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Perioperative Treatment with Rivaroxaban and Dabigatran on Changes of Coagulation and Platelet Activation Biomarkers following Left Atrial Appendage Closure Cardiovasc. Ther. (IF 3.1) Pub Date : 2024-3-12 Yao Yao, Yanli Li, Qinchun Jin, Xiaoye Li, Xiaochun Zhang, Qianzhou Lv
Insufficient data exist regarding the investigation of the impact of novel oral anticoagulants (NOACs) on coagulation activation biomarkers in the context of left atrial appendage closure (LAAC) and device-related thrombosis (DRT). The study was designed to investigate the changes and presence of coagulation activation biomarkers between different antithrombotic strategies following LAAC. A total of
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DUSP22 Ameliorates Endothelial-to-Mesenchymal Transition in HUVECs through Smad2/3 and MAPK Signaling Pathways Cardiovasc. Ther. (IF 3.1) Pub Date : 2024-3-8 Lu Chen, Hongyu Su, Zekai Tao, Cui Liang, Zhongzhao Liu, Yiming Dong, Peipei Zheng, Yuan Liu
Endothelial-to-mesenchymal transition (EndMT) is the process by which endothelial cells lose their endothelial properties and acquire mesenchymal characteristics. Dual-specific protein phosphatase 22 (DUSP22) inactivates various protein kinases and transcription factors by dephosphorylating serine/threonine residues: hence, it plays a key role in many diseases. The aim of this study was to explore
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Major Limitations of Cardiovascular Risk Scores Cardiovasc. Ther. (IF 3.1) Pub Date : 2024-2-28 Ibtissam Talha, Noureddine Elkhoudri, Abderraouf Hilali
Background. Epidemiological studies conducted in extensive population cohorts have led to the creation of numerous cardiovascular risk predictor models. However, these tools have certain limitations that restrict its applicability. The aim behind the following work is to summarize today’s best-known limitations of cardiovascular risk assessment models through presenting the critical analyses conducted
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Laminaria japonica Aresch-Derived Fucoidan Ameliorates Hyperlipidemia by Upregulating LXRs and Suppressing SREBPs Cardiovasc. Ther. (IF 3.1) Pub Date : 2024-2-12 Yan Zhang, Tian Liu, Ze-Jie Qu, Xue Wang, Wen-Gang Song, Shou-Dong Guo
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, and hyperlipidemia is one major inducing factor of CVD. It is worthy to note that fucoidans are reported to have hypolipidemic activity with species specificity; however, the underlying mechanisms of action are far from clarification. This study is aimed at investigating the plasma lipid-lowering mechanisms of the
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Assessment of Angiography-Based Renal Quantitative Flow Ratio Measurement in Patients with Atherosclerotic Renal Artery Stenosis Cardiovasc. Ther. (IF 3.1) Pub Date : 2024-1-9 Xiang Huang, Xiao-Lan Li, Heng Zhou, Xiao-Mei Li
Background. Quantitative flow ratio (QFR) is an angiography-based fractional flow reserve measurement without pressure wire or induction of hyperemia. A recent innovation that uses combined geometrical data and hemodynamic boundary conditions to measure QFR from a single angiographic view has shown the potential to measure QFR of the renal artery-renal QFR (rQFR). Objective. The aim of this pilot study
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Improving Health Outcomes in Coronary Artery Disease Patients with Short-Term Protocols of High-Intensity Interval Training and Moderate-Intensity Continuous Training: A Community-Based Randomized Controlled Trial Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-12-18 Catarina Gonçalves, Jorge Bravo, João Pais, Ana Abreu, Armando Raimundo
Studies have shown that the higher the aerobic capacity, the lower the risk of cardiovascular mortality and morbidity. In the case of cardiac patients, high-intensity interval training (HIIT) seems to be more effective than moderate-intensity continuous training (MICT) in improving aerobic capacity. The aim of this study was to investigate the effects of two community-based exercise programs using
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Valsartan Attenuated Homocysteine-Induced Impaired Autophagy and ER Stress in Human Umbilical Vein Endothelial Cells Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-12-13 Xinyan Wu, Ani Wang, Long Xu, Meng Li, Qingxian Zhai, Weidong Wang, Chunling Li, Lizi Jin
Hyperhomocysteinemia is a risk factor for various cardiovascular diseases. However, the mechanism underlying homocysteine- (Hcy-) induced vascular injury remains unclear. The purpose of the present study was to examine a potential mechanism by which Hcy induced injury in human umbilical vascular endothelial cells (HUVEC). The protein abundance of autophagy-related markers was markedly decreased after
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Ginkgolide B Blocks Vascular Remodeling after Vascular Injury via Regulating Tgfβ1/Smad Signaling Pathway Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-12-13 Quan Wang, Shuai Ni, Li Ling, Siqi Wang, Hanbin Xie, Zhanhong Ren
