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Role of Angiopoietin/Tie2 System in Sepsis: A Potential Therapeutic Target Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-03-07 Yawen Chi, Sihan Yu, Jia Yin, Danyan Liu, Mengke Zhuo, Xu Li
Sepsis is a disorder of host response caused by severe infection that can lead to life-threatening organ dysfunction. There is no specific treatment for sepsis. Although there are many different pathogens that can cause sepsis, endothelial dysfunction is a frequent mechanism resulting in vascular leakage and coagulation problem. Recent studies on the regulatory pathways of vascular endothelium have
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Triglyceride-glucose Index as a Valuable Marker to Predict Severity of Coronary Artery Disease: A Retrospective Cohort Study Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-03-06 Xu Geng, Xi Zhang, XiaoWei Li, ChunTing Zhong, Min Hou
Background and AimsThe diagnostic standard of coronary artery disease (CAD) is coronary angiography (CAG). Since CAG is an invasive procedure underscores the need for identifying non-invasive, effective, and innovative biomarkers. Our study aimed to retrospectively analyze hematological markers for predicting the severity of CAD.Methods and ResultsCase data were collected from 195 CAD patients admitted
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Platelet Function Testing to Guide Cangrelor Dosing in Patients with Temporary Mechanical Circulatory Support or as a Bridge to Procedure Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-03-05 Margaret M. Buck, Chelsea I. Barry, Courtney A. Montepara, Nathan J. Verlinden
Cangrelor is a rapid-acting, intravenous P2Y12 inhibitor that can be used in patients after percutaneous coronary intervention who require mechanical circulatory support or as a bridge to procedure. We retrospectively reviewed adult patients who received platelet function testing (PFT) with the VerifyNow P2Y12 assay while on cangrelor from March 2021 through November 2022. All patients were initiated
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Super Formula for Soluble C-Type Lectin-Like Receptor 2 × D-Dimer in Patients With Acute Cerebral Infarction Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-02-26 Toshitaka Kamon, Hideo Wada, Shotaro Horie, Tomoya Inaba, Karin Okamoto, Katsuya Shiraki, Yuhuko Ichikawa, Minoru Ezaki, Motomu Shimaoka, Akisato Nishigaki, Akihiro Shindo, Hideto Shimpo, Nobuo Ito
Acute cerebral infarction (ACI) includes atherosclerotic and cardiogenic ACI and involves a thrombotic state, requiring antithrombotic treatment. However, the thrombotic state in ACI cannot be evaluated using routine hemostatic examinations. Plasma soluble C-type lectin-like receptor 2 (sCLEC-2) and D-dimer levels were measured in patients with ACI. Plasma sCLEC-2 and D-dimer levels were significantly
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A Novel Nomogram for Predicting Warfarin-Related Bleeding: A Retrospective Cohort Study Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-02-23 Shaohua Yang, Wensen Yao
Warfarin is a widely used anticoagulant, and bleeding complications are the main reason why patients discontinue the drug. Currently, there is no nomogram model for warfarin-associated bleeding risk. The aim of this study was to develop a risk-prediction nomogram model for warfarin-related major and clinically relevant non-major (CRNM) bleeding. A total of 280 heart disease outpatients taking warfarin
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Immature Platelet Fraction and Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-02-20 Lee Oppenheim, Ranel Loutati, David Marmor, Nimrod Perel, Meir Tabi, Louay Taha, Danny Dvir, Mony Shuvy, Rami Jubeh, Michael Glikson, Elad Asher
IntroductionImmature platelets or reticulated platelets are newly released thrombocytes. They can be identified by their large size and high RNA cytoplasm concentration. Immature platelet fraction (IPF) represents the percentage of immature circulative platelets relative to the total number of platelets. The role of IPF in patients undergoing transcatheter aortic valve implantation (TAVI) is unknown
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Development and Validation of a Nomogram for Predicting the Severity of Coronary Artery Disease Based on Cardiopulmonary Exercise Testing Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-02-20 Hongmin Wang, Yi Wang, Qingmin Wei, Liyan Zhao, Qingjuan Zhang
As a major global health concern, coronary artery disease (CAD) demands precise, noninvasive diagnostic methods like cardiopulmonary exercise testing (CPET) for effective assessment and management, balancing the need for accurate disease severity evaluation with improved treatment decision-making. Our objective was to develop and validate a nomogram based on CPET parameters for noninvasively predicting
