic intima at regions predisposed to atherosclerosis. Systemic inflammation triggers reverse transendothelial migration (RTM) of intimal MCs into the arterial blood, which orchestrates a protective immune response that clears intracellular pathogens from the arterial intima. Molecular pathways that regulate RTM remain poorly understood. S1P (sphingosine-1-phosphate)
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Secreted Protein Profiling of Human Aortic Smooth Muscle Cells Identifies Vascular Disease Associations Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-08 Rédouane Aherrahrou, Ferheen Baig, Konstantinos Theofilatos, Dillon Lue, Alicia Beele, Tiit Örd, Minna U. Kaikkonen, Zouhair Aherrahrou, Qi Cheng, Saikat Ghosh, Santosh Karnewar, Vaishnavi Karnewar, Aloke Finn, Gary K. Owens, Michael Joner, Manuel Mayr, Mete Civelek
BACKGROUND:Smooth muscle cells (SMCs), which make up the medial layer of arteries, are key cell types involved in cardiovascular disease, the leading cause of mortality and morbidity worldwide. In response to microenvironment alterations, SMCs dedifferentiate from a contractile to a synthetic phenotype characterized by an increased proliferation, migration, production of ECM (extracellular matrix)
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p53 Acetylation Exerts Critical Roles in Pressure Overload–Induced Coronary Microvascular Dysfunction and Heart Failure in Mice Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-08 Xiaochen He, Aubrey C. Cantrell, Quinesha A. Williams, Wei Gu, Yingjie Chen, Jian-Xiong Chen, Heng Zeng
BACKGROUND:Coronary microvascular dysfunction (CMD) has been shown to contribute to cardiac hypertrophy and heart failure (HF) with preserved ejection fraction. At this point, there are no proven treatments for CMD.METHODS:We have shown that histone acetylation may play a critical role in the regulation of CMD. By using a mouse model that replaces lysine with arginine at residues K98, K117, K161, and
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Predicting Lipid-Rich Plaque Progression in Coronary Arteries Using Multimodal Imaging and Wall Shear Stress Signatures Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-08 Giuseppe De Nisco, Eline M.J. Hartman, Elena Torta, Joost Daemen, Claudio Chiastra, Diego Gallo, Umberto Morbiducci, Jolanda J. Wentzel
BACKGROUND:Plaque composition and wall shear stress (WSS) magnitude act as well-established players in coronary plaque progression. However, WSS magnitude per se does not completely capture the mechanical stimulus to which the endothelium is subjected, since endothelial cells experience changes in the WSS spatiotemporal configuration on the luminal surface. This study explores WSS profile and lipid
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Regulation of YAP Promotor Accessibility in Endothelial Mechanotransduction Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-02-01 Aarren J. Mannion, Honglei Zhao, Yuanyuan Zhang, Ylva von Wright, Otto Bergman, Joy Roy, Pipsa Saharinen, Lars Holmgren
BACKGROUND:Endothelial cells are constantly exposed to mechanical forces in the form of fluid shear stress, extracellular stiffness, and cyclic strain. The mechanoresponsive activity of YAP (Yes-associated protein) and its role in vascular development are well described; however, whether changes to transcription or epigenetic regulation of YAP are involved in these processes remains unanswered. Furthermore
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Nonpreferential but Detrimental Accumulation of Macrophages With Clonal Hematopoiesis-Driver Mutations in Cardiovascular Tissues—Brief Report Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-25 Tsai-Sang Dederichs, Assel Yerdenova, Hauke Horstmann, Tamara Antonela Vico, Simone Nübling, Rémi Peyronnet, Dietmar Pfeifer, Constantin von zur Muehlen, Timo Heidt, Dennis Wolf, Martin Czerny, Dirk Westermann, Ingo Hilgendorf
BACKGROUND:Clonal hematopoiesis of indeterminate potential (CHIP) is an acquired genetic risk factor for both leukemia and cardiovascular disease. It results in proinflammatory myeloid cells in the bone marrow and blood; however, how these cells behave in the cardiovascular tissue remains unclear. Our study aimed at investigating whether CHIP-mutated macrophages accumulate preferentially in cardiovascular
