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Relationship between Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and the Risk of COVID-19: A Meta-Analysis J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2023-11-28 Hu Luoyi, Pan Yan, Fan Qihong
Introduction. Research shows the correlation between angiotensin-converting enzyme (ACE) deletion and insertion (D/I) polymorphism and COVID-19 risk; yet, conclusive evidence is still lacking. Thus, a meta-analysis of relevant articles was performed to more accurately estimate the relationship of ACE I/D polymorphism with the risk of COVID-19. Material and Methods. Relevant literature from the PubMed
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Genetic Variants Associated with High Susceptibility of Premature Ischemic Stroke J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2023-11-16 Irma Isordia-Salas, David Santiago-Germán, Rosa María Jiménez-Alvarado, Alfredo Leaños-Miranda
Background. Several polymorphisms had been associated with an increased risk of ischemic stroke, but results are inconclusive. The aim of this study was to examine the association between AGTR1 A1166C and TSP-1 N700S polymorphisms and ischemic stroke in a young Mexican population. Methods. In a case-control study, 250 years of age with ischemic stroke and 250 controls matched by age and gender were
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Timing Matters: Effects of Early and Late Estrogen Replacement Therapy on Glucose Metabolism and Vascular Reactivity in Ovariectomized Aged Wistar Rats J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2023-11-15 Diana Ramírez-Hernández, Pedro López-Sánchez, Diego Lezama-Martínez, Neidy M. Kuyoc-Arroyo, Jessica E. Rodríguez-Rodríguez, Salvador Fonseca-Coronado, Ignacio Valencia-Hernández, Jazmin Flores-Monroy
Cardiovascular disease incidence increases after menopause due to the loss of estrogen cardioprotective effects. However, there are conflicting data regarding the timing of estrogen therapy (ERT) and its effect on vascular dysfunction associated with impaired glucose metabolism. The aim of this work was to evaluate the effect of early and late ERT on blood glucose/insulin balance and vascular reactivity
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Renin Trajectories and Outcome in Stable Heart Failure with Reduced Ejection Fraction (HFrEF) on Contemporary Therapy: A Monocentric Study from an Austrian Tertiary Hospital Outpatient Clinic J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2023-10-31 Emilie Han, Suriya Prausmüller, Annika Weidenhammer, Georg Spinka, Henrike Arfsten, Philipp E. Bartko, Georg Goliasch, Martin Hülsmann, Noemi Pavo
Introduction. The renin-angiotensin system (RAS) is the main target of neurohumoral therapy in heart failure with reduced ejection fraction (HFrEF) effectively reducing mortality. Reasonably, renin might serve as a biomarker for risk prediction and therapy response. Renin indeed bears some additional value to clinical risk models, albeit the effect is not pronounced. Whether assessing renin trajectories
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New Viral Diseases and New Possible Remedies by Means of the Pharmacology of the Renin-Angiotensin System J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2023-7-12 Giovanni Sansoè, Manuela Aragno
All strains of SARS-CoV-2, as well as previously described SARS-CoV and MERS-CoV, bind to ACE2, the cell membrane receptor of β-coronaviruses. Monocarboxypeptidase ACE2 activity stops upon viral entry into cells, leading to inadequate tissue production of angiotensin 1-7 (Ang1-7). Acute lung injury due to the human respiratory syncytial virus (hRSV) or avian influenza A H7N9 and H5N1 viruses is also
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Angiotensin-Converting Enzyme and Hypertension: A Systemic Analysis of Various ACE Inhibitors, Their Side Effects, and Bioactive Peptides as a Putative Therapy for Hypertension J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2023-6-21 Hafiz Ahmad, Huma Khan, Shabirul Haque, Shameem Ahmad, Namita Srivastava, Azhar Khan
Hypertension is a major risk factor for heart attack, produce atherosclerosis (hardening of the arteries), congestive heart failure, stroke, kidney infection, blindness, end-stage renal infection, and cardiovascular diseases. Many mechanisms are involved in causing hypertension, i.e., via calcium channels, alpha and beta receptors, and the renin-angiotensin system (RAS). RAS has an important role in
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Biochemical Evaluation by Confirmatory Tests after Unilateral Adrenalectomy for Primary Aldosteronism J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2023-5-24 Shingo Murasawa, Kazunori Kageyama, Mari Usutani, Yuko Asari, Noriko Kinoshita, Yuki Nakada, Yutaka Watanuki, Shinobu Takayasu, Makoto Daimon
Primary aldosteronism (PA) is the most common cause of endocrine hypertension. Unilateral PA can be cured using unilateral adrenalectomy (Adx). PA surgery outcome (PASO) criteria, which include clinical and biochemical outcomes, have been proposed to evaluate PA cure after Adx. However, clinical outcomes are often inconsistent with biochemical outcomes. In addition, although confirmatory tests are