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Evaluation of Hemogram Parameters in the Diagnosis of Pulmonary Embolism: Immature Granulocytes and Other New Tips Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-02-13 Gokhan Karakurt, Oya Guven, Engin Aynaci, Bugra Kerget, Gizem Senkardesler, Mustafa Duger
Pulmonary embolism (PE) is an important cause of sudden death and is difficult to diagnose. Therefore unnecessary radiological investigations are often resorted to. Although some inflammatory parameters in the hemogram have been found to play a role in the diagnosis of PE, many parameters have not been adequately investigated. We aimed to evaluate potential inflammatory parameters in hemogram in the
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Investigating the Impact on Long-Term Outcomes and the Necessity of Hereditary Thrombophilia Screening in Presumed or Perinatal Arterial Ischemic Stroke Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-02-08 Ömer Bektaş, Özben Akıncı Göktaş, Begüm Atasay, Serap Teber
This study aimed to investigate the influence of prothrombotic risk factors on long-term outcomes of patients with perinatal arterial ischemic stroke. The study was conducted through an analysis of monitoring results that were regularly maintained for approximately 20 years at a tertiary stroke-monitoring center. The study assessed prothrombotic risk factors, radiological area of involvement, clinical
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Coagulation Testing in Real-World Setting: Insights From a Comprehensive Survey Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-02-07 Hae In Bang, Ja Young Lee, Hyun-Young Kim, Saeam Shin, Myung Hyun Nam, In-Suk Kim, Ji Myung Kim, Jong-Hyun Yoon, Myung-Geun Shin, Sang Mee Hwang, Sun-Young Kong
The objective of this survey was to gain a real-world perspective on coagulation testing by evaluating the availability of various coagulation laboratory tests, assessing specific analytic and postanalytic steps in clinical laboratories in Korea.Participants were surveyed using a 65-question questionnaire specifically focused on their coagulation testing practices related to prothrombin time (PT),
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The Role of HATCH Score in the Prediction of Ischemic Cerebrovascular Events in Patients with Heart Failure and Atrial Fibrillation Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-01-19 Sidar Şiyar Aydın, Emrah Aksakal
The presence of both atrial fibrillation (AF) and heart failure (HF) increases the risk of an ischemic cerebrovascular event (CVE) by roughly fivefold. The HATCH score is a score used to predict new-onset AF. Although there are some differences, it contains risk factors similar to the CHA2DS2-VASc score. Our study aimed to investigate the relationship between the HATCH score and ischemic CVE. This
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Determination of vWF, ADAMTS-13 and Thrombospondin-1 in Venous Thromboembolism and Relating Them to the Presence of Factor V Leiden Mutation Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-01-16 Anwar Al-Awadhi, Rajaa Marouf, Mehrez M. Jadaon, Mohammad M. Al-Awadhy
Thrombophilia in venous thromboembolism (VTE) is multifactorial. Von Willebrand factor (vWF) plays a major role in primary hemostasis. While elevated vWF levels are well documented in VTE, findings related to its cleaving protease (ADAMTS-13) are contradicting. The aim of this study was to determine vWF, ADAMTS-13, and the multifactorial Thrombospondin-1 (TSP-1) protein levels in patients after 3-6
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Clinical Outcomes at 3 Years After Stenting for Thrombotic and Non-thrombotic Iliac Vein Compression Syndrome Patients Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-01-12 Lei Jiang, Hao Zhuang, Tao Song, Xiao-Qiang Li
Iliac vein stenting for the treatment of iliac vein compression syndrome (IVCS) has been gradually developed. This article investigated the long-term patency and improvement of clinical symptoms after endovascular stenting for iliac vein obstruction patients. From 2020 to 2022, 83 patients at a single institution with IVCS underwent venous stent implantation and were divided into two groups: non-thrombotic
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Cardiac Arrest-Associated Coagulopathy Could Predict 30-day Mortality: A Retrospective Study from Medical Information Mart for Intensive Care IV Database Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-01-10 Jingwei Duan, Hongxia Ge, Wenyang Fan, Lanfang Du, Hua Zhang, Ayijiang Jiamaliding, Baomin Duan, Qingbian Ma
BackgroundCardiac arrest (CA) can activate the coagulation system. Some coagulation-related indicators are associated with clinical outcomes. Early evaluation of patients with cardiac arrest-associated coagulopathy (CAAC) not only predicts clinical outcomes, but also allows for timely clinical intervention to prevent disseminated intravascular coagulation.ObjectiveTo assess whether CAAC predicts 30-day
