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Contribution of platelets to disruption of the blood-brain barrier during arterial baroreflex dysfunction Microvasc. Res. (IF 3.1) Pub Date : 2024-03-16 Bowen Shen, Lili Yang, Xiaoli Jia, Deping Kong, Yongfeng Gao, Shan Gao, Ruimin Chen, Fengbao Chen, Chunyu Zhao, Yue Li, Rui Tan, Xiaomin Zhao
Arterial baroreflex dysfunction, like many other central nervous system disorders, involves disruption of the blood-brain barrier, but what causes such disruption in ABR dysfunction is unclear. Here we explored the potential role of platelets in this disruption. ABR dysfunction was induced in rats using sinoaortic denervation, and the effects on integrity of the blood-brain barrier were explored based
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Improved nested U-structure for accurate nailfold capillary segmentation Microvasc. Res. (IF 3.1) Pub Date : 2024-03-13 Qianyao Ye, Hao Yin, Jianan Lin, Junzhao Liang, Mugui Xie, Cong Ye, Bin Zhou, An Huang, Zhiwei Wu, Xiaosong Li, Yanxiong Wu
Changes in the structure and function of nailfold capillaries may be indicators of numerous diseases. Noninvasive diagnostic tools are commonly used for the extraction of morphological information from segmented nailfold capillaries to study physiological and pathological changes therein. However, current segmentation methods for nailfold capillaries cannot accurately separate capillaries from the
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Psoriatic arthritis – A vascular hypothesis Microvasc. Res. (IF 3.1) Pub Date : 2024-03-11 Sevdalina Nikolova Lambova
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Edible oil based optical clearing for optical coherence tomography angiography imaging Microvasc. Res. (IF 3.1) Pub Date : 2024-03-07 Abhishek Banerjee, Abhishek Indoliya, Raju Poddar
In optical imaging, optical clearing agents are commonly used to enhance the structural details of a sample. The current study investigates how to use it to improve the data obtained by an optical coherence tomography angiography system. A natural edible oil with no chemical base has been used for optical clearing. testing on mice and humans yielded excellent optical clearing. Using computational techniques
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Corrigendum to “Effect of crocetin on vascular smooth muscle cells migration induced by advanced glycosylation end products” [Microvasc. Res. 112 (2017) 30–36/ MVR_2016_83] Microvasc. Res. (IF 3.1) Pub Date : 2024-02-22 Min Xiang, Runlin Yang, Yaqin Zhang, Pingping Wu, Lizhen Wang, Zhenyu Gao, Jianmei Wang
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Coronary artery bypass grafting (CABG) induces pro-inflammatory and immunomodulatory phenotype of platelets in the absence of a pro-aggregatory state Microvasc. Res. (IF 3.1) Pub Date : 2024-02-13 Ehteramolsadat Hosseini, Javad Ahmadi, Faranak Kargar, Mehran Ghasemzadeh
Coronary artery bypass grafting (CABG) is considered the choice treatment for patients suffering from coronary artery disease (CAD). In the inflammatory milieu of cardiopulmonary bypass (CPB), systemic inflammatory response syndrome (SIRS) can induce a platelet pro-inflammatory state which could exacerbate post-CABG inflammatory status while affecting hemostatic function in patients. Therefore, focusing
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Decreased retinal capillary density as a beneficial response to 24-week high-speed circuit resistant training in healthy older adults Microvasc. Res. (IF 3.1) Pub Date : 2024-02-05 Ava-Gaye Simms, Rosalia Parrino, Gustavo Rosa Gameiro, Jack Cipolla, Jianhua Wang, Hong Jiang, Joseph F. Signorile
To determine the changes in retinal microvascular density after a 24-week high-speed circuit resistance training program (HSCT) in healthy older adults. Thirty healthy older adults were recruited and randomly assigned to either a training group (HSCT) or a non-training (CON) group. Fifteen subjects (age 73.3 ± 7.76 yrs) in the HSCT group exercised three times per week on non-consecutive days for 24 weeks
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Silymarin prevents endothelial dysfunction by upregulating Erk-5 in oxidized LDL exposed endothelial cells Microvasc. Res. (IF 3.1) Pub Date : 2024-02-01 Rohit Patel, Sanjay Kumar, Johnna F. Varghese, Navneendra Singh, Rana P. Singh, Umesh C.S. Yadav
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Reproducibility of Laser Doppler Flowmetry in gingival microcirculation. A study on six different protocols Microvasc. Res. (IF 3.1) Pub Date : 2024-01-30 Aida Ajan, Karin Roberg, Ingemar Fredriksson, Jahan Abtahi
