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The features of serous retinal detachment in preeclampsia viewed on spectral-domain optical coherence tomography Pregnancy Hypertens. (IF 2.2) Pub Date : 2024-02-29 Shengli Hao, Weiting Hao, Yao Ma
To evaluate the characteristics of serous retinal detachment on spectral-domain optical coherence tomography in preeclampsia. In this retrospective case-series study, clinical characteristics of retinal damage were evaluated using spectral-domain optical coherence tomography (SD-OCT) imaging. Thirty affected eyes from 16 pregnant women with preeclampsia were included. The features of serous retinal
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Urinary concentration of Cathepsin D as a relievable marker of preeclampsia Pregnancy Hypertens. (IF 2.2) Pub Date : 2024-02-25 Rafael Arredondo-Zapien, Maritza G. Verdugo-Molinares, Marco Ku Centurion, Rosendo Benavides-Diosdado, Jose F. Lopez-Rojas, Ricardo Gonzalez-Gonzalez, Jose A. Espinoza-Hernandez, Jorge Gutierrez-Chavez, Laura Cortes Sanabria, Zesergio Melo
The early and accurate diagnosis of preeclampsia is crucial to avoid serious complications for both the mother and baby. However, the current diagnostic methods are limited, and there is a need for new diagnostic biomarkers. Previous studies have shown that cathepsin D (CTD) participates in the pathophysiology of preeclampsia and is present in urine samples, making it a potential biomarker for the
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Use of non-invasive cardiac monitoring to guide discontinuation of postpartum magnesium sulfate in individuals with preeclampsia with severe features Pregnancy Hypertens. (IF 2.2) Pub Date : 2024-02-23 Joe Eid, Marwan M. Ma'ayeh, Sara Post, Christina Darin, Sydney Rentsch, Michael Cackovic, Kara M. Rood, Maged M. Costantine
To determine the utility of using total peripheral systemic vascular resistance assessed using non-invasive cardiac monitor for individualizing the duration of postpartum magnesium sulfate in individuals with preeclampsia with severe features. Single center pilot randomized controlled trial in which singleton pregnant individuals with preeclampsia with severe features were randomized to 24 h of postpartum
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Comparison of clinic and home blood pressure readings in higher risk pregnancies – Secondary analysis of the BUMP 1 trial Pregnancy Hypertens. (IF 2.2) Pub Date : 2024-02-22 Kasper Pihl, Richard J. McManus, Richard Stevens, Katherine L. Tucker
To compare clinic and home blood pressure readings in higher risk pregnancies in the antenatal period from 20 weeks gestation, and to evaluate differences between the two modalities. A cohort study comprising a secondary analysis of a large randomised controlled trial (BUMP 1). Normotensive women at higher risk of pregnancy hypertension randomised to self-monitoring of blood pressure. The primary outcome
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The addition of the sFlt-1/PlGF ratio to the protein/creatinine ratio in multiple pregnancy: Post-hoc analysis of the PREPARE cohort study Pregnancy Hypertens. (IF 2.2) Pub Date : 2024-02-21 M. Wind, L. Dekker, M.E. van den Akker-van Marle, B.E.P.B. Ballieux, C.M. Cobbaert, T.J. Rabelink, J.M.M. van Lith, Y.K.O. Teng, M. Sueters
To assess the predictive accuracy of the sFlt-1/PlGF ratio cut-off 38 in addition to the standard-of-care spot urine protein/creatinine ratio (PCr) for multiple pregnancies in women with suspected pre-eclampsia. Post-hoc analysis of a prospective cohort study. Primary outcome was the occurrence of pre-eclampsia in one and four weeks after presentation with suspected pre-eclampsia. Test characteristics
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Preeclampsia pravastatin early VS late treatment: Effects on oxidative stress and vascular reactivity Pregnancy Hypertens. (IF 2.2) Pub Date : 2024-02-02 Franco A. Ramírez Sanchez, Damian Madrigal Aguilar, Cecilia Tufiño, Seidy Castro García, Rosa A Bobadilla Lugo
Early diagnosis and efficient treatment of preeclampsia remains a medical challenge and etiological factors converge in a deficient placentation that triggers oxidative stress. There is evidence that statins show antioxidant effects that can improve endothelial function without adverse perinatal effects. We aimed to compare early vs. late pravastatin treatment on the oxidative stress and cardiovascular
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Effect of short-term changes in salt intake on plasma cytokines in women with healthy and hypertensive pregnancies Pregnancy Hypertens. (IF 2.2) Pub Date : 2024-01-31 Sai Sindhu Thangaraj, Tina-Signe Gissel Gunlund, Jane Stubbe, Yaseelan Palarasah, Per Svenningsen, Lise Hald Nielsen, Per Glud Ovesen, Boye L. Jensen
Background Salt (NaCl) promotes T-lymphocyte conversion to pro-inflammatory Th-17 cells in vitro. Interleukin (IL)-17A aggravates hypertension in preeclampsia (PE) models. Objectives It was hypothesized that 1) women with PE exhibit increased plasma IL-17A and related cytokines and 2) high dietary salt intake elevates circulating IL-17A in patients with PE compared to women with healthy pregnancy (HP)
