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Simulated patients to demonstrate common stroke syndromes: accurate and convincing. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-11-23 Cora Koch,Simone Meier,Cornelia Fischer,Jochen Brich
Introduction Stroke detection in the preclinical setting is challenging, resulting in more than 1/3 of missed strokes by EMS personnel. Recently, prehospital identification of anterior large vessel occlusion (LVO) stroke has come into focus. Cortical signs have a high predictive value for the presence of LVO stroke but are often missed. Simulated patients (SPs) could be an excellent tool to train EMS
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CT hyperdense lesions after endovascular therapy in acute ischemic stroke: imaging findings and clinical significance. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-11-21 Wei Yu,Chao Xia,Bo Tao,Yuan Xiao,Ziyang Gao,Fei Zhu,Qiannan Zhao,Su Lui
Background The hyperdense lesion on non-contrast CT (NCCT) is a common postoperative phenomenon in acute ischemic stroke (AIS) patients who are treated with endovascular therapy (EVT). Both contrast extravasation and hemorrhagic transformation presented hyperdense lesions on NCCT, which are sometimes difficult to distinguish them. Summary of Review Radiographic findings are important for identifying
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Patterns and Implications of Intracranial Atherosclerosis in Anterior and Posterior Circulation Identified by High-Resolution Vessel Wall Imaging. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-11-21 Lu Zheng,Jia Li,Wenjie Yang,Ho-Ching Chloe Lam,K S Lawrence Wong,Winnie Chu,Thomas Wai Hong Leung,Xiangyan Chen
INTRODUCTION Anterior and posterior circulation atheroscleroses differ in vascular risk factors and stroke patterns. Posterior circulation stroke has worse clinical outcomes. However, few studies described the differentiation of plaque features between anterior and posterior circulation atheroscleroses via high-resolution vessel wall imaging (HR-VWI). We aimed to compare the plaque imaging features
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The association between antiplatelet therapy and changes in intraplaque hemorrhage in patients with mild to moderate symptomatic carotid stenosis: a longitudinal MRI study. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-11-20 Mohamed Kassem,Geneviève A J C Crombag,Jens Stegers,Madieke I Liem,Eline Koornstra,Floris H B M Schreuder,Dianne H K van Dam-Nolen,Carlo Lucci,Rob J van der Geest,Mat J Daemen,Anton F W van der Steen,Jeroen Hendrikse,Werner H Mess,Daniel Bos,Joachim E Wildberger,Robert J van Oostenbruggeb,Paul J Nederkoorn,M Eline Kooi
INTRODUCTION Carotid atherosclerotic intraplaque hemorrhage (IPH) predicts stroke. Patients with a history of stroke are treated with antiplatelet agents to prevent secondary cardiovascular events. A positive association between previous antiplatelet use and IPH was reported in a cross-sectional analysis. We investigated changes in IPH over two years in patients who recently started versus those with
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Association between Fibrinogen-to-Albumin Ratio and Adverse Stroke Outcomes among Patients with Acute Ischemic Stroke. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-11-20 Lioyu Yilong,Yuesong Pan,Runhua Zhang,Mengxing Yilong,Haiqiang Qin,Li Meng,ZiLio Li,Hao Li,Yilong Yilong,Xingquan Zhao,Yongjun Yilong,Gaifen Liu
INTRODUCTION Fibrinogen-to-albumin ratio (FAR) is implicated in prothrombotic states and is associated with an increased risk of acute ischemic stroke (AIS). However, studies investigating whether the prothrombotic effect of FAR is associated with long-term adverse outcomes in patients with AIS are lacking. Therefore, we aimed to investigate the association based on The Third China National Stroke
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Prevalence and Prognostic Value of Atrial Cardiopathy in Embolic Stroke of Undetermined Source. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-11-19 Yueyang Wu,Xiaomeng Yang,Jing Jing,Xia Meng,Zixiao Li,Yuesong Pan,Yong Jiang,Hongyi Yan,Xinying Huang,Liping Liu,Xingquan Zhao,Yilong Wang,Hao Li,Yongjun Wang
INTRODUCTION We utilized data from the Third China National Stroke Registry to investigate the prevalence of atrial cardiopathy markers in patients with embolic stroke of undetermined source (ESUS) and to assess their association with death and stroke recurrence. METHODS In China, patients experiencing transient ischemic attack or ischemic stroke were recruited consecutively by the Third China National
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Treatment strategies and prognosis for moderate stroke patients in China. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-11-18 Liyuan Wang,Qi Zhou,Hongqiu Gu,Manjun Hao,Yunyun Xiong,Yongjun Wang
INTRODUCTION Moderate stroke patients with National Institutes of Health Stroke Scale (NIHSS) score of 4-10 and without intravenous thrombolysis or endovascular treatment are basically excluded from current secondary prevention trials. We aimed to explore the effectiveness of mono- vs. dual-antiplatelet (DAPT) treatment strategies against subsequent stroke for these patients in a nationwide cohort