Laser Doppler Flowmetry (LDF) is a non-invasive technique for the assessment of tissue blood flow, but increased reproducibility would facilitate longitudinal studies. The aim of the study was to assess the interday reproducibility of Laser Doppler Flowmetry (LDF) at rest, at elevated local temperatures, and with the use of the vasodilator Methyl Nicotinate (MN) in six interconnected protocols for
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Microvascular changes following exposure to iodinated contrast media in vitro. A qualitative comparison to serum creatinine concentrations in post-cardiac catheterization patients Microvasc. Res. (IF 3.1) Pub Date : 2024-01-28 Marine M.M. Magnusson, Ulrich Gerk, Gertraud Schüpbach, Juliane Rieger, Johanna Plendl, Ilka Marin, Barbara Drews, Sabine Kaessmeyer
Contrast-associated acute kidney injury (CA-AKI) is characterized as a loss of renal function following radiological contrast media administration. While all contrast media induce variable changes in microvascular endothelial cells , only few studies report clinical significance of their findings. A comprehensive assessment of the effect of iodinated contrast media on the renal function and is essential
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Angiographic microvascular resistance in patients with obstructive hypertrophic cardiomyopathy Microvasc. Res. (IF 3.1) Pub Date : 2024-01-24 Jie Ma, Ran Xia, Yue Lan, Anqi Wang, Yaxing Zhang, Lihong Ma
Coronary microvascular dysfunction (CMD) is an important feature of obstructive hypertrophic cardiomyopathy (oHCM). Angiographic microvascular resistance (AMR) offers a potent means for assessing CMD. This study sought to evaluate the prognostic value of CMD burden calculated by AMR among oHCM patients. We retrospectively screened all patients diagnosed with oHCM from Fuwai Hospital between January
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Corrigendum to “Numerical simulation of heat transfer in blood flow altered by electroosmosis through tapered micro-vessels” [Microvasc. Res. 118 (2018) 162-172] Microvasc. Res. (IF 3.1) Pub Date : 2024-01-23 J. Prakash, K. Ramesh, D. Tripathi, R. Kumar
Abstract not available
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Vascular endothelial glycocalyx shedding in ventilator-induced lung injury in rats Microvasc. Res. (IF 3.1) Pub Date : 2024-01-22 Dingqin Ou, Wenxia Xu, Zhaosen Feng, Yihan Yang, Wenqiang Xue, Qinyu Zhang, Xuan Li, Yuyang Zhu, Jie Huang, Yu Fang
Endothelial permeability deterioration is involved in ventilator-induced lung injury (VILI). The integrality of vascular endothelial glycocalyx (EG) is closely associated with endothelial permeability. The hypothesis was that vascular EG shedding participates in VILI through promoting endothelial permeability. In the present study, male Sprague-Dawley (SD) rats were ventilated with high tidal volume
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Sedation with propofol and isoflurane differs in terms of microcirculatory parameters: A randomized animal study using dorsal skinfold chamber mouse model Microvasc. Res. (IF 3.1) Pub Date : 2024-01-15 Christine Kang, Ah-Reum Cho, Haekyu Kim, Jae-Young Kwon, Hyeon Jeong Lee, Eunsoo Kim
This study aimed to explore the effects of sedative doses of propofol and isoflurane on microcirculation in septic mice compared to controls. Isoflurane, known for its potential as a sedation drug in bedside applications, lacks clarity regarding its impact on the microcirculation system. The hypothesis was that propofol would exert a more pronounced influence on the microvascular flow index, particularly
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Electronic vape fluid activates the pulmonary endothelium and disrupts vascular integrity in vitro through an ARF6-dependent pathway Microvasc. Res. (IF 3.1) Pub Date : 2024-01-14 Evangelene Blackham-Hayward, Zsuzsanna Kertesz, Havovi Chichger
The use of e-cigarettes or vapes is increasingly popular amongst a range of different demographics however the research in this area is surprisingly sparse. Clinical reports of e-cigarette- or vaping use-associated lung injury (EVALI) and vascular disruption, in both nicotine-containing and nicotine-free e-cigarette smokers, prompts the need for further research with a focus on the pulmonary endothelium
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Vascular read-out for TRP channel functionality on distal peripheral nerve endings in healthy men Microvasc. Res. (IF 3.1) Pub Date : 2024-01-10 Heleen Marynissen, Charlien Janssen, Dorien Bamps, Jan de Hoon
Background Quantification of the vasodilation after topical application of capsaicin or cinnamaldehyde is often implemented to indirectly assess Transient Receptor Potential (TRP) Vanilloid 1 (TRPV1) or Ankyrin 1 (TRPA1) functionality respectively. This method has been well-established on the human forearm. However, to enable TRP functionality assessments in distal peripheral neuropathy, the vascular