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Thrombotic Risk and Calculated Whole Blood Viscosity in a Cohort of Patients With New Diagnosis of Multiple Myeloma Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-01-04 Melania Carlisi, Rosalia Lo Presti, Salvatrice Mancuso, Sergio Siragusa, Gregorio Caimi
The pathogenesis of venous thromboembolism in multiple myeloma is still poorly understood because multiple factors are involved. In particular, the increase in whole blood viscosity has a key role and, therefore, we performed an evaluation of some hemorheological determinants in multiple myeloma patients, putting them in relation to the thrombotic risk, with the aim to evaluate if an alteration of
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Treatment Patterns and Healthcare Resource Utilization of Patients With Paroxysmal Nocturnal Hemoglobinuria: A Retrospective Claims Data Analysis Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-01-04 Denise Clayton, Jason Shafrin, Glorian Yen, Soyon Lee, Lincy Geevarghese, Yulin Shi, Luyang He, Ying Shen, Anem Waheed
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired hematologic disorder commonly treated with complement inhibitors such as eculizumab, ravulizumab, and pegcetacoplan. This study aims to describe treatment patterns, healthcare resource utilization, and cost for newly diagnosed PNH patients in 2 large, health insurance claims databases: MarketScan and Optum. Among the 271 patients meeting
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Predictive Value of Pulmonary Artery Distensibility for Short-Term Adverse Clinical Outcomes in Patients with Acute Pulmonary Embolism Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-01-03 Fei Yang, Rong Chen, Yue Yang, Yaxi Yu, Zhixiang Yang, Dianjun Zou, Zhiying Pang, Dawei Wang
We aimed to explore the relationship between pulmonary artery distensibility obtained from computed tomography pulmonary angiography (CTPA) and short-term adverse clinical outcomes in patients with acute pulmonary embolism (APE). We included patients who underwent retrospective electrocardiogram-gated CTPA and were subsequently diagnosed with APE. Patients were categorized into good and poor outcome
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Emicizumab Prophylaxis in Patients with Severe Hemophilia A: Insights from A Resource Limited Country Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-01-03 Munira Borhany, Aisha Arshad, Heeba Qureshi, Rukhshanda Nadeem, Arif Jamal, Raheel Ahmed Khan
Emicizumab is a humanized, bispecific monoclonal antibody that connects active factor IX and X to replace the function of absent factor VIII, restoring hemostasis. It has a long half-life with a subcutaneous route of administration and high bioavailability. Here, we assessed the efficacy of Emicizumab prophylaxis in terms of efficiency, safety, and quality of life of severe hemophilia A (HA) patients
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Efficacy and Safety of a Pharmaco-Invasive Strategy Using Half-Dose Recombinant Human Prourokinase in Patients with ST-Segment Elevation Myocardial Infarction During Hospitalization Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-01-03 Jie Dou, Jie Gao, Huihui Yang, Ruoling Guo, Chao Jiang, Jingtao Guo, Donglei Luo
This study investigated the efficacy and safety of pharmaco-invasive strategy with half-dose recombinant human prourokinase (PHDP) during hospitalization for patients with ST-segment elevation myocardial infarction (STEMI) to provide references for the treatment of STEMI. Patients with STEMI who fulfilled the inclusion and exclusion criteria and attended Chengde Central Hospital, Hebei Province, China
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Predictive Role of Pre-Thrombolytic Neutrophil-Platelet Ratio on Hemorrhagic Transformation After Intravenous Thrombolysis in Acute Ischemic Stroke Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2024-01-03 Xu-Dong Cheng, Chun-Xi Zhang, Qi Zhang, Sen Zhou, Li-Jun Jia, Li-Rong Wang, Jian-Hong Wang, Neng-Wei Yu, Bing-Hu Li
To investigate the predictive role of the neutrophil-platelet ratio (NPR) before intravenous thrombolysis (IVT) on hemorrhagic transformation (HT) in patients with acute ischemic stroke (AIS). AIS patients treated with IVT without endovascular therapy between June 2019 and February 2023 were included. Patients were divided into high NPR (>35) and low NPR (≤35) groups according to the optimal threshold
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Evaluating the Association Between Fibrinogen and Rotational Thromboelastometry and the Progression to Severe Obstetric Hemorrhage Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-05-15 Mary Yurashevich, Morgan Rosser, Maria Small, Chad Grotegut, Nancy Kota, John Toffaletti, Terrence Allen
AimThis study aims to investigate the ability of fibrinogen and rotational thromboelastometry (ROTEM) parameters measured at obstetric hemorrhage protocol initiation to predict severe hemorrhage.Me...
