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Risk factors for venous thromboembolism in a single pediatric intensive care unit in China Thromb. J. (IF 3.1) Pub Date : 2024-03-15 Jintuo Zhou, Yanting Zhu, Ying Liu, Hairong Zhan, Peiguang Niu, Huajiao Chen, Jinhua Zhang
Analyses of extensive, nationally representative databases indicate a rising prevalence of venous thromboembolism (VTE) among critically ill children. However, the majority of studies on childhood VTE have primarily concentrated on Caucasian populations in the United States and European countries. There is a lack of epidemiological studies on VTE in Chinese children. We conducted a retrospective cohort
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Successful retrieval of tip-embedded inferior vena cava filter using a modified forceps technique: case report Thromb. J. (IF 3.1) Pub Date : 2024-03-12 Yang Liu, Junlong Ma, Qiqi Wang, Wei Zeng, Chunshui He
The retrieval of inferior vena cava (IVC) filter is essential for preventing complications associated with the device. Advanced techniques have been developed to improve the success rate of retrieving tip-embedded filters. The forceps technique is frequently used to address this issue. We present a case study of two patients who underwent a successful tip-embedded IVC filter retrieval using a modified
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Clot time ratio (CTR) and relation to treatment outcome in patients with atrial fibrillation treated with Rivaroxaban Thromb. J. (IF 3.1) Pub Date : 2024-03-01 Liselotte Onelöv, Elvar Theodorsson, Mojca Božič-Mijovski†, Alenka Mavri
There are situations where information about the anticoagulant effects of Rivaroxaban could be clinically useful. Methods for measuring Rivaroxaban concentrations are not available at all medical laboratories while the test MRX PT DOAC for measuring the functional effects of Rivaroxaban, in CTR (Clot Time Ratio), can be made available around the clock. The objectives of this study were to investigate
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Comparative effectiveness and safety of DOACs vs. VKAs in treatment of left ventricular thrombus- a meta-analysis update Thromb. J. (IF 3.1) Pub Date : 2024-03-01 Tong Hu, Changli Chen, Kellina Maduray, Wenqiang Han, Tongshuai Chen, Jingquan Zhong
Left ventricular thrombus (LVT) formation in patients with acute myocardial infarction (AMI) or cardiomyopathies is not uncommon. The optimal oral anticoagulation therapy for resolving LVT has been under intense debate. Vitamin K antagonists (VKAs) remain the anticoagulant of choice for this condition, according to practice guidelines. Evidence supporting the use of direct oral anticoagulants (DOACs)
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Implementation of early prophylaxis for deep-vein thrombosis in intracerebral hemorrhage patients: an observational study from the Chinese Stroke Center Alliance Thromb. J. (IF 3.1) Pub Date : 2024-02-28 Ran Zhang, Weige Sun, Yana Xing, Yongjun Wang, Zixiao Li, Liping Liu, Hongqiu Gu, Kaixuan Yang, Xin Yang, Chunjuan Wang, Qingbo Liu, Qian Xiao, Weixin Cai
There is substantial evidence to support the use of several methods for preventing deep-vein thrombosis (DVT) following intracerebral hemorrhage (ICH). However, the extent to which these measures are implemented in clinical practice and the factors influencing patients’ receipt of preventive measures remain unclear. Therefore, we aimed to evaluate the rate of the early implementation of DVT prophylaxis
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Establishment and validation of a nomogram predicting the risk of deep vein thrombosis before total knee arthroplasty Thromb. J. (IF 3.1) Pub Date : 2024-02-16 Zehua Wang, Xingjia Mao, Zijian Guo, Guoyu Che, Changxin Xiang, Chuan Xiang
This study aimed to analyze the independent risk factors contributing to preoperative DVT in TKA and constructed a predictive nomogram to accurately evaluate its occurrence based on these factors. The study encompassed 496 patients who underwent total knee arthroplasty at our hospital between June 2022 and June 2023. The dataset was randomly divided into a training set (n = 348) and a validation set
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Association of inherited thrombophilia mutations and their combinations among palestinian women with unexplained recurrent miscarriage Thromb. J. (IF 3.1) Pub Date : 2024-02-13 Ayman A. Najjar, Imam Hassouna, Mahmoud A. Srour, Hany M. Ibrahim, Randa Y. Assi, Heba M. Abd El Latif
Inherited thrombophilia (IT) has a complex pathophysiology and is associated with recurrent miscarriage (RM) by causing placental insufficiency and inhibiting fetal development. However, thrombophilia screening in unexplained RM cases is still questionable. This study aimed to investigate the association between the common eight IT mutations and their combinations among Palestinian women with unexplained
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SERPINC1 c.1247dupC: a novel SERPINC1 gene mutation associated with familial thrombosis results in a secretion defect and quantitative antithrombin deficiency Thromb. J. (IF 3.1) Pub Date : 2024-02-12 Maximilian Ruf, Sarah Cunningham, Alexandra Wandersee, Regine Brox, Susanne Achenbach, Julian Strobel, Holger Hackstein, Sabine Schneider