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Association between Interactions among ACE Gene Polymorphisms and Essential Hypertension in Patients in the Hefei Region, Anhui, China J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2023-4-13 Li Wang, Ting-ting Song, Chang-wu Dong
Objective. Essential hypertension (EH) is a common cardiovascular disease that endangers human health. Its pathogenesis is complex and has not been fully elucidated. We explore the association between EH and interactions among polymorphisms of the angiotensin converting enzyme (ACE) gene in the Hefei region, Anhui, China. Methods. A total of 500 participants (400 hypertensive and 100 normotensive)
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Single Nucleotide Variants (SNVs) of Angiotensin-Converting Enzymes (ACE1 and ACE2): A Plausible Explanation for the Global Variation in COVID-19 Prevalence J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2023-4-3 Saad Mahjub Atiku, Dennis Kasozi, Katrina Campbell
Background. Although it is common knowledge that the coronavirus disease of 2019 (COVID-19) and other viral infections have an uneven impact globally, the reasons for this are still indistinct. The absence of equivalent capacities worldwide in screening, testing, and reporting of cases is one of the ideas put forward to explain this discrepancy. The molecular developments are noteworthy, particularly
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Hyperoside Ameliorates Renal Tubular Oxidative Damage and Calcium Oxalate Deposition in Rats through AMPK/Nrf2 Signaling Axis J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2023-3-11 Hongyang Tian, Qi Liang, Zhen Shi, Hang Zhao
Background. Nephrolithiasis is a common disease that seriously affects the health and life quality of patients. Despite the reported effect of hyperoside (Hyp) against nephrolithiasis, the specific mechanism has not been clarified. Therefore, this study is aimed at investigating the effect and potential mechanism of Hyp on renal injury and calcium oxalate (CaOx) crystal deposition. Methods. Rat and
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Review on the Biogenesis of Platelets in Lungs and Its Alterations in SARS-CoV-2 Infection Patients J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2023-2-27 Balasundaram Nandhini, Yacobu Sureshraj, Mohandass Kaviya, Thangavelu Sangeetha, Kathirvel Bharathi, Balasubramanian Balamuralikrishnan, Pappuswamy Manikantan, Meyyazhagan Arun, Kuchi Bhotla Haripriya, Pushparaj Karthika, Subramaniam Kalidass, Arumugam Vijaya Anand
Thrombocytes (platelets) are the type of blood cells that are involved in hemostasis, thrombosis, etc. For the conversion of megakaryocytes into thrombocytes, the thrombopoietin (TPO) protein is essential which is encoded by the TPO gene. TPO gene is present in the long arm of chromosome number 3 (3q26). This TPO protein interacts with the c-Mpl receptor, which is present on the outer surface of megakaryocytes
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Bioinformatics Analysis of the Inflammation-Associated lncRNA-mRNA Coexpression Network in Type 2 Diabetes J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2023-2-22 Linjuan Huang, Shengxi Xiong, Hanshuang Liu, Min Li, Ranran Zhang, Yan Liu, Xiaolei Hu
Introduction. Diabetes is a chronic inflammatory state, and a key role of lncRNAs in diabetes complications is a new area of research. Methods. In this study, key lncRNAs related to diabetes inflammation were identified by RNA-chip mining and lncRNA-mRNA coexpression network construction and finally verified by RT-qPCR. Results. We ultimately obtained 12 genes, including A1BG-AS1, AC084125.4, RAMP2-AS1
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Polymorphisms in the Renin-Angiotensin System and eNOS Glu298Asp Genes Are Associated with Increased Risk for Essential Hypertension in a Mexican Population J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2023-2-17 Irma Isordia-Salas, David Santiago-Germán, Alejandro Flores-Arizmendi, Alfredo Leaños-Miranda
Background. Essential hypertension is the result of modifiable and genetic factors, and it is associated with increased risk for atherothrombosis. Some polymorphisms are associated with hypertensive disease. The objective was to analyze the association between eNOS Glu298Asp, MTHR C677T, AGT M235T, AGT T174M, and A1166C and ACE I/D polymorphisms with essential hypertension in the Mexican population
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Analysis of Mechanisms for Increased Blood Pressure Variability in Rats Continuously Infused with Angiotensin II J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2023-1-4 Danfeng Jiang, Minami Matsuzaki, Yukiko Kawagoe, Kazuo Kitamura, Toshihiro Tsuruda, Koichi Kaikita, Yujiro Asada, Johji Kato
Objective. We reported that rats infused with angiotensin II (Ang II) are not only a model of hypertension but also of augmented 24 h blood pressure variability (BPV). In this study, we examined the mechanisms for Ang II-induced BPV, focusing on BP, heart rate (HR), baroreceptor reflex sensitivity (BRS), and medial area of the aortic arch. Methods. Nine-week-old male Wistar rats were infused with subcutaneous
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IgA Nephropathy with Macroproteinuria and a GFR of 20-30 ml/min/1.73 m2 May Still Benefit from RAS Inhibition J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-12-30 Ying Wang, Shimin Jiang, Guming Zou, Li Zhuo, Wenge Li
