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Utility of bioelectrical phase angle for cardiovascular risk assessment among individuals with and without diabetes mellitus Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2024-02-02 Dimitrios Tsilingiris, Lukas Schimpfle, Zoltan Κender, Alba Sulaj, Ekaterina von Rauchhaupt, Stephan Herzig, Julia Szendroedi, Stefan Kopf
PurposeLow values of bioimpedance-derived phase angle (PA) have been associated with various adverse outcomes. We investigated the association of PA with cardiovascular markers in individuals with and without diabetes mellitus (DM).MethodsPA was measured in 452 adults (without DM n = 153, T1DM n = 67, T2DM n = 232). Carotid intima-media thickness (IMT), renal resistive index (RRI), ankle-brachial index
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Effects of co-supplementation of chromium and magnesium on metabolic profiles, inflammation, and oxidative stress in impaired glucose tolerance Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2024-01-17 Yang Zhao, Mengmeng Zhou, Yongfang Shang, Mei Dou, Shan Gao, Hai Yang, Fanghua Zhang
PurposeTo evaluate the effects of chromium (Cr) and magnesium (Mg) ions on metabolic profiles, inflammation, and oxidative stress with impaired glucose tolerance (IGT) and insulin resistance (IR).Methods120 individuals with IGT and IR were randomly divided into four groups treated with (1) chromium, (2) magnesium, (3) chromium and magnesium or (4) placebo. Metabolic and inflammatory indicators were
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Comparative study of microvascular structural changes in the gestational diabetic placenta Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-05-15 Xinyan Liang, Jiaqi Zhang, Yu Wang, You Wu, Hui Liu, Wei Feng, Ziyi Si, Ruige Sun, Zizhou Hao, Hongzhi Guo, Xue Li, Tao Xu, Mofeng Wang, Zhen Nan, Yang Lv, Xinan Shang
AimsMicrovascular morphology and pathological changes in gestational diabetes mellitus (GDM) placentas and normal placentas were observed via vascular casting technology, electron microscopy, and p...
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Restoration of coronary microvascular function by OGA overexpression in a high-fat diet with low-dose streptozotocin-induced type 2 diabetic mice Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-05-15 Jody Tori Cabrera, Rui Si, Atsumi Tsuji-Hosokawa, Hua Cai, Jason X-J Yuan, Wolfgang H Dillmann, Ayako Makino
Sustained hyperglycemia results in excess protein O-GlcNAcylation, leading to vascular complications in diabetes. This study aims to investigate the role of O-GlcNAcylation in the progression of co...
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“Arterial stiffness is not associated with changes in the circadian pattern of blood pressure in patients with type 1 diabetes mellitus and cardiovascular autonomic dysfunction” Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-05-15 Lía Nattero-Chávez, Ane Bayona Cebada, Elena Fernández-Durán, Alejandra Quintero Tobar, Beatriz Dorado Avendaño, Héctor Escobar-Morreale, Manuel Luque-Ramírez
IntroductionCardiovascular autonomic neuropathy (CAN) associates an abnormal circadian pattern in blood pressure (BP) regulation that might be aggravated by the coexistence of arterial stiffness. W...
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Improved extremity tissue oxygenation with short-term exposure to textiles embedded with far infrared light emitting thermoactive particles in patients with diabetes mellitus Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-04-18 Diana Athonvarangkul, Kaicheng Wang, Yanhong Deng, Silvio E Inzucchi, Adam Mayerson
Use of far infrared (FIR) energy may improve peripheral circulation. This study aimed to determine whether FIR delivered through textiles improves peripheral microcirculation as measured by transcu...
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High serum Bhlhe40 levels are associated with subclinical atherosclerosis in patients with type 2 diabetes mellitus: A cross-sectional study Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-03-29 Hui Xu, Qun-Yan Xiang, Shuang Li, You-Shuo Liu
BackgroundOur previous studies have shown that the basic helix-loop-helix family member e40 (Bhlhe40) plays a critical role in regulating calcification and senescence of vascular smooth muscle cell...
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Disruption of COMMD1 accelerates diabetic atherosclerosis by promoting glycolysis Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-02-19 Lili Zhang, Lihua Li, Yalan Li, Han Jiang, Zhen Sun, Guangyao Zang, Yongjiang Qian, Chen Shao, Zhongqun Wang
AimsDiabetes will lead to serious complications, of which atherosclerosis is the most dangerous. This study aimed to explore the mechanisms of diabetic atherosclerosis.MethodsApoE−/− mice were fed ...