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Self-monitoring blood pressure in Pregnancy: Evaluation of health professional experiences of the BUMP trials Pregnancy Hypertens. (IF 2.2) Pub Date : 2024-02-01 Alison Chisholm, Katherine L Tucker, Carole Crawford, Marcus Green, Sheila Greenfield, James Hodgkinson, Layla Lavallee, Paul Leeson, Lucy Mackillop, Christine McCourt, Jane Sandall, Hannah Wilson, Lucy C Chappell, Richard J McManus, Lisa Hinton
The BUMP trials evaluated a self-monitoring of blood pressure intervention in addition to usual care, testing whether they improved detection or control of hypertension for women at risk of hypertension or with hypertension during pregnancy. This process evaluation aimed to understand healthcare professionals’ perspectives and experiences of the BUMP trials of self-monitoring of blood pressure during
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The diagnostic Accuracy of Visual versus automated dipstick proteinuria testing in Pregnancy: A systematic review and Meta-Analysis Pregnancy Hypertens. (IF 2.2) Pub Date : 2024-01-22 C. Jones, B.E. Jakubowski, R. Stevens, N. Roberts, R.J. McManus, K.L. Tucker
Objective: To evaluate the diagnostic accuracy of point-of-care (POC) tests for detecting proteinuria in pregnant women. Design: Systematic review and meta-analysis. Data Sources: MEDLINE and EMBASE databases were searched from inception to 13 November 2020. Eligibility Criteria and Data Analysis: Included studies measured the sensitivity and specificity of POC proteinuria testing compared to laboratory
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Longitudinal changes of angiogenic factors as a potential predictive tool in women with suspected preeclampsia Pregnancy Hypertens. (IF 2.2) Pub Date : 2024-01-20 Jorge Montenegro-Martínez, Ana Camacho-Carrasco, David Nuñez-Jurado, Luis M. Beltrán-Romero, Daniel Fatela-Cantillo
Objectives To investigate whether longitudinal changes of angiogenic factors (AF) sFlt-1, PlGF, and the sFlt-1/PlGF ratio, measured following identification of symptoms of preeclampsia (PE), could provide complementary information to the isolated measurements used in current clinical practice. Study design Retrospective observational study. Sixty women with suspected PE and two AF results measured
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Patients and health care workers perceived challenges in managing preeclampsia, in Malawi Pregnancy Hypertens. (IF 2.2) Pub Date : 2024-01-20 Memory M. Ngwira, Luis A. Gadama, Renuka Shanmugalingam, Angela Makris, Annemarie Hennessy
Objectives This study investigated perceptions of the challenges for patients and health care workers (HCW) in dealing with preeclampsia in Blantyre, Malawi. Methods A descriptive cross-sectional formative study using semi-structured In-Depth Interviews (IDI) was conducted at Queen Elizabeth Central Hospital (QECH), Malawi. Data was analyzed using NVIVO™ software. Thematic content analysis was used
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Social determinants of hypertensive disorders of pregnancy trends in Mexican municipalities Pregnancy Hypertens. (IF 2.2) Pub Date : 2024-01-12 Eduardo Padilla-González, Wendy Marisol Orzua-de la Fuente, Amado D. Quezada-Sanchez, Svetlana V. Doubova, Eduardo Ortiz-Panozo
Objectives To analyze the hypertensive disorders of pregnancy (HDP) trends in the 2000–2020 period and its association with social determinants of health (SDH) in Mexican municipalities. Study design This was a retrospective longitudinal study analyzing data from routine information systems on 21,493,076 hospital discharges due to maternal causes and SDH data of 2,439–2,450 municipalities between 2000
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Persistent postpartum hypertension 3 months post-delivery among women with hypertensive disorders of pregnancy in Tanzania: A multicenter cohort study Pregnancy Hypertens. (IF 2.2) Pub Date : 2024-01-04 Alawiya A. Ahmed, Megan A. Willkens, Dismas Matovelo, Richard Kiritta, Godfrey Kaizilege, Jyoti Mathad, Robert N. Peck
Postpartum care of hypertensive disorders of pregnancy (HDP) often extends only 6 weeks after delivery in low-income countries. This multicenter observational cohort study was conducted to determine 3-month postpartum outcomes of HDP in Tanzania. Of 309 consecutive women admitted to 3 public hospitals, five (1.7 %) died within 3 months. Of the remaining 304, 292 (94.5 %) returned for 3-month follow-up
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Mental health in the two years following hypertensive and normotensive pregnancy: The Postpartum, Physiology, Psychology and Paediatric follow-up (P4) cohort study Pregnancy Hypertens. (IF 2.2) Pub Date : 2024-01-02 Jie Shang, Maree L. Hackett, Katie Harris, Mark Woodward, Lynne M. Roberts, Puhong Zhang, Amanda Henry
Background Postpartum mental illnesses and hypertensive disorders of pregnancy (HDP) are both common, and both associated with adverse maternal and child health outcomes. However, the relationship between them is unclear. This study aimed to investigate prevalence and symptom severity of depression, anxiety, and post-traumatic stress disorder (PTSD) 2-years postpartum in women with normal blood pressure
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Improving obstetric and perinatal outcomes with a remote patient monitoring program for hypertension in a large integrated care system Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-12-30 Fatu Forna, Ericka Gibson, Annette Miles, Philidah Seda, Felipe Lobelo, Armand Mbanya, Belkis Pimentel, Grace Sobers, Serena Leung, Kate Koplan