Introduction. There has been controversy about renin-angiotensin system (RAS) inhibition in IgAN patients with advanced (stage 4) chronic kidney disease (CKD). Therefore, we investigated the effect of RAS blockade in these patients. Methods. Renal specimens of 50 IgAN patients who underwent renal biopsy during stage 4 CKD between 2010 and 2020, were stained using immunohistochemistry to detect the
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Angiotensin-Converting Enzyme (ACE) Insertion/Deletion (I/D) Polymorphism as a Conjoint Regulator of Coagulation, Fibrinolytic, and RAAS Pathway in Infertility and Associated Pregnancy Complications J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-11-29 Sunil Thakur, Vaishnavi Sharma, Dipneet Kaur, Pulakes Purkait
Despite the increase in assisted reproductive technologies, the high rates of infertility and pregnancy complications are a major concern to infertility specialists worldwide. Infertility may be attributed to pregnancy complications like thrombophilia, preeclampsia and fibrin-induced recurrent pregnancy loss (RPL). Renin-angiotensin-aldosterone system (RAAS) directly or indirectly causes preeclampsia
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Type XXVIII Collagen Regulates Renal Interstitial Fibrosis and Epithelial-Mesenchymal Transition by SREBP1-Mediated HKDC1 Expression J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-11-26 Linlin Li, Qi Zou, Binbin Li, Lushi Huang, Lixin Wei
Background. A novel collagen called type XXVIII collagen (COL28) is involved in cancer and lung fibrosis. Preliminary data showed that renal tubular epithelial cells could proliferate, migrate, and undergo an epithelial-mesenchymal transition (EMT) when COL28 was overexpressed; however, it is still unknown how this occurs and what the underlying mechanism is. Methods. We analyzed the differential expression
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Fibrinogen-to-Albumin Ratio Predicts Postcontrast Acute Kidney Injury in Patients with Non-ST Elevation Acute Coronary Syndrome after Implantation of Drug-Eluting Stents J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-11-23 Yong Qiao, Mingkang Li, Linqing Li, Chengchun Tang
Background. Postcontrast acute kidney injury (PC-AKI) is an adverse reaction to iodinated contrast agents. In this study, we investigated the use of fibrinogen-to-albumin ratio (FAR) as a novel inflammatory marker to track the development and progression of PC-AKI in patients with non-ST elevation acute coronary syndrome (NSTE-ACS) after the implantation of drug-eluting stents (DESs). Methods. A total
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View of the Renin-Angiotensin System in Acute Kidney Injury Induced by Renal Ischemia-Reperfusion Injury J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-10-22 Farzaneh Karimi, Maryam Maleki, Mehdi Nematbakhsh
Renal ischemia-reperfusion injury (RIRI) is a sequence of complicated events that is defined as a reduction of the blood supply followed by reperfusion. RIRI is the leading cause of acute kidney injury (AKI). Among the diverse mediators that take part in RIRI-induced AKI, the renin-angiotensin system (RAS) plays an important role via conventional (angiotensinogen, renin, angiotensin-converting enzyme
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Influence of SERPINA1 Gene Polymorphisms on Anemia and Chronic Obstructive Pulmonary Disease J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-10-17 Thangavelu Sangeetha, Tajuddin Nargis Begum, Balasubramanian Balamuralikrishnan, Meyyazhagan Arun, Kannan R. R. Rengasamy, Natchiappan Senthilkumar, Shanmugam Velayuthaprabhu, Muthukrishnan Saradhadevi, Palanisamy Sampathkumar, Arumugam Vijaya Anand
Background. Anemia is one of the predominant hematological conditions, whereas chronic obstructive pulmonary disease (COPD) is a predominant respiratory disease. These two diseases were found to be interlinked, but the physiological pathways are still unclear. Aim. The current study has been aimed at analysing the genetic interrelationship between anemia and COPD in accordance with different altitudes
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Eplerenone Prevents Cardiac Fibrosis by Inhibiting Angiogenesis in Unilateral Urinary Obstruction Rats. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-09-17 Yi Chang,Ying Ben,Hui Li,Yunzhao Xiong,Gege Chen,Juan Hao,Xuelian Ma,Xiaomeng Gao,Panpan Qiang,Tatsuo Shimosawa,Xiangting Wang,Fan Yang,Qingyou Xu
Introduction Cardiovascular disease constitutes the leading cause of mortality in patients with chronic kidney disease (CKD), which is termed cardiorenal syndrome type 4 (CRS-4). Here, we report the development of pathological cardiac remodeling and fibrosis in unilateral urinary obstruction (UUO) rats. Methods Hematoxylin and eosin (H&E) staining was performed to observe the pathology of myocardial
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Exploring the Impact of ACE Inhibition in Immunity and Disease J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-08-04 Delia Oosthuizen, Edward D. Sturrock
Angiotensin-converting enzyme (ACE) is a zinc-dependent dipeptidyl carboxypeptidase and is crucial in the renin-angiotensin-aldosterone system (RAAS) but also implicated in immune regulation. Intrinsic ACE has been detected in several immune cell populations, including macrophages and neutrophils, where its overexpression results in enhanced bactericidal and antitumour responses, independent of angiotensin