Coronary artery disease (CAD) is the most prevalent cardiovascular disease worldwide, resulting in myocardial infarction (MI) and even sudden death. Following percutaneous coronary intervention (PCI), restenosis caused by vascular remodeling is always formed at the stent implantation site. Here, we show that Ginkgolide B (GB), a naturally occurring terpene lactone, effectively suppresses vascular remodeling
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Relationship between β1-AA and AT1-AA and Cardiac Function in Patients with Hypertension Complicated with Left Ventricular Diastolic Function Limitation Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-12-13 Liang Wang, Xue-Bai Lv, Yu-Ting Yuan, Ning Wang, Hong-Ying Yao, Wen-Chao Zhang, Peng-Fei Yin, Xiao-Hui Liu
Objective. To investigate the association between β1 adrenergic receptor autoantibodies (β1-AA) and angiotensin II type-1 receptor autoantibodies (AT1-AA) and cardiac function in patients with hypertension complicated with left ventricular diastolic function limitation. Methods. A total of 120 patients with essential hypertension who were not taking drug treatment and were hospitalised in the Department
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Frequencies of VKORC1-1639G>A and rs397509427 in Patients on Warfarin and Healthy Syrian Subjects Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-11-23 Yara Altawil, Lama A. Youssef
Background. Vitamin K epoxide reductase complex subunit 1 (VKORC1) gene encodes a key enzyme with multiple cellular activities, namely, the reduction of vitamin K to its active form. VKORC1-1639G>A (rs9923231) is a common single nucleotide polymorphism with a crucial impact on warfarin dosing and possibly other physiological functions. This study aimed at investigating the frequencies of VKORC1-1639G>A
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Effect of Thrombolysis on Circulating Microparticles in Patients with ST-Segment Elevation Myocardial Infarction Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-11-18 Zhe Li, Wei Zhang, Qun-Rang Wang, Yu-juan Yang, Xin-Hong Liu, Gong Cheng, Feng-Jun Chang
Objective. We demonstrated that circulating microparticles (MPs) are increased in patients with coronary heart disease (both chronic coronary syndrome (CCS) and acute coronary syndrome). Whether thrombolysis affects MPs in patients with ST-segment elevation myocardial infarction (STEMI) with or without percutaneous coronary intervention (PCI) is unknown. Methods. This study was divided into three groups:
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Role of K+ and Ca2+ Channels in the Vasodilator Effects of Plectranthus barbatus (Brazilian Boldo) in Hypertensive Rats Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-11-17 Jeniffer Cristóvão Moser, Rita de Cássia Vilhena da Silva, Philipe Costa, Luisa Mota da Silva, Nadla Soares Cassemiro, Arquimedes Gasparotto Junior, Denise Brentan Silva, Priscila de Souza
Plectranthus barbatus, popularly known as Brazilian boldo, is used in Brazilian folk medicine to treat cardiovascular disorders including hypertension. This study investigated the chemical profile by UFLC-DAD-MS and the relaxant effect by using an isolated organ bath of the hydroethanolic extract of P. barbatus (HEPB) leaves on the aorta of spontaneously hypertensive rats (SHR). A total of nineteen
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Circulating FABP-4 Levels in Patients with Atherosclerosis or Coronary Artery Disease: A Comprehensive Systematic Review and Meta-Analysis Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-11-17 Narges Jalilian, Reza Pakzad, Mahdi Shahbazi, Seyyed-Reza Edrisi, Karimeh Haghani, Mohsen Jalilian, Salar Bakhtiyari
Background. Cardiovascular diseases (CDs), notably coronary artery disease (CAD) due to atherosclerosis, impose substantial global health and economic burdens. Fatty acid-binding proteins (FABPs), including FABP-4, have been recently linked to CDs. This study conducted a systematic review and meta-analysis to examine FABP-4 levels in CAD and atherosclerosis patients, exploring their potential links
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Identifying Factors for Low-Risk Participation in Alternative Cardiac Rehabilitation Models for Patients with Coronary Heart Disease Using MI’S SCOREPAD Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-9-8 Eric J. Brandt, Joshua Garfein, Chih-Wen Pai, Joseph Bryant, Eva Kline-Rogers, Samantha Fink, Melvyn Rubenfire
Introduction. Although a recent joint society scientific statement (the American Association of Cardiovascular Pulmonary Rehabilitation, the American Heart Association, and the American College of Cardiology) suggests home-based cardiac rehab (CR) is appropriate for low- and moderate-risk patients, there are no paradigms to define such individuals with coronary heart disease. Methods. We reviewed a
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Elevated Serum Total Bilirubin Might Indicate Poor Coronary Conditions for Unstable Angina Pectoris Patients beyond as a Cardiovascular Protector Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-9-5 Qi Liang, Yongjian Zhang, Jin Liang