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Intake of marine n-3 polyunsaturated fatty acids and risk of hemorrhagic stroke and its subtypes: a Danish follow-up study. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-11-15 Katrin Hjelmgaard,Christian Sørensen Bork,Søren Lundbye-Christensen,Pernille Lühdorf,Flemming Winther Bach,Erik Berg Schmidt,Kim Overvad,Stine Krogh Venø
BACKGROUND A diet rich in marine n-3 polyunsaturated fatty acids (PUFAs) may lower the risk of coronary heart disease and ischemic stroke. However, the association between intake of marine n-3 PUFAs and risk of hemorrhagic stroke has only been sparsely explored. We aimed to investigate the associations between intake of the major marine n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid
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Asia Pacific Stroke Conference 2023: Advancing Stroke Care in Times of Change. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-11-14 Narayanaswamy Venketasubramanian,Richard Li,Wing-Chi Fong,Thomas Leung,Nijasri C Suwanwela,Byung-Woo Yoon
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Sensitivity and Accuracy of Doppler Ultrasound compared to CT Angiography for the Diagnosis of Carotid Webs: Systematic Review. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-11-11 Miguel Serôdio,Maria Fátima Soares,Tiago Muxagata,Vanessa Almeida,Ana Catarina Fonseca
INTRODUCTION Carotid webs (CaW) are increasingly recognized as a cause of cryptogenic acute ischemic stroke (AIS). Due to the risk of recurrent ischemic stroke associated with CaW, it is important to identify them. Although several studies report digital subtraction angiography (DSA) and computerized tomography angiography (CTA) to be better at diagnosing CaW than Doppler ultrasound (DUS), it remains
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Advances in the study of KRAS in brain arteriovenous malformation. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-11-10 Miao Pang,Guanghao Zhang,Chenghao Shang,Yuhang Zhang,Rundong Chen,Zhe Li,Xin Ding,Guoli Duan,Qiang Li
Background:Brain arteriovenous malformation (bAVM) is an abnormal vascular mass with disordered arteriovenous connection. Endothelial KRAS mutation is common in bAVM. In vivo studies have demonstrated that mutations of KRAS in somatic cells can induce bAVM-like angiogenesis, suggesting that KRAS gene may play a key role in the development and progression of bAVM. Summary:In this article, we will provide
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Radiographic signs of advanced cerebral venous thrombosis negatively modulate the effectiveness of endovascular treatments. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-11-06 Huanwen Chen,Mihir Khunte,Marco Colasurdo,Paul Singh,Ajay Malhotra,Dheeraj Gandhi
INTRODUCTION Endovascular treatment (EVT) is a therapeutic option for cerebral venous thrombosis (CVT); however, its benefit over conservative medical management has not been proven. Whether current patient selection practices are appropriate for EVT is unclear. METHODS This was a nationwide study of the 2016-2020 National Inpatient Sample database. Adult CVT patients and EVT treatments were identified
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Blood pressure variability is associated with Infarct Growth in Acute Ischemic Stroke. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-11-02 Andrew G Woods,Tom Lillicrap,Rebecca Hood,Joseph W Fletcher,Viktor Ranhage,Emil Larsson,Fredrik Cahlin,Katarina Jood,Turgut Tatlisumak,Spratt Garcia-Esperon,Neil J Spratt
Introduction Evidence based blood pressure (BP) targets in acute ischemic stroke are lacking. Previous observational studies have focused on single baseline BP and clinical outcomes, without consideration for dynamic changes. We aim to determine the association between BP parameters including variability, peak, nadir, median and mean during stroke and infarct growth (primary outcome), risk of haemorrhagic
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The main Optimal Post rTpa-Iv Monitoring in Ischemic Stroke Trial (OPTIMISTmain): protocol for a pragmatic, stepped wedge, cluster randomized controlled trial. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-10-26 Menglu Ouyang,Roland Faigle,Xia Wang,Brenda Johnson,Debbie Summers,Pooja Khatri,Laurent Billot,Hueiming Liu,Alejandra Malavera,Paula Munoz-Venturelli,Francisca Gonzalez,Francisca Urrutia,Diana Day,Lili Song,Yi Sui,Candice Delcourt,Thompson Robinson,Alice C Durham,Ahtasam Ebraimo,Wan Asyraf Wan Zaidi,Stephen Jan,Richard I Lindley,Victor C Urrutia,Craig S Anderson
Introduction Careful monitoring of patients who receive intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) is resource-intensive, and potentially less relevant in those with mild degrees of neurological impairment who are at low-risk of symptomatic intracerebral hemorrhage (sICH) and other complications. \ Methods OPTIMISTmain is an international, multicenter, prospective, stepped wedge
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Measurement of GFAP in nasal exudate in the differential diagnosis between ischemic and hemorrhagic stroke. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-10-25 Carmen García-Cabo,Pablo Rioboó-Legaspi,Lorena Benavente-Fernández,Estefanía Costa-Rama,María Teresa Fernández-Abedul,Sergio Calleja-Puerta
INTRODUCTION Differential diagnosis between ischemic stroke (IS) and intracerebral hemorrhage (ICH) is a great challenge. Recently, the discovery of cerebral lymphatic drainage towards the nostrils suggested nasal exudate (NE) as a new source for measure biomarkers from neural damage. We sought to confirm whether glial fibrillary acidic protein (GFAP) levels in NE could identify ICH. METHODS GFAP in