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Regional Citrate Anticoagulation or Heparin Anticoagulation for Renal Replacement Therapy in Patients With Liver Failure: A Systematic Review and Meta-Analysis Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-05-15 Wenqian Qi, Jingyuan Liu, Ang Li
In patients with liver failure complicated by acute kidney injury, renal replacement therapy (RRT) is often required to improve the internal environment. The use of anticoagulants for RRT in patien...
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Blended Heparin: A new Perspective to Guarantee the Supply of a Life-Saving Drug? Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-05-11 Marco Guerrini
The risk of heparin shortage opens up the possibility of diversifying the sources of heparin by introducing products of other animal/organ origins. In addition to bovine heparin, already used in th...
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Factors Affecting Recanalization in Femoropopliteal Deep Vein Thrombosis Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-05-10 Mehmet Emir Erol, Sertan Özyalçın, Kudret Atakan Tekin, Adem İlkay Diken, Adnan Yalçınkaya, Ertekin Utku Ünal
Effects of warfarin and new-generation direct oral anticoagulants (DOACs) on thrombus resolution after the treatment of deep vein thrombosis (DVT) are still unknown. The study aimed to investigate ...
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Association Between Inferior Vena Cava-Involved Thrombosis, Severe Iliac Vein Stenosis, and Proximal Pulmonary Embolism in Patients With Deep Vein Thrombosis Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-05-04 Maofeng Gong, Yadong Shi, Jie Kong, Boxiang Zhao, Zhengli Liu, Xu He, Jianping Gu
To investigate the possible risk factors for proximal pulmonary embolism (PE) in patients with lower extremity deep vein thrombosis (LEDVT). A single-center, retrospective cohort study was conducte...
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Assessment of Anticoagulant Initiation in Patients With New-Onset Atrial Fibrillation During Emergency Department Visit—Point-by-Point Response Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-05-03 Ehsan Habeeb, Themio Papadopoulos, Andrea R. Lewin, Danielle Knowles
Patients with atrial fibrillation (AF) have an increased risk of stroke and systemic thromboembolism. Diagnosis of AF is commonly encountered in the emergency department (ED). The purpose of this s...
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Lack of Consensus in Rehabilitation Protocols After Posterior Shoulder Stabilization Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-05-04 Sydney Dacey, Ozair Meghani, James H. Dove, Nicholas J. Lemme, Rory A. Byrne, Brett D. Owens
Background:Posterior shoulder instability is being identified and treated more frequently by orthopaedic providers. After posterior shoulder stabilization, long-term outcomes in function and mobili...
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Return to Preinjury-Level Sports After Arthroscopic Latarjet for Recurrent Anterior Shoulder Instability in Professional Athletes Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-05-04 Roman Brzoska, Hubert Laprus, Shahbaz S. Malik, Wojciech Solecki, Barlomiej Juszczak, Adrian Blasiak
Background:The Latarjet procedure is recommended to treat recurrent anterior shoulder instability with glenoid bone loss. Longer return-to-sport (RTS) times have been reported after the open Latarj...
