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A Comparative Study on the Difference of Blood Pressure Criteria and the Difference in Blood Pressure Measurement Among Children and Adolescents in China, the United States, and Europe Am. J. Hypertens. (IF 3.2) Pub Date : 2024-03-15 Liwang Gao, Xi Wang, Xia Wang, Hongbo Dong, Jie Mi
OBJECTIVE To compare the difference of blood pressure criteria and the difference in blood pressure measurement among children and adolescents. METHODS The latest blood pressure criteria for children and adolescents in China, the normal blood pressure standard the United States, and Europe have been used to calculate blood pressure differences for the same age, gender, and height. Based on 3 blood
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Estimated pulse wave velocity and cognitive outcomes: A post hoc analysis of SPRINT-MIND Am. J. Hypertens. (IF 3.2) Pub Date : 2024-03-14 Peng Hao, Siting Feng, Min Suo, Shen Wang, Keyang Zheng, Xiaofan Wu
Background Arterial stiffness has been confirmed to be associated with cognitive impairment. Carotid-femoral pulse wave velocity (cfPWV) is widely regarded as the gold standard for assessing arterial stiffness, yet it is not readily accessible. In response, the use of estimated pulse wave velocity (ePWV) has been proposed as a more accessible and cost-effective alternative. ePWV not only offers ease
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Changes in self-measured blood pressure monitoring use in 14 states from 2019 to 2021 – Impact of the COVID-19 pandemic Am. J. Hypertens. (IF 3.2) Pub Date : 2024-03-12 Jing Fang, Wen Zhou, Donald K Hayes, Hilary K Wall, Gregory Wozniak, Alina Chung, Fleetwood Loustalot
Background Self-measured blood pressure monitoring (SMBP) is an important out-of-office resource that is effective in improving hypertension control. Changes in SMBP use during the COVID-19 pandemic have not been described previously. Methods Behavioral Risk Factor Surveillance System (BRFSS) data were used to quantify changes in SMBP use between 2019 (prior COVID-19 pandemic) and 2021 (during COVID-19
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Aortic calcification is associated with the difference between invasive central and cuff-measured brachial blood pressure in chronic kidney disease Am. J. Hypertens. (IF 3.2) Pub Date : 2024-03-11 Jakob Nyvad, Kent Lodberg Christensen, Gratien Andersen, Mark Reinhard, Michael Maeng, Sebastian Nielsen, Martin Bjergskov Thomsen, Jesper Møller Jensen, Bjarne Linde Nørgaard, Niels Henrik Buus
Objective Chronic kidney disease (CKD) is associated with accelerated vascular calcification and increased central systolic blood pressure when measured invasively (invCSBP) relative to cuff-based brachial systolic blood pressure (cuffSBP). The contribution of aortic wall calcification to this phenomenon has not been clarified. We therefore examined the effects of aortic calcification on cuffSBP and
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Afferent renal denervation attenuates sympathetic over activation from the paraventricular nucleus in spontaneously hypertensive rats Am. J. Hypertens. (IF 3.2) Pub Date : 2024-03-09 Kun-Hui Li, Jie-Min Lin, Si-Qi Luo, Min-Yan Li, Yi-Yong Yang, Meng-Meng Li, Pan-Yan Xia, Jin-Zi Su
The effectiveness of Renal Denervation (RDN) in reducing blood pressure and systemic sympathetic activity in hypertensive patients has been established. However, the underlying central mechanism remains unknown. This study aimed to investigate the role of RDN in regulating cardiovascular function via the central Renin-Angiotensin System (RAS) pathway. Ten-week-old Spontaneously Hypertensive Rats (SHR)
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Real-world Impact of Blood Pressure Control in Patients With Apparent Treatment-Resistant or Difficult-to-control Hypertension and Stages 3 and 4 Chronic Kidney Disease Am. J. Hypertens. (IF 3.2) Pub Date : 2024-03-04 George Bakris, Cindy Chen, Alicia K Campbell, Veronica Ashton, Lloyd Haskell, Mukul Singhal
BACKGROUND Chronic kidney disease (CKD) is a common comorbidity in patients with apparent treatment-resistant hypertension (aTRH). We assessed clinical outcomes, healthcare resource utilization events, and costs in patients with aTRH or difficult-to-control hypertension and stage 3-4 CKD with uncontrolled versus controlled blood pressure (BP). METHODS This retrospective cohort study used linked IQVIA