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Real-world study of flash glucose monitoring among adults with type 2 diabetes within the Swedish National Diabetes Register Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-30 Katarina Eeg-Olofsson, Ann-Marie Svensson, Stefan Franzén, Hodan Ahmed Ismail, Michael Törnblom, Fleur Levrat-Guillen
BackgroundThe Swedish National Diabetes Register (NDR) initiated registration of the FreeStyle Libre® system and other continuous glucose monitoring (CGM) systems in June 2016. We investigated chan...
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Temporal trends in minor and major lower extremity amputation in people with type 2 diabetes: The Fremantle Diabetes Study Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-30 Emma J Hamilton, Wendy A Davis, Mendel Baba, Timothy ME Davis
AimsTo determine whether incident minor and major lower extremity amputations (LEAs) have declined in recent decades in type 2 diabetes.MethodsParticipants with type 2 diabetes from the community-b...
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Responses of retinal and brain microvasculature to streptozotocin induced diabetes revealed by global expression profiling Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-06 Youhai Li, Alen Faiz, Han Moshage, Lothar Schilling, Jan AAM Kamps
This study aims to determine the effects of diabetes in the retinal and brain microvasculature through gene expression profiling. Twelve male Wistar rats were randomly divided into two groups: stre...
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Lipoprotein (a) as a predictor of diabetic retinopathy in patients with type 2 diabetes: A systematic review. Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-01 Mohammad Sadra Gholami Chahkand,Fatemeh Esmaeilpour Moallem,Abolfazl Qezelgachi,Kiana Seifouri,Armin Pesaran Afsharian,Farzad Sheikhzadeh,Atefe Poursalehi,Fateme Sadat Fani Sadrabadi,Mehrnush Saghab Torbati,Mohaddese Ramezanzade,Goharsharieh Alishiri,Arina Ansari,Emad Zare Dehabadi,Saeed Karimi Matloub,Zahra Sheikh,Niloofar Deravi,Saba Mehrtabar,Fatemeh Chichagi,Neda Faal Hamedanchi,Mohammadreza Arzaghi
BACKGROUND Lipoprotein a (LP(a)), an LDL-like lipoprotein, known as a risk factor for cardiovascular diseases, has a controversial association with diabetic retinopathy in patients with type 2 diabetes-the current systematic review aimed to critically assess the association between LP(a) and diabetic retinopathy. METHODS A systematic review of relevant studies was conducted after a thorough search
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Optimizing statin therapy for primary prevention of cardiovascular disease in type 2 diabetes mellitus patients: Exploring dose, class, and intensity. Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-01 Jung-Min Yu,Wan-Ming Chen,Ben-Chang Shia,Szu-Yuan Wu
PURPOSE To investigate the impact of statin use on primary prevention of cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (T2DM) in a dose-, class-, and use intensity-dependent manner. METHODS We used an inverse probability treatment-weighted Cox hazards model, with statin use status as a time-dependent variable. RESULTS Our results showed that statin use was associated with a
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Association of diabetes with coronary artery calcium in South Asian adults and other race/ethnic groups: The multi-ethnic study of atherosclerosis and the mediators of atherosclerosis in South Asians living in America study. Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-01 Ned Premyodhin,Wenjun Fan,Millie Arora,Matthew J Budoff,Alka M Kanaya,Namratha Kandula,Latha Palaniappan,Jamal S Rana,Masood Younus,Nathan D Wong
PURPOSE South Asian (SA) persons have increased risks for diabetes mellitus (DM) and atherosclerotic cardiovascular disease (ASCVD). We examined whether the association of DM with subclinical atherosclerosis assessed by coronary artery calcium (CAC) differs in SA versus other ethnic groups. METHODS We studied adults from the Multi-Ethnic Study of Atherosclerosis and the Mediators of Atherosclerosis
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Advanced glycation end products impair coronary artery BK channels via AMPK/Akt/FBXO32 signaling pathway. Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-01 Xiao-Yan Li,Ling-Ling Qian,Ying Wu,Yu-Min Zhang,Shi-Peng Dang,Xiao-Yu Liu,Xu Tang,Cun-Yu Lu,Ru-Xing Wang
Background: Advanced glycation end products (AGEs) impair vascular physiology in Diabetes mellitus (DM). However, the underlying mechanisms remain unclear. Vascular large conductance calcium-activated potassium (BK) channels play important roles in coronary arterial function.Purpose: Our study aimed to investigate the regulatory role of AGEs in BK channels.Research Design: Using gavage of vehicle (V
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Dapagliflozin attenuates cardiac remodeling and dysfunction in rats with β-adrenergic receptor overactivation through restoring calcium handling and suppressing cardiomyocyte apoptosis. Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-01 Tao Liu,Jinchun Wu,Shaobo Shi,Bo Cui,Feng Xiong,Shuang Yang,Min Yan