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Return to Play and Performance After Anterior Cruciate Ligament Reconstruction in the National Women’s Soccer League Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-05-04 Varag Abed, Ajith Dupati, Gregory S. Hawk, Darren Johnson, Caitlin Conley, Austin V. Stone
Background:The anterior cruciate ligament (ACL) is commonly injured in elite-level female athletes, which usually requires ACL reconstruction (ACLR).Purpose:To analyze return to play (RTP) and chan...
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Posterior Approach to the Popliteal to Peroneal Bypass Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-05-04 Sigrid L Williamson, Bernice Yu, Robert Luo
Critical limb ischemia (CLI) is a clinical syndrome related to peripheral artery disease (PAD) that is marked by ischemic rest pain or tissue loss such as nonhealing ulcers or gangrene. Without rev...
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Interrelationships between cotton fiber quality traits and tensile properties of hydroentangled nonwoven fabrics Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-05-04 Doug J Hinchliffe, Gregory N Thyssen, Brian D Condon, Linghe Zeng, Rebecca J Hron, Crista A Madison, Johnie N Jenkins, Jack C McCarty, Christopher D Delhom, Ruixiu Sui
Cotton fibers can be used to produce nonwovens suitable for numerous single use applications including hygiene, wipes, and medical products among others. Cotton comprises a relatively small amount ...
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Efficacy and Safety of Direct Oral Anticoagulants Compared With Heparin for Preventing Thromboembolism in Hospitalized Patients With COVID-19: A Systematic Review and Meta-Analysis Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-05-02 Yong Tian, Tao Pan, Xudong Wen, Guangyu Ao, Yihan Ma, Xiaoxiao Liu, Rui Liu, Hongmei Ran
A high rate of thromboembolism and a high risk of death have been reported regarding hospitalized patients with coronavirus disease 2019 (COVID-19). Recently, we noticed that clinicians in some com...
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Machine Learning to Dynamically Predict In-Hospital Venous Thromboembolism After Inguinal Hernia Surgery: Results From the CHAT-1 Study Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-04-24 Yi–Dan Yan, Ze Yu, Lan-Ping Ding, Min Zhou, Chi Zhang, Mang-Mang Pan, Jin-Yuan Zhang, Ze-Yuan Wang, Fei Gao, Hang-Yu Li, Guang-Yong Zhang, Hou-Wen Lin, Ming-Gang Wang, Zhi–Chun Gu
BackgroundThe accuracy of current prediction tools for venous thromboembolism (VTE) events following hernia surgery remains insufficient for individualized patient management strategies. To address...
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Impact of Vitamin K Administration on Elevated International Normalized Ratio in Chronic Liver Disease Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-04-24 Carmen B. Smith, Erin K. Hennessey, Caroline D. Crossey, Andrew J. Crannage
Limited studies assess the efficacy of vitamin K administration in patients with chronic liver disease (CLD). However, vitamin K is commonly used to treat elevations in international normalized rat...
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Low MHR Is Associated with Hemorrhagic Transformation in Acute Large Artery Atherosclerosis Ischemic Stroke Patients with Intravenous Thrombolysis Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-04-21 Delong Meng, Yan Li, Ting Ju, Wei Huo, Mingfei Wang
Background: Hemorrhagic transformation (HT) is a common complication of intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS) and may lead to neurological deterioration. This ...
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Standard-Intensity Versus Low-Intensity Anticoagulation with Warfarin in Asian Patients with Atrial Fibrillation: A Multi-Center, Randomized Controlled Trial Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-04-20 Jeong Gwan Cho, Ki Hong Lee, Yoo Ri Kim, Sunah Kim, Jisoo Gwak, Eunbit Cho, Yourim Sin, Seung Yong Shin, Hyung Wook Park, Jum Suk Ko, Nam Ho Kim, Yae Min Park, Jung Myung Lee, Nam Sik Yoon, Sung Soo Kim, Jun Hyung Kim, Dong Min Kim
Anticoagulation with warfarin in Asian patients with atrial fibrillation (AF) often has been decreased as an international normalized ratio (INR) of prothrombin time 1.6-2.6 due to fear of bleeding...