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Estradiol Supplement or Induced Hypertension May Attenuate the Angiotensin II Type 1 Receptor Antagonist-Promoted Renal Blood Flow Response to Graded Angiotensin II Administration in Ovariectomized Rats J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-07-01 Samira Choopani, Mehdi Nematbakhsh
Backgrounds. Estrogen replacement therapy (ERT) and hypertension may influence females’ renin-angiotensin system (RAS) and its components. The angiotensin II (Ang II) type 1 receptor (AT1R) antagonist (losartan) may promote renal blood flow (RBF), and it is widely used in the clinic to control hypertension. The main objective of this study was the effects of estradiol or induced hypertension on RBF
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The Effect of the Angiotensin-Converting Enzyme Inhibitor on Bone Health in Castrated Hypertensive Rats Is Mediated via the Kinin-Kallikrein System J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-06-14 Na Zhang, Yanan Huo, Chen Yao, Jie Sun, Yafeng Zhang
Background. In previous studies, angiotensin-converting enzyme inhibitor (ACEI) use was associated with increased bone loss, while an angiotensin II type I receptor blocker had no effect on bone loss in elder subjects, which suggested that the effect of ACEI on bone loss was not mediated through the classical renin-angiotensin system. In this study, we set to investigate whether the effect of ACEI
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The Race for ACE: Targeting Angiotensin-Converting Enzymes (ACE) in SARS-CoV-2 Infection J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-05-27 Elisabeth Schieffer, Bernhard Schieffer
The SARS-CoV-2 virus is spreading around the world, and its clinical manifestation COVID-19 is challenging medical, economic, and social systems. With more and more scientific and social media reports on the COVID-19 pandemic appearing, differences in geographical presentations and clinical management occur. Since ACE2 (angiotensin-converting enzyme 2) is the gatekeeper receptor for the SARS-CoV-2
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The Association of Serum AIM2 Level with the Prediction and Short-Term Prognosis of Coronary Artery Disease J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-05-14 Wenkang Zhang, Gaoliang Yan, Chunyang Xu, Chengchun Tang
Objective. Coronary artery disease (CAD), one of the commonest cardiovascular diseases, has high morbidity and mortality. Absent in melanoma 2 (AIM2) is involved in atherosclerosis, and no clinical trials have explored the association between AIM2 and CAD. Therefore, this study was aimed at evaluating the predictive and short-term prognostic value of AIM2 for CAD. Methods. 279 patients who underwent
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Cardiorenal Disease in COVID-19 Patients J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-03-18 Muhtasham Sifaat, Pinak Patel, Razan Sheikh, Dawood Ghaffar, Hitesh Vaishnav, Ludmila Nahar, Sonia Rupani, Syed Quadri
Coronavirus disease 2019 (COVID-19) is an illness caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Mutations in the genetic coding and the variations in the spike proteins are critical for the virus’s mechanism of facilitating fusion with the human host, making the disease more severe. Recent research indicates that comorbidities including diabetes
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Associations between AGT M235T Polymorphism and Cancer: An Updated Meta-Analysis J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-03-04 Junyan Kou, Jing Huang
We assessed the relationship between AGT gene M235T polymorphism and the susceptibility to cancer by performing an updated meta-analysis. This study retrospectively searched related articles in the electronic databases. Afterwards, we determined combined odds ratios (ORs) and related 95% confidence intervals (CIs) by the fixed- or random-effects model. The present meta-analysis enrolled altogether
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Ocular Distribution of the Renin-Angiotensin-Aldosterone System in the Context of the SARS-CoV-2 Pandemic J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-02-03 Ali Abid, Muhammad Azaan Khan, Brendon Lee, Andrew White, Nicole Carnt, Sana Arshad, Chameen Samarawickrama
The COVID-19 pandemic has resulted in an unprecedented impact on global health, economy, and way of life. SARS-CoV-2, the virus responsible for the disease, utilizes the ACE2 receptor found on host cells to mediate entry, replication, and infection. Numerous studies have elucidated the presence of many components of the renin-angiotensin-aldosterone system (RAAS) in the eye, including the ACE2 receptor
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Tolvaptan Improves Contrast-Induced Acute Kidney Injury J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-01-30 Chunyang Xu, Xu Huang, Gaoliang Yan, Dong Wang, Meijuan Hu, Chengchun Tang
Objective. Contrast-induced acute kidney injury (CI-AKI) is a serious side effect of contrast media use. The purpose of this study was to investigate the role and mechanism of tolvaptan (TOL) in CI-AKI. Methods. 24 Wistar male rats were randomly divided into 4 groups (). And a rat model of CI-AKI was established. Then, the blood and urine of rats in each group were collected to detect relevant parameters