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Cardio-Ankle Vascular Index As A Marker Of Left Ventricular Hypertrophy In Treated Hypertensives: Findings From The Pamela Study Am. J. Hypertens. (IF 3.2) Pub Date : 2024-03-02 Cesare Cuspidi, Rita Facchetti, Fosca Quarti-Trevano, Raffaella Dell’Oro, Giuseppe Mancia, Guido Grassi
Background Findings regarding the association between Cardio-Ankle Vascular Index (CAVI) and cardiac hypertension-mediated organ damage (HMOD), such as left ventricular hypertrophy (LVH) assessed by echocardiography, in elderly hypertensive patients are scanty. We sought to investigate this issue in the hypertensive fraction of the general population treated with anti-hypertensive drugs enrolled in
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A 120-Minute Saline Infusion Test For The Confirmation Of Primary Aldosteronism: A Pilot Study Am. J. Hypertens. (IF 3.2) Pub Date : 2024-02-20 T Golani, J Bleier, A Kaplan, T Hod, Y Sharabi, A Leibowitz, E Grossman, G Shlomai
Background The saline infusion test (SIT) to confirm primary aldosteronism requires infusing two liters of normal saline over 240 minutes. Previous studies raised concerns regarding increased blood pressure and worsening hypokalemia during SIT. We aimed to evaluate the diagnostic applicability of a SIT that requires one liter of saline infusion over 120 minutes. Methods A cross-sectional study, including
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Effect of Heart-Healthy Dietary Patterns on Blood Pressure: A Systematic Review and Meta-analysis Am. J. Hypertens. (IF 3.2) Pub Date : 2024-02-17 Xueyan Jiao, Kunpeng Song, Ning Zhang, Luyao Liu, Yifan Zhang, Yun Chen, Zhenzhen Lan, Shutong Liu, Xincan Liu
OBJECTIVE To systematically evaluate the antihypertensive effect of dietary patterns of blood pressure management. METHODS The researchers searched the following databases: PubMed, Embase, the Cochrane Library, Web of Science, Scopus, China Knowledge Network, China Biomedical Literature Service, Wanfang Database, and Wipu.com by computer. Search for randomized controlled trials (RCTs) on the effects
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No increase in masked hypertension prevalence in children with sickle cell disease in France Am. J. Hypertens. (IF 3.2) Pub Date : 2024-02-07 Plamen Bokov, Berengere Koehl, Chérine Benzouid, Suzanne Verlhac, Florence Missud, Malika Benkerrou, Christophe Delclaux
Objectives An important prevalence (32-45%) of masked hypertension has been reported in children with sickle cell disease (SCD). Systemic arterial rigidity has been associated with stroke in SCD. Stroke screening is well-established using transcranial Doppler (TCD) ultrasound. The objectives of our proof-of-concept study in childhood SCD were to evaluate the prevalence of hypertension and its relationships
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Association of Variability and Hypertensive Loads in 24-h Blood Pressure with Mortality and Cardiovascular Risk Am. J. Hypertens. (IF 3.2) Pub Date : 2024-01-31 Jesus D Melgarejo, Dhrumil Patil, Luis J Mena, Kristina P Vatcheva, Jose A Garcia, Claudia L Satizabal, Carlos A Chavez, Rosa V Pirela, Egle Silva, Gustavo Calmon, Joseph H Lee, Joseph D Terwilliger, Sudha Seshadri, Gladys E Maestre
Background Evidence shows that high 24-h blood pressure (BP) variability increases cardiovascular risk. We investigated whether 24-h BP variability relates to mortality and cardiovascular risk due to inherent variability and/or hypertensive loads in 24-h BP. Methods A total of 1050 participants from the Maracaibo Aging Study (mean age, 66y; women, 67.2%) underwent 24-h ambulatory BP monitoring and
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Three-Year Cardiovascular Outcomes of Telmisartan in Patients with Hypertension: An Electronic Health Record–Based Cohort Study Am. J. Hypertens. (IF 3.2) Pub Date : 2024-01-29 Yunjin Yum, Ju Hyeon Kim, Hyung Joon Joo, Yong Hyun Kim, Eung Ju Kim
Background Telmisartan exhibits superior efficacy in controlling 24-hour blood pressure (BP) compared with other angiotensin receptor blockers (ARBs). However, data on its cardiovascular effects in patients with hypertension are limited. This study aimed to evaluate the cardiovascular outcomes in patients taking telmisartan compared to those taking other ARBs. Methods This multicenter retrospective