Objective To determine the effect of a remote patient monitoring program for hypertension (RPM HTN) in patients diagnosed with hypertensive disorders of pregnancy. Study Design We used a matched retrospective cohort design to evaluate differences in obstetric and perinatal outcomes using data from electronic medical records. Patients enrolled in RPM HTN between November 1, 2019, and October 31, 2021
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Association between body mass index and chronic hypertension in patients with hypertension disorders of pregnancy one-year postpartum Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-12-21 Ronald Anguzu, Christine M. Livergood, Kara K. Hoppe, Jacquelyn Kulinski, Garrett D. Fitzgerald, Anna Palatnik
Objectives To determine the association between body mass index (BMI) and chronic hypertension (CHTN) one-year postpartum following pregnancies complicated by hypertensive disorders of pregnancy (HDP). Study design A retrospective cohort study of patients with HDP (gestational hypertension or preeclampsia) in a single Midwestern academic center from 2014 to 2018. The primary outcome was CHTN at one-year
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Pregnancy induces retinal microvascular changes indicating cardio-metabolic stress Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-12-19 Anne Dathan-Stumpf, Holger Stepan, Eva Valterova, Roman Jakubicek, Clara Berbée, Marie-Louise Seidenspinner, Radim Kolar, Franziska G. Rauscher
We performed longitudinal examinations of the arterial retinal microvasculature using Adaptive Optics Retinal Imaging in a 30-year-old healthy woman with twin pregnancy from the 23rd week of gestation (wog) to three days postpartum. Two blinded graders recorded the average wall-to-lumen ratio (WLR) of the examined retinal artery. There was a significant increase in the mean WLR over the course of pregnancy
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Pregnancy outcomes of women presenting with stage 1 hypertension during the first prenatal clinic visit before 20 gestational weeks Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-12-12 Mikovhe Rejoice Mphaphuli, Lawrence Chauke, Nnabuike Chibuoke Ngene
Objective To determine the pregnancy outcomes of women who had 2017 American College of Cardiologists stage 1 hypertension during the first prenatal clinic visit before 20 gestational weeks in a tertiary hospital in South Africa. Study design A retrospective cohort study involving the review of medical records of 127 participants with stage 1 hypertension and 128 control with blood pressure (BP) less
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Validation of the Finnish Care register for Health Care diagnoses for preeclampsia, gestational diabetes and preterm delivery Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-12-12 Elli Toivonen, Kirsi Taurio, Eija Kortelainen, Aki S. Havulinna, Tiina Jääskeläinen, Hannele Laivuori
Background Centrally collected Finnish national health register data on adverse pregnancy outcomes are available for research, but the validity of the data is largely unknown. Our aim was to compare the diagnoses of preeclampsia (PE), gestational diabetes (GDM), and preterm delivery from hospital records with the registry based diagnoses from the Finnish Care Register for Health Care (FCR). Data on
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Low indoleamine 2, 3 dioxygenase (IDO) activity is associated with psycho-obstetric risk Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-12-07 Serena Gumusoglu, Casee R. Meincke, Michaela Kiel, Alexandria Betz, Virginia Nuckols, Lyndsey DuBose, Jessica Steidele, Eileen Sweezer, Donna Santillan, Amy K. Stroud, Gary L. Pierce, Mark K. Santillan
Objectives Preeclampsia and depression in pregnancy are among the most prevalent obstetric disorders with no known cures. While depression and preeclampsia each increase risk for the other, shared mechansisms are unclear. One possibility is low levels of Indoleamine 2,3 dioxygenase (IDO), which links immune dysregulation and oxidative arterial damage resulting in poor vascular function in both preeclampsia
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Eclampsia reduction with maternal early warning trigger tool Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-12-02 Siri Yerubandi, Sailaja Devi Kallur, Anisha Gala, Pallavi Chandra Ravula, Tarakeswari Surapaneni, Nuzhat Aziz
Objectives To observe the incidence of eclampsia before and after implementing Maternal Early Warning Trigger (MEWT) tool. Study design A retrospective observational study to evaluate the effect of introduction of MEWT tool in a tertiary referral center with 10,000 annual births. Two epochs of five years duration were compared before and after implementing MEWT tool. MEWT tool has triggers for early
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Intrapartum trends of NT-proBNP and hs-cTnT in patients with severe features of preeclampsia Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-11-28 Joseph S. Fixler, John J. Byrne, Donald D. Mcintire, David B. Nelson, F. Gary Cunningham