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Role and Mechanism of the Renin-Angiotensin-Aldosterone System in the Onset and Development of Cardiorenal Syndrome J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-01-24 Kexin Ma, Weifang Gao, Huazhou Xu, Wenjie Liang, Guoping Ma
Cardiorenal syndrome (CRS), a clinical syndrome involving multiple pathological mechanisms, exhibits high morbidity and mortality. According to the primary activity of the disease, CRS can be divided into cardiorenal syndrome (type I and type II), renal heart syndrome (type III and type IV), and secondary heart and kidney disease (type V). The renin-angiotensin-aldosterone system (RAAS) is an important
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Empagliflozin Alleviates Left Ventricle Hypertrophy in High-Fat-Fed Mice by Modulating Renin Angiotensin Pathway J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-01-18 Juliana Cordovil Cotrin, Gabriel Santos Martins de Souza, Tamiris Ingrid Petito-da-Silva, Luiz Eduardo Macedo Cardoso, Vanessa Souza-Mello, Sandra Barbosa-da-Silva
Aims. The cardiobenefits of empagliflozin are multidimensional, and some mechanisms are still unclear. The aim of the present study was to evaluate the effect of treatment with empagliflozin on biometric parameters and gene expression in the local cardiac RAS, oxidative stress, and endoplasmic reticulum pathways in a mouse model. Main Methods. Forty male C57BL/6 mice were fed with control (C) or high-fat
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Long-Term Mortality and Morbidity Related to Congestive Heart Failure with Reduced Ejection Fraction (CHFrEF) in Palestinian Patients Maintained on Submaximal Sacubitril/Valsartan Doses: A Pilot Study J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-12-28 Raed Aqel, Tareq Z. Alzughayyar, Sadi A. Abukhalaf, Rami A. Misk, Jihad Samer Zalloum
Background. The efficacy of sacubitril/valsartan, a newly introduced combination drug for heart failure with reduced ejection fraction (HFrEF), was demonstrated in the PARADIGM-HF trial conducted in Western countries. However, these findings need to be verified in the Middle Eastern context, where patients may exhibit a different response due to different environmental and racial factors. Objectives
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Transmission Jeopardy of Adenomatosis Polyposis Coli and Methylenetetrahydrofolate Reductase in Colorectal Cancer J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-12-10 Younis Mohd, Parvinder Kumar, Haripriya Kuchi Bhotla, Arun Meyyazhagan, Balamuralikrishnan Balasubramanian, Mithun Kumar Ramesh Kumar, Manikantan Pappusamy, Karthick Kumar Alagamuthu, Antonio Orlacchio, Sasikala Keshavarao, Palanisamy Sampathkumar, Vijaya Anand Arumugam
Colorectal cancer (CRC) is one of the globally prevalent and virulent types of cancer with a distinct alteration in chromosomes. Often, any alterations in the adenomatosis polyposis coli (APC), a tumor suppressor gene, and methylenetetrahydrofolate reductase (MTHFR) gene are related to surmise colorectal cancer significantly. In this study, we have investigated chromosomal and gene variants to discern
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Role and Mechanism of the Renin-Angiotensin-Aldosterone System in the Onset and Development of Cardiorenal Syndrome. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-01-24 Kexin Ma,Weifang Gao,Huazhou Xu,Wenjie Liang,Guoping Ma
Cardiorenal syndrome (CRS), a clinical syndrome involving multiple pathological mechanisms, exhibits high morbidity and mortality. According to the primary activity of the disease, CRS can be divided into cardiorenal syndrome (type I and type II), renal heart syndrome (type III and type IV), and secondary heart and kidney disease (type V). The renin-angiotensin-aldosterone system (RAAS) is an important
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Empagliflozin Alleviates Left Ventricle Hypertrophy in High-Fat-Fed Mice by Modulating Renin Angiotensin Pathway. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2022-01-18 Juliana Cordovil Cotrin,Gabriel Santos Martins de Souza,Tamiris Ingrid Petito-da-Silva,Luiz Eduardo Macedo Cardoso,Vanessa Souza-Mello,Sandra Barbosa-da-Silva
Aims. The cardiobenefits of empagliflozin are multidimensional, and some mechanisms are still unclear. The aim of the present study was to evaluate the effect of treatment with empagliflozin on biometric parameters and gene expression in the local cardiac RAS, oxidative stress, and endoplasmic reticulum pathways in a mouse model. Main Methods. Forty male C57BL/6 mice were fed with control (C) or high-fat
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Long-Term Mortality and Morbidity Related to Congestive Heart Failure with Reduced Ejection Fraction (CHFrEF) in Palestinian Patients Maintained on Submaximal Sacubitril/Valsartan Doses: A Pilot Study. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-12-28 Raed Aqel,Tareq Z Alzughayyar,Sadi A Abukhalaf,Rami A Misk,Jihad Samer Zalloum
BACKGROUND The efficacy of sacubitril/valsartan, a newly introduced combination drug for heart failure with reduced ejection fraction (HFrEF), was demonstrated in the PARADIGM-HF trial conducted in Western countries. However, these findings need to be verified in the Middle Eastern context, where patients may exhibit a different response due to different environmental and racial factors. OBJECTIVES
