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Endothelin Receptor Blockade Improves Cerebral Blood Flow-Mediated Dilation in a Mouse Model of Alzheimer's Disease. J. Vasc. Res. (IF 1.7) Pub Date : 2023-11-17 Daniel Henrion,Philippe Bonnin,Emilie Vessieres,Anne-Laure Guihlot,Marc Iglarz,Bernard I Lévy
INTRODUCTION Cerebral blood flow (CBF) is reduced in patients with Alzheimer's disease (AD). Flow-mediated dilation (FMD), which plays a key role in the regulation of blood flow, is attenuated by endothelin-1. We hypothesized that endothelin receptor blockade may improve CBF in AD. METHODS We investigated cerebrovascular reactivity in a mouse model of AD (APP-PS1; 5-6-month-old male subjects). We assessed
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Protease-Activated Receptor 2 Controls Vascular Smooth Muscle Cell Proliferation in Cyclic AMP-Dependent Protein Kinase/Mitogen-Activated Protein Kinase Kinase 1/2-Dependent Manner. J. Vasc. Res. (IF 1.7) Pub Date : 2023-09-29 Madison D Williams,Michael T Bullock,Sean C Johnson,Nathan A Holland,Danielle M Vuncannon,Joani Zary Oswald,Shaquria P Adderley,David A Tulis
INTRODUCTION Cardiovascular disorders are characterized by vascular smooth muscle (VSM) transition from a contractile to proliferative state. Protease-activated receptor 2 (PAR2) involvement in this phenotypic conversion remains unclear. We hypothesized that PAR2 controls VSM cell proliferation in phenotype-dependent manner and through specific protein kinases. METHODS Rat clonal low (PLo; P3-P6) and
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Regulation of Skeletal Muscle Resistance Arteriolar Tone: Integration of Multiple Mechanisms. J. Vasc. Res. (IF 1.7) Pub Date : 2023-09-28 Brayden D Halvorson,Yuki Bao,Aaron D Ward,Daniel Goldman,Jefferson C Frisbee
INTRODUCTION Physiological system complexity represents an imposing challenge to gaining insight into how arteriolar behavior emerges. Further, mechanistic complexity in arteriolar tone regulation requires that a systematic determination of how these processes interact to alter vascular diameter be undertaken. METHODS The present study evaluated the reactivity of ex vivo proximal and in situ distal
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Cx43 Facilitates Mesenchymal Transition of Endothelial Cells Induced by Shear Stress. J. Vasc. Res. (IF 1.7) Pub Date : 2023-09-06 En Zhou,Jing Zhou,Changlong Bi,Zongqi Zhang
OBJECTIVES This study aimed to determine the function of Cx43 in the endothelial-to-mesenchymal transition (EndMT) process of endothelial cells (ECs) and to explore the potential signaling pathways underlying these functions. METHODS ECs were extracted from rat aorta. ECs were transfected with Cx43 cDNA and Cx43 siRNA and then exposed to 5 or 12 dyne/cm2. Immunofluorescence staining was used to detect
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Emodin Inhibits the Indoxyl Sulfate-Induced trans-Differentiation of Vascular Smooth Muscle Cells through Upregulating Thrombospondin-1. J. Vasc. Res. (IF 1.7) Pub Date : 2023-09-05 Weidong Zhang,Jing Chen,Xiao Tan,Pan Zhang,Xialian Xu,Xiaoqiang Ding,Shuan Zhao,Shi Jin
BACKGROUND Indoxyl sulfate (IS) is a protein-bound uremic toxin with vascular toxicity. The primary cause of death in uremic patients on maintenance hemodialysis is vascular disease, and it had been reported that vascular smooth muscle cells (VSMCs) trans-differentiation (VT) plays a vital role in the context of vascular diseases, but the underlying mechanisms remain obscure. Thrombospondin-1 (TSP-1)
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RhoA/ROCK Signaling Is Involved in Pathological Retinal Neovascularization. J. Vasc. Res. (IF 1.7) Pub Date : 2023-09-01 Fen Tang,Kongqian Huang,Biyan Peng,Wen Deng,Ning Su,Fan Xu,Mingyuan Zhang,Haibin Zhong
OBJECTIVE The aim of the study was to evaluate the effect of the RhoA/ROCK inhibitor Fasudil on retinal neovascularization (NV) in vivo and angiogenesis in vitro. METHODS C57BL/6 was used to establish an OIR model. First, RhoA/ROCK expression was first examined and compared between OIR and healthy controls. Then, we evaluated the effect of Fasudil on pathological retinal NV. Whole-mount retinal staining
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Isolation and Cultivation of Vascular Smooth Muscle Cells from the Mouse Circle of Willis. J. Vasc. Res. (IF 1.7) Pub Date : 2023-08-29 Wei Chang,Yajuan Li,Fengzhou Liu,Kehai Zang,Peiran Zhang,Shuai Qu,Jingyu Zhao,Junhui Xue