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Characteristics, Thrombus Resolution, and Long-Term Outcomes in Patients with Nonvalvular Atrial Fibrillation and Atrial Thrombus Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-04-20 Shu Yang, Yanjuan Zhang, Ning Chen, Jiaojiao Shi, Weizhu Ju, Hongwu Chen, Gang Yang, Zidun Wang, Hailei Liu, Xiaohong Jiang, Chang Cui, Minglong Chen, Mingfang Li
To assess the prevalence and management of atrial thrombus in patients with nonvalvular atrial fibrillation (NVAF) and identify the risk factors of the nonresolution of atrial thrombus. This single...
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Clinical Outcome of Deep Vein Thrombosis Is Related to Thrombophilic Risk Factors Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-04-17 Miriam Anna Simon, Christina Klaeffling, Josephine Ward, Steffen Rauchfuss, Wolfgang Miesbach
Deep vein thrombosis (DVT) and the associated possible complication of pulmonary artery embolism (LAE) represent a recognized reason for significant perioperative morbidity and mortality. There is ...
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Evaluation of Latex Immunoturbidimetric Assay Thresholds and HIT in Cardiothoracic Surgery Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-04-17 Jessica Hernandez, Hetal Patel, Phil Biddlecome, Megan Kildea, Ruti Dwivedi, Shashank Sridhara, Scott Silvestry, Nicholas Cavarocchi, John L. Francis, Davide Ventura
BackgroundHeparin-induced thrombocytopenia (HIT) is a common differential diagnosis in cardiothoracic surgery. The latex immunoturbidimetric assay (LIA) is an enhanced immunoassay that has recently...
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Profile of Solid Tumor Patients Complicated With Venous Thromboembolism: A 10-Year Retrospective Cross-Sectional Study Based on 1482 Cases Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-04-16 Huimin Li, Yu Tian, Haiwen Niu, Lili He, Guolei Cao, Changxi Zhang, Kaiseer Kaiweisierkezi, Qin Luo
The aim of this single-centre 10-year retrospective observational study was to evaluate the profile of Chinese cancerous patients complicated with venous thromboembolism (VTE) based on demographic ...
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The Relevance of Thrombo-Inflammatory Biomarkers and Their Relationship with Circulating Glycosaminoglycans in End-Stage Renal Disease Patients Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-04-16 Madeline Allen, Vinod Bansal, Fakiha Siddiqui, Debra Hoppensteadt, Emily Krupa, Jawed Fareed, Bulent Kantarcioglu
En-stage renal disease (ESRD) is a growing public health problem. The atherosclerotic cardiovascular complications are the leading causes of mortality and morbidity in the ESRD. In this study, we s...
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Mean Platelet Volume as a Predictor of Coronary Artery Disease Severity and its Association With Coronary Artery Calcification Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-31 Itshak Amsalem, Elad Asher, Inbar Blaufeld, Rafael Hitter, Nir Levi, Louay Taha, Fauzi Fadi Shaheen, Hani Karameh, Tomer Maller, Nimrod Perel, Yoed Steinmetz, Mohammad Karmi, Kamal Hamayel, Mohammed Manassra, Talya Wolak, Michael Glikson, Arik Wolak
Coronary calcium score (CCS) is a highly sensitive marker for estimating coronary artery calcification (CAC) and detecting coronary artery disease (CAD). Mean platelet volume (MPV (is a platelet in...
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Occurrence of FVIII Inhibitors in Hemophilia A Patients Following an Institutional Switch to a Third Generation B-Domain-Deleted FVIII Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-30 Louise H Hooimeijer, Marjet A Stein-Wit, Marja AJ Voskuilen, Michaël V Lukens, Karina Meijer, Anja BU Mäkelburg, Rienk YJ Tamminga
In 2018, Refacto AFR, a B-domain-deleted third-generation FVIII concentrate, became our preferential product. After the introduction, the development of inhibitors was prospectively monitored; retr...
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Incidence and Risk Factors of Admission Deep Vein Thrombosis in Patients With Traumatic Fracture: A Multicenter Retrospective Study * Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-30 Li Zhang, Xiaobing Liu, Peng Pang, Zhenguo Luo, Wenbo Cai, Wangyang Li, Jianhong Hao
To identify risk factors of admission deep vein thrombosis (DVT) in patients with traumatic fractures. Medical records of 1596 patients with traumatic fractures were reviewed. According to the ultr...