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Apparent Treatment-Resistant Hypertension in the First Year Associated with CV Mortality in PD Patients Am. J. Hypertens. (IF 3.2) Pub Date : 2024-01-22 Qingyao Zhu, Zhihao Huo, Fang Zeng, Nirong Gong, Peiyi Ye, Jianyi Pan, Yaozhong Kong, Xianrui Dou, Di Wang, Shuting Huang, Cong Yang, Dehui Liu, Guangqing Zhang, Jun Ai
Background Few reports have focused on the association between apparent treatment-resistant hypertension (aTRH) and cardiovascular (CV) mortality in peritoneal dialysis (PD) population, thus we conducted this retrospective cohort to explore it. Patients and Methods: This was a retrospective cohort study conducted from January 2011 to January 2020 with PD patients in 4 Chinese dialysis centers. ATRH
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Carotid Intima Media Thickness and Improved Stroke Risk Assessment in Hypertensive Black Adults Am. J. Hypertens. (IF 3.2) Pub Date : 2024-01-18 Temidayo A Abe, Titilope Olanipekun, Fengxia Yan, Valery Effoe, Ndausung Udongwo, Adebamike Oshunbade, Victoria Thomas, Ifeoma Onuorah, James G Terry, Wondwosen K Yimer, Jalal K Ghali, Adolfo Correa, Anekwe Onwuanyi, Erin D Michos, Emelia J Benjamin, Melvin Echols
Background We aim to determine the added value of carotid intima-media thickness (cIMT) in stroke risk assessment for hypertensive Black adults. Methods We examined 1647 participants with hypertension without a history of cardiovascular disease, from the Jackson Heart Study. Cox regression analysis estimated hazard ratios (HR) for incident stroke per standard deviation increase in cIMT and quartiles
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An Age Study on Adopting Adult Hypertension Standards in Chinese Mature Children and Adolescents Am. J. Hypertens. (IF 3.2) Pub Date : 2024-01-16 Xi Wang, Liwang Gao, Xia Wang, Jie Mi
OBJECTIVE To determine age cutoff values for the use of adult hypertension diagnostic criteria in children and adolescents, and to evaluate the consistency and screening effect of the adult criteria with the sex-, age-, and height-specific blood pressure reference (gold standard). METHODS A literature review and expert consultation were used to determine age cutoff value. In children above the cutoff
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Blood Pressure Measurements Obtained by Community-Dwelling Adults Are Similar to Nurse-Obtained Measurements: The SMART-BP Validate Study Am. J. Hypertens. (IF 3.2) Pub Date : 2024-01-14 Xiaoyue Liu, Sarah E Slone, Yuling Chen, Yvette Yeboah-Korieh, Abeer Alharthi, Johnitta Amihere, Sharon Moyo-Songonuga, Tynetta Lane, Yechiam Ostchega, Tammy M Brady, Cheryl R Himmelfarb, Yvonne Commodore-Mensah
Introduction Self-measured blood pressure (SMBP) is an effective strategy for managing and controlling hypertension. However, uncertainty regarding patients’ ability to accurately measure their blood pressure (BP) contributes to treatment inertia. Therefore, we compared BP measurements with the Omron HEM-9210T device obtained by nurses and community-dwelling adults after training. Methods This cross-sectional
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The Pathogenesis and Impact of Arterial Stiffening in Hypertension The 2023 John H. Laragh Research Award Am. J. Hypertens. (IF 3.2) Pub Date : 2024-01-11 Jing Liu, Jing Wu
Fifty years ago, Dr. John Laragh brought forward the “vasoconstriction-volume hypothesis” of hypertension. This is Ohm’s Law in blood pressure regulation, explicating hypertension as a consequence of increased peripheral vascular resistance, cardiac output, or both. Resistance vessels, those of a diameter less than 200 μm, determines mean arterial pressure by controlling peripheral vascular resistance
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Hypertension and mild cognitive impairment: state-of-the-art review Am. J. Hypertens. (IF 3.2) Pub Date : 2024-01-10 Sultana Shajahan, Ruth Peters, Cheryl Carcel, Mark Woodward, Katie Harris, Craig S Anderson
BACKGROUND Mid-life hypertension is associated with cognitive decline and dementia in later life. Reducing high blood pressure (BP) with antihypertensive agents is a well-researched strategy to prevent dementia and mild cognitive impairment (MCI). However, there is still limited direct evidence to support the approach, and particularly for the treatment of the very old and those with existing MCI.