INTRODUCTION Culturing cerebrovascular smooth muscle cells (CVSMCs) in vitro can provide a model for studying many cerebrovascular diseases. This study describes a convenient and efficient method to obtain mouse CVSMCs by enzyme digestion. METHODS Mouse circle of Willis was isolated, digested, and cultured with platelet-derived growth factor-BB (PDGF-BB) to promote CVSMC growth, and CVSMCs were identified
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A Preliminary Discussion on the Safety of Mild Therapeutic Hypothermia in Target Vessels after Endovascular Intervention in Acute Large Vessel Occlusion Cerebral Infarction. J. Vasc. Res. (IF 1.7) Pub Date : 2023-08-28 Jiang Li,Shaonian Tang,Juanli Liu,Wenlin He,Jinjin Yan,Zhiyong Huang,Xuesong Li
INTRODUCTION The aim of this study was to discuss the safety of rapid administration of 4°C hypothermic normal saline into the occluded vessels using an intra-arterial catheter to induce mild hypothermia following endovascular thrombectomy in patients with acute large vessel occlusion cerebral infarction. METHODS We selected 78 patients with acute large vessel occlusion cerebral infarction who underwent
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FNDC5 Attenuates Atherosclerotic Plaque Formation and Regulates PPARα/HO-1 in ApoE-/- Mice. J. Vasc. Res. (IF 1.7) Pub Date : 2023-08-16 Bo Zhou,Xiang Wang,Yao Wang,Danan Liu
INTRODUCTION This study attempted to observe the role of fibronectin type III domain-containing protein 5 (FNDC5) in atherosclerosis development and the underlying mechanism. METHODS After being fed a high-fat diet (HFD), ApoE-/- mice were injected with saline, control adenovirus (Ad-vector), or FNDC5 overexpressing adenovirus (Ad-FNDC5). ApoE-/- mice fed with a chow diet were considered the control
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What Is Next for Connexin and Pannexin? J. Vasc. Res. (IF 1.7) Pub Date : 2023-08-16 Timothy M Sveeggen,Anna Kosmach,Pooneh Bagher
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Vascular Dysfunction in Polycystic Kidney Disease: A Mini-Review. J. Vasc. Res. (IF 1.7) Pub Date : 2023-08-03 Melissa R Dennis,Paulo W Pires,Christopher T Banek
Polycystic kidney disease (PKD) is one of the most common hereditary kidney diseases, which is characterized by progressive cyst growth and secondary hypertension. In addition to cystogenesis and renal abnormalities, patients with PKD can develop vascular abnormalities and cardiovascular complications. Progressive cyst growth substantially alters renal structure and culminates into end-stage renal
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Tortuosity and Proximal-Specific Hemodynamics Associated with Plaque Location in the Carotid Bulb Stenosis. J. Vasc. Res. (IF 1.7) Pub Date : 2023-07-27 Lei Ren,Rongjie Xu,Chenxi Zhao,Wenfei Li,Shu Wang,Chen Cao,Yan Gong,Jinxia Zhu,Xuequan Feng,Bo Ren,Shuang Xia
BACKGROUND Atherosclerotic plaque locations in the carotid bulb increasingly have been found to be associated with patterns of ischemic lesions and plaque progression. However, the occurrence of carotid bulb plaque is a complex process. We aimed to investigate plaque characteristics and geometric and hemodynamic parameters among patients with body and apical plaques of the carotid bulb and to identify
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Endothelial Progenitor Cells and Macrophage Subsets Recruitment in Postischemic Mouse Hind Limbs. J. Vasc. Res. (IF 1.7) Pub Date : 2023-06-19 Victor Lamin,Arul M Mani,Madhu V Singh,Ayotunde O Dokun
INTRODUCTION Peripheral arterial disease (PAD) occurs from atherosclerotic obstruction of arteries in the lower extremities. Restoration of perfusion requires angiogenesis and arteriogenesis through migration and differentiation of endothelial progenitor cells (EPCs) and macrophages at the site of injury. The time of recruitment has not been fully investigated. In this study, we investigated the infiltration
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Connexin 40-Mediated Regulation of Systemic Circulation and Arterial Blood Pressure. J. Vasc. Res. (IF 1.7) Pub Date : 2023-06-16 Mónica Márquez,Matías Muñoz,Alexandra Córdova,Mariela Puebla,Xavier F Figueroa
Vascular system is a complex network in which different cell types and vascular segments must work in concert to regulate blood flow distribution and arterial blood pressure. Although paracrine/autocrine signaling is involved in the regulation of vasomotor tone, direct intercellular communication via gap junctions plays a central role in the control and coordination of vascular function in the microvascular