Antithrombin (AT) is an important anticoagulant in hemostasis. We describe here the characterization of a novel AT mutation associated with clinically relevant thrombosis. A pair of sisters with confirmed type I AT protein deficiency was genetically analyzed on suspicion of an inherited SERPINC1 mutation. A frameshift mutation, c.1247dupC, was identified and the effect of this mutation was examined
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Thrombosis-related characteristics of pregnant women with antithrombin deficiency, protein C deficiency and protein S deficiency in Japan Thromb. J. (IF 3.1) Pub Date : 2024-02-08 Takao Kobayashi, Kazuko Sugiura, Toshiyuki Ojima, Mariko Serizawa, Kyuya Hirai, Eriko Morishita
We previously conducted a primary survey of pregnant women with hereditary thrombophilia based on national surveillance in Japan, but did not examine their thrombosis-related characteristics. Antithrombin (AT) deficiency, protein C (PC) deficiency and protein S (PS) deficiency are the major types of hereditary thrombophilia in Japan. We examined their detailed information related to thrombosis, and
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Efficacy and safety of anticoagulant for treatment and prophylaxis of VTE patients with renal insufficiency: a systemic review and meta-analysis Thromb. J. (IF 3.1) Pub Date : 2024-02-05 Shuangshuang Ma, Guohui Fan, Feiya Xu, Xiaomeng Zhang, Yinong Chen, Yuzhi Tao, Yishan Li, Yanshuang Lyu, Peiran Yang, Dingyi Wang, Zhenguo Zhai, Chen Wang
Patients with venous thromboembolism (VTE) comorbid renal insufficiency (RI) are at higher risk of bleeding and thrombosis. Recommendations in guidelines on anticoagulation therapy for those patients remain ambiguous. The goal of this study is to compare the efficacy and safety between different anticoagulant regimens in VTE patients comorbid RI at different stages of treatment and prophylaxis. We
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Causes of death after first time venous thromboembolism Thromb. J. (IF 3.1) Pub Date : 2024-02-01 Frida Lonnberg, Andreas Roos, Maria Farm, André Heurlin, Mantas Okas, Bruna Gigante, Anwar J Siddiqui
Causes of death after first time community-acquired venous thromboembolism (VTE) diagnosed in unselected patients at the emergency department (ED) was investigated. The study consists of all patients > 18 years of age who had a visit for any medical reason to any of 5 different ED in Stockholm County, Sweden from 1st January 2016 to 31st December 2017. We have identified all patients with a first registered
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Nomogram for hospital-acquired venous thromboembolism among patients with cardiovascular diseases Thromb. J. (IF 3.1) Pub Date : 2024-01-30 Qin Luo, Xin Li, Zhihui Zhao, Qing Zhao, Zhihong Liu, Weixian Yang
Identifying venous thromboembolism (VTE) is challenging for patients with cardiovascular diseases due to similar clinical presentation. Most hospital-acquired VTE events are preventable, whereas the implementation of VTE prophylaxis in clinical practice is far from sufficient. There is a lack of hospital-acquired VTE prediction models tailored specifically designed for patients with cardiovascular
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Detecting prokaryote-specific gene and other bacterial signatures in thrombi from patients with acute ischemic stroke Thromb. J. (IF 3.1) Pub Date : 2024-01-23 Xiaoke Wang, Jie Gao, Yantong Chen, Xiaohao Zhang, Zhengze Dai, Qiliang Dai, Mengna Peng, Lulu Xiao, Xuerong Jia, Haodi Cai, Tao Mou, Xiang Li, Gelin Xu
Microbial infection has been associated with thrombogenesis. This study aimed to detect bacterium-specific genes and other signatures in thrombi from patients with acute ischemic stroke and to relate these signatures to clinical characteristics. Blood samples were collected before thrombectomy procedures, and thrombus samples were obtained during the procedure. Identification and classification of
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Spontaneous coronary artery dissection in a young patient with antiphospholipid syndrome Thromb. J. (IF 3.1) Pub Date : 2024-01-17 Ai Phi Thuy Ho, Eirik Tjønnfjord, Oliver Meyerdierks, Ellen Elisabeth Brodin
A 28-year-old man diagnosed with triple positive antiphospholipid syndrome (APS) and undergoing warfarin experienced three separate admissions to the cardiac ward within a one-month period due to escalating chest pain. While the initial two admissions revealed normal results in cardiological investigations, such as blood tests, electrocardiogram, and echocardiography, the third admission unveiled signs
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Regulation of tissue factor activity by interaction with the first PDZ domain of MAGI1 Thromb. J. (IF 3.1) Pub Date : 2024-01-17 Mohammad A. Mohammad, Sophie Featherby, Camille Ettelaie
Tissue factor (TF) activity is stringently regulated through processes termed encryption. Post-translational modification of TF and its interactions with various protein and lipid moieties allows for a multi-step de-encryption of TF and procoagulant activation. Membrane-associated guanylate kinase-with inverted configuration (MAGI) proteins are known to regulate the localisation and activity of a number
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Factors influencing DVT formation in sepsis Thromb. J. (IF 3.1) Pub Date : 2024-01-16 Lu Wang, Xudong Ma, Yujie Chen, Sifa Gao, Wei Pan, Jieqing Chen, Longxiang Su, Huaiwu He, Yun Long, Chang Yin, Xiang Zhou