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Hospital-Acquired Infection at Time of Stroke and Cognitive Decline: The Cardiovascular Health Study. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-10-23 Kyril L Cole,Amelia K Boehme,Evan L Thacker,W T Longstreth,Bruce L Brown,Shawn D Gale,Dawson W Hedges,Jacqueline K Anderson,Mitchell S V Elkind
Introduction Hospital-acquired infections (HAIs) after stroke are associated with additional morbidity and mortality, but whether HAIs increase long-term cognitive decline in stroke patients is unknown. We hypothesized that older adults with incident stroke with HAI experience faster cognitive decline than those having stroke without HAI and those without stroke. Methods We performed a longitudinal
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HMGB1 induced oxidative stress and Inflammation in endothelial cells exposed to Impinging Flow. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-10-20 Huaxin Zhu,Yanyang Zeng,Jiacong Tan,Meihua Li,Yeyu Zhao
BACKGROUND Oxidative stress and inflammation contribute to many aspects of the pathological processes involved in intracranial aneurysm (IA). However, the underlying mechanism for inducing oxidative stress and inflammation under impinging flow remains unclear. Accumulating evidence has shown that High mobility group box-1 (HMGB1) is associated with oxidative stress-related chronic diseases and inflammatory
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Spectrum of Cerebrovascular disease in Scleroderma: A Case Series and Systematic Review. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-10-13 Michela Rosso,Srinath Ramaswamy,David Aharonoff,Murat Inanç,Steven R Levine
Introduction Central nervous system involvement in scleroderma has traditionally been considered uncommon. Recent studies suggest that scleroderma might be associated with an increased risk of cerebrovascular disease (CBVD), independent of conventional cardiovascular risk factors. We present a case series and a systematic review to capture the spectrum of CBVD in scleroderma, through a detailed description
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Revisiting the predictive role of truncal-type occlusion sign for acute large vessel stroke treated by endovascular thrombectomy: A scoping review. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-10-12 Bingyang Zhao,Wenzhao Liang,Xinzhao Jiang,Zhongyu Zhao,Lei Yan,Jing Mang,Zhongxin Xu
Background and purpose The truncal type occlusion (TTO) sign observed during endovascular thrombectomy (EVT) is thought to predict the etiology and prognosis of acute ischemic stroke (AIS) due to large vessel occlusion (LVO). However, the interpretation of the present results and the clinical utility of this sign needs further investigation. This scoping meta-review aimed to assess the predictive value
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Progress of Ultrasound Techniques in the Evaluation of Carotid Vulnerable Plaque Neovascularization. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-10-09 Penghui Zeng,Qing Zhang,Xiaowen Liang,Min Zhang,Dan Luo,Zhiyi Chen
BACKGROUND The rupture and detachment of unstable plaques in the carotid artery can cause embolism in the cerebral artery, leading to acute cerebrovascular events. Intraplaque neovascularization (IPN) is a very important contributor to carotid plaque instability, and its evolution plays a key role in determining the outcome of vulnerable plaques. Ultrasound techniques, represented by contrast-enhanced
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Efficacy and Safety of Mechanical Thrombectomy in Elderly and Non-Elderly Patients with Large Vessel Occlusion Stroke A Systematic Review and Meta-Analysis. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-10-09 Aisha Ali,Fernando D Testai,Gabriela Trifan
INTRODUCTION Mechanical thrombectomy (MT) is recommended for large vessel occlusion (LVO) stroke. However, most of the studies that investigated the superiority of MT over best medical management (BMM) alone included preponderantly non-elderly patients. Thus, there is uncertainty in relation to the efficacy of MT in the elderly. We aim to compare the effect of BMM to BMM plus (MT) among elderly and
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8th World Intracranial Hemorrhage Conference (WICH 2023). Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-10-05 Mojca Rodic
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Serial quality of life assessment around screening for familial intracranial aneurysms: a prospective cohort study. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-10-01 Liselore A Mensing,Keneshka Atash,Gabriel Je Rinkel,Ynte M Ruigrok
INTRODUCTION Screening for intracranial aneurysms (IAs) is cost-effective in first-degree relatives of aneurysmal subarachnoid haemorrhage (aSAH) patients, but its psychosocial impact is largely unknown. PATIENTS AND METHODS A consecutive series of persons aged 20-70 years visiting the University Medical Centre Utrecht for first screening for familial IA was approached between 2017-2020. E-questionnaires
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Clinical significance of microRNA-330-3p in plasma level for acute cerebral infarction. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-09-29 Huiru Jian,Fei Wang,Ying Wang,Liping Dou