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Coronary microvascular dysfunction Microvasc. Res. (IF 3.1) Pub Date : 2024-01-09 Chunlin Zhu, Lina Miao, Kangkang Wei, Dazhuo Shi, Jie Gao
Coronary microvascular dysfunction (CMD) is a key mechanism underlying ischemic heart disease (IHD), yet its diagnosis and treatment remain challenging. This article presents a comprehensive overview of CMD research, covering its pathogenesis, diagnostic criteria, assessment techniques, risk factors, and therapeutic strategies. Additionally, it highlights the prospects for future CMD research. The
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Involvement of NEK2 and NEK9 in LPS - induced endothelial barrier dysfunction Microvasc. Res. (IF 3.1) Pub Date : 2024-01-02 Nektarios Barabutis, Mohammad S. Akhter
Endothelial hyperpermeability is the hallmark of severe lung injury, including acute respiratory distress syndrome. Despite the fact that Never In Mitosis A (NIMA)-related kinase 2 (NEK2) and NEK9 mediate fundamental cellular processes, our knowledge on their role in barrier function is limited. Herein we show that NEK2 and NEK9 inhibition suppresses LPS-induced paracellular hyperpermeability and myosin
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Absolute retinal blood flow in healthy eyes and in eyes with retinal vein occlusion Microvasc. Res. (IF 3.1) Pub Date : 2023-12-18 Thibaud Mautuit, Pierre Cunnac, Frédéric Truffer, André Anjos, Rebecca Dufrane, Gilbert Maître, Martial Geiser, Christophe Chiquet
Purpose To measure non-invasively retinal venous blood flow (RBF) in healthy subjects and patients with retinal venous occlusion (RVO). Methods The prototype named AO-LDV (Adaptive Optics Laser Doppler Velocimeter), which combines a new absolute laser Doppler velocimeter with an adaptive optics fundus camera (rtx1, Imagine Eyes®, Orsay, France), was studied for the measurement of absolute RBF as a
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Reduction of the trans-cortical vessel was associated with bone loss, another underlying mechanism of osteoporosis Microvasc. Res. (IF 3.1) Pub Date : 2023-12-18 Chun-Lin Xiao, Lu-Lin Liu, Wen Tang, Wu-Yang Liu, Long-Yan Wu, Kai Zhao
Rationale Numerous studies have established a robust association between bone morrow microvascular diseases and osteoporosis. This study sought to investigate the relationship between alterations in trans-cortical vessel (TCVs) and the onset of osteoporosis in various mouse models. Methods Aged mice, ovariectomized mice, and db/db mice, were utilized as osteoporosis models. TCVs in the tibia were detected
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Study of the f-cell ratio using plasma dilution and albumin mass kinetics Microvasc. Res. (IF 3.1) Pub Date : 2023-12-18 Robert G. Hahn
Background The f-cell ratio of 0.91 is a conversion factor between the hematocrit measured in peripheral blood and the hematocrit obtained by separate measurements of the red blood cell mass and plasma volume. The physiological background of the f-cell ratio is unclear. Methods Data were retrieved from 155 intravenous infusion experiments where 15–25 mL/kg of crystalloid fluid diluted the blood hemoglobin
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Post-occlusive reactive hyperemia variables can be used to diagnose vascular dysfunction in hemorrhagic shock Microvasc. Res. (IF 3.1) Pub Date : 2023-12-11 Aleksey Dubensky, Ivan Ryzhkov, Zoya Tsokolaeva, Konstantin Lapin, Sergey Kalabushev, Lidia Varnakova, Vladimir Dolgikh
Introduction Laser doppler flowmetry (LDF) allows non-invasive assessment of microvascular functions. The combination of LDF with an occlusion functional test enables study of post-occlusive reactive hyperemia (PORH), providing additional information about vasomotor function, capillary blood flow reserve, and the overall reactivity of the microvascular system. Aim To identify early alterations of PORH
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Site-specific autonomic vasomotor responses and their interactions in rat gingiva Microvasc. Res. (IF 3.1) Pub Date : 2023-12-12 Yunosuke Okada, Toshiya Sato, Syed Taufiqul Islam, Hanako Ohke, Masato Saitoh, Hisayoshi Ishii
Blood flow in the gingiva, comprising the interdental papilla as well as attached and marginal gingiva, is important for maintaining of gingival function and is modulated by risk factors such as stress that may lead to periodontal disease. Marked blood flow changes mediated by the autonomic (parasympathetic and sympathetic) nervous system may be essential for gingival hemodynamics. However, differences