Background Preeclampsia with severe features (SPE) is a multisystem syndrome associated with long-term cardiovascular morbidity. Serum concentrations of N-terminal B-type natriuretic peptide (NT-proBNP) and high sensitivity cardiac troponin-T (hs-cTnT) are sensitive markers of cardiac stretch and ischemia, respectively. Objective Our aim was to examine NT-proBNP and hs-cTnT in patients with SPE during
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Perinatal outcomes and their determinants among women with eclampsia and severe preeclampsia in selected tertiary hospitals, Eastern Ethiopia Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-11-21 Abduro Godana, Seid Tesi, Shambel Nigussie, Mesay Dechasa
Background Neonatal complications and deaths are still increasing worldwide. Therefore, this study aimed to assess perinatal outcomes and their determinants among women with eclampsia and severe preeclampsia admitted to selected tertiary hospitals Eastern Ethiopia. Methods The prospective observational study was conducted among 245 foetal born to women with eclampsia and severe preeclampsia admitted
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Maternal birth weight as an indicator of early-onset and late-onset hypertensive disorders of pregnancy: The Japan Environment and Children’s study Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-11-22 Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Naoto Sato, Seiya Izumi, Kasumi Sakurai, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Tetsuro Hoshiai, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi
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Reference-range of arterial stiffness by cardio-ankle vascular index in normal pregnancy Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-11-16 Thanawit Poolsin, Supatra Sirichotiyakul, Suchaya Luewan, Krit Leemasawat, Theera Tongsong
Objective To establish the arterial stiffness, represented by the cardio-ankle vascular index (CAVI) at various gestational ages among low-risk pregnant women. The second objective is to construct the reference range of mean arterial pressure and maternal heart rate during pregnancy. Methods This cross-sectional study was conducted on low risk pregnant Thai women, meeting the following inclusion criteria:
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The significance of mitochondrial haplogroups in preeclampsia risk Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-11-16 Kristina Wendelboe Olsen, Paula L. Hedley, Christian M. Hagen, Line Rode, Sophie Placing, Karen R. Wøjdemann, Anne-Cathrine Shalmi, Karin Sundberg, Anne Nørremølle, Ann Tabor, Joanna L. Elson, Michael Christiansen
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Association between human chorionic gonadotropin (hCG) levels and adverse pregnancy outcomes: A systematic review and meta-analysis Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-11-09 Johannes Skogler, Tilda Moberg, Luca Tancredi, Lea Styrmisdóttir, Ehsan Hedayati, Christoper A. Alarcon-Ruiz, Assem Khamis, Emma Persad, Ghida Iskandarani, Stefan R Hansson, Matteo Bruschettini
Human chorionic gonadotropin (hCG), a glycoprotein produced in the placenta, is crucial for a healthy pregnancy. We investigated the relationship between hCG levels and adverse pregnancy outcomes. We conducted a systematic review including studies measuring hCG blood levels in the first or second trimester, reporting on any of the 12 predefined adverse pregnancy outcomes with logistic regression-adjusted
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Peripartum cardiomyopathy delivery hospitalization and postpartum readmission trends, risk factors, and outcomes Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-11-09 Hooman Azad, Timothy Wen, Natalie A. Bello, Whitney A. Booker, Stephanie Purisch, Mary E. D'Alton, Alexander M Friedman
Objective To evaluate risk for peripartum cardiomyopathy during delivery and postpartum hospitalizations, and analyze associated trends, risk factors, and clinical outcomes. Methods The 2010–2020 Nationwide Readmissions Database was used for this retrospective cohort study. Delivery hospitalizations along with postpartum readmissions occurring within five months of delivery discharge were analyzed
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Prediction of adverse outcome by ophthalmic artery Doppler and angiogenic markers in pregnancies with new onset hypertension Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-11-04 Katherine G.Y. Lau, Emmanouil Kountouris, Laura Salazar-Rios, Kypros H. Nicolaides, Nikos A. Kametas
Objectives To compare the ophthalmic artery Doppler peak systolic velocity ratio (OA PSV-ratio) and soluble fms-like tyrosine kinase-1/placental growth factor ratio (sFlt-1/PlGF ratio) in predicting adverse maternal and perinatal outcomes in women presenting with new onset hypertension. Study design Prospective cohort study in a specialist hypertension clinic, within a tertiary referral centre. Main
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The role of periodic measurement of sFlt-1 and PlGF in predicting the remaining pregnancy duration in hypertensive disorders of pregnancy Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-11-01 Sho Takakura, Hiroaki Tanaka, Yuya Tamaishi, Naosuke Enomoto, Shoichi Magawa, Shintaro Maki, Masafumi Nii, Kayo Tanaka, Kuniaki Toriyabe, Eiji Kondo, Tomoaki Ikeda
