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Regarding: 899 serious adverse events including 13 deaths, 7 strokes, 211 thromboembolic events, and 482 immune reactions: The untold story of cyanoacrylate adhesive closure. Parsi K et al. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2024-03-16 Steve Elias, Nicos Labropoulos, Stephen Black, Antonios Gasparis, Neil Khilnani
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The sonographic features of lymph node venous networks and flow patterns in patients with primary chronic venous disease Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2024-03-12 Gaorui Liu, Jillian Clarke, Yong Liu, Yunwei Zhang, Irwin Mohan
BackgroundOur study aims to enhance the understanding of lymph node venous networks (LNVNs) by summarising their anatomical, sonographic features, and reflux patterns.MethodWe examined 241 legs from 141 patients with primary chronic venous disease (CVD) using duplex ultrasound.ResultsThe findings indicated variations in the shape, size, vascularity, and echogenicity of LNVN. The superficial inguinal
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Outcomes of conservative management in patients with nutcracker syndrome Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2024-03-07 Sabit Sarikaya, Ozge Altas, Mustafa Mert Ozgur, Hakan Hancer, Betul Ayca Ozdere, Tanil Ozer, Mehmet Aksut, Murat Bulent Rabus, Kamile Ozeren Topcu, Tolga Bas, Kaan Kirali
ObjectiveThis study aims to evaluate outcomes in nutcracker syndrome patients with tolerable symptoms and treated conservatively without invasive interventions.MethodsThis prospective study included patients treated conservatively. Promoting weight gain, the endpoint of the study was spontaneous resolution of symptoms.ResultsSixteen patients (75% female and mean age 24.4 ± 3.5 years) underwent conservative
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Femoral vein stenting versus endovenectomy as adjuncts to iliofemoral venous stenting in extensive chronic iliofemoral venous obstruction Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2024-02-28 Mohammed Alsagheer Alhewy, Abdelaziz Ahmed Abdelhafez, Mohammed Hamza Metwally, Ehab Abd elmoneim Ghazala, Alhussein M Khedr, Ahmed Atef Khamis, Hassan Gado, Wael Abdo Abdo Abd-Elgawad, Abdullah El Sayed, Abdelhalim A Abdelmohsen
PurposeTo compare femoral endovenectomy with the creation of an arteriovenous fistula (FE + AVF), versus iliofemoral endovenous stenting with the concurrent extended femoral vein (FV-S) stenting in patients with chronic iliofemoral venous obstruction (IFVO).Materials and MethodsIn a randomized prospective single-center study, 48 received (FV-S), while the other 54 had (FE + AVF).ResultsThere were no
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Selected phlebological abstracts Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2024-02-22 Lowell S. Kabnick, Kathleen Ozsvath, Jorge H. Ulloa
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Common femoral vein wall thickness measurement by Doppler ultrasonography is an accurate diagnostic test for Behçet’s Disease both in supine and standing positions Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2024-02-22 Rabia Ergelen, Seda Kutluğ Ağaçkıran, Haner Direskeneli, Fatma Alibaz-Oner
ObjectivesWe recently reported the first controlled Doppler ultrasonography (US) study demonstrating increased common femoral vein (CFV) thickness in Behçet’s Disease (BD). Standard lower extremity venous Doppler US is performed in erect position. In order to confirm accuracy and applicability of method, we measured CFV thickness in both supine and standing positions in this study.MethodWe included
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Effects of lower limb muscle strengthening on interface pressure in older adults undergoing inelastic compression: Randomized controlled clinical trial Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2024-02-19 Eduardo Simões Da Matta, Giovanni Mosti, Vanessa da Silva Corralo, Glauciano Policeno de Moura, Luciano Branco de Quadros, Clodoaldo Antônio De Sá
ObjectiveTo analyze the effects of lower limb muscle strengthening on interface pressure (IP), static stiffness index (SSI), dynamic stiffness index (DSI), and walking pressure amplitude (WPA) in older adults undergoing inelastic compression therapy.MethodForty-three healthy older adults of both sexes (Age: 66.2 ± 4.4 years) met the eligibility criteria and completed all stages of the study (Resistance
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The study on the relationship between venous ulcer and ankle joint range of motion using ultrasound Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2024-02-13 Jianyu Liao, Zhoupeng Wu
BackgroundChronic venous insufficiency (CVI) often leads to venous ulcers. The relationship between ankle joint range of motion (ROM) and venous ulcers remains under-investigated. This study aims to clarify this relationship using ultrasound imaging.MethodsWe conducted a study on 20 patients with unilateral venous ulcers. Ankle ROM and popliteal vein blood flow were measured using a goniometer and
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The clinical and economic impact of chronic venous insufficiency-associated lymphedema and the prevalence of persistent edema after venous intervention Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2024-02-12 Matthew Genet, Nicos Labropoulos, Antonios Gasparis, Thomas O’Donnell, Kush Desai