Background: Long-term β-adrenergic receptor (β-AR) activation can impair myocardial structure and function. Dapagliflozin (DAPA) has been reported to improve clinical prognosis in heart failure patients, whereas the exact mechanism remains unclear. Here, we investigated the effects of DAPA against β-AR overactivation toxicity and explored the underlying mechanism.Methods and Results: Rats were randomized
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Association of hemoglobin glycation index with prognosis of coronary artery disease after percutaneous coronary intervention: A retrospective cohort study. Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-01 Meng-Die Cheng,Jun-Nan Tang,Zhi-Yu Liu,Qian-Qian Guo,Jian-Chao Zhang,Zeng-Lei Zhang,Feng-Hua Song,Kai Wang,Li-Zhu Jiang,Lei Fan,Xiao-Ting Yue,Yan Bai,Xin-Ya Dai,Ru-Jie Zheng,Ying-Ying Zheng,Jin-Ying Zhang
AIMS To analyze the association between hemoglobin glycation index (HGI) and the long-term prognosis of patients with coronary artery disease (CAD) after percutaneous coronary intervention (PCI). METHODS Predicted glycated hemoglobin (HbA1c) level was calculated using an established formula and HGI represented the difference between laboratory measured HbA1c and predicted HbA1c. A total of 1780 patients
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Trends in cardiovascular burden and mortality among adults with prediabetes in the US, 1999-2018. Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-01 Yi Zhang,Ruodi Lu,Jian Wang,Xingjian Zhang,Xiao Ma
BACKGROUND Trends in cardiovascular disease (CVD) risk factors and mortality have been reported among US adults with diabetes, but not among those with prediabetes. This study aimed to examine and compare the trends in CVD risk factors and mortality in US adults with diabetes and prediabetes. METHODS In this serial, cross-sectional study, medical records of prediabetic patients from the National Health
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Management of diabetic neuropathy with memantine: A randomized clinical trial. Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-01 Elnaz Jafarzadeh,Samineh Beheshtirouy,Nasser Aghamohammadzadeh,Saba Ghaffary,Parvin Sarbakhsh,Elnaz Shaseb
BACKGROUND Diabetes patients frequently experience diabetic neuropathy (DN), a microvascular complication that significantly reduces patients' quality of life. Memantine has demonstrated potential benefits for neuropathic pains in preclinical studies. This study aimed to assess the efficacy of memantine in the management of peripheral neuropathy in patients with type 2 diabetes mellitus (T2DM). METHOD
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Comparison of fetal and neonatal cardiac morphology between the infants of mothers with well-controlled gestational diabetes mellitus and normal controls. Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-01 Phenphan Santanapipatkul,Suchaya Luewan,Rekwan Sittiwangkul,Nopparat Krongphaiklang,Phudit Jatavan,Theera Tongsong
OBJECTIVE To compare fetal and neonatal cardiac morphology in fetuses of mothers with gestational diabetes mellitus (GDM) with the controls. PATIENTS AND METHODS Pregnant women at average risk of GDM underwent 100-g, 3-h-OGTT at 24-28 weeks of gestation for diagnosis of GDM. Both GDM group and the control group underwent fetal echocardiography at 32-36 weeks to assess cardiac dimensions. The neonates
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Mid-term safety and efficacy of magnesium bioresorbable vascular scaffolds - magmaris in diabetic population. 2-Years outcome in acute coronary syndrome cohort. Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-01 Adrian Włodarczak,Piotr Rola,Mateusz Barycki,Łukasz Furtan,Magdalena Łanocha,Szymon Włodarczak,Marek Szudrowicz,Jan Jakub Kulczycki,Joanna Jaroszewska-Pozorska,Michalina Kędzierska,Katarzyna Giniewicz,Adrian Doroszko,Maciej Lesiak
BACKGROUND Diabetes type 2 is one of the strongest risk factors affecting coronary artery disease (CAD) and is also a marker of poor short and long-term prognosis in subjects with acute coronary syndrome (ACS) treated with percutaneous coronary intervention (PCI) with subsequent drug-eluting stent (DES) implantation. Chronic local vascular inflammation along with endothelial dysfunction is postulated
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Cardiometabolic risk factors, peripheral arterial tonometry and metformin in adults with type 1 diabetes participating in the REducing with MetfOrmin Vascular Adverse Lesions trial. Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-01 David Chen,Alicia J Jenkins,Nicola Greenlaw,Katie Dudman,Tamsin Fernandes,David M Carty,Alun D Hughes,Andrzej S Januszewski,Coen DA Stehouwer,John R Petrie
BACKGROUND Peripheral arterial tonometry (PAT) provides non-invasive measures of vascular health. Beneficial effects of metformin on vascular function have been reported in youth with type 1 diabetes (T1D). In the REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL) trial in adults with T1D and high cardiovascular risk, we examined: (i) the extent to which routinely-measured cardiometabolic risk