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Changes in renal microcirculation in patients with nephrotic and nephritic syndrome: The role of resistive index Microvasc. Res. (IF 3.1) Pub Date : 2023-12-10 Antonietta Gigante, Chiara Pellicano, Oriana De Marco, Eleonora Assanto, Georgia Sorato, Alberto Palladini, Edoardo Rosato, Silvia Lai, Maurizio Muscaritoli, Rosario Cianci
Background Renal Resistive Index (RRI) is an important and non-invasive parameter of renal damage and it is associated with abnormal microcirculation or to a parenchymal injury. The aim of our study was to compare the RRI in a cohort of patients with renal diseases categorized in three groups: nephrotic syndrome (NS), acute nephritic syndrome (ANS) and patients with urinary abnormalities (UA). Methods
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The SNHG12/microRNA-15b-5p/MYLK axis regulates vascular smooth muscle cell phenotype to affect intracranial aneurysm formation Microvasc. Res. (IF 3.1) Pub Date : 2023-12-09 Wenxian Feng, Hao Liang, Dan Liu, Shiwang Ruan
Objective This research was dedicated to investigating the impact of the SNHG12/microRNA (miR)-15b-5p/MYLK axis on the modulation of vascular smooth muscle cell (VSMC) phenotype and the formation of intracranial aneurysm (IA). Methods SNHG12, miR-15b-5p and MYLK expression in IA tissue samples from IA patients were tested by RT-qPCR and western blot. Human aortic vascular smooth muscle cells (VSMCs)
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Platelet functions in lymphatic filariasis patients Microvasc. Res. (IF 3.1) Pub Date : 2023-12-07 Sushil Surtani, Jyotsna Kailashiya, Mumtaz Ahmad Ansari, Debabrata Dash, Awadesh Kumar Yadav, Ashutosh Kumar
Filariasis is a chronic disease where parasitic worms survive in human hosts even for decades and lead to complications like lymphedema and elephantiasis. Despite the persistent existence of filarial parasites in human hosts, fatal and thrombotic complications are not known, unlike other parasitic diseases like malaria. This suggests that filarial parasites might be affecting the host's platelet functions
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Revisiting hemodynamics and blood oxygenation in a microfluidic microvasculature replica Microvasc. Res. (IF 3.1) Pub Date : 2023-12-07 Rui Dong, Sijia Liu, Yuewu Li, Fan Gao, Keqiang Gao, Chunxiao Chen, Zhiyu Qian, Weitao Li, Yamin Yang
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Goal-directed colloid versus crystalloid therapy and microcirculatory blood flow following ischemia/reperfusion Microvasc. Res. (IF 3.1) Pub Date : 2023-12-02 Christoph R. Behem, Till Friedheim, Hannes Holthusen, Adina Rapp, Timo Suntrop, Michael F. Graessler, Hans O. Pinnschmidt, Sabine H. Wipper, Mirjam von Lucadou, Edzard Schwedhelm, Thomas Renné, Karin Pfister, Wilma Schierling, Constantin J.C. Trepte
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Corrigendum to: “Sodium butyrate and voluntary exercise through activating VEGF-A downstream signaling pathway improve heart angiogenesis in type 2 diabetes” is as follows: 48A, Auf dem Mühlberg, 60599 Frankfurt am Main [Microvasc. Res. Volume 147, May 2023, 104475] Microvasc. Res. (IF 3.1) Pub Date : 2023-11-29 Hassan Dariushnejad, Lale Pirzeh, Neda Roshanravan, Vajihe Ghorbanzadeh
Abstract not available
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Quantitative evaluation of choroidal and retinal microvasculature post-alcohol consumption: A pilot study Microvasc. Res. (IF 3.1) Pub Date : 2023-11-19 Xuenan Zhuang, Guiqin He, Yunkao Zeng, Miaoling Li, Yongyue Su, Xuelin Chen, Yining Zhang, Yuhong Gan, Feng Wen, Xiongze Zhang
Purpose The aim of this study was to assess the impact of acute, heavy alcohol consumption on the ocular microvasculature, providing insight into the largely unexplored response of microvascular structures to excessive drinking. Methods Healthy volunteers in this prospective pilot study were tasked with consuming spirits, wine, and water at different times. Alcohol intake was measured according to
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Investigation of the effects of gestational diabetes and hypertension on retinal and choroidal microvascular circulation using swept-source optical coherence tomography angiography Microvasc. Res. (IF 3.1) Pub Date : 2023-11-17 Mehmet Erkan Doğan, Çisil Erkan Pota
Purpose The aim of this study was to investigate the microvascular changes in the retina and choroid in gestational diabetes mellitus (GDM) and pregnancy-induced hypertension (PIH) and to compare the results with those of healthy pregnant subjects. Methods Twenty-nine pregnant subjects with coexisting GDM and PIH (group 1) and 36 healthy pregnant subjects (group 2) were enrolled in the study. All subjects