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Methyl Palmitate Modulated NMDA-Induced Cerebral Hyperemia in Hypertensive Rats. J. Vasc. Res. (IF 1.7) Pub Date : 2023-06-07 Chun-Kai Hsu,Shang-Jen Chang,Li-Yi Lim,Hsi-Hsien Chang,Stephen Shei-Dei Yang
N-methyl-D-aspartate (NMDA) receptors were found to be dysfunctional in hypertensive rats. Methyl palmitate (MP) has been shown to diminish the nicotine-induced increase in blood flow in the brainstem. The aim of this study was to determine how MP modulated NMDA-induced increased regional cerebral blood flow (rCBF) in normotensive (WKY), spontaneously hypertensive (SHR), and renovascular hypertensive
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Validation of an ex vivo Flow Model Including Magnetic Resonance Imaging to Study the Effects of Endovascular Treatments on the Arterial Wall J. Vasc. Res. (IF 1.7) Pub Date : 2023-03-07 Raúl Devia Rodriguez, Eline Huizing, Çağdaş Ünlü, Frank F.J. Simonis, Reinoud P.H. Bokkers, Jean-Paul P.M. de Vries, Richte C.L. Schuurmann, Dalibor Nakladal, Hendrik Buikema, Jan-Luuk Hillebrands, Henri G.D. Leuvenink
Endovascular revascularization is the preferred treatment for peripheral arterial disease. Restenosis often occurs as a response to procedure-induced arterial damage. Reducing vascular injury during endovascular revascularization may improve its success rate. This study developed and validated an ex vivo flow model using porcine iliac arteries, obtained from a local abattoir. Twenty arteries (of 10
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Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists J. Vasc. Res. (IF 1.7) Pub Date : 2023-02-24
Research involving human subjects in ambulatory settings is a critical link in the chain comprising translational research, spanning preclinical research to human subject and patient cohort studies. There are presently a wide array of techniques and approaches available to investigators wishing to study blood flow, perfusion, and vascular structure and function in human subjects. In this multi-sectioned
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Connexin 43 across the Vasculature: Gap Junctions and Beyond J. Vasc. Res. (IF 1.7) Pub Date : 2022-12-13 Meghan W. Sedovy, Xinyan Leng, Melissa R. Leaf, Farwah Iqbal, Laura Beth Payne, John C. Chappell, Scott R. Johnstone
Connexin 43 (Cx43) is essential to the function of the vasculature. Cx43 proteins form gap junctions that allow for the exchange of ions and molecules between vascular cells to facilitate cell-to-cell signaling and coordinate vasomotor activity. Cx43 also has intracellular signaling functions that influence vascular cell proliferation and migration. Cx43 is expressed in all vascular cell types, although
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Follicle-Stimulating Hormone Accelerates Atherosclerosis by Activating PI3K/Akt/NF-κB Pathway in Mice with Androgen Deprivation J. Vasc. Res. (IF 1.7) Pub Date : 2022-11-22
Objective: Follicle-stimulating hormone (FSH) level changes may be another reason for increasing the risk of cardiovascular disease. In this study, we aimed to investigate the role of FSH in atherosclerosis and its underlying mechanism. Methods: ApoE−/− mice were divided into 4 groups, namely, the sham group, bilaterally orchidectomized group, FSH group, and testosterone-only group. Blood lipid and
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What Went Wrong with VEGF-A in Peripheral Arterial Disease? A Systematic Review and Biological Insights on Future Therapeutics J. Vasc. Res. (IF 1.7) Pub Date : 2022-11-15 Stavroula L. Kastora, Jonathan Eley, Martin Gannon, Ross Melvin, Euan Munro, Sotirios A. Makris
Background: Of the 200 million patients worldwide affected by peripheral arterial disease (PAD), 4% will inevitably require major limb amputation. Previous systematic reviews presented a conflicting body of evidence in terms of vascular endothelial growth factor (VEGF) family member effects upon PAD natural progression. Despite that, modulation of intrinsic angiogenesis mechanisms targeting the VEGF
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Smooth Muscle Cell Relaxation Worsens Aortic Dilatation and Clinical Presentation in a BAPN/Angiotensin II-Induced Aortic Dissection Model in Rats J. Vasc. Res. (IF 1.7) Pub Date : 2022-11-10 Quentin Pellenc, Sandy El Bitar, Arthur Darmon, Sébastien Dupont, Jean-Baptiste Michel, Guillaume Jondeau