Sepsis is a global public health burden. Deep vein thrombosis (DVT) is the third most common cause of death from cardiovascular disease after heart attacks and strokes. We designed this experiment to investigate the factors influencing DVT formation in patients with sepsis. In this survey, 918 septic patients admitted to Peking Union Medical College Hospital, who underwent DVT screening were enrolled
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Effects of combination therapy of antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation: a systematic review and meta-analysis Thromb. J. (IF 3.1) Pub Date : 2024-01-15 Takaaki Totoki, Yuto Makino, Kazuma Yamakawa, Hiroyuki Koami, Takeshi Wada, Takashi Ito, Toshiaki Iba
Disseminated intravascular coagulation (DIC) syndrome is a highly lethal condition characterized by the complication of multiple organ damage. Although the effects of combined antithrombin (AT) and recombinant thrombomodulin (rTM) on DIC syndrome have previously been examined, the results are inconsistent and inconclusive. Therefore, we conducted a systematic review on the combined administration of
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Oxidative stress in acute pulmonary embolism: emerging roles and therapeutic implications Thromb. J. (IF 3.1) Pub Date : 2024-01-12 Jingchao Yang, Jinzhu Xu, Shuanglan Xu, Zeqin Fan, Chenshao Zhu, Jianyuan Wan, Jiao Yang, Xiqian Xing
Oxidative stress is an imbalance between the body’s reactive oxygen species and antioxidant defense mechanisms. Oxidative stress is involved in the development of several cardiovascular diseases, such as pulmonary hypertension, atherosclerosis, and diabetes mellitus. A growing number of studies have suggested the potential role of oxidative stress in the pathogenesis of pulmonary embolism. Biomarkers
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Progress in the clinical effects and adverse reactions of ticagrelor Thromb. J. (IF 3.1) Pub Date : 2024-01-10 Peng Wei, Xiaoqing Wang, Qiang Fu, Bangming Cao
Ticagrelor is a novel receptor antagonist that selectively binds to the P2Y12 receptor, thereby inhibiting adenosine diphosphate (ADP)-mediated platelet aggregation. Compared to clopidogrel, ticagrelor has the advantages of a fast onset, potent effects, and a reversible platelet inhibition function, which make this drug clinically suitable for treating acute coronary syndrome (ACS), especially acute
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Acute caval thrombosis leading to obstructive shock in the early post insertion period of an inferior vena cava filter: a case report and literature review Thromb. J. (IF 3.1) Pub Date : 2024-01-10 ShuTing Gao, YunFei Chen, YaTing Huang, YiPing Dang, YiQing Li
Obstructive shock is extremely rare in clinical practice and is caused by acute blood flow obstruction in the central vessels of either the systemic or pulmonary circulation. Utilizing inferior vena cava filters (IVCFs) to prevent pulmonary embolism (PE) is associated with some potential complications, such as inferior vena cava thrombosis (IVCT). Shock as a direct result of IVCT is rare. We present
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Risk factors for peripherally inserted central catheter-related venous thrombosis in adult patients with cancer Thromb. J. (IF 3.1) Pub Date : 2024-01-04 Pinghu Wang, Lianxiang He, Qiong Yuan, Juan Lu, Qingqiong Ji, An Peng, Wanli Liu
The purpose of this study was to understand and analyze the risk factors of peripherally inserted central catheter (PICC)-related venous thrombosis in adult patients with cancer. This observational cohort study included adult patients with cancer who underwent color Doppler ultrasound at the Xiangya Hospital of Central South University, Hunan Provincial Maternal and Child Healthcare Hospital, and Xiangya
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Association between antithrombotic therapy and mortality in patients hospitalized for COVID‑19 Thromb. J. (IF 3.1) Pub Date : 2024-01-04 Xing Wang, Wuqian Chen, Jiulin Guo, Xingyu Qiu, Chao You, Lu Ma
The prothrombotic state is a common abnormality in patients with coronavirus disease 2019 (COVID-19). However, there is controversy over the use of anticoagulants, especially oral anticoagulants (OAC) due to limited studies. We sought to evaluate the association between antithrombotic therapy on mortality and clinical outcomes in patients hospitalized for COVID-19 through propensity score matching
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A primary pulmonary artery sarcoma masquerading pulmonary embolism: a case report and literature review Thromb. J. (IF 3.1) Pub Date : 2024-01-04 Zhiyue Liu, Lili Fan, Shichu Liang, Zhong Wu, He Huang
Primary pulmonary artery sarcoma (PAS) is an extremely rare malignant tumor with a poor prognosis. The clinical manifestations of PAS are diverse, including dyspnea, chest pain, cough, and hemoptysis. The poor prognosis is often due to delayed diagnosis caused by similarity in imaging findings with pulmonary thromboembolism (PTE). These cues of diagnosis include the “wall eclipsing sign”, lobulated
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Diagnostic and prognostic potential of long non-coding RNA NORAD in patients with acute deep vein thrombosis and its role in endothelial cell function Thromb. J. (IF 3.1) Pub Date : 2024-01-02 Kun Zhou, Na Li, Jia Qi, Pingping Tu, Yan Yang, Hui Duan