INTRODUCTION The present study was to investigate the clinical role of miR-330-3p in acute cerebral infarction (ACI), including its diagnostic and prognostic potential. Preliminary exploration of its target genes was archived by bioinformatics analysis. METHODS miR-330-3p in plasma of the patients with ACI and controls were quantified by real-time quantitative PCR. The one-month prognosis of the ACI
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Association between Triglyceride-Glucose Index and 1-year Recurrent Stroke after Acute Ischemic Stroke: Results from the Xi'an Stroke Registry Study of China. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-09-27 Weiyan Guo,Zhongzhong Liu,Pei Liu,Qingli Lu,Qiaoqiao Chang,Mi Zhang,Yan Huo,Xuemei Lin,Linna Peng,Tong Liu,Yinfang Yan,Zhen Lei,Yuanji Wang,Congli Huang,Dandan Zhang,Fang Wang,Songdi Wu
INTRODUCTION The triglyceride-glucose (TyG) index is reported to be related to poor functional outcomes and all-cause mortality post-stroke. However, the association between TyG index and recurrent stroke after acute ischemic stroke (AIS) has not been well described. We aimed to identify whether the TyG index was associated with 1-year recurrent stroke after AIS. METHODS Baseline patient information
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Factors associated with discharge against medical advice among acute stroke patients: Analysis of the Nationwide Emergency Department Sample. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-09-21 Karan Patel,Kamil Taneja,Jared Wolfe,Solomon Oak,Christopher Favilla,James E Siegler
BACKGROUND Patients discharged against medical advice have been shown to have worse outcomes across a host of different conditions. However, risk factors related to an increased odds of discharge against medical advice remain understudied in patients who suffer from acute cerebral infarction. METHODS We retrospectively examined the 2019 National Emergency Department Sample Database for stroke patients
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Cognitive Impairment Is Associated with New-Onset Stroke: Evidence from a Nationwide Prospective Cohort Study. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-09-20 Tian Qiao,Hongzhuan Lu,Xianghua Wang,Xiang Wang
INTRODUCTION Stroke is closely related to cognitive function, and many patients experience cognitive impairment after stroke; however, whether cognitive impairment is associated with an increased risk of stroke remains inconclusive. This study aims to investigate whether cognitive impairment is associated with new-onset stroke (first ever nonfatal stroke) using a national prospective study. METHODS
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Three-dimensional arterial spin labeling for the evaluation of the cerebral hemodynamics in ischemic and hemorrhagic Moyamoya disease. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-09-18 Hao Bian,Lei Zhang,Junping Wang
INTRODUCTION Moyamoya disease (MMD) is a vascular disease with significant risk of mortality due to ischemia or hemorrhage in the brain. The goal of the study was to explore three-dimensional arterial spin labeling (3D-ASL) to improve evaluation of cerebral hemodynamics in patients with MMD. METHODS Our study included 54 cases of ischemic MMD and 42 cases of hemorrhagic MMD. Dynamic susceptibility
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A Knowledge Map of the Relationship between Diabetes and Stroke: A Bibliometric Analysis Study. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-09-18 Yitong Liang,Tingting Fan,Min Bai,Meng Tang,Na Cui,Yue Chen,Jinyi Chen,Jingwen Wang,Yue Guan
INTRODUCTION The correlation between diabetes and stroke has been studied extensively in epidemiological research. Here we used bibliometric software to visualize and analyze the literature related to diabetic stroke to provide an overview of the current state of research, hot spots, and future trends in the field. METHODS Based on the Web of Science Core Collection(WoSCC) database, we collected studies
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The safety and efficacy of emergency stenting during bridging therapy: A Single-Center Retrospective Study. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-09-15 Zhengwen Chen,Yaoyu Ying,Xiaojian Lu,Shuqing Sun,Qingfeng Huang,Junjie Shao,Peicheng Li,Long Chen
INTRODUCTION To investigated the safety and efficacy of emergency stenting for patients with ischemic stroke treated with bridging therapy. METHODS Patients with onset of stroke who underwent bridging therapy were included in the two groups with emergency stenting (ESG) and without stenting (NSG). To avoid the bias due to confounding variables, subjects were further assigned in two groups using 1:1
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Variation in Ischemic Stroke Payments in the USA: A Medicare Beneficiary Study. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-09-15 Ana Paula Beck da Silva Etges,Ana Claudia de Souza,Porter Jones,Harry Liu,Xiaoran Zhang,Miriam Marcolino,Carisi Anne Polanczyk,Sheila Ouriques Martins,Gisele Sampaio,Vasileios Arsenios Lioutas
INTRODUCTION The growing cost of stroke care has created the need for outcome-oriented and cost-saving payment models. Identifying imbalances in the current reimbursement model is an essential step toward designing impactful value-based reimbursement strategies. This study describes the variation in reimbursement fees for ischemic stroke management across the USA. METHODS This Medicare Fee-For-Service