Introduction: Beta-aminopropionitrile (BAPN) administration is a chemically induced model for preclinical aortic pathologies research. Angiotensin II (AngII) has been widely used to promotes aortic dissections in mice. Here, we provide insight on a modified aortic dissection model in rats. The effect of smooth muscle cell (SMC) relaxation with vasodilators is studied in this model. Methods: Forty Sprague-Dawley
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Potential Implications of Exercise Training on Pannexin Expression and Function J. Vasc. Res. (IF 1.7) Pub Date : 2022-11-10 Brent Wakefield, Silvia Penuela
Pannexins (PANX1, 2, 3) are channel-forming glycoproteins that are expressed throughout the cardiovascular and musculoskeletal system. The canonical function of these proteins is to release nucleotides that act as purinergic signalling at the cell membrane or Ca2+ channels at the endoplasmic reticulum membrane. These two forms of signalling are essential for autocrine and paracrine signalling in health
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The Microvascular-Lymphatic Interface and Tissue Homeostasis: Critical Questions That Challenge Current Understanding J. Vasc. Res. (IF 1.7) Pub Date : 2022-10-31 Arinola O. Lampejo, Michiko Jo, Walter L. Murfee, Jerome W. Breslin
Lymphatic and blood microvascular networks play critical roles in the clearance of excess fluid from local tissue spaces. Given the importance of these dynamics in inflammation, tumor metastasis, and lymphedema, understanding the coordinated function and remodeling between lymphatic and blood vessels in adult tissues is necessary. Knowledge gaps exist because the functions of these two systems are
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The Microvascular-Lymphatic Interface and Tissue Homeostasis: Critical Questions That Challenge Current Understanding J. Vasc. Res. (IF 1.7) Pub Date : 2022-10-31
Lymphatic and blood microvascular networks play critical roles in the clearance of excess fluid from local tissue spaces. Given the importance of these dynamics in inflammation, tumor metastasis, and lymphedema, understanding the coordinated function and remodeling between lymphatic and blood vessels in adult tissues is necessary. Knowledge gaps exist because the functions of these two systems are
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Stromal Vascular Fraction Reverses the Age-Related Impairment in Revascularization following Injury J. Vasc. Res. (IF 1.7) Pub Date : 2022-09-08 Gabrielle Rowe, David S. Heng, Jason E. Beare, Nicholas A. Hodges, Evan P. Tracy, Walter L. Murfee, Amanda J. LeBlanc
Adipose-derived stromal vascular fraction (SVF) has emerged as a potential regenerative therapy, but few studies utilize SVF in a setting of advanced age. Additionally, the specific cell population in SVF providing therapeutic benefit is unknown. We hypothesized that aging would alter the composition of cell populations present in SVF and its ability to promote angiogenesis following injury, a mechanism
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Stromal Vascular Fraction Reverses the Age-Related Impairment in Revascularization following Injury J. Vasc. Res. (IF 1.7) Pub Date : 2022-09-08
Adipose-derived stromal vascular fraction (SVF) has emerged as a potential regenerative therapy, but few studies utilize SVF in a setting of advanced age. Additionally, the specific cell population in SVF providing therapeutic benefit is unknown. We hypothesized that aging would alter the composition of cell populations present in SVF and its ability to promote angiogenesis following injury, a mechanism
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A Pilot Study Examining the Effects of Ischemic Conditioning on Walking Capacity and Lower Extremity Muscle Performance in Patients with Claudication J. Vasc. Res. (IF 1.7) Pub Date : 2022-09-06 Rory J. Loo, Max V. Wohlauer, Sergey S. Tarima, Elizabeth Weseman, Jennifer N. Nguyen, Neel A. Mansukhani, Matthew J. Durand
Introduction: This study investigated whether a novel therapy called ischemic conditioning (IC) improves walking capacity and lower extremity muscle performance in patients with peripheral vascular disease who experience intermittent claudication. Methods: Forty-three patients with claudication were enrolled and received either IC or IC Sham for 2 weeks in this randomized, controlled, double-blinded
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Connexin37 Regulates Cell Cycle in the Vasculature J. Vasc. Res. (IF 1.7) Pub Date : 2022-09-06 Jennifer S. Fang, Janis M. Burt
Control of vascular cell growth responses is critical for development and maintenance of a healthy vasculature. Connexins – the proteins comprising gap junction channels – are key regulators of cell growth in diseases such as cancer, but their involvement in controlling cell growth in the vasculature is less well appreciated. Connexin37 (Cx37) is one of four connexin isotypes expressed in the vessel