Objectives This study aimed to explore whether one-time or periodic measurement of soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) could contribute to the prediction of the remaining pregnancy duration in hypertensive disorders of pregnancy. Study design In this retrospective study, we enrolled pregnant women with singleton pregnancies who were admitted to our hospital
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First trimester circulating miR-194-5p and miR-1278 improve prediction of preeclampsia Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-10-28 Andrée-Anne Clément, Cécilia Légaré, Véronique Desgagné, Kathrine Thibeault, Frédérique White, Michelle S. Scott, Pierre-Étienne Jacques, William D. Fraser, Patrice Perron, Renée Guérin, Marie-France Hivert, Anne-Marie Côté, Luigi Bouchard
Objectives To identify first trimester circulating microRNAs associated with preeclampsia (PE) and assess their predictive value in two independent cohorts Methods Circulating microRNAs were quantified from plasma samples collected at first trimester of pregnancy in women from Gen3G (discovery; N = 385 normotensives/22 PE) and 3D (replication; N = 260 normotensives/24 PE) prospective birth cohorts
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Nutricional intake, maternal outcomes and knowledge on preeclampsia prevention: Was there impact during the COVID-19 pandemic among women with hypertension? Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-10-17 Erika Ferreira de Sousa, Maria Julia Miele, José Paulo Guida, Patricia Moreti Rehder, Fernanda Garanhani Surita, Maria Laura Costa
Aim Compare nutritional intake, weight gain, frequency of superimposed pre-eclampsia (SPE) and adequate use/knowledge on preventive interventions for PE, before and during the COVID-19 pandemic among pregnant women with chronic hypertension (CH) Methods Prospective cohort of pregnant women with CH. Inclusion between 13 and 25 weeks, with sociodemographic characterization, food frequency questionnaire
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Withstanding the test of time: Morning versus afternoon/evening urine protein-to-creatinine ratios in preeclampsia Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-10-21 Shahd Karrar, Joshua Fogel, Peter Hong
Objective There are mixed findings regarding time preference for measuring spot urine protein to creatinine ratios (UPCR) in renal patients but no such literature among pregnant patients. We compare AM versus PM measurements for UPCR among pregnant patients with preeclampsia. Study design This retrospective study included 163 patients diagnosed with preeclampsia. Laboratory tests of UPCR, urine specificity
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Treatment of acute-onset hypertension in pregnancy: A network meta-analysis of randomized controlled trials comparing anti-hypertensives and route of administration Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-10-17 Adithya D. Bhat, Paige M. Keasler, Lavanya Kolluru, Michael M. Dombrowski, Arvind Palanisamy, Preet Mohinder Singh
Background Consensus on the relative efficacy of available antihypertensive agents used in pregnancy is lacking. Objective To compare treatment success with antihypertensives and categorize by route of administration. Search strategy MEDLINE, Embase, PubMed, Web of Science, Scopus, CINAHL, and clinicaltrials.gov were searched without date restriction. Data collection Peer-reviewed randomized controlled
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Src kinase partially mediates cytokine-induced endothelial dysfunction Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-10-19 Amanda K. Mauro, Luca Clemente, Nauman Khurshid, Dinesh M. Shah, Jing Zheng, Derek S. Boeldt
Objectives Endothelial dysfunction is known to be a key characteristic of preeclampsia (PE) and can contribute to progression of symptoms and injury to multiple organ systems. Delivery is the only treatment for progression of PE, but development of an endothelial-based therapy for PE presents a promising strategy. Growth factors and cytokines are dysregulated in PE and can impact endothelial function
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Association of activin A and postpartum blood pressure in peripartum cardiomyopathy Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-10-16 Agnes Koczo, Amy Marino, Vincenzo B. Polsinelli, Rami Alharethi, Julie Damp, Gregory Ewald, Michael M. Givertz, John Boehmer, Karen Hanley-Yanez, Sarosh Rana, Jason Roh, Dennis M. McNamara
Background Activin A has been implicated in the pathogenesis of patients with chronic hypertension and heart failure as well as patients with hypertensive disorders of pregnancy (HDP). Whether activin A correlates with blood pressure in patients with peripartum cardiomyopathy (PPCM) and HDP history has not previously been explored. Methods and results 82 women with PPCM w/ and w/out HDP or hypertension
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The challenge of adequately reporting preeclampsia for epidemiological surveillance: An example from a referral center in a middle-income country Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-10-11 Juliana da-Costa-Santos, Christopher Cralcev, Marcos Marangoni-Junior, Mariana Peccia Sanchez, José Paulo Siqueira Guida, José Guilherme Cecatti, Maria Laura Costa