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Osteopontin is associated with dementia in the presence of cerebral small vessel disease. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-09-06 Smita Ghare,Hannah Gardener,Taylor Ariko,Jose Gutierrez,Clinton B Wright,Ronald B Goldberg,Mitchell S V Elkind,Gregory E Cooper,Christopher B Shields,Shirish Barve,Tatjana Rundek
BACKGROUND Osteopontin (OPN) is a proinflammatory cytokine that has been recently implicated in neuroinflammation and neurodegeneration. We hypothesized that an increase in plasma osteopontin is a deleterious neuroinflammatory marker in people with dementia and cerebral small vessel disease (CSVD). METHODS A pilot study was conducted on participants in the Northern Manhattan Study (NOMAS). Three groups
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Artificial Intelligence and Cerebrovascular Diseases: ChatGPT model. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-09-02 Erman Altunisik
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Effect of Time Window on Endovascular Thrombectomy with or without Intravenous Thrombolysis in Acute Ischemic Stroke: Results from DIRECT-MT. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-08-18 Qiwen Deng,Lei Zhang,Yukai Liu,Feng Zhou,Zhenhua Yuan,Xixi Wang,Jie Gao,Pengfei Yang,Yongwei Zhang,Pengfei Xing,Zifu Li,Bo Hong,Hongxing Han,Huaizhang Shi,Hongchao Shi,Jianmin Liu,
INTRODUCTION Whether time window affects the intravenous thrombolysis (IVT) effect before endovascular thrombectomy (EVT) is uncertain. We aimed to investigate the effect of different time windows (0-3 h and >3-4.5 h from stroke onset to randomization) on clinical outcomes of EVT with or without IVT in a subgroup analysis of DIRECT-MT. METHODS The primary outcome was the 90-day modified Rankin Scale
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Aortic stiffness is independently associated with intracranial carotid artery calcification in patients with ischemic stroke. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-08-17 Jacek Gozdalski,Tomasz K Nowicki,Mariusz Kwarciany,Kamil Kowalczyk,Krzysztof Narkiewicz,Dariusz Gasecki
Background and aims Intracranial carotid artery calcification (ICAC), as a strong contributor to the occurrence of ischemic stroke, might be present in the medial or intimal arterial layer. Traditional cardiovascular risk factors (CVRFs) are associated with ICAC; however, its association with new markers of vascular function are less understood. The paper aims to evaluate the relationship between carotid-femoral
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Liver enzymes and the risk of stroke among the general Japanese population: a prospective cohort study. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-08-17 Ahmed Arafa,Yoshihiro Kokubo,Rena Kashima,Chisa Matsumoto,Masatoshi Koga
BACKGROUND Stroke is a major cause of morbidity and mortality. Liver enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (GGT), are markers of liver diseases with potential cardiovascular implications. OBJECTIVE This study aimed to investigate the prospective association between liver enzymes and stroke risk. METHODS We analyzed data from 3,379
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Cilostazol versus Aspirin or Clopidogrel for Reducing Post-Stroke Aspiration Pneumonia: A Nationwide Retrospective Cohort Study. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-08-16 So Sato,Hayato Yamana,Ryosuke Kumazawa,Hideaki Watanabe,Asahi Fujita,Hiroki Matsui,Kiyohide Fushimi,Hideo Yasunaga
INTRODUCTION The association between the use of cilostazol as a post-stroke antiplatelet medication and a reduction in post-stroke pneumonia has been suggested. However, whether cilostazol has a greater preventive effect against post-stroke aspiration pneumonia (AP) than other antiplatelet medications remains unclear. Thus, this study aimed to evaluate whether cilostazol has a greater preventive effect
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Possible Influence of Ethnicity on CT Perfusion Parameter Thresholds in Acute Ischemic Stroke. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-08-07 Yohanna Kusuma,Benjamin Clissold,Peter Riley,Paul Talman,Andrew Wong,Leonard Yeo Leong Litt,Mursyid Bustami,Lyna Soertidewi Kiemas,Indah Aprianti Putri,M Arief R Kemal,Reza A Arpandy,Melita Melita,Bernard Yan,Paul Yielder
Introduction Tissue at risk, as estimated by CT perfusion utilizing Tmax+6, correlates with final infarct volume (FIV) in acute ischemic stroke (AIS) without reperfusion. Tmax thresholds are derived from Western ethnic populations but not from ethnic Asian populations. We aimed to investigate the influence of ethnicity on Tmax thresholds. Methods From a clinical-imaging registry of Australian and Indonesian
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Dietary Flavonoid Intake and Carotid Calcification in Patients with Ischemic Stroke. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-07-31 Tao Mou,Xuerong Jia,Min Peng,Xiang Li,Yaqian Xia,Yantong Chen,Qing Wang,Xiaoke Wang,Xinfeng Liu,Gelin Xu
INTRODUCTION Owing to the antioxidant and anti-inflammatory effects, flavonoids can influence the initiation and development of atherosclerosis, but the underlying mechanisms remain largely undetermined. This study aimed to evaluate the associations between dietary flavonoids and carotid calcification in patients with ischemic stroke. METHODS This study screened consecutive patients with ischemic stroke