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Transmission Jeopardy of Adenomatosis Polyposis Coli and Methylenetetrahydrofolate Reductase in Colorectal Cancer. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-12-10 Younis Mohd,Parvinder Kumar,Haripriya Kuchi Bhotla,Arun Meyyazhagan,Balamuralikrishnan Balasubramanian,Mithun Kumar Ramesh Kumar,Manikantan Pappusamy,Karthick Kumar Alagamuthu,Antonio Orlacchio,Sasikala Keshavarao,Palanisamy Sampathkumar,Vijaya Anand Arumugam
Colorectal cancer (CRC) is one of the globally prevalent and virulent types of cancer with a distinct alteration in chromosomes. Often, any alterations in the adenomatosis polyposis coli (APC), a tumor suppressor gene, and methylenetetrahydrofolate reductase (MTHFR) gene are related to surmise colorectal cancer significantly. In this study, we have investigated chromosomal and gene variants to discern
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Recent Advances in the Endogenous Brain Renin-Angiotensin System and Drugs Acting on It J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-11-30 Aswar Urmila, Patil Rashmi, Ghag Nilam, Bodhankar Subhash
The RAS (renin-angiotensin system) is the part of the endocrine system that plays a prime role in the control of essential hypertension. Since the discovery of brain RAS in the seventies, continuous efforts have been put by the scientific committee to explore it more. The brain has shown the presence of various components of brain RAS such as angiotensinogen (AGT), converting enzymes, angiotensin (Ang)
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Recent Advances in the Endogenous Brain Renin-Angiotensin System and Drugs Acting on It. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-11-30 Aswar Urmila,Patil Rashmi,Ghag Nilam,Bodhankar Subhash
The RAS (renin-angiotensin system) is the part of the endocrine system that plays a prime role in the control of essential hypertension. Since the discovery of brain RAS in the seventies, continuous efforts have been put by the scientific committee to explore it more. The brain has shown the presence of various components of brain RAS such as angiotensinogen (AGT), converting enzymes, angiotensin (Ang)
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Alamandine: Potential Protective Effects in SARS-CoV-2 Patients J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-11-08 Ava Soltani Hekmat, Kazem Javanmardi
Coronavirus disease 2019 (COVID-19) can occur due to contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has no confined treatment and, consequently, has high hospitalization and mortality rates. Moreover, people who contract COVID-19 present systemic inflammatory spillover. It is now known that COVID-19 pathogenesis is linked to the renin-angiotensin system (RAS). COVID-19
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Alamandine: Potential Protective Effects in SARS-CoV-2 Patients. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-11-08 Ava Soltani Hekmat,Kazem Javanmardi
Coronavirus disease 2019 (COVID-19) can occur due to contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has no confined treatment and, consequently, has high hospitalization and mortality rates. Moreover, people who contract COVID-19 present systemic inflammatory spillover. It is now known that COVID-19 pathogenesis is linked to the renin-angiotensin system (RAS). COVID-19
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The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-09-21 Guoqing Yao, Wenjing Li, Wenzhao Liu, Jingbo Xing, Cheng Zhang
Objective. Angiotensin-III (Ang-III) is the downstream product of angiotensin-II (Ang-II) metabolized by aminopeptidase A (APA). At present, the research of Ang-III mainly concentrates on hypertension and the central renin-angiotensin system (RAS). However, few studies have focused on the relationship between Ang-III and coronary atherosclerosis (CAS). Methods and Results. Plasma Ang-III and APA levels
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The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-09-21 Guoqing Yao,Wenjing Li,Wenzhao Liu,Jingbo Xing,Cheng Zhang
OBJECTIVE Angiotensin-III (Ang-III) is the downstream product of angiotensin-II (Ang-II) metabolized by aminopeptidase A (APA). At present, the research of Ang-III mainly concentrates on hypertension and the central renin-angiotensin system (RAS). However, few studies have focused on the relationship between Ang-III and coronary atherosclerosis (CAS). METHODS AND RESULTS Plasma Ang-III and APA levels
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Human Ace D/I Polymorphism Could Affect the Clinicobiological Course of COVID-19 J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-09-17 Elifcan Aladag, Zahit Tas, Bilgesu Safak Ozdemir, Tayfun Hilmi Akbaba, Meltem Gulsun Akpınar, Hakan Goker, Tugce Unalan-Altintop, Ahmet Cagkan Inkaya, Alpaslan Alp, Gokhan Metan, Ibrahim Celalettin Haznedaroglu, Banu Balci-Peynircioglu, Nilgun Sayinalp
Introduction. The coronavirus disease 2019 (COVID-19), that is caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), has spread rapidly worldwide since December 2019. The SARS-CoV-2 virus has a great affinity for the angiotensin-converting enzyme-2 (ACE-2) receptor, which is an essential element of the renin-angiotensin system (RAS). This study is aimed at assessing the impact of