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Can prediabetes diagnosed using HemoglobinA1c or oral glucose tolerance test predict presence and severity of coronary artery disease in symptomatic patients? Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-01 Katrine S Overgaard,Thomas R Andersen,Roda A Mohamed,Laurits J Heinsen,Helle G Binderup,Sören Möller,Søren Auscher,Jess Lambrechtsen,Kenneth Egstrup
We investigated whether prediabetes diagnosed by hemoglobinA1c (HbA1c) or oral glucose tolerance test (OGTT) could predict presence and severity of coronary artery disease (CAD) in symptomatic patients. The presence of plaque, stenosis, plaque characteristics, and coronary artery calcium (CAC) were evaluated by coronary CT angiography in 702 patients with suspicion of CAD. Patients were classified
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Glycemic control and outcome after carotid intervention in patients with T2D: A Swedish nationwide cohort study. Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-01 Alexander Zabala,Anders Gottsäter,Marcus Lind,Björn Eliasson,Rebecka Bertilsson,Jan Ekelund,Magnus Jonsson,Thomas Nyström
AIMS To investigate the association between glycemic control and outcome in people with type 2 diabetes (T2D) after carotid intervention due to carotid stenosis. METHODS Observational nationwide population-based cohort study using inverse probability treatment weighting (IPTW) and Cox regressions with covariates, that is, 4 stepwise models, investigating the relationship between terciles of glycated
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Health care registers can be instrumental for endpoint capture in clinical diabetes trials: example of microvascular complications in Swedish patients with type 2 diabetes. Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-01 Martin H Lundqvist,Vagia Patsoukaki,Stefan Jansson,Henrietta Norman,Elisabet Granstam,Maria K Svensson,Johan Sundström,Björn Eliasson,Jan W Eriksson
AIMS SMARTEST is a register-based randomized clinical trial (RRCT) that compares dapagliflozin to metformin in early-stage type 2 diabetes. The primary outcome includes progression of microvascular complications based on data from the Swedish National Diabetes Register (NDR). In this sub-study, the aim was to validate microvascular complication variables in the NDR against electronic health records
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Trends in metabolic indicators and microvascular complications in Chinese adults with newly diagnosed type 2 diabetes: A retrospective, single-centre study of twenty-years. Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-01 Lintao Shi,Jing Xue,Weibo Zhao,Yuxia Cheng,Jianjun Wang,Zhangrong Xu,Aihong Wang
BACKGROUND The purpose of this study is to assess metabolic indicators and trends in microvascular complications among Chinese adults with newly diagnosed type 2 diabetes during 2000-2020. METHODS 3,907 patients were included and divided into three groups according to a time period of 7 years. This study analyzed trends in proportions of patients reached therapeutic targets of blood glucose, pressure
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TyG-BMI and hypertension in Normoglycemia subjects in Japan: A cross-sectional study. Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-01 Xinming Huang,Jiacheng He,Guoxin Wu,Zishu Peng,Bin Yang,Langxi Ye
BACKGROUND Insulin Resistance (IR) are associated with Hypertension (HTN). Triglyceride glucose-body mass index (TyG-BMI) is a readily available and clinically significant indicator of IR. This study aimed to investigate whether TyG-BMI is independently associated with HTN. METHODS A total of 15,464 patients with normal blood glucose from 2004 to 2016 participated in this study. Participants were divided
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miR-1187 induces podocyte injury and diabetic nephropathy through autophagy. Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2023-01-01 Bin Chen,Qiang He
MicroRNAs plays important roles in the progression of diabetic nephropathy (DN) and podocyte injury. This study aimed to investigate the role and regulation mechanism of miR-1187 during the development of DN and podocyte injury. The content of miR-1187 in podocytes was up-regulated under high glucose (HG) treatment and increased in kidney tissue of db/db mice (DN model mice) compared with control db/m
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Intermittently scanned continuous glucose monitoring is associated with lower spontaneous abortion rate compared with conventional blood glucose monitoring in pregnant women with type 1 diabetes: An observational study Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-12-14 Madleen Lemaitre, Kenza Faiz, Florence Baudoux, Damien Subtil, Anne Vambergue
AimThe objective of the present real-life study in France was to assess and compare characteristics and outcomes in a cohort of pregnant women with type 1 diabetes (T1D) using intermittently scanne...