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CT-based and CTA-based posterior circulation ASPECTS in acute basilar artery occlusion: An Agreement Study. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-07-31 Feng Zhang,Zhixin Huang,Wei Lu,Zi Wang,Yanan Lu,Meng Wang,Pan Zhang,Miaomiao Hu,Lulu Xiao,Xinfeng Liu,Wen Sun
BACKGROUND AND PURPOSE The purpose of the present study was to evaluate the agreement on pc-ASPECTS (posterior circulation Acute Stroke Prognosis Early Computed Tomography Scores) based on non-contrast CT (NCCT) and CT angiography (CTA) source images in patients with acute basilar artery occlusion (BAO). METHODS We prospectively enrolled consecutive patients with acute BAO from January 2022 to August
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Detection of Atrial Fibrillation After Ischemic Stroke with an Insertable Cardiac Monitor: A Systematic Review and Individual Patient Data Meta-Analysis of Randomised Clinical Trials. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-07-29 Zi Yi Wong,Linus Zh Yuen,Y K Tan,C Xy Goh,Yao Neng Teo,Jamie Sy Ho,Swee Chong Seow,Edward Cy Lee,Hock-Luen Teoh,Leonard Ll Yeo,Ching-Hui Sia,Benjamin Yq Tan
OBJECTIVE In ischemic stroke patients, we compared the use of insertable cardiac monitor (ICM) versus non-ICM methods of cardiac monitoring on the incidence of atrial fibrillation (AF) detection and other clinical outcomes. BACKGROUND Current guidelines recommend the routine use of 12-lead electrocardiography or Holter monitoring for AF detection after ischemic stroke. Recent randomised controlled
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Effect of needle-to-puncture time on reperfusion outcome in acute ischemic stroke. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-07-26 Chih-Hao Chen,Fouzi Bala,Mohamed Najm,Ibrahim Alhabli,Nishita Singh,Nima Kashani,Rosalie V McDonough,MacKenzie Horn,Jilian Stang,Andrew M Demchuk,Bijoy K Menon,Michael D Hill,Mohammed A Almekhlafi
Introduction To investigate the impact of time interval between start of intravenous thrombolysis (IVT) to start of endovascular thrombectomy (EVT) on stroke outcomes. Methods Data from the Quality Improvement and Clinical Research (QuICR) provincial stroke registry from Alberta, Canada was used to identify stroke patients who received IVT and EVT from January 2015 to December 2019. We assessed the
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Effects of polyunsaturated fatty acids serum levels on vascular dementia: A two-sample Mendelian randomization study. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-07-21 Shanshan Chen,Ruyi Cong,Yongbo Chen,Xiaoliang Li,Xiaoyu Zhang,Guohua Wang,Xiuyu Pang,Weijia Xing,Youxin Wang,Xizhu Xu
INTRODUCTION Several observational studies have indicated that polyunsaturated fatty acids serum levels (PUFAs) are associated with vascular dementia (VaD), but their causal relationships remain elusive. Therefore, we attempted to evaluate the causal effect of PUFAs on VaD in a two-sample Mendelian randomization (MR) analysis by using summary statistics from aggregated genome-wide association studies
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The Epidemic characteristics of stroke death from 2012 to 2021 in Chongqing, China. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-07-12 Xianbin Ding,Rui Ding,Liling Chen,Yan Jiao,Jie Xu,Guiting Zhang,Qiuting Wang,Jiaxi Xie,Yang Gao,Xianxian Yang
Introduction Stroke has become a major disease that threatens the global population's health and is a major public health problem that needs to be solved in China. Therefore, it is essential to analyze the trend of the mortality of stroke and its epidemic characteristic of stroke death. Methods Death cases of stroke were reported to the national death registry system by the medical staff of all medical
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Circadian Rhythm Disturbance in Acute Ischemic Stroke Patients and Its Effect on Prognosis. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-07-07 Si-Yuan Yu,Qian Sun,Sheng-Nan Chen,Fen Wang,Rui Chen,Jing Chen,Chun-Feng Liu,Jie Li
INTRODUCTION Poststroke sleep disturbances are common and can affect stroke outcomes, but the clinical studies mainly focus on breathing-related sleep disorders, while the bidirectional impact of circadian rhythm dysfunction in ischemic stroke remains unknown. This study observed the characteristics of melatonin secretion in acute ischemic stroke patients and evaluated whether melatonin rhythm impacts
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Regional Initiatives to Empower Young Medical Doctors: The Young Stroke Latin American Task Force (ALATAC). Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-07-03 Julieta Rosales,Angel Basilio Corredor-Quintero,Leonardo Augusto Carbonera,Matías J Alet,Pablo Amaya,Vanessa Cano-Nigenda,Miguel A Barboza,Victor Navia,Claudio Alejandro Jiménez,Rodrigo Guerrero,Ana Claudia De Souza
Local and regional cooperation may strengthen efforts to reduce stroke burden in low-resource settings. New generations full of energy, honoring the past achievements of mentors and current stroke leaders, have the potential to stimulate stroke research, and prevention and implement the available evidence-based treatments. This article presents how a local initiative focused on young stroke professionals