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Single-Cell RNA-Seq Reveals Coronary Heterogeneity and Identifies CD133+TRPV4high Endothelial Subpopulation in Regulating Flow-Induced Vascular Tone in Mice Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-25 Aiqin Mao, Ka Zhang, Hao Kan, Mengru Gao, Zhiwei Wang, Tingting Zhou, Jing Shao, Dongxu He
BACKGROUND:Single-cell RNA-Seq analysis can determine the heterogeneity of cells between different tissues at a single-cell level. Coronary artery endothelial cells (ECs) are important to coronary blood flow. However, little is known about the heterogeneity of coronary artery ECs, and cellular identity responses to flow. Identifying endothelial subpopulations will contribute to the precise localization
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Diacylglycerols and Lysophosphatidic Acid, Enriched on Lipoprotein(a), Contribute to Monocyte Inflammation Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-25 Kim E. Dzobo, Arjen Cupido, Barend M. Mol, Lotte C.A. Stiekema, Miranda Versloot, Maaike Winkelmeijer, Jorge Peter, Anne-Marije Pennekamp, Stefan Havik, Frédéric M. Vaz, Michel van Weeghel, Koen H.M. Prange, Johannes H.M. Levels, Menno P.J. de Winther, Sotirios Tsimikas, Albert K. Groen, Erik S.G. Stroes, Dominique P.V. de Kleijn, Jeffrey Kroon
BACKGROUND: Oxidized phospholipids play a key role in the atherogenic potential of lipoprotein(a; Lp[a]); however, Lp(a) is a complex particle that warrants research into additional proinflammatory mediators. We hypothesized that additional Lp(a)-associated lipids contribute to the atherogenicity of Lp(a). METHODS: Untargeted lipidomics was performed on plasma and isolated lipoprotein fractions. The
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New Mechanistic Insight Into Biased Signaling of Proteinase-Activated Receptor 1 Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-25 Katsuya Hirano
PAR1 (proteinase-activated receptor 1) is a G protein-coupled receptor that was originally identified as a signaling receptor that mediates the cellular effects of thrombin. A variety of proteinases, including those involved in coagulation and fibrinolysis, which are relevant to vascular physiology and pathophysiology, are now known to serve as agonists of PAR1.1,2 Currently, 4 subtypes of PAR, PAR1≈PAR4
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Profibrotic VEGFR3-Dependent Lymphatic Vessel Growth in Autoimmune Valvular Carditis Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-25 Victoria Osinski, Amritha Yellamilli, Maria M. Firulyova, Michael J. Zhang, Alyssa L. Peck, Jennifer L. Auger, Jessica L. Faragher, Aubyn Marath, Rochus K. Voeller, Timothy D. O’Connell, Konstantin Zaitsev, Bryce A. Binstadt
BACKGROUND:Rheumatic heart disease is the major cause of valvular heart disease in developing nations. Endothelial cells (ECs) are considered crucial contributors to rheumatic heart disease, but greater insight into their roles in disease progression is needed.METHODS:We used a Cdh5-driven EC lineage-tracing approach to identify and track ECs in the K/B.g7 model of autoimmune valvular carditis. Single-cell
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Prostanoids in Cardiac and Vascular Remodeling Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-25 Emanuela Ricciotti, Philip G. Haines, William Chai, Garret A. FitzGerald
Prostanoids are biologically active lipids generated from arachidonic acid by the action of the COX (cyclooxygenase) isozymes. NSAIDs, which reduce the biosynthesis of prostanoids by inhibiting COX activity, are effective anti-inflammatory, antipyretic, and analgesic drugs. However, their use is limited by cardiovascular adverse effects, including myocardial infarction, stroke, hypertension, and heart
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Food Intake Suppresses ApoB Secretion and Fractional Catabolic Rates in Humans Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-24 Chunyu Zheng, Allison B. Andraski, Christina Khoo, Jeremy D. Furtado, Frank M. Sacks
BACKGROUND: Humans spend much of the day in the postprandial state. However, most research and clinical guidelines on plasma lipids pertain to blood drawn after a 12-hour fast. We aimed to study the metabolic differences of apoB lipoproteins between the fasting and postprandial states. METHODS: We investigated plasma apoB metabolism using stable isotope tracers in 12 adult volunteers under fasting
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Genome-Wide Genetic Associations Prioritize Evaluation of Causal Mechanisms of Atherosclerotic Disease Risk Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-24 Thomas Quertermous, Daniel Yuhang Li, Chad S. Weldy, Markus Ramste, Disha Sharma, João P. Monteiro, Wenduo Gu, Matthew D. Worssam, Brian T. Palmisano, Chong Y. Park, Paul Cheng