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A Pilot Study Examining the Effects of Ischemic Conditioning on Walking Capacity and Lower Extremity Muscle Performance in Patients with Claudication J. Vasc. Res. (IF 1.7) Pub Date : 2022-09-06
Introduction: This study investigated whether a novel therapy called ischemic conditioning (IC) improves walking capacity and lower extremity muscle performance in patients with peripheral vascular disease who experience intermittent claudication. Methods: Forty-three patients with claudication were enrolled and received either IC or IC Sham for 2 weeks in this randomized, controlled, double-blinded
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Connexin37 Regulates Cell Cycle in the Vasculature J. Vasc. Res. (IF 1.7) Pub Date : 2022-09-06
Control of vascular cell growth responses is critical for development and maintenance of a healthy vasculature. Connexins – the proteins comprising gap junction channels – are key regulators of cell growth in diseases such as cancer, but their involvement in controlling cell growth in the vasculature is less well appreciated. Connexin37 (Cx37) is one of four connexin isotypes expressed in the vessel
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Erratum J. Vasc. Res. (IF 1.7) Pub Date : 2022-08-31 B.E. Isakson, European Society for Microcirculation, U. Pohl, Ulrich Pohl, Marina Ziche, Jeremy D. Pearson, Gerald A. Meininger, Ed van Bavel, Jo G.R. De Mey, Ingrid Fleming, Akos Koller, J.G.R. de Mey, E. van Bavel, Eva Aralikatti, G.W. Schmid-Schönbein, Nicola J. Brown, Geraldine Clough, Jefferson C. Frisbee, Caryl Hill, Michael A. Hill, John D. Imig, Daniel Henrion, Ronald M. Lynch, Lydia Sorokin
J Vasc Res
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Perivascular Adipose Tissue Anticontractile Function Is Mediated by Both Endothelial and Neuronal Nitric Oxide Synthase Isoforms J. Vasc. Res. (IF 1.7) Pub Date : 2022-08-10 Sophie N. Saxton, Sarah B. Withers, Anthony M. Heagerty
Background: The mechanism of the perivascular adipose tissue (PVAT) anticontractile effect is well characterized in rodent visceral vascular beds; however, little is known about the mechanism of PVAT anticontractile function in subcutaneous vessels. In addition, we have previously shown that PVAT anticontractile function is nitric oxide synthase (NOS) dependent but have not investigated the roles of
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Perivascular Adipose Tissue Anticontractile Function Is Mediated by Both Endothelial and Neuronal Nitric Oxide Synthase Isoforms J. Vasc. Res. (IF 1.7) Pub Date : 2022-08-10
Background: The mechanism of the perivascular adipose tissue (PVAT) anticontractile effect is well characterized in rodent visceral vascular beds; however, little is known about the mechanism of PVAT anticontractile function in subcutaneous vessels. In addition, we have previously shown that PVAT anticontractile function is nitric oxide synthase (NOS) dependent but have not investigated the roles of
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Erratum J. Vasc. Res. (IF 1.7) Pub Date : 2022-07-22 B.E. Isakson, European Society for Microcirculation, U. Pohl, Ulrich Pohl, Marina Ziche, Jeremy D. Pearson, Gerald A. Meininger, Ed van Bavel, Jo G.R. De Mey, Ingrid Fleming, Akos Koller, J.G.R. de Mey, E. van Bavel, Eva Aralikatti, G.W. Schmid-Schönbein, Nicola J. Brown, Geraldine Clough, Jefferson C. Frisbee, Caryl Hill, Michael A. Hill, John D. Imig, Daniel Henrion, Ronald M. Lynch, Lydia Sorokin
J Vasc Res
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Smooth Muscle Cell Notch2 Is Not Required for Atherosclerotic Plaque Formation in ApoE Null Mice J. Vasc. Res. (IF 1.7) Pub Date : 2022-07-07 Jessica Davis-Knowlton, Jacqueline E. Turner, Anne Harrington, Lucy Liaw
Introduction: We previously identified Notch2 in smooth muscle cells (SMC) in human atherosclerosis and found that signaling via Notch2 suppressed human SMC proliferation. Thus, we tested whether loss of Notch2 in SMC would alter atherosclerotic plaque progression using a mouse model. Methods: Atherogenesis was examined at the brachiocephalic artery and aortic root in a vascular SMC null (inducible
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Smooth Muscle Cell Notch2 Is Not Required for Atherosclerotic Plaque Formation in ApoE Null Mice J. Vasc. Res. (IF 1.7) Pub Date : 2022-07-07