Deep venous thrombosis (DVT) is the common clinical cardiovascular disease, and easily develops into post-thrombotic syndrome (PTS). The study aimed to examine the clinical value of long non-coding RNA NORAD gene in the development of DVT and PTS. In vitro, the underlying mechanism was explored. Serum levels of lncRNA NORAD gene in 85 DVT cases and 85 healthy individuals were tested. The role of lncRNA
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The efficacy and safety of direct oral anticoagulants compared with vitamin K antagonist in patients with hypertrophic cardiomyopathy and atrial fibrillation Thromb. J. (IF 3.1) Pub Date : 2024-01-02 Si-qi Lyu, Jun Zhu, Juan Wang, Shuang Wu, Han Zhang, Xing-hui Shao, Yan-min Yang
The benefit-risk profile of direct oral anticoagulants (DOAC) therapy in patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF) has not been well established yet. This study aimed to evaluate the efficacy and safety of DOAC compared with vitamin K antagonists (VKA) in patients with HCM and AF. PubMed, EMBASE, the Cochrane Library, and clinicaltrials.gov were searched to identify
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A study of recurrent life-threatening thrombosis accompanied with the duplication of the factor IX gene Thromb. J. (IF 3.1) Pub Date : 2024-01-02 Xuqian Wei, Houliang Zhang, Weibin Chen, Jian Zhang, Jing Dai
Hereditary predisposition play an important role in thrombosis, especially in younger patients. Here we studied a young patient who experienced three different episodes of severe thromboses, some of which were life-threatening (pulmonary artery thrombosis, portal and mesenteric vein thrombosis, and arterial thrombosis of the lower leg). Blood levels of clotting related indicators were assessed. We
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Management of edoxaban therapy and clinical outcomes in patients undergoing major or nonmajor surgery: a subanalysis of the EMIT-AF/VTE study Thromb. J. (IF 3.1) Pub Date : 2023-12-14 Christian von Heymann, Martin Unverdorben, Paolo Colonna, Amparo Santamaria, Manish Saxena, Thomas Vanassche, Sabine Köhler, Amanda P. Borrow, James Jin, Cathy Chen
Optimising periprocedural management of direct oral anticoagulation in patients with atrial fibrillation on chronic treatment undergoing major surgeries is an important aspect of balancing the risk of surgery-related bleeding with the risk of thromboembolic events, which may vary by surgery type. This subanalysis of the prospective EMIT-AF/VTE programme assessed periprocedural-edoxaban management,
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Multiple venous thromboembolisms in a pregnant patient carrying a novel mutation in SERPINC1 (p.M313T) that causes a transient antithrombin deficiency: a case report Thromb. J. (IF 3.1) Pub Date : 2023-12-13 Yuwen Huang, Yinling Wang, Xiaoli Wang, Jue Liu, Bing Luo, Yuanmei Gao
Congenital antithrombin deficiency is an autosomal dominant disease that results in deep venous thrombosis and pulmonary embolism, which is mainly caused by mutations in the antithrombin gene (SERPINC1). Since SERPINC1 is highly susceptible to alterations, severe structural and functional changes that promote thrombosis may occur. Clinical presentations vary from different alterations. We report a
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Hemostatic potential of recombinant von Willebrand factor and standard or pegylated extended half-life recombinant factor VIII on thrombus formation under high shear flow Thromb. J. (IF 3.1) Pub Date : 2023-12-08 Hiroaki Yaoi, Yasuaki Shida, Kenichi Ogiwara, Keiji Nogami
Von Willebrand factor (VWF) and factor VIII (FVIII) complex play a pivotal role in hemostasis. A deficiency or defect of VWF causes von Willebrand disease (VWD). Recombinant (r)VWF product has proved to be effective for hemostatic treatment of VWD, but limited information is available on their role in moderating thrombus formation under flow condition. We aimed to assess thrombus formation in the presence
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Comparison between canine and porcine models of chronic deep venous thrombosis Thromb. J. (IF 3.1) Pub Date : 2023-12-06 Chuang Wang, Tao Tang, Sheng-Lin Ye, Nan Hu, Xiao-Long Du, Xiao-Qiang Li
To first induce chronic deep venous thrombosis in the left iliac veins of canines and porcines and then compare these two models to validate endovascular treatment devices. Thrombin and fibrinogen were used to produce a solid thrombus in the left iliac veins of a stenosis model. The researchers used venous angiography and histological staining to investigate the progression of thrombosis. A left iliac
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Factors associated with venous thromboembolic disease due to failed thromboprophylaxis Thromb. J. (IF 3.1) Pub Date : 2023-12-06 Santiago Grillo Pérez, Paula Ruiz-Talero, Oscar Mauricio Muñoz Velandia
Available evidence to identify factors independently associated with failed thromboprophylaxis (FT) in medical patients is insufficient. The present study seeks to evaluate in hospitalized patients, which clinical factors are associated with the development of FT. A case-control study nested to a historical cohort, comparing patients who developed failed thromboprophylaxis (cases) with those who did