Adequately reporting of preeclampsia is a challenge. The aim of this study was to compare the diagnosis of preeclampsia based on clinical and laboratory findings and ICD-10 codes (International Classification of Diseases) at admission and discharge in a referral center, over a one-year period. Among 2,839 women admitted for childbirth, 208 presented confirmed preeclampsia, based on chart audits. Among
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Association of plasma Decorin levels and markers of glycocalyx disruption with adverse events in women with severe preeclampsia Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-10-14 R. Saranya, Dilip Kumar Maurya, Gowri Dorairajan, Zachariah Bobby, Pankaj Kundra, Anish Keepanasseril
Identifying preeclamptic women with an increased risk of severe maternal complications can aid in timely interventions to optimize pregnancy outcomes. Newer biomarkers such as Decorin and markers of endo glycocalyx disruption were assessed in earlier studies for its role in predicting preeclampsia, but their role in identifying those with adverse maternal outcomes is limited. This study aimed to evaluate
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Antenatal risk stratification for preeclampsia with sFlt-1/PlGF ratio: Which is the best time to test? Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-10-04 Manisha Kumar, Kirti Balyan, Ekta Debnath, Ben Himtsoe, Surbhi Sapna, Arunav Kumar
Objective To find out the predictive value of sFlt-1/PlGF ratio for antenatal risk stratification (ARS) of women at high risk of preeclampsia (PE). Methods Antenatal women at high risk of PE underwent sFlt-1/PlGF ratio at 20–22, 28–30 and 34–36 weeks and were followed till delivery. Those who developed PE were cases those who had normal outcome were controls, the cases and controls were compared. Results
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Effect of tenofovir alafenamide in combination with and without integrase inhibitors on weight gain, diabetes, and hypertensive disorders of pregnancy Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-10-05 Oriel A. Nissim, Ashley Haney, Gweneth Bratton Lazenby
Objectives We sought to determine if tenofovir alafenamide (TAF) was associated with excessive weight gain, diabetes (DM), and hypertensive disorders of pregnancy (HDP) in persons with HIV. Study design This is a retrospective cohort study of pregnant persons with HIV prescribed antiretroviral therapy (ART) during the period of 01/01/2009 to 12/31/2020. Main outcomes measures χ2 tests were used to
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Continuous non-invasive hemodynamic monitoring in early onset severe preeclampsia Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-09-30 Christina M. Ackerman-Banks, Jasjit Bhinder, Maxwell Eder, Paul Heerdt, Lissa Sugeng, Jeffrey Testani, Aymen Alian, Heather Lipkind, Eric Velazquez, Uma Reddy, Josephine C. Chou
Objectives Continuous hemodynamic monitoring offers the opportunity to individualize management in severe preeclampsia (PEC). We compared cardiac output (CO) and total peripheral resistance (TPR) measured by bioreactance (NICOM), Clearsite™ Fingercuff [CS), and 3D-echocardiography (3DE). Study design This prospective observational study included 12 pregnant patients with early PEC. CO and TPR were
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Patient and provider perception of home blood pressure monitoring kits Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-09-30 Courtney Bisson, Sydney Dautel, Ariel Mueller, Rebecca Britt, Easha Patel, Sunitha Suresh, Eleni Tsigas, Sarosh Rana
Background Pregnant patients of racial/ethnic minorities have higher preeclampsia rates. Home blood pressure monitoring (HBPM) has been investigated for disparity reduction. Smaller studies showed patients find HBPM to be a helpful intervention postpartum. Further investigation is needed to define the role of HPBM in an at-risk and diverse population antepartum. Objective To assess patient perception
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Is a sFlt-1/PlGF cutoff of 38 suitable to predict adverse outcomes in pregnancies with abnormal uterine artery Doppler velocimetry in the second trimester? Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-09-29 Sara Caamiña Álvarez, Alicia Rodríguez Zurita, Tania del Carmen De Ganzo Suárez, José Fernando De Luis Escudero, Nieves Sierra Medina, Carolina Chulilla Pérez, Cecilia Martín Fernández de Basoa, José Luis Trabado Montesino, María Teresa Concepción Masip, Miguel Ángel García Bello
Objective To determine the optimal cutoff value for the soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio to predict maternal and fetal adverse events in pregnancies with uterine artery Doppler scans results above the 95th percentile in the late second trimester. Study design Retrospective, observational cohort study on 116 asyntomatic patients with abnormal uterine artery
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Increased adherence to ACOG diagnostic guidelines for HDP following a workshop in Bolivia, a LMIC Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-09-29 Lilian Toledo-Jaldin, Litzi Lazo-Vega, Laura Grau, Ian Lawrence, Alison Larrea-Alvarado, Rodrigo Mizutani, Sebastian Rocabado, Vikram Vasan, Mary Sammel, Colleen G. Julian, Lorna G. Moore