Introduction: We previously identified Notch2 in smooth muscle cells (SMC) in human atherosclerosis and found that signaling via Notch2 suppressed human SMC proliferation. Thus, we tested whether loss of Notch2 in SMC would alter atherosclerotic plaque progression using a mouse model. Methods: Atherogenesis was examined at the brachiocephalic artery and aortic root in a vascular SMC null (inducible
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Apolipoprotein A-I Inhibits Transendothelial Transport of Apolipoprotein B-Carrying Lipoproteins and Enhances Its Associated High-Density Lipoprotein Formation J. Vasc. Res. (IF 1.7) Pub Date : 2022-06-27 Zhongmao Guo, Ningya Zhang, Hong Yang
Caveola-located scavenger receptor type B class I (SR-BI) and activin receptor-like kinase-1 (ALK1) are involved in transendothelial transport of apolipoprotein B-carrying lipoproteins (apoB-LPs). Transport of apoB-LPs though mouse aortic endothelial cells (MAECs) is associated with apoE-carrying high-density lipoprotein (HDL)-like particle formation and apoAI induces raft-located proteins to shift
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Experimental Atherosclerosis Research on Large and Small Animal Models in Vascular Surgery J. Vasc. Res. (IF 1.7) Pub Date : 2022-06-27 Florian Simon, Axel Larena-Avellaneda, Sabine Wipper
Animal models have significantly advanced our understanding of the mechanisms of atherosclerosis formation and the evaluation of therapeutic options. The current focus of research is on preventive strategies and includes pharmacologic and biologic interventions directed primarily against smooth-muscle cell proliferation, endovascular devices for recanalization and/or drug delivery, and an integrated
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Apolipoprotein A-I Inhibits Transendothelial Transport of Apolipoprotein B-Carrying Lipoproteins and Enhances Its Associated High-Density Lipoprotein Formation J. Vasc. Res. (IF 1.7) Pub Date : 2022-06-27
Caveola-located scavenger receptor type B class I (SR-BI) and activin receptor-like kinase-1 (ALK1) are involved in transendothelial transport of apolipoprotein B-carrying lipoproteins (apoB-LPs). Transport of apoB-LPs though mouse aortic endothelial cells (MAECs) is associated with apoE-carrying high-density lipoprotein (HDL)-like particle formation and apoAI induces raft-located proteins to shift
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Experimental Atherosclerosis Research on Large and Small Animal Models in Vascular Surgery J. Vasc. Res. (IF 1.7) Pub Date : 2022-06-27
Animal models have significantly advanced our understanding of the mechanisms of atherosclerosis formation and the evaluation of therapeutic options. The current focus of research is on preventive strategies and includes pharmacologic and biologic interventions directed primarily against smooth-muscle cell proliferation, endovascular devices for recanalization and/or drug delivery, and an integrated
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Preservation of Adrenoceptor and Endothelin Receptor Mediated Vasoconstriction and of Endothelium-Dependent Relaxation after Cold Storage of Explanted Blood Vessels for ex vivo Analyses J. Vasc. Res. (IF 1.7) Pub Date : 2022-06-21 Markus Hoenicka, Marius Sabau, Andreas Liebold, Hans-Stefan Hofmann, Michael Ried
Introduction: Adrenoceptor and endothelin (ET) receptor-mediated vasoconstriction as well as endothelium-dependent vasodilation of human saphenous veins were compared before and after 20 h of cold storage. Methods: Contractile responses to potassium chloride (KCl), norepinephrine (NE), and ET-1 as well as vasodilator responses to acetylcholine (ACh) were evaluated. Results: Storage in HEPES-supplemented
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Perivascular Adipose Tissue Compensation for Endothelial Dysfunction in the Superior Mesenteric Artery of Female SHRSP.Z-Leprfa/IzmDmcr Rats J. Vasc. Res. (IF 1.7) Pub Date : 2022-04-29 Satomi Kagota, Risa Futokoro, Kana Maruyama-Fumoto, John J. McGuire, Kazumasa Shinozuka
Regulation of arterial tone by perivascular adipose tissue (PVAT) differs between sexes. In male SHRSP.Z-Leprfa/IzmDmcr rats (SHRSP.ZF), PVAT exerts a compensatory relaxation effect for the loss of endothelium-mediated vasorelaxation, which occurs during the early stages of metabolic syndrome. However, this effect deteriorates by 23 weeks of age. Here, therefore, we compared the effects of PVAT in