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An intersectoral approach to hypertension care: Solutions for improving blood pressure control in São Paulo, Brazil Am. J. Hypertens. (IF 3.2) Pub Date : 2024-01-10 Álvaro Avezum, Luciano F Drager, Theresa Reiker, Alessandro Bigoni, Lays P Leonel, Ariane Abreu, Luiz Bortolotto, Marta Sólveig Palmeirim, Mariana Silveira, Beatriz Aquino, Rafael Venijio Maggion, Yara Carnevalli Baxter, Daniel Cobos Muñoz, Karina Mauro Dib, Amaury Zatorre Amaral, Jasmina Saric, Caitlin Jarrett, Johannes Boch
Summary Background Hypertension is the leading risk factor for cardiovascular diseases (CVDs) and a major public health issue worldwide. In Brazil, it affects approximately 52.5% of the adult population. We describe the solutions package and the impact of a population health initiative in São Paulo city, following the CARDIO4Cities approach for the management of cardiovascular risk. Methods Using a
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Comparison of Home and Office Blood Pressure Devices in the Clinical Setting Am. J. Hypertens. (IF 3.2) Pub Date : 2023-12-27 Stephen P Juraschek, Medha Vyavahare, Jennifer L Cluett, Ruth-Alma Turkson-Ocran, Kenneth J Mukamal, Anthony M Ishak
Background Self-measured blood pressure (SMBP) monitoring is increasingly used for remote hypertension management, but the real-world performance of home blood pressure (BP) devices is unknown. We examined BP measurements from patients’ home devices using the American Medical Association’s (AMA) Self-Measured Blood Pressure (SMBP) Device Accuracy Test tool. Methods Patients at a single internal medicine
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DO WE NEED NEW ELECTROCARDIOGRAPHIC CRITERIA FOR LEFT VENTRICULAR HYPERTROPHY? THE CASE OF THE PEGUERO LO PRESTI CRITERION. A NARRATIVE REVIEW Am. J. Hypertens. (IF 3.2) Pub Date : 2023-12-19 Andrea Faggiano, Elisa Gherbesi, Marijana Tadic, Stefano Carugo, Guido Grassi, Cesare Cuspidi
The cardiovascular risk associated with LVH in the community and, particularly, in the hypertensive fraction of the general population, represents the rationale for its timely and accurate identification in order to implement adequate preventive strategies. Although electrocardiography (ECG) is the first-line and most economical method of diagnosing LVH its accuracy is largely suboptimal. Over the
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Medical Measures in Hypertensives Considered Resistant Am. J. Hypertens. (IF 3.2) Pub Date : 2023-12-16 Fadl Elmula M Fadl Elmula, Julian Eek Mariampillai, Sondre Heimark, Sverre E Kjeldsen, Michel Burnier
BACKGROUND Patients with resistant hypertension is the group of hypertensive patients with the highest cardiovascular risk. METHODS All rules and guidelines for treatment of hypertension should be followed strictly to obtain blood pressure control in resistant hypertension. The mainstay of treatment of hypertension, also for resistant hypertension, is pharmacological treatment, which should be tailored
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Contributing Factors for the Increased Inter-arm Systolic Blood Pressure Difference in Different Age Groups Am. J. Hypertens. (IF 3.2) Pub Date : 2023-12-16 Ying Zhu, Qhuan Cao, Wenli Dong, Qi Tian, Ruiwa Mu, Di Qin, Xinlei Zhang, Hui Yang, Shouling Wu
OBJECTIVE To explore the contributing factors for the increased inter-arm systolic blood pressure difference (IASBPD) in young, middle-aged, and elderly people. METHODS A total of 51,428 workers in Kailuan who underwent arteriosclerosis detection of extremities during physical examination from 2010 to 2020 were selected as the subjects. The subjects were divided into 3 groups according to the age segment
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Prognostic Significance of Blood Pressure at Rest and after Performing the Six-Minute Walk Test in Patients with Acute Heart Failure Am. J. Hypertens. (IF 3.2) Pub Date : 2023-12-02 Jiale Huang, Zhongping Yu, Yuzhong Wu, Xin He, Jingjing Zhao, Jiangui He, Jan A Staessen, Yugang Dong, Chen Liu, Fang-Fei Wei
BACKGROUND It remains unclear whether systolic (SBP) and diastolic (DBP) pressure and BP response after 6-minute walk test (6MWT) are associated with adverse outcomes in patients with acute heart failure (AHF). METHODS We investigated these associations in 98 AHF patients (24.5% women; mean age, 70.5 years) enrolled in the ROSE trial (The Low-dose Dopamine or Low-dose Nesiritide in Acute Heart Failure
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Blood pressure variability and left ventricular diastolic dysfunction. Am. J. Hypertens. (IF 3.2) Pub Date : 2023-11-23 Yi-Lin Chen,Ji-Guang Wang
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The relevance of arterial blood pressure in the management of glaucoma progression: a systematic review Am. J. Hypertens. (IF 3.2) Pub Date : 2023-11-23 Jan Van Eijgen, Jesus D Melgarejo, Jana Van Laeken, Claire Van Der Pluijm, Hanne Matheussen, Micheline Verhaegen, Karel Van Keer, Gladys E Maestre, Lama A Al-Aswad, Thomas Vanassche, Zhen-Yu Zhang, Ingeborg Stalmans