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Timing of initiation of acute stroke rehabilitation and management corresponding to complications at primary stroke centers in Japan: a nationwide cross-sectional web-based questionnaire survey. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-07-03 Koichi Oki,Makoto Nakajima,Tetsuo Koyama,Naoki Oyama,Masatoshi Koga,Makoto Hayase,Tsuyoshi Ohta,Tomohiro Omori,Koichi Matsumoto,Yasuyuki Iguchi,Shigeru Fujimoto,Wataru Kakuda,Kuniaki Ogasawara
INTRODUCTION Many guidelines now recommend early rehabilitation for acute stroke patients. However, evidence remains lacking regarding the specific timings for initiation of various rehabilitation steps and management when complications are encountered in acute stroke rehabilitation. This survey aimed to investigate actual clinical situations in acute stroke rehabilitation in Japan, to improve the
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Association between Rapid Ventricular Response and Stroke Outcomes in Atrial Fibrillation-Related Cardiac Embolic Stroke. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-07-03 Sang Hee Ha,Soo Jeong,Jae Young Park,So Young Yang,Myung-Jin Cha,Min-Soo Cho,Ji Sung Lee,Min-Ju Kim,Jun Young Chang,Dong-Wha Kang,Sun U Kwon,Bum Joon Kim
INTRODUCTION Patients with atrial fibrillation-related stroke (AF-stroke) are prone to developing rapid ventricular response (RVR). We investigated whether RVR is associated with initial stroke severity, early neurological deterioration (END) and poor outcome at 3 months. METHODS We reviewed patients who had AF-stroke between January 2017 and March 2022. RVR was defined as having heart rate >100 beats
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Dietary Iron Restriction Protects Against Aneurysm Rupture in a Mouse Model of Intracranial Aneurysm. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-06-08 Toru Kawakatsu,Yoshinobu Kamio,Hiroshi Makino,Kazuya Hokamura,Ryo Imai,Sho Sugimura,Tetsuro Kimura,Hisaya Hiramatsu,Kazuo Umemura,Tomoki Hashimoto,Kazuhiko Kurozumi
INTRODUCTION Iron accumulation in vessel walls induces oxidative stress and inflammation, which can cause cerebrovascular damage, vascular wall degeneration, and intracranial aneurysmal formation, growth, and rupture. Subarachnoid hemorrhage from intracranial aneurysm rupture results in significant morbidity and mortality. This study used a mouse model of intracranial aneurysm to evaluate the effect
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World Stroke Organization Brain and hEart globAl iniTiative Program. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-06-05 Luciano A Sposato,Sheila Martins,Jan F Scheitz,Sara Aspberg,M Edip Gurol,Mohamed Abdalla,Antonio Arauz,Vanessa Cano-Nigenda,Paul Fiorilli,Carsten Israel,Kengo Kusano,Ossama Mansour,Steven R Messé,Arthur Pille,Thaís Secchi,Carisi Polanczyk,Andreia Biolo,Ismail Ramadan,Ashraf Sallam,Wolf Schäbitz,Kazunori Toyoda,Sharon Valencia,Shang Wang,Yunyun Xiong,Amr Zaki,Gustavo Saposnik,Marc Fisher,M Cecilia Bahit
INTRODUCTION The World Stroke Organization (WSO) Brain & Heart Task Force developed The Brain & hEart globAl iniTiative (BEAT), a pilot feasibility implementation program aimed at establishing clinical collaborations between cardiologists and stroke physicians who work at large healthcare facilities. METHODS The WSO BEAT pilot project focused on atrial fibrillation (AF) and patent foramen ovale (PFO)
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The Single-Matrix Digit Cancellation Test (SMDCT), a screener for selective attention deficits: standardization in an Italian population sample and clinical usability in acute stroke patients. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-06-01 Fabrizio Pasotti,Edoardo Nicolò Aiello,Alessandra Bollani,Matteo Querzola,Sara Cozzi,Francesca Manfrin,Stefania Bruno,Barbara Poletti,Nicola Ticozzi,Vincenzo Silani,Gabriella Bottini
INTRODUCTION This study aimed at validating and providing Italian norms for the Single-Matrix Digit Cancellation Test (SMDCT), a cancellation task to screen for selective attention deficits, as well as providing clinical usability evidence for it in acute stroke patients. METHODS The SMDCT stimulus is a specular, 4-quadrant, horizontally oriented matrix, across which target distribution is homogeneous
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Associations of Cerebral Small Vessel Disease on the Features of Hematoma and Hematoma Expansion in Intracerebral Hemorrhage. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-06-01 Chih-Hao Chen,Shuo-Fu Chen,Hsin-Hsi Tsai,Ya-Fang Chen,Sung-Chun Tang,Jiann-Shing Jeng
INTRODUCTION Several early noncontrast CT (NCCT) signs of spontaneous intracerebral hemorrhage (ICH) can predict hematoma expansion (HE). However, the associations of underlying cerebral small vessel disease (SVD) on early NCCT signs and HE have been less explored. METHODS We conducted an analysis of all patients with spontaneous supratentorial ICH and received follow-up imaging between 2016-2020 at
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Smokers with Elevated Glycated Albumin Could Not Benefit from Dual Antiplatelet Therapy After Minor Stroke or Transient Ischemic Attack. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-06-01 Hongyu Zhou,Yuesong Pan,Weiqi Chen,Yue Suo,Hongyi Yan,Xia Meng,Xingquan Zhao,Liping Liu,Hao Li,Yongjun Wang
INTRODUCTION To investigate the impact of smoking on dual antiplatelet therapy in patients with minor stroke or transient ischemic attack (TIA) under different glycated albumin (GA) levels. METHODS We analyzed data from the Clopidogrel in High-risk patients with Acute Nondisabling Cerebrovascular Events (CHANCE) trial. A subgroup of 3044 patients with baseline GA levels was included and categorized