OBJECTIVE: The goal of this review is to discuss the implementation of genome-wide association studies to identify causal mechanisms of vascular disease risk. APPROACH AND RESULTS: The history of genome-wide association studies is described, the use of imputation and the creation of consortia to conduct meta-analyses with sufficient power to arrive at consistent associated loci for vascular disease
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Dietary Vitamin K 1 Intake and Incident Aortic Valve Stenosis Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-24 Carl J. Schultz, Frederik Dalgaard, Jamie W. Bellinge, Kevin Murray, Marc Sim, Emma Connolly, Lauren C. Blekkenhorst, Catherine P. Bondonno, Joshua R. Lewis, Gunnar H. Gislason, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson, Nicola P. Bondonno
BACKGROUND: Leaflet calcification contributes to the development and progression of aortic valve stenosis. Vitamin K activates inhibitors of vascular calcification and may modulate inflammation and skeletal bone loss. Therefore, we aimed to determine whether higher dietary intakes of vitamin K 1 are associated with a lower incidence of aortic stenosis. METHODS: In the Danish Diet, Cancer and Health
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Exosomes From IgE-Stimulated Mast Cells Aggravate Asthma-Mediated Atherosclerosis Through circRNA CDR1as-Mediated Endothelial Cell Dysfunction in Mice Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-18 Hongqin Yang, Junye Chen, Siyang Liu, Yunfei Xue, Zhiwei Li, Tao Wang, Liqun Jiao, Qi An, Bao Liu, Jing Wang, Hongmei Zhao
BACKGROUND:IgE has been known for mediating endothelial cell dysfunction and mast cell (MC) activation to fuel asthma-aggravated high-fat diet–induced atherosclerosis. However, it remains unclear for the mechanism of asthma-mediated atherosclerosis, especially the potential involvement of IgE in the exacerbation of asthma-mediated atherosclerosis with a standard laboratory diet, and the cross talk
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Clot or Not? Reviewing the Reciprocal Regulation Between Lipids and Blood Clotting Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-18 Ziyu Zhang, Maya Rodriguez, Ze Zheng
Both hyperlipidemia and thrombosis contribute to the risks of atherosclerotic cardiovascular diseases, which are the leading cause of death and reduced quality of life in survivors worldwide. The accumulation of lipid-rich plaques on arterial walls eventually leads to the rupture or erosion of vulnerable lesions, triggering excessive blood clotting and leading to adverse thrombotic events. Lipoproteins
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Platelets in Hemostasis, Thrombosis, and Inflammation After Major Trauma Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-18 Paul Vulliamy, Paul C. Armstrong
Trauma currently accounts for 10% of the total global burden of disease and over 5 million deaths per year, making it a leading cause of morbidity and mortality worldwide. Although recent advances in early resuscitation have improved early survival from critical injury, the mortality rate in patients with major hemorrhage approaches 50% even in mature trauma systems. A major determinant of clinical
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Reflections on Belonging: ATVB Membership Committee Perspective Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-18 Shayan Mohammadmoradi, Jeffrey J. Hsu, Anberitha T. Matthews
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FSH Is Responsible for Androgen Deprivation Therapy–Associated Atherosclerosis in Mice by Exaggerating Endothelial Inflammation and Monocyte Adhesion Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-11 Qiang Wang, Jingli Han, Zhenhui Liang, Xueyu Geng, Yiqing Du, Jing Zhou, Weijuan Yao, Tao Xu
BACKGROUND: Androgen deprivation therapy (ADT) is the mainstay treatment for advanced prostate cancer. But ADTs with orchiectomy and gonadotropin-releasing hormone (GnRH) agonist are associated with increased risk of cardiovascular diseases, which appears less significant with GnRH antagonist. The difference of follicle-stimulating hormone (FSH) in ADT modalities is hypothesized to be responsible for
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Endoplasmic Reticulum Protein 72 Regulates Integrin Mac-1 Activity to Influence Neutrophil Recruitment Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-11 Joyce Chiu