ObjectivesTo determine the demographics, outcomes, and healthcare utilization of patients with chronic venous insufficiency-associated lymphedema (CVI-LED) and the prevalence of lymphedema-specific therapy use after venous intervention.MethodsThe IBM MarketScan Commercial and Medicare Claims Databases were examined for patients with CVI-LED. Patient demographics and the use of lymphedema-specific therapy
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Indications, contraindications, side effects, general assessment, and outlook for the future: An International Compression Club survey Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2024-02-01 Mosti Giovanni, Namislo Angrit, Benigni Jean Patrick, Da Matta Eduardo, Partsch Hugo, Schmitz Martin, Abel Martin
BackgroundThe effectiveness of compression therapy (CT) and the best compression modality choice are questioned in many clinical stages of chronic venous disease (CVD). This work aims to obtain information on indications, contraindications, and the best treatment option for CT in different clinical scenarios of CVD.MethodAn online survey was made among members of the International Compression Club
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Third generation of laser (>1900) for endovenous thermoablation (EVLA) of varicose veins: A systematic review and meta-analysis Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2024-01-11 Luca Palombi, Monica Morelli, Dario Bruzzese, Gennaro Quarto
ObjectivesThird generation lasers with longer wavelengths (>1900 nm) have been introduced, in recent years, for the treatment of varicose veins. The possible advantage of the new generation lasers is that they allow complete damage to the vein wall using a lower Power in Watts (W: J/sec) and a lower linear energy density (LEED: J/cm). The aim of this work is to evaluate the results present in the literature
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Performance of an adjustable compression wrap in occupational leg swelling Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2024-01-09 Wassila Taha, Jean Patrick Benigni, Jean François Uhl, Patrick H Carpentier, Pascal Filori, Rashad Bishara
BackgroundEdema in some subjects worsens over time and wraps help to reduce the leg volume.Material and methodsAn adjustable compression wrap was tried on volunteers for 5 h and volumes measured in each limb before and after wrapping using a 3D surface scanner (HandySCAN 3D®) to estimate the volume of the leg. The contralateral leg was used as control.ResultsWe observed a significant decrease in volume
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Laser-sclerosing foam hybrid treatment, a non-tumescent technique for insufficient great saphenous vein ablation Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2024-01-06 Gerardo E Victoria M, Adrian J Rujano A, Giacomo M Zilipo
ObjectiveWe aim to report on the Laser-Sclerosing Foam Hybrid Treatment (LSFHT) and its outcomes when used on patients with great saphenous vein (GSV) insufficiency.MethodsThis was a single center retrospective cohort study on patients with GSV insufficiency that were treated with the LSFHT technique, a surgical procedure that comprises the use of both sclerosing foam and endovenous ablation and avoids
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The anterior saphenous vein. Part 1. A position statement endorsed by the American Vein and Lymphatic Society, the American Venous Forum, and the International Union of Phlebology Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2024-01-04 Mark Meissner, Edward M Boyle, Nicos Labropoulos, Alberto Caggiati, Rachel Drgastin, Suat Doganci, Antonios Gasparis
BackgroundThere is a lack of clarity regarding the terminology of the anterior accessory saphenous vein (AASV) that can impact treatment outcomes. Although use of the word “accessory” implies that the vein is a superficial tributary, evidence supports its role as a truncal vein, similar to the great and small saphenous veins, and warranting a change in terminology.MethodsA multisocietal panel was convened
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CHIVA for dummies Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2024-01-02 Stefano Ricci
BackgroundSparing the Great Saphenous Vein capital for possible arterial substitution and recurrence decrease may be an alternative to current ablation options for Varicose Veins treatment. Conservative surgery of varicose veins (CHIVA) was suggested in 1988 by Franceschi, by limited veins interruptions in strategic points. However, the method did not diffuse due to the need for high Duplex expertise
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Mechanochemical ablation: disappointing long-term anatomic results and worsening symptoms Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2024-01-02 John Blebea
An updated report on the five-year results in the treatment of great saphenous vein incompetence with mechanochemical ablation (MOCA) provides additional evidence for higher rates of anatomic recanalization compared to other treatment modalities and progressive worsening of symptoms with time.