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Cerebral arterioles express the laminin subunits α4 and α5 in conjunction with α6β4 integrin, but strongly downregulate laminin α4 during hypoxia-induced arteriogenic remodeling Microvasc. Res. (IF 3.1) Pub Date : 2023-11-16 Arjun Sapkota, Sebok K. Halder, Richard Milner
Previous studies have shown that expression of the endothelial laminin receptor α6β4 integrin in the brain is uniquely restricted to arterioles. As exposure to chronic mild hypoxia (CMH, 8 % O2) stimulates robust angiogenic and arteriogenic remodeling responses in the brain, the goal of this study was to determine how CMH influences cerebrovascular expression of the β4 integrin as well as its potential
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Role of mammalian target of rapamycin in the formation and progression of retinopathy of prematurity-like vascular abnormalities in neonatal rats Microvasc. Res. (IF 3.1) Pub Date : 2023-11-12 Ayuki Nakano, Akane Morita, Shiho Arima, Tohru Nagamitsu, Tsutomu Nakahara
Retinopathy of prematurity (ROP), a retinal disease that can occur in premature infants, can lead to severe visual impairment. In this study, we examined the preventive and therapeutic effects of mammalian target of rapamycin complex 1 (mTORC1) inhibition on abnormal retinal blood vessels in a rat model of ROP. To induce ROP-like vascular abnormalities, rats were subcutaneously treated with KRN633
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Role of protein kinase D1 in vasoconstriction and haemodynamics in rats Microvasc. Res. (IF 3.1) Pub Date : 2023-11-12 Yoh Sugawara, Yusuke Mizuno, Shinya Oku, Yuri Sawada, Takahisa Goto
Aims Protein kinase D (PKD), once considered an effector of protein kinase C (PKC), now plays many pathophysiological roles in various tissues. However, little is known about role of PKD in vascular function. We investigated the role of PKD in contraction of rat aorta and human aortic smooth muscle cells (HASMCs) and in haemodynamics in rats. Methods and results Isometric tension of rat aortic was
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Vasomotion heterogeneity and spectral characteristics in diabetic and hypertensive patients Microvasc. Res. (IF 3.1) Pub Date : 2023-11-03 Liangjing Zhao, Shuhong Liu, Yang Liu, Hui Tang
Vasomotion refers to the spontaneous oscillation of blood vessels within a frequency range of 0.01 to 1.6 Hz. Various disease states, including hypertension and diabetes, have been associated with alterations in vasomotion at the finger, indicating potential impairment of skin microcirculation. Due to the non-linear nature of human vasculature, the modification of vasomotion may vary across different
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Harnessing the benefits of glycine supplementation for improved pancreatic microcirculation in type 1 diabetes mellitus Microvasc. Res. (IF 3.1) Pub Date : 2023-10-31 Bing Wang, Xiaohong Song, Xu Zhang, Yuan Li, Mengting Xu, Xueting Liu, Bingwei Li, Sunjing Fu, Hao Ling, Yingyu Wang, Xiaoyan Zhang, Ailing Li, Mingming Liu
Type 1 diabetes mellitus (T1DM) is predominantly managed using insulin replacement therapy, however, pancreatic microcirculatory disturbances play a critical role in T1DM pathogenesis, necessitating alternative therapies. This study aimed to investigate the protective effects of glycine supplementation on pancreatic microcirculation in T1DM. Streptozotocin-induced T1DM and glycine-supplemented mice
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Differences in peripheral microcirculatory blood flow regulation in chronic kidney disease based on wavelet analysis of resting near-infrared spectroscopy Microvasc. Res. (IF 3.1) Pub Date : 2023-11-04 Jingting Yao, Justin D. Sprick, Jinhee Jeong, Jeanie Park, David A. Reiter
Vascular impairment is closely related to increased mortality in chronic kidney disease (CKD). The objective of this study was to assess impairments in the regulation of peripheral microvascular perfusion in patients with CKD based on time-frequency spectral analysis of resting near-infrared spectroscopy (NIRS) signals. Total hemoglobin (tHb) concentration and tissue saturation index (TSI) signals
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Diagnostic potential of soluble ST2 and D-dimer for Stanford Type B aortic dissection and intramural aortic hematoma Microvasc. Res. (IF 3.1) Pub Date : 2023-11-03 Qian Zhu, Lei Wang, Chao Dai, Yonghua Zhang, Pengpeng Han, Yongxiang Huang, Huan Liu, Lixin Wang
Objective Type B aortic dissection (TBAD) and intramural aortic hematoma (IMH) are common manifestations of Acute Aortic Syndrome (AAS), exhibiting overlapping clinical features. The timely and accurate diagnosis and differentiation between TBAD and IMH are critical for appropriate management. Tumorigenicity 2 (sST2) and D-dimer have been shown to elevate levels in both TBAD and IMH, making them valuable