Backgrounds. Serum total bilirubin (STB) is recently more regarded as an antioxidant with vascular protective effects. However, we noticed that elevated STB appeared in unstable angina pectoris (UAP) patients with diffused coronary lesions. We aimed to explore STB’s roles in UAP patients, which have not been reported by articles. Methods and Results. 1120 UAP patients were retrospectively screened
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Left Bundle Branch Area Pacing versus Right Ventricular Pacing in Patients with Atrioventricular Block: An Observational Cohort Study Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-8-21 Zhongxiu Chen, Yuanning Xu, Lingyun Jiang, Ran Zhang, Hongsen Zhao, Ran Liu, Lei Zhang, Yajiao Li, Xingbin Liu
Objective. We aim to conduct a comparison of the safety and effectiveness performance between left bundle branch area pacing (LBBAP) and right ventricular pacing (RVP) regimens for patients with atrioventricular block (AVB). Methods. This observational cohort study included patients who underwent pacemaker implantations with LBBAP or RVP for AVB indications from the 1st of January 2018 to the 18th
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Comparison of Different Chronic Maintenance Antithrombotic Strategies in Patients with Coronary Artery Disease: A Systematic Review and Network Meta-Analysis Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-8-17 Junyan Zhang, Zhongxiu Chen, Yujia Cai, Chen Li, Yong He
Background. Optimal antithrombotic therapy during the chronic maintenance period in patients with coronary artery disease (CAD) is unknown. We compared five kinds of mainstream chronic maintenance antithrombotic strategies at least one year after the acute phase: aspirin alone, clopidogrel alone, ticagrelor alone, continued dual antiplatelet therapy (DAPT) for a period of time, and maintenance with
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Drug-Coated Balloon-Only Strategy for De Novo Coronary Artery Disease: A Meta-analysis of Randomized Clinical Trials Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-8-8 Wenyi Zhang, Mingduo Zhang, Jinfan Tian, Min Zhang, Yuan Zhou, Xiantao Song
Backgrounds. Many clinical trials have demonstrated the value of drug-coated balloons (DCB) for in-stent restenosis. However, their role in de novo lesions is not well documented. The aim of this study is to evaluate the safety and efficacy of the DCB-only strategy compared to other percutaneous coronary intervention strategies for de novo coronary lesions. Methods. The PubMed, Embase, Web of Science
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Heart Failure with Preserved Left Ventricular Ejection Fraction: A Complex Conundrum Simply Not Limited to Diastolic Dysfunction Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-7-18 Angel Lopez-Candales, Talal Asif, Khalid Sawalha, Nicholas B. Norgard
Over the last two decades, the changing paradigm of heart failure with preserved ejection fraction (HFpEF) has transformed our understanding not only of the pathophysiology of this clinical entity but also the diagnostic and therapeutic approaches aimed at treating this complex patient population. No longer HFpEF should be seen as simply left ventricular diastolic dysfunction but as a group of that
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Water-Based Exercises on Peak Oxygen Consumption, Exercise Time, and Muscle Strength in Patients with Coronary Artery Disease: A Systematic Review with Meta-Analysis Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-6-26 Alana Lalucha Andrade Guimarães, Mansueto Gomes-Neto, Lino Sérgio Rocha Conceição, Micheli Bernardone Saquetto, Caroline Oliveira Gois, Vitor Oliveira Carvalho
Background. There is a growing use of water-based exercises in cardiac rehabilitation programs. However, there is little data concerning the effects of water-based exercise on the exercise capacity of coronary artery disease (CAD) patients. Objective. To perform a systematic review to investigate the effects of water-based exercise on peak oxygen consumption, exercise time, and muscle strength in patients
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The Regulation Network of Glycerolipid Metabolism as Coregulators of Immunotherapy-Related Myocarditis Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-6-21 Xiguang Yang, Xiaopeng Duan, Zhenglin Xia, Rui Huang, Ke He, Guoan Xiang
Background. To date, immunotherapy for patients with malignant tumors has shown a significant association with myocarditis. However, the mechanism of metabolic reprogramming changes for immunotherapy-related cardiotoxicity is still not well understood. Methods. The CD45+ single-cell RNA sequencing (scRNA-seq) of the Pdcd1-/-Ctla4+/- and wild-type mouse heart in GSE213486 was downloaded to demonstrate
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Statin Eligibility according to 2013 ACC/AHA and USPSTF Guidelines among Jordanian Patients with Acute Myocardial Infarction: The Impact of Gender Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-6-5 Rashid Ibdah, Ahmad Alrawashdeh, Sukaina Rawashdeh, Nebras Y. Melhem, Ayman J. Hammoudeh, Mohamad I. Jarrah
The objectives of this study were to evaluate statin eligibility among Middle Eastern patients admitted with acute myocardial infarction (AMI) who had no prior use of statin therapy, according to 2013 ACC/AHA and 2016 USPSTF guidelines, and to compare statin eligibility between men and women. This was a retrospective multicenter observational study of all adult patients admitted to five tertiary care