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Valitrack study: Objective evaluation of medical compression wearing time and patient activity with the Accutrack® by Sigvaris Group sensor. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-11-28 Vincent Crébassa,Etienne M Grenier,Geraldine Mme Batot,Eve Matieu-Dupas,Cyril M Chaigneau
INTRODUCTION Objective measurement of compliance is mandatory to evaluate therapeutic effects and clinical benefits of medical compression stockings. This Valitrack study evaluates the Accutrack sensor equipped with an accelerometer. The evaluation is done under controlled and free conditions and during washing. RESULTS Global accordance results are excellent: Sensitivity (98.6%) and specificity (95
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Metabolomic profiling of deep vein thrombosis. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-11-22 Weiguang Jiang,Liu Yang,Yongkang Dang,Xuechao Jiang,Lan Wu,Xiangyang Tong,Jianquan Guo,Yongtao Bao
Deep vein thrombosis (DVT) of the lower extremities is one of the most common peripheral vascular diseases, with significant complications and sequelae. Metabolomics aims to identify small molecules in biological samples. It can serve as a promising method for screening compounds that can be used for early disease detection, diagnosis, treatment response prediction, and prognosis. In addition, high-throughput
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The trends in venous thromboembolism occurrence and prevention after minimally invasive varicose vein surgery. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-11-20 Kirill Lobastov,Maria Shaldina,Athena Matveeva,Anna Kovalchuk,Denis Borsuk,Ilya Schastlivtsev,Leonid Laberko,Alexey Fokin
OBJECTIVES To assess the trends of VTE occurrence and prevention in varicose vein surgery. METHOD The registry-based CAPSIVS trial (NCT03041805) analysis includes results in 1878 lower limbs. The primary outcome is a 28-day symptomatic or asymptomatic DVT revealed with duplex ultrasound. RESULTS Any DVT, including EHIT, was observed in 3.4%, while symptomatic in 0.5%. Prophylactic anticoagulation was
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Localised intravascular coagulation complicating venous malformations: Clinical characterisation. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-11-18 Sophie Blaise,Esaie Soya,Monira Nou,Julie Malloizel-Delaunay,Hélène Thiel,Annouk Bisdorff-Bresson,Christophe Seinturier
OBJECTIVE The International Union of Phlebology recommends measuring at least D-dimer and fibrinogen levels in the diagnosis of extensive extra-truncular venous malformations, with a surface area of 10 cm2 or those which are deep, as well as prior to any interventional procedure. The aim of the study was to characterise venous malformations associated with a possible vascular complication. METHOD This
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Fibrinogen B β promoter polymorphism may not be associated with pulmonary embolism. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-11-18 Wenxiang Chen,Shengbin Han,Jingzhe Xu,Shun Ding,Hongxi Guan
OBJECTIVE A prospective experiment was designed to explore all possible SNPs in the promoter region of fibrinogen B β (FGB) and reveal the influence of these SNPs on susceptibility of pulmonary embolism. METHODS In this 2-year randomized prospective study, we had totally recruited 203 volunteers. 58 PE patients (58 out of 145 VTE patients) and 114 healthy people were taken as case and control objects
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Assessment of skin and associated soft tissue changes with ultrasonography in chronic venous disease. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-11-14 Bhavna Girdhani,Ajay Savlania,Venkata Vineeth Vaddavalli,Arunanshu Behera,Ujjwal Gorsi,Lileshwar Kaman,Raghuraman Soundarajan
OBJECTIVE Chronic venous disease (CVD) is accompanied by a spectrum of skin changes. The aim of this study was to assess skin changes in CVD in different classes of the classifications such as the Clinical-Etiology-Anatomy-Pathophysiology (CEAP) classification using ultrasound (US). METHODS This study was conducted from July 2020 to July 2021 after obtaining approval from Institutional Ethical Committee
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Polymerisation of cyanoacrylates: The effect of sclero-embolic and contrast agents. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-11-09 Joseph Gracé,David Connor,Lourens Bester,Christopher Rogan,Kurosh Parsi