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Blood-brain barrier permeability in the ischemic stroke: An update Microvasc. Res. (IF 3.1) Pub Date : 2023-10-31 Khiany Mathias, Richard Simon Machado, Solange Stork, David dos Santos, Larissa Joaquim, Jaqueline Generoso, Lucinéia Gainski Danielski, Tatiana Barichello, Josiane Somariva Prophiro, Fabricia Petronilho
Stroke is the second leading cause of death globally and the major cause of long-term disability. Among the types of strokes, ischemic stroke, which occurs due to obstruction of blood vessels responsible for cerebral irrigation, is considered the most prevalent, accounting for approximately 86 % of all stroke cases. This interruption of blood supply leads to a critical pathophysiological mechanism
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Effects of high-intensity interval training on retinal vessel diameters and oxygen saturation in patients with hypertension: A cross-sectional and randomized controlled trial Microvasc. Res. (IF 3.1) Pub Date : 2023-10-27 Cédric Müller, Christoph Hauser, Justin Carrard, Konstantin Gugleta, Timo Hinrichs, Arno Schmidt-Trucksäss, Henner Hanssen, Lukas Streese
Introduction Arterial hypertension is a global healthcare burden that affects macrovascular and microvascular structure and function and can promote vascular end-organ damage. This study aimed 1) to evaluate differences in microvascular health between normotensive individuals and patients with arterial hypertension and 2) to assess the effects of short-term high-intensity interval training (HIIT) on
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Apoptosis-inducing, anti-angiogenic and anti-migratory effects of a dinuclear Pd(II) complex on breast cancer: A promising novel compound Microvasc. Res. (IF 3.1) Pub Date : 2023-10-26 Merve Erkisa Genel, Kaan Adacan, Selin Selvi, Deniz Erol Kutucu, Ayca Uvez, Elif Ilkay Armutak, Abdurrahman Sengul, Engin Ulukaya, Ebru Gurel Gurevin
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Chronic hypoxia-induced alterations of the right ventricular myocardium are not aggravated by alimentary obesity in the mouse Microvasc. Res. (IF 3.1) Pub Date : 2023-10-24 Christian Mühlfeld, Lisa-Marie Bienas, Melanie Bornemann, Julia Schipke
Background and aims Obesity is a risk factor of cardiopulmonary disorders including left and right ventricular dysfunction and pulmonary hypertension (PH), and PH is associated with right ventricular (RV) hypertrophy and failure. Here, we tested the hypothesis that alterations of the RV capillary network under PH induced by chronic hypoxia are aggravated by alimentary obesity, thereby representing
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eIF4A3-mediated circEHMT1 regulation in retinal microvascular endothelial dysfunction in diabetic retinopathy Microvasc. Res. (IF 3.1) Pub Date : 2023-10-13 Yuan Wang, Yongxin Zhang, Yunhao Qu, Shixu Li, Wenqun Xi, Beian Liu, Lin Ye
Background and objective Literature has reported that circular RNAs (circRNAs) are crucially associated with diabetic retinopathy (DR). Furthermore, circEHMT1 has been identified to maintain endothelial cell barrier function. This study aimed to investigate the mechanisms that regulate aberrant circEHMT1 expression and its role in the pathogenesis of DR. Methods In this study, retinal microvascular
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PDGFRA exhibits potential as an indicator of angiogenesis within the tumor microenvironment and is up-regulated in BLCA Microvasc. Res. (IF 3.1) Pub Date : 2023-10-05 Yuyang Hou, Wenjing Du, Qiong Wu, Xinyu Chai, Yinan Wang, Yingqian Mi, Yuan Tian, Mengyan Tang, Jun Li, Dongmei Yan
Bladder cancer (BLCA) is a common type of urogenital malignancy worldwide. The recurrence and metastasis of bladder cancer are closely related to angiogenesis, but the underlying mechanisms are unclear. In this study, we developed a method to predict survival outcomes among BLCA patients, which could be used to guide immunotherapy and chemotherapy. We obtained patient data from The Cancer Genome Atlas
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Pedunculagin and tellimagrandin-I stimulate inflammation and angiogenesis and upregulate vascular endothelial growth factor and tumor necrosis factor-alpha in vivo Microvasc. Res. (IF 3.1) Pub Date : 2023-10-04 Amanda Silva Fernandes, Abel Vieira de Melo Bisneto, Luana Santos Silva, Elisa Flávia Luiz Cardoso Bailão, Clever Gomes Cardoso, Cristiene Costa Carneiro, Suzana da Costa Santos, Lee Chen-Chen