Background Glaucoma is one of the leading causes of global blindness and is expected to co-occur more frequently with vascular morbidities in the upcoming years, as both are aging-related diseases. Yet, the pathogenesis of glaucoma is not entirely elucidated and the interplay between intraocular pressure, arterial blood pressure and ocular perfusion pressure is poorly understood. Objective This systematic
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Age and comorbidities are associated with therapeutic inertia among older adults with uncontrolled blood pressure Am. J. Hypertens. (IF 3.2) Pub Date : 2023-11-22 Grant T Hiura, Talar W Markossian, Beatrice D Probst, Mohammad Samie Tootooni, Gregory Wozniak, Michael Rakotz, Holly J Kramer
Background Lack of initiation or escalation of blood pressure (BP) lowering medication when BP is uncontrolled, termed therapeutic inertia (TI), increases with age and may be influenced by comorbidities. Methods We examined the association of age and comorbidities with TI in 22,665 visits with a systolic BP ≥ 140 mmHg and/or diastolic BP ≥ 90 mmHg among 7,415 adults age ≥ 65 years receiving care in
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Lower socioeconomic status, psychological distress, and self-reported hypertension: A longitudinal moderated mediation analysis Am. J. Hypertens. (IF 3.2) Pub Date : 2023-11-22 Liying Zhang, Rhonda Dailey, Robert D Brook, Ijeoma Nnodim Opara, Xianchen Liu, Jason T Carbone, Phillip D Levy
Background Lower socioeconomic status (SES) has been associated with hypertension; however, the mediators and moderators of this association remain understudied. We examined the mediation effect of psychological distress on the link between lower SES and self-reported hypertension and the racial and sex moderation effects. Methods We analyzed the data collected from 2009 to 2019 among adults from the
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Correlates of Spontaneous Blood Pressure Reduction Following Severe Inpatient Hypertension Development Am. J. Hypertens. (IF 3.2) Pub Date : 2023-11-21 Kanika Garg, Mary Kate Staunton, Aldo J Peixoto, F Perry Wilson, Lama Ghazi
BACKGROUND Severe hypertension (sHTN) is prevalent in 10% of hospitalized patients and treatment guidelines are lacking. As such, patients who develop sHTN might unnecessarily receive antihypertensive medications which could lead to worse outcomes. Our goal was to investigate correlates of spontaneous blood pressure (BP) reduction to help guide future treatment decisions and avoid harm associated with
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Neutrophil Elastase Inhibition by Sivelestat (ONO-5046) Attenuates AngII-induced Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Mice Am. J. Hypertens. (IF 3.2) Pub Date : 2023-11-20 Yoshiko Hada, Haruhito A Uchida, Shugo Okamoto, Nozomu Otaka, Katsuyoshi Katayama, Venkateswaran Subramanian, Alan Daugherty, Jun Wada
BACKGROUND Abdominal aortic aneurysm (AAA) is an arterial disease characterized by dilatation of the aortic wall. It has been suggested that neutrophil counts and neutrophil elastase activity are associated with AAA. We investigated whether a neutrophil elastase (NE) inhibitor, sivelestat (Siv), had a protective effect against angiotensin II (AngII)-induced AAAs. METHODS Male apolipoprotein E-deficient
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Peripheral blood microRNA-21 as a predictive biomarker for heart failure with preserved ejection fraction in old hypertensives Am. J. Hypertens. (IF 3.2) Pub Date : 2023-11-17 Maria Marketou, Joanna Kontaraki, Evangelos Zacharis, Spyros Maragkoudakis, Kostantinos Fragkiadakis, Emmanouil Kampanieris, Anthoula Plevritaki, Eirini Savva, Onoufrios Malikidis, Gregory Chlouverakis, George Kochiadakis
BACKGROUND Heart failure with preserved ejection fraction (HFpEF) is a major health issue with high morbidity and mortality. The epidemiology and the factors that cause HFpEF have not been fully clarified, while accurate predictive biomarkers are lacking. Our aim was to determine whether levels of microRNA-21 (miR-21) in peripheral blood monocytes, which play a critical role in many pathophysiological
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Leveraging Electronic Health Records to Construct a Phenotype for Hypertension Surveillance in the United States. Am. J. Hypertens. (IF 3.2) Pub Date : 2023-11-15 Siran He,Soyoun Park,Elena Kuklina,Nicole L Therrien,Elizabeth A Lundeen,Hilary K Wall,Katrice Lampley,Lyudmyla Kompaniyets,Samantha L Pierce,Laurence Sperling,Sandra L Jackson
BACKGROUND Hypertension is an important risk factor for cardiovascular diseases. Electronic health records (EHRs) may augment chronic disease surveillance. We aimed to develop an electronic phenotype (e-phenotype) for hypertension surveillance. METHODS We included 11,031,368 eligible adults from the 2019 IQVIA Ambulatory Electronic Medical Records-US (AEMR-US) dataset. We identified hypertension using