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A comprehensive model for assessing and classifying patients with thrombotic microangiopathy: the TMA-INSIGHT score Thromb. J. (IF 3.1) Pub Date : 2023-11-22 Vanessa Vilani Addad, Lilian Monteiro Pereira Palma, Maria Helena Vaisbich, Abner Mácola Pacheco Barbosa, Naila Camila da Rocha, Marilia Mastrocolla de Almeida Cardoso, Juliana Tereza Coneglian de Almeida, Monica AP de Paula de Sordi, Juliana Machado-Rugolo, Lucas Frederico Arantes, Luis Gustavo Modelli de Andrade
Thrombotic Microangiopathy (TMA) is a syndrome characterized by the presence of anemia, thrombocytopenia and organ damage and has multiple etiologies. The primary aim is to develop an algorithm to classify TMA (TMA-INSIGHT score). This was a single-center retrospective cohort study including hospitalized patients with TMA at a single center. We included all consecutive patients diagnosed with TMA between
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Safety and efficacy of direct oral anticoagulants in stroke prevention in patients with atrial fibrillation complicated with anemia and/or thrombocytopenia: a retrospective cohort study Thromb. J. (IF 3.1) Pub Date : 2023-11-21 Wenlin Xu, Jiana Chen, Shuyi Wu, Nianxu Huang, Xia Chen, Wang Zhang, Wei Hu, Jun Su, Hengfen Dai, Ping Gu, Xiaohong Huang, Xiaoming Du, Ruijuan Li, Qiaowei Zheng, Xiangsheng Lin, Yanxia Zhang, Lang Zou, Yuxin Liu, Min Zhang, Xiumei Liu, Zhu Zhu, Jinhua Zhang
There are limited data about the clinical benefits and harm of direct oral anticoagulants (DOACs) in stroke prevention in patients with atrial fibrillation (AF) complicated with anemia or thrombocytopenia. This is a multi-center retrospective cohort study involving 5469 AF patients from 15 hospitals in China. Patients were divided into three groups according to hemoglobin and platelet levels: Group
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Superior sagittal sinus thrombosis in the course of mixed phenotype acute leukaemia treated with acute lymphoblastic leukaemia-like therapy—a case report Thromb. J. (IF 3.1) Pub Date : 2023-11-16 Wojciech Lizurej, Łukasz Mazurkiewicz, Michał Kowalski, Sylwia Szydłowska, Michał Wyrzykowski, Krzysztof Lewandowski
Mixed phenotype acute leukaemia (MPAL) is associated with worse overall survival, compared with other acute leukaemias in adults. Lack of clear treatment guidelines makes the therapy challenging. ALL-like induction and consolidation treatment followed by allo-HSCT is the preferred first-line treatment. We present a case of a 36-year-old woman diagnosed with MPAL (EGIL Myelo/B) with KMT2A rearrangement
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High-resolution magnetic resonance imaging-based radiomic features aid in selecting endovascular candidates among patients with cerebral venous sinus thrombosis Thromb. J. (IF 3.1) Pub Date : 2023-11-10 Yu-zhou Chang, Hao-Yu Zhu, Yu-Qi Song, Xu Tong, Xiao-Qing Li, Yi-Long Wang, Ke-Hui Dong, Chu-Han Jiang, Yu-Peng Zhang, Da-Peng Mo
Cerebral venous sinus thrombosis (CVST) can cause sinus obstruction and stenosis, with potentially fatal consequences. High-resolution magnetic resonance imaging (HRMRI) can diagnose CVST qualitatively, although quantitative screening methods are lacking for patients refractory to anticoagulation therapy and who may benefit from endovascular treatment (EVT). Thus, in this study, we used radiomic features
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Molecular patterns of alpha-thalassemia in the kingdom of Saudi Arabia: identification of prevalent genotypes and regions with high incidence Thromb. J. (IF 3.1) Pub Date : 2023-11-10 Hayaa M. Alhuthali, Eman F. Ataya, Alaa Alsalmi, Triq E Elmissbah, Khalaf F Alsharif, Hind A. Alzahrani, Ahad Amer Alsaiari, Mamdouh Allahyani, Amal F. Gharib, Husam Qanash, Heba M. Elmasry, Doha Elsayed Hassanein
Alpha-thalassemia (α-thalassemia) is one of the most common monogenic diseases in Saudi Arabia and is associated with significant morbidity. Premarital testing programs in Saudi Arabia reduce the burden of hemoglobinopathy disorders, and ongoing monitoring is required. We aimed to explore the molecular nature of α-globin genes and identify the most common genotypes and regions with a high risk of α-thalassemia
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A novel prognostic prediction indicator in patients with acute pulmonary embolism: Naples prognostic score Thromb. J. (IF 3.1) Pub Date : 2023-11-06 Ning Zhu, Shanhong Lin, Chao Cao
Acute pulmonary embolism (APE) is a potentially fatal disease. Early risk stratification is essential to determining appropriate treatment. We aimed to investigate the predictive value of the Naples Prognostic Score (NPS) for 30-day all-cause mortality in patients with APE. In this retrospective analysis, 325 hospitalized patients with APE were divided into Groups 0 (n = 131), 1 (n = 153), and 2 (n = 41)
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Arterial thrombosis triggered by methotrexate-induced hyperhomocysteinemia in a systemic lupus erythematosus patient with antiphospholipid antibodies Thromb. J. (IF 3.1) Pub Date : 2023-11-03 Chiara Schiavi, Luca Marri, Simone Negrini
Systemic lupus erythematosus (SLE) patients have an increased risk of cardiovascular disease and thrombotic events, and the presence of antiphospholipid antibodies further raises the risk of these complications. Here we report a case of a patient with SLE and triple positivity for antiphospholipid antibodies who developed a popliteal artery thrombosis in the context of a severe hyperhomocysteinemia