Pedunculagin (PD) and tellimagrandin-I (TL), isolated from Myrciaria cauliflora seeds and Eucaliptus microcorys leaves, respectively, have attracted great attention owing to their relevant biological activities, such as antitumor, antioxidant, and hepatoprotective activities. This study investigated the angiogenic potential of PD and TL using a chick embryo chorioallantoic membrane (CAM) assay. Using
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Platelet and endothelial cell responses under concurrent shear stress and tensile strain Microvasc. Res. (IF 3.1) Pub Date : 2023-10-02 Elisabeth Steadman, Danielle Steadman, David A. Rubenstein, Wei Yin
Thrombosis can lead to significant mortality and morbidity. Both platelets and vascular endothelial cells play significant roles in thrombosis. Platelets' response to blood flow-induced shear stress can vary greatly depending on shear stress magnitude, pattern and shear exposure time. Endothelial cells are also sensitive to the biomechanical environment. Endothelial cell activation and dysfunction
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Astrocytic expression of Yes-associated protein (YAP) regulates retinal neovascularization in a mouse model of oxygen-induced retinopathy Microvasc. Res. (IF 3.1) Pub Date : 2023-09-28 Zhifei Liu, Jieqiong Zhang, Xue Li, Qiumei Hu, Xi Chen, Linlin Luo, Liqianyu Ai, Jian Ye
Pathological neovascularization is the hallmark of many vascular oculopathies. There is still a great deal of uncertainty surrounding retinal neovascularization research. A working hypothesis that astrocytic Yes-associated protein (YAP) act as a key factor in retinal neovascularization was proposed. And our study was conducted to verified this hypothesis. In vivo, we successfully generated mice deficient
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Vessel Metrics: A software tool for automated analysis of vascular structure in confocal imaging Microvasc. Res. (IF 3.1) Pub Date : 2023-09-21 Sean D. McGarry, Cynthia Adjekukor, Suchit Ahuja, Jasper Greysson-Wong, Idy Vien, Kristina D. Rinker, Sarah J. Childs
Images contain a wealth of information that is often under analyzed in biological studies. Developmental models of vascular disease are a powerful way to quantify developmentally regulated vessel phenotypes to identify the roots of the disease process. We present vessel Metrics, a software tool specifically designed to analyze developmental vascular microscopy images that will expedite the analysis
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Microvascular smooth muscle cells exhibit divergent phenotypic switching responses to platelet-derived growth factor and insulin-like growth factor 1 Microvasc. Res. (IF 3.1) Pub Date : 2023-09-15 Marisa A. Bickel, David M. Sherry, Elizabeth C. Bullen, Michaela L. Vance, Ken L. Jones, Eric W. Howard, Shannon M. Conley
Objective Vascular smooth muscle cell (VSMC) phenotypic switching is critical for normal vessel formation, vascular stability, and healthy brain aging. Phenotypic switching is regulated by mediators including platelet derived growth factor (PDGF)-BB, insulin-like growth factor (IGF-1), as well as transforming growth factor-β (TGF-β) and endothelin-1 (ET-1), but much about the role of these factors
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Handheld vital microscopy for the identification of microcirculatory alterations in cervical intraepithelial neoplasia and cervical cancer Microvasc. Res. (IF 3.1) Pub Date : 2023-09-09 Y.P. Latul, C. Ince, N.E. van Trommel, A. van den Brandhof-van den Berg, J.P.W.R. Roovers, A.W. Kastelein
Background Ninety percent of cervical cancer (CC) diagnoses and deaths occur in low and middle-income countries (LMICs). Especially in these countries, where human and material resources are limited, there is a need for real-time screening methods that enable immediate treatment decisions (i.e., ‘see and treat’). Objective To evaluate whether handheld vital microscopy (HVM) enables real-time detection
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Gut microbiota dysbiosis -associated obesity and its involvement in cardiovascular diseases and type 2 diabetes. A systematic review Microvasc. Res. (IF 3.1) Pub Date : 2023-09-09 Nadia Hamjane, Mohcine Bennani Mechita, Naima Ghailani Nourouti, Amina Barakat
Introduction Obesity is a complex, multifactorial disease caused by various factors. Recently, the role of the gut microbiota in the development of obesity and its complications has attracted increasing interest. Purpose This article focuses on the mechanisms by which gut microbiota dysbiosis induces insulin resistance, type 2 diabetes, and cardiovascular diseases linked to obesity, highlighting the