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Ten-year incidence of post-transplant Diabetes Mellitus in renal transplant patients Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-12-05 Fatemeh Habibnia, Farshid Oliaei, Hoda Shirafkan, Mobarakeh Abbasi Firoozjah, Mobina Rezaei Roshan, Roghayeh Akbari
BackgroundKidney transplantation is the treatment of choice for renal failure. Development of New-Onset Diabetes After Transplantation (NODAT) significantly increases kidney graft loss and mortalit...
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C1q/TNF-related protein-2 improved angiogenesis to protect myocardial function during ischaemia‒reperfusion Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-11-21 Mingfang Ye, Qi-Hong Wu, Ke Yang, Yukun Luo
BackgroundCollateral growth plays an important role in the recovery of acute myocardial infarction. C1q/TNF-related protein-2 (CTRP2), a CTRP family member, showed some protective effects on cell s...
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Monitoring and recovery of hyperglycaemia-induced endothelial dysfunction with rheopheresis in diabetic lower extremity ulceration with hyperviscosity Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-11-10 Kristóf Gál, Georgina Asbóth, Melinda Vass, Attila Bíró, Arnold Markovich, Judit Homoki, Gábor Fidler, Melinda Paholcsek, Zoltán Cziáky, Norbert Németh, Judit Remenyik, Pál Soltész
AimsRheopheresis is an extracorporeal haematotherapy that improves haemorheological status by filtering proteins that enhance blood viscosity. It also has anti-inflammatory effects by removing infl...
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Glycaemic variability and risk of adverse cardiovascular events in acute coronary syndrome Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-11-05 Lei Zhang, Feng Li, Huan-Huan Liu, Zhi-Yuan Zhang, Fan Yang, Ling-Ling Qian, Ru-Xing Wang
ObjectiveThe relationship between different glycaemic variability (GV) indexes and adverse cardiovascular outcomes is not well understood. This study aims to determine whether GV is related to the ...
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Triglyceride glucose index is independently associated with aortic intima-media thickness in patients without known atherosclerotic cardiovascular disease or diabetes Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-10-21 Süleyman ÖZBİÇER, Gülhan YÜKSEL, Örsan Deniz URGUN
Background: The triglyceride-glucose (TyG) index is a reliable marker of insulin resistance. We aimed to investigate the relationship between the TyG index and aortic intima-media thickness (IMT) i...
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Real life evaluation of sodium-glucose cotransporter 2 inhibition in type 1 diabetes and the risk of diabetic ketoacidosis Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-10-19 Elisabeth B Stougaard, Peter L Kristensen, Urd Kielgast, Henrik U Andersen, Yasmin Hamid, Peter H Gæde, Esben Søndergaard, Gry H Dørflinger, Karen K Fjeldborg, Klavs W Hansen, Henrik H Thomsen, Thuraya M.J. Al-Imar, Michael Røder, Vikas S Sridhar, David Cherney, Peter Rossing, Frederik Persson
BackgroundThe indication for treatment of type 1 diabetes(T1D) with the sodium–glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin has been withdrawn in Europe likely because of concern for di...
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Impact of diabetes on outcomes of cardiogenic shock: A systematic review and meta-analysis Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-10-17 Chao Luo, Feng Chen, Lingpei Liu, Zuanmin Ge, Chengzhen Feng, Yuehua Chen
To provide synthesized evidence on the association of diabetes with clinical outcomes of patients with acute myocardial infarction (AMI) and associated cardiogenic shock (CS). We analyzed observati...
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Mitochondrial mitophagy protection combining rivaroxaban and aspirin in high glucose-exposed human coronary artery endothelial cell. An in vitro study Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-10-16 Khaoula Zekri-Nechar, José Javier Zamorano-León, Mercedes Cortina-Gredilla, Ana López-de-Andrés, Rodrigo Jiménez-García, Carlos Navarro-Cuellar, Antonio López-Farré, Carlos Hugo Martínez-Martínez
PurposeCombination of Rivaroxaban plus Aspirin improved cardiovascular outcome in patients with stable cardiovascular disease. The aim was to determine if Rivaroxaban and acetylsalicylic acid alone...
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Coronary artery calcium score and coronary computed tomography angiography predict one-year mortality in patients with type 2 diabetes and peripheral artery disease undergoing partial foot amputation Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-10-12 Evgeniya Shalaeva, Arjola Bano, Ulugbek Kasimov, Bakhtiyor Janabaev, Iris Baumgartner, Markus Laimer, Hugo Saner
The aim of the study was to examine the predictive value of coronary computed tomographic angiography (CCTA) and coronary artery calcium score (CACS) on 1-year all-cause mortality in type 2 diabete...