OBJECTIVES The objective is to investigate the interaction of sclero-embolic and contrast agents with the polymerisation of medical grade n-butyl-cyanoacrylates. METHODS An in vitro spectrophotometric absorbance method was developed to detect changes in light transmission to measure n-BCA polymerisation. The initiation and the rate-of-polymerisation of mixtures of n-BCA with sclero-embolic and contrast
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Comparison of one-year outcomes and quality of life between endovenous microwave ablation and high ligation and stripping of the great saphenous vein. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-11-07 Wei Huang,Wei Zeng,Xue-Qing Lin,Li-Feng Zhang,Hai-Jun Wei,Chun-Shui He
INTRODUCTION The objective of this study is to evaluate and compare the effectiveness of endovenous microwave ablation (EMA) and high ligation and strippingn (HLS) of the great saphenous vein (GSV) in the treatment of varicose veins. METHODS We included 182 patients in each EMA and HLS groups. Follow-up outcomes included AVVQ, VCSS, chronic venous insufficiency questionnaire-14 (CIVIQ14) score, clinical
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Core content for venous and Lymphatic Medicine: 2022 revision. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-11-07 N M Khilnani,S M Wasan,P J Pappas,Z Deol,J P Schoonover,S F Daugherty,R R Attaran,T V Cartee,T M Straight,J Fish,J W Granzow,R S Winokur,K R Desai,G Salazar,J Stoughton,K Gibson,A D Jones,J M Lohr,S Vayuvegula,M H Meissner
The core content for a medical specialty outlines the scope of the discipline as well as the categories of knowledge considered essential to practice in the field. It provides a template for the development of curricula for medical school, graduate, and postgraduate education, as well as for creating certification standards. Venous and Lymphatic Medicine (VLM) is a specialty that has benefitted from
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Bidirectional perforators in the lower limb are not physiologically normal: A brief commentary. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-11-03 André M van Rij,Brigid G Hill,Kate N Thomas
The suggestion that bidirectional flow is a normal feature seen in venous perforators of the lower leg has been a longstanding debate. Newer published evidence has changed the perspective on normal perforator flow and is presented here to resolve the misunderstandings and different viewpoints previously held.
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Phenotype and function of smooth muscle cells derived from the human normal great saphenous vein in response to hypoxia. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-11-03 Haibo Chu,Yanyan Qin,Tianzhen Qiu,Shunchang Zhou,Zhang Na,Yanping Sun,Yongbo Xu,Yuxu Zhong
OBJECTIVE The contribution of hypoxia to the pathophysiology of vascular smooth muscle cells (VSMCs) has not yet been fully elucidated. This study evaluated the effect of hypoxia on the phenotype and function of SMCs derived from the human normal great saphenous veins (NGSVs). METHODS Fifteen NGSV tissue samples were collected. SMCs were isolated and cultured. Proliferation, migration, adhesion, senescence
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Interventional treatment for acute iliofemoral deep venous thrombosis. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-11-01 Matthew Tan,Suresh Vedantham,Sriram Narayanan,Kurosh Parsi,Alun H Davies
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Management of isolated distal deep venous thrombosis. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-10-31 Matthew Tan,Fedor Lurie,Dong-Ik Kim,Thomas Wakefield,Kurosh Parsi,Alun H Davies
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Quality of YouTube® videos on thrombolysis and thrombectomy for deep venous thrombosis. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-10-30 Qi Yan,Aashish Rajesh,Mark G Davies
OBJECTIVE YouTube® has gained popularity as an unofficial educational resource for surgical trainees, but its content's quality and educational value remain to be evaluated. The aim of this study is to analyze the current content on these techniques for lower extremity DVT (LEDVT) on YouTube®. METHODS A search was performed on YouTube® using 13 search terms in August 2022 on a clear-cached browser
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899 serious adverse events including 13 deaths, 7 strokes, 211 thromboembolic events, and 482 immune reactions: The untold story of cyanoacrylate adhesive closure. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-10-30 Kurosh Parsi,Lois Zhang,Mark S Whiteley,Selene Vuong,Mina Kang,Nikita Naidu,Joseph Grace,David E Connor