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A Novel ex vivo Method for Investigating Vascularization of Transplanted Islets J. Vasc. Res. (IF 1.7) Pub Date : 2022-04-22 Robert Dolan, Arinola O. Lampejo, Jorge Santini-González, Nicholas A. Hodges, Edward A. Phelps, Walter L. Murfee
Revascularization of transplanted pancreatic islets is critical for survival and treatment of type 1 diabetes. Questions concerning how islets influence local microvascular networks and how networks form connections with islets remain understudied and motivate the need for new models that mimic the complexity of real tissue. Recently, our laboratory established the rat mesentery culture model as a
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In vivo Evidence of Arterial Dynamic Properties Alteration in Atherosclerotic Rabbit J. Vasc. Res. (IF 1.7) Pub Date : 2022-04-19 Christine Vayssettes-Courchay, Christophe Ragonnet, Marc Isabelle, Marie-Pierre Bourguignon, Stefano Chimenti
Objectives: Atherosclerosis severely damages the arterial wall. The aim of this study was to assess in vivo, for the first time, arterial dynamic properties, reactivity, and stiffness in atherosclerotic (ATH) rabbits. Methods: The rabbits were fed with 0.3% cholesterol diet. Femoral artery (FA) or abdominal aorta (AA) diameter was recorded by echotracking, together with blood pressure. Arterial reactivity
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Establishment of Zebrafish Models for Diabetes Mellitus and Its Microvascular Complications J. Vasc. Res. (IF 1.7) Pub Date : 2022-04-04 Changsheng Chen, Dong Liu
Diabetes mellitus (DM) is a chronic metabolic disease known to cause several microvascular complications, including diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy. Hyperglycemia plays a key role in inducing diabetic microvascular complications. A cohort of diabetic animal models has been established to study diabetes-related vascular diseases. However, the zebrafish model offers
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Association between Arteriosclerosis and Uncontrolled Blood Pressure in Patients with Essential Hypertension: Cross-Sectional Observational Study Results of the BEST Study J. Vasc. Res. (IF 1.7) Pub Date : 2022-03-24 Huan Liu, Wei Huang, Jinbo Liu, Na Zhao, Hongyu Wang
Whether arteriosclerosis can influence the hypertension control remains incompletely understood. We hypothesized that higher arteriosclerosis may be associated with uncontrolled hypertension. Arteriosclerosis was assessed by carotid femoral artery pulse wave velocity (CF-PWV) and uncontrolled hypertension (systolic blood pressure [BP] ≥130 mm Hg or diastolic BP ≥80 mm Hg). The multivariable-adjusted
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Morphologic Mapping of the Sublingual Microcirculation in Healthy Volunteers J. Vasc. Res. (IF 1.7) Pub Date : 2022-03-21 Göksel Güven, Zühre Uz, Matthias P. Hilty, Burak Bilecenoğlu, Șakir Akin, Yasin Ince, Can Ince
Purpose: Monitoring the sublingual and oral microcirculation (SM-OM) using hand-held vital microscopes (HVMs) has provided valuable insight into the (patho)physiology of diseases. However, the microvascular anatomy in a healthy population has not been adequately described yet. Methods: Incident dark field-based HVM imaging was used to visualize the SM-OM. First, the SM was divided into four different
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Single-Cell RNA Sequencing Reveals Novel Genes Regulated by Hypoxia in J. Vasc. Res. (IF 1.7) Pub Date : 2022-03-16 Shelby Thomas, Sathiyanarayanan Manivannan, Vidu Garg, Brenda Lilly
Pulmonary arterial hypertension (PAH) is a chronic progressive disease with significant morbidity and mortality. The disease is characterized by vascular remodeling that includes increased muscularization of distal blood vessels and vessel stiffening associated with changes in extracellular matrix deposition. In humans, chronic hypoxia causes PAH, and hypoxia-induced rodent models of PAH have been
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Role of Blood Pressure Responses to Exercise and Vascular Insulin Sensitivity with Nocturnal Blood Pressure Dipping in Metabolic Syndrome J. Vasc. Res. (IF 1.7) Pub Date : 2022-03-10 Nathan R. Stewart, Emily M. Heiston, Stephanie L. Miller, Anna C. Ballantyne, Udeyvir S. Cheema, Andrea M. Spaeth, Peter Kokkinos, Steven K. Malin
Introduction: Nocturnal systolic blood pressure (SBP) dipping is independently related to cardiovascular disease risk, but it is unclear if vascular insulin sensitivity associates with SBP dipping in patients with metabolic syndrome (MetS). Methods: Eighteen adults with MetS (ATP III criteria 3.3 ± 0.6; 53.2 ± 6.5 years; body mass index 35.8 ± 4.5 kg/m2) were categorized as “dippers” (≥10% change in