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Association Between Transforming Growth Factor-β1 Polymorphisms and Ischemic Stroke Susceptibility: A Meta-Analysis Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-30 Xiao-Qin Peng, Fan Cheng, Lan Zhou
Epidemiological studies have suggested a potential relationship between the transforming growth factor-β1 (TGF-β1) gene and ischemic stroke (IS) risk; however, the current results are inconsistent....
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The Impact of Patient Characteristics and Antiplatelet Regimes on Clot Microstructure in Patients Treated for ST Elevation Myocardial Infarction: Clot Microstructure can Evaluate Therapeutic Efficacy Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-30 Matthew J. Lawrence, Daniel R. Obaid, Ahmed Sabra, Janet Whitley, Rhianwen Quarry, Suresh Pillai, Alexander J. Chase, David Smith, Phylip R. Williams, Karl Hawkins, Roger H.K. Morris, Phillip A. Evans
BackgroundUnfavourable clot microstructure is associated with adverse outcomes in ST elevation myocardial infarction (STEMI). We investigated the effect of comorbidities and anti-platelet treatment...
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Long-Term Trends of Coagulation Parameters in People Living With HIV Treated With Combined Antiretroviral Therapy Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-27 Soerajja Bhoelan, Jaime Borjas Howard, Vladimir Tichelaar, Wouter Bierman, Karina Meijer
Trends of coagulation parameters during long-term treatment with combination antiretroviral therapy (cART) are unclear. We followed 40 male subjects living with human immunodeficiency virus (HIV). ...
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A Single-Center Bleeding Comparison of Warfarin Plus Aspirin or Clopidogrel Following Coronary Artery Bypass Grafting and Surgical Valve Replacement Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-28 Joseph J. Zieminski, Kristin C. Mara, Kyle S. Wamsley, John M. Stulak, Scott D. Nei
The optimal antithrombotic therapy following combined coronary artery bypass graft (CABG) and surgical valve replacement (SVR) surgery remains unclear. The aim of this single-center, retrospective ...
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Perioperative Outcomes of Patients with Bleeding Disorders Undergoing Major Surgery at an Academic Hemophilia Treatment Center Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-27 Ruben Rhoades, Zachary French, Amy Yang, Karen Walsh, Douglass A. Drelich, Steven E. McKenzie
Persons with bleeding disorders (PwBD) are at high risk for bleeding with invasive procedures. However, the risk of bleeding in PwBD undergoing major surgery and outcomes of patients managed periop...
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A Longitudinal Study of Thrombosis and Bleeding Outcomes With Thromboprophylaxis in Pregnant Women at Intermediate and High Risk of VTE Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-27 E. Schapkaitz, E. Libhaber, A. Gerber, H. Rhemtula, J. Zamparini, B.F Jacobson, H.R Büller
BackgroundThe efficacy and safety of thromboprophylaxis in pregnancy at intermediate to high risk of venous thrombo-embolism (VTE) is an area of ongoing research.AimThis study aimed to assess throm...
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Combination of D-dimer and Albumin in the Prediction of Deep Vein Thrombosis in Patients with Spontaneous Intracerebral Hemorrhage Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-22 Lingli Chen, Wanli Zhang, Chunfeng Liu
Background and PurposeDeep venous thrombosis (DVT) makes spontaneous intracerebral hemorrhage (ICH) treatment more challenging. We aimed to determine the predictive ability of D-dimer combination w...
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Glycemic Control and Plasma Levels of Pro-Inflammatory and Pro-Thrombotic Biomarkers in Diabetic Patients Presenting with Acute Pulmonary Embolism Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-20 Alexander O’Hara, Jacob Pozin, Amir Darki, Fakiha Siddiqui, Debra Hoppensteadt, Jeanine Walenga, Jawed Fareed, Bulent Kantarcioglu
Type I and type II diabetes are closely associated with a pro-inflammatory state and to a pro-thrombotic state. The role of glycemic control in pulmonary embolism (PE) is poorly understood and requ...
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Interrelationship Between Inflammatory Biomarkers and Collagen Remodeling Proteins in Atrial Fibrillation Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-20 Ameer Odeh, Gabriel D. Dungan, Debra Hoppensteadt, Fakiha Siddiqui, Bulent Kantarcioglu, Amir Darki, Jawed Fareed, Mushabbar A. Syed
IntroductionAtrial Fibrillation (AF) is the most prevalent cardiac arrhythmia worldwide. Inflammation and structural remodeling of the left atrium are thought to be involved in the pathogenesis of ...