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Epicardial adipose tissue and right ventricular function in type 2 diabetes mellitus using two-dimensional speckle tracking echocardiography Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-08-23 Xiang-ting Song, Ping-yang Zhang, Li Fan, Yi-fei Rui
BackgroundEpicardial adipose tissue is an emerging cardiovascular risk factor. The aim of this study was to evaluate right ventricular function and investigate its association with EAT in T2DM pati...
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Shared and specific biological signalling pathways for diabetic retinopathy, peripheral neuropathy and nephropathy by high-throughput sequencing analysis Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-08-21 Hui Zhu, Yan-ming Chen, Wei-kun Gong, Jing-bo Lai, Bin-bin Yao, Zhi-jia Zhao, Qin-kang Lu, Ke Ye, Lin-dan Ji, Jin Xu
ObjectivesWe aimed to explore the shared and specific signalling pathways involved in diabetic retinopathy (DR), diabetic peripheral neuropathy (DPN) and diabetic nephropathy (DN).MethodsDifferenti...
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Hyperinsulinemia alters insulin receptor presentation and internalization in brain microvascular endothelial cells Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-08-16 Luke S Watson, Brynna Wilken-Resman, Alexus Williams, Stephanie DiLucia, Guadalupe Sanchez, Taylor L McLeod, Catrina Sims-Robinson
Insulin receptors are internalized by endothelial cells to facilitate their physiological processes; however, the impact of hyperinsulinemia in brain endothelial cells is not known. Thus, the aim o...
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Cardiovascular risk factors, exercise capacity and health literacy in patients with chronic ischaemic heart disease and type 2 diabetes mellitus in Germany: Baseline characteristics of the Lifestyle Intervention in Chronic Ischaemic Heart Disease and Type 2 Diabetes study Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-08-11 Sophia MT Dinges, Janosch Krotz, Felix Gass, Julian Treitschke, Isabel Fegers-Wustrow, Marisa Geisberger, Katrin Esefeld, Pia von Korn, André Duvinage, Frank Edelmann, Oliver Wolfram, Julia Brandts, Ephraim B Winzer, Bernd Wolfarth, Felix Freigang, Sarah Neubauer, Thomas Nebling, Björn Hackenberg, Volker Amelung, Stephan Mueller, Martin Halle
Background:Lifestyle interventions are a cornerstone in the treatment of chronic ischaemic heart disease (CIHD) and type 2 diabetes mellitus (T2DM). This study aimed at identifying differences in c...
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Triglyceride-glucose index is prospectively associated with chronic kidney disease progression in Type 2 diabetes – mediation by pigment epithelium-derived factor Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-08-08 Serena Low, Sharon Pek, Angela Moh, Keven Ang, Jonathon Khoo, Yi-Ming Shao, Wern E Tang, Ziliang Lim, Tavintharan Subramaniam, Chee F Sum, Su C Lim
BackgroundTriglyceride-glucose (TyG) index is a surrogate marker of insulin resistance. Its role in chronic kidney disease (CKD) progression in Type 2 Diabetes Mellitus (T2DM) is unclear. We invest...
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Impact of diabetes on long-term all-cause re-hospitalization after revascularization with percutaneous coronary intervention Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-07-21 Kirstine N Hansen, Manijeh Noori, Evald H Christiansen, Eskild B Kristiansen, Michael Maeng, Ann Dorthe O Zwisler, Britt Borregaard, Rikke Søgaard, Karsten T Veien, Anders Junker, Lisette Okkels Jensen
Purpose:The purpose of the study was to investigate the incidence, cause and probability of re-hospitalization within 30 and 365 days after percutaneous coronary intervention (PCI) in patients with...
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Accounting for concurrent antihyperglycemic medication changes in dietary and physical activity interventions: A focused literature review Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-06-24 Dennis B Campbell, Dana Lee Olstad, Teagan Donald, David JT Campbell
AimsTo summarize methods used to account for antihyperglycemic medication changes in randomized controlled trials evaluating the effect of dietary and physical activity interventions on glycemia am...
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Impact of COVID-19 therapy on hyperglycemia Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-06-13 Rachel Parise, Jack Deruiter, Jun Ren, Manoj Govindarajulu, Sindhu Ramesh, Rishi M Nadar, Timothy Moore, Muralikrishnan Dhanasekaran
The goal of this study was to analyze the effect of COVID-19 drugs and biologicals on hyperglycemia. A literature search with key terms, such as “COVID-19 drugs and hyperglycemia” and “COVID-19 vac...