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Role of Endothelial-to-Mesenchymal Transition in Kidney Injury Associated With Salt-Sensitive Hypertension. Am. J. Hypertens. (IF 3.2) Pub Date : 2023-11-15 Jerzy Bełtowski
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Diagnostic and Predictive Value of Brachial–Ankle Pulse Wave Velocity and Pulse Pressure Index for Coronary Heart Disease in Elderly Patients With Hypertension Am. J. Hypertens. (IF 3.2) Pub Date : 2023-11-15 Yue Liu, Yajuan An, Jiao Li, Peng Yuan, Xin Qi, Liping Wei, Hua Yang
OBJECTIVE To explore the diagnostic and predictive value of pulse pressure index (PPI) and brachial–ankle pulse wave velocity (baPWV) for coronary heart disease (CHD) in elderly patients with hypertension. METHODS A total of 307 elderly patients who had chest pain or chest distress and coronary angiography were enrolled. According to the Gensini score, patients with CHD (n = 260) were divided into
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Increased Blood Pressure Variability Over a 16-Year Period is Associated with Left Ventricular Diastolic Dysfunction in a Population-Based Cohort. Am. J. Hypertens. (IF 3.2) Pub Date : 2023-11-07 Jae-Hyeong Park,Soon-Ki Ahn,Goo-Yeong Cho,Ki-Chul Sung,Seung Ku Lee,Seong Hwan Kim,Chol Shin
BACKGROUND Left ventricular diastolic dysfunction(LVDD) is often associated with elevated blood pressure(BP). It is prevalent among hypertensive patients. Additionally, increased BP variability has been linked to LVDD. However, the precise connection between LVDD and BP variability within the general population remains unclear. Thus, this study aimed to evaluate this association in a general population
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Unmasking hypertension phenotypes after pregnancy: an exploration of stress and adverse pregnancy outcomes on the development of hypertension. Am. J. Hypertens. (IF 3.2) Pub Date : 2023-10-25 Katherine Anais Sadaniantz,Shantel Brissett,Deborah Nadler,Lara C Kovell
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Isolated Nocturnal Hypertension in People Living with HIV: do we need HIV-specific guidelines for hypertension diagnosis? Am. J. Hypertens. (IF 3.2) Pub Date : 2023-10-24 Ruth K Lucinde,Robert N Peck
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N-acetylcysteine alleviates phenylephrine-induced cardiomyocyte dysfunction via engaging PI3K/AKT signaling pathway Am. J. Hypertens. (IF 3.2) Pub Date : 2023-10-21 Sheng-ping Chao, Wen-Lin Cheng, Wenjuan Yi, Huan-Huan Cai, Keqiong Deng, Jian-Lei Cao, Ziyue Zeng, Hairong Wang, Xiaoyan Wu
Background Increased ROS and oxidative stress response lead to cardiomyocyte hypertrophy and apoptosis, which play crucial roles in the pathogenesis of heart failure. The purpose of current research was to explore the role of antioxidant N-acetylcysteine (NAC) on cardiomyocyte dysfunction and the underlying molecular mechanisms. Methods and Results Compared with control group without NAC treatment
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What Is the Relevance of Low Standing Blood Pressure? Am. J. Hypertens. (IF 3.2) Pub Date : 2023-10-13 Felix Buder,Felix Mahfoud,Michael Böhm,Bernhard Haring
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Correlation Between Monocyte to High-Density Lipoprotein Cholesterol Ratio, Blood Flow-Mediated Dilation, and Arteriosclerosis in Young and Middle-Aged Patients With Essential Hypertension Am. J. Hypertens. (IF 3.2) Pub Date : 2023-10-13 Lu Honghong, Xie Lijuan, Wang Qinghang, Zhou Bi-rong
OBJECTIVE To investigate the relationship between monocyte to high-density lipoprotein cholesterol ratio (MHR), flow-mediated dilation (FMD), and arteriosclerosis in young and middle-aged patients with essential hypertension (EH). METHODS A total of 188 young and middle-aged patients with EH admitted to the Department of Cardiovascular Medicine of the First Affiliated Hospital of Anhui Medical University
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The Awareness and Behavior Model of Fujian Dentists Toward Managing Hypertensive Patients Am. J. Hypertens. (IF 3.2) Pub Date : 2023-10-13 Lingling Huang, Bin Wei, Lei Bao, Liang Xu, Xiaofeng Zhu
BACKGROUND To evaluate the awareness and behavior model of dentists in managing and treating hypertensive patients in Fujian Province. METHODS E-questionnaires were created and sent to dentists of all levels in Fujian Province (n = 610). The questionnaire included an assessment of attitude and behavior toward using a sphygmomanometer in the department of stomatology or clinic, as well as an assessment
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Renin inhibition and the long-term renal function in patients with hypertensive emergency: a retrospective cohort study Am. J. Hypertens. (IF 3.2) Pub Date : 2023-10-11 Masaki Ueno, Wataru Fujii, Wataru Ono, Hiroshi Murata, Yoshihide Fujigaki, Shigeru Shibata