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Risk Factors of Deep Vein Thrombosis in Adults with Acute Compartment Syndrome Following Lower Extremity Fractures Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-20 Shuo Yang, Tao Wang, Yubin Long, Junfei Guo, Zhiyong Hou
This study aimed to identify the risk factors of deep vein thrombosis (DVT) in adults with acute compartment syndrome (ACS) following lower extremity fractures. We collected data on adults with ACS...
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Fibrinolytic Status and Risk of Death After Acute Pulmonary Embolism Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-13 Yevgeniy Brailovsky, Vladimir Lakhter, Joshua Newman, Sorcha Allen, Ahmed Elkaryoni, Parth Desai, Dalila Masic, Carlos F. Bechara, Emily Bontekoe, Debra Hoppensteadt, John J. Lopez, Fakiha Siddiqui, Omer Iqbal, Jawed Fareed, Amir Darki
BackgroundAcute pulmonary embolism (PE) is a heterogeneous disease process with variable presentation and outcomes. The endogenous fibrinolytic system is a complex framework of regulatory pathways ...
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Potency Adjusted Blended Heparin of Bovine, Ovine, and Porcine Heparin Exhibit Comparable Biologic Effects to Referenced Single-Sourced Porcine Heparin Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-12 Guy Olson, Walter Jeske, Omer Iqbal, Emily Krupa, Amber Farooqui, Fakiha Siddiqui, Debra Hoppensteadt, Ahmed Kouta, Jawed Fareed
Introduction: Bovine and ovine mucosa represent alternate anticoagulants to porcine mucosa for production of unfractionated heparin (UFH). Standardized heparins from various sources can be blended ...
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Upregulation of Coagulation Factor VIII and Fibrinogen After Pulmonary Endarterectomy in Patients with Chronic Thromboembolic Pulmonary Hypertension Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-08 Lasse Myllylahti, Jussi Ropponen, Mikko Lax, Riitta Lassila, Antti I. Nykänen
ObjectivesChronic thromboembolic pulmonary hypertension (CTEPH) is associated with thrombotic states including elevated coagulation factor VIII (FVIII). Pulmonary endarterectomy (PEA) is the main t...
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Retrospective Analysis of Direct-Acting Oral Anticoagulants (DOACs) Initiation Timing and Outcomes After Thrombolysis in High- and Intermediate-Risk Pulmonary Embolism Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-08 Adam Wolfe, Angela Phillips, David M Tierney, Roman Melamed, Ghazi Qadri, Matthew Lillyblad, Claire Smith, Catherine St. Hill, Ashley E Stenzel, David Beddow, Justin Kirven, Rajesh Kethireddy, Love Patel
Direct-acting oral anticoagulants (DOACs) are prescribed in the treatment of venous thromboembolism, including pulmonary embolism (PE). Evidence is limited regarding the outcomes and optimal timing...
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The Detection of Hypercoagulability in Patients with Acute Cerebral Infarction Using a Clot Waveform Analysis Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-06 Toshitaka Kamon, Shotaro Horie, Tomoya Inaba, Nobuo Ito, Katsuya Shiraki, Yuhuko Ichikawa, Minoru Ezaki, Hideto Shimpo, Motomu Shimaoka, Akisato Nishigaki, Akihiro Shindo, Hideo Wada
A few studies concerning hypercoagulable states have sufficiently been reported in patients with acute cerebral infarction (ACI), as ACI is generally considered to be caused by platelet activation....
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Implementation of the Management of Anticoagulation in the Periprocedural Period App into an Electronic Health Record: A Cost-Effectiveness Analysis Clin. Appl. Thromb. Hemost. (IF 2.9) Pub Date : 2023-03-06 Jason J. Wang, Ioannis Koulas, Anne Myrka, Alex C. Spyropoulos
The Management of Anticoagulation in the Periprocedural Period (MAPPP) app is a free tool providing up-to-date guidelines on the periprocedural management of patients on long-term anticoagulants. A...