OBJECTIVE The aim was to retrieve and analyse the serious adverse events of venous occlusion systems used in cyanoacrylate adhesive closure (CAC) submitted to regulatory agencies. METHODS The Total Product Life Cycle (TPLC) database of the US Food and Drug Administration (FDA), the Database of Adverse Event Notifications (DAEN) of the Australian Therapeutic Goods Administration (TGA), and the Yellow
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Application of complete decongestive therapy after lymphaticovenular anastomosis of the lower limb combined with liposuction-A retrospective study research. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-10-28 Xuchuan Zhou,Gejia Ma,Xi Qi,Aoshuang Qin,Bin Liu
BACKGROUND Complete decongestive therapy (CDT) is a conservative treatment for lymphedema that combines interventions and lifestyle changes. We evaluated the application of CDT after lymphaticovenular anastomosis (LVA) of the lower limb combined with liposuction. METHODS A total of 55 patients who underwent LVA of the lower limb combined with liposuction from January 2021 to July 2022 were enrolled
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Factors limiting women's adherence to venous thromboembolism prophylaxis after cesarean section in the Gaza Strip: A cross-sectional study. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-10-17 Belal Aldabbour,Ola Abu Sidgh,Israa Haboush,Eman Jalhum,Shimaa Alsmary,Sara Irheem,Samah Elamassie,Mohammad Zimmo,Mohammad Dabour Asad
OBJECTIVES We evaluate the rates and limitations of women's adherence to low molecular weight heparin (LMWH) after cesarean section (CS) in the Gaza Strip. METHODS Women who underwent CS were recruited consecutively. Communication offered to women, adherence to Venous thromboembolism (VTE), and its limiting factors were surveyed. RESULTS 281 women participated (mean age 27.9 years). 51.95% fully adhered
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A novel view to varicose veins pathogenesis: Proteomic profiling suggests a pivotal role of extracellular matrix degradation. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-10-16 Sigitas Urbonavicius,Reshaabi Srinanthalogen,Jes Sandermann,Mindaugas Valius,Algirdas Kaupinis,Maja Ludvigsen
INTRODUCTION Although morphological and anatomical studies indicate that venous wall weakening and subendothelial fibrosis characterize varicose veins (VV), the pathogenesis of VV remains poorly understood. The aim of this study is to obtain protein expression profiles in patients with VV and thereby get a step closer to understanding the pathogenesis of VV. METHODS Specimens were obtained from total
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Response to - Letter to the editor 'Transparietal diffusion of polidocanol: Potential complication of sclerotherapy?' Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-10-11 Mina Kang,Kurosh Parsi
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Long-term results and predictors of failure after mechanochemical endovenous ablation in the treatment of primary great saphenous vein incompetence. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-09-15 Marianne E Witte,Suzanne Holewijn,Daphne van der Veen,Michel Mpj Reijnen,Clark J Zeebregts
BACKGROUND Mechanochemical endovenous ablation (MOCA) was introduced to treat superficial venous insufficiency of the lower leg with less pain and haematoma. Long-term outcome is still lacking. The purpose was to report long-term outcome and to analyse possible predictors for failure. METHODS The study was a retrospective pooled analysis of two prospective cohorts previously reported, but with prolonged
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Clinical observations in treatment of lower extremity varicose veins with trigger points acupuncture. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-09-14 Lin Liu,Zong-Hui Wu,Qiang-Min Huang,Qing-Guang Liu,Li-Na Wang,Xiao-Hong Jin
OBJECTIVES To observe the effect of the acupuncture of myofascial trigger points (MTrPs) in the treatment of lower extremity varicose veins (LEVVs). METHODS Overall, 260 patients with LEVVs participated in this study. LEVVs were selected based on diagnostic criteria of Clinical, Etiology, Anatomy, and Pathophysiology levels 2-5 and classified into six types on the basis of their anatomical positions
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A new compression stocking with well-defined pressure-a randomized controlled pilot study. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-09-11 Ulrika Källman,Melina Fallenius,Carina Bååth
BACKGROUND To evaluate an innovative class I compression stocking with predetermined uniform pressure in comparison to a graduated class III compression stocking system, regarding edema reduction, interface pressure, and patient comfort. METHOD Twenty-five patients with chronic venous disease, were randomized: 12 to investigational stocking, 13 to comparator stocking. Data collected at baseline and