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VEGF-Independent Angiogenic Factors: Beyond VEGF/VEGFR2 Signaling J. Vasc. Res. (IF 1.7) Pub Date : 2022-02-11 Ryoji Eguchi, Jun-ichi Kawabe, Ichiro Wakabayashi
Tumors induce angiogenesis to acquire oxygen and nutrition from their adjacent microenvironment. Tumor angiogenesis has been believed to be induced primarily by the secretion of vascular endothelial growth factor-A (VEGF-A) from various tumors. VEGF-A binds to VEGF receptor 2 (VEGFR2), resulting in subsequent activation of cellular substances regulating cell proliferation, survival, and angiogenesis
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CIDEC: A Potential Factor in Diabetic Vascular Inflammation J. Vasc. Res. (IF 1.7) Pub Date : 2022-02-04 Fang-Qiang Song, Hui-Min Zhou, Wei-Xuan Ma, Yu-Lin Li, Bo-Ang Hu, Yuan-Yuan Shang, Zhi-Hao Wang, Ming Zhong, Wei Zhang, Yun Ti
Cell death-inducing DFF45-like effector C (CIDEC) is involved in diet-induced adipose inflammation. Whether CIDEC plays a role in diabetic vascular inflammation remains unclear. A type 2 diabetic rat model was induced by high-fat diet and low-dose streptozotocin. We evaluated its characteristics by metabolic tests, Western blot analysis of CIDEC and C1q/tumor necrosis factor-related protein-3 (CTRP3)
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The Role of ADAMTS-4 in Atherosclerosis and Vessel Wall Abnormalities J. Vasc. Res. (IF 1.7) Pub Date : 2022-01-20 Rudjer Novak, Stela Hrkac, Grgur Salai, Josko Bilandzic, Luka Mitar, Lovorka Grgurevic
Extracellular matrix proteins are regulated by metzincin proteases, like the disintegrin metalloproteinases with thrombospondin motifs (ADAMTS) family members. This review focuses on the emerging role which ADAMTS-4 might play in vascular pathology, which has implications for atherosclerosis and vessel wall abnormalities, as well as for the resulting diseases, such as cardiovascular and cerebrovascular
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Erratum J. Vasc. Res. (IF 1.7) Pub Date : 2022-01-18 B.E. Isakson, European Society for Microcirculation, U. Pohl, Ulrich Pohl, Marina Ziche, Jeremy D. Pearson, Gerald A. Meininger, Ed van Bavel, Jo G.R. De Mey, Ingrid Fleming, Akos Koller, J.G.R. de Mey, E. van Bavel, Eva Aralikatti, G.W. Schmid-Schönbein, Nicola J. Brown, Geraldine Clough, Jefferson C. Frisbee, Caryl Hill, Michael A. Hill, John D. Imig, Daniel Henrion, Ronald M. Lynch, Lydia Sorokin
J Vasc Res
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Inflammation and Microcalcification: A Never-Ending Vicious Cycle in Atherosclerosis? J. Vasc. Res. (IF 1.7) Pub Date : 2022-01-17 Lynn Kawtharany, Laurence Bessueille, Hawraa Issa, Eva Hamade, Kazem Zibara, David Magne
Inflammatory cells and cytokines are known for long to worsen the development of atherosclerotic plaques in mice, and intense efforts are today devoted to develop anti-inflammatory therapeutic strategies to slow down plaque development. Increasing data indicate that plaque inflammation is intimately associated with microcalcifications, which exert harmful effects eventually culminating with plaque
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Vascular Smooth Muscle Cells Mechanosensitive Regulators and Vascular Remodeling J. Vasc. Res. (IF 1.7) Pub Date : 2021-12-22 Shangmin Liu, Zhanyi Lin
Blood vessels are subjected to mechanical loads of pressure and flow, inducing smooth muscle circumferential and endothelial shear stresses. The perception and response of vascular tissue and living cells to these stresses and the microenvironment they are exposed to are critical to their function and survival. These mechanical stimuli not only cause morphological changes in cells and vessel walls
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Recombinant Human Soluble Thrombomodulin Suppresses Arteritis in a Mouse Model of Kawasaki Disease J. Vasc. Res. (IF 1.7) Pub Date : 2021-12-20 Hironobu Nakayama, Hiroyasu Inada, Tatsuya Inukai, Kenta Kondo, Kazuyuki Hirai, Tomonari Tsutsumi, Yoshiyuki Adachi, Noriko Nagi-Miura, Naohito Ohno, Koji Suzuki
Introduction and Objective: Kawasaki disease (KD) is associated with diffuse and systemic vasculitis of unknown aetiology and primarily affects infants and children. Intravenous immunoglobulin (IVIG) treatment reduces the risk of developing coronary aneurysms, but some children have IVIG-resistant KD, which increases their risk of developing coronary artery injury. Here, we investigated the effect