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Human Ace D/I Polymorphism Could Affect the Clinicobiological Course of COVID-19. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-09-15 Elifcan Aladag,Zahit Tas,Bilgesu Safak Ozdemir,Tayfun Hilmi Akbaba,Meltem Gulsun Akpınar,Hakan Goker,Tugce Unalan-Altintop,Ahmet Cagkan Inkaya,Alpaslan Alp,Gokhan Metan,Ibrahim Celalettin Haznedaroglu,Banu Balci-Peynircioglu,Nilgun Sayinalp
INTRODUCTION The coronavirus disease 2019 (COVID-19), that is caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), has spread rapidly worldwide since December 2019. The SARS-CoV-2 virus has a great affinity for the angiotensin-converting enzyme-2 (ACE-2) receptor, which is an essential element of the renin-angiotensin system (RAS). This study is aimed at assessing the impact of
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Losartan and Eprosartan Induce a Similar Effect on the Acute Rise in Serum Uric Acid Concentration after an Oral Fructose Load in Patients with Metabolic Syndrome J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-08-26 Anna Masajtis-Zagajewska, Jacek Majer, Michał Nowicki
Introduction. Excessive intake of fructose increases serum uric acid concentration. Hyperuricemia induces a negative effect on atherosclerosis and inflammation. Hyperuricemia is common in patients with arterial hypertension. Several antihypertensive drugs including diuretics increase serum uric acid concentration. In contrast, the angiotensin II receptor antagonist (ARB) losartan was found to lower
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Losartan and Eprosartan Induce a Similar Effect on the Acute Rise in Serum Uric Acid Concentration after an Oral Fructose Load in Patients with Metabolic Syndrome. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-08-25 Anna Masajtis-Zagajewska,Jacek Majer,Michał Nowicki
INTRODUCTION Excessive intake of fructose increases serum uric acid concentration. Hyperuricemia induces a negative effect on atherosclerosis and inflammation. Hyperuricemia is common in patients with arterial hypertension. Several antihypertensive drugs including diuretics increase serum uric acid concentration. In contrast, the angiotensin II receptor antagonist (ARB) losartan was found to lower
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Angiotensin Receptor Blocker and Neprilysin Inhibitor Suppresses Cardiac Dysfunction by Accelerating Myocardial Angiogenesis in Apolipoprotein E-Knockout Mice Fed a High-Fat Diet J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-08-04 Yasunori Suematsu, Kohei Tashiro, Hidetaka Morita, Akihito Ideishi, Takashi Kuwano, Shin-ichiro Miura
Hypothesis. Myocardial angiogenesis is important for maintaining cardiac contractile function in patients with cardiac hypertrophy. Evidence shows that angiotensin receptor blocker and neprilysin inhibitors (ARNIs) improve heart failure. The present study investigated the myocardial angiogenic effect of valsartan plus sacubitril in early-stage cardiac dysfunction. Materials and Methods. Male apolipoprotein
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Angiotensin Receptor Blocker and Neprilysin Inhibitor Suppresses Cardiac Dysfunction by Accelerating Myocardial Angiogenesis in Apolipoprotein E-Knockout Mice Fed a High-Fat Diet. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-08-04 Yasunori Suematsu,Kohei Tashiro,Hidetaka Morita,Akihito Ideishi,Takashi Kuwano,Shin-Ichiro Miura
MATERIALS AND METHODS Male apolipoprotein E-knockout mice fed a high-fat diet were divided into control (CTL), valsartan (30 mg/kg) (VAL), sacubitril (30 mg/kg) (SAC), and valsartan plus sacubitril (30 mg/kg each) (VAL/SAC) groups after 4 weeks of prefeeding and were subsequently treated for 12 weeks. RESULTS The VAL/SAC group exhibited significantly higher serum brain natriuretic peptide levels; more
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Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-08-03 Chenghu Huang, Pan Lei, Caibi Peng, Min Li, Yifei Guo, Xuefeng Li
Hypothesis/Introduction. Berberine, a natural compound, has multiple pharmacological activities to promote islet function. We hypothesized that berberine could reshape the local renin-angiotensin system (RAS) balance to ameliorate the development of obesity via the modulation of autophagy. Materials and methods. After 8 weeks of administration of intragastric berberine to ob/ob mice, metabolic parameters
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Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-08-03 Chenghu Huang,Pan Lei,Caibi Peng,Min Li,Yifei Guo,Xuefeng Li
RESULTS Prolonged exposure to palmitate increased the expression of ACE and AngII type 1 receptor (ATR1) and decreased the ACE2 expression, which was partly offset by berberine. In ob/ob mice, berberine increased in tolerance to glucose, improved abnormal β-cell and α-cell distributions, upregulated ACE2 expression, and decreased autophagosomes and the expression of LC3 and SQSTM1/p62. Autophagosomes
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Aldosterone Induces the Proliferation of Renal Tubular Epithelial Cells In Vivo but Not In Vitro J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-07-28 Juan Hao, Lingjin Liu, Ziqian Liu, Gege Chen, Yunzhao Xiong, Xiangting Wang, Xuelian Ma, Qingyou Xu