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E-Selectin/AAV Gene Therapy Promotes Myogenesis and Skeletal Muscle Recovery in a Mouse Hindlimb Ischemia Model Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-5-19 Antoine J. Ribieras, Yulexi Y. Ortiz, Yan Li, Nga T. Le, Carlos T. Huerta, Francesca A. Voza, Hongwei Shao, Roberto I. Vazquez-Padron, Zhao-Jun Liu, Omaida C. Velazquez
The response to ischemia in peripheral artery disease (PAD) depends on compensatory neovascularization and coordination of tissue regeneration. Identifying novel mechanisms regulating these processes is critical to the development of nonsurgical treatments for PAD. E-selectin is an adhesion molecule that mediates cell recruitment during neovascularization. Therapeutic priming of ischemic limb tissues
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Analysis of the Efficacy and Safety of Coronary Catheterization through Distal Transradial Access: A Single-Center Data Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-5-16 Huanhuan Wang, Dan Liu, Jidong Guo, Nuerbahati Heisha, Lei Wang, Qiang Zhang, Yihui Han, Xiping Wang, Bo Zhang, Jinqing Yuan, Lijian Gao
Background and Aims. The distal transradial access (dTRA) is a new puncture site for coronary catheterization. We sought to evaluate the feasibility, safety, and complication rates of using the dTRA for cardiac catheterization in Chinese patients. Methods. A total of 263 consecutive patients who underwent catheterization through the dTRA were enrolled. The primary endpoint of the study was the rate
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Pulegone Prevents Hypertension through Activation of Muscarinic Receptors and Cyclooxygenase Pathway in L-NAME-Induced Hypertensive Rats Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-5-11 Muryam Abdul Razzaq, Waqas Younis, Muhammad Nasir Hayat Malik, Tariq G. Alsahli, undefined Alamgeer, Shah Jahan, Roma Ehsan, Arquimedes Gasparotto Junior, Asifa Bashir
The current study was designed to determine pulegone’s antihypertensive and vasoprotective activity in L-NAME-induced hypertensive rats. Firstly, the hypotensive dose-response relationship of pulegone was evaluated in normotensive anesthetized rats using the invasive method. Secondly, the mechanism involved in hypotensive activity was determined in the presence of pharmacological drugs such as atropine/muscarinic
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miR-135a Regulates Atrial Fibrillation by Targeting Smad3 Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-5-5 Xueting Fan, Kai Feng, Yonghui Liu, Leixi Yang, Yizhuo Zhao, Liping Tian, Yiqun Tang, Xiaozhi Wang
Background. Atrial fibrillation (AF) is the most common arrhythmia in clinical. Atrial fibrosis is a hallmark feature of atrial structural remodeling in AF, which is regulated by the TGF-β1/Smad3 pathway. Recent studies have implicated that miRNAs are involved in the process of AF. However, the regulatory mechanisms of miRNAs remain largely unknown. This study is aimed at investigating the function
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Cardioprotection of mAb2G4/ODN/lip on Myocardial Ischemia-Reperfusion Injury via Inhibiting the NF-κB Signaling Pathway Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-4-27 Zujin Xu, Zhuoran Wei, Yali Zhu, Guoqing Jing, Liufang Chen, Jia Zhan, Yun Wu
Substantial evidence suggests that the interventions of NF-κB would likely effectively prevent inflammatory response and reduce myocardial damage in the ischemic myocardium. And the NF-кB decoy ODN is a specific inhibitor that suppresses the expression of NF-κB. Herein, we revealed the effect and possible mechanism of mAb2G4/ODN/lip on myocardial ischemia-reperfusion injury (MI/RI). As shown in the
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Effect of Statins on Major Adverse Cardiovascular Events in Patients with Coronary Artery Spasm: A Meta-Analysis of the Asia Region Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-4-27 Tian-Jun Zhao, Duan Luo, Xi Jiang, Feng Tang, Hui Jiang
Background. Whether statins can reduce major cardiovascular adverse events (MACE) in patients with coronary artery spasm (CAS) is controversial. And most of the relevant research to date has been conducted in Asia. Methods. We systematically searched electronic databases for studies on the effect of statins on MACE in patients with CAS in Asia and published up to September 2022. We included data on
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Efficacy of Acupuncture in the Treatment of Essential Hypertension: An Overview of Systematic Reviews and Meta-Analyses Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-4-18 Maoxia Fan, Guohua Dai, Runmin Li, Xiaoqi Wu
Background. Acupuncture is widely used in the clinical treatment of essential hypertension (EH). This overview is aimed at summarizing current systematic reviews of acupuncture for EH and assessing the methodological bias and quality of evidence. Methods. Two researchers searched and extracted 7 databases for systematic reviews (SRs)/meta-analyses (MAs) and independently assessed the methodological