BACKGROUND:Integrins mediate the adhesion, crawling, and migration of neutrophils during vascular inflammation. Thiol exchange is important in the regulation of integrin functions. ERp72 (endoplasmic reticulum–resident protein 72) is a member of the thiol isomerase family responsible for the catalysis of disulfide rearrangement. However, the role of ERp72 in the regulation of Mac-1 (integrin αMβ2)
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Phosphate in Cardiovascular Disease: From New Insights Into Molecular Mechanisms to Clinical Implications Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-11 Mandy E. Turner, Laurent Beck, Kathleen M. Hill Gallant, Yabing Chen, Orson W. Moe, Makoto Kuro-o, Sharon M. Moe, Elena Aikawa
Hyperphosphatemia is a common feature in patients with impaired kidney function and is associated with increased risk of cardiovascular disease. This phenomenon extends to the general population, whereby elevations of serum phosphate within the normal range increase risk; however, the mechanism by which this occurs is multifaceted, and many aspects are poorly understood. Less than 1% of total body
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Bioengineering Cell Therapy for Treatment of Peripheral Artery Disease Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-04 Ngan F. Huang, Brett Stern, Beu P. Oropeza, Tatiana S. Zaitseva, Michael V. Paukshto, Janet Zoldan
Peripheral artery disease is an atherosclerotic disease associated with limb ischemia that necessitates limb amputation in severe cases. Cell therapies comprised of adult mononuclear or stromal cells have been clinically tested and show moderate benefits. Bioengineering strategies can be applied to modify cell behavior and function in a controllable fashion. Using mechanically tunable or spatially
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Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2024-01-04 Indranil Biswas, Hemant Giri, Sumith R. Panicker, Alireza R. Rezaie
BACKGROUND:Cleavage of the extracellular domain of PAR1 (protease-activated receptor 1) by thrombin at Arg41 and by APC (activated protein C) at Arg46 initiates paradoxical cytopathic and cytoprotective signaling in endothelial cells. In the latter case, the ligand-dependent coreceptor signaling by EPCR (endothelial protein C receptor) is required for the protective PAR1 signaling by APC. Here, we
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Changes in Gut Microbiota After Statin Administration: A New Candidate Mechanism for Statin-Associated New-Onset Type 2 Diabetes Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-28 Ichiro Sakuma
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PI3KCIIα-Dependent Autophagy Program Protects From Endothelial Dysfunction and Atherosclerosis in Response to Low Shear Stress in Mice Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-28 Mouin Nasr, Alexis Fay, Adrien Lupieri, Nicole Malet, Anne Darmon, Rana Zahreddine, Audrey Swiader, Amandine Wahart, Julien Viaud, Anne Nègre-Salvayre, Emilio Hirsch, Daniel Monteyne, David Perez-Morgà, Nicolas Dupont, Patrice Codogno, Damien Ramel, Etienne Morel, Muriel Laffargue, Stephanie Gayral
BACKGROUND:The ability to respond to mechanical forces is a basic requirement for maintaining endothelial cell (ECs) homeostasis, which is continuously subjected to low shear stress (LSS) and high shear stress (HSS). In arteries, LSS and HSS have a differential impact on EC autophagy processes. However, it is still unclear whether LSS and HSS differently tune unique autophagic machinery or trigger
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Imaging the Retinal Vascular Mural Cells In Vivo: Elucidating the Timeline of Their Loss in Diabetic Retinopathy Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-28 Bonnie B. Huang, Hisashi Fukuyama, Stephen A. Burns, Amani A. Fawzi
BACKGROUND: Vascular mural cells (VMCs) are integral components of the retinal vasculature with critical homeostatic functions such as maintaining the inner blood-retinal barrier and vascular tone, as well as supporting the endothelial cells. Histopathologic donor eye studies have shown widespread loss of pericytes and smooth muscle cells, the 2 main VMC types, suggesting these cells are critical to