Objectives Hypertensive disorders of pregnancy (HDP) exert a heavy mortality burden in low- to middle-income countries (LMIC). ACOG revised HDP diagnostic guidelines to improve identifying pregnancies at greatest risk but whether they are used in LMIC is unknown. Study design We held a workshop to review ACOG guidelines in La Paz, Bolivia (BO) and then reviewed prenatal, labor and delivery records
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Hypertensive pregnancy complications and maternal characteristics as predictors of cardiovascular health within ten years after delivery Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-09-12 Anni Kivelä, Seppo Heinonen, Katja Kivinen, Juha Kere, Eero Kajantie, Tiina Jääskeläinen, Hannele Laivuori
Objective To identify the combination of maternal characteristics in women with hypertensive disorders of pregnancy (HDP) associated with hypertensive and other cardiovascular diseases (CVDs) within ten years following delivery. The aim is to understand who should receive the most intensive primary cardiovascular disease prevention. Study design A prospective cohort study. Main outcome The population
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Provider adherence to aspirin prophylaxis prescription guidelines for preeclampsia Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-09-09 Mariam Ayyash, Gregory Goyert, D'Angela Pitts, Raminder Khangura, Robyn Garcia, Gordon Jacobsen, Majid Shaman
Objective To evaluate provider adherence to aspirin prophylaxis prescription guidelines for patients at risk. Study Design A retrospective chart review was performed at Henry Ford Health (HFH) between October 2015 and December 2020. In October 2015, low-dose aspirin was recommended for women who met high risk criteria for preeclampsia at HFH; in February 2019, aspirin recommendation expanded to include
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Impact of antenatal care on severe maternal and neonatal outcomes in pregnancies complicated by preeclampsia and eclampsia in Ghana Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-08-14 Titus K. Beyuo, Emma R. Lawrence, Samuel A. Oppong, Emily K. Kobernik, Mary Amoakoh-Coleman, Diederick E. Grobbee, Joyce L. Browne, K.W.M. Bloemenkamp
Objectives To explore how specific measures of antenatal care utilization are associated with outcomes in pregnancies complicated by preeclampsia and eclampsia in Ghana. Study Design Participants were adult pregnant women with preeclampsia or eclampsia at a tertiary hospital in Ghana. Antenatal care utilization measures included timing of first visit, total visits, facility and provider type, and referral
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Dynamic cerebral autoregulation in postpartum individuals with and without preeclampsia Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-07-29 Eliza C. Miller, Maria I. Katsidoniotaki, Noora Haghighi, Ketson R.M. Dos Santos, Whitney A. Booker, Nils Petersen, Ronald Wapner, Natalie A. Bello, Ioannis A. Kougioumtzoglou, Randolph S. Marshall
Background Changes in dynamic cerebral autoregulation (DCA) may contribute to postpartum maternal cerebrovascular complications after preeclampsia. We hypothesized that DCA is impaired in the first week postpartum after diagnosis of preeclampsia with severe features (PSF), compared with normotensive postpartum individuals and healthy non-pregnant female volunteers. Methods We measured DCA within seven
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The association of out-of-hospital postpartum NSAID use and post-discharge hypertension control for people with hypertensive disorders of pregnancy Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-07-18
Objective To evaluate the relationship between amount of NSAID use postpartum and outpatient blood pressure (BP) control. Study design This is a prospective, single-site, cohort study of postpartum people diagnosed with HDP from 2018 to 2020 using the American College of Obstetrician and Gynecologists criteria. All participants were provided an electronic BP cuff for daily evaluation after discharge
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Letter to editor – Placental basal plate myofibers and risk of hypertensive disorders of pregnancy Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-07-07 Kamran Hessami, Jimmy Espinoza, Bahram Salmanian, Eumenia Castro, Alireza A. Shamshirsaz, Amir A. Shamshirsaz
Abstract not available
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Corrigendum to “Low physical activity levels 1 year after pregnancy complications” [Pregnancy Hyperten. 25 (2021) 136–142] Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-07-05 Charlotte P.Ø. Ziesler, Anne Cathrine Staff, Meryam Sugulle, Kjartan Moe
Abstract not available
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Hypertensive disorders of pregnancy and occurrence of ADHD, ASD, and epilepsy in the child: A meta-analysis Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-06-23 Tiffany Xiu Zhen Lim, Trevor A. Pickering, Richard H. Lee, Isabella Hauptman, Melissa L. Wilson