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KCa3.1 Promotes Proinflammatory Exosome Secretion by Activating AKT/Rab27a in Atrial Myocytes during Rapid Pacing Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-3-30 Dishiwen Liu, Huiyu Chen, Yuntao Fu, Yajun Yao, Shanqing He, Youcheng Wang, Zhen Cao, Xuewen Wang, Mei Yang, Qingyan Zhao
Purpose. The aim of this study was to investigate the role of the medium-conductance calcium-activated potassium channel (KCNN4, KCa3.1) in the secretion of proinflammatory exosomes by atrial myocytes. Methods. Eighteen beagles were randomly divided into the sham group (), pacing group (), and pacing+TRAM-34 group (). Electrophysiological data, such as the effective refractory period, atrial fibrillation
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Mass Cytometry Reveals the Imbalanced Immune State in the Peripheral Blood of Patients with Essential Hypertension Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-2-27 Rui Yang, Yuhong He, Honggang Zhang, Qiuju Zhang, Bingwei Li, Changming Xiong, Yubao Zou, Bingyang Liu
Mounting evidence has confirmed that essential hypertension (EH) is closely related to low-grade inflammation, but there is still a lack of in-depth understanding of the state of immune cells in the circulating blood of patients with EH. We analyzed whether hypertensive peripheral blood immune cell balance was destroyed. The peripheral blood mononuclear cells (PBMCs) of all subjects were analyzed using
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Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-2-22 Runmei Zou, Shuo Wang, Hong Cai, Yuwen Wang, Cheng Wang
Background. Doxorubicin-induced cardiotoxicity has been closely concerned in clinical practice. Rev-erbα is a transcriptional repressor that emerges as a drug target for heart diseases recently. This study is aimed at investigating the role and mechanism of Rev-erbα in doxorubicin-induced cardiotoxicity. Methods. H9c2 cells were treated with 1.5 μM doxorubicin, and C57BL/6 mice were treated with a
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Bardoxolone Methyl Ameliorates Myocardial Ischemia/Reperfusion Injury by Activating the Nrf2/HO-1 Signaling Pathway Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-2-22 Anwu Huang, Zhaolin Wang, Hua Tang, Zhuyin Jia, Xiaojun Ji, Xuehua Yang, Wenbing Jiang
Background. Myocardial ischemia/reperfusion (I/R) injury is a severe heart problem resulting from restoring coronary blood flow to the myocardium after ischemia. This study is aimed at ascertaining the therapeutic efficiency and action mechanism of bardoxolone methyl (BARD) in myocardial I/R injury. Methods. In male rats, myocardial ischemia was performed for 0.5 h, and then, reperfusion lasted for
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DT-010 Exerts Cardioprotective Effects by Regulating the Crosstalk between the AMPK/PGC-1α Pathway and ERp57 Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-2-10 Xiaojing Zhang, Ximin Wu, Huihui Hu, Xiaoping Liu, Zhanfang Kang, Xin Deng
The AMP-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) pathway performs a crucial role in energy metabolism and mitochondrial network. Our previous study found that DT-010, a novel danshensu (DSS) and tetramethylpyrazine (TMP) conjugate, had significant cardioprotective properties in vitro and in vivo. We also reported that ERp57 served as a major
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Identification of Potential Biomarkers for Coronary Artery Disease Based on Cuproptosis Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-1-25 Bohong Zhang, Mingliang He
Identifying peripheral biomarkers is an important noninvasive diagnosis method for coronary artery disease (CAD) which has aroused the strong interest of researchers. Cuproptosis, a newly reported kind of programmed cell death, is closely related to mitochondrial respiration, adenosine triphosphate (ATP) production, and the TCA cycle. Currently, no studies have been published about the effects of cuproptosis-related
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Social App to Improve Warfarin Therapy in Post-MHVR Chinese Patients: A Randomized Controlled Trial Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-1-14 Litao Zhang, Sha Li, Zishuo Li, Dan Yu, Haiyan Wu, Bing Hua, Li Xie, Xia Yuan, Yun Li, Zhenlu Zhang, Yanli Long
Background. Poor anticoagulation quality was a major problem among warfarin-treated patients, which called for innovative and effective methods to improve it. Objective. To investigate whether social app could be used to reduce warfarin-associated adverse events among post-MHVR Chinese patients. Method. 735 warfarin-treated patients (, 59.9% female) were enrolled and randomized to a social app care
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The Effect of Clinically Indicated Liraglutide on Pericoronary Adipose Tissue in Type 2 Diabetic Patients Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-1-14 Irmelin I. A. Biesenbach, Laurits J. Heinsen, Katrine S. Overgaard, Thomas R. Andersen, Søren Auscher, Kenneth Egstrup