Objective. To investigate the proliferation effect of aldosterone on renal tubular epithelial cells in vivo and in vitro. Methods. Thirty-two male C57BL/6J mice (20–22 g) were divided randomly into four groups: sham, unilateral nephrectomy (UN), unilateral nephrectomy plus aldosterone infusion (UA), and UA plus eplerenone (UAE). The kidneys were removed 6 weeks after treatment. Expression of proliferating
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Aldosterone Induces the Proliferation of Renal Tubular Epithelial Cells In Vivo but Not In Vitro. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-07-26 Juan Hao,Lingjin Liu,Ziqian Liu,Gege Chen,Yunzhao Xiong,Xiangting Wang,Xuelian Ma,Qingyou Xu
OBJECTIVE To investigate the proliferation effect of aldosterone on renal tubular epithelial cells in vivo and in vitro. METHODS Thirty-two male C57BL/6J mice (20-22 g) were divided randomly into four groups: sham, unilateral nephrectomy (UN), unilateral nephrectomy plus aldosterone infusion (UA), and UA plus eplerenone (UAE). The kidneys were removed 6 weeks after treatment. Expression of proliferating
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Alterations in Gene Expression of Renin-Angiotensin System Components and Related Proteins in Colorectal Cancer J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-07-06 Danial Mehranfard, Gabriela Perez, Andres Rodriguez, Julia M. Ladna, Christopher T. Neagra, Benjamin Goldstein, Timothy Carroll, Alice Tran, Malav Trivedi, Robert C. Speth
Hypothesis/Introduction. Recent studies suggest involvement of the renin-angiotensin system (RAS) in cancers, including colorectal cancer (CRC). This study focuses on the association of genes encoding 17 proteins related to the RAS within a Japanese male CRC population. Materials and Methods. Quantitative expression of the RNA of these 17 genes in normal and cancerous tissues obtained using chip arrays
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Alterations in Gene Expression of Renin-Angiotensin System Components and Related Proteins in Colorectal Cancer. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-07-05 Danial Mehranfard,Gabriela Perez,Andres Rodriguez,Julia M Ladna,Christopher T Neagra,Benjamin Goldstein,Timothy Carroll,Alice Tran,Malav Trivedi,Robert C Speth
MATERIALS AND METHODS Quantitative expression of the RNA of these 17 genes in normal and cancerous tissues obtained using chip arrays from the public functional genomics data repository, Gene Expression Omnibus (GEO) application, was compared statistically. RESULTS Expression of four genes, AGT (angiotensinogen), ENPEP (aminopeptidase A) MME (neprilysin), and PREP (prolyl endopeptidase), was significantly
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Effects of the Na+/H+ Ion Exchanger on Susceptibility to COVID-19 and the Course of the Disease. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-06-15 Medine Cumhur Cure,Erkan Cure
The Na+/H+ ion exchanger (NHE) pumps Na+ inward the cell and H+ ion outside the cell. NHE activity increases in response to a decrease in intracellular pH, and it maintains intracellular pH in a narrow range. Patients with obesity, diabetes, and hypertension and the elderly are prone to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The angiotensin II (Ang II) level is high
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Angiotensin II Induces Differentiation of Human Neuroblastoma Cells by Increasing MAP2 and ROS Levels. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-06-14 Bryan Jael Collazo,Dariana Morales-Vázquez,Jaylene Álvarez-Del Valle,Javier E Sierra-Pagan,Juan Carlos Medina,Jarold Méndez-Álvarez,Yamil Gerena
INTRODUCTION The roles of angiotensin II (Ang II) in the brain are still under investigation. In this study, we investigated if Ang II influences differentiation of human neuroblastoma cells with simultaneous activation of NADPH oxidase and reactive oxygen species (ROS). Moreover, we investigated the Ang II receptor type involved during differentiation. METHODS Human neuroblastoma cells (SH-SY5Y; 5
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Exploring the Mystery of Angiotensin-Converting Enzyme II (ACE2) in the Battle against SARS-CoV-2. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-06-04 Divakar Sharma,Juhi Sharma,Amit Singh
COVID-19 is the newly born pandemic caused by the SARS-CoV-2 virus, which is the recently emerged betacoronavirus that crosses the species barrier. It predominantly infects pneumocytes of the respiratory tract, but due to the presence of angiotensin-converting enzyme II (ACE2) on other cells like surface enterocytes of the upper esophagus and colon, these are also considered as the primary sites of
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Assessment of Alamandine in Pulmonary Fibrosis and Respiratory Mechanics in Rodents. J. Renin Angiotensin Aldosterone Syst. (IF 2.9) Pub Date : 2021-05-18 Renata Streck Fernandes,Henrique Bregolin Dias,Wynnie Amaral de Souza Jaques,Tiago Becker,Katya Rigatto
INTRODUCTION Pulmonary fibrosis (PF) is characterized by an accelerated decline in pulmonary function and has limited treatment options. Alamandine (ALA) is a recently described protective peptide of the renin-angiotensin system (RAS) with essential tasks in several conditions. Our group previously demonstrated that ALA is reduced by 365% in the plasma of patients with idiopathic PF, and thus, it is