Aim To synthesize epidemiologic literature pertaining to the association between preeclampsia (PE), attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and epilepsy. Method A systematic search of PubMed and Embase was performed supplemented by hand-searching of reference lists of eligible studies. Two independent reviewers screened abstracts following a prepared protocol
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The prevalence and perinatal repercussions of preeclampsia after the implementation of a prophylaxis protocol with aspirin Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-06-14 Maria Isabel M.P. Cardoso, Karina B. de C. Rezende, Fabio G Da Matta, Cláudia Saunders, Fernanda F.O. Cardoso, Ivo B Costa Junior, Luiza B. Gama, Joffre Amim Jr, Rita G. Bornia
Objectives To evaluate the prevalence and perinatal repercussions of preeclampsia (PE) after the implementation of a prophylaxis protocol with aspirin in singleton pregnancy at Maternity School of Federal University of Rio de Janeiro, Rio de Janeiro, Brazil (2015–2106). Methodology PE prevalence according to gestational age (GA) and the prevalence ratio (PR) between PE and prematurity, small for gestational
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Racial differences in healthcare utilization among patients with suspected or diagnosed preeclampsia: A retrospective cohort study Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-05-26 N. Docheva, D. Woelkers, W. Yao, Y. Jin, J. Espinoza, L. Kunz, C. Amegashie, M. Gencay, J. Harris, S. Rana
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Expediting labor induction in severe pre-eclampsia by earlier initiation of oxytocin after cervical ripening: A randomized study from India Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-05-23 Himani Jangra, Rashmi Bagga, Jasvinder Kalra, Vanita Jain, Subhas Chandra Saha, Praveen Kumar
Objective To observe whether induction of labor (IoL) among women with severe pre-eclampsia (PE) can be expedited by initiating oxytocin early (after 6 h) than after 12 h following cervical ripening with a combined method. Methods Women with severe PE and Bishop’s < 6 (n = 96) were randomized into two groups. All women received cervical ripening with a combined method (intracervical Foley’s plus dinoprostone
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A retrospective cohort study of hypertension, cardiovascular disease, and metabolic syndrome risk in women with history of preterm and term preeclampsia five years after delivery Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-04-26 , Noor Assyifa Zulhijayanti, Ernawati Ernawati, Muhammad Ilham Aldika Akbar
Objectives To evaluate maternal hypertension, risk of cardiovascular disease (CVD), and metabolic syndrome five years after delivery in preterm preeclampsia (P-PE), term preeclampsia (T-PE), and normal pregnancy. Study design This was a retrospective cohort study of women who delivered at Dr. Soetomo Academic Hospital (Indonesia) in 2013 with a diagnosis of PE and were compared with women with normal
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Prediction of adverse neonatal outcome at admission for early-onset preeclampsia with severe features Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-04-26 Anna Peguero, Lorena Fernandez-Blanco, Edurne Mazarico, Leticia Benitez, Alba Gonzalez, David Boada, Cristina Borràs, Lina Youssef, Fàtima Crispi, Sandra Hernandez, Francesc Figueras
Background Preeclampsia remains the leading cause of maternal morbidity and mortality. Consequently, research has focused on validating tools to predict maternal outcomes regarding clinical and biochemical features from the maternal compartment. However, preeclampsia also leads to neonatal complications due to placental insufficiency and prematurity, being the early-onset type associated with the poorest
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RUPP Th17s cause hypertension and mitochondrial dysfunction in the kidney and placenta during pregnancy Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-04-25 Sarah Fitzgerald, Evangeline Deer, James Hogg, Denise C. Cornelius, Ty Turner, Lorena M. Amaral, Ngoc Hoang, Kristin Edwards, Owen Herrock, Nathan Campbell, Tarek Ibrahim, Babbette LaMarca
Background Preeclampsia (PE), new-onset hypertension (HTN), and organ dysfunction during the second half of pregnancy, is associated with an increase in inflammatory immune cells, including T helper 17 (Th17) cells. Studies have demonstrated that mitochondrial (mt) dysfunction is important in the pathogenesis of PE though causative factors have yet to be fully identified. Although Th17 cells, natural
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Pre-eclampsia is associated with complement pathway activation in the maternal and fetal circulation, and placental tissue Pregnancy Hypertens. (IF 2.2) Pub Date : 2023-04-21 Hannah Blakey, Ruyue Sun, Long Xie, Rebecca Russell, Nadia Sarween, James Hodson, Beata Hargitai, Tamas Marton, Desley A H Neil, Edwin Wong, Neil S Sheerin, Kate Bramham, Claire L Harris, Ellen Knox, Mark Drayson, Graham Lipkin
Objectives Pre-eclampsia (PE) is a leading cause of obstetric morbidity, with no definitive therapy other than delivery. We aimed to compare complement markers in maternal and fetal circulation, and placental tissue, between women with PE and healthy pregnant controls. Study Design: Maternal and umbilical cord blood was tested for iC3b, C3, C4, properdin, Ba and C5b-9, and placental tissue for C3d