Vascular inflammation can be detected in the pericoronary adipose tissue (PCAT) by coronary computed tomography angiography (CCTA) attenuation. Treatment with liraglutide is associated with anti-inflammatory effects and reduces cardiovascular risk in diabetic patients. This study is aimed at examining the effect of clinically indicated liraglutide on PCAT attenuation. Asymptomatic patients with type
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Effect of TRIB1 Variant on Lipid Profile and Coronary Artery Disease: A Systematic Review and Meta-Analysis Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-1-9 Baozhu Wei, Yang Liu, Hang Li, Yuanyuan Peng, Zhi Luo
Background. Emerging evidence indicates tribbles homolog 1 (Trib1) protein may be involved in lipid metabolism regulation and coronary artery disease (CAD) pathogenesis. However, whether TRIB1 gene variants affect lipid levels and CAD remains elusive, this study is aimed at clarifying the effect of TRIB1 variants on lipid profile and CAD. Methods. By searching PubMed and Cochrane databases for studies
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An Updated Meta-Analysis for Safety Evaluation of Alirocumab and Evolocumab as PCSK9 Inhibitors Cardiovasc. Ther. (IF 3.1) Pub Date : 2023-1-4 Hye Duck Choi, Ji Hae Kim
Background. Alirocumab and evolocumab, as protein convertase subtilisin kexin type 9 (PCSK9) inhibitors, have been reported to reduce cardiovascular risk. This meta-analysis is aimed at updating the safety data of PCSK9 inhibitors. Methods. We assessed the relative risk for all treatment-related adverse events, serious adverse events, diabetes-related adverse events, and neurocognitive and neurologic
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Beta-Blockers for Primary Prevention of Anthracycline-Induced Cardiac Toxicity: An Updated Meta-Analysis of Randomized Clinical Trials Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-12-29 Armin Attar, Arman Karimi Behnagh, Mehrasa Hosseini, Foad Amanollahi, Paria Shafiekhani, Ali Kabir
Aim. Cardiotoxicity is a well-recognized complication of chemotherapy with Anthracyclines. However, results from trials evaluating beta-blockers for prevention are controversial. Therefore, we performed a meta-analysis to find whether prophylactic administration of beta-blockers can help prevent Anthracyclines-induced cardiotoxicity. Methods. We assessed randomized trials and observational studies
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Predicting Risk Factors of Acute Kidney Injury in the First 7 Days after Admission: Analysis of a Group of Critically Ill Patients Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-12-21 Kexin Wen, Yongqing Huang, Qi Guo, Tao Wu, Juanzhang Liu, Yuping Zheng, Shuxian Zhou, Dengfeng Geng
Background. Acute kidney injury (AKI) is a common complication in critically ill patients. Some predictive models have been reported, but the conclusions are controversial. The aim of this study was the formation of nomograms to predict risk factors for AKI in critically ill patients within the first 7 days after admission to the intensive care unit (ICU). Methods. Data were extracted from the Medical
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The Effect of the Tongyang Huoxue Recipe (TYHX) on the Ito/IKur in Ischemia/Reperfusion Sinoatrial Node Cells Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-12-20 Yanli Wang, Qiaomin Wu, Jinfeng Liu, Ruxiu Liu
Background. The transient outward potassium current (Ito) and the ultrarapid delayed rectifier potassium current (IKur) are major potassium currents involved in the repolarization process of sinoatrial node cells (SNCs). Methods and Results. The SNCs of neonatal rats were divided into control, ischemia/reperfusion (I/R), I/R+blank serum, and Tongyang Huoxue recipe (TYHX) serum groups. Ito and IKur
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Vericiguat: A New Hope for Heart Failure Patients Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-12-17 Raquel Chiles, Rami A. Al-Horani
Heart failure with reduced ejection fraction (HFrEF) is the inability of the heart to adequately contract or eject blood. This heart is unable to produce adequate cardiac output to perfuse vital tissues. At a fundamental level, it is known that the cardioprotective pathway of nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate is impaired in heart failure patients. Vericiguat is a
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Long Noncoding RNA SNHG4 Attenuates the Injury of Myocardial Infarction via Regulating miR-148b-3p/DUSP1 Axis Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-12-5 Sheng Wang, Zhaoyun Cheng, Xianjie Chen, Guoqing Lu, Xiliang Zhu, Gaojun Xu
Objective. Long noncoding RNAs (lncRNAs), including some members of small nucleolar RNA host gene (SNHG), are important regulators in myocardial injury, while the role of SNHG4 in myocardial infarction (MI) is rarely known. This study is aimed at exploring the regulatory role and mechanisms of SNHG4 on MI. Methods. Cellular and rat models of MI were established. The expression of relating genes was
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lncRNA NEAT1 Downregulation Ameliorates the Myocardial Infarction of Mice by Regulating the miR-582-5p/F2RL2 Axis Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-12-3 Zhenhua Wu, Yunpeng Bai, Yujuan Qi, Chao Chang, Yan Jiao, Yaobang Bai, Zhigang Guo