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The antithrombin activity recovery after substitution therapy is associated with improved 28-day mortality in patients with sepsis-associated disseminated intravascular coagulation Thromb. J. (IF 3.1) Pub Date : 2023-11-02 Toshiaki Iba, Tomoki Tanigawa, Hideo Wada, Jerrold H. Levy
Disseminated intravascular coagulation (DIC) is a common and critical complication in sepsis. Antithrombin activity, which is considered a biomarker for disease severity, was measured in septic DIC treated with antithrombin concentrates in this study. We conducted a retrospective analysis of post-marketing survey data that included 1,800 patients with sepsis-associated DIC and antithrombin activity
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Venous thromboembolic disease in admitted blunt trauma patients: what matters? Thromb. J. (IF 3.1) Pub Date : 2023-10-27 Camille Lineberry, Dimitri Alexis, Ambika Mukhi, Kevin Duh, Mathew Tharakan, James A. Vosswinkel, Randeep S. Jawa
Venous thromboembolic events (VTE) are a significant cause of morbidity and mortality following traumatic injury. We examined demographic characteristics, chemoprophylaxis, and outcomes of VTE patients with blunt trauma requiring hospitalization. A retrospective review of adult blunt trauma hospitalizations with and without VTE between 2012 and 2019 was conducted. Deaths in the emergency department
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The clinical application of venous ultrasound in diagnosis and follow-up of lower extremity deep vein thrombosis (DVT): a case-based discussion Thromb. J. (IF 3.1) Pub Date : 2023-10-26 Farooq Akram, Bingwen Eugene Fan, Chuen Wen Tan, Wey Chyi Teoh, Paolo Prandoni, Eng Soo Yap
Current clinical practice guidelines lack explicit guidance on the indications and appropriate timing of venous ultrasound (US) in lower extremity deep vein thrombosis (DVT) follow-up. Moreover, abnormal findings reported on venous US in DVT follow-up or suspected recurrent DVT may be difficult for clinicians to interpret, which carries risk of harm from inappropriate use of anti- coagulation and increased
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Causal inference of sex hormone-binding globulin on venous thromboembolism: evidence from Mendelian randomisation Thromb. J. (IF 3.1) Pub Date : 2023-10-25 Shuping Wang, Yongxiang Wang, Ming Bai, Yu Peng, Dan Zhou, Peng Lei, Binpeng Zhou, Piyi Zhang, Zheng Zhang
Previous cohort studies have shown that exogenous sex hormone use, such as testosterone replacement therapy and oestrogen-containing contraceptives, can increase the risk of venous thromboembolism (VTE). However, the relationship between endogenous sex hormone levels and VTE remains unclear. The goal of the present study was to explore the causal roles of endogenous sex hormones, including hormone-binding
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Robust preimplantation genetic testing of the common F8 Inv22 pathogenic variant of severe hemophilia A using a highly polymorphic multi-marker panel encompassing the paracentric inversion Thromb. J. (IF 3.1) Pub Date : 2023-10-20 Minh Tam Nguyen, Thanh Tung Nguyen, Duy Bac Nguyen, Thi Mai Nguyen, Kim Ngan Nguyen, Van Nhat Minh Ngo, Van Dieu Nguyen, Ngoc Anh Tran, Mulias Lian, Arnold S. C. Tan, Samuel S. Chong, Tien Truong Dang
Hemophilia A (HEMA) is an X-linked bleeding disorder caused by reduced/absent coagulation factor VIII expression, as a result of pathogenic variants in the F8 gene. Preimplantation prevention of HEMA should ideally include direct pathogenic F8 variant detection, complemented by linkage analysis of flanking markers to identify the high-risk F8 allele. Linkage analysis is particularly indispensable when
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The serum lipid profiles in immune thrombocytopenia: Mendelian randomization analysis and a retrospective study Thromb. J. (IF 3.1) Pub Date : 2023-10-13 Pengcheng Xu, Shouqing Han, Ming Hou, Yajing Zhao, Miao Xu
Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by increased platelet destruction and impaired thrombopoiesis. The changes in platelet indices depend on the morphology and volume of platelets. Serum lipids have been found to affect platelet formation and activity in certain diseases, thus inducing the corresponding variation of platelet indices. Mendelian randomization
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A prediction nomogram for deep venous thrombosis risk in patients undergoing primary total hip and knee arthroplasty: a retrospective study Thromb. J. (IF 3.1) Pub Date : 2023-10-12 Zhencan Lin, Hao Sun, Deng Li, Zhiqing Cai, Zhencheng Huang, Fangzhou Liu, Meiyi Chen, Yimin Wang, Jie Xu, Ruofan Ma
Deep venous thrombosis (DVT) prediction after total hip and knee arthroplasty remains challenging. Early diagnosis and treatment of DVT are crucial. This research aimed to develop a nomogram for early DVT prediction. A total of 317 patients undergoing primary total hip and knee arthroplasty in Sun Yat-sen Memorial Hospital were enrolled between May 2020 and September 2022. Data from May 2020 to February