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Thrombolysis for acute wake-up and unclear onset strokes with alteplase at 0.6 mg/kg in clinical practice: THAWS2 Study. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-06-01 Sohei Yoshimura,Masatoshi Koga,Takashi Okada,Manabu Inoue,Kaori Miwa,Mayumi Fukuda-Doi,Rei Kondo,Takeshi Inoue,Masahiko Ichijo,Masafumi Ohtaki,Yoshinari Nagakane,Ryo Itabashi,Nobuyuki Sakai,Kazumi Kimura,Kenji Kamiyama,Yoshiaki Shiokawa,Yoshiki Yagita,Toru Iwama,Yusuke Yakushiji,Masayoshi Kusumi,Tetsu Yamaki,Jyunichi Uemura,Asuka Yasuura,Shouhei Noshiro,Daiki Fukunaga,Yukako Yazawa,Junya Aoki,Masaaki
INTRODUCTION The aim of this study was to determine the safety and efficacy of intravenous (IV) alteplase at 0.6 mg/kg for patients with acute wake-up or unclear onset strokes in clinical practice. METHODS This multicenter observational study enrolled acute ischemic stroke patients with last-known-well time >4.5 h who had mismatch between DWI and FLAIR and were treated with IV alteplase. The safety
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Interventions for behaviour change and self-management of risk in stroke secondary prevention: an overview of reviews. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-05-25 Patricia Hall,Maggie Lawrence,Catherine Blake,Olive Lennon
INTRODUCTION Optimised secondary prevention strategies that include lifestyle change are recommended after stroke. Whilst multiple systematic reviews address behaviour-change interventions, intervention definitions and associated outcomes differ between reviews. This overview of reviews addresses the pressing need to synthesise high-level evidence for lifestyle-based, behavioural and/or self-management
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Development and validation of a prediction model for 30-day mortality and functional outcome in patients with primary brainstem hemorrhage. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-05-25 Chengwei Cai,Chuangnan Yan,Shuxin Chen,Wenpeng Yang,Yiping Huang,Junqiang Ma,Hongwu Xu
INTRODUCTION Primary brainstem hemorrhage (PBSH) is the most fatal subtype of intracerebral hemorrhage and associated with poor prognosis. We aimed to develop a prediction model for predicting 30-day mortality and functional outcome in patients with PBSH. METHODS We reviewed records of 642 consecutive patients with first-time PBSH from three hospitals between 2016 and 2021. Multivariate logistic regression
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The diet quality of Australian stroke survivors in a community setting. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-05-24 Karly Zacharia,Emily Ramage,Margaret Galloway,Meredith Burke,Graeme J Hankey,Elizabeth Lynch,Catherine M Said,Coralie English,Amanda Patterson,Lesley Macdonald-Wicks
Background Diet quality is a marker of how closely eating patterns reflect dietary guidelines. The highest tertile for diet quality scores is associated with 40% lower odds of first stroke compared with the lowest tertile. Little is known about the diet of stroke survivors. We aimed to assess dietary intake and quality of Australian stroke survivors. Method Stroke survivors enrolled in the ENAbLE pilot
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Partial Meal Replacement for Weight Loss after Stroke: Results of a Pilot Clinical Trial. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-05-15 Jennifer Dearborn Tomazos,Catherine Viscoli,Hardik Amin,Laurel Jean Lovelett,Jessica Rivera,Anum Gull,Walter N Kernan
INTRODUCTION Over half of patients with acute ischemic stroke are overweight or obese as defined by a body mass index (BMI) ≥25 kg/m2. Professional and government agencies recommend weight management for these persons to improve risk factors for cardiovascular disease, including hypertension, dyslipidemia, vascular inflammation, and diabetes. However, approaches to weight loss have not been adequately
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Topographic consideration on the occurrence of ipsilesional facial paresis in lateral medullary infarction. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-05-10 Yong Kyun Kim,Yong Bum Kim,Bum Chun Suh,Yun Hyeong Jeong,Soei Ann,Pil Wook Chung
INTRODUCTION The purpose of this study was to identify course of corticobulbar tract and factors associated with the occurrence of facial paresis (FP) in lateral medullary infarction (LMI). METHODS Patients diagnosed with LMI who were admitted totertiary hospital were retrospectively investigated and divided into two groups based on the presence of FP. FP was defined as grade II or more by the House-Brackmann
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Dental Caries a Risk Factor for Intracerebral Hemorrhage. Cerebrovasc. Dis. (IF 2.9) Pub Date : 2023-05-09 Elizabeth A LaValley,Souvik Sen,Emma Mason,Makenzie Logue,Tushar Trivedi,Kevin Moss,James Beck,Wayne Rosamond,Rebecca F Gottesman
INTRODUCTION Streptococcus mutans is a known cause of dental caries that contains a collagen-binding protein, Cnm, and exhibits inhibition of platelet aggregation and matrix metalloproteinase-9 activation. This strain has been linked to aggravation of experimental intracerebral hemorrhage (ICH) and may be a risk factor for ICH.The purpose of this study was to test the association between dental caries