Background. This study is aimed at effectively investigating the role of coagulation factor II thrombin receptor like 2 (F2RL2) in myocardial infarction (MI) as well as the upstream regulatory miRNA and lncRNA. Methods. Regulatory genes of F2RL2 were analyzed using StarBase and verified by dual-luciferase reporter assay. The MI mouse model was established. The left ventricular ejection fraction (EF)
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A Study on Weight Loss Cause as per the Side Effect of Liraglutide Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-12-2 Jin Yu, Jeongmin Lee, Seung-Hwan Lee, Jae-Hyung Cho, Hun-Sung Kim
Purpose. Liraglutide is known to have much lower weight loss effects in real clinical fields than in randomized clinical trials because of its side effects (SE) and discomfort associated with injections. This study is aimed at determining whether the side effects of liraglutide affect weight reduction and its maintenance in real-world practice. Methods. Endocrinologists conducted a retrospective chart
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Safety and Efficacy of Bivalirudin versus Unfractionated Heparin Monotherapy in Patients with CAD and DM Undergoing PCI: A Retrospective Observational Study Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-11-30 Jing Li, Sanbao Chen, Sicong Ma, Mingque Yang, Zizhao Qi, Kun Na, Miaohan Qiu, Yi Li, Yaling Han
Introduction. Optimal anticoagulants for patients with diabetes mellitus (DM) undergoing percutaneous coronary intervention (PCI) are unclear. This retrospective observational study is aimed at evaluating efficacy and safety of bivalirudin versus unfractionated heparin (UFH) monotherapy in patients with DM undergoing PCI. Methods. A total of 3890 diabetic patients receiving PCI in the General Hospital
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Noncoding RNA in the Regulation of Acute Aortic Dissection: From Profile to Mechanism Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-11-18 Ruibin Wei, Yingqing Feng
Aortic dissection is a life-threatening condition caused by a tear in the intimal layer of the aorta or bleeding within the aortic wall, resulting in the separation of the layers of the aortic wall. As Nienaber reported, aortic dissection is most common in people 65–75 years old and has an incidence of 35 cases per 100,000 people per year in this population. Many pathogenic factors are involved in
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Knockdown of lncRNA XIST Ameliorates IL-1β-Induced Apoptosis of HUVECs and Change of Tissue Factor Level via miR-103a-3p/HMGB1 Axis in Deep Venous Thrombosis by Regulating the ROS/NF-κB Signaling Pathway Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-11-18 Guangxin Cao, Hua Zhou, Dong Wang, Lei Xu
Background. The effect of lncRNA X inactive-specific transcript (XIST) inducing cardiovascular diseases on deep vein thrombosis (DVT) and its mechanism has not been reported. In this study, we uncovered the mystery that lncRNA XIST causes DVT with HUVEC dysfunction. Method. The expression levels of lncRNA XIST and miR-103a-3p were detected by qRT-PCR, and HMGB1 expression was determined by qRT-PCR
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Inflammatory Response and Immune Regulation in Brain-Heart Interaction after Stroke Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-11-16 Lihua Zou, Ruquan Han
Cerebrocardiac syndrome (CCS) is one of the secondary myocardial injuries after stroke. Cerebrocardiac syndrome may result in a poor prognosis with high mortality. Understanding the mechanism of the brain-heart interaction may be crucial for clinical treatment of pathological changes in CCS. Accumulating evidence suggests that the inflammatory response is involved in the brain-heart interaction after
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Potential Roles of Glucagon-Like Peptide 1 Receptor Agonists (GLP-1 RAs) in Nondiabetic Populations Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-11-16 Dan Xu, Ankith Nair, Charlie Sigston, Chau Ho, Jia Li, Daya Yang, Xinxue Liao, Wei Chen, Ming Kuang, Yanbing Li, Christopher Reid, Haipeng Xiao
Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) have been observed in several large cardiovascular outcome trials to significantly reduce the incidence of major cardiovascular event (MACE) with type 2 diabetic patients. The clinical trials of GLP-1 RAs, including lixisenatide, exenatide, liraglutide, semaglutide, albiglutide, and dulaglutide, are associated with a significantly 14% lower risk
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HSPB1 Regulates Autophagy and Apoptosis in Vascular Smooth Muscle Cells in Arteriosclerosis Obliterans Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-11-14 Keqin Chen, Changmiao Hou, Lei Xu, Hanwu Peng, Chaogui He, Jing Liu, Guoqing Wang, Shaoshuai Huang, Xiehong Liu
Objective. Small heat shock protein-1 (HSPB1) is a small heat shock protein that participates in many cellular processes and alleviates stress-induced cell injury. Autophagy protects cells from many types of stress and plays a key role in preventing stress in arteriosclerosis obliterans (ASO). However, the roles of HSPB1 in autophagy and apoptosis in the context of ASO pathogenesis remain unclear.