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Development and validation of a new risk assessment model for immunomodulatory drug-associated venous thrombosis among Chinese patients with multiple myeloma Thromb. J. (IF 3.1) Pub Date : 2023-10-04 Xiaozhe Li, Xiuli Sun, Baijun Fang, Yun Leng, Fangfang Sun, Yaomei Wang, Qing Wang, Jie Jin, Min Yang, Bing Xu, Zhihong Fang, Lijuan Chen, Zhi Chen, Qimei Yang, Kejie Zhang, Yinhai Ye, Hui Geng, Zhiqiang Sun, Dan Hao, Hongming Huang, Xiaotao Wang, Hongmei Jing, Lan Ma, Xueyi Pan, Wenming Chen, Juan Li
Individuals with multiple myeloma (MM) receiving immunomodulatory drugs (IMiDs) are at risk of developing venous thromboembolism (VTE), a serious complication. There is no established clinical model for predicting VTE in the Chinese population. We develop a new risk assessment model (RAM) for IMiD-associated VTE in Chinese MM patients. We retrospectively selected 1334 consecutive MM patients receiving
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Sources of bias and limitations of thrombinography: inner filter effect and substrate depletion at the edge of failure algorithm Thromb. J. (IF 3.1) Pub Date : 2023-10-04 Joseph W. Jackson, Colin Longstaff, Samuel A. Woodle, William C. Chang, Mikhail V. Ovanesov
Fluorogenic thrombin generation (TG) is a global hemostasis assay that provides an overall representation of hemostasis potential. However, the accurate detection of thrombin activity in plasma may be affected by artifacts inherent to the assay-associated fluorogenic substrate. The significance of the fluorogenic artifacts or their corrections has not been studied in hemophilia treatment applications
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Evaluation of prothrombotic risk of two PROC hotspot mutations (Arg189Trp and Lys193del) in Chinese population: a retrospective study Thromb. J. (IF 3.1) Pub Date : 2023-10-03 Lei Li, Jian Li, Xi Wu, Wenman Wu, Qiulan Ding, Baohua Qian, Xuefeng Wang
R189W and K193del of protein C (PC) were hotspot mutations in Chinese population with venous thromboembolism (VTE), but almost two-thirds of patients with above mutations coexisting with other genetically or aquiredly prothrombotic risk factors. The aim of this study is to clarify the independent contributions of R189W or K193del to VTE risk. 490 unrelated patients with a personal history of VTE and
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Hyperlipidemia in immune thrombocytopenia: a retrospective study Thromb. J. (IF 3.1) Pub Date : 2023-10-02 Shouqing Han, Hui Lu, Yafei Yu, Xinguang Liu, Fangmiao Jing, Liang Wang, Yajing Zhao, Ming Hou
Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by low platelet count and bleeding manifestations. However, some patients also suffered from atherosclerosis or even infarction. Apart from activated platelets, lipid metabolism takes a large part in the formation of atherosclerosis and metabolic syndrome. The lipid metabolic state in ITP patients is still unknown. We
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A retrospective multicenter cohort study of the association between anti-Factor Xa values and death, thromboembolism, and bleeding in patients with critical COVID-19 Thromb. J. (IF 3.1) Pub Date : 2023-10-02 Sandra Jonmarker, Jacob Litorell, Felix Alarcon, Kais Al-Abani, Sofia Björkman, Maria Farm, Jonathan Grip, Mårten Söderberg, Jacob Hollenberg, Rebecka Rubenson Wahlin, Thomas Kander, Liivi Rimling, Johan Mårtensson, Eva Joelsson-Alm, Martin Dahlberg, Maria Cronhjort
Patients with critical COVID-19 have a high risk of thromboembolism, but intensified thromboprophylaxis has not been proven beneficial. The activity of low-molecular-weight heparins can be monitored by measuring anti-Factor Xa. We aimed to study the association between anti-Factor Xa values and death, thromboembolism, and bleeding in patients with critical COVID-19. This retrospective cohort study
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How to assess hypercoagulability in heparin-induced thrombocytopenia? Biomarkers of potential value to support therapeutic intensity of non-heparin anticoagulation Thromb. J. (IF 3.1) Pub Date : 2023-09-19 Antoine Barocas, Philippe Savard, Audrey Carlo, Thomas Lecompte, Emmanuel de Maistre
In case of heparin-induced thrombocytopenia (HIT), the switch to a non-heparin anticoagulant is mandatory, at a therapeutic dose. Such a treatment has limitations though, especially for patients with renal and/or hepatic failure. Candidate laboratory tests could detect the more coagulable HIT patients, for whom therapeutic anticoagulation would be the more justified. This was a monocentre observational
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Longitudinal trajectories of atherogenic index of plasma and risks of cardiovascular diseases: results from the Korean genome and epidemiology study Thromb. J. (IF 3.1) Pub Date : 2023-09-18 Dong-Wook Chun, Yae-Ji Lee, Jun-Hyuk Lee, Ji-Won Lee
Although the atherogenic index of plasma (AIP) based on a single measurement is a known risk factor for cardiovascular disease (CVD), little is known about whether changes in AIP over time are related to incident CVD. We aimed to determine whether AIP trajectory, which reflects homogenous AIP trends for a particular period, is associated with CVD risk. Data from 5,843 participants of the Korean Genome
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GDF15 affects venous thrombosis by promoting EndMT through smad2/p-smad2 pathway Thromb. J. (IF 3.1) Pub Date : 2023-09-18 Yeping Li, Huiqi Zhu, Wanghao Xin, Jiaoyan Wang, Chao Yan, Kejing Ying