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Implementation of a varicose vein module added to Swedvasc, the Swedish National Registry for vascular surgery. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-09-07 Lena Blomgren
OBJECTIVES The addition of a varicose veins (VV) module to the existing Swedish National Registry for Vascular Surgery (Swedvasc) and its impact on quality of care were evaluated. METHODS Vascular departments and private VV clinics were invited to enter data from 2016. RESULTS Registrations were approximately 10,000 yearly but dropped to 5390 in 2022 when a fee was introduced for private clinics due
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Development and validation of a graduated compression stockings adherence scale. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-08-31 Wen-Tao Yang,Hua-Liang Ren,Kai Zheng,Zhen-Yi Jin,Jia-Hao Wen,Sheng-Xing Wang,Wang-De Zhang,Chun-Min Li
OBJECTIVE Compression therapy with the use of graduated compression stockings (GCSs) is a common treatment strategy for chronic venous disease (CVD). However, there is no uniform and objective standard to assess adherence to the use of GCSs. The aim of this study is to develop and validate a GCS Compliance Scale (GCSAS) to fill gaps in internationally recognized comprehensive scales and provide a useful
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Impact of lymphedema in the management of venous leg ulcers. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-08-30 Tina Moon,Thomas F O'Donnell,Derek Weycker,Mark Iafrati
INTRODUCTION Lymphedema (LED) in patients with venous leg ulcers (VLU) [VLU+LED] can impair ulcer healing and predispose to cellulitis. There is little data, however, demonstrating how lymphatic dysfunction may impact the clinical course, treatment, and healthcare expenditures for VLU+LED versus VLU-LED patients. OBJECTIVE To determine how lymphatic dysfunction might influence treatment and expenditures
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Direct oral anticoagulants for deep vein thrombosis among patients with hereditary thrombophilia-A cohort study. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-08-30 George Galyfos,Alexandros Chamzin,Georgios Charalampopoulos,Nikolaos Liasis,Frangiska Sigala,Konstantinos Filis
OBJECTIVES to evaluate direct oral anticoagulants (DOACs) in patients with hereditary thrombophilia and deep venous thrombosis (DVT). METHODS This is a retrospective observational study. RESULTS In total, 45 patients were treated between 01/2012 and 12/2022 (mean follow-up: 1.5 +/- 0.3 years). The most frequent thrombophilias were heterozygous V Leiden (20%), heterozygous MTHFR C677T (37.8%), heterozygous
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Transparietal diffusion of polidocanol: Potential complication of sclerotherapy? Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-08-29 Albert-Adrien Ramelet,Simon Bossart
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Comparison of cyanoacrylate closure and radiofrequency ablation for the treatment of small saphenous veins. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-08-29 Oguz Arslanturk,Fatih Gumus
BACKGROUND The objective of this study was to compare the early and mid-term results of radiofrequency ablation and cyanoacrylate ablation used in the treatment of small saphenous insufficiency. METHODS A total of 84 patients with isolated small saphenous vein insufficiency who underwent either cyanoacrylate ablation (CA) (Group 1, n = 40) or radiofrequency ablation (RFA) (Group 2, n = 44) were analyzed
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Pigmentation of lower limbs: Contribution of haemosiderin and melanin in chronic venous insufficiency and related disorders. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-08-29 Lois Zhang,Kate Ng,James P Pham,Samuel Thoo,Anes Yang,Mina Kang,David Connor,Steven Kossard,Kurosh Parsi
BACKGROUND To determine the composition of skin pigmentation in chronic venous insufficiency (CVI) and other less common vascular conditions of lower limbs. METHODS Forty-five skin biopsies were obtained from 17 patients. Samples were taken from pigmented regions and compared with control non-lesional samples from the same patient. Perl's Prussian Blue was used to identify haemosiderin and Schmorl's
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Punch grafting for the treatment of ulcerated atrophie blanche. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-08-25 Ana Orbea Sopeña,Elena Conde Montero