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Positive Association of Plasma Trimethylamine-N-Oxide and Atherosclerosis in Patient with Acute Coronary Syndrome Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-11-3 Wanwen Kong, Junyi Ma, Ying Lin, Weiyu Chen
Aim. Atherosclerosis is the major cause of acute coronary syndrome (ACS) which is a significant contributor to both morbidity and mortality in the world. The microbiome-derived metabolite trimethylamine-N-oxide (TMAO) has aroused great interest and controversy as a risk factor of atherosclerosis. Therefore, in this study, we aimed at investigating whether plasma TMAO can be a risk factor of atherosclerosis
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A Clinical Nomogram Based on the Triglyceride-Glucose Index to Predict Contrast-Induced Acute Kidney Injury after Percutaneous Intervention in Patients with Acute Coronary Syndrome with Diabetes Mellitus Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-10-27 Yue Hu, Xiaotong Wang, Shengjue Xiao, Na Sun, Chunyan Huan, Huimin Wu, Minjia Guo, Tao Xu, Defeng Pan
The aim of the study was to investigate the factors influencing contrast-induced acute kidney injury (CI-AKI) after percutaneous intervention (PCI) in patients with acute coronary syndrome (ACS) with diabetes mellitus (DM). A total of 1073 patients with ACS combined with DM who underwent PCI at the Affiliated Hospital of Xuzhou Medical University were included in this study. We divided the patients
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Updates on Pharmacologic Management of Microvascular Angina Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-10-25 Mosayeb Soleymani, Farzad Masoudkabir, Mahsima Shabani, Ali Vasheghani-Farahani, Amir Hossein Behnoush, Amirmohammad Khalaji
Microvascular angina (MVA), historically called cardiac syndrome X, refers to angina with nonobstructive coronary artery disease. This female-predominant cardiovascular disorder adds considerable health-related costs due to repeated diagnostic angiography and frequent hospital admissions. Despite the high prevalence of this diagnosis in patients undergoing coronary angiography, it is still a therapeutic
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Comparison between Cardiac CTA and Echocardiography for Assessment of Ventricular Septal Rupture Diameter and Its Effect on Transcatheter Closure Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-10-17 Tongfeng Chen, Yuhao Liu, Jing Zhang, Zirui Sun, Jiangtao Cheng, Yu Han, Chuanyu Gao
Objective. This study is aimed at comparing cardiac computed tomographic angiography (CTA) with echocardiography in the assessment of ventricular septal perforation diameter. Methods. A total of 44 ventricular septal rupture (VSR) patients undertaking transcatheter occlusion were included and randomly divided into the CTA group and echocardiography group with a 1 : 1 ratio. Clinical data, operation-related
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Biological Properties and Clinical Significance of Lipoprotein-Associated Phospholipase A2 in Ischemic Stroke Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-10-14 Shuang Zhang, Shuchun Huang, Dingju Hu, Fenglong Jiang, Yanli Lv, Guoqi Liu
Ischemic stroke, which occurs following blockage of the blood supply to the brain, is a leading cause of death worldwide. Its main cause is atherosclerosis, a disease of the arteries characterized by the deposition of plaques of fatty material on the inner artery walls. Multiple proteins involved in the inflammation response have been identified as diagnosing biomarkers of ischemic stroke. One of these
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Colchicine Does Not Reduce Abdominal Aortic Aneurysm Growth in a Mouse Model Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-9-30 James Phie, Shivshankar Thanigaimani, Pacific Huynh, Raghuveeran Anbalagan, Corey S. Moran, Robert Kinobe, Joseph V. Moxon, Matt A. Field, Smriti M. Krishna, Jonathan Golledge
Background and Aims. The nacht domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome is upregulated in human abdominal aortic aneurysm (AAA), but its pathogenic role is unclear. The aims of this study were firstly to examine whether the inflammasome was upregulated in a mouse model of AAA and secondly to test whether the inflammasome inhibitor colchicine limited AAA
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Association of Choline Intake with Blood Pressure and Effects of Its Microbiota-Dependent Metabolite Trimethylamine-N-Oxide on Hypertension Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-08-25 Guo-dong He, Xiao-cong Liu, An-shang Lu, Ying-qing Feng
Background. The association of total choline (TC) intake and its metabolite trimethylamine-N-oxide (TMAO) with hypertension and blood pressure (BP) has not been elucidated. Methods. For the population study, the association of TC intake with hypertension, as well as blood pressure, was determined through logistic along with multiple linear regression analysis from the National Health and Nutrition
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Silencing RNA for MMPs May Be Utilized for Cardioprotection Cardiovasc. Ther. (IF 3.1) Pub Date : 2022-08-24 Marta Banaszkiewicz, Anna Krzywonos-Zawadzka, Agnieszka Olejnik, Agnieszka Noszczyk-Nowak, Iwona Bil-Lula
Ischemia/reperfusion (I/R) injury is accompanied by an increase of matrix metalloproteinase 2 (MMP-2) activity, which degrades heart contractile proteins. The aim of the study was to investigate the effect of MMP-2 small interfering RNA (MMP-2 siRNA) administration on I/R heart. Isolated rat hearts perfused by the Langendorff method were subjected to I/R in the presence or absence of MMP-2 siRNA. The