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Hypoglycemic agents and glycemic variability in individuals with type 2 diabetes: A systematic review and network meta-analysis Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-06-10 SuA Oh, Sujata Purja, Hocheol Shin, Minji Kim, Eunyoung Kim
While hemoglobin A1c (HbA1c) is commonly used to monitor therapy response in type 2 diabetes (T2D), GV is emerging as an essential additional metric for optimizing glycemic control. Our goal was to...
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Glucose variability is associated with an adverse vascular profile but only in the presence of insulin resistance in individuals with type 1 diabetes: An observational study Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-06-03 Noppadol Kietsiriroje, Sam M Pearson, Lauren L O’Mahoney, Daniel J West, Robert AS Ariëns, Ramzi A Ajjan, Matthew D Campbell
Aims/HypothesisWe hypothesised that the detrimental effect of high glucose variability (GV) in people with type 1 diabetes is mainly evident in those with concomitant insulin resistance.MethodsWe c...
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Sleep behaviours and associated habits and the progression of pre-diabetes to type 2 diabetes mellitus in adults: A systematic review and meta-analysis Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-05-26 Samiul A Mostafa, Sandra Campos Mena, Christina Antza, George Balanos, Krishnarajah Nirantharakumar, Abd A Tahrani
Introduction Certain sleep behaviours increase risk of type 2 diabetes mellitus (T2DM) in the general population, but whether they contribute to the progression from pre-diabetes to T2DM is uncertain. We conducted a systematic review to assess this. Methods Structured searches were performed on bibliographic databases (MEDLINE, EMBASE and CINAHL) from inception to 26/04/2021 for longitudinal studies/trials
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Plasma proteomics reveals an improved cardio-metabolic profile in patients with type 2 diabetes post-liraglutide treatment Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-05-26 Aishah A Ekhzaimy, Afshan Masood, Hicham Benabdelkamel, Tasnem Elhassan, Mohthash Musambil, Assim A Alfadda
Background Diabetes mellitus is a chronic multisystem disease with a high global prevalence, including in Saudi Arabia. The Glucagon-like Peptide (GLP-1) receptor agonist liraglutide is known to lower glucose levels, reduce weight and improve cardiovascular outcome. However, mechanisms underlying the benefits of liraglutide treatment in patients with type 2 diabetes mellitus (T2DM) remain unclear.
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Ultra-high frequency ultrasound delineated changes in carotid and muscular artery intima-media and adventitia thickness in obese early middle-aged women Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-05-30 Johnny KM Sundholm, Linda Litwin, Kristiina Rönö, Saila B Koivusalo, Johan G Eriksson, Taisto Sarkola
Obesity is linked to increased arterial size, carotid intima-media thickness and arterial stiffness. The effects of obesity and body composition on muscular artery intima-media and adventitia thickness has previously not been established. The aim of this study was to explore associations between carotid and muscular artery wall layer thickness with body composition and cardiovascular risk factors in
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The association between sodium-glucose cotransporter 2 inhibitors and incident dementia: A nationwide population-based longitudinal cohort study Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-05-12 Wun-Zhih Siao, Tsung-Kun Lin, Jing-Yang Huang, Chin-Feng Tsai, Gwo-Ping Jong
BackgroundThe association of the use of sodium-glucose cotransporter 2 (SGLT2) inhibitor and incident dementia remains unclear. This study aimed to evaluate the risk of incident dementia with the use of SGLT2 inhibitor.MethodsThis is a population-based cohort study utilizing Taiwan’s National Health Insurance Research Database. Each patient who took SGLT2 inhibitors was assigned to the SGLT2 inhibitor
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Glucolipotoxicity induces endothelial cell dysfunction by activating autophagy and inhibiting autophagic flow Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-05-12 Yulan Liu, Hong Xiang, Wenfang Xiong, Jie Ouyang, Hengdao Liu, Shaoli Zhao, Jie Xiao, Jialing Li, Zhihao Shu, Xuewen Wang, Huiqin Liu, Jing Zhang, Jianing Fan, Ying Li, Shuhua Chen, Hongwei Lu
ObjectivesThis study aims to determine the role and mechanism of autophagy in endothelial cell dysfunction by glucolipotoxicity.MethodsHuman umbilical vein endothelial cells (HUVECs) were treated with high glucose and high palmitic acid. The number of autophagosomes was evaluated by monodansylcadaverine (MDC) staining and transmission electron microscopy (TEM). The expression of autophagy-related proteins
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Impact of insulin therapy on outcomes of diabetic patients with heart failure: A systematic review and meta-analysis Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-05-11 Jingxing Liu, Xinhua Hu