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Costunolide ameliorates angiotensin II-induced atrial inflammation and fibrosis by regulating mitochondrial function and oxidative stress in mice: A possible therapeutic approach for atrial fibrillation Microvasc. Res. (IF 3.1) Pub Date : 2023-09-02 Yushu Liu, Dong Wang, Yimin Jin, Guifang Sun, Qi Lou, Hong Wang, Weimin Li
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Evidence of serial connection between the plasma volume and two interstitial fluid compartments Microvasc. Res. (IF 3.1) Pub Date : 2023-09-01 Robert G. Hahn
Background Kinetic analysis of fluid volume shifts can identify two interstitial fluid compartments with different turnover rates, but how they are connected to the bloodstream is unknown. Methods Retrospective data were retrieved from 217 experiments where 1.5 L of Ringer's solution (mean) had been administered by intravenous infusion over 30 min to awake and anesthetized humans (mean age 40 years)
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Low postoperative perfused vessel density is associated with increased soluble endothelial cell adhesion molecules during circulatory shock after cardiac surgery. Microvasc. Res. (IF 3.1) Pub Date : 2023-08-22 John C. Greenwood, Fatima M. Talebi, David H. Jang, Audrey E. Spelde, Emily K. Gordon, Jiri Horak, Michael A. Acker, Todd J. Kilbaugh, Frances S. Shofer, John G.T. Augoustides, Jan Bakker, Jacob S. Brenner, Vladimir R. Muzykantov, Benjamin S. Abella
Introduction Microcirculatory dysfunction after cardiovascular surgery is associated with significant morbidity and worse clinical outcomes. Abnormal capillary blood flow can occur from multiple causes, including cytokine-mediated vascular endothelial injury, microthrombosis, and an inadequate balance between vasoconstriction and vasodilation. In response to proinflammatory cytokines, endothelial cells
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Neutrophil-to-lymphocyte ratio an inflammatory biomarker, and prognostic marker in heart failure, cardiovascular disease and chronic inflammatory diseases: New insights for a potential predictor of anti-cytokine therapy responsiveness Microvasc. Res. (IF 3.1) Pub Date : 2023-08-24 Artemio García-Escobar, Silvio Vera-Vera, Daniel Tébar-Márquez, Borja Rivero-Santana, Alfonso Jurado-Román, Santiago Jiménez-Valero, Guillermo Galeote, José-Ángel Cabrera, Raúl Moreno
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Vascularization of the adult mouse lung grafted onto the chick chorioallantoic membrane Microvasc. Res. (IF 3.1) Pub Date : 2023-08-23 Kenji Chamoto, Barry C. Gibney, Willi L. Wagner, Maximilian Ackermann, Hassan A. Khalil, Steven J. Mentzer
In the later stages of angiogenesis, the vascular sprout transitions into a functional vessel by fusing with a target vessel. Although this process appears to routinely occur in embryonic tissue, the biologic rules for sprout fusion and lumenization in adult regenerating tissue are unknown. To investigate this process, we grafted portions of the regenerating post-pneumonectomy lung onto the chick chorioallantoic
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Design of in vitro biomimetic experimental system and simulation analysis for transvascular transport of nano-preparation Microvasc. Res. (IF 3.1) Pub Date : 2023-08-23 Guangzhen Zhou, Yan Gao, Yanbin Shi, Shengnan Qiu, Guimei Lin, Xinbing Ding, Wenguang Wang, Yihua Feng, Fei Wang, Jinwei Qiao
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Automated nailfold capillary density measurement method based on improved YOLOv5 Microvasc. Res. (IF 3.1) Pub Date : 2023-08-14 Hao Yin, Zhiwei Wu, An Huang, Jiaxiong Luo, Junzhao Liang, Jianan Lin, Qianyao Ye, Mugui Xie, Cong Ye, Xiaosong Li, Yanxiong Wu
Nailfold capillary density is an essential physiological parameter for analyzing nailfold health; however, clinical images of the nailfold are taken in many situations, and most clinicians subjectively analyze nailfold images. Therefore, based on the improved “you only look once v5” (YOLOv5) algorithm, this study proposes an automated method for measuring nailfold capillary density. The improved technique
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Image-based insilico investigation of hemodynamics and biomechanics in healthy and diabetic human retinas Microvasc. Res. (IF 3.1) Pub Date : 2023-08-12 Kartika Chandra Tripathy, Ashish Siddharth, Ajay Bhandari
Retinal hemodynamics and biomechanics play a significant role in understanding the pathophysiology of several ocular diseases. However, these parameters are significantly affected due to changed blood vessel morphology ascribed to pathological conditions, particularly diabetes. In this study, an image-based computational fluid dynamics (CFD) model is applied to examine the effects of changed vascular