Background The rehospitalization rate in hypertensive emergency is high, indicating the necessity for optimizing its long-term management. The role of the renin-angiotensin system (RAS) blockade in this disorder remains uncertain. Methods We conducted a retrospective analysis involving 20 admitted patients who received aliskiren, a direct renin inhibitor (DRI), for the management of hypertensive emergency
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Factors Associated with Antihypertensive Therapy Prescription in Youth Delaware Medicaid Recipients with Primary Hypertension Diagnosis Am. J. Hypertens. (IF 3.2) Pub Date : 2023-10-10 Carissa M Baker-Smith, Mary J McDuffie, Erin P Nescott, Robert E Akins
Background Higher neighborhood deprivation is associated with hypertension diagnosis in youth. In this study, we assess if there is an association between neighborhood deprivation and anti-hypertensive therapy prescription among insured youth with a primary hypertension diagnosis. Methods Using a retrospective cross-sectional design, we assessed the proportion of youth with a diagnosis of primary hypertension
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Psychological distress and hypertension diagnostic testing: Is there anything to worry about? Am. J. Hypertens. (IF 3.2) Pub Date : 2023-10-05 Josefin Särnholm,Ian M Kronish
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Intraprocedural Cortisol Testing During Adrenal Vein Sampling for Primary Aldosteronism: Weighing the Benefits and Limitations. Am. J. Hypertens. (IF 3.2) Pub Date : 2023-10-04 Gregory L Hundemer
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Intraprocedural Cortisol Measurement Increases Adrenal Vein Cannulation Success Rate in Primary Aldosteronism: A Systematic Review and Meta-analysis Am. J. Hypertens. (IF 3.2) Pub Date : 2023-10-01 Yaqiong Zhou, Huamin Zhang, Jie Luo, Jixin Hou, Qiang Xue, Xiaohan Wang, Hui Guo, Xinquan Wang, Peijian Wang
Objective This study aimed to explore the effectiveness of intraprocedural cortisol measurement (IPCM) for the technical success rates of bilateral adrenal vein, right adrenal vein (RAV) and left adrenal vein (LAV) cannulation during adrenal vein sampling (AVS). Methods Systematic searches of PubMed, Embase, Cochrane Library and ClinicalTrials.gov were performed from database inception to May 10, 2023
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Isolated Nocturnal Hypertension in People Living with Human Immunodeficiency Virus (PWH): A Cross-Sectional Study Am. J. Hypertens. (IF 3.2) Pub Date : 2023-09-29 Matias G Zanuzzi, Silvina M López, Máximo J Cattaneo, María A Pérez-Maure, Cecile D Lahiri, Cesar A Romero
Background Nocturnal Hypertension (NH) is a potent cardiovascular risk factor described frequently in people with HIV (PWH). Isolated NH (INH) is less well reported in PWH because of the need for ambulatory blood pressure monitoring (ABPM) in office normotensive patients. We aim to document the prevalence of NH and INH and the clinical factors associated with these phenotypes. Methods Cross-sectional
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Rural and Urban Differences in Hypertension Management Through Telehealth Before and During the COVID-19 Pandemic Among Commercially Insured Patients Am. J. Hypertens. (IF 3.2) Pub Date : 2023-09-29 Jun Soo Lee, Ami Bhatt, Sandra L Jackson, Lisa M Pollack, Nina Omeaku, Kincaid Lowe, Cidney Wilson, Feijun Luo, Kakoli Roy
Background The COVID-19 pandemic prompted a rapid increase in telehealth use. However, limited evidence exists on how rural and urban residents used telehealth and in-person outpatient services to manage hypertension during the pandemic. Methods This longitudinal study analyzed 701,410 US adults (18–64 years) in the MarketScan Commercial Claims Database, who were continuously enrolled from January
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Alcohol consumption and antihypertensive treatment effect in male patients with hypertension Am. J. Hypertens. (IF 3.2) Pub Date : 2023-09-28 Xiao-Fei Ye, Wen-Yuan-Yue Wang, Xin-Yu Wang, Qi-Fang Huang, Yan Li, Ji-Guang Wang
BACKGROUND Alcohol consumption is a proven risk factor of hypertension. In the present analysis, we investigated the use of antihypertensive medications and blood pressure control in male alcohol drinkers and non-drinkers with hypertension (systolic/diastolic blood pressure 160-199/100-119 mm Hg). METHODS The study participants were patients enrolled in a 12-week therapeutic study and treated with
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Towards a more widespread clinical use of cardio-ankle vascular index (CAVI) and CAVI0:Defining reference values in healthy Russians. Am. J. Hypertens. (IF 3.2) Pub Date : 2023-09-27 Bart Spronck,Alessandro Giudici
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Potassium and Hypertension: A State-of-the-Art Review Am. J. Hypertens. (IF 3.2) Pub Date : 2023-09-27 Sriram Sriperumbuduri, Paul Welling, Marcel Ruzicka, Gregory L Hundemer, Swapnil Hiremath