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Comprehensive Integration of Multiple Single-Cell Transcriptomic Datasets Defines Distinct Cell Populations and Their Phenotypic Changes in Murine Atherosclerosis Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-28 Disha Sharma, Matthew DeForest Worssam, Albert J. Pedroza, Alex R. Dalal, Haizea Alemany, Hyun-Jung Kim, Ramendra Kundu, Michael Fischbein, Paul Cheng, Robert Wirka, Thomas Quertermous
Background: The application of single-cell transcriptomic (single-cell RNA sequencing) analysis to the study of atherosclerosis has provided unique insights into the molecular and genetic mechanisms that mediate disease risk and pathophysiology. However, nonstandardized methodologies and relatively high costs associated with the technique have limited the size and replication of existing data sets
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A Century of Milestones and Breakthroughs Related to Low- and High-Density Lipoproteins Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-27 Mary G. Sorci-Thomas, Robert A. Hegele, Alan T. Remaley
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Noncoding RNAs in the Vasculature: Basic Mechanisms and Therapeutic Perspectives Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-27 Lars Maegdefessel, Reinier A. Boon, Stefanie Dimmeler
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Requirement of Site-Specific Tyrosine Phosphorylation of Cortactin in Retinal Neovascularization and Vascular Leakage Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-21 Raj Kumar, Klemens Rottner, Gadiparthi N. Rao
BACKGROUND: Retinal neovascularization is a major cause of vision impairment. Therefore, the purpose of this study is to investigate the mechanisms by which hypoxia triggers the development of abnormal and leaky blood vessels. METHODS: A variety of cellular and molecular approaches as well as tissue-specific knockout mice were used to investigate the role of Cttn (cortactin) in retinal neovascularization
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N-Acetyl Cysteine Prevents Arterial Thrombosis in a Dose-Dependent Manner In Vitro and in Mice Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-21 Christopher A. Bresette, Katrina J. Ashworth, Jorge Di Paola, David N. Ku
BACKGROUND: Platelet-rich thrombi occlude arteries causing fatal infarcts like heart attacks and strokes. Prevention of thrombi by current antiplatelet agents can cause major bleeding. Instead, we propose using N-acetyl cysteine (NAC) to act against the protein VWF (von Willebrand factor), and not platelets, to prevent arterial thrombi from forming. METHODS: NAC was assessed for its ability to prevent
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Whole-Blood Transcriptome Unveils Altered Immune Response in Acute Myocardial Infarction Patients With Aortic Valve Sclerosis Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-21 Luca Piacentini, Veronika A. Myasoedova, Mattia Chiesa, Chiara Vavassori, Donato Moschetta, Vincenza Valerio, Gloria Giovanetti, Ilaria Massaiu, Nicola Cosentino, Giancarlo Marenzi, Paolo Poggio, Gualtiero I. Colombo
Background: Aortic valve sclerosis (AVSc) presents similar pathogenetic mechanisms to coronary artery disease and is associated with short- and long-term mortality in patients with coronary artery disease. Evidence of AVSc-specific pathophysiological traits in acute myocardial infarction (AMI) is currently lacking. Thus, we aimed to identify a blood-based transcriptional signature that could differentiate
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New Dimension to Study on Platelet Bioenergetics Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-21 D. Dash
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Extent of Abdominal Aortic Calcification Is Associated With Incident Rapid Weight Loss Over 5 Years: PLSAW Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-14 Cassandra Smith, Marc Sim, Jack Dalla Via, Abadi K. Gebre, Kun Zhu, Wai H. Lim, Ryan Teh, Douglas P. Kiel, John T. Schousboe, Itamar Levinger, Stephan von Haehling, Richard Woodman, Andrew J.S. Coats, Richard L. Prince, Joshua R. Lewis
BACKGROUND: Abdominal aortic calcification (AAC)—a marker of vascular disease—is associated with disease in other vascular beds including gastrointestinal arteries. We investigated whether AAC is related to rapid weight loss over 5 years and whether rapid weight loss is associated with 9.5-year all-cause mortality in community-dwelling older women. METHODS: Lateral spine images from dual-energy x-ray