Endothelial-to-mesenchymal transition (EndMT) is a pathophysiological change in the vascular endothelium commonly seen in the cardiovascular system. Elevated serum Growth differiention factor 15 (GDF15) has been reported in VTE patients, but the relationship and mechanism between GDF15, EndMT and VTE are still unclear. We performed a retrospective clinical study, and human serum GDF15 expression levels
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Lemierre’s syndrome complicating deep neck abscess: a case report Thromb. J. (IF 3.1) Pub Date : 2023-09-15 Yi Xu, Qingyuan Shi, Haiyue Ying
Lemierre’s Syndrome is a severe medical condition that can result from oropharyngeal infection, typically caused by Fusobacterium necrophorum, leading to sepsis, internal jugular vein thrombosis, and metastatic septic emboli. However, there is limited literature on this syndrome caused by Streptococcus anginosus, and few previous cases have been reported to have deep neck space infection. We present
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Assessing outcomes after thrombectomy with or without iliac vein stenting for young provoked DVT patients with iliac vein stenosis Thromb. J. (IF 3.1) Pub Date : 2023-09-15 Hongji Pu, Jumin Song, Zhijun He, Fuyin Wang, Jiateng Hu, Sheng Huang, Minyi Yin, Weimin Li, Xiaobing Liu, Xinwu Lu, Guang Liu
This study aimed to assess the outcomes of thrombectomy with/without iliac vein stenting for young and transiently provoked DVT patients with iliac vein stenosis. This is a retrospective analysis of a prospectively collected multicenter database. Acute, transiently provoked DVT patients between 18 and 45 years old with iliac vein stenosis were included. All patients underwent thrombectomy. Outcomes
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Early identification of lung cancer patients with venous thromboembolism: development and validation of a risk prediction model Thromb. J. (IF 3.1) Pub Date : 2023-09-14 Wenjuan Di, Haotian Xu, Chunhua Ling, Ting Xue
Venous thromboembolism(VTE) is a leading cause of death in patients with lung cancer. Furthermore, hospitalization of patients with advanced lung cancer for VTE treatment represents a major economic burden on the national public health resources. Therefore, we performed this prospective study to identify clinical biomarkers for the early identification of VTE in lung cancer patients. This prospective
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Tranexamic acid for haemostasis and beyond: does dose matter? Thromb. J. (IF 3.1) Pub Date : 2023-09-12 Tammy Lam, Robert L. Medcalf, Geoffrey C. Cloud, Paul S. Myles, Charithani B. Keragala
Tranexamic acid (TXA) is a widely used antifibrinolytic agent that has been used since the 1960’s to reduce blood loss in various conditions. TXA is a lysine analogue that competes for the lysine binding sites in plasminogen and tissue-type plasminogen activator impairing its interaction with the exposed lysine residues on the fibrin surface. The presence of TXA therefore, impairs the plasminogen and
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A case report of spontaneous pectoral hematoma in a male with background antiplatelet therapy after severe COVID-19 infection Thromb. J. (IF 3.1) Pub Date : 2023-09-07 Hao Tang, Yan Yan
Spontaneous muscle hematoma is a rare complication in hospitalized patients with COVID-19. We present a case of spontaneous pectoral hematoma occurring after COVID-19 infection and anticoagulation therapy. A 69-year-old male presented to the hospital with a two-week history of shortness of breath and a one-week history of high fever. Despite testing positive for COVID-19, the patient’s symptoms did
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Incidence of anti-platelet factor4/polyanionic antibodies, thrombocytopenia, and thrombosis after COVID-19 vaccination with ChAdOx1 nCoV-19 in Thais Thromb. J. (IF 3.1) Pub Date : 2023-09-06 Kochawan Boonyawat, Tichayapa Phojanasenee, Phichchapha Noikongdee, Pornnapa Police, Pichika Chantrathammachart, Pimjai Niparuck, Teeraya Puavilai, Angsana Phuphuakrat, Pantep Angchaisuksiri
The prevalence of anti-platelet factor 4 (PF4)/polyanionic antibodies occurring after vaccination with ChAdOx1 nCoV-19 is low. Most of these antibodies are not associated with vaccine-induced thrombotic thrombocytopenia. It remains unknown whether these antibodies are preexisting or occur as a result of vaccination. In this study, we demonstrated the incidence of anti-PF4/polyanionic antibodies, thrombocytopenia
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Damage-associated molecular patterns and fibrinolysis perturbation are associated with lethal outcomes in traumatic injury Thromb. J. (IF 3.1) Pub Date : 2023-09-06 Kenshin Shimono, Takashi Ito, Chinatsu Kamikokuryo, Shuhei Niiyama, Shingo Yamada, Hirokazu Onishi, Hideaki Yoshihara, Ikuro Maruyama, Yasuyuki Kakihana
Upon cellular injury, damage-associated molecular patterns (DAMPs) are released into the extracellular space and evoke proinflammatory and prothrombotic responses in animal models of sterile inflammation. However, in clinical settings, the dynamics of DAMP levels after trauma and links between DAMPs and trauma-associated coagulopathy remain largely undetermined. Thirty-one patients with severe trauma