Hypertension is the single most important and modifiable risk factor for cardiovascular morbidity and mortality worldwide. Non pharmacologic interventions, in particular dietary modifications have been established to decrease blood pressure and hypertension related adverse cardiovascular events. Among those dietary modifications, sodium intake restriction dominates guidelines from professional organizations
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Association of pulse pressure fluctuation during hospitalization with adverse outcomes within 3 months after ischemic stroke Am. J. Hypertens. (IF 3.2) Pub Date : 2023-09-27 Yu Wang, Jintao Zhang, Zhengbao Zhu, Yanbo Peng, Yang Liu, Ruirui Wang, Mengyao Shi, Aili Wang, Tian Xu, Hao Peng, Tan Xu, Jing Chen, Yonghong Zhang, Jiang He
Background Pulse pressure (PP) depends on heart function and arterial wall elasticity, which is closely related to the incidence of ischemic stroke. However, the association of PP fluctuation during hospitalization with adverse outcomes after ischemic stroke remains unclear. Methods The present study included 3971 patients with ischemic stroke. The primary outcome was the composite outcome of death
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Neighborhood Deprivation, Perceived Stress, and Pregnancy-Related Hypertension Phenotypes a Decade Following Pregnancy Am. J. Hypertens. (IF 3.2) Pub Date : 2023-09-25 Jewel Scott, Alisse Hauspurg, Matthew F Muldoon, Esa M Davis, Janet M Catov
Background Hypertensive disorders in pregnancy and other adverse pregnancy outcomes increase the risk of developing chronic hypertension and cardiovascular disease. Perceptions of stress and neighborhood context also influence BP fluctuations. We examined if adverse pregnancy outcomes, higher perceived stress, and neighborhood deprivation were associated with hypertension phenotypes a decade after
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Circ_0068481 affects the human pulmonary artery smooth muscle cells' progression by miR-361-3p/KLF5 axis. Am. J. Hypertens. (IF 3.2) Pub Date : 2023-09-20 Hai-Rong Li,Guan-Liang Chen,Xiao-Li Fang,Xing-Jiu Cai,Rong-Li Xu,Dong-Dong Li,Zhi-Wei Zhang
BACKGROUND Uncontrolled proliferation of pulmonary artery smooth muscle cells (PASMCs) contributes to the pathogenesis of pulmonary arterial hypertension (PAH). In this work, we defined the precise part of circ_0068481 in PASMC proliferation and migration induced by hypoxia. We hypothesized that circ_0068481 enhanced hypoxia-induced PASMC proliferation, invasion and migration through the miR-361-3p/KLF5
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Pulse Check - Arterial Health after Preeclampsia. Am. J. Hypertens. (IF 3.2) Pub Date : 2023-09-20 Mohammad A Salameh,Andrea G Kattah
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Beyond Individual Risk Factors in Atrial Fibrillation: The Interactions of Hypertension and Sex. Am. J. Hypertens. (IF 3.2) Pub Date : 2023-09-15 Eduard Shantsila,Alena Shantsila,Gregory Y H Lip
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Characteristics and Predictors of Apparent Treatment Resistant Hypertension in Real-World Populations Using Electronic Health Record-Based Data Am. J. Hypertens. (IF 3.2) Pub Date : 2023-09-12 Eissa Jafari, Rhonda M Cooper-DeHoff, Mark B Effron, William R Hogan, Caitrin W McDonough
BACKGROUND Apparent treatment-resistant hypertension (aTRH) is defined as uncontrolled blood pressure (BP) despite using ≥3 antihypertensive classes or controlled BP while using ≥4 antihypertensive classes. Patients with aTRH have a higher risk for adverse cardiovascular outcomes compared to patients with controlled hypertension (HTN). Although there have been prior reports on the prevalence, characteristics
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Model-based assessment of the reference values of CAVI in healthy Russian population and benchmarking with CAVI0. Am. J. Hypertens. (IF 3.2) Pub Date : 2023-09-11 Tatiana Safronova,Anna Kravtsova,Sergei Vavilov,Cristina Leon,Anna Bragina,Victor Milyagin,Ruslan Makiev,Alexei Sumin,Kirill Peskov,Victor Sokolov,Valery Podzolkov
BACKGROUND Cardio-ankle vascular index (CAVI) and its modified version (CAVI0) are promising non-invasive markers of arterial stiffness, extensively evaluated primarily in the Japanese population. In this work, we performed a model-based analysis of the association between different population characteristics and CAVI or CAVI0 values in healthy Russian subjects and propose a tool for calculating the
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Is Hypertension Diagnostic Testing and Diagnosis Associated with Psychological Distress? Am. J. Hypertens. (IF 3.2) Pub Date : 2023-09-09 B B Green, M L Anderson, J B McClure, K Ehrlich, Y N Hall, L Hansell, C Hsu, K L Margolis, S A Munson, M J Thompson
Background Psychological impacts of hypertension diagnostic testing and new hypertension diagnoses are unclear. Methods BP-CHECK was a randomized diagnostic study conducted in 2017-2019 in an integrated healthcare system. Participants with no hypertension diagnosis or medications and elevated blood pressure (BP) were randomized to one of three diagnostic regimens: (1) Clinic, (2) Home, or (3) Kiosk