Objective:To compare clinical outcomes in diabetic patients with heart failure managed by insulin with those managed by non-insulin (oral hypoglycemic agents and/or lifestyle modification) based therapy.Methods:PubMed and Scopus databases were searched for studies conducted on diabetic patients with heart failure. Studies were to compare outcomes of patients managed by insulin versus non-insulin therapies
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Diabetic nephropathy ameliorated in patients with normal home blood pressure compared to those with isolated high home systolic blood pressure: A 5-year prospective cohort study among patients with type 2 diabetes mellitus Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-05-10 Nobuko Kitagawa, Emi Ushigome, Noriyuki Kitagawa, Hidetaka Ushigome, Isao Yokota, Naoko Nakanishi, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Michiaki Fukui
Background:Using normal home blood pressure (home BP) as a reference, isolated high home systolic blood pressure (IH-home SBP) increases the risk of diabetic nephropathy. However, whether diabetic nephropathy would improve among diabetic patients without IH-home SBP has not been previously assessed.Methods:This prospective 5-year cohort study of 264 patients with moderate or severe albuminuria investigated
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Extracellular vesicles in gestational diabetes mellitus: A scoping review Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-04-08 Tanvi Bathla, Akram Abolbaghaei, Agafe Bless Reyes, Dylan Burger
Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy worldwide. Despite extensive study, the molecular mechanisms leading to GDM and associated perinatal complications are not well understood. The condition is also associated with an increased risk of future cardiometabolic disease in both mothers and their offspring. Thus, there is a pressing need for the development
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Function outperforms morphology in the assessment of muscular contribution to insulin sensitivity in premenopausal women Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-03-31 Lorena Wanger, Christina Gar, Michaela Rippl, Stefanie Kern-Matschilles, Anne Potzel, Stefanie Haschka, Jochen Seissler, Nina Hesse, Andreas Lechner
Introduction Skeletal muscle contributes significantly to insulin sensitivity in humans. However, which non-invasive measurement best reflects this contribution remains unknown. Consequently, this paper compares morphologic and functional measurements. Research methods and design We conducted a cross-sectional analysis of 144 premenopausal women enrolled in the “Prediction, Prevention, and Sub-classification
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Association of triglyceride-glucose with cardiac hemodynamics in type 2 diabetes Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-03-29 Chenxi Wang, Zhicong Zhao, Xia Deng, Zhensheng Cai, Tian Gu, Lian Li, Chang Guo, Dong Wang, Ling Yang, Li Zhao, Guoyue Yuan
Purpose Triglyceride-glucose (TyG) index is a reliable and inexpensive alternative indicator of insulin resistance. Previous studies have shown that elevated TyG index increases the risk of diabetes, coronary heart disease, and other diseases, but the relationship between TyG index and cardiac hemodynamics in patients with type 2 diabetes mellitus (T2DM) is not clear. This study was conducted in patients
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Plasma advanced glycation end products and soluble receptor for advanced glycation end products as indicators of sterol content in human carotid atherosclerotic plaques Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-03-27 Raphael S Pinto, Guilherme S Ferreira, Gina Camillo R Silvestre, Monique de Fátima M Santana, Valéria S Nunes, Lucas Ledesma, Paula R Pinto, Sayonara Ivana S de Assis, Ubiratan F Machado, Erasmo S da Silva, Marisa Passarelli
Advanced glycation end products (AGEs) are independently related to cardiovascular disease (CVD) and favor cholesterol and oxysterol accumulation in macrophage foam cells. Soluble RAGE (sRAGE) impairs cellular AGE signaling alleviating the deleterious effects of AGE in atherogenesis. The association between plasma AGEs and sRAGE with the content of cholesterol, markers of cholesterol synthesis and
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Diabetes mellitus and the causes of hospitalisation in people with heart failure Diab. Vasc. Dis. Res. (IF 2.4) Pub Date : 2022-03-02 Anam Malik, Ellis Garland, Michael Drozd, Victoria Palin, Marilena Giannoudi, Sam Straw, Nick Jex, Andrew MN Walker, John Gierula, Maria Paton, Klaus K Witte, Mark T Kearney, Eylem Levelt, Richard M Cubbon
Introduction Diabetes mellitus (DM) is associated with increased risk of hospitalisation in people with heart failure and reduced ejection fraction (HFrEF). However, little is known about the causes of these events. Methods Prospective cohort study of 711 people with stable HFrEF. Hospitalisations were categorised by cause as: decompensated heart failure; other cardiovascular; infection or other non-cardiovascular