Case report: A 79-year-old woman presented with a large painful ulcer on the lateral aspect of her left leg over a 6-month period and was diagnosed of ulcerated atrophie blanche. On an outpatient basis punch grafting was performed and 3 weeks after, complete epithelization was achieved. Discussion: Ulcerated atrophie blanche is a misdiagnosed disorder with painful lesions and, consequently, a high
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Biomarkers and the post-thrombotic syndrome: A systematic review of biomarkers associated with the occurrence of the post-thrombotic syndrome after lower extremity deep venous thrombosis. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-08-24 Aksel Nathan Harbsmeier,Izzet Altintas,Kasper Iversen,Ove Andersen,Jan O Nehlin
INTRODUCTION Post-thrombotic syndrome (PTS) is a frequent chronic complication of deep venous thrombosis (DVT). Biomarkers are potentially valuable clinical tools for handling PTS. The purpose of this review was to examine which biomarkers are associated with the development of PTS in adults with lower extremity DVT. METHODS We performed a systematic review of all English language prospective studies
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The relationship between inspiratory muscle strength, venous refilling time, disease severity, and functional capacity in patients with chronic venous insufficiency. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-08-10 Gamze Aydin,Ipek Yeldan,Ahmet Akgul
BACKGROUND Our aim is to evaluate the relationship between inspiratory muscle strength and venous refilling time, disease severity, and functional capacity in patients with chronic venous insufficiency (CVI). METHODS Sixty-one patients (49 female, aged 20-65 ) were enrolled in the study. The demographic characteristics of the patients were questioned. All patients were assessed with maximum inspiratory
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Durability and efficacy of the ELVeS® Radial® 2ring slim fiber for multiple ablations. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-08-06 Jürgen Verbist,Veerle Laeremans,Fien Gryffroy,Wouter Van den Eynde,Caroline Heerinckx,Dorien Haesen
OBJECTIVES To prove that the ELVeS® Radial® 2ring slim fiber (Biolitec AG, Wien, Austria) is safe and effective, with a reliable fiber durability. METHODS This prospective, non-randomized, registry recruited patients with venous incompetence of the great saphenous vein, with or without concomitant incompetence of the small, anterior accessory and posterior accessory saphenous veins. Anatomic success
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Low concentration of sodium tetradecyl sulfate and hypertonic glucose solution for the treatment of telangiectasia: A prospective randomized clinical trial. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-07-30 Oksana V Bukina,Aleksandr A Sinitsyn,Oksana I Efremova,Andrey V Pelevin
OBJECTIVES This study aimed to compare telangiectasias disappearance after sclerotherapy with hypertonic glucose (HG) and different concentrations of sodium tetradecyl sulfate (STS). METHODS Women aged 18-70 years with telangiectasias were included. The primary efficacy endpoint was telangiectasia disappearance. The clearing of vessels was assessed using a six-point scale (from 0 to 5). RESULTS A total
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The relationship between pes planus and venous insufficiency. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-07-30 Şahika Burcu Karaca,Hatice Ağır
INTRODUCTION The presence of pes planus may be responsible for the disorder of venous return during ambulation. Our aim in this study is to reveal that the risk of venous insufficiency may be increased in patients with pes planus. METHODS A total of 59 patients with 29 bilateral pes planus and 30 normal arches included in the study. Djian Annonier angle measurement, bilateral lower extremity venous
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Analysis of the postoperative hemodynamic changes in varicose vein surgery related with small saphenous vein reflux. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-07-21 Joon-Kee Park,Shin-Young Woo,Shin-Seok Yang,Dong-Ik Kim
PURPOSE To evaluate the postoperative hemodynamic changes in varicose vein surgery related with SSV reflux using APG. METHODS Totals of 181 limbs and 178 patients who underwent high ligation and stripping (HLS) (87 limbs), radiofrequency ablation (RFA) (43 limbs), or endovenous laser ablation (EVLA) (51 limbs) for SSV reflux from 1995 to 2022 were enrolled. We measured venous volume (VV), venous filling
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Complications of cyanoacrylate adhesive closure therapy in chronic venous insufficiency: A single center, single-surgeon study. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-07-20 Ercan Keles