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ApoA-I Protects Pancreatic β-Cells From Cholesterol-Induced Mitochondrial Damage and Restores Their Ability to Secrete Insulin Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-14 Bikash Manandhar, Elvis Pandzic, Nandan Deshpande, Sing-Young Chen, Valerie Wasinger, Maaike Kockx, Elias Glaros, Kwok Leung Ong, Shane R. Thomas, Marc R. Wilkins, Renee M. Whan, Blake J. Cochran, Kerry-Anne Rye
Background: High cholesterol levels in pancreatic β-cells cause oxidative stress and decrease insulin secretion. β-cells can internalize apo (apolipoprotein) A-I, which increases insulin secretion. This study asks whether internalization of apoA-I improves β-cell insulin secretion by reducing oxidative stress. Methods: Ins-1E cells were cholesterol-loaded by incubation with cholesterol-methyl-β-cyclodextrin
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Using Genomics to Identify Novel Therapeutic Targets for Aortic Disease Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-14 Avanthi Raghavan, James P. Pirruccello, Patrick T. Ellinor, Mark E. Lindsay
Aortic disease, including dissection, aneurysm, and rupture, carries significant morbidity and mortality and is a notable cause of sudden cardiac death. Much of our knowledge regarding the genetic basis of aortic disease has relied on the study of individuals with Mendelian aortopathies and, until recently, the genetic determinants of population-level variance in aortic phenotypes remained unclear
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Prediction of Venous Thromboembolism in Diverse Populations Using Machine Learning and Structured Electronic Health Records Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-14 Robert Chen, Ben Omega Petrazzini, Waqas Malick, Robert Rosenson, Ron Do
BACKGROUND: Venous thromboembolism (VTE) is a major cause of morbidity and mortality worldwide. Current risk assessment tools, such as the Caprini and Padua scores and Wells criteria, have limitations in their applicability and accuracy. This study aimed to develop machine learning models using structured electronic health record data to predict diagnosis and 1-year risk of VTE. METHODS: We trained
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New Player in an Old Field? Ecto-F 1 -ATPase in Antidiabetic Actions of HDL in Pancreatic β-Cells Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-14 Chieko Mineo, Philip W. Shaul
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Is It Ever Wise to Edit Wild-Type Alleles? Engineered CRISPR Alleles Versus Millions of Years of Human Evolution Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-07 Darby W. Kozan, Steven A. Farber
The tremendous burden of lipid metabolism diseases, coupled with recent developments in human somatic gene editing, has motivated researchers to propose population-wide somatic gene editing of PCSK9 (proprotein convertase subtilisin/kexin type 9) within the livers of otherwise healthy humans. The best-characterized molecular function of PCSK9 is its ability to regulate plasma LDL (low-density lipoprotein)
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Platelet RNA Biomarker of Ticagrelor-Responsive Genes Is Associated With Platelet Function and Cardiovascular Events Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-07 Rachel A. Myers, Thomas L. Ortel, Alexander Waldrop, MacIntosh Cornwell, Jonathan D. Newman, Natalie K. Levy, Tessa J. Barrett, Kelly Ruggles, Marcin A. Sowa, Sandeep Dave, Geoffrey S. Ginsburg, Jeffrey S. Berger, Deepak Voora
Background: Identifying patients with the optimal risk:benefit for ticagrelor is challenging. The aim was to identify ticagrelor-responsive platelet transcripts as biomarkers of platelet function and cardiovascular risk. Methods: Healthy volunteers (n=58, discovery; n=49, validation) were exposed to 4 weeks of ticagrelor with platelet RNA data, platelet function, and self-reported bleeding measured
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Thrombomodulin Regulates PTEN/AKT Signaling Axis in Endothelial Cells Arterioscler. Thromb. Vasc. Biol. (IF 8.7) Pub Date : 2023-12-07 Hemant Giri, Indranil Biswas, Alireza R. Rezaie
Background: We recently demonstrated that deletion of thrombomodulin gene from endothelial cells results in upregulation of proinflammatory phenotype. In this study, we investigated the molecular basis for the altered phenotype in thrombomodulin-deficient (TM −/− ) cells. Methods: Different constructs containing deletions or mutations in the cytoplasmic domain of thrombomodulin were prepared and introduced