OBJECTIVES In this study, we present the complication data of patients we treated for chronic venous insufficiency (CVI) with cyanoacrylate adhesive closure (CAC) therapy for 2 years. METHODS Complications of 382 CAC procedures performed by the same surgeon were reviewed retrospectively. RESULTS Independent of patients, depending on the payment system of the state; two hundred twenty-three (58.4%)
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MiR-128-3p promotes the progression of deep venous thrombosis through binding SIRT1. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-07-19 Jinan Han,Wanjiang Hao,Yanping Ma,Yanqiu Hou
OBJECTIVES This research aimed to study the effect of microRNA-128-3p (miR-128-3p) on deep venous thrombosis (DVT). METHOD The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, Transwell chamber method, and flow cytometry technique were used in the cell experiments. Potential interconnection between miR-128-3p and silent information regulator sirtuin 1 (SIRT1) was revealed by
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The impact of invasive treatment of superficial venous insufficiency of the lower extremities on cardiac functions. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-07-17 Fatih Koca,Fatih Levent,Ahmet Burak Tatlı,Mehmet Demir,Erhan Tenekecioglu
OBJECTIVE The aim of the study was to investigate the effect of invasive treatment for chronic venous insufficiency (CVI) on cardiac hemodynamics. METHODS Fifty three patients diagnosed with saphenofemoral junction or great saphenous vein insufficiency in a level above C3 according to Clinical-Etiology-Anatomy-Pathophysiology classification were included in the study. All the patients underwent 2D
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A readability analysis of patient education materials about chronic venous disease provided by professional vascular societies. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-07-16 Jianyu Liao,Zhoupeng Wu,Jichun Zhao
BACKGROUND Professional vascular societies and forums have disseminated patient information on education materials about chronic venous disease (CVD) via their official websites. While online patient education material is readily available with an Internet connection, its practical utility may be limited for patients with low health literacy. METHODS Six readability measures were used to evaluate the
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A comparison of patient-reported outcome measures following technical success and technical failure in the treatment of great saphenous vein incompetence using ClariVein: A subanalysis of a multicenter randomized controlled trial comparing 2% and 3% polidocanol. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-07-12 Tamana Alozai,Yee Lai Lam,Michiel A Schreve,André Aea de Smet,Anco C Vahl,Liesbeth C Terlouw-Punt,Çağdaş Ünlü,Cees Ha Wittens
OBJECTIVE This study aimed to compare patient-reported outcomes after technical success (TS) and technical failure (TF) in treating great saphenous vein incompetence (GSV) with ClariVein. METHODS A subanalysis of a previous trial was conducted on symptomatic GSV incompetence patients who received ClariVein treatment with 2% or 3% polidocanol (POL) and were followed for 6 months. Blinding was implemented
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Clinical efficacy of ZelanteDVT™ catheter rheolytic thrombectomy in the single-session treatment of patients with subacute deep venous thrombosis. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-07-12 Da Li,Xiaosong Zhang,Yusheng Wang,Hao Tang,He Huang,Xiaomin Huang,Honggang Zhang
OBJECTIVE To evaluate the clinical efficacy and safety of novel ZelanteDVT™ catheter rheolytic thrombectomy in the single-session endovascular management of subacute deep venous thrombosis (DVT). METHODS A retrospective study was performed on 31 patients with subacute DVT who underwent ZelanteDVT™ catheter rheolytic thrombectomy. Procedure data, associated complications, and venous patency score were
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Biomechanical alterations in lower limb lymphedema: Implications for walking ability and rehabilitation. Phlebol. J. Venous Dis. (IF 1.7) Pub Date : 2023-07-06 Roberto Tedeschi
BACKGROUND Lymphedema is a chronic progressive disease that results in interstitial edema in the limbs, and to a lesser extent in the genitals and face, due to damage to the lymphatic system. METHODS Research was conducted between July 2022 and September 2022 in biomedical databases: PubMed, Cochrane Central Register of Controlled Trials (Cochrane Library), and PEDro. RESULTS Two studies showed that